Cell and Gene Therapy Firms Gear up to Revolutionize Manufacturing – Labiotech.eu

With the rising demand for cell and gene therapies, the need for manufacturing innovation has never been higher. A surge of deals and expansions in the last year is fuelling the push to truly make these therapies widely available and affordable.

Cell and gene therapies offer huge potential to treat a wide range of diseases including cancer, neurological, and genetic diseases. They have even shown promise to treat the symptoms of Covid-19.

The amount of academic and early-stage biotech research in this area has skyrocketed over the last few years. According to the Alliance for Regenerative Medicine, there are currently 1,220 ongoing clinical trials in this space, 152 of which are at phase III. Despite the global pandemic, investment in this area is also at a record high around the world, with the equivalent of 15.7B invested in 2020, a figure double that of 2019.

But research alone cannot get these complex treatments to patients. The sharp discrepancy between the high number of products in early-stage development and the still very small number that have made it onto the market, as well as their cost, speaks to the impact and importance of cost-effective and scalable manufacturing, Ryan Cawood, CEO of Oxgene (previously Oxford Genetics), told me. Oxgene is a UK biotech aiming to improve manufacturing for cell and gene therapies.

To meet this challenge, cell and gene therapy producers are exploding into motion. With 2021 only just getting started, weve seen manufacturing deals between Vigeneron and Daiichi Sankyo, Sirion Biotech and Cellectis, and Cevec and Biogen. The giant Thermo Fisher Scientific absorbed the Belgian viral vector producer Henogen for 724M. And CDMO heavyweights like Cognate BioServices and Polyplus Transfection have announced expansions to their manufacturing capacity.

Thedifficulties with manufacturing the recently approved Covid-19 mRNA vaccines in high enough quantities has really highlighted the importance of having a solid manufacturing strategy in place. This lesson applies equally to companies trying to take cell and gene therapies to market.

Stuck in the first generation

Despite the huge increase in development of cell and gene therapies over the past couple of years, manufacturing technology for these therapies is largely still at the first-generation stage. This can make scaling up a challenge.

Often cell and gene therapy manufacturing processes are highly manual stemming from the early academic or process development stage and, without adequate technology solutions available currently, these processes often remain this way through clinical trials and then into commercial manufacturing, said Jason Foster, CEO of Ori Biotech, a London- and New Jersey-based company focusing on cell and gene therapy manufacturing.

These first-generation processes cause manufacturing to be expensive, highly variable and low-throughput, which reduces the ability of patients to access these potentially life-saving therapies.

Another problem common to all bio-based therapeutics is that any product sourced from a live cell or a component of one is subject to a lot more variation than a simpler pharmaceutical product.

Most gene therapies are built on viruses found in nature. They have not evolved for very high productivity in a large-scale, animal component-free bioreactor, said Cawood.

The more complicated the biologic becomes, the more parts of it require optimization, and the more analytics you require.

According to Kevin Alessandri, the cofounder and CEO/CTO of the French company TreeFrog Therapeutics, there is also a lot of waste in cell therapy manufacturing.

Yields are impaired by high cell death at every passage, and genetic alterations inevitably arise, said Alessandri. When it comes to producing commercial batches to treat thousands of patients, scaling out 2D cell culture processes is far too expensive and poses batch-to-batch reproducibility issues.

While many in the industry are now turning to bioreactors to produce cells on a bigger scale, this is also not without problems. Impeller-induced shear stress is damaging the cells, thus negatively impacting cell viability and triggering undesired genetic mutations, explained Alessandri.

Taking manufacturing up a gear

What are companies in this space doing to make scaling up cell and gene therapies easier, quicker, and cheaper?

Ori Biotech raised24.8M in Series A funding in October last year to develop an automated and robotic manufacturing system to minimize the number of manual steps needed to produce a given cell or gene therapy. This speeds up the process as well as making it more accurate. Another advantage of the technology is that it can tailor the production capacity according to demand.

This is impossible to do in most current processes, which involve manual tube welding and transfers from flask to bag to bigger bag to bioreactor, said Foster, adding that this increases cost and variability while constraining throughput. Oris technology, in contrast, could take years off the production timeline and cut costs by as much as 80%.

London-based Synthace is one of several companies trying to improve advanced therapeutic manufacturing by developing software and computer systems to optimize the process, rather than industrial machinery.

Peter Crane, Corporate Strategy Manager for the company, said that in-depth data analysis and planning before starting the manufacturing process can make a big difference to outcomes, and that connected software can help make this task easier.

The best way to remove some of the risk associated with biomanufacturing of these products is to solve as many problems as possible before manufacturing.

In addition to making the process quicker, cheaper, and more accurate, computing tools can also help with quality control and tracking. In cell therapy manufacturing, especially autologous products, line of sight around electronic batch records, as well as the vein-to-vein supply chain, is incredibly important, emphasized Crane.

Another company specifically focusing on logistics and quality control is the Cardiff- and San Francisco-based TrakCel, which nailed deals with Ori Biotech in February and the UKs National Health Service in November.

The company TreeFrog Therapeutics works with cell encapsulation technology to improve quality and reduce waste, albeit from a more mechanical viewpoint. The company launched an industrial demonstration plant in June last year, followed by two co-development deals with undisclosed big pharma partners.

Encapsulated stem cells spontaneously self-organize in an in vivo-like 3D conformation promoting fast and homogeneous growth, as well as genomic stability, said Alessandri. The resulting 3D stem cell colony can then be differentiated in the capsule into functional microtissues ready for transplantation.

With our technology, which is based on high-throughput microfluidics capable of generating over 1,000 capsules per second, it becomes possible to expand and differentiate stem cells at a large scale, in industrial bioreactors, with best-in-class cell quality and reduced operating costs.

Oxgene has a focus on scaling up production for manufacturers. In September, the company launched a technology to scale up manufacturing of viral vector production with less contamination and a 40-fold improvement in yield compared to current methods. Oxgenes expertise with viral vectors also prompted a collaboration deal in April with the CDMO Fujifilm Diosynth Biotechnologies.

Innovation in new manufacturing technologies just hasnt kept pace with the level of discovery around genetic disease and potential avenues open to treat them, or even development of the viral vectors themselves, said Cawood. This is definitely changing though.

Enter the second generation of manufacturing

Cell and gene therapy manufacturing is definitely hot right now, boosted by increased needs from biotech and pharma companies developing Covid-19 vaccines and therapies, and by notable increases in investment.

Huge advances in gene and cell therapies over the last few years, such as the approval of the eye gene therapy Luxturna and the first CAR T-cell therapies, mean the demand for new manufacturing technologies has also increased exponentially.

A lot of very promising programs are now in the pipeline, and patients are waiting for their approval, said Alessandri. Industry urgently needs robust manufacturing technology, capable of serving millions of patients.

European biotechs are busy developing second-generation technologies to allow easier and cheaper scale up, producing higher quality products with less waste. They could start to phase out first-generation methods very soon.

The realm of cell manufacturing in industrial and food biotech is also likely to see big breakthroughs in the coming years. Earlier this month, for instance, the nutrition and health giant Royal DSM set up a lab in the Netherlands dedicated to applying artificial intelligence (AI) to the challenge of growing microbial strains at a commercial scale.

Rapid improvements in advanced computing options such as AI and machine learning technology, as well as robotics, are already having an effect on the industry, but this will only get bigger as time goes on.

Cover image from Elena Resko. Body text image from Shutterstock

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Cell and Gene Therapy Firms Gear up to Revolutionize Manufacturing - Labiotech.eu

Stem Cell Recruitment Therapy Registration Awarded by U.S. Patent & Trademark Office for Russell Health – MDJOnline.com

WILLOWBROOK, Ill., Jan. 26, 2021 /PRNewswire/ --Based in Willowbrook, Illinois, Russell Health, a national marketer and distributor of specialty medical products and services, has recently been issued company trademark registrations from the United States Patent and Trademark Office.

Russell Health, Inc., a leading regenerative medicine company, announced today the United States Patent and Trademark Officehas issued registrations for the company's trademarks - Stem Cell Recruitment Therapy (Reg. No. 6,109,514) and Stem Cell Recruitment Facial (Reg. No. 6,218,705), signifying that the company has met the stringent United States standards for exclusively applying its trademarks to the company's products.

Media Approved Quote:"Being a leader in regenerative medicine, we have made it a priority to invest in our Intellectual Property and trademarks across our company. We are excited at the Patent Office's decision to award us with two highly valuable registered trademarks. We are planning to expand our Stem Cell Recruitment Therapy and Stem Cell Recruitment Facial brands nationwide." (Ryan Salvino, CEO)

About Russell Health: Russell Health is a national marketer and distributor of specialty medical products and services. Together with our partners and suppliers, we work to provide innovative life-changing and sustaining products and therapies to patients and healthcare providers around the world. Russell Health and its partners have distributed regenerative therapy products nationwide and achieved profound clinical outcomes in multiple therapeutic areas including cosmetics, wound care, pain management, podiatry, orthopedics, ocular and gynecology. Our knowledge of national markets combined with our strong industry relationships, our location and our relevant industry experience make us highly effective at building sales channels that deliver great results. We pride ourselves in having a high level of integrity and being a trusted partner and advisor to our practitioners, manufacturers and patients. These trademarks exclusively distinguish our fine products and services from those of other products in the industry.Customers can always count on Russell Health for the best quality specialty medical and regenerative products solutions in a variety of specialty areas.

Disclaimer

Stem Cell Recruitment (SCR), Stem Cell Recruitment Therapy (SCRT), Stem Cell Recruitment Facial ,DermaFlo, OrthoFactor and Vivaderm are trademarks of Russell Health, Inc. The treatments described on thismarketing are not considered to be standard of care for any condition or disease. SCR, SCRT, SCR Facial andVivaderm attempt to utilize acellular, minimally manipulated tissue allografts and are comprised of tissue allograftcomponents intended for homologous use to supplement tissue. These statements have not been evaluated by the FDA.This product is not intended to diagnose, treat, cure or prevent any disease. Results may vary.

Visit Russell Health online to learn more about Stem Cell Recruitment Therapy. For media inquiries or to contact the Russell Health team directly. Please visit http://www.russellhealth.comor email marketing@russellhealth.com.

Contact:

Veronica BennettPhone: 312-919-1896Email: marketing@russellhealth.com

Mailing Address: 621 Plainfield Rd., Willowbrook, IL 60527

Online: http://www.russellhealth.com

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Stem Cell Recruitment Therapy Registration Awarded by U.S. Patent & Trademark Office for Russell Health - MDJOnline.com

Animal Stem Cell Therapy Consumption Market Report By Application, Type, Top Companies, Growth, Regional Outlook, and Forecast to 2027 Murphy’s…

New Jersey, United States,- Animal Stem Cell Therapy Consumption Market Report, published by Market Research Intellect, provides an industry assessment of the Animal Stem Cell Therapy Consumption market covering the most important factors driving the growth of the Animal Stem Cell Therapy Consumption industry. Animal Stem Cell Therapy Consumptions latest market research report contains an extensive analysis of micro and macroeconomic indicators affecting the development of the global market in the forecast period 2020-2027.

The current trends of the Animal Stem Cell Therapy Consumption market, combined with broad growth opportunities, key drivers, constraints, challenges and other important aspects, are detailed in the Animal Stem Cell Therapy Consumption market report. Additionally, the report makes many development prospects for key players involved in the Animal Stem Cell Therapy Consumption industry taking into account various market dynamics.

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Animal Stem Cell Therapy Consumption Market Report By Application, Type, Top Companies, Growth, Regional Outlook, and Forecast to 2027 Murphy's...

Vertex Announces FDA Clearance of Investigational New Drug (IND) Application for VX-880, a Novel Cell Therapy for the Treatment of Type 1 Diabetes…

BOSTON--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that the U.S. Food and Drug Administration (FDA) has cleared the IND, enabling the company to proceed with initiating a clinical trial for VX-880, an investigational stem cell-derived, fully differentiated pancreatic islet cell therapy to treat T1D. Vertex plans to initiate a Phase 1/2 clinical trial in the first half of 2021 in patients who have T1D with impaired hypoglycemic awareness and severe hypoglycemia.

As we celebrate the 100th anniversary of the discovery of insulin this year, we are excited to bring a first-in-class cell therapy to the clinic with the potential to meaningfully impact people living with T1D, said Bastiano Sanna, Ph.D., Executive Vice President and Chief of Cell and Genetic Therapies at Vertex. We look forward to getting our clinical program underway and testing our unique approach of replacing pancreatic islet cells, which are destroyed in people with type 1 diabetes, with our stem cell-derived fully differentiated insulin-producing pancreatic islet cells.

About VX-880VX-880, formerly known as STx-02, is an investigational allogeneic human stem cell-derived islet cell therapy that is being evaluated for patients who have T1D with impaired hypoglycemic awareness and severe hypoglycemia. VX-880 has the potential to restore the bodys ability to regulate glucose levels by restoring pancreatic islet cell function, including insulin production.

The VX-880 clinical trial will involve an infusion of fully differentiated, functional islet cells, as well as the chronic administration of concomitant immunosuppressive therapy, to protect the islet cells from immune rejection.

About the Phase 1/2 Clinical TrialThe clinical trial is a Phase 1/2, single-arm, open-label study in subjects who have T1D with impaired hypoglycemic awareness and severe hypoglycemia. This will be a sequential, multi-part clinical trial to evaluate the safety and efficacy of different doses of VX-880. Approximately 17 patients will be enrolled in the clinical trial.

About Type 1 DiabetesT1D results from the autoimmune destruction of insulin-producing islet cells in the pancreas, leading to loss of insulin production and impairment of blood glucose control. The absence of insulin leads to abnormalities in how the body processes nutrients, leading to high blood glucose levels. High blood glucose can lead to diabetic ketoacidosis and over time, to complications such as kidney disease/failure, eye disease (including vision loss), heart disease, stroke, nerve damage and even death. Due to the limitations and complexities of insulin delivery systems, it can be difficult to achieve and maintain balance in glucose control in patients with T1D. Hypoglycemia remains a critical limiting factor in glycemic management, and severe hypoglycemia can cause loss of consciousness, coma, seizures, injury, and can be fatal.

There are currently limited treatment options beyond insulin for the management of T1D.

About VertexVertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has multiple approved medicines that treat the underlying cause of cystic fibrosis (CF) a rare, life-threatening genetic disease and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational small molecule medicines in other serious diseases where it has deep insight into causal human biology, including pain, alpha-1 antitrypsin deficiency and APOL1-mediated kidney diseases. In addition, Vertex has a rapidly expanding pipeline of cell and genetic therapies for diseases such as sickle cell disease, beta thalassemia, Duchenne muscular dystrophy and type 1 diabetes mellitus.

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia and Latin America. Vertex is consistently recognized as one of the industry's top places to work, including 11 consecutive years on Science magazine's Top Employers list and a best place to work for LGBTQ equality by the Human Rights Campaign. For company updates and to learn more about Vertex's history of innovation, visit http://www.vrtx.com or follow us on Facebook, Twitter, LinkedIn, YouTube and Instagram.

Special Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, statements made by Bastiano Sanna, Ph.D., in this press release, statements regarding the development, plans and expectations for our T1D pipeline program, including our plans to initiate a Phase 1/2 clinical trial in people with T1D and expected timeline of our clinical trials, statements regarding patient enrollment and dosing, statements regarding potential clinical trial results and anticipated benefits of VX-880, and our plans to provide further updates on our T1D pipeline program. While Vertex believes the forward-looking statements contained in this press release are accurate, these forward-looking statements represent the company's beliefs only as of the date of this press release and there are a number of risks and uncertainties that could cause actual events or results to differ materially from those expressed or implied by such forward-looking statements. Those risks and uncertainties include, among other things, that the FDA may not approve our IND, that data from a limited number of patients may not be indicative of final clinical trial results, that data from the company's development programs may not support registration or further development due to safety, efficacy or other reasons, that the COVID-19 pandemic may impact the status or progress of our clinical trials, and other risks listed under the heading Risk Factors in Vertex's most recent annual report and subsequent quarterly reports filed with the Securities and Exchange Commission at http://www.sec.gov and available through the company's website at http://www.vrtx.com. You should not place undue reliance on these statements. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available.

(VRTX-GEN)

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Vertex Announces FDA Clearance of Investigational New Drug (IND) Application for VX-880, a Novel Cell Therapy for the Treatment of Type 1 Diabetes...

Dancing on Ice’s Colin Jackson to get stem cell op as he’s got ‘knees of 85-year-old’ – Irish Mirror

At the age of 53, Dancing On Ice favourite Colin Jackson looks every inch the super-fit Olympian.

But the sporting icons winning smile as he skates with partner Klabera Komini hides a world of pain.

Because today, 110m hurdles hero Colin tells how track stardom has left him with the knees of an octogenarian.

The former world record holder is in constant agony, struggles to get out of his car and fears he could even end up in a wheelchair.

But he is now facing his biggest hurdle of all stem cell therapy to repair his damaged knees.

Colin says the treatment, which will begin next week, is the last roll of the dice to avoid joint replacement surgery.

Im in constant pain but you learn to live it with it, says the 1988 Olympic silver medallist and former World Champion hurdler.

Ive got the body of a man in his mid-30s but the knees of a man in his mid-80s. Ive had seven operations on my knees already four on the right knee and three on the left knee.

"I just cant face any more.

My knees lock up after long car journeys, and getting in and out of the bath is awkward.

It takes me ages to get going in the morning.

Colins glittering career left him with extensive damage to his kneecaps, cartilage, ligaments and tendons and he also has a degenerative condition that can make it difficult to get out of bed, let alone skate.

He needs to do a string of warm-up exercises every morning and has to take paracetamol and ibuprofen before every rink training session.

But Colin, a runner-up on Strictly Come Dancing in 2005, reckons his mental toughness is getting him through his sessions on the ice.

His family tried to talk him out of appearing on the hit ITV show, fearing he could suffer life-changing injuries if he falls.

But the will to win that once shot Colin to athletics stardom shone through.

I dont believe my knees will hamper my progress on the show, he says. That may sound contradictory because I am in pain, but Im in pain every day anyway, whether Im on the show or not.

My family is worried and just keep telling me to be careful but Im just not built that way. I love the challenge.

Right now, Ill compete and worry about things afterwards.

Colin is pinning all his hopes on starting the stem cell therapy and says hes praying for a miracle.

Its definitely the last roll of the dice to avoid knee replacement surgery somewhere down the line, he says.

Otherwise I will have to have more surgery at some stage. There is no doubt about that.

Im praying for a miracle because I really dont want knee replacements and I dont want to be in a wheelchair.

I want to be able to walk down the street when Im older. As part of his treatment, the BBC athletics commentator will have one million stem cells injected into each knee and more cells delivered afterwards via an IV drip.

The first session to prepare his body for the jabs will take place at Harley Street Stem Cell Clinic in London next week. Overall, it will cost him 25,000.

Colin is being treated by Dr Aamer Khan, who has specialised in the remarkable therapy since 2009.

Dr Khan said: Human stem cells are able to develop into different cell types that can be used to replace damaged tissue all over the body. They can drastically improve an individuals overall quality of life by reducing pain.

Colins condition will get worse if untreated and joint replacement is a real possibility if the therapy doesnt work. If it does, however, Colin could feel improvements in just four weeks and the full benefit after 12.

In the meantime, he plans to keep going for as long as he possibly can on Dancing On Ice a show notorious for falls and injuries.

So far this series, two professional skaters have been hospitalised because of training injuries and celeb contestant Denise van Outen dislocated her shoulder.

But Colin knows hes no longer the young athlete who thought nothing of pushing himself to the limit during his career.

When you are young, you dont worry about it, he says.

But when you get older, you realise the grief you have caused yourself. On a good day, the pain level is three out of 10 but on a bad day its a 10.

Being down on my knees is painful and I have to be careful with twisting and turning. But I still work out, I still go to the gym and do yoga and Pilates because I dont want to give in to it.

Before I train I will take ibuprofen so I dont exacerbate the problem.

But Im worried about walking on the pavement when its icy out, so I must be completely mad to be doing Dancing On Ice!

Colin says he was aware of what was coming during his career. I knew my knees were going to be a problem but I hadnt started to feel it until I got into my 50s, he says.

I still want an outdoor life. I still want to ski and go snowboarding. Im terrified my lifestyle will be badly affected but also that the everyday things might become difficult.

Colin says that these days, he cant even contemplate the sport that made him famous.

I couldnt clear a hurdle. Forget it. My knees wont let me, he says.

Ive attempted some small hurdles but the next day, my knees were really killing me. I just cant do those things any more.

When Dr Khan told me he may be able to help just before Christmas, I said, Lets give it a go. Ive got nothing to lose.

But this is a degenerative problem and there is huge potential I could end up in a wheelchair without a knee replacement or if the stem cell therapy doesnt work.

Colin realises people will probably think he is crazy for doing Dancing On Ice when the consequences of a fall could be so serious for him.

But he says: I feel that the other parts of my body are strong.

Being an athlete, Ive had so much treatment, injections and surgeries and still competed and had to perform so I am in the same mindset for Dancing On Ice. Its not new to me.

Every day as an athlete, I would perform with injuries and then hobble into bed but then go out the next day and do it all again.

It is something built into you when you have competed at the highest level, but Im not a fool.

Im not going to be like I was at 21 after the treatment, but if I can get 10% better, thats a huge amount of pain relief.

If the therapy doesnt work and Dr Khan says, Stop going to the gym, stop skiing and snowboarding because they are going to wear out your knees, then that would be difficult.

Its on my mind because being sedentary is not a good thing for me.

Its going to be a bitter pill if it comes to that but Im just praying the stem cells work their miracle.

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Dancing on Ice's Colin Jackson to get stem cell op as he's got 'knees of 85-year-old' - Irish Mirror

Advanced Pancreatic Cancer Pipeline Therapeutics and Analysis, 2021 – GlobeNewswire

Las Vegas, USA, Feb. 01, 2021 (GLOBE NEWSWIRE) -- Advanced Pancreatic Cancer Pipeline Therapeutics and Analysis, 2021

ERYtech Pharma, GlaxoSmithKline, Galera Therapeutics, Propanc and several other key companies are set to transform the Advanced Pancreatic Cancer Pipeline landscape in the coming years.

DelveInsights, Advanced Pancreatic Cancer Pipeline Insights, 2021 report provides comprehensive insights about 100+ companies and 100+ pipeline drugs in the Advanced Pancreatic Cancer pipeline landscape. It comprises Advanced Pancreatic Cancer pipeline drug profiles, including clinical and non-clinical stage products. It also includes the Advanced Pancreatic Cancer therapeutics assessment by product type, stage, route of administration, and molecule type, and further highlights the inactive Advanced Pancreatic Cancer pipeline products.

Key Advanced Pancreatic Cancer Pipeline Report Highlights

Request for free sample pages @ Advanced Pancreatic Cancer Therapeutics

Advanced Pancreatic Cancer means cancer has spread from where it started or has come back sometime after treatment (recurrence). Advanced Pancreatic Cancer Treatment is usually chemotherapy. Chemotherapy travels via the bloodstream to reach cancer cells, which are in many places throughout the body. This treatment may reduce the tumors or impede their growth and may benefit patients to live longer.

Advanced Pancreatic Cancer Pipeline Therapeutics

The lead product candidate, Eryaspase consists of L-asparaginase encapsulated inside donor-derived red blood cells, targets the cancer cells altered asparagine and glutamine metabolism. Eryaspase is in phase III clinical development for the second-line pancreatic cancer treatment and in phase II for first-line triple-negative breast cancer treatment. Leveraging its proprietary ERYCAPS platform that utilises a novel technology to encapsulate drug substances inside red blood cells, ERYtech develops a pipeline of product candidates for patients with high unmet medical needs.

For further product profiles, request @ Advanced Pancreatic Cancer Pipeline Insight Report

Scope of Advanced Pancreatic Cancer Pipeline Drug Insight

Key Questions regarding Current Advanced Pancreatic Cancer Treatment Landscape and Emerging Therapies Answered in the Pipeline Report

Table of Contents

Get customised pipeline report @ Advanced Pancreatic Cancer Pipeline Report

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Advanced Pancreatic Cancer Pipeline Therapeutics and Analysis, 2021 - GlobeNewswire

How Do We Regain Trust in Institutions? – The New York Times

MISTRUSTWhy Losing Faith in Institutions Provides the Tools to Transform ThemBy Ethan Zuckerman

In his new book, Mistrust, Ethan Zuckerman takes us on a kaleidoscopic tour of everyone from Gandhi to Bitcoin enthusiasts, Brexit voters to Black Lives Matter activists people and groups whom he calls insurrectionists because they are trying to overthrow or work around what has been a worldwide decline in social trust. Fighting this erosion from another direction are the institutionalists, those who seek to bolster trust and prevent any further crumbling.

Zuckerman, the former director of the M.I.T. Center for Civic Media, writes with the tone of a sobered-up insurrectionist whos come to see in Donald Trump, QAnon and antimask activists the dark side of a society in which all trust is lost and anything goes. Rather than liberation, Zuckerman correctly explains, this systematic distrust has proved to be a blessing for authoritarians around the world who have only further undermined traditional arbiters of truth (say, journalists) in order to open the way to their own propaganda. He offers the particularly absurdist example that in Vladimir Putins Russia, so all-encompassing is the leaders control that many Russians see the mere fact that a dissident leader like Alexey Navalny hasnt been murdered (yet) as evidence that he doesnt represent a real opposition force.

Its clear Zuckerman hasnt abandoned his insurrectionist sympathies for those trying to work outside a system they see as irreparably broken. He writes sympathetically about plainly loopy ideas like seasteading (the libertarian fantasy of building floating communities outside the reach of established states) and using the same blockchain technology that powers cryptocurrency to establish new virtual nation-states.

But he seems to find most promising those activists with more conventionally progressive politics who embrace new tactics. He offers the fascinating story of the Association for the Empowerment of Workers and Peasants in India, along with the more familiar tales of Bryan Stevenson and the success of digital activists in reshaping coverage of law enforcement.

One of his big examples is the Black Lives Matter movement. Citing research from his former lab at M.I.T., he notes that after Michael Browns death and the protests in Ferguson, police killings of people of color were 11 times more likely to receive media coverage than deaths that preceded Browns. Media stories also became far more likely to cover a story not as an isolated incident but as part of a pattern of police violence against people of color.

Zuckermans heroes have what he calls strong internal efficacy (they believe they can do things) but low external efficacy (they think political leaders dont care about them). So they operate outside the system, pressuring retailers to change their approach to selling firearms, decentralizing institutions or shifting media coverage.

#MeToo is a different kind of movement, he writes. Sexual assault and harassment have been illegal for years, so its main demands are for changes not in law but in norms.

This feels like an unsatisfactory effort to rebrand failure as success. The social media phenomenon revealed that conduct short of assault but still deeply troubling to its victims is fairly widespread in American life. And nothing fundamentally changed no alteration to legal liability rules for employers, managers or bystanders, for example to redress that situation. I hope that norms have changed, but theres no clear evidence that they really have. Much-deserved Pulitzer Prizes were won, but crack investigative journalists exposing predators one by one is a not a viable fix.

This is where Zuckerman himself lands when considering the coronavirus pandemic and where he illustrates best the limits of the insurrectionists: Actual functioning institutions became indispensable, and couldnt simply be worked around with internal efficacy and digital savvy.

Recounting a conversation with the activist Eli Pariser, Zuckerman proclaims himself a resurrectionist who believes that we need institutions that deserve our passionate support and defense, and if the institutions we rely on now do not clear that bar, we need to demand new ones that take their place. That seems correct and sensible, though it perhaps raises the question of what the point was in introducing the dichotomy in the first place.

Zuckerman concludes his book by saying that we are likely to find that institutions fail when we no longer recognize ourselves as a single nation, when we no longer feel responsibility for or obligation to our fellow citizens.

Out of context, one could imagine that flowing from the pen of Stephen Miller as part of a denunciation of globalist preoccupation with asylum seekers and the perfidious work of the 1619 Project in tearing down our common culture. In the course of a book that praises the protests that halted Trumps zero tolerance immigration initiative and casually tosses off an endorsement of Ta-Nehisi Coatess case for reparations, Im quite sure thats not what he means. But in many respects the divide between a call for unity that can be read as nationalistic and one that can be understood as cosmopolitan is the real split in the world today.

Another way of thinking about institutional trust is precisely in terms of that divide.

Major institutions have long been led primarily by the members of an educated elite. But its only over the past generation or so that college graduates with cosmopolitan attitudes have become a large enough share of the population that educated peoples sensibilities could be a force in mass politics. Consequently, today institutional leaders face meaningful pressure often from some of the young, college-educated activists whom Zuckerman valorizes like David Hogg, fighting for gun control, and Alicia Garza of Black Lives Matter to use their power to reflect and act on those views. But when they yield, they face fierce backlash from a populist right rooted in the cultural sensibilities of older, whiter, generally less-educated people.

Meanwhile, there are those who feel caught between these worldviews: the working-class people of color who largely eschew left-wing radical chic and feel the pull of things like patriotism and traditional gender norms without wanting to hop on a right-wing bandwagon inflected with racism and indifference to the material needs of the lower class. These are precisely the people with the least direct access to media attention or the political process. They are the ones, more than the insurrectionists of left or right, that institutional leaders need to find a way to better serve if they want to preserve their power and restore their legitimacy.

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How Do We Regain Trust in Institutions? - The New York Times

Swedish film festival to screen on remote island for audience of one – Reuters

STOCKHOLM (Reuters) - Scandinavias biggest film festival is going ahead this year despite the coronavirus pandemic, but will be hosted on an isolated island and admit only one attendee - a healthcare worker, selected from 12,000 applicants.

Swedish nurse and film fan Lisa Enroth was chosen to be the 2021 Gothenburg Film Festivals castaway who will spend a week on the remote island of Pater Noster watching film after film.

In healthcare I seem to have spent ages listening, testing and consoling. I feel like Im drained of energy, Enroth said.

Pater Noster, on the boundary of a dense archipelago offSwedens west coat, is known for its lighthouse.

The wind, the sea, the possibility of being part of a totally different kind of reality for a week all this is really attractive, said Enroth, who will keep a daily video diary that will appear on the festivals website.

The festivals CEO Mirja Wester said: It feels particularly right to be able to give this unique experience to one of the many heroes of the healthcare system who are all working so hard against COVID-19.

Reporting by Colm Fulton; Editing by Raissa Kasolowsky

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Swedish film festival to screen on remote island for audience of one - Reuters

Tropical Snowstorm Drops 12"+ on Hawaii Island – Weatherboy

A snowboarder takes a break and soaks in the view of a snowy Hawaii atop Mauna Kea. Maui appears in the distance with the clouds. Image: Weatherboy

Not to be outdone by the incredible atmospheric river event that dumped more than 7 feet of snow in the Sierra Nevada earlier this week or the potential of blizzard-like conditions in the Mid Atlantic beginning this weekend, Hawaii got in on the wintertime weather action with its own snowstorm this week.While most people dont associate the tropical paradise Hawaii is known for with snow, theyre surprised to learn that it does snow in the winter due to the elevation of these volcanic peaks. Mauna Kea is the highest of the bunch at 13,803 feet. Mauis Haleakala is much lower at 10,023 feet. Because of that difference, Hawaii Island will see snow more frequently than the lower Maui Island. Just one storm last January dropped 2-3 feet of snow on Hawaii Island and created snow drifts that were far deeper.

On Sunday, the National Weather Service in Honolulu on the island of Oahu, which is responsible for issuing forecasts and advisories for the entire Aloha State, issued a Winter Storm Watch for Hawaii Islands Mauna Kea and Mauna Loa, the two highest volcanoes on the Big Island. Eventually, winter storm warning conditions appeared by Monday night, dumping more than a foot of snow some locals refer to as pineapple powder. Strong, gusty winds of more than 30 mph also whipped up the snow, creating white-out conditions in the areas being impacted by the heavy snow.

While heavy snow fell on the freezing cold higher elevations of Hawaii, soaking rains flooded portions of Hawaii, especially the eastern side of the island where bands of heavy rain marched through off the tropical Pacific. Glenwood recorded 7.82 within 24 hours while Mountain View saw 7.33; 7 fell in Kapapala Ranch while 6.99 of rain was recorded at the USGS gauge at Saddle Quarry.

While crews cleared roads of flood related debris on Tuesday, a snow removal crew got busy on Mauna Kea. While the site is visited by tourists, Hawaiian cultural practitioners, and of course, winter sports enthusiasts in the winter, the area just below the summit of Mauna Kea is home to some of the most powerful and advanced telescopes on Earth. To make sure technicians and related astronomers have access to the facilities on the mountain, crews work diligently to plow and blow the snow off the roads.

The Hawaiian landscape, dotted with telescopes of different types and sizes, saw a fresh 1-2 feet of snow this week. With the access road now plowed out, winter sports fans had a full day to play in what locals refer to as pineapple powder. #HIwx pic.twitter.com/AAVirCfcIw

the Weatherboy (@theWeatherboy) January 29, 2021

By Wednesday morning, most of the roads to and around the summit were clear of snow, giving members of the astronomy community the chance to drive up nearly 14,000 feet to work in the sky. However, freezing fog and light snow shower activity returned later in the day, forcing rangers that patrol the mountain to close down the access road to visitors once again.

On Thursday, with clear blue skies over Hawaiis Big Island and clear, dry roads available to the summit, the mountain was once again open to visitors.

While many visitors simply looked around in awe of the wintry beauty and were busy taking pictures and shooting video, sports enthusiasts of different skill sets took to the slopes to enjoy the snow.

Near a small plowed-out parking area close to the summit, families brought their children to sled around a 20 gentle slope. Beginner skiers and snowboarders also used this bunny hill to get acclimated to sliding around in the snow and the altitude. At altitudes greater than 9,000 feet, altitude sickness could become problematic to even the most physically fit people.

About two dozen snowboarders and a few skiers took to the slopes, gliding down the snow-covered volcanic terrain around the telescopes at Mauna Keas peak on Thursday afternoon. Captain Cook, Hawaiis Tai Johnson tells us hell try to come to the peak and snowboard for the 1 or 2 big winter snowstorms that hit the area. Also an avid surfer of the Kona side surf spots, Johnson says its also possible to surf and snowboard in the same day. Its a lot to go from the beach all the way to almost 14,000 feet, which will do a number on you. He adds, But you can totally go surfing and come back here when its slushier in the evening.

There is no infrastructure to support winter sports: no restrooms, no lodge, no equipment rentals, and no lifts. Locals take pick-up trucks to the summit and give each other rides back up the snowboardable slopes.

We call it the local lift; its a free lift; its hitch-hiking with your thumb, Johnson said. And its friendly enough where everyone will give you a ride. He already enjoyed 20 rides down and up the mountain and says he can go down and up upwards of 50 times a day as long as his knees hold up.

Beyond shuttling snowboarders and skiers around the summit slopes, the pick-up trucks also come in handy to haul snow to lower elevations. Because of the high altitude, not everyone can handle the thin air where the snow falls. And with typical Hawaiian outfits consisting of slippers and shorts, many dont have any winter attire appropriate for the summit where temperatures may only top out in the 20s on snow-covered days. Because of this, many will load up their trucks with snow and haul it down to waiting friends and family in warmer locations on the island. While the temperatures was near 30 during our visit at the summit, temperatures were in the low 80s on Hawaiis sunny beaches.

In this weeks storm, both Mauna Kea and Mauna Loa were covered in snow. While the roads at the summit are improved to normal highway standards on Mauna Kea to deal with the astronomy related traffic there, the same isnt true for Mauna Loa. Mauna Loa, known as the worlds largest active volcano, is located across from Mauna Kea on Hawaiis Big Island. While its larger in volume than Mauna Kea, its a tad bit shorter, standing up at 13,678 feet compared to Mauna Keas 13,803. Because Mauna Loa is an active volcano and Mauna Kea isnt, there isnt much in the way of buildings or telescopes on it. While there are science stations and the HI-SEAS Lunar / Mars simulating lab are on Mauna Loa, a single narrow road rides up the slope and it stops short of the summit. With poor access to the snow there, it doesnt have the same draw as Mauna Kea does.

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Tropical Snowstorm Drops 12"+ on Hawaii Island - Weatherboy

London’s Retired Tube Trains Live on an Island – Atlas Obscura

Though it lies just a few miles off Englands southern coast, the curious, diamond-shaped Isle of Wight seems to exist in another era entirely. Once a beloved vacation destination for Victorian visitors, the island still reachable only by boat from the mainlandremains a British family holiday favorite that capitalizes on the kitschy seaside charm of yesteryear.

But the end of an era on the Isle of Wight is approaching. The islands train line, whose rolling stock has consisted exclusively of former London Underground carriages from the 1930s, is undergoing its biggest transformation in a generation.

Taken out of service in London in 1988, these Tube cars were moved to the Isle of Wights Island Line to see out their final days, which made them Britains oldest passenger trains in regular operation. But after 82 years of service, the time for retirement has come. In true Isle of Wight style, the decade dial is stuck somewhere in the past. From April 2021, the Island Lines vintage 1930s fleet will be replaced with new trainsformer Tube carriages from the 1980s.

The Island Line is not a museum and yet was operated by trains that are several decades older than can be found anywhere else on the network, and older even than much of the stock on many heritage railways, says Richard Long, author of Ryde Rail: A History of Tube Trains on the Isle of Wight.

The use of London Underground trains on the Isle of Wight can be traced back to a single tunnel. The island was one of the last places in the country to operate steam trains, which ran until 1967. As part of the electrification overhaul, the trackbed in a tunnel in Ryde, at the lines northern end, was raised to prevent flooding. This seemingly minor change decreased the clearance of the tunnel by 10 inches, meaning British Rails standard-size trains would no longer fit through. Seeking smaller alternatives, the government found the perfect option in a place where space is at a premium: the London Underground. The 1938 trainsClass 483 Electric Multiple Units, to give them their proper post-Underground namewere the second set of former Tube cars introduced to the Isle of Wight; the first Tube trains used on the Island from 1967 to 1992 were called Standard Stock, built in the 1920s.

With bright bauxite-red livery, metal- and teak-trimmed interiors and manual tip-out windows, the 1938 carriages were classic Art Deco. But soon style would be swapped for stamina.

The 38 Stock is the last train that you might describe as pretty inside, says Chris Nix, Assistant Director for Collections and Engagement at the London Transport Museum. Im going to get hate mail for saying that. After this generation of Tube trains, he says, a lot of the fixtures and fittings become more functional and are designed to stand up to abuse rather than being attractive.

Before arriving on the Isle of Wight, the Class 483s were refurbished and stripped of some of their original ornate features to make them more durable. But if you missed the chance to ride in one of the 1930s carriages on the Isle of Wight, the London Transport Museum is home to the best remaining example, acquired with the original Art Deco fixtures in situ, including waxy wooden floors, brooding forest-green interiors, ventilation grilles with swirling loops around a London Underground bullseye roundel, and shovel glass lamps, so named for the shape of the light cover. The Museum also has a four-car set at its depot in Acton, west London, which occasionally runs on heritage outings.

Some of the 38 Stock thats pulled from the Isle of Wights line could end up on the scrap heap. Others may join a heritage railway line northeast of London. And one will join the museum of the Isle of Wight Steam Railway, the islands only other train service.

We expect that it will be a popular addition, and that, in time, our visitors will be able to enjoy traveling aboard a 483 on the Island once again, says Steve Backhouse, general manager of the Isle of Wight Steam Railway. The unit will spend most of its time as a museum exhibit; however, we hope that it can run on the line during special events.

The Isle of Wight hasnt had any brand new trains since the 1800s, but thanks to a 26 million ($36 million) investment, former Tube trains from the late 1970s and early 1980s will soon arrive on the Island Line. Vivarail, a British company that designs and manufactures trains, has refurbished the carriages to make them more than just hand-me-downs. The updated D Stock will bring in free wi-fi, USB charging and, most importantly, a more reliable service.

Its sad to see the 38s go, but you can see that they are really tired now, and bless them, they need to be retired, Nix says. Its sweet that three generations of Tube trains have gone on their holidays and will see out their retirement running on the Isle of Wight.

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London's Retired Tube Trains Live on an Island - Atlas Obscura

Weinberg will run for Mercer Island City Council in next election – Mercer Island Reporter

After serving on the Mercer Island Planning Commission for the last four years, Ted Weinberg will put his hat in the ring for city council Position 4 in the November 2021 general election.

According to city site, positions 4, 2 and 6 are all subject to election in 2021. Those positions are currently held by Lisa Anderl, Salim Nice and Mayor Benson Wong, respectively.

Im running because I want to give back to the community that I love, and its given me so much over the years, said longtime Island resident Weinberg, 52, who added that hes open minded and enjoys listening to people and crafting legislation that is in the best interest of the Island.

Weinberg, whose family moved to the Island from Seattle when he was 12, noted that two of the main city issues at the forefront of his mind are fixing the underlying structural imbalance of the budget and maintaining funding for the vital mental health counselors at the schools.

During his time on the Planning Commission, Weinberg and his fellow members have helped the city work through complicated issues, including the comprehensive plan, the critical areas ordinance and the shoreline master plan, according to a press release.

While sitting on the Planning Commission, Weinberg has listened empathetically to each speaker.

Theyve got their own unique perspective in the issue that were discussing at Planning Commission that particular day. (It) affects their life in some way, either in a positive or a negative way, and they really want us to know, he said.

Mercer Island High School 1986 graduate Weinberg, who holds degrees in business from the University of Washington and architecture from the University of Virginia, has spent the last four years working as the portfolio manager for the city of Seattle Information Technology department. Weinberg and his wife have a passion for volunteering, and he serves on the boards of the Mercer Island Sister City Association and the Friends of Seward Park.

After living in Bellevue for three years during part of his 15-year career at Microsoft, Weinberg moved back to the Island in 1993 with his wife. The couple has a 26-year-old daughter and a 22-year-old son.

What I love most about Mercer Island is intelligent, dedicated and compassionate people, and its quiet, safe and beautiful neighborhoods, he said.

In consideration of how we voice our opinions in the modern world, weve closed comments on our websites. We value the opinions of our readers and we encourage you to keep the conversation going.

Please feel free to share your story tips by emailing editor@mi-reporter.com.

To share your opinion for publication, submit a letter through our website https://www.mi-reporter.com/submit-letter/. Include your name, address and daytime phone number. (Well only publish your name and hometown.) We reserve the right to edit letters, but if you keep yours to 300 words or less, we wont ask you to shorten it.

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Weinberg will run for Mercer Island City Council in next election - Mercer Island Reporter

Shutter Island: How & Why The Movie Changed The Book’s Ending – Screen Rant

Scorseses 2010 adaptation of the bestselling psychological thriller Shutter Island changed the original novels ending; we discuss how (and why).

Martin Scorseses 2010 adaptation of Dennis Lehanes bestselling psychological thriller Shutter Island changed the original novels ending, but how did the movie alter the ending and why was the change made? Released in 2003, Mystic River writer Dennis Lehanes Shutter Island is a chilling mystery with a bombshell final twist that re-contextualizes the entire preceding narrative.

The story of a US Marshall sent to investigate the treatment of criminally insane patients in the titular offshore institution, Shutter Island is a paranoid and claustrophobic story of a troubled antihero trying to uncover the truth no matter how disturbing it is. And by the time US Marshall Teddy Daniels does uncover the terrible truth behind the eponymous island, the revelation is one that casts the novels entire story in a new light.

Related: Martin Scorsese Has Two Cameos In Taxi Driver: Where to Spot

In 2010 a movie adaptation of Shutter Island was released starring Leonardo DiCaprio as Teddy and directed by Cape Fear helmer Martin Scorsese. The movie adaptation received rave reviews but changed the ending of the novel in one small but notable way. Lehanes original novel ends with the reveal that (spoilers, obviously) Teddy isnt actually investigating Shutter Island, hes a patient in the facility who was sent there after murdering his wife and children. His shattered psyche has been unable to deal with this reality, but the institutions staff go along with his delusional belief that he is investigating the island in the hopes of helping him deal with and eventually accept the trauma. However, by the novels end, Teddys condition hasnt improved despite these attempts, leading the institution to lobotomize him. In the movie, however, it is heavily implied that DiCaprio's Teddy does know the truth but hes choosing to be lobotomized as he cant face the guilt of what hes done.

The change comes down to a single line that touches on a recurring theme of both Lehanes writing and Scorseses film making: Catholic guilt. Like the lawbreakers and lawmakers who crop up in Scorseses filmography and Lehanes bibliography, Teddy is shaken by the reality of what hes done and cant contend with the thought that he is capable of such amoral evil. This inability to face the reality of his moral failings forms the bedrock of his persistent delusion that he is simply a US Marshall sent on an assignment. However, in the closing scene of Shutter Islands movie adaptation, Teddy asks his partner (actually a psychiatric doctorwho is goingalong with his delusion, played by a haunted, sad-eyedMark Ruffalo), whether hed prefer to live as a monster, or die as a good man?

This question is at the heart of Shutter Islands movie ending, whichunlike the novel heavily implies that Teddy is aware he murdered his wife and children and is intentionally choosing a lobotomy over living with that reality. The question leaves his partner shook and disturbed, as does Teddys failure to answer to the name Teddy (which further reinforces the implication that he knows this isnt his real name). The movie closes on a shot of the lighthouse where the lobotomies take place, implying that Teddy chose the procedure over living with the guilt of his actions. In contrast, unlike Scorsese's movie,thebook doesnt include the final conversation, meaning theres no real reason to think that the novels Teddy is hiding his awareness of his actions. In the original Shutter Island source novel, Teddy explicitly accepts that he murdered his wife and children, drops the delusion, and voluntarily submits to a lobotomy.

More: Which Martin Scorsese Film Has The Most F-Bombs?

Thor 4 First Set Photos Reveal Chris Hemsworth's Love & Thunder Costume

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Shutter Island: How & Why The Movie Changed The Book's Ending - Screen Rant

Waldorf Astoria’s Ithaafushi private island in the Maldives for $75,000 – Business Insider – Business Insider

If you're looking for a lush and expensive getaway distanced from other people, Waldorf Astoria's latest private island offering may be the perfect place for you.

The luxury hotel chain already has a nearby $1,700-a-night resort in the Maldives that was launched in 2019, but if you're looking for more exclusivity and luxury, head to its latest Ithaafushi private island instead.

Here, social distancing should be no problem, especially since you and whoever you travel with will be the only guests on the island (accompanied by a personal concierge team, of course).

Read more: Wealthy parents are investing in high-end, 'backyard' camp experiences and private excursions to give their kids a taste of summer in light of COVID-19

"We have launched the private island for discerning travelers during this time when we know that safety and security are a top priority amongst the evolving needs of travellers," Etienne Dalancon, general manager at Waldorf Astoria Maldives Ithaafushi, told Insider in an email interview. "The Ithaafushi private island offers a high level of exclusivity and natural social distancing. "

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Waldorf Astoria's Ithaafushi private island in the Maldives for $75,000 - Business Insider - Business Insider

Three-Car Collision Leaves One Dead on Big Island – Big Island Now

A motorcyclist lost his life Sunday in a three-vehicle crash on the Big Island.

An unidentified 67-year-old man died following the collision on Sunday afternoon, which took place at the intersection of Honomu Road.

Police responding to the 1:35 pm traffic collision determined that a 2018 Toyota Corolla four-door sedan traveling north on Highway 19 failed to yield to oncoming traffic and attempted a left turn onto Honomu Road, striking a 1973 BMW motorcycle that was traveling south on Highway 19.

Following the collision, the 2018 Toyota Corolla spun out striking a 2006 Honda Pilot, which was stopped at the Honomu Road intersection and waiting to turn right onto Highway 19.

The motorcycle operator was unresponsive at the scene and transported to Hilo Medical Center where he was pronounced dead at 4:24 pm. An autopsy has been ordered to determine the exact cause of death.

The driver of the Honda Pilot, a 39-year-old man from Kona, and his three passengers, a 35-year-old woman, a 13-year-old boy, and an 11-year-old girl, all from Kona, were not injured in the crash.

The driver of the Toyota Corolla, a 59-year-old man from Honomu, was transported to Hilo Medical Center with abrasions and later released. He was then arrested for negligent homicide in the second degree and released pending further investigation.

Police investigating the traffic collision have determined that inattention to driving and failure to yield were major contributors to the crash. Alcohol and/or drugs are not considered factors at this time.

This is the third fatal traffic collision in 2021 compared to three fatal traffic collisions during this same time period last year.

The East Hawaii Traffic Enforcement Unit is conducting this investigation and is asking anyone who may have witnessed the accident or has information to contact Officer Erhard Autrata at (808) 961-2329 or via email [emailprotected].

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Three-Car Collision Leaves One Dead on Big Island - Big Island Now

The little island of Procida prepares to shine as Italys Capital of Culture – The Guardian

Church bells chime and children play freely in the square named after the late actor Massimo Troisi. A restaurant serves fresh fish to the smattering of customers eating outside, and fishermen mend their nets. With clear blue skies, it seems like a typical afternoon in mid-summer.

But this is late January in Corricella, a 17th-century port in Procida, and the scene pretty much sums up the pace of life on what is the smallest and least known island in the bay of Naples.

Parts of Troisis 1994 Oscar-winning Il Postino were filmed in Corricella, and the area shot to fame again a few years later as the fictional village of Mongibello in The Talented Mr Ripley. Both films helped raise Procidas profile, but not enough to keep the majority of visitors from overlooking it in favour of the glamorous Capri or Ischia, popular for its natural hot springs.

Now the colourful Mediterranean island has been thrust back into the limelight after recently winning the coveted accolade of Italys Capital of Culture for 2022, fending off competition from nine other candidates. It is the first time that the title has ever been granted to an island.

The prize was a moment of celebration among the islands 10,000 inhabitants and gave a glimmer of hope for the future amid Italys ongoing struggles with the coronavirus pandemic. Giuseppe Conte, the countrys caretaker prime minister, said: Lets get ready to visit Procida, while culture minister Dario Franceschini said the island would accompany us in the year of rebirth.

But some residents, wary of the pre-Covid mass tourism that has blighted so many other cultural treasures in Italy, say a balance must be struck between developing the island and maintaining its cherished characteristics.

Its a good thing for the island and important for the generation who will come after us, said fisherman Francesco Scotto. But we need to be cautious. Tourism is OK but if it becomes too frenetic, like Capri or Ischia, we risk losing our traditions.

Those centuries-old traditions are closely tied to the ocean. Scotto is among the many islanders who would be at sea for months on end, working in commercial shipping or, in more recent decades, in the cruise ship trade.

Whoever works at sea always has a desire to return to Procida, said Scotto, who was born and raised on the island. It is here we find tranquility.

Luigi Esposito, who runs a furniture restoration shop, said many seafarers have long resisted tourism. They would come home and want peace, not to see crowds of people, he said, while describing Procida as a magnet you never want to leave.

The community is close, like one family, he added. But Procida is also an island that needs to progress with balance and care.

Raimondo Ambrosino, the mayor of Procida, said the island is ready for the challenge as leaders work up a rich calendar of events for 2022 that will draw on its history, art, music, food, architecture and natural beauty.

Procida is just 4km-wide and made up of pastel-coloured houses, several beaches and narrow alleyways that wind through the main town. Overlooking Corricella harbour is the old walled town of Terra Murata, home to a disused prison that until 1988 hosted some of Italys most violent criminals. Guided tours of the prison began in 2016, and leaders are now trying to establish how to make best use of the vast building.

Procida is also home to a maritime academy, attracting students from beyond the island.

A key element of the islands winning bid was its development of slow tourism, Ambrosino said.

The island gets busy in the summer, especially with Neapolitans, but the visitor numbers have so far been sustainable. Ambrosino expects this to continue as foreign visitors return after the pandemic.

Procida is not an amusement park, he said. You wont find nightclubs or big luxury hotels with spas. What you will find is a particular experience people dont come here to be entertained but to get to know the community and its traditions.

In Corricella, Giuseppina Nasti is clearing tables at La Locanda del Postino, a restaurant that in its previous life was the storage space used to create the bar and restaurant in Il Postino. Procida is part of the Campania region, which is currently under yellow zone Covid restrictions, allowing bars and restaurants to open until 6pm.

My dad travelled all over by sea and used to say that Procida was the most beautiful place in the world, Nasti said. When he retired, he didnt want to leave again. Procida is much more authentic than Capri or Ischia.

Ambrosino doesnt believe that Procidas recent victory will diminish that authenticity.

There is a risk that the island could change, but its also true that for centuries its had a strong maritime identity its difficult to imagine that this would suddenly be turned upside down by the fame, he said.

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The little island of Procida prepares to shine as Italys Capital of Culture - The Guardian

Practitioner shares passion for integrative healthcare with Camano Island | HeraldNet.com – The Daily Herald

Focused on a traditional career in medicine since he could walk, Dr. Bryan Cooper had his a-ha moment while working as a hospital corpsman in the Navy. There he experienced firsthand the power a nursing career holds, an experience that demonstrated the humanity in medicine and set the precedent for his practice.

The concept wasnt new to Dr. Cooper, who grew up seeing his grandparents both chiropractors treating several generations of patient families. That experience, paired with his own, has informed his own practice at Camano Island Health System.

In my practice, Ive taken a different approach to medicine because I want to be able to build partnerships with my patients its enormously rewarding to be able to get to know and grow with them. Locally owned and operated, weve brought a mom-and-pop feel to our practice which isnt something youre likely to find elsewhere, Dr. Cooper explains.

By educating and empowering patients and their families, the practice is bringing everyone in the community a means of pursuing optimal health.

Who they are:

Camano Island Health System is a doctorate-level, nurse practitioner-led healthcare organization that serves the Camano Island community with high-quality health services.

Caring for the whole person and using an integrated approach underscores their work, allowing them to provide exceptional care.

By combining complimentary types of treatment, such as family practice, psychiatry, acupuncture and massage in a respectful environment, it allows fellow practitioners to work together for the betterment of the patient.

This comprehensive approach prevents duplicate or contradictory messaging and also presents the patient with a full range of care options. It also provides a bigger pool of resources beneficial for patient safety, as all treatment methods are explored comprehensively.

In a profession that changes daily as we discover new things and studies are released, its important to always be able to learn and adapt to the changing environment, and having this interactive approach affords us this, Dr. Cooper says.

Core services offered at CIHS include:

Through comprehensive, integrative, quality health services, Camano Island Health System is helping meet the needs of the Camano Island communities.

To learn more, visit them online at camanoislandhealth.com. You can also head to Facebook, Instagram, or Twitter to stay up to date on all their latest happenings.

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Practitioner shares passion for integrative healthcare with Camano Island | HeraldNet.com - The Daily Herald

Oceanside, Island Park hit with massive nor’easter – liherald.com

By Scott Brinton and Mike Smollins

A massive nor'easter out of the west swept across Long Island early Monday, and prognosticators say it could drop up to a foot or more of snow across the area by Tuesday, with wind gusts expected to reach 30 to perhaps as high as 60 miles per hour.

Oceanside and Island Park were two areas hit hard by the storm. Both of the school districts closed ahead of the winter blast on Sunday and announced Monday that they would also be closed on Tuesday. Messages stated that the Oceanside and Island Park school district websites would update residents on more closures or potential re-openings for later in the week.

Nassau County and town officials urged people to stay off the roads during the storm if they could. Road conditions were already "treacherous" by Monday morning.

"Wind is going to play a signifcant role in this storm," said County Executive Laura Curranduring a news conference Sunday. "We're talking about blizzard-like conditions .... It's going to be heavy, wet snow with a lot of wind."

The biggest snow fall will come between 10 a.m. and 11 p.m. Monday. The South Shore is expected to be "most vulnerable," the county executive said.

"As the day goes on, conditions are going to get more dangerous for driving," Curran said.

Two to five inches were expected to fall by the time of the morning commute at 9 a.m., and snow was expected to accumulate throughout the day after that.

For your hyperlocal forecast by zip code, seethe National Weather Service here.

Power outages were expected. To report one, go toPSEGliny.com.

Expect delays and service disruptions on the Long Island Rail Road and NICE Bus.

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Oceanside, Island Park hit with massive nor'easter - liherald.com

Swedish nurse to be sole attendee of film festival on remote island – The Guardian

Scandinavias biggest film festival is going ahead this year despite the coronavirus pandemic, but will be hosted on an isolated island and admit only one attendee a healthcare worker, who has been selected from 12,000 applicants.

Lisa Enroth, a Swedish nurse and film fan, was chosen to be the 2021 Gothenburg film festivals castaway who will spend a week on the remote island of Pater Noster watching film after film.

In healthcare I seem to have spent ages listening, testing and consoling. I feel like Im drained of energy, Enroth said.

Pater Noster, on the boundary of a dense archipelago off Swedens west coast, is known for its lighthouse.

The wind, the sea, the possibility of being part of a totally different kind of reality for a week all this is really attractive, said Enroth, who will keep a daily video diary that will appear on the festivals website.

The festivals chief executive, Mirja Wester, said: It feels particularly right to be able to give this unique experience to one of the many heroes of the healthcare system who are all working so hard against Covid-19.

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Swedish nurse to be sole attendee of film festival on remote island - The Guardian

Washington home by Graham Baba embraces its forested island setting – Dezeen

A lake house in the Pacific Northwest has received a complete overhaul by American studio Graham Baba Architects, creating a "quiet refuge" that prioritises views of the water.

The Lakeside Residence is nestled into a sloped site on Mercer Island, surrounded by a freshwater lake just east of Seattle.

The project involved the full revamp of a 1960s beachfront cabin that underwent a series of piecemeal renovations over the decades.

"By the time our client acquired the house, its design integrity had long ceased to exist," said Seattle firm Graham Baba Architects.

"The forested property, however, was ideally suited to the creation of a quiet refuge with direct connections to nature."

The building was stripped down to its studs, and the interior layout was completely rearranged. A key goal for the design team was to provide a strong visual connection to the lake, which the original dwelling lacked.

The architects sought to make the most of a somewhat challenging site, which slopes down toward Lake Washington. The terrain drops a total of 60 feet (18 metres).

Great attention was placed on the entry procession, which begins with a driveway that winds through the woods and arrives at a carport located uphill from the house.

A walkway travels down through intimate gardens and terminates at the home's entrance, which is marked with a double-height glass wall. Glimpses of the lake can be seen through the glazed aperture.

"The passage from street to house is conceived as a journey, where work and public life gives way to nature and private reflection," the team said.

Roughly rectangular in plan, the home is clad in dark-stained cedar that provides "subtle dimension and shadow effects."

In certain parts of the exterior, the team incorporated Corten steel siding to help articulate the home's massing.

Large stretches of glass lend a sense of transparency to the dwelling and usher in ample daylight. On west-facing windows, sunshades and fins help mitigate direct sun exposure. Roof plantings atop the house help the building blend with its verdant setting.

Within the residence which has two levels and a basement one finds rooms awash in neutral colours and earthy materials. Many of the spaces are oriented to provide expansive vistas of the water.

The ground floor contains the entrance, a galley kitchen with a breakfast nook, an open-plan living and dining area, and a guest room.

Rooms are fitted with contemporary decor that is both streamlined and comfy. In the main living space, bi-fold doors lead to a patio that pushes out toward the water.

The second floor holds a generous master suite and two bedrooms for children. Special features in the master suite include a Japanese soaking tub and sliding pocket doors with leather panelling.

"Concealed doors and integrated handrails reinforce the minimal aesthetic without sacrificing rich materiality," the team said.

A variety of spaces are located in the home's lowest level, including a den, playroom, exercise room and wine cellar.

"Previously closed off from the waterfront, the basement now opens directly to the waterfront, enabling activities to flow from inside to outside," the architects said.

Throughout the dwelling, the team aimed for "crisp and spare detailing." Warm materials, such as fumed white oak, are paired with industrial finishes like polished concrete and blackened steel. No detail was overlooked.

"Everything from door pulls to sink faucet levers were meticulously designed, detailed and fabricated," the team said.

Founded in 2006, Graham Baba Architects has completed a number of distinctive projects in the Pacific Northwest, ranging from a moody speakeasy at Amazon's Seattle campus to the rural headquarters for the Washington Fruit and Produce Company.

The firm also designed a Seattle cannabis dispensary that features dark metal cladding, wooden decor and glass vitrines.

Photography is by Kevin Scott.

Project credits:

Architect: Graham Baba ArchitectsArchitecture team: Brett Baba, design principal; Francesco Borghesi and Noreen Shinohara; project teamInteriors: Terry HunzikerCivil engineer: CPLStructural engineer: Carissa FarkasGeotechnical engineer: Geotech ConsultantsLandscape architecture: Rich Haag and Associates, Anne James Landscape ArchitectLighting design: Brian HoodContractor: Lockhart Suver

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Washington home by Graham Baba embraces its forested island setting - Dezeen

Rock Island woman faces felony charges after 3 injured in Bettendorf bar fight – WHBF – OurQuadCities.com

A 30-year-old Rock Island woman faces felony charges after a Bettendorf bar fight left three people injured.

Rebecka Castaneda-Valadez faces three counts of assault while displaying a weapon and three counts of willful injury, all felonies.

The fight happened shortly before 2 a.m. Jan. 10 at the Central Avenue Tap, 2604 Central Ave., the arrest affidavit says. Castaneda-Valadezs sister and her sisters boyfriend got into an argument, which led to a fight.

Castaneda-Valadez, without apparent provocation, grabbed a glass beer bottle and struck the bar owner in the back of the head with it, breaking the bottle.

After that, Castaneda-Valadez cut another victim with the bottle while the second victim tried to break up the fight, the affidavit says.

A third victim was fighting with the defendants sister and also was cut with the bottle by Castaneda-Valadez.

The three victims were transported to different hospitals with these injuries:

Victim one: A large cut to the back of the head that was bleeding profusely from being struck by the beer bottle.

Victim two: A large cut underneath her right eye and a large deep cut over her right eye. Both injuries were bleeding profusely when police officers arrived. She advised an officer she would need surgery in Iowa City for the wound above her right eye.

Victim three: A large, deep cut to her left ring finger, swelling above her left eye and had a small cut on the left side of her back. The cut to the victims finger and her back had been bleeding when Bettendorf police arrived.

Witnesses identified Castaneda-Valadez as the person who had struck and cut all three victims, who independently identified her from a photo lineup.

Witnesses also identified a codefendant, Sean Wren, 31, as being involved in the fight, too. The third victim said he struck her multiple times in the face while Castaneda-Valadez assaulted her.

Castaneda-Valadez, arrested on a warrant, was released on bond after being held 33 minutes Saturday night in Scott County Jail. She is scheduled to appear Feb. 15 and again Feb. 19 in Scott County Court.

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Rock Island woman faces felony charges after 3 injured in Bettendorf bar fight - WHBF - OurQuadCities.com