Greys Anatomy: 5 Shameful Things April Did (& 5 She Should Be Proud Of) – Screen Rant

On Grey's Anatomy, a lot of the characters have complex arcs. However, April Kepner seems to be one that has plenty of ups-and-downs.

When actress Sarah Drew joined the cast of the hit medical drama Grey's Anatomy way back in season 6, she wasn't a raging fan-favorite. Between seasons 6 and 8, she didn't get much character development. That didn't occur until season 9.

RELATED:Grey's Anatomy: What Your Favorite Character Says About You

April Kepner was a character that evoked polarizing opinions in fans but, gradually, she made a place for herself on the show and even became beloved over the years. Fans stayed with this relatable trauma surgeon, but being the epitome of sweetness didn't mean that she never did anything she shouldn't be ashamed of.

April was devastated by the death of her son, Samuel Norbert Avery, who survived only a few hours after being born with Type II Osteogenesis Imperfecta.

Although she was completely justified in seeking a change of scene after the tragedy, some fans believed this lack of communication was the first sign of her and Jackson's marriage dwindling. She left for Iraq soon after and kept extending her tour.

Then, when she returned, she was ready to talk and fight for their marriage. This did seem a little unfair on Jackson, who had just begun processing his own feelings and grief after suppressing them for so long.

In season 14,April was seen to go througha crisis of faith when she began to feel that life was thoroughly unfair and that good people were suffering terribly for no good reason. For some time, she was unable to connect with God or find comfort in her faith.However, after talking to a rabbi, she eventually managed to find the answers she needed, which helped her put her life back together. Getting past such a crisis took great strength, which is something she should be proud of.

While April was still doubting God and everything she had grown up believing in, she would often behave uncharacteristically with her colleagues.

RELATED:Which Grey's Anatomy Character Is Your Soulmate, Based On Your Zodiac?

In the episode, One Day Like This, this is where April met the rabbi, Eli,who was in unimaginable pain from a skin condition he had developed from some antibiotics Bailey had prescribed. His situation was extremely rare and Bailey could not have guessed that her meds would backfire.

However, April, in her disillusioned state of mind, was surprisingly mean. She yelled at Baileyfor being negligent and made her feel ten times more guilty than she already was.

April enlisted in the army and went to Iraq with her mentor Owen as a way to heal after losing her baby son tragically. For someone who is usually so meek and docile, April was the last person fans expected to enlist. However, this didn't stop them from admiring her courage and bravery, especially as she served two tours and used the skills she learned in Jordan to help on her future cases.

Before April Kepner had become a firm fan-favorite and sometimes even afterward, she was rather annoying with her cloying sweetness and nagging.

In fact, not all the doctors liked her as Bailey made clear multiple times. Except for Jackson and Arizona, who became a good friend, later on, April didnt have a lot of friends at the hospital, simply because she drove people crazy with her irritating ways, however well-intentioned.

Seattle Grace was going bankrupt after the doctors, including Derek and Meredith, sued it for negligence after the shocking season 8 finale.

RELATED:Greys Anatomy: Every Season Finale, Ranked

At this time, the hospital had decided to give up its ER to cut down on expenses. Since the ER was the place where the most serious cases would arrive, it would have been a travesty to close it down. At this time, April invested a lot of time and energy, alongside Derek, to figure out a way to save the ER as well as the hospital.

April was one of the most conscientious doctors at Seattle Grace/Grey Sloan Memorial. However, when she was still an intern from Mercy West, she made a mistake that cost a woman her life.

The mistake was simple enough. April got distracted when a flood of severe trauma patients arrived following a major fire. She forgot to check a patients airway and intubate her, which ultimately led to the patients death. Although she didnt do it intentionally, this was by far one of the worst things April did in her career.

April Kepner was in a massive car crash in season 14 with her boyfriend, Matthew with whom she had got back together after splitting from Jackson.

The doctors at Grey Sloan Memorial were apprehensive as to whether or not she would make it, but almost by some miracle, she did. This incident was in fact the final thing that made April overcome her struggle with her faith.

Another rather shameful thing April did was to leave Matthew at the altar and elope with Jackson.As fans remember, April found herself embroiled in a love triangle after the trauma surgeon found herself torn between Jackson and Matthew.

RELATED:Grey's Anatomy: Every Wedding Episode, Ranked (According To IMDb)

While she did have feelings for Jackson, April decided to go ahead with her wedding to Matthew after the plastic surgeon rejected her. Then, when her wedding day arrived, Jackson decided to confess his feelings and the two ran out of the church together. Many fans that she didnt need to break Matthews heart quite so spectacularly.

April became a formidable trauma surgeon over the years, a specialty one wouldnt normally have associated with someone as sensitive as her.

She had grown up on a farm and got through several obstacles, which included getting fired twice, failing her boards,a crisis of faith, as well as the death of her son. In spite of all that, she emerged as a good surgeon, something she should most definitely be proud of.

NEXT:10 Greatest Life Lessons Fans Learned From Grey's Anatomy

Next The Office: Why Roy Was Better Off Without Pam (& Why He Should Have Stayed)

Surangama, or Sue, as she is called by many, has been writing on films, television, literature, social issues for over a decade now. A teacher, writer, and editor, she loves nothing better than to curl up on a lazy afternoon with her favorite book, or with a pen and a notebook (a laptop would have to do!) and a foaming cuppa tea on the side.

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Anatomy of the Ideal Email – mySanAntonio.com

Would you introduce yourself to a client without bathing, without combing or with shoes in two different colors? The way you write your email is part of your extended image , just like your social networks, your car, your office or the background of your Zoom meeting. They say a lot about you, and make a favorable or unfavorable impression that can result in different attitudes and results.

Take the number 236 and then add nine zeros. It's a gigantic number: 236,000'000,000. Two hundred thirty-six billion emails are sent every day around the world. The vast majority of these are business emails.

But not all emails are the same. Some are better than others - they are well written and serve their purpose effectively and elegantly.

How many emails do you write per day? How many do you get? Do you want to take your emails to the next level?

In most emails, we develop the content and only think about the "subject" or title of the email until the end. The amount of emails with definitely boring, generic or useless subjects is impressive.

The subject is the first thing the person receiving the email sees: it is what is in their inbox and what helps them decide whether to read that email in the moment, leave it for later or, outright, send it to the trash can.

Avoid generic titles like "hello" or "I hope this interests you." Whether it's for clients or partners, prefer a title that talks about content without being highly technical. Do not write either: "Subject: P 44518 11/21/2020"

Instead, write: "Subject: South grid budget, November 21, 2020", or "Work plan, Madrid trip", or "Promotions for printing, July 2021."

Think short, clear, informative, and engaging. Don't leave it to chance!

E-mail is done digitally, but it is still, at its core, a message between two people, two human beings who like to be treated as such. The least we expect - and rightly so! - is a friendly and personalized greeting and farewell.

Avoid generic greetings, which "feel" forced or said in a hurry. Whenever you can, address the recipient by their first name, saving, if applicable, the protocols and titles: doctor, teacher, professor, etc.

The farewell, like the entrance, should set the human and cordial tone without abusing clichs and clichs. You can add some personal detail ("Say hello to Marcia, your wife", or "I hope you are getting comfortable in Monterrey") that generates a greater connection and greater trust.

Today's networks are created and reinforced with each message. Take advantage of each email to connect with people; not just to convey information or get out of trouble.

That said, emails are not made to convey huge amounts of information. Nobody wants to read an entire novel in their inbox, or on their cell phone between meetings!

Keep the content short and to the point, using dots or numbers to sort the ideas if necessary. An email should be no more than two or three paragraphs long. Five? Okay, but no more than that.

If there is more to include in the same shipment, I recommend you keep the content of the text short, and add a document with the complete information: it is easier to print, read and share. Everyone hates excessively long emails; especially if they are part of a longer chain.

Never (but never) try to resolve a problem, discussion or complex issue through emails. The written word can never encapsulate the details of a live conversation or, even more, a meeting. In the middle of an argument, written words are easily misunderstood, and in a complex project, the same will happen. Better pick up the phone, fix the problem, and finally send a short email with the agreements reached.

Everyone hates excessively long emails / Image: Stephen Phillips - Hostreviews.co.uk via Unsplash

Remember: a written communication is a mechanical substitute for a real conversation, between two real people, with their real characteristics and circumstances. That is why there is no single correct shade, no single style. You would not talk the same with your boss as with a client, with a friend or with a colleague.

Are you talking about "you" or "you"? Do you greet him formally or with familiarity? Are you overly serious, or too casual? Try to imagine that you are in the same room, how would you do it then? Try to imagine what information he would need and find the best way to say it. And of course: say it well.

Bad spelling is bad business breath. No one will tell you, but trust me: everyone notices.

By the way: an email is not an SMS. An email does not admit misspellings or simplified language (at least, not in a business environment). Take care of your spelling and syntax: write correctly and completely and save the emojis and contractions for another time. Completely avoid WRITING WITH CAPITAL LETTERS and do not abuse the exclamation marks !!!!!!!!!!

Oh, how much trouble we could avoid if people reread what they just wrote! Not only to correct the spelling or complete what is missing, but above all to understand if the message makes sense , that is, if it is clear and concise in all its points.

In important emails, I recommend that you read the email aloud , to "prune" the text and eliminate the too confusing, long or unnecessary parts. Sometimes, for the sake of looking "formal," we overcomplicate things that may be simple.

Nine times out of ten, a new read before sending will help you find areas for improvement and (sure!) Embarrassing mistakes that would look terrible on your customer's tray.

By last

It's a bit ... amateur , don't you think?

Related:Anatomy of the Ideal EmailAnatoma del correo electrnico idealFree Webinar | Feb 23: How to Turn a Side Hustle into a Multibillion-Dollar Marketing Platform

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Grey’s Anatomy: The Worst Episode Of Every Season (According To IMDb) – Screen Rant

Grey's Anatomy is one of the most successful shows on television, but which episodes were the least successful of each season?

For 17 seasons, Grey's Anatomy has taken viewers on a wild ride through two hospitals, countless marriages, divorces, and one night stands. The show has put audiences through many emotions of laughter, sadness, joy, and pain. With over 360 episodes, viewers will without a doubt have their favorites.

RELATED:Grey's Anatomy: Each Role The Main Characters Could Play In Another TV Drama

However, the good folks over at IMDb have their own list of high and low-ranking episodes. Whilemanyfans of Grey'smight argue with this list, the fact remains that even one of the best shows has dropped the ball a few times in terms of storylines.

Meredith is pressing issues with Derek as their relationship grows, but Derek is still not providing much insight into his personal life.

Cristina, not one for the whole family vibe, is having a hard time dealing with her pregnancy. Alex is trying to convince a young patient that a particular surgery could actually save her life.

George and Callie are an item but no one knows this. They're still sneaking around, but Izzie catches wind and wants all the details.

Preston Burke, as great as he is, is showing nerves when he has to operate on one of his idols. Meredith is contemplating a date with Finn,while Addison and Derek are trying to work things out.

Cristina and Burke's mothers are in town to plan what was supposed to be the dream wedding. Addison is dealing with a typical Grey's Anatomy love fiasco which involves her, Derek, Mark Sloan, and Meredith.

RELATED:Grey's Anatomy: 10 Main Characters' Biggest Flaws & Best Redeeming Qualities

Addison decides to leave town, which results in what would soon become the first Grey's Anatomy spinoff,Private Practice.

Izzie and George are exploring their newly intimate relationship. Derek and Meredith are back in the swing of things, and Mark is ready to make a move on Erica. Love is everywhere (or instant hookups are).

Meredith is trying to come to terms with the sister relationship she has with Lexie, so she warns Alex about their encounters.

Christian is still showing no signs of respect for Meredith's and Derek's relationship. But then fate steps in and Christian begins to feel left out.

Cristina begins to worry if Lexie is hurting herself on purpose and wants nothing to do with her in the OR. Webber is trying to woo Dixon to work at Seattle Grace, but Bailey is not convinced she's the proper fit.

Callie wants a family with Arizona but at the time, Arizona is more focused on her career, and. Mark's daughter is ready to deliver the baby but then has second thoughts concerning the adoption process.

RELATED:Grey's Anatomy: 5 Things The Highest-Rated Episode Did Wrong (& 5 Things The Lowest-Rated Did Right)

Jackson puts April on the spot regarding how much she admires Derek. Arizona questions the decision-making of Sloan, which causes conflict between her and Callie.

The fallout from the accident is on full display here. Callie's life is hanging in the balance, but not just hers, the baby's as well. The staff is doing their best to save both the mother and child that but the stress is taking its toll.

Addison is flown in and sides are taken. Mark and Arizona draw a line in the sand regarding Arizona's place in Callie's and their baby's lives.

The day started off great, but what can go wrong on Valentine's Day for the staff at Seattle Grace?

Owen and Cristina continue their drifting apart. Meredith and Derek are struggling to get some alone time. Callie and Arizona are planning for a trip, and Ben and Miranda have plans of their own.

A magician is on the scene after almost cutting his assistant in half. Arizona doesn't know it, but she's the object of another doctor's crush. Owen and Cristina are still going through the motions.

RELATED:Grey's Anatomy: 10 Main Characters' Arcs, Ranked Worst To Best

Cristina is not convinced that Owen has just abandoned his plans for having a baby. Miranda just wants to be left alone and is hiding from everyone.

Halloween time is here, and that's where the super weird stuff goes down.

Patients are biting one another, Webber is handing over an important surgery to residents, and the grown-ups on the staff can't decide what to wear to a party. Can the doctors get past their personal issues and enjoy themselves?

This is the episode where the hearts of Grey's Anatomy fans were broken. Derek is a witness to a car accident and does the right thing by helping out.

He saves a life but gets in his car, and one second was all it took to take away one of the best characters in the history of the show. Derek is rushed to the hospital where a mistake was made that cost him his life.

In the midst of going through their divorce, Grey's Anatomy paid homage to one of the best couples on the show.

April and Jackson have been through enough in their short time together to rival the bond of any union at Seattle Grace or Grey Sloan Memorial. It's an episode of how they got to where they are now.

Jackson and April travel to Montana to perform a surgery at one of his mother's hospitals, only to encounter his father at a bar. Jackson has some questions, but it's what happens between him and April that had fans swooning.

RELATED:Grey's Anatomy: 10 Most Overdone Storylines

There was a chance at reconciliation between the two, but both parties pulled back before they had a chance. The road trip gave time to hash out issues but, in the end, it wasn't enough.

Maggie and Jackson are busted by Richard and Catherine. April is spinning out of control and when Jackson tries to find out what the cause is, she kisses him.

Meanwhile, Owen and Amelia are going through their issues, as Owen returned from a trip to see Teddy, but Amelia has labeled him a cheater.

Deluca's dad makes a visit to the hospital in order to pitch a new idea to Grey Sloan Memorial Board.

Niko and Levi are at that stage in their relationship where they have to decide to stay hidden or come out to their families. Maggie lets the truth be known to the world that she is the love child of Richard Webber and Ellis Grey.

No death, but Grey's loses a popular character. Alex leaves letters for the important people in his life and explains why he decided to not only leave the hospital, but Seattle altogether.

It would be revealed that Alex and Izzie Stevens have reconnected, and Izzie had Alex's children.

Meredith is still sick. Bailey is still grieving the loss of her mother, and Teddy is still begging Owen for forgiveness.

But to top it all, Opal comes back in some weird crossover attempt with Station 19. Meredith gets a sudden moment of energy, but that does not last long and before the episode ends, and she's in worse shape than ever.

NEXT:Grey's Anatomy: 5 Characters Who Give The Best Romance Advice (& 5 Who Give The Worst)

Next 10 Most Unlikely Friendships On TV

Mark Wilson has his favorites TV Shows. We're talking The Blacklist, The Chi, all the Chicago One dramas and many more. He spends his spare time writing, watching, and traveling to events as a credentialed member of the media.

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Where to Stream ‘This Is Us,’ ‘Grey’s Anatomy,’ & Other Shows Given the Post-Super Bowl Time Slot – TV Insider

Even if youre not a football fan, Super Bowl on Sunday, February 7, has plenty for you to enjoy, from its commercials to the highly anticipated (or just much-hyped) TV show that airs right after the big game, whether a new episode or a series premiere.

This year, the prime CBS slot goes to the premiere of The Equalizer starring Queen Latifah, which then moves to its regular Sunday night time slot of 8/7c the following week. If you cant catch its first episode on the 7th its 10/9c time period is approximate, and depends on when the Kansas City Chiefs and Tampa Bay Buccaneers finish playing dont worry, it streams on CBS All Access the next day.

Over the years, the other shows given the coveted post-Super Bowl slot have included new episodes of Greys Anatomy and The Blacklist, and the premiere of shows including Family Guy. And now, some of these high-profile episodes are available to stream. To find out which ones are and where, check out our guide below.

2006: Greys Anatomy, Its the End of the World (Season 2, Episode 16)

2007: Criminal Minds, The Big Game (Season 2, Episode 14)

2011: Glee, The Sue Sylvester Shuffle (Season 2, Episode 11) (also Amazon)

2014: New Girl, Prince (Season 3, Episode 14)

2015: The Blacklist, Luther Braxton (Season 2, Episode 9)

1988: The Wonder Years, Pilot (Series Premiere)

1997: The X-Files, Leonard Betts (Season 4, Episode 12)

The X-Files (Jack Roland/Fox Network/Courtesy Everett Collection)

1999: Family Guy, Death Has a Shadow (Series Premiere)

2000: The Practice, New Evidence (Season 4, Episode 12)

2001: Survivor: The Australian Outback, Stranded (Season 2 Premiere) (also CBS All Access)

2002: Malcolm in the Middle, Company Picnic (Season 3, Episodes 11 & 12) (also IMDb TV)

2004: Survivor: All-Stars, Theyre Back! (Season 8 Premiere) (also CBS All Access)

2005: American Dad, Pilot (Series Premiere)

2010: Undercover Boss, Waste Management (Series Premiere) (also CBS All Access, Peacock, Amazon)

2013: Elementary, The Deductionist (Season 1, Episode 14)

2014: Brooklyn Nine-Nine, Operation: Broken Feather (Season 1, Episode 15) (also Peacock)

2017: 24: Legacy, 12:00 PM 1:00 PM (Series Premiere)

2018: This Is Us, Super Bowl Sunday (Season 2, Episode 14)

2020: The Masked Singer, The Season Kick Off Mask Off: Group A (Season 3 Premiere)

Brooklyn Nine-Nine (Eddy Chen / Fox / courtesy Everett Collection)

1998: 3rd Rock from the Sun, 36! 24! 36! Dick (Season 3, Episodes 14 and 15) (also Peacock)

2002: Malcolm in the Middle, Company Picnic (Season 3, Episodes 11 & 12) (also Hulu)

2003: Alias, Phase One (Season 2, Episode 13)

2008: House, Frozen (Season 4, Episode 11) (also Peacock)

2010: Undercover Boss, Waste Management (Series Premiere) (also CBS All Access, Hulu, Peacock)

2011: Glee, The Sue Sylvester Shuffle (Season 2, Episode 11) (also Netflix)

2001: Survivor: The Australian Outback, Stranded (Season 2 Premiere) (also Hulu)

2004: Survivor: All-Stars, Theyre Back! (Season 8 Premiere) (also Hulu)

2010: Undercover Boss, Waste Management (Series Premiere) (also Peacock, Hulu, Amazon)

House (Adam Taylor / Fox / Courtesy Everett Collection)

1984: Airwolf, Shadow of the Hawke (Series Premiere)

1998: 3rd Rock from the Sun, 36! 24! 36! Dick (Season 3, Episodes 14 and 15) (also Amazon)

2008: House, Frozen (Season 4, Episode 11) (also Amazon)

2009: The Office, Stress Relief (Season 5, Episodes 14 & 15)

2010: Undercover Boss, Waste Management (Series Premiere) (also CBS All Access, Hulu, Amazon)

2014: Brooklyn Nine-Nine, Operation: Broken Feather (Season 1, Episode 15) (also Hulu)

1999: The Simpsons, Sunday, Cruddy Sunday (Season 10, Episode 12)

2005: The Simpsons, Homer and Neds Hail Mary Pass (Season 16, Episode 8)

Friends ((c)NBC/courtesy Everett Collection)

1996: Friends, The One After the Super Bowl (Season 2, Episodes 12 & 13)

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Where to Stream 'This Is Us,' 'Grey's Anatomy,' & Other Shows Given the Post-Super Bowl Time Slot - TV Insider

Anatomy of a Growing Recall: The People vs. The Governor of California – Jewish Journal

In California, its tricky to predict earthquakes, but it appears a big one is coming, and its threatening to topple Governor Gavin Newsoms political career.

Though usually pretty laid-back, suffering citizens in the Golden State are translating their upset at state mismanagement during theCOVID-19 pandemicinto a rapidly growing recall movement that is poised to shake thepolitical landscape of our nations most populous state.

Californias recent surge into the epicenter of coronavirus deaths follows months of hospital overcrowding, a poorly executed testing system, sharply rising unemployment, insurance fraud at taxpayer expense and an excruciatingly slow rollout of vaccinations for desperate health care workers and the vulnerable elderly.

For months, citizens have been treated to inconsistent andincomprehensible top-down rules from Sacramento banning religious services (while liquor stores remain open) but allowing lines at grocery stores (while outside restaurant dining and even beaches and parks have been opened and closed and opened again).

For months, citizens have been treated to inconsistent andincomprehensible top-down rules from Sacramento.

Families are reeling from economic devastation, and many children aresufferingdeclining educational results and mental health crises.Millions are out of work and facedwindling savings, with a looming cut-off of workers compensation insurance.

As residents approach the one-year anniversary of the pandemic in the state with the strictest stay-at-home lockdowns,parents, students, workers and shopkeepers from everyethnicity, social class and walk of life aregrappling with the immense pain of lost lives, jobs, family savings, and schoolsemesters. And they aremoving from annoyance to distrust to contempt for a governing class that appears both incompetent and deeply elitist. In my priorpiecefor the Journal, I detailed that the states policies and unaffordability have even been driving a wave of emigration.

People dine along 5th Avenue in the Gaslamp Quarter before an imposed curfew on November 21, 2020 in San Diego, California. (Photo by Sandy Huffaker/Getty Images)

While Governor Newsomisnt solely responsible for the high cost of living and declining quality of life in California, he seems to epitomize the do-as-I-say-not-as-I-dotone-deaf attitude that irks the citizenry. The problem with his now-infamous fancy dinner party at French Laundry in November 2020 isnt just the casual hypocrisy of swanky indoor dining without wearing a mask; it is hiscontroversialchumminess with hispay-to-playinsider lobbyist hosts.

As the Governor, the buck stops with Newsom, and he is likely to pay the price as the public finally catches on to the fatal flaw of contemporary statism elected leadership is far more responsive to special interests than to the people.

For most of American history, political organizing of public employeeunionswas illegal,and good government advocates have consistently cautionedagainstunions capturing elected officials.

Unions raise funds from mandatory membership dues and then contribute large election campaign contributions.In return, they expect favorable legislation and massive budget allocations for their members salaries, benefits and pensions.

Government reform expertDavid Crane has been leadingeffortsto promote the general interest of the public, not the single interest advocacy ofpublicemployee unions

For example, thestate provideshealth insurance to active government employees. But unlike most employers,the State also provides health insurance to retired employees and their dependents, even when the retiree or dependent has another job that offers insurance, is covered by Medicare or is entitled to premium support from the Affordable Care Act or the California State Premium through Covered California, which provides the highest levels of premium support in the country.

The total amount of taxpayer liabilities for state employee salaries, health care benefits and pensions runs in the tens of billions of dollars annually and includes story after story of outrageous sums of monies paid out to even young retirees, many of whom are double-dipping with outside salaries after their well-paid government service.

The power of the unions can be quite fearsome. Recently, against the wishes ofmany parents,students and teachers, the California Teachers Association (CTA) stubbornlyfoughtto prevent opening up of schools,though studies have repeatedlyshown(and private schools that are open confirm) that young children have low risks of vulnerability to the COVID-19 virus and are unlikely to pass it along to teachers.

Students in small groups at a time are allowed to enter to pick up their school books at Hollywood High School on August 13, 2020 in Hollywood, California. (Photo by Rodin Eckenroth/Getty Images)

The CTA has come to dominate not just the politics of public education in the state, but has sponsored statewide taxincreasesas it asserts its muscle in California politics. The education establishment also pushes a radical ideological agenda, such as thecampaign for a statewide K-12 EthnicStudies Curriculum that has been welldocumentedas concerning to the Jewish community. In Cupertino, third-graders are being forced to deconstruct their racial identities and rank themselves according to their power and privilege. And in San Francisco, the school board is seeking torename44 schools, (out of 125 district schools), including those named after George Washington, Abraham Lincoln, Paul Revere and even Diane Feinstein.

As Californians consider both the power of special interests and the rise of woke politics, all roads seem to lead to the dominance of San Franciscos Democrats instatewide politics.

The nations most populous state includes the fertile Central Valley, the populous Inland Empire, the majestic mountain interior and the vast northern third of the state, but the state has long been dominated economically, politically and culturally, by the two power centers of the San Francisco Bay Area and Southern California (centered in Los Angeles, Orange and San Diego counties).

In 1970, Los Angeles and San Francisco were roughly co-equal in economic output. The Southern California economy featured light manufacturing, including many defense contractors, which supported American efforts in World War II, the Korean and Vietnam Wars and the Cold War. San Francisco was a financial center rapidly developing a strong network of venture capitalists and academic centers. But at the end of the twentieth century, it was the north that began to benefit from the information technology era that created high wage jobs.

Culture was mostly produced, once upon a time, in Hollywood. Founded by Republicans who promoted the American dream (including Louis B. Mayer, who was Chairman of theCalifornia Republican Party), the entertainment industry provided such GOP political leaders as George Murphy, Ronald Reagan, Clint Eastwood, Sonny Bono, and Arnold Schwarzenegger. Since the 1960s, of course, the entertainment industry has moved sharply to the left, counting many studio heads and wealthy movie stars among the major donors to the Democratic party.

Arnold Schwarzenegger is sworn in as the 38th governor of California by California Chief Justice Ronald George (R) as Schwarzeneggers wife, Maria Shriver (C), looks on November 17, 2003 in Sacramento, California. (Photo by Justin Sullivan/Getty Images)

In the twenty-first century, as Silicon Valleys big tech companies, like Google and Facebook, became the wealthiest enterprises in the world, Californias political figures with roots in the Bay Area grew to statewide and even national prominence.Prolific as fundraisers, this class of Bay Area politicians has included:

Although the Biden administration appears tocelebrateCalifornia as amodel for America, many working-class families feel far less than favorable to this elite San Francisco Democratic political machine.

Although the Biden adminis
tration appears tocelebrate California as amodel for America, many working-class families feel far less than favorable to this elite San Francisco Democratic political machine.

The Recall Governor Gavin Newsomeffortbegan in the summer of 2020 as a politicallong shot. As of January 6, 2021,the Secretary of States office had verified some 410,000 signaturesless than one-third of the amount needed to trigger a recall vote. Officials rejected about 15% of the signatures that the campaign had turned in for verification.

However, asteadily growing volunteer signature gathering effort has now developed into a real citizens movement, with some 5,000 peopledeployedevery weekend to gather signatures.Though limited by COVID-19 lockdowns and stay-at-home restrictions, the forgotten men and women of California an ethnically diverse group of parents and workers, homeowners and renters, from big cities and small towns alike are rising up to make California dream again.

The recall effort is now also increasinglysupported by donors and professional signature-gathering firms as it seeks to meet the March 17, 2021deadline forsubmission of signatures.Over 1.3 million signedpetitions have now been submitted, with tens of thousands more arriving daily. 200,000 signatures have been received via a direct mail effort, and over 1,000,000 signatures have now been gathered by volunteers.

Signatures are gathered in one of three ways: individuals can print, sign and mail it into the campaign themselves; the campaign can send out petitions in mailers that voters return to them; or citizens can sign at petition-gathering tables set up at shopping mall parking lots throughout the state.

One must be registered to vote in California to sign the petition, and the recall campaign vets signatures for accuracy and duplicates before sending them off to a third party for yet another screening. Completed signature petitions are then sent to volunteers in each county who take them to county election officials for verification. The counties then report their results to the state.Counties will have until April 29 to verify the signatures, after which the Secretary of States Office has 10 days to determine if there are enough to qualify the recall for the ballot. California Lieutenant Governor Eleni Kounalakis must then call a recall election between 60 and 80 days from the date of certification, meaning likely in July or August.

Governor Newsoms response to the recall may consider several factors.

Although 19states permit recall elections for governors and other state officials,only two state governors have ever been recalled. The first was in North Dakota, which kicked out Gov. Lynn Frazier in 1921. Most recently, Wisconsin Governor Scott Walker fended off a recall attempt in 2012.

The second was in California, where every governor elected since 1966 has been targeted by recall attempts, but only Governor Gray Davis was dismissed, in 2003.

Manycitizens angered at Sacramento have already fled the state and the millions who remain are lopsidedly liberal. Some 75% of registered voters in the state of California are Democrat or decline-to-state.

Voter registration statewide has the GOP at less than 25%, now in third place, behind both registered Democrats and Independents.

The last time a Republican won a statewide U.S. Senate seat in California was in 1988 (Pete Wilson). The current U.S. House delegation from California is 41 Democrats, 11 Republicans.

All current statewide elected constitutional officers are Democrats, and the state legislature in Sacramento features a supermajority in the State Senate (30 of 40 Senators are Democrats) and in the State Assembly (60 of 80 Assemblymembers are Democrats).

Californias statewide political media coverage is rather limited these days, with most television stations and many newspapers barely covering state politics. And there are very few outlets that are not favorably disposed to the Democrats. Some op-eds havedenigratedthe chances of recalland other stories havesmeared the entire recall movement as the handiwork of thefar-right.

But those paying attention topopulist movements from the Tax Revolt to the Tea Party to the Trump rallies on the right to Occupy Wall Street, the massive anti-Trump rallies and the BLM protest movement on the left recognize that disgruntled citizens across traditional party lines are rising up to challenge insiders, elites and what theyconsider to be corrupt swamp creatures.

disgruntled citizens across traditional party lines are rising up to challenge insiders, elites and what theyconsider to be corrupt swamp creatures.

Newsoms best chance to avoid a recall, of course, would be a sharp rebound in the California economy and the mood of the voters.

Perhaps some personal humility might help, too. So far, that hasnt been the approach taken by the California Democratic Party, whose formal, initial response was tocallthe recall effort acoupandtreasonous.

This seems badly out of sync with awidely agitated electorate. Even hard-nosed Democratic strategist Gary South,who advised former Governor Gray Davis when he lost the 2003 recall, said this response to the recall effort was bad messaging.That was a misfire in a lot of ways, South said. Its not a coup. This is a valid process under the California Constitution.

In recent days, some Democrats have finally beenchallengingGovernor Newsoms lack of communication about the health science behind his decision-making.Democrats may also begin to re-think the same assumptions they had about Gray Davis not being recalled in 2003. In that election, Democrats belatedly put forth then Lieutenant Governor Cruz Bustamante as their candidate to succeed Davis should he be recalled. He lost soundly to Arnold Schwarzenegger.

Although there may be no celebrity candidate like the Terminator on the 2021 ballot, several interesting candidates are mulling bids to replace Newsom, including the 2018 GOP gubernatorial candidateJohn Cox,San Diegos recent MayorKevin Faulconerand billionaire tech investorChamath Palihapitiya. Activists are also rumored to be drafting conservative radio talk show host LarryElder, which may excite school choice advocates in minority communities.

Talk about a grassroots revolution: Hell hath no fury like the parents ofsuffering children.

Larry Greenfield is a Fellow of The Claremont Institute for the Study of Statesmanship & Political Philosophy.

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Anatomy of a Growing Recall: The People vs. The Governor of California - Jewish Journal

Katherine Heigl Admits Grey’s Anatomy Exit Could Have Been More Graceful – TooFab

"I know there's a better way to deal with those things than I did."

Katherine Heigl is taking a look back at her exit from "Grey's Anatomy."

In an interview with People, the actress -- who starred as Dr. Izzie Stevens on the ABC medical drama from 2005 to 2010 -- admitted she could have handled her departure from the show differently.

Katherine Heigl Felt She'd 'Rather Be Dead' After Being Labeled 'Difficult' in Hollywood View Story

"I know there's a better way to deal with those things than I did," said Heigl. "I could have handled it with more grace."

However, the "27 Dresses" star said she doesn't regret her decision to leave the show.

"I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time," said Heigl, who moved to Utah with her daughter after she exited the series. "If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive."

"I certainly regret not learning earlier how to manage my anxiety better," she continued. "Living at that heightened level of anxiety ... created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that."

Publicly it seemed to start when she withdrew her name from Emmy consideration a year after winning the award while on "Greys."

"I did not feel that I was given the material this season to warrant an Emmy nomination" she said in a statement at the time.

A year later, she complained about her 17-hour work day at the hit medical drama during an interview on "The Late Show with David Letterman."

T.R. Knight Latest Grey's Anatomy Alum to Make Shocking Return, 12 Years After He Was Killed Off View Story

Despite everything that went down, Heigl said she's ultimately "grateful" for her time on the long-running ABC drama, calling it a "really extraordinary experience."

"[It] taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle," she explained to People. "There will be difficulties and disappointment and miscommunications, but you must learn how to manage those with grace instead of fear."

"When I look back on 'Grey's Anatomy,' so much of it was a really extraordinary experience," she added. "It feels like a dream sometimes, all of us in it together like that. I'm grateful for all of it -- and I'm so grateful that I grew up enough to allow it to teach me something."

When asked if she'd ever consider returning to show -- which has been known to bring back characters -- Heigl told People, "never say never."

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Katherine Heigl Admits Grey's Anatomy Exit Could Have Been More Graceful - TooFab

‘Grey’s Anatomy’: Fans Still Think Nico Is the Worst – ‘He’s Basically a Statue’ – Showbiz Cheat Sheet

When Dr. Nico Kim (played by actor Alex Landi) first appeared on Greys Anatomy in Season 15, the new character made history on the medical TV drama.

Dr. Kims addition back in 2018 expanded the diversity of Greys Anatomy in numerous ways: He was the shows first openly gay male surgeon, he extended the dramas racial diversity, and he was also the shows first orthopedic surgery fellow (Dr. Callie Torres, played by Sara Ramirez, never actually did her fellowship).

However, despite Dr. Kims groundbreaking storyline and plot development, not everyone loves how the surgeon is portrayed onGreys Anatomy, and some fans on social media have choice words about the actor himself.

RELATED: Greys Anatomy: Here Are All the Ways You Can Watch or Stream All 16 Seasons for Free

Greys Anatomy is no stranger to characters expressing their sexuality and embracing their personal identity. But when actor Alex Landi landed the role of Dr. Nico Kim in 2018, the news quickly caught the attention of fans for how historic the decision was.

Greys Anatomy has, of course, had no shortage of prominent LGBT characters over the years, explained TV Line when the news broke, but few of them have been men. Andnone of them have been surgeons.

Dr. Nico Kim appears in the premier of 2018s 15 season, working alongside Dr. Atticus Lincoln (i.e., Link) to help save a woman who had been hit by a car while biking. In that same episode, Dr. Kim hints at his sexuality when he winks at Dr. Levi Schmitt.

RELATED: Greys Anatomy: Have We Seen the Last of Schmitt and Nico?

After the flirtatious wink in the season 15 premiere, Dr. Kim and Dr. Schmitt get to know each other and share their first kiss in an elevator during season 15s sixth episode before becoming a couple.

Dr. Kim and Dr. Schmitts relationship become a significant part of the shows drama as the two navigate working together and integrating their personal and professional lives. Unfortunately, the constant tension proves too much for the two doctors.

In the sixteenth season of Greys Anatomy, the couple ends their relationship. Dr. Schmitt opens up to his then-boyfriend, saying hes tired of always having to ask for what he wants and explaining that he needs someone whos willing to make sacrifices for him. Dr. Kim responds, saying that he hopes Dr. Schmitt can find someone who can do that one day.

RELATED: Greys Anatomy Fans Cant Decide Exactly Why They Dislike This Character

The Nico and Levi break up scene was so badly written and anti-climactic, complained one fan on Twitter. Nico is an [expletive]the constant disrespect he shows Levi, complained another Twitter user.

Years after their breakup, Greys Anatomy audiences still have strong feelings about the Dr. Kim character, and even about Landi as an actor himself. This guy is a terrible actor, writes one Reddit user. Hes basically a statue and I dont get why he is in the show. No range, no emotion. A grapefruit would do a better job!

Numerous other audience members on the social media network piled on in the comments. One person said I literally hate Nico, while another person tried to give Landi the benefit of the doubt. I never really thought about the actor being bad, writers Reddit user Living-Purple-8004. I just thought the character was so bad. But youre not wrong.

Interestingly, Landi was relatively new to acting when he landed the role of Dr. Kim, and he wasnt a big fan of Greys Anatomy before joining the show. The 26-year-old actually didnt grow up envisioning acting let alone acting on one of TVs most popular shows, reports Entertainment Weekly. He wasnt a Greys Anatomy superfan but hes a quick learner.

Landi tells the outlet that he did a lot of research on the characters and their various relationships, but that its hard to catch up when theres been 20-something episodes a season for 14 seasons.

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'Grey's Anatomy': Fans Still Think Nico Is the Worst - 'He's Basically a Statue' - Showbiz Cheat Sheet

Grey’s Anatomy: Katherine Heigl on exit and having "more grace" – digitalspy.com

Grey's Anatomy star Katherine Heigl has opened up about her exit as Dr Izzie Stevens, admitting that she could have handled the departure "with more grace".

Heigl, who recently said a return to Grey's was "not likely", has spoken candidly about the circumstances surrounding her decision to leave the show in 2010, after five years in the role.

"I know there's a better way to deal with those things than I did," she told People. "I could have handled it with more grace."

Related: Grey's Anatomy star Katherine Heigl describes surprise reunion as "an asshole move"

The actress, after lamenting the way the media portrayed her as "difficult" and "ungrateful" following her exit, reassured fans that she has no regrets about leaving the drama. "I did the right thing for me and for my family," she said.

"I don't actually regret leaving Grey's Anatomy... but I do regret the heightened drama I was feeling at that time," Heigl continued.

"If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive."

Randy Holmes / ABCGetty Images

Related: Grey's Anatomy star Katherine Heigl opens up about severe anxiety after leaving the show

Katherine's latest comments come after she responded to calls for her character to return last month. Offering a disappointing update, she said she's "super focused" on her upcoming Netflix series Firefly Lane for the time being.

"I would never say never but it's not likely," she said.

Grey's Anatomy season 17 airs on ABC in the US. It airs on Sky Witness in the UK with selected episodes also available on NOW TV.

Digital Spy's digital magazine is back! Check out issue 6 including an exclusive chat with Ant & Dec plus all past issues with a 1-month free trial, only on Apple News+.

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Grey’s Anatomy: 10 Major Flaws Of The Show That Fans Chose To Ignore – Screen Rant

While there are several things that haven't aged well on the show, fans have also noticed several flaws they overlooked the first time.

Other medical dramas may come and go, but not ABCs Greys Anatomy, arguably the most successful show of its kind in tv history. There's a reason why it has become one of thelongest-running showson TVas the show has an ability to continuously present compelling stories and craft characters fans cant help but fall in love with.

RELATED: 10 Medical Dramas That Are Better Than Grey's Anatomy

Throughout its run, though, the show has also met criticism. And while some of these are relatively minor issues, fans have also discovered that there are major flaws with this medical drama that everyone has let them get away with.

The shows lead star herself, Ellen Pompeo, pointed this out in a recent interview. Specifically, she took issue with Merediths apparent desperation to cling to Derek as evidenced by one of Merediths most dramatic lines.

[...] That, Pick me, choose me, love me [line]; I was like, Why am I begging a man to love me? the actress told Variety. To me, thats not empowering. Behind the scenes, Pompeo also found herself to be earning less than Dempsey. While speaking with The Hollywood Reporter, the actress revealed she tried to ask for more. They wouldn't give it to me.

Sure, it is understandable for tv dramas to raise the stakes and make us hold our breath from time to time. However, one could argue that the show took things too far when it presented the storyline involving Izzie and her patient Denny.

Granted, it was hard not to root for Denny. However, a storyline wherein a medical intern readily goes against medical ethics just comes across as far-fetched. Heigls performance may have been compelling but one cant help but question the competency and reliability of all the doctors on the show.

When fans first meet George, hes a shy and nervous medical intern who freezes up during his first surgical procedure, earning him the nickname 007. At some point, the viewers also come to realize that OMalley has a serious crush on Meredith and that hes always hoped she would feel the same way.

RELATED: Grey's Anatomy: 5 Of George's Sweetest Moments (& 5 Most Heartbreaking)

To some, this storyline may look cute. But considering all of Merediths other romances, it did feel like they were wasting George's character development. Fans always wished that the character could have had more solo storylines so he had time to shine prior to his seriously traumatic death.

Meredith and Derek have a love story that endures throughout several seasons of the show. Fans see them date. They watch them fight. And, eventually, they witness them get married. Their relationship is meant to be a compelling love story. However, in hindsight, many fans believe there are someproblematic tendencies.

For starters, the power relations between Derek and Meredith has been a topic of conversation for a while now, especially since he was her boss and she was an intern. Even Krista Vernoff believes their relationship wouldn't have lasted if their love story unfolded the way it did

In the season 10 episode entitled "Throwing It All Away," Arizona deals with a young patient with a failing liver. However, when she goes to explain the condition, Arizona mistakenly refers to it as the psoriasis of the liver. Psoriasis happens to be a skin condition characterized by bumpy red patches that are covered by white scales. It can appear on ones scalp, knees, lower back and elbows. On the other hand, cirrhosis refers to the scarring of ones liver and loss of liver function. This is, most likely, what Arizona was referring to.

Although her one true love has always been Derek, Meredith has also dated several other men over the years. Following Dereks death, the show faced the tricky situation of introducing a man into her life. For Pompeo, the timing of it all was too soon.

RELATED: Grey's Anatomy: Meredith's 5 Best Pieces Of Advice (& Her 5 Worst)

But the truth is, the ink wasn't even dry on his exit papers before they rushed in a new guy, the actress told The Hollywood Reporter. That new guy came in the form of Nathan Riggs. Their relationship was heartwarming but it was also awkward. They didnt love the storyline, so that ended.

Throughout the shows run, fans have seen a lot of characters hook up at some point and sometimes, these relationships end up taking over most of the storyline. While one understands that relationships are vital to a drama like this,the show does have a tendency to force characters unnecessarily.

For instance, a lot of fans cringed when Addison and Alex Karev hooked up. Granted, the relationship did not last but one wonders why it had to happen in the first place. Wasnt it enough that Addison was already in a tight situation because of Derek and Mark?

April Kepner is a fearless doctor who suffers from one life-threatening allergy, peanuts (see: "Unbreak My Heart"). However, in the season 14 episode entitled "Judgement Day," a whole batch of cookies with cannabis got distributed among various hospital staff.

In the end, several doctors get high, including Arizona, Avery, Maggie, Alex, Bailey and yes, April. Interestingly, Aprils world gets a little trippy, along with the rest of the affected staff. If she was allergic to peanuts though, her reaction to the cookie would be worse since they are made with peanut butter.

Over the years, fans have seen Merediths dedication to the job. She would do just about anything to save a patient. And when she encounters a young girl with cancer, her heart simply breaks, especially after learning that her immigrant father didnt have proper healthcare to support her treatment.

And so, Meredith decides to commit insurance fraud by claiming that it was her daughter that underwent the procedure instead, allowing the girls treatment to be covered. Some may see this course of action as heroic but there could have been other way to help a critical patient without jeopardizing her career.

Since, the show started, Meredith has been involved in more life-threatening incidents than anyone can count. She ended up holding a bomb inside a patients stomach to keep it from detonating. She nearly drowns after falling into the pier, she's involved in a hospital shooting and she also ends up in a plane crash. It seems that Meredith has been thrown into harms way too much and its about time that it stops.

NEXT: Grey's Anatomy: The First & Last Line For Each Character Who Has Left The Show

Next Legends Of Tomorrow: Sara's 5 Best Story Arcs (& 5 Worst)

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Grey's Anatomy: 10 Major Flaws Of The Show That Fans Chose To Ignore - Screen Rant

Is Grey’s Anatomy new tonight on ABC? Season 17 promo… – CarterMatt

IsGreys Anatomynew tonight on ABC? For those of you interested in getting an answer to that and a further look ahead, weve got that within!

Want some moreGreys Anatomyvideo updates now?Then check out some of the latest on the midseason finale below! Once you do that, subscribeto Matt & Jess on YouTube and view our playlist. Thats our source for all of our coverage.

Lets start things off at the moment by getting down to the cold, hard facts: There is no new episode tonight on the network. If you havent heard, the return of season 17 was pushed back until we get to March 11, and we feel like well have more news to share over the next few weeks on the subject.

So what can you expect to see within a new promo for thats next? We think this is an interesting thing to ponder over right now, given what happened with Meredith at the end of the first part of the season. We saw Ellen Pompeos character end up on a ventilator recently, and that is something that we figure to be a big part of the shows return. Any promo for what lies ahead should very well include some footage of her on the beach, potentially talking with either some current or former series regulars.

Beyond just that, were sure that a promo for what lies ahead will emphasize what is going on now with Teddy and Owen, which makes a certain degree of sense given the tumultuous state of their relationship at the moment. Meanwhile, whats going on with Maggie and Winston next? Theres been a TON of passion there, but we cant just sit back and forget that they really dont know each other all that well. Their relationship is still new and more problems could surface.

Related Check back for some more news on Greys Anatomy, including more details on the future

Are you bummed that the show isnt on the air tonight? Be sure to share right now in the comments! Once you do that, be sure to stick around for more updates. (Photo: ABC.)

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Is Grey's Anatomy new tonight on ABC? Season 17 promo... - CarterMatt

Katherine Heigl Says She Could Have Handled Greys Anatomy Exit With More Grace – ETCanada.com

By Corey Atad.3 Feb 2021 2:52 PM

Katherine Heigl has a few regrets.

In a new interview withPeople, the Firefly Lane star addresses her contentious exit from Greys Anatomy in 2010.

I dont think you get through life without any regrets, Heigl tells the magazine, but you can create some purpose from it.

RELATED: Katherine Heigl On Having To Seek Help For Her Anxiety After Unwarranted Criticism

The actresss departure from the show had come after she withdrew her name from contention for an Emmy on the grounds that she did not feel that I was given the material this season to warrant a nomination.

Looking back, Heigl admits, I know theres a better way to deal with those things than I did. I could have handled it with more grace.

That said, the 42-year-old reiterates, I dont actually regret leaving Greys Anatomy I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time. If Id known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive.

RELATED: Katherine Heigl And Sarah Chalke Are Best Friends Forever In New Firefly Lane Trailer

In retrospect, Heigl recognizes that there were better ways to approach her situation on the show.

I certainly regret not learning earlier how to manage my anxiety better, she explains. Living at that heightened level of anxiety created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that.

The last five years has been really about learning how to manage that anxiety and to control my own thoughts, she says. I learned that not managing stress leads to not dealing with negativity or frustration or disappointment in the proper way.

Something else that experience taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle. There will be difficulties and disappointment and miscommunications but you must learn how to manage those with grace instead of fear.

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Katherine Heigl Says She Could Have Handled Greys Anatomy Exit With More Grace - ETCanada.com

LSD Lets The Brain ‘Free Itself’ From Divisions Dictated by Anatomy, Scientists Find – ScienceAlert

Where does the mind 'meet' the brain? While there's no shortage of research into the effects of psychedelics, drugs like LSD still have much to teach us about the way the brain operates and can shine a light on the mysterious interface between consciousness and neural physiology, research suggests.

In a new study investigating the effects of LSD on volunteers, scientists found that the psychedelic enables the brain to function in a way beyond what anatomy usually dictates, by altering states of dynamic integration and segregation in the human brain.

"The psychedelic compound LSD induces a profoundly altered state of consciousness," explains first author and neuroscience researcher Andrea Luppi from the University of Cambridge.

"Combining pharmacological interventions with non-invasive brain imaging techniques such as functional MRI (fMRI) can provide insight into normal and abnormal brain function."

The new research falls within the study of dynamic functional connectivity the theory that brain phenomena demonstrate states of functional connectivity that change over time, much in the same way that our stream of consciousness is dynamic and always flowing.

As this happens, and the human brain processes information, it has to integrate that information into an amalgamated form of understanding but at the same time segregate information as well, keeping distinct sensory streams separate from one another, so that they can be handled by particular neural systems.

This distinction the dynamics of brain integration and segregation is something that gets affected by psychedelic drugs, and with the advent of brain imaging technology, we can observe what happens when our regular functional connectivity gets disrupted.

In the study, a group of 20 healthy volunteers underwent brain scans in two separate sessions, a fortnight apart. In one of the sessions, the participants took a placebo before entering the fMRI scanner, while in the other slot, they were given an active dose of LSD.

In comparing the results from the two sessions, the researchers found that LSD untethers functional connectivity from the constraints of structural connectivity, while simultaneously altering the way that the brain handles the balancing act between integration and segregation of information.

"Our main finding is that the effects of LSD on brain function and subjective experience are not uniform in time," Luppi says.

"In particular, the well-known feeling of 'ego dissolution' induced by LSD correlates with reorganisation of brain networks during a state of high global integration."

In effect, the drug's state of altered consciousness could be seen as an abnormal increase in the functional complexity of the brain with the data showing moments where the brain revealed predominantly segregated patterns of functional connectivity.

In other words, the 'ego dissolution' of a psychedelic trip might be the subjective experience of your brain cranking up its segregation dynamics, decoupling the brain's structure from its functioning meaning your capacity to integrate and amalgamate separate streams of information into a unified whole becomes diminished.

"Thus, LSD appears to induce especially complex patterns of functional connectivity (FC) by inducing additional decoupling of FC from the underlying structural connectome, precisely during those times when structural-functional coupling is already at its lowest," the authors explain in their paper.

"Due to the effects of LSD, the brain is free to explore a variety of functional connectivity patterns that go beyond those dictated by anatomy presumably resulting in the unusual beliefs and experiences reported during the psychedelic state."

The findings are reported in NeuroImage.

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LSD Lets The Brain 'Free Itself' From Divisions Dictated by Anatomy, Scientists Find - ScienceAlert

2021 IPPE: Anatomy of an outbreak a researcher’s take on cases of H2N2 avian influenza from a live bird market – The Poultry Site

Speaking at the 2021 International Poultry Science Forum, researcher Jongseo Mo from the Southeast Poultry Research Lab explained how different poultry species at live bird markets (LBMs) could serve as reservoirs of avian influenza.

His research, which focuses on the fluctuations of bird flu viruses at these markets in the north-eastern United States, found that the viruses quickly adapted to infect different poultry species. He observed that over the course of a year, one bird flu virus, H2N2/Ck/NY/19, became more transmissible due to a single genetic mutation. Infected Guinea fowl and Pekin ducks shed significant amounts of the virus for an extended period increasing the likelihood of new bird flu infections.

Mos results showed that bird flu viruses with this mutation had the ability to adapt to a new species reservoir. The H2N2 virus could exploit the live bird markets and circulate among multiple bird species, amplifying and sustaining the infection. He stressed that animal health authorities should increase disease surveillance in live bird markets. This bird flu outbreak was low-pathogenic and produced no mortalities the next one might not.

Bird flu, like other avian diseases, can be transmitted through direct contact. For most bird flu outbreaks, a sick bird usually shares space with a healthy one and the disease quickly spreads. This is why poultry farmers are encouraged to limit their birds contact with other flocks and implement biosecurity measures.

LBMs are uniquely challenging from a biosecurity and disease management perspective. Though the birds might be caged while they are in the market setting, there is still a high probability of contact between flocks and between species. People who go to the markets will often walk through other areas or accidentally step in bird faeces before entering the market space, introducing new pathogens to the environment. According to Jongseo Mo, the markets serve as a human-made reservoir for avian diseases. They could have serious animal and public health consequences if they arent properly managed.

Mo wanted to examine the pathogenicity, infectivity and transmissibility of two strains of H2N2 bird flu that he isolated from a live market in New York in 2018 and 2019. He specifically wanted to determine if the virus was changing and if it had the ability to adapt to new species chickens, Guinea fowl, and Pekin ducks.

The two isolated viruses, H2N2 Ck/NY/18 and H2N2 Ck/NY/19, were both low-pathogenic and collected from the three different bird species. However, Mo noted that the Ck/NY/19 isolate had NA stalk deletion in its genome. He hypothesised that this deletion would increase the virus transmissibility in poultry and waterfowl since this association had been observed in other studies.

He designed an experiment with three separate inoculation doses with the isolated viruses. He exposed the three bird species to a low, medium and high virus load, and collected samples to see how the virus was shed and transmitted between the bird species.

His results showed that the H2N2 Ck/NY/18 virus could infect all three bird species if they were exposed to high doses. In terms of shedding and transmission, Guinea fowl shed more virus than chickens. Birds exposed to low and medium doses of the virus did not transmit the infection.

However, birds inoculated with the H2N2 Ck/NY/19 virus at medium and high doses showed higher infectivity and shed the virus for a longer period. This meant that the virus could be transmitted to contact birds something that was not observed in birds inoculated with the Ck/NY/18 strain. Mo noted that Guinea fowl shed the most virus, with Pekin ducks and chickens shedding less respectively.

Mos research suggests that the NA stalk deletion seen in the Ck/NY/19 strain allowed the virus to proliferate quickly, making it more infective and transmissible as a result. The deletion also allowed the virus to replicate in two new bird species, ensuring that the virus remained active in its environment.

Going forward, Mo suggests collecting routine cloacal and oropharyngeal samples from birds at LBMs. If researchers can identify the NA stalk deletion in other bird flu viruses, they could take precautionary measures to prevent the spread of disease.

The International Poultry Science Forum ran on 25 and 26 January as part of the virtual IPPE Conference. Click here for more information about the event.

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2021 IPPE: Anatomy of an outbreak a researcher's take on cases of H2N2 avian influenza from a live bird market - The Poultry Site

Why Did Ellen Pompeo Almost Pass On ‘Grey’s Anatomy’? | TheThings – TheThings

During the time when the casting of Greys Anatomy was taking place, the performer wound up having another offer on the table.

Making a career on the small screen is doable, but not after a performer has gone through the mud to even get an opportunity for something decent. Acting is a tough business, but shows likeThe Office andFriends have taken relative unknowns and have turned them into stars. Because of this, most performers out there will do just about anything to secure a spot on an upcoming pilot.

Ellen Pompeo is a massive star these days thanks to starring onGreys Anatomybut had things gone another way, she wouldnt have even appeared on the show in the first place, forever altering the history of television.

Lets look back and see why Ellen Pompeo nearly passed onGreys Anatomy.

At this point in her career, it is almost impossible to imagine Ellen Pompeo playing another character other than Meredith Grey on the small screen, but there was once a point in time when she was doing anything and everything possible to land a role on a television series. During the time when the casting ofGreys Anatomy was taking place, the performer wound up having another offer on the table.

Landing one role is hard enough, but sometimes, a performer will have to confront the difficult decision of choosing between roles. Choose the right role, and youll be working for a decade while rolling in millions. Choose the wrong role, and your show will be quickly off the air and youll be right back to square one. Such is the life for a performer even lucky enough to be in this predicament.

According toCheatSheet, there was once a point in time when the actress was attached to a show calledSecret Service, which would have been drastically different fromGreys Anatomy. When speaking with TV Guide, Pompeo would reveal, I was offered the role of Meredith. I had done a movie for the studio called Moonlight Mile, so the studio was aware of me. Then I met Bob Orci and Alex Kurtzman We sat down and talked about me possibly doing an arc on Alias.

Pompeo would continue, saying, That didnt happen. Bob and Alex wrote a show called Secret Service. I really wanted to do that and the studio really wanted me to do Greys [Anatomy] instead. I wanted to do the Secret Service pilot that didnt go, of course; me and my brilliant choices.

Related:What Happened To Katherine Heigls Acting Career After She Left Greys Anatomy?

Now that she had confronted the decision of choosing between two roles and had picked the wrong one, it is interesting to think what would have happened hadSecret Service actually taken off and who would have ultimately become Meredith Grey. Eventually, after things fell apart from the show she initially wanted to do, Pompeo would meet with Shonda Rhimes and figure out the right move in an instant.

She would tellTV Guide, I read Grey's and I went and met Shonda and I decided to come on and do this. It was just an invitation and I happily accepted."

And just like that, television history was made. Of course, there is simply no way of knowing what a television show will become in the early stages, but clearly, people behind the scenes saw the potential thatGreys Anatomy had. Even though ABC was swinging and missing on plenty of shows during that era, they were sitting on a gold mine withGreys.

Since the show debuted, it has been nothing short of one of the most remarkable achievements on the small screen. It has been on the air since 2005 and it has aired over 300 episodes, which is a feat accomplished by few programs in history. Pompeo has been laughing all the way to the bank ever since.

Related:Will Season 18 Of Greys Anatomy Happen?

DespiteGreys being the success that it is, the longer that it has gone on, the more people have wondered about how much longer the show has on the air.

While the show has done wonders for the performer, Pompeo has acknowledged that she wont be staying on the show forever and will eventually call it a day sooner rather than later, which is totally understandable.

When speaking withEntertainment Tonight, the performer would touch on this subject, saying, But certainly I think to dip out sooner rather than later, at this point, having done what we've done, to leave when the show is still on top, is definitely a goal. I'm not trying to stay on the show forever. No way. The truth is, if I get too aggravated and I'm no longer grateful there, I should not be there."

Related:Katherine Heigl Branded Bitter After She Slams Justin Chambers Exit From Greys

Secret Service was the show that almost robbed the world of theGreysthey know and love, but thankfully, things worked out for the better in the end.

Next:Which Original Greys Anatomy Star Has The Highest Net Worth?

Is Robert Downey Jr.'s Son, Indio Falconer Following In His Dad's Footsteps?

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Why Did Ellen Pompeo Almost Pass On 'Grey's Anatomy'? | TheThings - TheThings

Katherine Heigl Looks Back on Leaving Grey’s Anatomy : ‘I Could Have Handled It with More Grace’ – Yahoo Entertainment

James Marsden Defends 27 Dresses Costar Katherine Heigl as She Reflects on Being Labelled 'Difficult'

PLUS: Katherine Heigl Reveals Mental Toll of Being Labelled 'Difficult' and If She Would Appear on Grey's Anatomy Again

Katherine Heigl isn't looking to rewrite the past.

After three decades in front of the camera, the Firefly Lane star knows she's made some mistakes, but she can find the value in even her worst blunders. "I don't think you get through life without any regrets," she tells PEOPLE in this week's issue. "But you can create some purpose from it."

The actress, 42, began her career as a child model. Teen stardom followed, but it wasn't until the 2005 premiere of Grey's Anatomy that she became a household name. And with that came added stress, fear and scrutiny.

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The year after her 2007 Emmy win for her role as Dr. Izzie Stevens, Heigl withdrew her name from contention for a repeat, saying she "did not feel that I was given the material this season to warrant" a nomination. That incident, compounded with several other comments and complaints Heigl had previously voiced, earned the star the dreaded label of "difficult."

"I know there's a better way to deal with those things than I did," she admits. "I could have handled it with more grace."

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RELATED: Katherine Heigl Opens Up About the 'Powerful' Bond She Has with Her 'Sacred Six' Friend Group

Heigl left Grey's Anatomy in 2010, at the peak of her diminished reputation, and spent some quality time in what was then her new home in Utah with her daughter Naleigh, now 12.

"I don't actually regret leaving Grey's Anatomy I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time," she says. "If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive."

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Heigl continues: "I certainly regret not learning earlier how to manage my anxiety better. Living at that heightened level of anxiety ... created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that."

For more on Katherine Heigl, pick up the latest issue of PEOPLE, on newsstands Friday, or subscribe here.

Since then, she's been doing the work.

"The last five years has been really about learning how to manage that anxiety and to control my own thoughts," she says. "I learned that not managing stress leads to not dealing with negativity or frustration or disappointment in the proper way."

RELATED: James Marsden Defends 27 Dresses Costar Katherine Heigl as She Reflects on Being Labelled 'Difficult'

Scott Garfield/Walt Disney Television Katherine Heigl and Justin Chambers on Grey's Anatomy

But that wasn't all Heigl learned from her years on the hit Shonda Rhimes series.

"Something else that experience taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle," she says. "There will be difficulties and disappointment and miscommunications, but you must learn how to manage those with grace instead of fear."

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Still, Heigl has fond memories of her time at what was then known as Seattle Grace Hospital, and she says she'd "never say never" to returning.

"When I look back on Grey's Anatomy, so much of it was a really extraordinary experience," she says. "It feels like a dream sometimes, all of us in it together like that. I'm grateful for all of it and I'm so grateful that I grew up enough to allow it to teach me something."

Firefly Lane is streaming on Netflix now. Heigl's new thriller, Fear of Rain, is available on-demand beginning Feb. 12.

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Katherine Heigl Looks Back on Leaving Grey's Anatomy : 'I Could Have Handled It with More Grace' - Yahoo Entertainment

Katherine Heigl admits Grey’s Anatomy exit ‘could have been done with more grace’ – Metro.co.uk

Katherine has some regrets about how she left Greys Anatomy (Picture: Getty/NBC)

Katherine Heigl has spoken out about her Greys Anatomy exit and admitted that she could have handled it with more grace.

The actress played Izzie Stevens on the long-running medical drama, but left after six years in 2010 due to issues behind-the-scenes.

Her character ducked out halfway through season six never to return, and Katherine was later labelled difficult and unprofessional as a result of the fallout.

But after a decade away from the show, Katherine has had time to reflect and admits that while shes ultimately glad she quit, she could have handled the situation better.

Speaking to People magazine, she said: I dont actually regret leaving Greys Anatomy.

I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time.

Something else that experience taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle, she added.

There will be difficulties and disappointment and miscommunications, but you must learn how to manage those with grace instead of fear.

The upset behind-the-scenes started when Katherine famously removed her own name from the 2008 Emmys ballot for her performance on the show, stating she hadnt been given the material to warrant the nomination.

Shonda Rhimes, the creator of the show, later said in an interview with Oprah Winfrey: On some level it stung and on some level I was not surprised. When people show you who they are, believe them.

In 2014, Rhimes took another swipe while promoting new series Scandal, and told Hollywood Reporter: There are no Heigls in this situation, adding that there was a no a**hole policy on set.

Thankfully they now all seem to have buried the hatchet, and in 2019, Greys gave an update on Izzie, revealing she was living on a horse farm in Kansas.

While she never appeared on screen, her love interest Alex Karev (Justin Chambers) left the Seattle hospital in order to win her back, after discovering she had secretly mothered his twins.

Katherine is now leading the cast of new Netflix series, Firefly Lane, alongside Scrubs star Sarah Chalke.

Greys Anatomy is available on Amazon Prime Video in the UK.

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MORE : Will there be a second season of Firefly Lane? Netflix dramas cliffhanger ending explained

MORE : Katherine Heigl weighs in on Alex and Izzies Greys Anatomy reunion: Isnt that an a**hole move?

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Katherine Heigl admits Grey's Anatomy exit 'could have been done with more grace' - Metro.co.uk

Katherine Heigl recalls her controversial exit from Grey’s Anatomy – 9TheFIX

Katherine Heigl has reflected on her sudden exit from Grey's Anatomy.

The Firefly Lane actress, 42, admitted her departure could have been handled differently, but life is filled with momentary lapses in judgement.

"I don't think you get through life without any regrets," she told People of her time on the show. "But you can create some purpose from it."

READ MORE: What happened to Katherine Heigl?

In 2008, Katherine Heigl pulled out of the Emmys race for Grey's. At the time, she said she didn't deserve a nomination because the writing for her character wasn't good enough in Season 4.

"I did not feel that I was given the material this season to warrant an Emmy nomination and in an effort to maintain the integrity of the academy organisation, I withdrew my name from contention," she said in an official statement.

Heigl earned the unflattering title of being "difficult", and eventually left her role as Izzie Stevens in 2010.

"I know there's a better way to deal with those things than I did," she told the outlet. "I could have handled it with more grace."

READ MORE: Grey's Anatomy feud explainer: Katherine Heigl and Isaiah Washington

Heigl said that she didn't regret her decision to leave, but she did regret the "heightened drama" that unfolded upon her exit. The actress has subsequently learned how to prioritise self-care.

"If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive," she continued.

"I certainly regret not learning earlier how to manage my anxiety better. Living at that heightened level of anxiety ... created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that."

Heigl recently shared her thoughts on Grey's storyline where her character reunited with Alex Karev (Justin Chambers).

"Wasn't he with someone?" Heigl told Entertainment Tonight on January 27, referencing Alex's wife Jo (Camilla Luddington). "Listen, isn't that an a---hole move?"

Celebrity throwback photos: Guess who!

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Katherine Heigl recalls her controversial exit from Grey's Anatomy - 9TheFIX

The anatomy of the perfect counter-attacking goal after Mohamed Salah’s stunner – Telegraph.co.uk

There is something about the devastating synchronicity of a well executed counter-attack that pulls you to the edge of your seat, even in these strange times when an abundance of live football can make the action grey and indistinguishable. Mohamed Salah's second goal for Liverpool at West Ham was one such moment.

Why does this category of goal resonate and delight to such an extent? Firstly, counter-attacks are an exhibition of the razor-thin margins that decide top-level football matches: a team can be camped in the opposition's penalty area before picking the ball out of their net less than 10 seconds later. What better encapsulation of the emotional swings a fan experiences throughout the 90 minutes?

They are also very difficult to pull off, demanding technical accuracy at pace which is the most sought-after combination in football. Players who can see a pass or produce a piece of skill at walking pace are two-a-penny, as are those with speed but the touch and awareness of a rhinoceros. What separates the great from theaverage is the ability to do both. Wayne Rooney and Cristiano Ronaldo were sensational exponents of this type of football at Manchester United, as were Arsene Wenger's title-winning Arsenal teams who galloped from one end of the pitch to the other like a cavalry charge. Jose Mourinho's best sides at Chelsea and Real Madrid were also famed for slicing through teams with fast breaks. Leicester's 2015-16 champions spearheaded by Jamie Vardy are also a must mention.

Like passing the baton in a relay race, one mistake and the entire sequence breaks down. How often do you see a team butcher a move when they have four-on-two against the defending team? It is not easy as it looks, yet the picture-book goals that result from a well coordinated counter look delightfully simple.

When analysed in its entirety, a 90-minute football match is really a story of mistake after mistake. Often, especially in an erawith so much focus on pressing, the victorious team is the one who makes the fewest. The best counter-attacks on the other hand, are harmonious vignettes of mistake-free football bordering on perfection. That is what makes them, and Salah's goal, so satisfying. Here we pick out some of the essential components.

"Speed is often confused with insight. When I start running earlier than the others, I appear faster," said Johan Cruyff.

Salah is fast by any measure, but the way he sensed what could develop was crucial. As soon as the ball popped out of the penalty area, Salah is sprinting into space before any West Ham players have broken into a jog. You would expect Salah to win the race starting level, but that moment of 'insight' to start sprinting before anyone else has seen the possibilities is what puts clear blue water between the Liverpool forward and West Ham's retreating players.

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The anatomy of the perfect counter-attacking goal after Mohamed Salah's stunner - Telegraph.co.uk

‘Grey’s Anatomy’ Alum and ‘Private Practice’ Star Kate Walsh Didn’t Inspire ‘The Sweetest Thing’ – Showbiz Cheat Sheet

Actor Kate Walsh, or Addison to fans of Greys Anatomy and Private Practice, isnt the inspiration for The Sweetest Thing. A remark she made on the movies DVD extras led people to believe her adventures with screenwriter Nancy Pimental inspired it. But thats not true.

A few years after playing the title character in Theres Something About Mary, Cameron Diaz signed on for The Sweetest Thing. The 2002 film follows her character, Christina Walters, as she meets a guy named Peter (Thomas Jane) who could be the one. She sets about tracking him down.

Soon she finds herself on a road trip with her best friend Courtney (Christina Applegate) to what they believe is the wedding of Peters brother, Roger (Jason Bateman).Finding Christinas potential soulmate isnt the only thing she and Courtney are doing. At the time they are on their road trip, theyre trying to encourage their friend Jane (Selma Blair) to start dating again after a breakup.

The Sweetest Thing opened to less than stellar reviews. But in the years since its developed cult status. Its considered by some to be the precursor to women-focused films such as Bridesmaids and Bad Moms.

RELATED: Former Greys Anatomy Star Kate Walsh Reunites With a Private Practice Co-Star What Is the Cast up to in 2020?

Pimental told Entertainment Weekly in 2018 how it came to be general knowledge that her friendship with Walsh served a the inspiration for The Sweetest Thing.

A camera crew came to her house to film a feature for the DVD. She chose a very tongue-in-cheek and ironic video about a day in the life of a bigshot screenwriter. Pimental called all of her actor friends over to help, including Walsh.

Kate had said in this thing that we were best friends and the movie was based on our friendship, Pimental said, noting they improvised everything.

Its so funny how people just said, Oh, well the part that Kate said must be true, she added. Now she and Walsh just laugh about it.

RELATED: Greys Anatomy Alum Kate Walsh Makes Iconic Tribute to Meredith and Dereks Reunion

Pimental set the record straight on the true inspiration. Before she wrote the movie shed been working at a restaurant with a tight-knit group of women.

We just ran in this pack where we were these waitresses, and there was always these write-ups about us in magazines, because the place was really popular and a lot of Saudi princes would go there, she said.

Pimental continued, saying they were owning their womanhood.

There was this group of girls and we were running around town and partying at these different clubs and just owning our womanhood, I guess, she said.

And thats where the inspiration for The Sweetest Thing came in.

I just thought, God, theres not an example of this sort of girl posse where were more like guys. Yeah, we decide if we want to give you a fake number or not kind of thing. There wasnt this empowerment, I guess, or this example of it, she said before adding, Thats really how it started.

Watch The Sweetest Thing on Hulu with a premium subscription or rent it on Amazon Prime.

RELATED:Patrick Dempsey Was Convinced Shonda Rhimes Didnt Want Him to Play Derek Shepherd When He Auditioned for Greys Anatomy

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'Grey's Anatomy' Alum and 'Private Practice' Star Kate Walsh Didn't Inspire 'The Sweetest Thing' - Showbiz Cheat Sheet

Long-Term Immunotherapy Linked to Reduced Relapse in Relapsing-Remitting MS – Neurology Advisor

Long-term disease modifying therapies for patients with multiple sclerosis (MS) were effective at reducing relapse and disability accumulation, according to study results published in Neurology.

The predominant goal of MS treatments is the prevention of long-term disability accrual. Study researchers sought to determine whether immunotherapy could prevent long-term disability in patients with relapsing-remitting MS.

In this observational cohort study, researchers assessed patients (N=14,717) with MS who were eligible for class IV immunotherapy. They collected patient data from the MSBase registry.

71% of patients were women (mean age, 36 years; mean age at disease onset, 309 years) and had a median of 6 (interquartile range [IQR], 3.1-10) years of prospective follow-up data. Patients had a median of 4 (IQR, 2-6) relapses, and 69% were exposed to immunotherapies. A total of 1085 patients had at least 15 years of follow-up data (median years of prospective follow-up, 17 years; 95% CI, 15.6-18.8).

Patients who received continuous treatment were less likely to have a relapse event compared with those who were not continuously treated (annual relapse rate, 0.32 vs 0.46, respectively; hazard ratio [HR], 0.60; 95% CI, 0.43-0.82; P =.0016) and less likely to have a 12-month confirmed disability accumulation event (disability accumulation, 0.9 vs 1.5 events, respectively, at 15 years; HR, 0.56; 95% CI, 0.38-0.82; P =.0026).

Compared to untreated patients, fewer patients with continuous treatment reached an Expanded Disability Status Scale (EDSS) step 6 at 15 years (41% vs 13%, respectively; HR, 0.33; 95% CI, 0.19-0.59; P =.00019).

Study researchers did not observe significant difference in disability improvement between the treated and untreated patients (HR, 1.20; 95% CI, 0.96-1.50; P =.1). They also observed similar patterns, stratified by disease duration and age, between these two cohorts.

Limitations of this study include its observational design, the inability to assess delayed treatment effects, and the inability to generalize findings beyond patients with MS followed in academic centers.

These data indicated patients receiving long-term immunotherapy were at decreased risk for disease relapse and neurologic disability escalation. The study authors concluded that sustained, long-term immunotherapy from early stages of MS is advisable as a strategy to preserve patients neurological capacity over the long-term.

Disclosure: Multiple authors declared affiliations with the pharmaceutical industry. Please refer to the original article for a full list of disclosures.

Reference

Kalincik T, Diouf I, Sharmin S, et al. Effect of Disease Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years. Neurology. Published online December 28, 2020. doi:10.1212/WNL.0000000000011242

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Long-Term Immunotherapy Linked to Reduced Relapse in Relapsing-Remitting MS - Neurology Advisor