How rejecting Inter and Lyon set Andre-Pierre Gignac on his way to Tigres immortality – Squawka

In the summer of 2015, Pierre-Andre Gignac was a man in high demand.

The clinical striker was coming fresh off a 2014/15 campaign in which he had scored 21 goals in 38 Ligue 1 appearances for Marseille, with only Alexandre Lacazette (27) outscoring Gignac as he fired Les Phoceens to fourth in the table.

That campaign was the culmination of an upward trend in the strikers career. After managing league goal totals of just eight and one (ouch) in his first two seasons with Marseille, Gignac netted 13 and 16 times across the 2012/13 and 2013/14 campaigns, respectively, setting himself up for a stellar 2014/15.

Gignac had also fought his way back into international contention with France but, despite being such hot property at the time, player and club could not agree on a new contract, and the former Toulouse striker made clear his intention to leave Marseille, then managed by Marcelo Bielsa, as early as December 2014.

I think I will leave at the end of the season, he said. I want to know if (coach Marcelo) Bielsa will stay, but I want a big challenge. I will consider all proposals carefully.

Gignac name-dropped Inter Milan as a potential destination, while the likes of Lyon, West Ham, Newcastle United, West Brom and Dynamo Moscow were all linked with him at one time or another. With that in mind, the decision to join Mexican giants Tigres UANLin June 2015 was one which caught most in Europe off-guard.

Despite hosting the most successful sides in CONCACAF, including the likes of Club America, Chivas and Monterrey, aside from Tigres, Liga MX has never quite had the same appeal or attracted the same level of wider curiosity as its neighbour in the north, Major League Soccer. As such, given the level of interest surrounding Gignac, then only 29 years old, there were those who accused the 36-time France international of making the move for financial reasons Gignac joined Tigres on an initial deal worth $4m per season, making him the highest-paid player in Mexico.

In the six seasons since he crossed the Atlantic, its safe to say Gignac has been on a one-man mission to prove his doubters wrong.

To date, the now-35-year-old Gignac has scored no fewer than 147 goals in 246 appearances across all competitions for Tigres, establishing himself as the clubs record goalscorer and proving the catalyst for an unprecedented era of success in San Nicolas de los Garza. Since his arrival, Tigres have won four league titles (3x Apertura, 1x Clausura), three Campeon de Campeones crowns, the 2018 Campeones Cup and, most recently, the 2020 CONCACAF Champions League the clubs long-awaited first triumph in that competition after final defeats in 2016, 2017 and 2019.

Gignac was the Golden Boot winner during the 2020 CONCACAF Champions League with six goals, while he scored the winner in the 2-1 final win over LAFC. The fact he has scored in three of the tournaments finals only serves to further illustrate the sheer impact hes had on the Mexican game. In short, Gignac is a legend.

For Tigres fans, Gignac is a massively popular figure, Cesar Hernandez of the Mexican Soccer Show podcast told Squawka when asked of the players influence on the Tigres fanbase.

In a roster filled with highly talented players that could easily make up the core of a potential Liga MX all-star team, Gignac has constantly found a way to stand out. Tigres fans absolutely love him for not only consistently scoring and bringing titles, but for also embracing his new Mexican lifestyle.

He quickly picked up Spanish, became a Mexican citizen, and has proudly boasted about his kids growing up in the region. Speaking of kids, a 2019 report from MedioTiempo claimed that over 40 kids from Nuevo Leon have a registered name that is inspired by Gignac. Safe to say fans love him, and hes reciprocated that love back. Hes brought titles, hes already had a Tigres-inspired tattoo, and seems to be genuinely happy in his new home country.

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On where Gignac lands in the conversation of Liga MXs greatest-ever players, Hernandez adds: Weve seen plenty of arguments regarding whether hes the greatest player from outside the country, the greatest striker, or simply just the greatest. I think its far too early to say that hes the definite greatest in Liga MX, but hes undoubtedly in the running.

Hes definitely brought more attention from abroad, especially when you consider that he was born in France and that he could still be playing for an elite European team. That said, the league has plenty of room for growth and needs more players of his calibre to continue propelling it forward.

From Lionel Messi to Diego Maradona, the true icons of football never know when theyre done and there are always higher mountains to scale for those willing to go the distance. In his particular corner of the footballing world, Gignac is on the cusp of doing just that.

Once again, it was he who was the hero as Tigres came from behind to beat Ulsan Hyundai 2-1 in the second round of the delayed 2020 Club World Cup, scoring a first-half brace to send the South Korean side packing. That set up a semi-final glamour tie with Brazilian side and Copa Libertadores champions Palmeiras in an attractive game, but one most expected Tigres to ultimately lose.

As always, Gignac had other ideas. A wonderful Tigres performance saw the Mexican side enjoy 51% of possession and outshoot their Brazilian counterparts 8-7, while a mammoth defensive effort comprising of 16 tackles, 17 interceptions and 19 clearances kept the Libertadores holders at bay. But, of course, it was Gignac who had the final say.

With the game poised at 0-0, Tigres were awarded a penalty as Carlos Gonzalez was dragged down in the box. After already being denied by goalkeeper Weverton on a number of occasions, Gignac calmly stepped up and drilled the ball into the bottom corner, just beyond the reach of the Brazilians outstretched arms. Tigres held out to become the first-ever CONCACAF team to reach the Club World Cup final. The reward? A mouth-watering clash with European and German champions Bayern Munich, Robert Lewandowksi, Joshua Kimmich et al.

We finally achieved an international title, tournament MVP Gignac said after the CONCACAF Champions League final.

I always wanted to win it even though some say it is not worth much. It is worth going to a Club World Cup, and it is worth playing against the best teams from each continent. Today it is Tigres turn.

Following the win over Ulsan, he proclaimed: We know were capable of making history and want to do so.

If the veteran striker can inspire Tigres to an unlikely, iconic victory over Bayern Munich, then Ricardo Ferrettis side will becomethe first-ever CONCACAF team to win the tournament, and he will transcend legendary status, sealing immortality.

Today is Tigres turn. Today is Gignacs turn.

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How rejecting Inter and Lyon set Andre-Pierre Gignac on his way to Tigres immortality - Squawka

Will Blizzard Discuss Diablo Immortal At The Upcoming BlizzConline? – Happy Gamer

For several years now, players have been wondering where the most infamous game in the Diablo franchise is, or when were going to see it. Even as we write this, theres been no word on a release from the game originally announced four years ago.

Most Blizzard fans or those in the gaming world in general likely remember the infamous announcement of Diablo Immortal back in 2018. The announcement of the mobile game gave birth to the Do you guys not have phones meme, mocking a particular developer that remarked condescendingly to an unhappy audience.

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Since then, most players chose to simply forget that the game existed, as many are unhappy that the title is even being developed. Exclusive for mobile devices and smartphones, the title has many worried that the franchise will be slipping towards microtransactions and the like.

Integrity of the franchise aside, the title is still being made regardless of fan preference, and while we wait for Diablo IV to finish its own lengthy development theres not much else to look towards except for the release of the mobile title.

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Theres only one issue when the heck are we going to see this game? Announced three years ago, theres still no sort of release date, only being given a placeholder date of Coming Soon on its official listing.

News of this sort is often shared during BlizzCon, which many are aware was canceled from its usual November slot for 2020 as a result of the ongoing COVID-19 pandemic, forcing the convention to be moved online and to the new BlizzConline format.

This new online format of the convention will be taking place in a week, from February 19th to February 20th. During this time, Blizzard will be discussing all of their main titles, Diablo very much included.

Its likely that this will be the time that we hear any upcoming news about Diablo Immortal so that we know when or if we should be expecting the game. The first segment for the franchise is a Whats Next segment, which is likely to be when the news is announced.

That said, theyve likely been hesitant to give any sort of a release date or update due to the COVID-19 pandemic, which has disrupted a great amount of the companys functions. Given that World of Warcraft: Shadowlands was announced and then delayed, with the announcement of the release coming barely a month from that date, they could simply be waiting until they know a definite date.

RELATED: The Last Of Us Part 2 Coming To PC Seems Like A No-Brainer; And It Probably Is Eventually

If there isnt any news of Diablo Immortal at this BlizzConline, many fans may begin writing the title off completely. Given that the title was unpopular at announcement, many have stopped paying attention to the release altogether.

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Will Blizzard Discuss Diablo Immortal At The Upcoming BlizzConline? - Happy Gamer

Revisiting 8: Federico Fellinis immortal homage to the constructed image – Far Out Magazine

Even if I set out to make a film about a fillet of sole, it would be about me. Federico Fellini

In his retrospective essay on Fellinis 1963 masterpiece, Roger Ebert made the bold claim that 8is the best film ever made about filmmaking. Almost 60 years later,8still maintains its incomparable hold over metafictional investigations that have succeeded it. While other directors like Charlie Kaufman and Woody Allen have tried to emulate Fellinis vision in their own works (notably inSynecdoche, New YorkandStardust Memories), Fellinis seminal effort is the definitive film of the genre and has influenced countless artists as well as scholars. Is8a tiring manifestation of Fellinis penchant for self-indulgence or does the dreamy collection of ideas and images deserve its rightful place among the all-time greats?

AlthoughLa Dolce Vitais his most well-known film,8is undoubtedly Fellinis coveted magnum opus. It is a dizzying experiment with the atoms of cinema; images. Images that threaten to annihilate all logic and reason, consuming the viewer within the totality of their astonishing beauty. Fellini does not waste time in getting to his grand thesis and begins bombarding the audience with these images from the opening sequence itself, which is arguably the most memorable opening scene of all time. He masterfully sums up the anxieties of modernity and masculinity within seconds, depicting a dystopian world where traffic does not move, and people hang their unmoving hands out of buses in which they are packed like sardines.

What most filmmakers spend hours perfecting, Fellini achieves instantly, raising important questions about individual liberty, artistic control and spirituality through the tyranny of gravity. We feel like we have entered Fellinis dreams and we fail to shake off this feeling over the course of the film, unable to distinguish between the realism of the narrative and the surrealism of the subtext.8is probably one of the greatest examples which supports oneiric film theory, a school of thought that compares the act of viewing a film to dreaming. Fellini manages to effortlessly translate the absurdity of dreams to the cinematic medium: curating a unique experience which transcends the limitations of the screen and the banality of life.

The infinitely charismatic Marcello Mastroianni plays Guido, a confused filmmaker who does not know how to proceed with the production of his epic science-fiction film. He is not a sympathetic character, almost a semi-autobiographical vehicle for Fellinis self-loathing, and frustrates the audience as well as his team members with his constant indecision. Guido is trapped in a failing marriage, a loveless affair, a stalled project and recurring dreams of erotic desires. Memories of an idyllic childhood turn into Oedipal nightmares involving problematic notions of women and fear of patriarchal and institutional authority.

As if participating in a rebellion against the conservative regulation of his libido as a young man, Guido does not know how to connect with women anymore without reducing them to sexual objects that adorn his perverse harem. While Francis Ford Coppola chose to present the Vietnam War to the rousing sound of WagnersRide of the Valkyries, Fellini incorporates it in the soundtrack when Guido drinks mineral water and dreams of whipping women who do not submit to him. In doing so, he paints the portrait of an artist who cannot escape his own head. As the days progress, Guidos sci-fi project becomes increasingly personal, and he somehow manages to make it about his marital conflicts rather than the philosophically ambitious themes of religion, outer space and technology. Unimpressed by his efforts, his writer tells him:

Were smothered by words, images and sounds that have no right to exist, that come from the void and return to the void. Of any artist truly deserving of the name, we should ask nothing but this act of faith: to learn silence.

Many have criticised Fellini for his self-indulgent dream sequence and his endless meta-commentary about how he has nothing to say. He would have us believe that there is no film, whatever we have witnessed so far is nothing but a ruptured string of constructed images that have the sole purpose of lying to us. However, Fellinis genius is that he turns his silence into art. The constant indecision and procrastination of Guido become the site of the primary artistic conflict that was lacking in Guidos film. Even though they tear apart the enormous set they were building for the spaceship that he was going to use, it is irrelevant. That was just a skeleton of a dream, the production sit being the graveyard of artistic endeavours. At a hectic press conference where pesky journalists keep aiming questions ranging from celebrity gossip to political baits at Guido, he hides under the table and shoots himself in the head. Was this a part of Guidos fantasy as well, or was it the suicide of the artist who could not live with himself anymore? Fellini refuses to give us any clear answers. Instead, he follows it up with what has become one of the most iconic ending sequences in film history due to its enigmatic symbolism and elusiveness.

On the fresh grave of his potential masterpiece, he orchestrates his own carnivalesque funeral. Maybe it is the concoction of Guidos overactive synapses that are protesting against the bullet he just shot into his skull. He imagines a moment suspended in space-time where he is forgiven for his trespasses, acknowledged for his talents and loved for who he is. Crowning himself with the metaphorical directors hat, he choreographs the rituals of his own death and makes everyone dance on the extension of his own corpse. The fleeting images and bittersweet music slip back into the void, paving the way for an eternal silence.

Originally posted here:
Revisiting 8: Federico Fellinis immortal homage to the constructed image - Far Out Magazine

The lion and the dragon welcome in Chinese New Year – The Garden Island

Businesses and individuals welcomed the Year of the Ox, 2021, with the Chinese lion and, new for this year, the Chinese dragon in the face of rules and health and safety guidelines from the COVID-19 pandemic.

We were completely booked within two hours of announcing the event, said Stacie Chiba Miguel, the general manager for The Shops at Kukuiula, which welcomed the taiko performers of Tsunami Taiko and its singular Chinese lion Friday. We could only have 25 cars. The cars could have 10 people in each one, but we could only allow 25 cars.

Additionally, the lions journey was relocated from inside the shopping center to a singular parking area to further reduce the amount of people attending the welcome of the lunar new year. Attendants wielding special buckets were assigned to the lion to collect the lai see, or good-fortune offering, that normally would be fed to the lion for good luck wishes in the coming year.

We dont have the big crowds the lion always attracts, Chiba Miguel said. But at least we did it.

People want to get rid of all that was bad in 2020, said Pua Laa of the Dance Arts Yoga Academy Saturday at Kukui Grove Center, where the shopping center combined its Chinese New Year with Valentines Day festivities.

The Chinese dragon ours is named Ah Lung gets rid of any lingering bad spirit and energies, Pua Laa said. We welcome a new year, The Year of the Ox. Additionally, the dragon invites positive energy into the celebration of the new year.

The lion is a guardian and keeps watch over any bad spirits wanting to enter the realm.

Common between the lion and dragon is the offering for good luck and fortune.

Normally, this is food, Laa said. If there is no offering, traditionally, the young would be stolen.

Led by Laa and the Pearl of Immortality, Ah Lung, accompanied by the Chinese gong played by Darren Dzurilla of Soul Shine Sonic Sanctuary and the loud Gung Hee Fat Choi from Laa, serpentined throughout the shopping center, attracting people who timidly approached as they came to realization of social distancing.

Eventually, the dragon gets the pearl, Laa said. In Chinese belief, the dragon and phoenix are immortal they never die.

Dennis Fujimoto, staff writer and photographer, can be reached at 245-0453 or dfujimoto@thegardenisland.com.

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The lion and the dragon welcome in Chinese New Year - The Garden Island

Biochemistry professor Tansey discovers protein that could melt tumors – The Vanderbilt Hustler

The discovery of MYC-HCF1 interactions may lead to a future tumor-shrinking treatment.

Vanderbilt University Medical Center (VUMC), pictured above, manages more than 2 million patients each year and is one of the largest academic medical centers in the Southeast, according to its website. (Hustler Multimedia/Truman McDaniel)

On Jan. 8, a study published in the journal eLIFE by Vanderbilt professor of biochemistry and cell and developmental biology, Dr. William Tansey, detailed the discovery of a genetic mutation that can be applied to shrink tumors quite quickly.

The protein, called MYC, is used by animals and humans alike for cell division and cell growth, which also allows tumor cells to rapidly expand. Tumors typically form when cells no longer have control of their growth, and MYC often enables cells to grow out of control, creating tumors. When Tansey and colleagues discovered a particular mutation that blocks the interaction between MYC and another protein, Host Cell Factor-1 (HCF1), tumors rapidly shrunk.

The next step, according to Tansey, is to identify certain molecules that are able to bind to HCF1 to prevent it from interacting with MYC.

Now that we know what we have to go after, the question is if we can do this beneficially and safely, Tansey said.

If molecules that bind to HCF1 are able to be identified, clinical trials could begin within the next decade for a potential tumor-melting clinical drug in the distant future, according to Tansey. However, the process is often long, and it may take years before this discovery is manifested into a drug, per Tansey.

If you had a molecule that was able to bind to HCF1 and prevent it from being touched by MYC, then that could form the basis of a future anti-cancer drug, Tansey said.

This discovery is the second time that a cancer-treating drug was discovered at Vanderbilt. In 2015, Vanderbilt professor of biochemistry, pharmacology and chemistry, Stephen Fesik, alongside Tansey, discovered a protein named WDR5 that similarly halts interactions with MYC. WDR5 is expected to be in clinical trials shortly, and is currently supported by the National Cancer Institutes Experimental Therapeutics Program, according to Tansey.

We are looking for something that will treat pre-existing tumors, and it seems as if this discovery could lead down that path, Tansey said.

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Biochemistry professor Tansey discovers protein that could melt tumors - The Vanderbilt Hustler

Biochemical Clues Reveal How Some Corals Resist Bleaching From Climate Change That Is Killing Coral Reefs – SciTechDaily

A comparison of resistant (left) and bleached (right) corals. Credit: Courtesy of Ty Roach (HIMB)

Climate change is bleaching and killing corals, but researchers from Michigan State and the University of Hawaii are investigating how some can stand up to a warming world.

Coral reefs are beautiful and diverse ecosystems that power the economies of many coastal communities. Theyre also facing threats that are driving their decline, including the planets warming waters.

This threat hit extreme levels in 2015, when high temperatures were turning corals white around the globe. Kaneohe Bay in Hawaii was hit hard; nearly half of its corals bleached.

Hidden in the aftermath of this extreme event, however, were biochemical clues as to why some corals bleached while others were resistant, information that could help reefs better weather warming waters in the future. These clues have now been uncovered by researchers at Michigan State University and the University of Hawaii at Manoa.

It was kind of horrifying, said coral biologist Crawford Drury, who witnessed 2015s bleaching event from Florida before joining UH Manoas Hawaii Institute for Marine Biology, or HIMB. Its disheartening to watch, but I try to think of it as an opportunity.

How this disturbing event became an opportunity is now clear thanks to a February 8, 2021, report in Nature Ecology & Evolution that showcases HIMBs stewardship and MSUs biochemical expertise.

Coral samples were analyzed by mass spectrometry to investigate biochemical differences. Credit: Courtesy of Ty Roach (HIMB)

The researchers discovered chemical signatures in the corals biology, or biomarkers, that are present in organisms that were most resistant to the bleaching. This previously hidden insight could help researchers and conservationists better restore and protect reefs around the world.

Usually, we think of biomarkers as signatures of disease, but this could be a signature of health, said MSUs Robert Quinn, an assistant professor in the Department of Biochemistry and Molecular Biology. This could help us restore reefs with the most resistant stock.

Corals are symbiotic communities where coral animal cells build homes for algae that provide them energy and create their colors. When corals bleach, however, the algae are lost and leave behind skeletons that are susceptible to disease and death.

This symbiosis also plays a role in a corals resistance and resilience to bleaching, which HIMB was in a unique position to investigate literally. The institute sits right next to the reef, enabling experiments in real time.

The reef is about 100 feet away, Drury said. I could be there in 30 seconds.

During the 2015 bleaching event, researchers in the Gates Coral Lab at HIMB had tagged individual corals to keep tabs on them. Because most of the corals recovered, the team could follow them over time.

We think about it as a biological library, said Drury, the principal investigator with the Gates Coral Lab. It was set up by researchers in our lab who knew it would be very valuable.

A view of coral reefs near Hawaiis shores, where bleaching was prevalent in 2015. Credit: Photo courtesy of Ty Roach (HIMB)

Following the bleaching, the team compared and contrasted coral samples in the wild, noting how the organisms responded and recovered, making some surprising observations along the way. For example, neighboring corals could behave completely differently in response to high temperatures. One coral could bleach completely while its neighbor maintained a healthy golden hue.

To understand why, Drury and HIMB postdoctoral researcher Ty Roach, the lead author of the study, sent samples to Quinn at MSU. Here, Quinn and his team could thoroughly analyze the biochemicals of corals collected from this biological library using a method called metabolomics.

Im known more for my medical work, said Quinn, who studies the biochemistry of health and disease in humans. But Ive always loved ocean science. My background is in marine microbiology.

If the coral samples are the books in the library, Quinns lab used sophisticated equipment to reveal the biochemical language within. In particular, his team used tools known as mass spectrometers to understand what set resistant corals apart from susceptible ones.

The corals are completely different in their chemistry, but you cant tell until you run the mass spec, Quinn said. These mass specs are some of the most advanced technology on the planet.

Quinns team found that corals that were resistant to bleaching and those that were susceptible hosted two different communities of algae. The distinguishing feature between these algal populations was found in their cells, in compounds known as lipids.

The researchers metabolomic analysis detected two different lipid formulations. Bleaching-resistant corals featured algae that have what are known as saturated lipids. Susceptible corals had more unsaturated lipids.

This is not unlike the difference between oil and margarine, the latter having more saturated fat, making it solid at room temperature, Quinn said.

This discovery poses all sorts of new questions for researchers: How do the corals get these different algae? Is this difference unique to Hawaiian corals or can it be found elsewhere? How can researchers promote the growth and proliferation of resilient corals in a warming world?

Mass specs are such incredible machines and reveal intricate details of the chemistry involved. The biology is really the hard part. Quinn said. Were working on new grants. There are so many avenues to explore.

This initial project was funded by the Paul G. Allen Family Foundation.

This collaboration has been a great opportunity to ask and answer questions, Drury said. Hopefully, were just getting started.

In the meantime, having this chemical information is promising for coral conservation. When conservationists reseed corals to help restore reefs, they can potentially select more resilient specimens.

We can use natural resilience to better understand, support, and manage coral reefs under climate change, Drury said.

Conservation biology has some of the more successful stories in modern scientific history, Quinn said, pointing to the resurgence of elk in Virginia and bald eagles in Michigan. Someday, maybe we can add corals to that list.

Reference: Metabolomic signatures of coral bleaching history by Ty N. F. Roach, Jenna Dilworth, Christian Martin H., A. Daniel Jones, Robert A. Quinn and Crawford Drury, 8 February 2021, Nature Ecology and Evolution.DOI: 10.1038/s41559-020-01388-7

Funding: Paul G. Allen Family Foundation

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Biochemical Clues Reveal How Some Corals Resist Bleaching From Climate Change That Is Killing Coral Reefs - SciTechDaily

Dr. Joseph Angel de Soto named the Editor & Chief of the Journal of Advanced Biochemistry and Research – Martinsburg Journal

GERRARDSTOWN Dr. Joseph Angel de Soto, of Gerrardstown, has been named editor and chief of "The Journal of Advanced Biochemistry and Research."

He is currently the editor of "Virology Research & Reports." Dr. Soto received his doctorate in medicine and a Ph.D. in pharmacology from Howard University. His dissertation was titled, The Treatment of Breast Cancer with Chemo-hormonal Therapy. He also completed doctoral studies in national security and intelligence.

His clinical medical training was at Howard University Hospital and Washington Hospital Center. He then completed his fellowship at the National Institutes of Health in pharmacogenomics and translational oncology, where he was the fellow of the year.

He has published over 150 articles and papers. As a professor, he has been faculty of the year seven times. De Soto also received the ASCO Cancer Researcher of the Year award. According to the publishers of "The Journal of Advanced Biochemistry and Research," he is considered one of the top physician-scientist and pharmacogeneticists in the world.

For more information, visit the Journal of Advanced Biochemistry and Research website: https://snipub.com/journal-of-advanced-biochemistry/editorial-board-journal-of-advanced-biochemistry/.

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Dr. Joseph Angel de Soto named the Editor & Chief of the Journal of Advanced Biochemistry and Research - Martinsburg Journal

Lemurs prove there’s more than one biochemical recipe for monogamous love – UPI News

Feb. 12 (UPI) -- The hormones that encourage monogamy among rodent pairs don't appear to work the same way in the brains of lemurs, according to a new study.

The research, published Friday in the journal Scientific Reports, suggest there are multiple biochemical recipes of monogamous love.

The vast majority of bird species, approximately 90 percent, are monogamous, but lifelong devotion is rare among mammals -- fewer than 5 percent of mammal species practice monogamy.

For decades, scientists have been trying to figure out why some species commit themselves to a single partner and others play the field. The results from a number of rodent studies suggested a pair of hormones were responsible.

Experiments showed the so-called "cuddle chemicals" oxytocin and vasopressin are released in the brains of monogamous rodents during mating. Scientists found the brains of monogamous prairie voles featured more docking sites, or receptors, for oxytocin and vasopressin than their more promiscuous peers.

For the new study, researchers at Duke University wanted to see if cuddle chemicals worked similar magic on lemurs, which spent more than a third of their lives with a single partner.

When they're not caring for their young or looking for food, lemur pairs can often be found side-by-side, cuddling with their tails wrapped around one another.

The team of scientists used autoradiography, an X-ray imaging technique, to study the distribution of docking sites for cuddle chemicals in the brains of 12 lemurs that had died of natural causes.

The survey featured the seven lemur species: monogamous red-bellied and mongoose lemurs, in addition to five promiscuous species from the same genus.

"They're really the only comparable natural experiment to look for biological signatures of monogamy in primates," lead study author Nicholas Grebe, a postdoctoral researcher at Duke, said in a news release.

Scientists found the density and distribution of receptors for oxytocin and vasopressin on lemur brains were distinct from the patterns found on rodent brains.

The findings suggest the cuddle chemicals work differently in the brains of primates than they do in prairie voles and other rodents.

In rodent brains, the differences between monogamous and promiscuous circuitry were apparent. Scientists found no such distinction among lemur brains.

"We don't see evidence of a pair-bond circuit," said Grebe.

In future experiments, researchers are planning to block oxytocin from binding to receptors in the brains of lemurs and watching how mates behave toward one another.

While it's likely oxytocin and vasopressin still play a role in regulating the romantic decisions of lemurs and other primates, the latest research suggests monogamy in lemurs -- and probably humans, too -- is the product of a unique combination of different brain chemicals and ecological factors.

"There are probably a number of different ways through which monogamy is instantiated within the brain, and it depends on what animals we're looking at," Grebe said. "There's more going on than we originally thought."

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Lemurs prove there's more than one biochemical recipe for monogamous love - UPI News

Global Itaconic Acid Market Rising Trends, Latest Technologies Research And Future Scope 2027 | Itaconix Corporation, Qingdao Kehai Biochemistry Co.,…

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The study conducts SWOT analysis to assess the strengths and weaknesses of the key players engaged in the Itaconic Acid market. Moreover, the report undertakes an elaborate examination of drivers and constraints operating in the market. The report also evaluated the trends observed in the parent market, along with the macro-economic indicators, prevailing factors, and market appeal according to different segments. The report also predicts the influence of different industry aspects on the Itaconic Acid market segments and regions.

What is the SCOPE of Itaconic Acid Market?

The Global Itaconic Acid Market Analysis is a specialized and in-depth study with a special focus on the global market trend analysis. The report aims to provide an overview of the Itaconic Acid market with detailed market segmentation by deployment model, solution, end user industry, and geography. The global Itaconic Acid market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading Itaconic Acid market players and offers key trends and opportunities in the market.

Effect of COVID-19:

Itaconic Acid Market report investigate the effect of Coronavirus (COVID-19). Since December 2020, the COVID-19 infection spread to practically 180+ nations around the world with the World Health Organization pronouncing it a general wellbeing crisis. The worldwide effects of the Covid infection 2020 (COVID-19) are now beginning to be felt, and will essentially influence the Itaconic Acid market in 2020.

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Itaconic Acid Market: Drivers and Restraints

This report explains the more than a few drivers and controls that experience formed the worldwide market. The detailed evaluation of many market drivers allows readers to get a transparent evaluate of the market, together with the market atmosphere, executive coverage, product innovation, construction and market dangers.

The analysis additionally identifies the inventive alternatives, demanding situations, and demanding situations of the Itaconic Acid market. The framework of the ideas will lend a hand the reader determine and plan methods for the prospective. Our hindrances, demanding situations and market demanding situations additionally lend a hand readers know how the corporate can save you this.

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This phase of the report comprises detailed knowledge available on the market in numerous areas. Every area provides a unique market length as a result of every state has other executive insurance policies and different elements.

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Global Itaconic Acid Market Rising Trends, Latest Technologies Research And Future Scope 2027 | Itaconix Corporation, Qingdao Kehai Biochemistry Co.,...

Non-Lethal Biochemical Weapons Market hits USD2.32 Bn by 2028 with Taser International Manufacturing Company, Combined Systems, The Safariland Group,…

The Non-Lethal Biochemical Weapons Market is expected to exhibit a CAGR of +8% to reach US$2.32 bn by the end of 2028.

Non-Lethal Chemical Weapons. The US military is currently engaged in several research efforts to develop non-lethal chemical and biological weapons. These weapons can be placed into two main categories: incapacitants and anti-material agents.

Bacillus anthracis bacteria, which causes anthrax, is one of the most deadly agents to be used as a biological weapon. It is classified by the US Centres for Disease Control and Prevention (CDC) as a Category A agent, posing a significant risk to national security.

The use of biological weapons is prohibited under customary international humanitarian law, as well as a variety of international treaties. The use of biological agents in armed conflict is a war crime.

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Major Key Players of the Market:

Taser International Manufacturing Company, Combined Systems Inc., The Safariland Group, Condor Non-lethal Technologies, BAE Systems, PLC, Herstal SA, Armament Systems & Procedures Inc, Raytheon Company, Lamperd Less Lethal Inc., Mission Less Lethal Technologies, Pepperball Technologies Inc., Lrad Corporation, Amtec Less Lethal Systems Inc.

Non-Lethal Biochemical Weapons Market Study guarantees you to remain/stay advised higher than your competition. With Structured tables and figures examining the Non-Lethal Biochemical Weapons, the research document provides you a leading product, submarkets, revenue size and forecast to 2028. Comparatively is also classifies emerging as well as leaders in the industry.

This study also covers company profiling, specifications and product picture, sales, market share and contact information of various regional, international and local vendors of Global Non-Lethal Biochemical Weapons Market. The market opposition is frequently developing greater with the rise in scientific innovation and M&A activities in the industry. Additionally, many local and regional vendors are offering specific application products for varied end-users. The new merchant applicants in the market are finding it hard to compete with the international vendors based on reliability, quality and modernism in technology.

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What to Expect from this Report on Non-Lethal Biochemical Weapons Market?

It provides a knowledge regarding Porters Five Forces including substitutes, potential entrants, buyers, industry competitors, and suppliers with genuine information for understanding the global Non-Lethal Biochemical Weapons market. Furthermore, it offers detailed data of vendors including the profile, specifications of product, sales, applications, annual performance in the industry, investments, acquisitions and mergers, market size, revenue, market share, and more.

Conclusions of the Global Non-Lethal Biochemical Weapons Market Professional Survey Report 2021 comprises:- Methodology, Analyst Introduction and Statistics Supply. In the end, the analysis comprises Non-Lethal Biochemical Weapons SWOT analysis, investment partialness investigation, investment include research and development tendency investigation.

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Non-Lethal Biochemical Weapons Market hits USD2.32 Bn by 2028 with Taser International Manufacturing Company, Combined Systems, The Safariland Group,...

ASCO GU 2021: ARTO Trial: A Randomized Phase II Trial Enrolling Oligometastatic CRPC Patients Treated with … – UroToday

(UroToday.com)Androgen receptor-targeted agents represent one of the main treatment options for men with metastatic castrate-resistant prostate cancer (mCRPC). The addition of stereotactic radiation therapy to ablate metastatic foci may improve clinical outcomes in oligometastatic setting. The ARTO trial (NCT03449719) is a randomized phase II trial testing the benefit of upfront stereotactic body radiation therapy on all sites of metastatic disease in oligometastatic-mCRPC patients undergoing first-line therapy with abiraterone acetate. At the 2021 American Society of Clinical Oncology Genitourinary Cancers annual meeting (ASCO GU), Dr. Giulio Francolini and colleagues presented a preliminary analysis, reporting results after six months of follow up, together with an exploratory analysis of androgen receptor splice variants (ARV7/ARFL) PSA and PSMA expression on circulating tumor cells detected in this cohort of patients.

This trial enrolled31 patients with oligometastatic-mCRPC (defined as < 3 non-visceral metastatic lesions) that were randomized to receive first-line abiraterone therapy with or without stereotactic body radiation therapy on all metastatic sites. Baseline blood samples to detect circulating tumor cells and evaluate their ARV7, ARFL, PSA and PSMA expression were taken before the start of treatment with abiraterone acetate. Assessments comprehensive of clinical examination and serum PSA were performed every three months. Toxicity was assessed by the Common Terminology Criteria for Adverse Events toxicity scale (CTCAE v.4.03). The trial design for the ARTO trial is as follows:

There were13 patients enrolled in the treatment arm and 18 in the control arm. Overall, 19 metastatic lesions were treated with stereotactic body radiation therapy in the treatment arm. At 6 months, complete response (defined as a serum PSA level < 0.2 ng/dl) was achieved in 6 patients in the treatment arm versus 4 in the control arm, and biochemical response (defined as a PSA reduction > 50% if compared to baseline) was achieved in 10 patients in the treatment arm versus 8 in the control arm. One patient in the treatment arm died from other causes, and one biochemical progression occurred in the control arm. No adverse events occurred in both arms of treatment.

Circulating tumor cell analysis was available for 10 patients, out of whom 4 were found positive for circulating tumor cells (one and three from the treatment and control arm, respectively). ARV7 and ARFL were expressed in one patient from the control arm, and PSMA was expressed in all circulating tumor cell positive patients; PSA was expressed in two patients from the control and one from the treatment arm.

Dr. Fancolini concluded this talk describing preliminary results of the ARTO trial, with the following summary points:

Presented by:Giulio Francolini, MD, University of Florence, Florence, Italy; Radiotherapy Department, University of Florence, Florence, Italy

Co-Authors:Pietro Garlatti, Mauro Loi, Beatrice Detti, Michele Aquilano, Andrea Allegra, Barbara Guerrieri, Viola Salvestrini, Pamela Pinzani, Chiara Bellini, Francesca Salvianti, Giulia Stocchi, Lucia Pia Ciccone, Giulia Salvatore, Mariangela Sottili, Vanessa Di Cataldo, Isacco Desideri, Monica Mangoni, Icro Meattini, Lorenzo Livi; University of Florence, Florence, Italy; Radiotherapy Department, University of Florence, Florence, Italy; AOU Careggi, Firenze, Italy; Radiotherapy Unit, A.O.U. Careggi, Florence, Italy; University of Florence, Firenze, Italy; Radiotherapy Department, University of Florence, Firenze, Italy; Clinical Biochemistry and Clinical Molecular Biology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; Radiotherapy Department, Universit di Firenze, Firenze, Italy; Radiotherapy Department, Florence, Italy; Department of a Biomedical, Experimental and Clinical Sciences "Mario Serio", Section of Radiation Oncology, University of Florence, Florence, Italy; Cyberknife Center, Istituto Fiorentino di Cura e Assistenza (IFCA), Firenze, Italy; Radiation Oncology Unit-Oncology Department, University of Florence, Florence, Italy

Written by:Zachary Klaassen, MD, MSc Urologic Oncologist, Assistant Professor of Urology, Georgia Cancer Center, Augusta University/Medical College of Georgia,Twitter:@zklaassen_md during the2021 ASCO Genitourinary Cancers Symposium (ASCO GU), February 11th to 13th, 2021

Related Content:The Oligometastatic-Directed Therapy Trend in Prostate Cancer: Are We Being Precocious or Premature?

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Chitosan Market Is Expected To Register A Healthy CAGR Of 14.8% In The Forecast Period Of 2019-2026 | Major Giants Panvo Organics Pvt Ltd, Qingdao…

To achieve maximum return on investment (ROI), its very fundamental to figure out market parameters such as brand awareness, market landscape, possible future issues, industry trends and customer behavior where this winning Chitosan report comes into picture. The report supports in evaluating brand awareness, market landscape, possible future issues, industry trends and customer behavior with which refined business strategies can be fixed. Chitosan Market document analyzes the market status, growth rate, future trends, market drivers, market restraints, key opportunities, challenges, market risks, entry barriers, sales channels, distributors and Porters Five Forces Analysis.

Furthermore, businesses can decide upon the strategies about the product, customer, key player, sales, promotion or marketing by acquiring a detailed analysis of competitive markets. Besides, Chitosan marketing report sorts out the breakdown of global data by manufacturers, region, type and application while analyzing the market status, market share, growth rate, future trends, market drivers, opportunities and challenges, risks and entry barriers, sales channels, and distributors. The report also contains a precise investment analysis which forecasts forthcoming opportunities for the market players in the Chitosan industry. This Chitosan Market research report categorizes the market by companies, geographical region, type, component, application and end-use industry.

Global chitosan market is expected to register a healthy CAGR of 14.8% in the forecast period of 2019-2026. The rise in the market value can be attributed to the growing awareness about health globally, unique properties of chitosan and availability of abundant raw material. The report contains data of the base year 2018 and historic year 2017.

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The report also inspects the financial standing of the leading companies, which includes gross profit, revenue generation, sales volume, sales revenue, manufacturing cost, individual growth rate, and other financial ratios.

The market is predicted to witness significant growth over the forecast period, owing to the growing consumer awareness about the benefits of Chitosan. The increase in disposable income across the key geographies has also impacted the market positively. Moreover, factors like urbanization, high population growth, and a growing middle-class population with higher disposable income are also forecasted to drive market growth.

According to the research report, one of the key challenges that might hinder the market growth is the presence of counter fit products. The market is witnessing the entry of a surging number of alternative products that use inferior ingredients.

Chitosan Market Country Level Analysis:

The countries covered in the Chitosan Market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, Israel, Egypt, South Africa, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

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Leading Chitosan manufacturers/companies operating at both regional and global levels:Panvo Organics Pvt Ltd, Qingdao Yunzhou Biochemistry co., ltd., , Advanced Biopolymers AS, meron, Heppe Medical Chitosan GmbH, Kitozyme, LLC, Kraeber & Co. GmbH, Foodchem International Corporation, FMC Corporation, Golden-Shell Pharmaceutical, Primex EHF, Nano3Bio, KOYO CHEMICAL CO.,LTD., Dainichiseika Color & Chemicals Mfg. Co., Ltd., Biothera Pharmaceuticals among others.

Key points of the report

Reasons for purchasing this Report

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Table Of Contents: Chitosan MarketPart 01: Executive Summary

Part 02: Scope Of The Report

Part 03: Research Methodology

Part 04: Market Landscape

Part 05: Pipeline Analysis

Part 06: Market Sizing

Part 07: Five Forces Analysis

Part 08: Market Segmentation

Part 09: Customer Landscape

Part 10: Regional Landscape

Part 11: Decision Framework

Part 12: Drivers And Challenges

Part 13: Market Trends

Part 14: Vendor Landscape

Part 15: Vendor Analysis

Part 16: Appendix

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Chitosan Market Is Expected To Register A Healthy CAGR Of 14.8% In The Forecast Period Of 2019-2026 | Major Giants Panvo Organics Pvt Ltd, Qingdao...

Biochemical Analyzer Market Report-Development Trends, Threats, Opportunities and Competitive Landscape In 2020 KSU | The Sentinel Newspaper – KSU |…

Biochemical Analyzer Market Research Study provides an all-inclusive assessment of the market while propounding historical intelligence, actionable insights, and industry-validated & statistically upheld market forecast. A verified and suitable set of assumptions and methodology has been leveraged for developing this comprehensive study. Information and analysis of key market segments incorporated in the report have been delivered in weighted chapters.Biochemical Analyzer Marketreport (2021-2026)enhanced on worldwide competition by topmost prime manufacturers which providing information such ascompany profiles, product picture and specification, capacity, production, price, cost, revenueand contact information.

Stakeholder Benefits:

The stakeholders garner immense benefits from this report on the Biochemical Analyzer Market. This report is a blend of expert analysis and extensive research done by the analysts at ResearchMoz. The report offers expansive insights into the Market form all aspects.

The Major Key Players Profiled In This Report Include:

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Biochemical Analyzer Market Segmentation

The report contains the market size with 2020 as the base year and an annual forecast up to 2027 in terms of sales (in million USD). For the forecast period mentioned above, estimates for all segments including type and application have been presented on a regional basis. We implemented a combination of top-down and bottom-up approaches to market size and analyzed key regional markets, dynamics and trends for different applications.

Biochemical Analyzer Market Segment by Type:

Biochemical Analyzer Market Segment by Application:

Accurate Geographical Dimensions

This report explores the different regions and the trends associated with a particular region. The report has all the information required for a perfect geographical information landscape. The prominent regions covered in this report are:

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Biochemical Analyzer Market impact Factors Analysis:

Technology Progress/Risk, Substitutes Threat, Economic/Political Environmental modification.Technology Progressin connected trade,shopper Needs/Customer Preferencemodification.

Some important questions that this report answers are as follows:

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Automatic Veterinary Biochemistry Analyzer Industry 2020 Includes The Major Application Segments And Size In The Global Market To 2027 NeighborWebSJ…

DataIntelo offers a detailed report on Automatic Veterinary Biochemistry Analyzer Market. The report is a comprehensive research study that provides the scope of Automatic Veterinary Biochemistry Analyzer market size, industry growth opportunities and challenges, current market trends, potential players, and expected performance of the market in regions for the forecast period from 2020 to 2027. This report highlights key insights on the market focusing on the possible requirements of the clients and assisting them to make right decision about their business investment plans and strategies.

The Automatic Veterinary Biochemistry Analyzer market report also covers an overview of the segments and sub-segmentations including the product types, applications, companies and regions. This report further includes the impact of COVID-19 on the market and explains dynamics of the market, future business impact, competition landscape of the companies, and the flow of the global supply and consumption. The report provides an in-depth analysis of the overall market structure of Automatic Veterinary Biochemistry Analyzer and assesses the possible changes in the current as well as future competitive scenarios of the Automatic Veterinary Biochemistry Analyzer market.

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The published report consists of a robust research methodology by relying on primary source including interviews of the company executives & representatives and accessing official documents, websites, and press release of the companies. DataIntelo is known for its data accuracy and granular market reports.

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Key companies that are covered in this report:

Biochemical Systems InternationalBPC BioSedCarolina Liquid ChemistriesAbaxis EuropeAMS AllianceRandox LaboratoriesRayto Life and Analytical SciencesScil Animal CareCrony InstrumentsDiaSys Diagnostic SystemsEurolyser DiagnosticaGesan ProductionHeskaIdexx LaboratoriesLITEON IT CorporationShenzhen Icubio Biomedical TechnologyURIT Medical Electronic

*Note: Additional companies can be included on request

The report covers a detailed performance of some of the key players and analysis of major players in the industry, segments, application, and regions. Moreover, the report also considers the governments policies in different regions which illustrates the key opportunities as well as challenges of the market in each region.

By Application:

Pet HospitalVeterinary StationOther

By Type:

Bench-Top Veterinary Biochemistry AnalyzerPortable Veterinary Biochemistry Analyzer

As per the report, the Automatic Veterinary Biochemistry Analyzer market is projected to reach a value of USDXX by the end of 2027 and grow at a CAGR of XX% through the forecast period (2020-2027). The report describes the current market trend of the Automatic Veterinary Biochemistry Analyzer in regions, covering North America, Latin America, Europe, Asia Pacific, and Middle East & Africa by focusing the market performance by the key countries in the respective regions. According to the need of the clients, this report can be customized and available in a separate report for the specific region.

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The following is the TOC of the report:

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Automatic Veterinary Biochemistry Analyzer Market Overview

Automatic Veterinary Biochemistry Analyzer Supply Chain Analysis

Automatic Veterinary Biochemistry Analyzer Pricing Analysis

Global Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast by Type

Global Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast by Application

Global Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast by Sales Channel

Global Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast by Region

North America Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast

Latin America Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast

Europe Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast

Asia Pacific Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast

Middle East & Africa Automatic Veterinary Biochemistry Analyzer Market Analysis and Forecast

Competition Landscape

Why you should buy this report?

This report offers a concise analysis of the Automatic Veterinary Biochemistry Analyzer market for the last 5 years with historical data & more accurate prediction for upcoming 6 years on the basis of statistical information.

This report helps you to understand the market components by offering a cohesive framework of the key players and their competition dynamics as well as strategies.

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Which end-user is likely to play a crucial role in the development of the Automatic Veterinary Biochemistry Analyzer market?

Which regional market is expected to dominate the Automatic Veterinary Biochemistry Analyzer market in 2020-2027?

How is consumer consumption behavior impacting the business operations of market players in the current scenario of the Automatic Veterinary Biochemistry Analyzer market?

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Alumnae Key to Nationwide Work on COVID-19 Vaccine – Kettering University News

Four alumnae specializing in documentation, chemical testing, quality control and software analysis have joined the fight against COVID-19.

The women Aubrie (Hoffman) Eaton, Mia (Jonascu) Hillaker, Debra (Pratt) Piper and Katie (Esch) VandeBerg all work at Par Pharmaceutical in Rochester, Mich., and apply their skills learned while they were students at Kettering University to the production of various sterile injectable products, including a potential vaccine for COVID-19.

Par Sterile began production on NVX-CoV2373, a protein-based COVID-19 vaccine candidate from Novavax, Inc. in September 2020. In December, Novavax announced the initiation of Phase 3 clinical trials in the United States and Mexico, and in January announced highly encouraging efficacy results from trials taking place in the United Kingdom and South Africa.

Its very humbling, said Quality Control Chemist VandeBerg (17, Chemistry). Its nice to know that were part of the effort attempting to make a difference in the fight against COVID and how its being treated.

Its not the front line, but its close to it in light of the fact that we are involved with the production of a potential COVID-19 vaccine, she added. Its very cool to be working on something that may have a big impact in our history.

Science, Safety and Steps to Save Lives

VandeBerg, who has been with the company since October 2017, conducts tests on raw materials before they head to production.

We put a lot of good time and effort into making sure its done the right way every time, VandeBerg said.

Materials then head to Senior Scientist Eaton (14, Biochemistry), who is responsible for chemical testing at various stages of production and completion to ensure the product meets safety standards and performs as it should.

It has been interesting. Its been moving very quickly, Eaton said. The assumption is fast means reckless, and that upsets me. There is a high level of integrity in the scientific field with defined processes and procedures. The FDA doesnt just approve things.

Eaton has been at Par Pharmaceutical since September 2020. She said this work has given her a sense of purpose.

We are by no means on the front lines, but its important to recognize that we, scientists, are very focused on working on solutions to protect those heroes, Eaton said.

Neither Eatons nor VandeBergs jobs could be done without the work of Scientist Debra Piper (13, Biochemistry). She supports the laboratory by implementing the software and analysis systems used with the testing equipment to ensure they are used appropriately and efficiently.

Piper started working at Par as part of Kettering Co-op as a student. There until 2016, she worked elsewhere for four years but returned to Par in the spring of 2020.

Its a great feeling to know your job may actually have an impact on people, and what youre doing is going toward a common cause we all want to support, Piper said. It makes you respect your job more and enjoy your job more.

Documenting Success

However, these jobs cant be done without documentation, and thats where Hillaker (18, Applied Biology) comes in.

Hillaker, who is a Quality Document Associate for a little more than a year, ensures that documents needed for the process are correct so that all standards are met. Some of the documents include labels, testing forms and batch forms, which in the simplest terms, are similar to recipe cards for products.

It feels a little bit surreal, just because I go to work every day and think, Oh my goodness, my signature is going to be on some of these very crucial documents, she said.

Like her co-workers, Hillaker recognized the potential impact her job has on society.

The whole experience overall has been crazy, but wonderful, she said. The hours have been crazy, the workload has been crazy, but at the same time, it could help the greater good in a way that I wasnt expecting.

Piper has been able to do much of her work remotely, while Hillaker, Eaton and VandeBerg have been on site. Schedules were shifted to reduce the number of people in the facility at any one time to meet COVID-19 guidelines.

Kettering Mindset and Co-op Experience Give Valuable Advantage

The women said their time at Kettering University not only connects them, but has armed them with the skills and mindset to be successful in their jobs.

Ketterings slogan was Think Differently, Eaton said. I have found that I ask different sorts of questions because my mind thinks of several possibilities instead of the direct route. I have noticed when I ask questions, people say, Ive never thought about that. Its coming at things from different angles.

VandeBerg, Hillaker and Piper cited their Kettering Co-op experiences as great preparation for life after graduation. Piper said being able to enter the industry at a younger age than your counterparts from other colleges is a valuable advantage.

You can go to school and work at the same time and apply what youre learning while youre working, she said. It really teaches you how to excel in the workforce.

Hillaker said she knew it would be a good fit for her current job because of how much she enjoyed the elements of her Co-op experience as a scribe for the Hurley Medical Center.

I was kind of surprised in the ways that Kettering prepared me, she said. I was more prepared for the medical field, but through my Co-ops and research, I found that I liked the more technical side of it and computer science part. I really enjoyed working with the data and data models and attention to detail that you get with scribing.

Eaton and Piper said they appreciated the smaller classes, too.

A lot of these upper-level classes are very, very difficult, and once you get [to upper level] chemistry, class sizes were six to nine people, Eaton said. You dont have that in other college experiences.

She said the small classes allowed her to work with the entire class to study and prepare, and made her feel as if the professor was part of her team.

Piper echoed Eatons sentiments, noting there were four or five people from her discipline in her graduating class.

I think one of the things I enjoyed the most was when the four or five of us got together to hang out, work on school work and teach each other the lessons, Piper said. We all wanted to succeed together. There wasnt competition for who was going to be the best; we all wanted to be successful together and that was something I was able to do at Kettering. I think at larger schools youre not able to get that.

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Alumnae Key to Nationwide Work on COVID-19 Vaccine - Kettering University News

Scientists discuss inclusion and equity in biomedical research at virtual event – Vanderbilt University News

Biomedical researchers across Vanderbilt University will convene to discuss the history and impact of Black biomedical scientists on Monday, Feb. 15, at noon CT. The virtual discussion, From Inclusion to Equity: The Story of Black Biomedical Scientists, will be moderated by Dr.Andr L. Churchwell, vice chancellor for equity, diversity and inclusion and chief diversity officer.

The event is free and open to the public. Registration is required.

The discussion will cover discoveries and experiences of earlier generations of Black biomedical scientists, the impact of their discoveries, and existing disparities that the academic biomedical community still needs to overcome to reach its full potential.

Panelists areBreann Brown, assistant professor of biochemistry;Ren Robinson, associate professor of chemistry and Dorothy J. Wingfield Phillips Chancellors Faculty Fellow, andSteven Townsend, assistant professor of chemistry and Deans Faculty Fellow in the College of Arts and Science.

Participants will be able to submit questions in advance through the registration page.

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Scientists discuss inclusion and equity in biomedical research at virtual event - Vanderbilt University News

Calves on the Ground Put Money in the Pocket – Drovers Magazine

The next crop of calves is what keeps the cattle industry in business. Knowing this, a Texas A&M University study aims to reduce reproduction failure, which can cause a significant loss to the U.S. beef industry.

Rebecca Poole, Ph.D., a postdoctoral research associate in theCollege of Agriculture and Life SciencesDepartment of Animal Science, has received a two-year grant from theU.S. Department of AgricultureNational Institute of Food and Agriculture.

Pooles project, Hormonal and Immunological Influences on the Uterine Microbiome in Cattle, is aimed at developing a better understanding of the relationship between reproductive hormones and immune changes as well as the microbiome of the reproductive tract in beef cattle.

Like a fertility clinic for humans its the same idea, just bringing it to the beef cattle world, Poole said. They have found there are a lot of relationships between the microbiome of the reproductive tract and fertility in women, and so the research has continued from there to establish the understanding of microbiomes in other species, like our livestock.

She said now that the technology is available to better understand the microbiome, its a great time to work in this area of research. Microbiome research in the past was dependent on being able to culture certain bacteria in a petri dish, but that was a limiting factor, because only about 1% of the bacteria can be cultured.

Now, using a sequencing-type approach, we are able to determine all the bacteria in a certain environment, Poole said.

Poole said the presence and activity of symbiotic bacteria in the reproductive tract and its effects on fertility is relatively unknown in cattle, and so that is where she will concentrate her research.

She believes that variation in reproductive hormone secretion and/or immune function control the bacterial species diversity in the uterus, which subsequently affects pregnancy establishment and maintenance in beef cattle.

The producer doesnt necessarily need to understand the different types of bacteria, Poole said. My research will take the concepts the producers understand along the lines of the estrous cycle, estrous synchronization protocols, and reproductive hormones; and I will see how those relate to the microbiome so that we can find ways to potentially manipulate it, from a hormonal standpoint, to create a healthy microbiome to establish a pregnancy.

She said she will be using standard estrous synch protocols that producers are used to, such as using GnRH or prostaglandin injections to create a high estrogen or high progesterone environment and seeing how that manipulates the bacterial species.

We have found differences between cattle that are essentially able to establish a pregnancy versus those that do not, differences in their uterine microbiome before breeding, Poole said. So really we are just trying to figure out if there are other mechanisms that are controlling that microbiome, like reproductive hormones, and also the immune system is another component that is most likely involved with changes in the microbiome.

Pooles project further contributes to the Department of Animal Sciences Areas of Excellence pregnancy and developmental programming,which emphasizes an increased understanding of animal reproduction at molecular, cellular and whole animal levels.

The first objective of this project is to look at the relationship between differing levels of reproductive hormones and the reproductive microbiome prior to breeding. The second objective is to look at the relationship between the immune system and reproductive microbiome.

Poole said she will be collecting samples over the next month and will artificially inseminate the cows and then begin looking at pregnancy results. She expects by the end of summer to have results that will help begin establishing the relationship between the reproductive hormones and the reproductive microbiome.Poole holds a blood collection tube post-centrifugation. The tube is coated with sodium heparin for the extraction of plasma (yellow portion) which can be used for hormone detection assays.

This will help us gain a better understanding of what is influencing the reproductive tract microbiome in cattle and help us focus on improving fertility in beef cattle through enhance management practices, she said. The ultimate goal is to increase the sustainability of the animal production industry.

Poole said in addition to this research, she is a part of another project looking at nutritional effects on the microbiome, and that should be available around the same time.

So, our suggestions to producers could be based on nutrition or it could be a hormonal thing, which means we suggest they take a blood sample at a certain point in time to see where a cow stands is she a good contender for breeding based on her hormone concentrations? she said. It may mean, for example, suggesting the use of cattle heat detection patches, which is an indication of estrogen concentrations at breeding.

Poole said knowing this information will allow producers to feel more comfortable at the time of breeding based on information of the cows reproductive hormones, which will indicate what its reproductive microbiome looks like.

Not every producer will utilize this information not those, for example, who just turn the bull out in the pasture and hope for the best, she said. This would be geared toward someone who has an extensive management program of some kind, utilizing estrous synchronization and artificial insemination.

Based on my results, I can provide suggestions for producers and say, you need to take a blood sample at this time, and lets look at her reproductive hormone concentrations or her immune cell levels and see if her uterine microbiome environment is acceptable for breeding, Poole said. Again, it is like the human fertility clinic, and we can estimate likelihood of establishing a pregnancy.

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Calves on the Ground Put Money in the Pocket - Drovers Magazine

US Department of Agriculture Awards UNC Grant to Improve Pregnancy Outcomes in Dairy and Beef Cows – PRNewswire

To summarize: The recently conceived embryo must signal its presence to the mother, and a successful pregnancy can only establish when the signal preserves production of a pro-pregnancy hormone, progesterone, from a gland on the ovary called the corpus luteum. Progesterone from the corpus luteum in turn prompts the uterus to secrete nourishing factors that support the developing pregnancy.

Sometimes, there's a "miscommunication" between the developing embryo and the mother, resulting in the corpus luteum dying, progesterone levels dropping and the loss of the pregnancy.

For female dairy cows, the likelihood of this miscommunication has increased, resulting in fewer pregnancies. It's speculated that slower developing embryos miss their window of opportunity and fail to establish the maternal recognition of pregnancy. Burns and Haughian believe that omega-3 fatty acids could "extend the window" of time for perfectly healthy, yet slow growing, embryos to be recognized, resulting in more successful pregnancies.

"It's been documented that we do see an increase in pregnancy outcomes with the supplementation of omega-3 containing fish byproducts to the diet, and we're really interested in fine-tuning the mechanisms to make it even more efficient," Burns said.

Because the embryo is developing slowly, the mother cow doesn't recognize she's pregnant, so she naturally signals from the uterus to kill the corpus luteum gland, which resets her cycle and inadvertently also kills the embryo. The uterine hormone that ultimately kills the gland and the underdeveloped embryo is prostaglandin. Supplementing omega-3 fatty acids appears to shield the gland from prostaglandin, allowing the embryo more time to develop and be recognized, resulting in more successful pregnancies.

"Because the embryo develops slowly, the mother thinks she's not pregnant and, thus, releases the prostaglandin signal to kill the gland, and once the gland's going, then the embryo's also going [to die]" said Burns. "What we're trying to do is widen this window of opportunity so that if by chance mom makes a mistake and releases the prostaglandin hormone, then we can better protect the gland from the first initial signal with the use of omega-3 fatty acids in order to give the developing embryo more time to signal to its mother that she's still pregnant."

If Burns and Haughian's research proves positive, then dairy farmers and cattle ranchers could see an increase in profits that would then trickle down to consumers as cost-savings when purchasing milk and beef products.

"By increasing pregnancy outcomes, by say, 10%, this translates to an increase of profitability for American ranchers and dairy farmers in the millions of dollars in meat and dairy products," Burns said.

Another benefit is applying this research to other fields of biology. "You often also learn something about the way humans operate, as well," Haughian said. "In some ways, we know more about how we, as humans, reproduce due to work done in cattle, sheep, pigs, etc. There's this ultimate benefit to better understand human reproductive processes."

Burns and Haughian have partnered with Colorado State University's Animal Reproduction and Biotechnology Laboratory to house, care and feed the animals the omega-3 rich fish byproducts for their research. They're also conducting research in their lab at UNC with the help of numerous UNC undergraduate and graduate students.

"This gives an opportunity for undergraduates to participate in authentic research experiences and an opportunity to work with large, domestic farm animals," said Burns. "It allows these students to get into the laboratory and develop hands-on laboratory skills."

The research's first trial is set to begin in March, dependent on public health guidelines due to the ongoing COVID-19 pandemic.

About the GrantProject Title: Influence Of Fish Oil On Corpus Luteum FunctionGrant Awards and Funding Agencies: $500,000 four-year grant from the USDA's National Institute of Food and AgricultureResearchers: Patrick Burns (principal investigator) and James Haughian (co-principal investigator)Student Researchers: Anika Shelrud, Grace Kochman, Winford Rule, Hayley Stauber, Travis Kinn, Kathy Mireles, Aubrey Chacon, Natalia Sheppard, Allison Updike and Cam HuberMore information about the grant

Contact: Katie Corder Public Relations Strategist [emailprotected]

SOURCE University of Northern Colorado

http://www.unco.edu

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US Department of Agriculture Awards UNC Grant to Improve Pregnancy Outcomes in Dairy and Beef Cows - PRNewswire

Small animals that carry disease adapt well to our activities A study suggests that small mammals – Sciworthy

On average, humans cut down 2,400 trees each minute for expanding farmland and neighborhoods. This increases our risk of being exposed to animal-borne diseases, according to a study published in the journal Nature. Researchers found that, compared to untouched land, heavily-modified natural landscapes are breeding grounds for animals that carry disease-causing viruses and bacteria.

As humans continue to transform forest land into farms and suburban housing, we cause many animals to disappear from their natural habitat. Some animals are negatively impacted if their main survival resources are removed. However, some species do better when wild habitats are disrupted. They often thrive in places where humans live. The researchers set out to understand whether these animals are more likely to carry pathogens that are harmful to humans.

Researchers in the study first used a database called PREDICTS, which stands for Projecting Responses of Ecological Diversity In Changing Terrestrial Systems. This was their first step toward understanding why this happens. The PREDICTS database contains detailed information of the locations where various research studies found different species. This database helps us to analyze how different animal species respond to changes brought by humans in their habitat.

To make the PREDICTS database, researchers used information from other studies that had information about the species present in a location. For each of those studies, they classified the locations according to what they are used for untouched forests, forests recovering after logging, plantation forest, cropland, pasture, and urban. They classified the land by how heavily it is used for that purpose minimal, light, or intense.

The researchers used the PREDICTS database to see which animal species were more likely to be found in areas with a lot of people. Indeed, they did find that some species were more common in those areas than other species. Then they used other databases to look up those animals, to see if they were also known to carry human diseases. Animals that carry human diseases were referred to as host species and those that dont are referred to as non-host species. They used a strict definition of a host which was when a species either got sick from a disease causing pathogen, or if the species was found to carry the pathogen, even if it doesnt get sick from it.

Their dataset contained associations between 3,883 animal species and 5,694 pathogens. An association between an animal and a pathogen means that the animal was found to be capable of hosting a pathogen that can infect humans. But, it doesnt necessarily mean that the pathogens will be transmitted to humans.

Some species were not associated with any pathogens at all. This may simply be because there havent been enough studies done on those species. To account for this possibility, the researchers used a statistical method called bootstrapping. For example, if a particular kind of mouse was not associated with any pathogens, but a related species of that mouse had been studied more thoroughly and found to be a host, that mouse would also be classified as a host.

The decision to reclassify an animal as a host was not arbitrary. Bootstrapping is a mathematical procedure. The researchers began by stating two reasons that an animal might be misclassified as a non-host that animal might not be a host very often among others of its kind, and it might not be found to harbor human pathogens very often when it is studied. The researchers considered the probabilities of these two reasons when recalculating their classifications.

After building this dataset, they analyzed it to see if disturbed and undisturbed land had species differences. Overall, their analysis showed that in areas where land has been converted from forests to agricultural and urban lands, the species that are able to survive these changes are more likely to carry human pathogens. There were 21-144% more wildlife species that are known to carry human pathogens in human-inhabited lands than in non-inhabited areas.

Many of these disease-carrying species, such as rodents, bats, and perching birds, are small, highly mobile, and reproduce very quickly. They experience huge population increases in human-altered landscapes. The researchers suggest that it is possible that these species shorter generation times and higher reproduction make it easier for them to adapt to changes from human activity compared to large mammals.

Finding places on Earth for humans to live can be challenging in densely populated areas. To build and expand cities, humans will inevitably continue to alter natural landscapes, increasing our risk of exposure to wild animals that carry human diseases. This research was conducted to understand how human activities affect the environment, and how these decisions impact us in return.

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Small animals that carry disease adapt well to our activities A study suggests that small mammals - Sciworthy

Is It Safe to Work With Your Laptop on Your Lap? – InsideHook

A year ago, the number of Americans working from home stood at just under five million. These days, its up around 70 million. Thats hard to process. We moved almost half the nations workforce home in a matter of months. And while some still treat it like a temporary measure water cooler chat now is just Zoom riffs on the question When do you think were going back? any shift that seismic comes with a measure of permanence.

Stanford economist Nicholas Bloom expects the WFH era to outlive the reign of COVID-19. One survey, which he conducted with the Atlanta Federal Reserve and the University of Chicago, found that even after the pandemic dust settles, most top firms plan to keep employees home one to three days a week. That will change the world. Corporations will reconsider the value of a downtown high-rise. Workers without fast home internet will be left behind. Transit services will need to reconfigure their long-term goals.

Thats big-picture stuff. But extending telecommuting will result in countless tiny consequences, too some of them alarming. Just look at the habits youve picked up during quarantine. Are you prepared to keep them for years? Like, snacking all day. Checking emails hours after you logged off. Or working with your computer balancing on your lap.

Im especially guilty of that last one. Sometimes, in order to get my act together and draft an email, I need a change of scenery. There are only so many options in the house, so I move from the desk to the couch. Other days I climb back into bed (or put off ever leaving it), in order to get work done. I would guess Im not the only one. But is that a good idea, really? Is it okay to have a hot machine sitting directly atop your nether regions for hours at a time?

In the past, this wasnt much of a problem because it wasnt much of an option. Unless you worked in one of those open-floor startups, chances are you werent putting your feet up on a poof during the workday. But in a world that seems determined to not go back to normal, its important to know how a consistent laptop-on-lap routine could affect the body. Below, we break down four side effects commonly associated with the practice, and your risk of each.

Michael Oxendine/Unsplash

Male infertility is the first issue that comes to mind here. Theres a reason for that. In 2005, Human Reproduction published a study titled: Increase in scrotal temperature in laptop computer users. The conclusion was laptops could raise the temperature of a lap by five degrees Fahrenheit. Remember what laptops looked like in 2005, though? They were as thick as textbooks. Their cooling systems were useless.

A 2011 study, meanwhile, found that heat from a laptop could raise the temperature of yourscrotumby up to 2.8 degrees Fahrenheit. To be sure, any heating of that area is not a great idea; your testicles dangle for good reason sperm production occurs at around 93.2F. Thats well below the normal body temperature of 98.6F. The more sperm you make, the better chance you have that a few of them will be properly-shaped, straight swimmers.

But for years now, urologists have agreed that sitting with a laptop over your pants will not be the reason you lose fertility. That information hasnt exactly filtered its way through the public yet. Perhaps people have been reticent to ask, fearful that the answer they might hear. If youre struggling with fertility, you probably shouldnt plant something hot on your privates why risk it? but that falls in the category of low-caliber behavioral changes, like opting to wear loose-fitting boxers to bed.

There are larger forces at play that will damage your sperm count. Like obesity, drug or alcohol abuse, chromosomal defects, prior surgeries, and infections. If working with a laptop is going to lower your sperm count, itll be from working at night and missing out on sleep. Graveyard shifts have been linked to insomnia, which adversely affects fertility.

A close cousin to the sperm count discourse. People like to cite RFR, or radio frequency radiation, as another reason to keep the laptop away from the body. This point is reminiscent of the stand too close to a microwave and youll catch cancer myth. But radiation youre exposed to from long periods with a laptop is about the same amount youd experience from flying across the country. In other words, its not something to get too worked up about.

This condition has three over-the-top names: academic branding, toasted skin syndrome and erythema ab igne. Buckle up, cause its a doozie. Back in the day, elderly people used to sit too close to open fires or electric space heaters. Without central heating, it was more common for those who desperately needed heat to crowd around a single source. Over time, that habit could result in a reticular pigmented dermatosis, which is a fancy way of saying a big red rash.

The modern comeback of erythema ab igne, while still uncommon, has been fueled by direct contact between computers and thighs. When skin is consistently exposed to the surface of a laptop say, for at least six months, according to one study its at an increased risk of looking like this. Hence the fun nicknames. The key, clearly, is to make sure theres at least a pair of jeans (if not a pillow or blanket) in between you and the device.

Male infertility, radiation and skin scalding are essentially fringe fears of getting too intimate with your laptop. They could happen, they probably wont; youd be better served just getting off the bed or couch and not taking the chance. That said, one non-negotiable, not-great outcome of sitting or lounging with a computer is the hell it wages on your posture. Weve been beating this drum for a while now.

Looking directly down at a screen puts extreme pressure (up to 50 pounds!) on your neck. It morphs your back into an unnatural C. When staring at your computer, the top third of the screen should be as close to eye-level as possible. That allows your body to stay in a neutral position,whereby the spine is naturally aligned absolutely straight from head to toe. Feet planted firmly on the floor is extra credit.

This is why its worth setting up your WFH space correctly. Get a chair that doesnt want to destroy your back. Pick up a laptop stand. And experiment with other floating stations throughout the house; if you really have to sit at the couch, put a raised platform on your coffee table. Books and boxes can help you out there. Or pick up an adjustable tripod desk, which will give all sorts of heights to play with.

It might seem strange to worry about posture in the middle of a pandemic. But the world the pandemic has created isnt going away and the habits we create now are likely to stay, too. Give your back a break, keep your testes cool, and duck that toasted skin nonsense, too. Take the laptop off the lap.

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Is It Safe to Work With Your Laptop on Your Lap? - InsideHook