Terry McLaurin says chemistry, confidence there with Ryan Fitzpatrick already – Yahoo Sports

'Fitz is fun': WFT receiver McLaurin gives rave review of new QB originally appeared on NBC Sports Washington

During the first two seasons of his professional career, Terry McLaurin has caught at least one pass from seven different players andsix different quarterbacks.

Yet, despite having to be on the receiving end of the quarterback carousel in Washington -- one that has spun faster than a Trevor Bauer off-speed pitch -- McLaurin has blossomed into a promisingyoung pass-catcher.

This past offseason, Washington signed veteran quarterback Ryan Fitzpatrick in free agency, a player that, if all goes well, should be an upgrade over every other signal-caller that McLaurin has played with thus far in his NFL career.

McLaurin got his first taste of what it's like catching passes from the 17-year NFL veteran during Washington's OTAs the past two weeks, and the rising third-year receiver is already starting to feel chemistry building between them.

"We've definitely been able to iron out some things early and made some connection over the past few days," McLaurin said on Thursday via Zoom."It's starting to feel a lot more natural and being able to get that head start before camp is [really] good."

It's not just Fitzpatrick's ability on the field that has impressed McLaurin, either. McLaurin mentioned that his new quarterback had already been studying his film from last year and even showed him some clips of him running routes that were similar concepts of what Fitzpatrick had run in Miami the last two seasons.

"He's also a student of the game. He's super smart," McLaurin said."It helps me out because I get to try and see the game through his eyes."

McLaurin will likely be Fitzpatrick's No. 1 target in the fall, but the veteran QB is going out of his way to begin developing a connection with the other wideouts on the roster too.

Story continues

"He puts an emphasis on really being in communication with the receivers. That's not just me," McLaurin said."I've seen him communicate with just about every receiver on the roster right now, just about what they're thinking with this route, what they're thinking about with this leverage. I think that is very important to do at this part in the season because you want to try to start making that connection early."

While he's only spent a couple of weeks practicing with Washington so far, Fitzpatrick's veteran presence and command of the offense is already starting to show.

"Fitz is great. The first thing that struck me about him is just that he has a [really] cool, calm demeanor about him," McLaurin said."When he's in the huddle, it's just really collected."

Over Fitzpatrick's lengthy NFL tenure, the quarterback has developed the reputation of having one of the best personalities in the sport. And, while he's still just getting to know his new Washington teammates, it seems his personality is already starting to shine.

"Fitz is fun," McLaurin said, smiling.

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Terry McLaurin says chemistry, confidence there with Ryan Fitzpatrick already - Yahoo Sports

Batteries: The bedrock of the sustainable future | Sponsored – Chemistry World

You can watch the video version of this podcast above, or listen to the audio-only version from the Chemistry in its element podcast feed here:

Or read the edited transcript below.

Ben Valsler

Were in the midst of a climate crisis. In response, countries are pledging significant action to reduce their carbon emissions the European Union intends to be carbon neutral by 2050, for example, and China by 2060. The Paris Climate Agreement was adopted by almost 200 parties in 2015, obliging countries to set out their plans to reduce greenhouse emissions in increasingly ambitious five-year cycles. And carbon consciousness has also made its way into corporate culture, with organisations like BASF aiming for carbon neutral growth by 2030, and General Motors aiming for 2040.

When discussing large-scale carbon reduction, the focus is often on power generation replacing fossil fuels with solar, wind or tidal energy or on new technologies like carbon capture and storage. But for a truly sustainable future, we need a wider view.

Chris Stumpf

Im Chris Stumpf, and I work at Waters Corporation. Im a senior manager, and I focus on market development. Really, what Ive been looking at pretty extensively as of late is the area of electronics, and also sustainability. Ive kind of developed the title of green ambassador within the company because Im tying in a lot of the electronics, especially lithium ion batteries. It connects into carbon neutrality, but also into supporting sustainability goals of a lot of corporations and a lot of countries around the world as theyre trying to meet their carbon neutrality stated goals.

Ben Valsler

Waters Corporation is the worlds leading specialty measurement company they dont make lithium ion batteries or research new sustainable materials themselves, but they develop chromatography, mass spectrometry and thermal analysis techniques that enable scientists and industry worldwide to answer cutting edge questions.

Chris Stumpf

I think there is a common thread with this, and I think a lot of this is really accelerated due to Covid-19. What weve discovered is that supply chains are being disrupted and theres this need to be able to manufacture within countries. A lot of the supply chain, as it stands now, is not sustainable. So one way of reducing that is to use 5G, which enables the Internet of Things, which enables automated manufacturing. Theres also artificial intelligence, which can be focused directly on managing specific aspects of the supply chain, and continuous manufacturing, things like that. The underlying technology for a lot of that is energy, and how you can store and use energy where it needs to be used. One way to do that is with batteries, specifically lithium ion batteries. Theyre the dominant battery type today. Currently, they enable electric and hybrid electric cars, and theyre used in the electric grid, for smart grids. Their use is going to be very pervasive across the landscape. In addition, theyre heavily used in consumer electronics, our smartphones and our laptops, and all these types of devices that we use nowadays.

Ben Valsler

While all of these technologies play a role in fostering development and reducing our reliance on existing, outdated infrastructure, batteries perhaps seem the least exciting on the list. Its only about 30 years since the first commercial lithium ion battery, but in that time theyve become ubiquitous, commonplace, even forgettable.

Chris Stumpf

AI and 5G receive a lot of publicity. I mean, theyre even in pop culture you can think about Stephen Kings novel Cell, based on creating zombies with cellphone towers. And Steven Spielberg had a movie in 2001, based on artificial intelligence and creating like an [artificial] human person.

But right now, were taking this lithium ion battery technology for granted. Its everywhere: its in our laptops and our cell phones. And theres still a lot to be done.

The chemistry Nobel prize winners in 2019, Goodenough, Wittingham and Yoshino-san, said there are six things that still need to be done with regards to research: reducing the cost, improving the safety, increasing the charge density. For example, if youre going to put these lithium ion batteries on an aeroplane, or a big tractor-trailer truck or something like that, you need a lot more energy density.

Then theres the question of whether lithium ion battery technology, as its being practised today, with the liquid electrolyte fluid and the cathode and anode, is the right approach. Should we go with another type of technology? Do we use solid state, for example? Or do we replace the electrodes with other types of technology? The lithium and cobalt that are in the anode and cathode are not really that sustainable its a bit difficult to justify this from a sustainability perspective. Could you perhaps replace some of that with more common metals like sodium? Theres a lot of opportunity here for really basic R&D to decide which direction to go in, and which is the most commercially viable option.

Ben Valsler

Sustainability means different things to different people. For a business strategy to be sustainable, it needs to ensure profits are greater than costs. But this can conflict with the environmental bottom line ensuring no environmental or ecological damage to sustain the natural world for generations to come. Taking a global view, the United Nations has set out 17 sustainable development goals, which include affordable and clean energy, climate action and responsible consumption and production alongside gender equality, sanitation, peace and justice.

Chris Stumpf

In addition to a clean environment, they also want to promote civil stability, because they want to minimise extreme wealth inequality to reduce the possibilities of war. So with regards to lithium ion batteries, that framework of sustainability and trying to source your materials plays a part in those 17 development goals of the United Nations. Thinking about the Paris Climate treaty, if we can maintain our carbon emissions to 1990 levels, then we can arrest the increase in the Earths temperature. Basically, that justifies the investment in all this R&D for lithium ion batteries and all the products they are going into.

Yoshino-san talked about lithium ion batteries being the bedrock of the sustainable society. But theres other things that we dont quite realise, until we get to that world of having a lot of our consumer electronics and cars and aeroplanes and things like that running on lithium ion batteries or another alternative. Its an enabling technology. Its playing a small part in this overall scheme of sustainability. Its not the only thing thats going to help with this, because its kind of a hybrid situation where we have lots of things that we need to do in order to reach a sustainable future, but its the foundation of that, in my opinion.

Ben Valsler

If batteries are to be the bedrock of the sustainable society, its vital that we understand how to tailor them to specific uses the battery in your laptop has a very different specification to the ones in the latest electric cars. This is where measurement technologies come into their own, helping with everything from blue-skies research to efficient manufacture.

Neil Demarse

Hi, my name is Neil Demarse. I am a product manager for our microcalorimetry products.

Because theyrecontained and non-moving, you can think of batteries as a machine almost. Its a complex device. Theres not a lot of techniques that can be used to study whole cell batteries. A lot of them are destructive techniques. Having a test that you can use to look at the chemicals separately, but also look at whole cell batteries is important. Thats where calorimetry really has a very important contribution to the research field.

Research is also starting to look at bringing in some of the tools that biochemists or biopharmaceutical sciences are using because of their sensitivity: HPLC and mass spectro
metry. Theres also cryo EM, which was historically used just in protein science; now, its being carried over into material characterization for batteries. As the batteries change and the performance demands accelerate, thats where theyre drawing in some of these tools that wouldnt traditionally be used by chemical engineers or chemists. Theres not a one-size-fits-all battery, so theres going to be a lot of research to determine how best to build certain batteries for certain applications.

Chris Stumpf

In order to think about things like safety or energy density, as far as an analytical characterization perspective, you have to go back and think about the battery itself. Theres four primary things that you have to think about when you when you think about a battery. Theres the anode and the cathode, and were all familiar with the terminals of batteries that is basically the anode and the cathode. Inside, there is the electrolyte. Theres additives and all this stuff that is put in there partly to enhance the performance of the battery, but also to suppress potential fires and things like that. Then on the inside, there is a polymer separator. Its purpose is basically to prevent a short circuit between anode and cathode. If you actually have a short circuit if the polymer gets punctured, or if it shrinks the battery gets hot very quickly. And if the battery gets hot very quickly, it can cascade because a lot of the time, these cars will have thousands of these batteries in in a battery pack. It can cascade like dominoes.

Neil Demarse

Calorimetry can tell you how fast reactions are happening, how much of a reaction is happening, even the fact that there is a reaction happening [at all]. So a researcher might have some data on their chemistry before it goes into the battery, or if you were to cut it open, but calorimetry tells you how all those components together react are there reactions in there that we dont want? Were measuring heat; do those reactions get too hot?

The chemistry that goes into the battery is going to help the charge density and the battery life cycle. Safety is also something that can be looked at early on in the R&D process to make sure that chemicals are compatible. High-precision coulometry is another technique thats paired with calorimetry to understand these parasitic reactions, the small minute reactions that researchers want to understand because it points directly to how good their batterys going to be.

Chris Stumpf

But youve also got the capabilities of really understanding the chemistry thats going on, and all the side reactions. These side reactions basically rob the battery of its main goodness: the power that its generating. If you can understand that from a molecular perspective, with techniques such as mass spectrometry, or maybe for the whole battery itself using battery calorimetry, then you can really get to understand how you can actually make this battery last 20 years, 40 years, 100 years.

Ben Valsler

Fine-tuning the chemistry within a battery isnt enough to make a perfect product the right battery case is essential to allowing that chemistry to work in situ. To confirm a case wont collapse in the real world, researchers use techniques like thermo-gravimetric analysis, or TGA. By applying heat to a material in a controlled way, they can precisely measure not just physical deformation, but chemical changes that would indicate degradation or oxidation.

Chris Stumpf

The polymer that the casing is made out of is actually very important. Youd like to make a casing thats resistant to being crushed in a car accident, for example.So you can design a casing and use analytical characterization in order to build that polymer so that it resists that. You can put the right additives in the electrolyte on the inside so that if the thing does start to heat up, it can trigger some type of flame repression. Theres a number of these things that you can do from an analytical perspective to build a high performing battery that that has a lot of the energy performance that you want. But at the same time youve got to think about the safety perspectives as well.

Ben Valsler

One essential component of a sustainable future highlighted by the United Nations goal of responsible consumption and production centres around what happens to a product at the end of its useful life. Electronic waste is a growing problem the UN estimated 50 million tonnes was reported in 2018, and levels are expected to double by 2050. This includes complex equipment that is hard to recycle and can contain components that are toxic or hard to replace creating a vicious circle whereby materials are mined in environmentally damaging ways, only to be returned to landfill in just a few years. With batteries, as with other electronic components, research and characterisation can help us to reduce, reuse and recycle.

Neil Demarse

Theres a lot of work going into understanding recycling. Apple is one of the largest recyclers of batteries in the world. Its no surprise they have batteries in all of their devices. Im sure they want those back and they have a process that might be able to recycle some or all of the battery. Theres lots of other techniques, but there are still questions: how do you take something thats a static machine full of chemicals and take it apart? How do you recycle these small little pieces? Theres some initiatives or research that go into, were going to grind up the battery and try to purify certain parts of it by just making it smaller and smaller and smaller, mechanically. Others, open up a battery and extract certain materials, but I think it is a big challenge understanding how batteries are going to be recycled. Whats the best way to do that? I dont think it necessarily fits our current recycling process as we know it of separating [components]. Its easy to separate trash. With batteries, its a lot more complex.

Chris Stumpf

Right now, theres regulations in order to collect these batteries, because we dont want them to get into the waste stream. But as far as collecting enough material to reuse it, I think the amount of electric cars is actually not high enough to make that economically feasible. Theres two major areas that people look at with regard to recycling batteries. The first is relatively straightforward: you take the battery pack in some kind of casing from a car, you open that case off, and theres all these individual battery cells. You can test each one of those cells and you can pull out the ones that are bad and replace them with good ones. Then you can repurpose that battery pack, either by putting it back into another car, or you can put it into a Smart Grid, which might have less aggressive energy requirements. It actually might last a lot longer in the electric grid. Its basically a reconditioning of the battery.

The second one is to take that battery pack out of the car or the cell phone or whatever, open up the battery pack, take out the cells, and grind them up. Then try to separate things into cobalt, magnesium, lithium etc. to get back to virgin materials. Thats another area where you need analytical characterization; you need mass spectrometry, NMR, TGA, DSC, all these types of techniques in order to just understand the physical properties and the molecular properties of this, and to see if youve actually got yourself back to where you want to be.

Ben Valsler

Pure, virgin materials have fairly well understood properties. But when a material has been reclaimed from a disused battery, we need to be certain that it will behave in the same way before it returns to the manufacturing process. With many companies operating on a financial knife edge, the risks of using recycled or reclaimed materials that may contain impurities can be too much to bear.

Chris Stumpf

Without the analytical characterisation, without the molecular understanding of the anode and the cathode material, the electrolyte, and the polymer materials that the the battery cells made out of, without that molecu
lar and physical understanding with a TGA, you can actually take that polymer and you can melt it with a thermoplastic. You need to know when these polymers melt, because thats part of the manufacturing process. You melt these polymers and then you blow mold them, or you do different types of manufacturing with them. But you need to be able to understand that because if the temperatures shifted, somehow, its not going to work in the existing manufacturing process, and youre going to have to do all this adaptation. So really, you need to understand, Do I still have that same polymer or has it has it degraded somehow? If you take a polymer from a battery, for example and use it in a different application, maybe in a car bumper, if that polymer now is brittle, its going to break right away. Its not going to be a good application in a car because you need that bumper to resist that impact. So absolutely, analytical characterisation across the whole, from the very beginning of making a battery to the circular economy and reusing the components, youve got to understand that from each step of that process.

Ben Valsler

So as we collectively try to find ways to adapt to a challenging future, to meet the ambitious targets we set for our varying definitions of sustainability, its essential that we use every tool available to us to probe, analyse and understand the technology that we take for granted. And with that understanding we will be able to build, and rebuild, better batteries that can realise Akira Yoshinos vision of them as the bedrock of a sustainable society.

For more on this topic, check out the new Chemistry World sustainability collection curated content created with our partners. You can find that at chemistryworld.com/sustainability.

This podcast featured Chris Stumpf and Neil Demarse of Waters, and was produced in partnership with Waters Corporation. Im Ben Valsler from Chemistry World, thank you for joining me.

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Batteries: The bedrock of the sustainable future | Sponsored - Chemistry World

Nick Saban is ‘excited’ about the chemistry this Alabama team has the potential of having – Touchdown Alabama Magazine

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Nick Saban could not hide his excitement when it came to discussing certain players during spring practice.

After securing his second undefeated national title at Alabama, he graduated marquee playmakers to the National Football League.

Some are concerned about how the Crimson Tide will look offensively; however, others are prepared to see a fearsome defense take the field in the fall. When he was not talking about COVID-19 vaccinations, name-image-and-likeness, or the explosion of graduate transfers, Saban spoke on the potential chemistry of this years Alabama team. He had a first-year starting quarterback in Mac Jones win a national championship, but now the mantle falls on sophomore Bryce Young for a repeat.

Well, its always a working progress but I do think the summer program is where the leadership on the team has the best chance to flourish, Saban said at the Old Overton Golf course. The coaches are not always around, so the players have more input. Weve had our annual leadership on the lake, and I think the players are excited about the opportunities and challenges this season will bring.

Offensively, names such as Brian Robinson, Evan Neal, Chris Owens, John Metchie, Slade Bolden, and Jahleel Billingsley have to dictate the temperature in the room. Alabama carried a young offense in 2011 and 2015; nevertheless, both groups won a national championship.

It will be intriguing to see how this team stacks up, but it knows the mentality it must have to win consistently.

The Tide is going after its second repeat since the 2011 and 2012 seasons.

*Get the BEST Alabama football insider information, message board access, and recruiting coverage today!SIGN UP HEREto unlock our subscriber-onlycontent!*

Stephen M. Smith is the managing editor and seniorwriter forTouchdown Alabama Magazine. Youcan like him onFacebookor follow him on Twitter, via@CoachingMSmith.

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Nick Saban is 'excited' about the chemistry this Alabama team has the potential of having - Touchdown Alabama Magazine

Brooklyn Nets get an A+ on their chemistry test, cruise to easy NBA playoff win over Celtics – Yahoo Sports

Remember the storyline that the Brooklyn Nets might struggle in the postseason as the chemistry among their All-Star trio develops? Well, never mind.

The Nets defeated the short-handed Boston Celtics, 141-126, with Kevin Durant (42), Kyrie Irving (39) and James Harden (23) combining for 104 points. And Harden added a career playoff-high 18 assists as the Celtics took a 3-1 series lead over the Celtics.

With Durant, Irving and Harden playing just eight games together in the regular season, it might seem that the Nets would need some time to figure out how to best complement each other even as they downplayed such talk.

Irving rebounded from a poor-shooting Game 3 loss by hitting 6 of his 12 3-pointers. After the game, a fan threw a water bottle at him as he left the court.

Mental toughness? One of the best Ive ever seen. For him, all the emotions or whatever is going through his mind, which Im sure a million things go through his mind, Harden said of Irving. He goes out there, blocks everything out and just (is) himself and from a guy that probably would say he didnt play his best game in Game 3, came in and had a killer instinct, killer mentality, and had a will to win Game 4. It showed. He was aggressive, and when Kais aggressive like that, nobody can guard him. That gives our team energy as well. Big-time effort from him, big-time effort from our team.

It helps that they are playing a short-handed Celtics team missing Jaylen Brown (out for the playoffs, wrist surgery) and Kemba Walker (out for Game 4 with left knee bone bruise).

Durant is averaging 34.7 points, Harden is averaging 26.2 and Irving is at 24.7.

The 104 points scored by Durant, Irving and Harden tied an NBA playoff record for three teammates set by Boston's John Havlicek, Jo Jo White and Dave Cowens in 1973 and matched in 1986 by Dominique Wilkins, Randy Whitman and Spud Webb.

State of the series: Nets lead 3-1. Game 5 is Tuesday in Brooklyn (7:30 p.m. ET, TNT)

Story continues

James Harden had 23 points and 18 assists in the Nets' 141-126 win over the Celtics on Sunday.

The Clippers claimed there was no reason to panic after they were swept in the first two games of this playoff series at home. It appears they were right. The Clippers are showing the kind of resilience expected of a title contender by overpowering the Mavericks from the start to even up their series. Kawhi Leonard led the way with 29 points on an efficient 11 of 15 shooting. And suddenly, the Clippers may have revived their title-contender status. At the very least, they regained home-court advantage. Were where we were supposed to be, said Nicolas Batum. We're supposed to be at 2-2, technically. So we're going to go home and have to take care of home court. Mavericks star Luka Doncic, who had 19 points on 9 of 24 shooting, was certainly in pain, coach Rick Carlisle said, after he played through a strained neck for a second consecutive game.

State of the series: Series tied 2-2. Game 5 is Wednesday in Los Angeles (10 p.m. ET, TNT)

Its easy to think of the Hawks as a solo act. Trae Young is clearly their leader, but their supporting cast isnt bad, either. John Collins contributed 22 points and Danilo Gallinari added 20 to support Youngs 27 points to help the Hawks take a 3-1 series lead. The Hawks have a chance to advance out of the first round of the postseason for the first time since 2016. We have so many guys who are skilled with the basketball, Collins said. We have great chemistry with each other. I think the sky's the limit with this team when we do the right things.

State of the series: Hawks lead 3-1. Game 5 is Wednesday in New York (Time TBD)

The Phoenix Suns got even Sunday. With stifling defense and balanced offense, coupled with Anthony Davis missing the second half with a groin injury and Chris Paul playing his best ball since injuring his right shoulder in Game 1. The playoffs bring you to your limits in a lot of ways and that's how you grow, Suns coach Monty Williams said. You're watching our young team grow on the fly. With Davis out and Paul looking more like himself in posting a team-high 18 points, nine assists and zero turnovers in 32 minutes, Phoenix returns home with huge momentum for Tuesday's Game 5 at Phoenix Suns Arena.

--- Duane Rankin

State of the series: Series tied 2-2. Game 5 is Tuesday in Phoenix (10 p.m. ET TNT)

NBA PLAYOFF SCHEDULE: First-round matchups, results, game times and TV info

Joel Embiid has been the dominant force and is easily having the best postseason of his career. That is why the Sixers, the No. 1 seed in the Eastern Conference, have a chance to sweep their first playoff series since 1991 when they beat the Milwaukee Bucks 3-0. Embiid had a career playoff-high 36 points on 18 shots in Game 3. I cant imagine anybody playing better than him, Wizards coach Scott Brooks. As a result, the Sixers definitely have a sweep on their mind. We want to get the sweep so we can get some rest, 76ers guard Ben Simmons said. But this is a tough team. You never know what you are going to get every night, especially with [Bradley] Beal and [Russell] Westbrook. So weve got to come prepared on Monday.

State of the series: Sixers lead 3-0. Game 4 is Monday in Washington (7 p.m. ET, TNT)

The last time the Grizzlies were in the postseason, Mike Conley was one of the main reasons they got there. In their first trip back since 2017, Conley might be one of the main reasons for their early exit. The former face of the Grit and Grind Grizzlies that made seven straight trips to the postseason, Conley is having the kind of success in Utah that he had in Memphis. And that is good news for the No. 1 Jazz. He has averaged 23 points against the Grizzlies, helping the Jazz to a 2-1 series lead. Mike was terrific on both ends of the floor. He was Mike Conley, Donovan Mitchell said after Game 3. And he always has been for us all year, and he's taken it to an even another level. And I feel like when you have a guy like that who can handle the ball, who can control the game, as well, it makes my life and my job easier. So when I get certain shots, it's because he sees things, he's communicating that with me or he's putting me in positions to go ahead and score and make plays too. A lot of that too is Mike Conley being here. He's big time.

State of the series: Jazz lead 2-1. Game 4 is Monday in Memphis (9:30 p.m. ET, TNT)

If you study a box score of a Trail Blazers game and discover that Damian Lillard shoots 1 of 10 from the field, there wouldnt be much expectation of a successful outcome for Portland. But Lillard had just 10 points in Game 3, and the Blazers defeated the Nuggets 115-95. Norman Powell, who won an NBA championship with the Toronto Raptors in 2019, picked up the slack. Powell led the Blazers with 29 points to help the Blazers even the series. If he continues to play well and Lillard rebounds, the Blazers could make make trouble for the Nuggets. I love these types of games, these kinds of moments. It's the moment where nothing else matters, Powell said. You get caught up in the course of the season with stats sometimes, this-that-and-the-other, road trips, but when you get into the playoffs, the only thing that matters is winning.

State of the series: Series tied 2-2. Game 5 is Tuesday in Denver (9 p.m. ET, NBATV)

This article originally appeared on USA TODAY: Brooklyn Nets' Big 3 had record-scoring night in cruising past Celtics

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Brooklyn Nets get an A+ on their chemistry test, cruise to easy NBA playoff win over Celtics - Yahoo Sports

A Glowing New Weapon in the Fight Against Antibiotic-Resistant Bacteria – SciTechDaily

A new chemical probe glows in the presence of a bacterial enzyme that contributes to antibiotic resistance. Credit: The University of Texas at Austin

In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments for bacterial infections.

A research team led by scientists at The University of Texas at Austin has developed chemical probes to help identify an enzyme, produced by some types of E. coli and pneumococcal bacteria, known to break down several common types of antibiotics, making these bacteria dangerously resistant to treatment.

In response to antibiotic treatment, bacteria have evolved various mechanisms to resist that treatment, and one of those is to make enzymes that basically chew up the antibiotics before they can do their job, said Emily Que, assistant professor of chemistry and one of the leading researchers on the team. The type of tool we developed gives us critical information that could keep us one step ahead of deadly bacteria.

In a paper published online on May 26, 2021, in the Journal of the American Chemical Society, the researchers zeroed in on the threat posed by the bacterial enzyme called New Delhi metallo-beta-lactamase (NDM). They set out to create a molecule that glows when it comes into contact with the NDM enzyme. When these chemical probes are added to a test tube, they bind to the enzyme and glow. Such a tool could be used to alert doctors to what kind of bacterial threat is affecting their patients and tell them which antibiotics to use.

NDM breaks down antibiotics in the penicillin, cephalosporin and carbapenem classes, which are some of the safest and most effective treatments for bacterial infections. Other classes of antibiotics exist, but they may carry more side effects, have more drug interactions and may be less available in some parts of the world.

In addition to indicating the presence of the NDM enzyme, the florescent chemical probe developed by Que and Walt Fast, a professor of chemical biology and medicinal chemistry, may help find a different way to combat these resistant bacteria. One treatment option that doctors use with resistant bacteria is to combine common antibiotics and an inhibitor. Although there is no known clinically effective inhibitor for NDM-producing bacteria, Ques probe could help find one.

Once the probe has bound to the enzyme and begun to glow, if an effective inhibitor is introduced, it will knock the probe loose and the glow would stop. This allows scientists to test a high volume of potential drugs very quicklyresearch Que and Fast hope to continue in the future.

This allows us to work towards developing therapies and eventually understanding evolutionary characteristics of such proteins, said Radhika Mehta, a recent UT Austin doctoral graduate and lead author on the paper. Mehta is currently a postdoctoral fellow in the Merchant Lab at the University of California, Berkeley.

The study also examined a process called nutritional immunity, which comes from the human bodys production of proteins in response to an infection. The proteins snatch up all the available metals in the body, such as the zinc required to make NDM, rendering the bacteria more susceptible to attack.

The evolution of this bacteria since its discovery in 2008 indicates that not only is it developing antibiotic resistance, its attempting to combat this natural human immune process. Thats particularly scary, Que said.

Ques probe can also be used to study nutritional immunity and NDM because it will glow only in the presence of the zinc needed to form the enzyme.

Reference: Visualizing the Dynamic Metalation State of New Delhi Metallo--lactamase-1 in Bacteria Using a Reversible Fluorescent Probe by Radhika Mehta, Dann D. Rivera, David J. Reilley, Dominique Tan, Pei W. Thomas, Abigail Hinojosa, Alesha C. Stewart, Zishuo Cheng, Caitlyn A. Thomas, Michael W. Crowder, Anastassia N. Alexandrova, Walter Fast and Emily L. Que, 26 May 2021, Journal of the American Chemical Society.DOI: 10.1021/jacs.1c00290

Radhika Mehta, Dann D. Rivera, Dominique Tan, Pei W. Thomas, Abigail Hinojosa, Alesha C. Stewart and Walter Fast of The University of Texas at Austin; David J. Reilley and Anastassia N. Alexandrova of the University of California, Los Angeles; and Zishuo Cheng, Caitlyn A. Thomas and Michael W. Crowder of Miami University also contributed to the research. The research was funded by the National Institutes of Health, the National Science Foundation and the Robert A. Welch Foundation.

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A Glowing New Weapon in the Fight Against Antibiotic-Resistant Bacteria - SciTechDaily

Chemical reaction sends plume of orange smoke into air on east side, leads to shelter in place advisory – Fox 59

INDIANAPOLIS Local businesses were evacuated, and neighbors were advised to stay inside, after a chemical reaction sent a plume of orange vapor into the air on the east side.

The Indianapolis Fire Department and Marion County Public Health Department were called to 2728 N. Emerson Ave. Thursday morning.

IFD said the orange cloud, which was visible along I-70, resulted from a reaction between nitric acid and moisture inside a container. The reaction pushed smoke into the area, which quickly began to dissipate.

IFD urged neighbors to shelter in place and close their doors and windows. Nearly 30 people were evacuated from a pair of nearby businesses as a precaution, IFD said.

The vapor can be irritating to the eyes and lungs, IFD said, adding that hazardous material crews were responding to the scene.

The Marion County Public Health Department said it would assist with monitoring air quality.

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Chemical reaction sends plume of orange smoke into air on east side, leads to shelter in place advisory - Fox 59

The limits of life – The Indian Express

A curious side-effect of sentience is the awareness of death. Medicine, wellness, meditation, philosophy, neural transfers, even literature and the arts a great deal of human endeavour is tasked with either trying to prolong life, or deal with the reality of its end. It turns out that even the best efforts at least those that aim at corporeal immortality and longevity are bound to be futile.

According to a study published in the journal Nature Communications, the human body cannot survive beyond the age of 150 years, eating right and exercising notwithstanding. Researchers used a combination of data from blood tests from over five lakh people as well as mathematical modelling to conclude what we all know already: Everyone is going to die. The body will deteriorate to such an extent that it will not be able to fight disease or recover from even minor injuries. Despite the obviousness of the finding, its implications are serious. Prolonged old age already, human beings are, on average, living longer than ever before means that the burden on the working population is bound to increase, and that retirement will have to wait for many. After all, if youre going to live to 150, its hardly possible to stop earning at 60. And, to make matters worse, there is no guarantee that the quality of life at 150 will really be something worth living for.

The fear of death, and the futility of life, is of particular resonance now the pandemic has made people confront their own mortality on a scale not seen since World War II. In the aftermath of that war, the absurdity of social norms and ambition was articulated by the existentialists. This time, perhaps, the lessons that are drawn will be a little more hopeful: At the end of it all, people may simply give up the race against death and see that theres more in the moment than planning for a future that can be robbed by a microbe.

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The limits of life - The Indian Express

Aging with vitality – University of California

If being sedentary is the new smoking, then UC Irvines nascent Exercise as Medicine class is the modern equivalent of the old surgeon generals warning on cigarette packs.

Taught byJames Hicks, professor of ecology & evolutionary biology, the course examines the hazards of physical inactivity and explores how exercise not only improves overall health but can even alter or reverse the trajectory of cancer and other diseases.

Hicks says he created the class which debuted this spring with 85 biology students and turned away another 179 to spread the gospel of walking, running and other forms of exertion.

Because many biology majors go into medicine, Im trying to make them converts who will tell their friends, parents, aunts, uncles, grandparents and patients that regular physical activity is like a fountain of youth, he says.

For decades, science assumed that the gradual decline of physiological performance as people grow old was a fixed slope, and by age 65 or 75, youre supposed to be sitting in a rocking chair, Hicks says. We all die, but the slope can be altered.

About 20 years ago, researchers discovered that intense movement causes muscles to release chemical compounds that boost health, immunity and longevity, he notes. It wasnt an entirely new concept. Around 600 B.C., a physician in India prescribed daily exercise to his patients. And Hippocrates described walking as mans best medicine.

Today there are reams of studies to back up these ancient suppositions. Ive collected gigabytes of literature on the connection between physical activity and health, says Hicks, who previously directed UC Irvines Center for Exercise Medicine & Sport Sciences (now theCenter for Integrative Movement Sciences).

One of the subjects in his syllabus is the burgeoning field of exercise oncology. UCLA, UC San Francisco, Harvard University and New Yorks Memorial Sloan Kettering Cancer Center are among the medical institutions that recommend exercise as part of cancer treatment, he says, adding that specific activities can help with certain tumors. For example, breast cancer patients who walk briskly for three hours a week after receiving standard treatment have been reported to enjoy 32 percent better outcomes, a success rate few drugs can match, Hicks says.

Other lecture topics include exercise and diabetes, heart disease and brain health. Although theres no lab component to the course, students log their activity levels and calculate how many calories they burn. At the beginning of the quarter, Hicks polled the class on how they spend their downtime and created a word cloud to display the results. The No. 1 leisure activity: watching YouTube.

Hicks hopes students will be less sedentary by the end of the course. One of the reasons the U.S. was hit so hard by COVID-19, he says, is that too many Americans are obese.

Known for his research on vertebrate hearts, Hicks, 67, practices what he teaches, bicycling 60 to 120 miles a week, walking to campus every day and taking stairs instead of elevators for climbs under five floors.

At the end of the Exercise as Medicine class, he plans to show aone-minute Canadian videothat asks, What will your last 10 years look like? Using a split screen, it depicts the same actor in hauntingly parallel scenes, one version healthy and the other sickly. A key to finishing life on the healthy side, Hicks says, is staying physically fit: We can age with vitality. Its never too late to get started.

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Aging with vitality - University of California

Slash Your Cancer Risk in Seconds, Say Cancer Experts | Eat This Not That – Eat This, Not That

You're about to hear advice from the last people you'd ever want to meet. Oncologists specialize in the diagnosis and treatment of cancer. If you're talking to one, and you're not at a dinner party, you might be one of the 100 million folks around the world who have it. With those staggering stats, you might think getting cancer is an inevitably. It isn't. Read onand to ensure your health and the health of others, don't miss these 19 Ways You're Ruining Your Body, Say Health Experts.

"I am very careful about keeping up with proven cancer screening interventions," says Amy Tiersten, MD, clinical breast medical oncologist at Mount Sinai. She stays current on preventative tests like colonoscopy, skin cancer exams, and gynecologic follow-ups.

Late diagnoses are a leading cause of premature death due to cancer. Interventions, like those Dr. Tiersten recommends, allow for early detection and diagnosis where patients can start treatment earlier. This is especially impactful in breast, cervical, and colorectal cancers.

The American Cancer Society recommends:

Ten years after the HPV vaccine was introduced, there is "compelling evidence" that we're on track "to eradicate cervical cancer within decades." A June 2019 study reviewed 60 million individuals', mostly girls and women, eight-year post-vaccination status and found that the vaccine has exceeded expectations.

The CDC recommends both boys and girls get the HPV vaccine at ages 11-12, with the second dose within a year. It's recommended up to age 26 for women and age 21 for men.

Newer versions of the vaccine require two doses instead of three, ensuring adherence to the full vaccination schedule. As well, it's gender-neutral and targets more HPV strains.

Exercise every single day that's the walk Kathryn Schmitz, Ph.D., a leading exercise oncology researcher at Penn State University, walks and talks. "We oncologists run, walk, or roll our way to cancer prevention," she said, citing research that supports a relationship between physical activity and cancer prevention. She's the biggest proponent of strength training, something she introduced in the chemo lab at Penn State Cancer Institute and shares as "exercise snacks" each week on her Instagram. "I try to exercise 30 minutes a day to stay fit. We know that regular physical exercise does reduce cancer risk in many cases. Decreasing your body weight, even by 5%, can make a big difference in terms of cancer risk," says Xavier Llor, MD, Medical Director of the Cancer Screening and Prevention Program.

RELATED: The #1 Reason You Could Get Cancer, According to Science

"Embrace your social networks; recognize who loves you and let them in," is how Dr. Don Dizon, MD, FACP, FASCO, director of medical oncology at Rhode Island Hospital and Professor of Medicine at Brown University prevents cancer. He says it's well-established that whether your social network includes a spouse, kids, best friend, or church, these connections are key to good health and that social isolation is associated with an increased risk of death.

"In one study, social isolation scores were associated with risk of death from heart disease and in all-cause mortality. This was true for men and women, Blacks and whites."

As an oncology clinical pharmacist, there are several things Allison Baxley, PharmD, BCOP of Stephenson Cancer Center does to prevent cancer. She recognizes that many elements are out of our control, like genetics, so she does all she can to reduce the risk through things she can control.

"Working primarily in GI oncology, I'm very aware of the link between colon cancer and processed and red meat consumption. I eat these in moderation, and rarely if ever eat highly processed meat like hot dogs and bacon."

She avoids what Micahel Pollen has called "edible food-like substance," which is the majority of what's in the center aisles of the grocery store.

RELATED: Signs You're Getting One of the "Most Deadly" Cancers.

Our daily diet choices play a powerful role in cancer prevention, reminds Dr. Terry Wahls, author of The Wahls Protocol series. For optimal cancer prevention, she aims for 9 cups of plant-based foods each day: 3 cups of greens, 3 cups of sulfur-rich foods like cabbage, onions, or mushrooms, and 3 cups of color from berries.

"We can choose to eat more greens and non-starchy vegetables and berries to markedly reduce the risk of developing cancer (and surviving cancer if it is diagnosed)," she explains. "Or we can choose the standard American diet, full of sugar and flour, which drives up insulin and insulin-like growth hormone and have a much higher risk of pre-cancers and overt cancers."

LaShyra "Lash" Nolen, an MD candidate at Harvard Medical School, points out that Black women have a disproportionately higher rate of mortality from breast cancer than white women, according to 2016 research.

"Therefore, I think it is so important for me, as a young Black woman, to take agency over my body," shared Nolen. "One way I do this is by regularly performing a physical exam of my breasts to search for abnormalities or unusual lumps."

She adds that, sometimes, women allow others to know their bodies better than they do themselves, but that this has to change in order to detect cancers at earlier stages and improve outcomes.

As an American Cancer Society Research Professor and Associate Dean for Oncologic Sciences at Brown University, Dr. Wafik El-Deiry says it's important to remember that half of all cancer is preventable. One of his preventive efforts is to limit or moderate alcohol consumption, as alcohol has been linked to cancers of the mouth, throat, liver, colon, breast, and others.

"Be aware and keep in the back of your mind that this is a substance that can do harm," he advises. El-Deiry says there's a lot of evolving and emerging data on the association between alcohol and cancer, but that the relationship does exist.

How much is too much? The American Cancer Society advises no more than 2 drinks per day for men and 1 drink per day for women.

Jeffrey Meyerhardt, MD, MPH, medical oncologist for the Dana-Farber Cancer Institute, works hard to maintain a healthy body weight. He cites consistent evidence in observational studies that link obesity and higher BMI with a variety of cancers, including colorectal, ovarian, and pancreatic.

In particular, he cited a 2003 study that analyzed the relationship between body weight and mortality from cancer in nearly one million American adults. When the heaviest participants had a BMI of 40, death rates from all cancers were 62% higher in women and 52% higher in men when compared to those of "normal weight."

RELATED: The #1 Cause of Obesity, According to Science

"I eat a balanced diet of real food. The less processed, the better!" says Allison Betof Warner, MD, Ph.D. of Memorial Sloan Kettering Cancer Center. Of course, this melanoma medical oncologist splurges and doesn't always eat healthy (like the rest of us!), but when she does, moderation is key.

While no single food can prevent cancer, a well-rounded diet with a variety of vegetables, fruits, and grains can go a long way toward risk reduction.

"I try to live by the 80/20 rule," she caveats. That's 80% whole, healthy foods in balanced proportions and 20% treats and other "less" healthy stuff.

"I make sure to get plenty of Vitamin D," says Kevin Dawravoo, MD, hematologist and medical oncologist at Northwestern Medicine Cancer Center Warrenville. He cites numerous studies that support the anti-cancer effects of this nutrient. Anyone can check for a vitamin D deficiency with a simple blood test at their doctor's office. That deficiency was linked in a 2014 study to a greater risk for more aggressive prostate cancer.

The best source for vitamin D is the sun, but new research says sunblock does not compromise the absorption of the vitamin. Fish is the best food source for vitamin D, including salmon, rainbow trout, and swordfish, as well as fish oil/cod liver.

Most Americans are "woefully sleep deprived," says Dr. Stephen C Schimpff, MD, MACP. Board certified in medical oncology, Schimpff is sure to "get enough sleep" each night. It's a subject important enough that he addresses it in his book, Longevity Decoded The 7 Keys to Healthy Aging.

"Inadequate sleep predisposes to high blood pressure, stress, overeating [in general] and the wrong foods, obesity, and hence predisposes to cancer," he continued

Monisha Bhanote, MD, FASCP, FCAP meditates regularly, a practice she says can "help balance life's daily stressors." The most benefit is gained from daily practice, even if just five minutes, than if done sporadically.

The triple board certified physician at Baptist MD Anderson Cancer Center says, "Managing stress is important for preventing chronic disease and predisposing one to cancer. Stress weakens the immune system and lowers its defenses to fight diseases." Consistent meditation can move the body into a parasympathetic state (rest and energy conservation) as opposed to a continuous sympathetic state (aka fight or flight).

Bhanote cited a 2004 study that found chronic stress can impair the body's immune response and contribute to the development of cancer.

A variety of sources like cell phones, wifi, power lines, and battery-powered cars bombard us every day with EMFs, or electromagnetic fields. Dr. Jonathan Stegall, an integrative oncologist and medical director of The Center for Advanced Medicine in Atlanta, says he tries to limit his exposure to EMFs.

"I recommend that my patients not hold a cell phone up to the ear, and instead hold it away from the body using speaker phone. This significantly minimizes the amount of radiation absorbed by the body," advises the author of the bestselling book Cancer Secrets. He also recommends installing a timer on any WiFi modem/router at home so that it turns off while you are sleeping.

RELATED: The #1 Reason You Could Get Cancer, According to Science

It's family first for Dr. Timothy S. Pardee, chief medical officer, Rafael Pharmaceuticals and oncologist and director of Leukemia Translational Research at Wake Forest Baptist Health. He believes this time is super important, and notes that familial relationships can reduce stress and increase overall well being.

A global study found that larger families, those with many children, have a reduced risk of cancer. And that's not just the nuclear family. Larger household sizes with multiple generations living together enjoy that same protective benefit. The study authors cite the "special emotional environment" as having a positive effect that contributes to disease resistance, as well as the benefit of family members supporting each other in a healthy lifestyle.

Did you know you can get paid to prevent cancer? Roshni Rao, MD, Chief of the Division of Breast Surgery at New-York Presbyterian Hospital and Columbia University Medical Center and says even she participates in clinical trials. "I was part of an MRI trial where I was in [the] machine for over an hour, and I got paid $25!," she said.

She's also participating in the T-MIST trial, a national study working to identify how often women should get mammograms and what type of mammogram to get. Rao says this trial is currently open at Columbia and seeking up to 165,000 women to participate.

"I drink a few cups of green tea or coffee every day," says William W. Li, MD, author of Eat to Beat Disease: The New Science of How Your Body Can Heal Itself. After 20 years of cancer prevention research, he says he's well aware of the scientific evidence that points to tea and coffee doing the body good.

They each "contain different types of polyphenols (micronutrients from plant-based food), but they all activate our body's key health defense systems (starving cancer, feeding our healthy gut bacteria, repairing damaged DNA, improving immunity) that help us resist cancer. From lab studies to clinical trials to large-scale public health studies showing that tea or coffee lowers risk across different forms of cancers, I consider it a no-brainer to drink these beverages." And it's a cherry on top that he loves the taste!

The lead authors of a large-scale study from the University of Glasgow in 2018 now know it's best to keep screentime to a minimum. They analyzed nearly 400,000 people and found a strong correlation between higher screentime and a higher risk of all-cause mortality, cardiovascular disease, and cancer. This was independent of known cancer-causing factors like smoking, BMI, and diet.

The more discretionary, or leisure, time spent on tablets, smartphones, and other media devices directly contributes to a sedentary lifestyle, the result of which is lower physical fitness, grip strength, and overall poor health.

RELATED: I'm A Doctor And Warn You Never Take This Supplement

Nearly half the deaths from an astounding 12 different cancers can be attributed to smoking cigarettes: liver, colorectal, lung, oral and throat, esophageal, larynx, stomach, pancreas, bladder, kidney, cervix, and acute myeloid leukemia. That's why it's a smoke-free life for Dr. Wafik El-Deiry, Associate Dean for Oncologic Sciences at Brown University. While fewer people smoke in 2019, plenty are still addicted to one of the single-most unhealthy habits.

He does note that quitting smoking can have a positive impact, but that the risk never fully goes away compared to the general population. It can take 8-10 years to truly minimize the risks associated with cigarette smoking.

Likewise, Dr. El-Deiry isn't vaping, either.

"The message needs to get out that [vaping] is potentially cancer causing and we have to be aware," he warns. "The more we talk about itto save anyoneis worth it."

He says the more we learn about vaping the more we realize how unsafe it is in different ways. The vapor exposes users to chemicals known to cause cancer, for instance. And while e-cigs have their place for smokers trying to quit, the vape pens aren't benign. El-Deiry reminds that no substantial research has yet been completed on the relationship between vaping and cancer.

The National Institutes of Health warns that teens are vaping in record numbers; higher than opioid or marijuana use.

Dr. Katherine Crew, director of the Clinical Breast Cancer Prevention Program at New York-Presbyterian and Columbia University Medical Center, walks at least a mile every day. "For a busy oncologist, it's not always easy to find time to lead a healthy, active lifestyle, but I try to incorporate it into my daily routine."

Each of those steps is worth the time. Walking a single mile each day at a moderate 20-minute pace can reduce mortality in breast cancer patients by as much as 40% and almost 30% in prostate cancer patients. Risk for endometrial cancer is also reduced by a moderate intensity walking regimen.

Dr. Crew also takes the stairs "whenever it's humanly possible" to gain an extra burst of physical activity in her day.

RELATED: 9 Everyday Habits That Might Lead to Dementia, Say Experts

As an exercise oncologist, Kathryn Schmitz, PhD gets as much movement as she recommends. Before heading outdoors though, "I slap on the sunscreen, since exercise increases the risk of melanoma by 28%." While this 2016 study found that exercise reduces the risk for 10 different cancers, it increased risk for malignant melanoma significantly.

Schmitz echoed the researchers' assumption that increased time exercising or enjoying leisure physical activity increased exposure to the sun, which in turn increased the incidence of skin cancer. If you're spending time outside, be sure to wear a broad spectrum sunblock with SPF 30 or higher and remember that "water resistant" is not the same as "waterproof."

Making "greener" choices can ultimately support everyone's goal to reduce their risk of cancer. Climate change is having a negative impact on more than just the earth's health and sustainability. Human life is taking a negative toll, too.

Stratospheric ozone depletion is implicated in an increase in skin cancer incidence, like melanoma, and scientists expect to see a continuation over the next couple of decades.Exposure to air pollution increases the risk of breast cancer in premenopausal women. And the very air we breathe has been deemed carcinogenic by WHO, citing a direct correlation to nearly a quarter-million lung cancer deaths in 2010 alone.

How much "good" fat do you have in your diet? It's something Dr. Stephen C Schimpff, MD, MACP, author of Longevity Decoded The 7 Keys to Healthy Aging, prioritizes in his own diet. He recommends avocado, nuts and seeds, olive oil, and fish like tuna and salmon.

What makes a fat good for you? These unsaturated fats remaining liquid, not solid, at room temperature and are generally derived from plants.

Tree nuts like almonds, walnuts, and pecans can decrease your risk of colon cancer, which is why Kevin Dawravoo, MD, hematologist and medical oncologist at Northwestern Medicine Cancer Center Warrenville, makes them a regular part of his diet.

For men and women, a 2018 study found a "statistically significant" link between eating nuts three times per week and a reduction in colorectal cancer risk.

Another 2018 study found that stage 3 colon cancer patients who had two 1-ounce servings of tree nuts (which included walnuts, cashews, almonds, pistachios, hazelnuts, pecans macadamia nuts, and Brazil nuts) each week were 42% more likely to experience disease-free survival and 57% greater chance of overall survival.

Turn up the flavor experience of roasted vegetables, rice, soup, smoothies, and tea by adding turmeric. This Indian spice, most common in curries, has an earthy sweet-pungent flavor and bright orange hue that can truly transform any food. That, and the cancer-preventative benefits, are why Roshni Rao, MD, Chief of the Division of Breast Surgery at New-York Presbyterian Hospital and Columbia University Medical Center, loves to eat turmeric-laden foods.

"Most of the studies do show a benefit from this anti-inflammatory, and there is no study that shows that it is detrimental," she says.

A 2015 study reviewed the multifaceted role of curcumin (the source of turmeric) in cancer prevention, and found that it can "suppress initiation, progression, and metastasis of a variety of tumors."

The plastics we brush our teeth with, eat and drink from, build toys with, type on, and so much more inundate every aspect of our lives, but the chemicals within are taking away our health and mortality. Especially when plastics are heated or scratched, they can leach the chemicals used to develop the products. Once inside our bodies, these chemicals, like BPA, disrupt the natural role of hormones and create an imbalance that can ultimately lead to cancer.

"BPA has been shown to play a role in the [development of]hormone-dependent tumors such as breast and prostate cancer," states a 2015 study that reviewed the health risks associated with exposure to bisphenol A.

Avoid plastics whenever possible by looking for BPA-free products and carrying reusable glass or steel drinking vessels. Do not cook or reheat food nor store hot food in plastic containers.

"Especially important in the summertime is decreasing charred food consumption," says Kevin Dawravoo, MD of Northwestern Medicine Cancer Center Warrenville. Reminding that the blackened char marks on grilled meat is a known carcinogen. It's something he rarely eats.

The concern is that when meat is cooked over open flame, and burned or blackened, chemicals known as HCAs and PAHs develop. When consumed these can alter a person's DNA which increases the risk of cancer.

In rodent studies, HCAs developed tumors breast, colon, liver, skin, lung, prostate, and other tumors. Similar rodent studies found that PAHs caused leukemia, and identified gastrointestinal and lung tumors. In epidemiologic studies, higher consumption of well-done and "barbecued" meat was linked to increased risk of colorectal, pancreatic, and prostate cancers.

RELATED: Everyday Habits That Make You Look Older, According to Science

You might be bored answering all of your doctor's questions about your parents' and grandparents' health, but it truly matters. Dr. Wafik El-Deiry, Associate Dean for Oncologic Sciences at Brown University, knows his family history and strongly recommends that you do the same.

"Illnesses that are found in the family can be a major clue to what risks there are," he says, adding that a history of cancer is usually well known and not difficult to learn about.

Sharing your family history with your doctor means they can do additional screening sooner, and work to catch symptoms and tumors earlier, which is key in treating and curing cancer.

"This knowledge may also direct patients to genetic testing that can further help to figure out different options to manage the risks," he added.

"Read your mammography results letter. In many states, including Connecticut, we, as radiologists are required to inform the patient whether or not her breast tissue is dense. If your breast tissue is dense, talk to your doctor about whether you need additional tests: a screening ultrasound or possibly even a screening MRI, the latter being a useful complementary screening tool in some women at higher than average risk of developing breast cancer. Please note that screening ultrasounds and screening MRIs do not replace mammography; rather, they are a complement to it," says Liva Andrejeva-Wright, MD, a Yale Medicine radiologist who specializes in breast imaging.

"It is important to know that screening mammograms do not prevent breast cancer. They do help by detecting cancer early in many cases, before it becomes palpable, however, and therefore prevent disease and treatment related morbidity that would have occurred if the cancer was detected later by the patient or her doctor," she added. And to get through this pandemic without catching coronavirus, don't miss this essential list: Most COVID Patients Did This Before Getting Sick.

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Slash Your Cancer Risk in Seconds, Say Cancer Experts | Eat This Not That - Eat This, Not That

Simple Ways to Never Age, According to Experts | Eat This Not That – Eat This, Not That

Living to be 100 used to be a novelty, so much so that Willard Scott, the Today Show weatherman, would announce your name on air in awe (Al Roker still does). Yet, these days it's not so uncommon to live that long. We're all living longer than ever. The Centers for Disease Control and Prevention currently pegs 78 years of age as the average life expectancy. That's not too shabby considering a century ago people lived to be around 39 (due to an influenza outbreak).

But what if we could push it 25 years more?

Worldwide, there are nearly 500,000 people who have made, or surpassed, the 100-mark, and this number is projected to grow to 3.7 million by 2050. Here, Eat This, Not That! Health rounds-up the latest research that'll not only help you to live to be triple digits, but ensure you're happy doing so. Read onand to ensure your health and the health of others, don't miss these 19 Ways You're Ruining Your Body, Say Health Experts.

Don't down a bottle of Jgermeister in hopes of a long life ahead. But a glass of red wine, by all means. "Our research shows that light-to-moderate drinking might have some protective effects against cardiovascular disease," says Bo Xi, MD, associate professor at the Shandong University School of Public Health in China and the lead author of a study published in the Journal of the American College of Cardiology, "while heavy drinking can lead to death. A delicate balance exists between the beneficial and detrimental."

The Rx: Red wine contains antioxidants, can lower cholesterol, reduces the risk of stroke and increases bone density. Enjoy one to two glasses a day if you wish.

Eating meat less than once a week may increase longevity by 3.6 years, according to a study published in the American Journal of Nutrition. Another 22-year study out of Finland found increased mortality and disease among individuals with higher animal protein intakes.

The Rx: If you must eat meat, opt for leaner proteins (chicken, turkey, lean cuts of beef) and keep off the bacon and sausages since diets heavy in processed meats are linked to higher risk of cancer and heart disease. Otherwise, explore the exciting new world of plant-based nutrition, with a product like Beyond Meat, made with pea protein.

Be mindful of your surroundings, and what you're breathing in. Everything from Benzene (found in gasoline), smoke, and other toxins can lead to cell degeneration and increase mortality rates, studies show.

The Rx: Don't miss this essential list of 100 Ways Your Home Could be Making You Sick.

Olive oil, veggies, fruits, nuts, seafood and a moderate amount of wine and cheesewe've all heard the Mediterranean diet is the secret to a longer life. In fact, numerous studies have linked the diet to improving brain health and function, lower risk of cancer and other diseases.

The Rx: Now it's time you tried it. Eat almonds, hummus, wild salmon, garlic, lemon, quinoa, cauliflower, chia seeds and olives frequently. Eat eggs, Skyr, and chicken moderately. And eat red meat rarely. Avoid entirely the packaged, processed, store-bought items that are loaded with additives.

RELATED: 9 Everyday Habits That Might Lead to Dementia, Say Experts

Gene variants found in centenarians have been linked to their longer lives. A healthy lifestyle can help people live into old age, but these genes help maintain basic maintenance and function of the body's cells in individuals of advanced age, in their 80s and beyond.

The Rx: You can't outrun genetics but you can learn about yours. Consider taking a DNA test, in which you'll learn about your proclivity to certain diseases.

Japan is doing something right! It currently holds the title of longest life span, according to the World Health Organization. This may have something to do with the size of their plates. When it comes to diet, the Japanese tend to eat smaller portionsspecifically the size of a salad plateand don't overstuff themselves. Centenarians studied in Okinawa stop eating when they are 80 percent full. They also tend to live seven years longer than Americans, according to a study, and have fewer cases of heart disease and cancer.

The Rx: Experiment with the 80% rule. Or at the very least, don't keep eating when you feel full.

Don't work so hard; your life depends on it. A Finnish study followed male businessman born between 1919 and 1934, and found that those who didn't sleep enough, were overworked, and didn't take enough time off (i.e. vacation) were 37 percent more likely to die between the years of 1974 and 2004. By 2015, some of the oldest participants, who always took their vacay, reached 81 to 96 years of age.

The Rx: Our current culture rewards non-stop go-and-do work. But at what cost? If you have vacation days, use them to unplug, and be firm with your boss if you must. He'll value your work more if you're alive than dead.

RELATED: The #1 Reason You Could Get Cancer, According to Science

Each hour you binge Netflix, Hulu, HBOthe list goes onafter the age of 25 may cut your life by 22 minutes, according to research out of the University of Queensland, Australia. Those who spent an average of six hours in front of the tube per day were also likely to die five years earlier than those that didn't watch TV at all.

The Rx: There are other reasons to stop clicking "next episode." They can be addictive and eat up your time. (Robert De Niro is currently suing an ex-employee because he watched 55 episodes of Friends in a row.) Enjoy your One Day at a Timeone episode at a time.

A study out of the University of Naples found that too little or too much sleepsleeping less or more than six to eight hours on averageis linked to a 30 percent higher chance of premature death.

The Rx: Seven to eight hours of shuteye is the sweet spot.

RELATED: This Supplement Can Raise Your Heart Attack Risk, Experts Say

Packed with vitamin C and other nutrients, studies have found mustards, also known as Brassicaceae, will keep you around longer, according to researchers.

The Rx: Enojy cabbage, broccoli, cauliflower, kale, radishes, watercress, Brussels sprouts and a few spices like horseradish, wasabi and, yes, white, Indian and black mustard.

Hey, none of us are getting out of this alive, but that's no reason to keep that sour mug. Researchers examined smile intensity among photos of baseball players from the 1950s. Of the players who had died in the years 2006 to 2009, those who were not smiling in those photos lived an average of 72.9 years, while the big smilers lived nearly 80 years. They concluded that there's a clear link between smiling intensity and longevity.

The Rx: Men, stop telling women to smile. It's demeaning and implies they're subservient. However, given the impact on our health (mental and otherwise), we could all stand to turn that frown upside down.

Old dogs can't learn new tricks but you can. Education, coupled with a healthy weight, leads to a longer life expectancy, revealed a study out of the University of Edinburgh, with almost a year added to your life for each year spent studying beyond school.

The Rx: Pull a Dangerfield and go back to schooleven if it's just an herbalism course, knitting class or continuing ed program.

RELATED: I'm A Doctor And Warn You Never Take This Supplement

Avoid certain jobs, some of the deadliest out there, according to the Bureau of Labor Statistics National Census of Fatal Occupational Injuries, if you want to stick around longer. On the flip side, find a job you love. You'll be happier, longer, which can impact you positively long-term.

The Rx: Truck driver, farmers and construction laborers are among the most dangerous, mainly owing to vehicular accidents.

Country life is serene, but the Milken Institute Center for the Future of Aging found that living in a major city can also support longer life spans because of stronger health systems, and more access to learning, arts, culture, and other healthy stimulants.

The Rx: Eat This, Not That! Health is based in New York City and our editors can attest living here indeed makes you feel young, although struggling to afford it might age you. Weigh the fantasy versus reality before any leaps.

Good relationships, more than money or fame, are what keep people happy throughout their lives, a Harvard study revealed. Another study in Personal Relationships looked at 270,000 people in nearly 100 countries with a strong link to better health in older age among those with strong friend and family connections.

The Rx: Send a "friend request" to someone you'd like to be closer toand meet them in person, not just online.

Compared with persons with a normal body mass index (18.5 to 25), those who are underweight, overweight, and obese have an increased risk of death over a 30-year period. Being too underweight, or at the extreme, obese, can impact health significantly over time, show studies.

The Rx: A book like Zero Belly Diet can help you cut dairy, reduce bloat, stay plant-based and be leaner for life.

Stay away from men. That's what centenarian Jessie Gallan, at one time Scotland's oldest woman, credited for her longevity. "They're more trouble than they're worth," she said in an interview before her death in 2015. Granted, Gallan was a tough woman without or without a man. She started working at the age of 13 and spent her 109 years staying fit and having good people in her life but never walked down the aisle.

The Rx: There's no definitive research supporting a link between marriage and longevity one way or the other, although one study found that "current marriage is associated with longer survival. Among the not married categories, having never been married was the strongest predictor of premature mortality." Our advice: Marry the person you want to spend your life with, and give one another room to grow.

If you want to live longer, make sure you and your spouse are happy. A study published by the Association for Psychological Science found that a happy marriage can lead to a longer life.

The Rx: A good marriage is linked to a more active life and healthier habits, overall. How's your relationship?

RELATED: The #1 Cause of Obesity, According to Science

As stressful as parenthood gets at times, having kids can actually keep you around longer since it encourages a healthier lifestyleyou're more likely to give up smoking and stay active, shows one study.

The Rx: Don't have children just to live longer. But if you do have or want kids, remember that your habits become theirs. Set the example.

Keep a good pace. Brisk walking will keep your heart healthy and add some years to your life, according to a recent Mayo Clinic study. Researchers reported that women who walked more quickly had a life span of about 87 years compared to 72 years for women who walked slowly. Meanwhile, men who walked quickly had a life span of about 86 years compared to 65 years for men who walked more slowly.

The Rx: "Walking is man's best medicine," said Hippocrates. Get steppin'.

A handful of nuts a day may keep the doctor away, according to Harvard University research, which found that people who crunch some nuts daily lived 20 percent longer than those who didn't.

The Rx: Our favorite is almonds. Besides being an easy go-to snack that you can whip out of your bag during a good ol' 9-5 shift, almonds are also chock-full of essential vitamins and minerals, with vitamin E and biotin being the most predominant. Those nutrients enable your skin to remain smooth and gives your lush hair and strong nails the nutrition they need to flourish.

Don't stopever! The moment you become stagnant, things may go downhill. Stay active. A 2016 study found that elderly people who exercised for just 15 minutes a day, at an intensity level of a brisk walk, had a 22 percent lower risk of early death compared to people who don't exercise.

The Rx: "For most healthy adults, the Department of Health and Human Services recommends these exercise guidelines: Get at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous aerobic activity a week, or a combination of moderate and vigorous activity," reports the Mayo Clinic.

To quote Dr. Nelly of Nellyville: It's getting hot in here. Frequent spicy food consumption is linked to a longer life. Those who eat spicy foods nearly every day have a 14 percent chance of living longer, according to a Harvard study. Capsaicin and other compounds in chili peppers have been linked to fighting cancer, obesity, and more.

The Rx: Sprinkle some cayenne pepper into your eggs every morning, for a one-two punch of protein and spice.

RELATED: Signs You're Getting One of the "Most Deadly" Cancers.

Researchers at the Carleton University in Canada say that having a sense of purpose may add more years to your life, because of positive relations and emotions and overall well-being.

The Rx: Start small. Rather than ask yourself, "Why am I here? What is my place in the Universe" ask yourself, "What can I do today that will make me feel like I've enriched my life, or the lives of others?"

Yoga can help improve digestion, calm the nervous system, lower blood sugar, and so many other tangible benefits. It's no wonder researchers say it will help increase your overall life span.

The Rx: Get your chaturanga on! There's no doubt a yoga studio near you, with teachers who will welcome first-timers. For long-timers, consider a retreat.

Taking care of your teeth and gums isn't just about preventing cavities or bad breath. The mouth is the gateway to the body's overall health. Not flossing allows plaque to build up, which then turns into tartar that can eventually irritate the gums, which can lead to various infections and disease over time. Researchers followed more than 5,400 people for 18 years and found that those who did not brush their teeth daily had a 22 to 65 percent greater risk of dementia than those who brushed three times a day.

The Rx: The American Dental Association recommends brushing your teeth twice a day. Use fluoride toothpaste, and brush for two minutes.

Coffee is packed with tons of healthy compounds, including antioxidants, which can protect the body against cellular damage that can lead to disease, studies show.

The Rx: Drinking four to five cups daily is also associated with a reduced risk of early death.

This one is pretty self explanatory. An active lifestyle will keep you around longer. Exercising at a moderate level for at least 150 minutes can add on 3.4 years to your life, according to the National Institute of Health.

The Rx: Try one of these 25 Easy Exercises That Boost Your Health Fast. They really work.

Helping others can only make you feel good, and it helps boost overall mental health throughout time, which impacts the body's immunity to fight disease, according to a study published in BMC Public Health.

The Rx: Animal rescue shelters, national parks, Habitat for Humanity, local libraries, political campaigns and the YMCA are a few places that rarely say no to help.

RELATED: Sure Signs You Had COVID and Didn't Know It

Studies show sex releases endorphins and hormones in the body, which can help combat feelings of loneliness and depression, keep you physically active, reduce stress relieving, and boost mental wellness.

The Rx: Take this advice seriously. Having sex is one of theSimplest Ways to Avoid a Heart Attack, Say Doctors.

Are there stairs nearby? Good. Use them. The European Society of Cardiology released a study showing how brisk movement, particularly being able to climb three flights quickly, can reduce your risk of early death from cardiovascular and oncologic, and other diseases.

The Rx: Skip the elevators and escalators, and track your steps with a fitness watch, if you need more motivation.

The sweet stuff won't get you far in lifeliterally. Too much sugar is linked to shorter life spans, according to one study. Sugar has even been linked to reprogramming how our genes function. The Centers for Disease Control and Prevention (CDC) reports that about 14% of the daily calories the average Ameican consumes comes from added sugars. And it shows. According to a Population Health Management publication, the number of Americans diagnosed with diabetes increased more than three times between 1990 and 2010. This just so happens to be the same years sugar starting becoming more prevalent in our food.

The Rx: A book like Sugar Free 3 can teach you how to identify added sugarsand how to give them up.

Get in touch with your spiritual side. People who attend religious services, or have some spiritual connection, typically experience lower levels of anxiety, depression, have lower blood pressure, and are generally in better health. An 18-year study published in PLOS One found that regular service attendance was linked to reductions in the body's stress responses, and worshippers were 55 percent less likely to die.

The Rx: You read that right: 55 percent less likely to die. Start by defining what spirituality means to you, and then see if there's a community that supports that common interest.

If you're not connected to a particular religion, you can still find your spiritual balance through meditation. Not only does it improve mental health, but meditating has been linked to a lower risk of cancer and other diseases, according to a study from the University of California-Davis, which found that regular meditation produces higher levels of telomerase, an enzyme that helps lengthen the telomeres in our chromosomes, which impact aging.

The Rx: Apps like Insight Timer, Headspace and Calm have taken meditating mainstream; try one. One of our favorite apps is 10% Happier, from ABC News man-turned-meditator Dan Harris.

If you know how to laugh at things, you'll live longer. A 15-year study out of Norway assessed the link between a sense of humor and mortality rates among 53,556 men and women and found that women who had a good sense of humor lived longer, despite illnesses, including cardiovascular disease; cheerful men faired just as well with laughter protecting them from infection.

The Rx: We've been obsessed with the funniest lines from HBO's Successionand aren't even sure it's a comedy!

RELATED: Everyday Habits That Make You Look Older, According to Science

Want to live to 85 or longer? Optimistic thinking can add years on to your life, say researchers at Boston University School of Medicine. Optimistic people can better regulate emotions so we can bounce back from stressors and difficulties more effectively.

The Rx: Technically, the glass is always half full. The other half is air.

Creativity keeps the brain healthy and may decrease mortality rates. Researchers agree. Creative people just tend to live longer.

The Rx: Remember this, if something's blocking you: You don't have to be "creative" to create.

Be good to yourself. Self compassion goes a long way, say researchers. It's associated with better moods, can improve body image, and is linked to happiness, optimism, wisdom, personal initiative, and more. Overall, it improves our entire mental health, which keeps our body more resilient to stress and illnesses.

The Rx: Did we mention we love that thing you said today? So smart! So funny! So wise.

People who eat fiber-rich foods, including some good 'ole oatmeal or porridge, cut their risk of dying from cardiovascular, infectious, and respiratory diseases by 24 to 56 percent in men and by 34 percent to 59 percent in women, shows one study.

The Rx: Buy "regular" oatmeal and add berries for sweetness. Anything else may be loaded with dangerous added sugars.

Owning a dog is linked to a longer life, according to researchers out of Uppsala University in Sweden, who reviewed national registry records of 3.4. million men and women, ages 40 to 80.

If you're a cat person, you'll get some extra years from kitties as well. A study by the Minnesota Stroke Institute found that people who owned cats were 30 percent less likely to suffer a heart attack.

The Rx: We mentioned volunteering at the ASPCA. If you feel truly capable of caring for a pet, discuss taking one home. We like these questions from Nylabone:

Get back to basics with food. Those who incorporate more whole grains, vegetables, fruits, and fish and limiting too much sodium, unhealthy fats, excess red meat, sugar, and processed foods, improved their overall health and life expectancy.

The Rx: For the web's #1 nutrition resource, and to make the right food choice every time, head to Eat This, Not That!

Does longevity run in your family? Dig deeper into your family history, including lifestyle habits, illnesses, deaths, and beyond. It may help us tap into how long we ultimately have here.

The Rx: Put together a family treewith dates of birth, death, and causes.

Tea contains flavonoids, a compound that works to boost health. One study found that 88 percent of women were 40 percent more likely to live longer because they drank two cups of tea per day.

The Rx: Go green. The most potent catechin in green tea is EGCG, the powerhouse compound that's responsible for most of green tea's weight loss properties. In addition to revving your metabolism and boosting the breakdown of fat, EGCG can also block the formation of new fat cells.

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Simple Ways to Never Age, According to Experts | Eat This Not That - Eat This, Not That

What is biochemistry? – Biochemistry

Biochemistry is the branch of science that explores the chemical processes within and related to living organisms. It is a laboratory based science that brings together biology and chemistry. By using chemical knowledge and techniques, biochemists can understand and solve biological problems.

Biochemistry focuses on processes happening at a molecular level. It focuses on whats happening inside our cells, studying components like proteins, lipids and organelles. It also looks at how cells communicate with each other, for example during growth or fighting illness. Biochemists need to understand how the structure of a molecule relates to its function, allowing them to predict how molecules will interact.

Biochemistry covers a range of scientific disciplines, including genetics, microbiology, forensics, plant science and medicine. Because of its breadth, biochemistry is very important and advances in this field of science over the past 100 years have been staggering. Its a very exciting time to be part of this fascinating area of study.

To find out more about careers in biochemistry read our bookletsBiochemistry: the careers guideandNext Steps.

The life science community is a fast-paced, interactive network with global career opportunities at all levels. The Government recognizes the potential that developments in biochemistry and the life sciences have for contributing to national prosperity and for improving the quality of life of the population. Funding for research in these areas has been increasing dramatically in most countries, and the biotechnology industry is expanding rapidly.

The Biochemical Societyaims to inspire and engage people in the molecular biosciences. We offer study and careers advice toschool students,higher education studentsandteachersas well as carrying outpublic engagementevents.

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What is biochemistry? - Biochemistry

Biochemistry: Free For All – Open Textbook Library

Reviewed by Jeffry Nichols, Associate Professor, Worcester State University on 6/1/21

Comprehensivenessrating:3see less

The material covered is fairly similar to other biochemistry textbooks, but does lack some of the details of a more comprehensive biochemistry text (i.e. Lehninger's text). This isn't a negative, just an observation. The order in which the concepts are presented is different, but again still fairly complete.

Content Accuracyrating:4

From what I could tell, the information is accurate. Examples appear to be unbiased and give good everyday correlations to biochemistry ideas.

Relevance/Longevityrating:3

The material for the basics and background for biochemistry are unlikely to change, so in that sense they are relevant. The way in which the material is presented, i.e. the formatting, does make it difficult to follow at times. The tables and figures are not always near the relevant text and often there are figures/tables that appear before the section in the text. Again, this could be a formatting issue.

Clarityrating:4

The text is easy to follow, avoids jargon for the most part (until it needs defining). As mentioned above, references to tables/figures are hard to follow and some tables/figures seem "stuck in" at random points. This hurts the clarity of the text while reading.

Consistencyrating:4

Each chapter sticks to a familiar layout and walks the student through the various topics in a coherent manner.

Modularityrating:3

Overall the text could be broken up, but again, possibly due to formatting, many of the links do not work, interrupting the flow, On all the end of chapter sections, I couldn't get any of the links to work, with a message about "to be developed" or "coming soon". This is unfortunate as these links could be great for further exploration and follow up assignments.

Organization/Structure/Flowrating:3

Yes, the organization is pretty good, although I think the introduction of electron transport and electrochemistry should come after an understanding of WHERE these molecules are coming from, i.e. metabolism, breakdown of sugars, fats, amino acids, etc. This doesn't make it "bad", just no my personal preference. And as mentioned previously, the plethora of tables/figures can be overwhelming when they don't always line up with the discussion of them in the text.

Interfacerating:2

Couldn't get the links to work--although it appears many of the links are "printed" after the end of entire book. So the material might be there, but as it is currently put together, it would be difficult for instructors or students to use these links effectively.

Grammatical Errorsrating:4

From what I can tell, the grammar is fine throughout the text.

Cultural Relevancerating:4

Again, from what I read, I didn't notice any insensitive or offensive parts. Examples were clear and highlighted the biochemical aspects without a need address social or other issues. (which could actually be good depending on the nature of the class and student's interest in how science touch many aspects of our lives)

I have hope for this book, but I couldn't readily tell if this book is being maintained or updated on a regular basis, or if it is just a framework for others to build upon. The organization isn't ideal, and there are problems with links and such, but the overall material and coverage looks pretty good.

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Biochemistry: Free For All - Open Textbook Library

Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. – Physician’s Weekly

Irritable bowel syndrome (IBS) is known as one of the most common irritating gastrointestinal disorders. The mechanism behind IBS is still under investigation and it is thought that it may arose from multi factors among which free radicals have been previously mentioned. Studies have found an association between oxidative stress and IBS; however, little is known about the mechanisms and oxidative stress components status during IBS. One of the key factors playing a central role in oxidative stress network is glutathione reductase (GR). Here we report the GR activity in colon tissue samples during IBS to explore a part of contributing components in IBS pathogenesis.The GR enzyme activity was measured in 15active IBS colon biopsy samples and was compared to our best available age and sex matched colorectal tissue samples from normal marginal tissue of resected colon cancers (n=15). The enzyme activity in the two groups was determined and compared using a commercial GR Assay Kit (Cayman chemical).A significant decrease in GR activity among IBS tissue samples was observed compared to anatomically normal marginal colon tissue samples (p=0.007).Lower GR activity may increase oxidized glutathione there by in turn could contribute as a main component in oxidative stress network. The lower GR activity results in hampered defense mechanism against produced free radical species. This finding may clarify a part of IBS pathogenesis. 2021 Walter de Gruyter GmbH, Berlin/Boston.References

PubMed

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Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. - Physician's Weekly

ETSU research leads the way in study to increase diversity of heart-healthy plant oils – Johnson City Press (subscription)

Dr. Aruna Kilaru, associate professor of biological sciences at East Tennessee State University, and her research team have been working on a new way to combat cardiovascular disease as Americans leading cause of death by studying how to produce more good, monounsaturated fats found in plant oils, often used in cooking, and how to make them more abundant for future generations by using plants that are otherwise genetically deficient.

Saturated fats, or animals fats, increase bad cholesterol, leading to clogging of arteries. Replacing that diet with monounsaturated oils will decrease the risk of heart diseases, said Dr. Kilaru. As such, among various oils, monounsaturated oils such as those in olive and avocado fruits are considered to be heart-healthy.

Saturation refers to the lack of any double bonds in the fatty acid chain while unsaturation refers to the number of double bonds present; a single double bond is referred to monounsaturated and many as polyunsaturated.

Dr. Kilaru noted humans and other mammals lack some of the enzymes necessary to add initial double bonds to fatty acids, making plant oils a critical source of healthy oils. When consumed, these can be converted into other polyunsaturated fatty acids necessary to regulate health and development.

Vegetable oil accounts for 25 percent of human dietary calories and its demand is expected to double by 2030. Increasing production of nutritionally rich oils has become a necessity, added Kilaru.

Having already identified a regulator they believe to be responsible for high amounts of oil in avocado, Dr. Kilaru said ETSU research has made quite a bit of progress in understanding this oil biosynthesis. Now, thanks in part to funds from a recent $200,000 grant from the U.S. Department of Agriculture, the work will continue.

We have already identified one regulator that is likely responsible for high amounts of oil in avocado, said Kilaru. This funding will support continued research on the project by one of our Ph.D. students, Jyoti Behera, for two years and also the research expenses associated with further characterization of the mechanisms by which this novel regulator functions.

Plant oils, mostly stored in plant tissues as triacylglycerols, are not only an important source for human and animal nutrition, but also play important roles in the oil industry and renewable energy sources.

Added Kilaru, There is great diversity in plants tissues with regard to how much and what kind of oil they can synthesize and store. Although biochemists understand how storage oils are made, we do not fully understand what genes are responsible for dictating the content and composition in oil in plants.

Kilaru said her interest in this area of lipid biochemistry research was formed during her postdoctoral work.

I was fascinated by the diverse amounts and types of oils various plant tissues can make. For example, oil palm fruit stores its sugars from photosynthesis in the form of about 90 percent oil in the fleshy part of the fruit while its sister plant, date palm, reserves its energy as 90 percent sugar. I found these distinct abilities of plants both puzzling and fascinating. This work initiated at Michigan State University led to my further interest in using avocado as a system to understand its ability to make high amounts of monounsaturated oleic acid.

She points not only to avocados but also olives. Both synthesize and store heart-healthy, nutritionally rich monounsaturated oils, the good fats, at approximately 60-70 percent in their fleshy fruit but with negligible amounts in their seeds. Palm oil, on the other hand, contains 80 percent saturated fat in its seeds while the fleshy fruit contains only approximately 50 percent saturated oil.

In our lab, we are using avocado as a model system to identify the key regulators of oil content and composition, said Kilaru. Once we identify these key regulators and fully understand their mechanisms, we expect to utilize them to enhance production of nutritionally rich oil in other plants, as well, for human consumption.

The end result of the research could mean a healthier global population.

For more information on the research project, contact Dr. Kilaru at kilaru@etsu.edu or 423-439-5601. More information on the ETSU Department of Biological Sciences can be found at etsu.edu/cas/biology.

Contributed to the Press

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ETSU research leads the way in study to increase diversity of heart-healthy plant oils - Johnson City Press (subscription)

biochemical diagnostic reagent Market Report Examines Business Opportunity and Worldwide Scope by Forecast 2021 to 2026 The Courier – The Courier

A new report titled, Global biochemical diagnostic reagent Market has been added into its vast repository by Straits Research. The report analyzes and estimates the biochemical diagnostic reagent market on a global, regional, and country level. The report offers data of previous years along with an in-depth analysis from 2017 to 2022 on the basis of revenue (USD Billion). Besides, the report offers a comprehensive analysis about the factors driving and restraining the growth of the market coupled with the impact they have on the demand over the forecast period. In addition, the report includes the study of lucrative opportunities available in the biochemical diagnostic reagent market on a global level.

To get SAMPLE of the report, please click:https://marketstrides.com/request-sample/biochemical diagnostic reagent

TheMajorPlayers Covered in this Report:RocheBeijing Strong BiotechnologiesRandoxSiemens HealthineersFosunPharmaBeckman CoulterSysmexBeijing Leadman BiochemistryBioSinoDojindo LaboratoriesKAINOS LaboratoriesDAAN Gene

The report on the Global biochemical diagnostic reagent Market offers data of previous years along with in-depth analysis from 2021 to 2027 on the basis of revenue (USD Billion). Besides, the report offers a comprehensive analysis of the factors driving and restraining the growth of the market coupled with the impact they have on the demand over the forecast period.

biochemical diagnostic reagent Market By Types

Liquid Double ReagentDry Powder Double Reagent

biochemical diagnostic reagent Market By Applications

HospitalClinicLaboratory

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This report forecasts revenue growth at the global, regional, and local levels and provides an analysis of the most recent industry trends from 2021 to 2027 in each of the segments and sub-segments. In addition, the report highlights the impact of COVID-19 on the Global biochemical diagnostic reagent Market and how the market is undertaking measures to reduce the losses. Some of the major geographies included in the market are given below:

Key Questions Answered in the Report:

Full Report:https://marketstrides.com/report/biochemical diagnostic reagent

RocheBeijing Strong BiotechnologiesRandoxSiemens HealthineersFosunPharmaBeckman CoulterSysmexBeijing Leadman BiochemistryBioSinoDojindo LaboratoriesKAINOS LaboratoriesDAAN Gene

And More

Contact UsCompany Name: Market StridesContact Person: Nikolai EggerCall: +1 856 677 8909 (US)Email: sales@marketstrides.com

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biochemical diagnostic reagent Market Report Examines Business Opportunity and Worldwide Scope by Forecast 2021 to 2026 The Courier - The Courier

Capturing the look and feel of Idaho’s backcountry in your backyard – East Idaho News

How to effectively capture the look and feel of Idahos backcountry in your backyard | Lance Ellis, EastIdahoNews.com

There is nothing as interesting and enjoyable as spending time in the forests or mountain areas in Idaho. Whether its the beauty, the quiet, the trees, the interesting rocks, the shade, the adventure, or any of the infinite reasons to go out and get away from the world; the backcountry of Idaho is an incredible place to enjoy.

Most jobs and locations arent conducive to having the time to get away after work, but with some planning, work and budgeting, you can create a backyard that has some of your favorite things from Idahos backcountry in your own yard.

To re-create the natural ecology of eastern Idaho, I would do the following things:

Living in the mountains, we have a wide variety of different kinds of rocks to choose from ranging from sandstone, river rocks, lava rocks, and many other kinds. The type of rock can add or detract from the style of the mountain landscape that you are trying to create.

Put your yard together the way that mother nature does, meaning dont plant trees or shrubs in straight lines and instead put natural curves into the layout of your yard. Use groupings of plants to make your yard more reflective of what you see in the mountains. Aspens for example never grow alone in the mountains, nor do they grow in a straight line. Trees in natural settings grow in large groupings or clusters, which is why we call them either an entire forest or a grove of trees. This way of landscaping can work well with urban settings as most people would like the privacy, screening, and shade that a grove of trees would provide.

Lance Ellis | EastIdahoNews.com

While water features and small ponds may look attractive, they are a lot of work, are expensive, and are a drowning hazard for children. More authentic to our area than an actual water feature is a dry creek bed since we live in a high-altitude desert, and dry creek beds are quite common. Putting in a dry creek bed is a great way to utilize a difficult area in your yard that may not have a specific purpose, and also saves on water since plants used in dry creek beds are normally drought-tolerant, deep-rooted, and low maintenance.

For further gardening ideas, reach out to Lance at (208) 624-3102.

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Capturing the look and feel of Idaho's backcountry in your backyard - East Idaho News

The Academy of Health Science Professions and STEM fully prepares Val and Sal for future medical field – Progresstimes

Valedictorian Amanda Salinas and Salutatorian Elizabeth Abila, both students from The Academy of Health Science Professions and STEM, will be graduating with their home school, Juarez Lincoln.Salinas has been chosen as 1 of 8 in the state of Texas to receive early admission into the physician assistant program. She will be graduating with her associate degree in biology from STC and 66 college credit hours.

Valedictorian Amanda Salinas, courtesy photo.

I had applied for the program this semester and went through an application process and got an interview at UTRGV, Salinas said. Im really glad that I was able to receive this amazing opportunity because this means that Ill have a secured spot on the masters program once I graduate with my bachelors from UTRGV. Having that spot will bring me one step closer to achieving my career goal of becoming a PA.Salinas has always dreamed of working in the medical field, and this past year opened her eyes and pushed her towards that goal even more.My school really focuses on showing their students the different careers in the medical field, Salinas said. And one of them was a PA. When I learned about being a PA, it really inspired me to want to become one. A recent experience that inspired me more was when my dad and sister got sick with COVID. That experience was terrifying for me because I was so worried about them and if they would get better or not. Thankfully because of my dads physician, they did fully recover. I want to do the same for other families and patients in the future.Despite the health scare in her family, Salinas had the support of her school when things got tough.The academy really shaped me into the person I am today because they always encouraged and supported me in my academics, Salinas said. They encouraged me to take rigorous courses and with the support of my high school I was able to apply to the dual enrollment medical science academy at STC. I was attending high school the first half of my day, and then I would attend STC the second half of my day. This really prepared me for college. Once I finish the program, Ill be going to graduate school at UTRGV as well.Salinas love for her family and her community shows in how hard she has worked to achieve valedictorian and pursue her goals.My family means so much to me, especially now, Salinas said. During the pandemic I learned so many lessons about what it means to be a family and I just really love spending time with them as much as I can. We may face challenges that scare us or try to stop us from accomplishing our goals. But in that case, you really have to persevere through those and make the best of the situation. I think weve all learned that from this past year.Salutatorian Elizabeth Abila has plans to attend Michigan State University and double major in Biochemistry and Molecular Biology.

Salutatorian Elizabeth Abila, courtesy image.

One of the main reasons I chose Michigan State was because I used to have a neighbor that went there, thats how I first heard of it, Abila said. And then I started researching more on the biochemistry program, because thats what I want to major in. They have one of the best in the nation so thats why I decided to apply there, and I got in.Abila credits her future career choice to her kindergarten teacher who went above and beyond for her when she had to miss school for some time.Ive always known that I wanted to be in the medical field since I was in kindergarten, Abila said. I broke my arm when I was in kindergarten and my teacher would always come to my house after school to teach me everything that she taught the class that day so that I wouldnt fail the school year. So that was one of my big influences that kept me going with getting good grades and everything.Abila has a love for children and the medical field and has done exceedingly well first at Juarez Lincoln, and now at the STEM Academy.

I want to be a pediatric heart surgeon, Abila said. My family is really proud of me, especially my mom. Shes telling the whole world.Although school can be tiring and tedious, especially for high achievers, Abila reminds her peers that its not worth it to give up or slack off.You should never give up, Abila said. Even if you feel like you might not get there or if you struggle along the way, at the end of the day, you just need to keep working towards your goals.

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The Academy of Health Science Professions and STEM fully prepares Val and Sal for future medical field - Progresstimes

Portable Veterinary Biochemistry Analyzer Market Global Demand, Research and Top Leading Player to 2026 Covid-19 Analysis KSU | The Sentinel…

Global Portable Veterinary Biochemistry Analyzer Market report provides information on types, applications and its regional markets including past and expected Opportunities. Portable Veterinary Biochemistry Analyzer Market report delivers data on Manufacturers, Geographical Regions, Types, Applications, Key Drivers, Challenges, Opportunities, Annual Growth Rate, Market Share, Revenue and the actual process of whole Portable Veterinary Biochemistry Analyzer industry.

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This report contains market size and forecasts of Portable Veterinary Biochemistry Analyzer in global, including the following market information:

Global Portable Veterinary Biochemistry Analyzer Market Revenue, 2016-2021, 2022-2027, ($ millions)

Global Portable Veterinary Biochemistry Analyzer Market Sales, 2016-2021, 2022-2027, (K Units)

Global top five Portable Veterinary Biochemistry Analyzer companies in 2020 (%)

The global Portable Veterinary Biochemistry Analyzer market was valued at xx million in 2020 and is projected to reach US$ xx million by 2027, at a CAGR of xx% during the forecast period.

MARKET MONITOR GLOBAL, INC (MMG) has surveyed the Portable Veterinary Biochemistry Analyzer manufacturers, suppliers, distributors and industry experts on this industry, involving the sales, revenue, demand, price change, product type, recent development and plan, industry trends, drivers, challenges, obstacles, and potential risks.

Total Market by Segment:

Global Portable Veterinary Biochemistry Analyzer Market, By Type, 2016-2021, 2022-2027 ($ Millions) & (K Units)

Global Portable Veterinary Biochemistry Analyzer Market Segment Percentages, By Type, 2020 (%)

Automatic

Semi-Automatic

Global Portable Veterinary Biochemistry Analyzer Market, By Application, 2016-2021, 2022-2027 ($ Millions) & (K Units)

Global Portable Veterinary Biochemistry Analyzer Market Segment Percentages, By Application, 2020 (%)

Veterinary Hospitals

Veterinary Clinics

Others

Global Portable Veterinary Biochemistry Analyzer Market, By Region and Country, 2016-2021, 2022-2027 ($ Millions) & (K Units)

Global Portable Veterinary Biochemistry Analyzer Market Segment Percentages, By Region and Country, 2020 (%)

North America

US

Canada

Mexico

Europe

Germany

France

U.K.

Italy

Russia

Nordic Countries

Benelux

Rest of Europe

Asia

China

Japan

South Korea

Southeast Asia

India

Rest of Asia

South America

Brazil

Argentina

Rest of South America

Middle East & Africa

Turkey

Israel

Saudi Arabia

UAE

Rest of Middle East & Africa

Competitor Analysis

The report also provides analysis of leading market participants including:

Key companies Portable Veterinary Biochemistry Analyzer revenues in global market, 2016-2021 (Estimated), ($ millions)

Key companies Portable Veterinary Biochemistry Analyzer revenues share in global market, 2020 (%)

Key companies Portable Veterinary Biochemistry Analyzer sales in global market, 2016-2021 (Estimated), (K Units)

Key companies Portable Veterinary Biochemistry Analyzer sales share in global market, 2020 (%)

Further, the report presents profiles of competitors in the market, key players include:

EKF Diagnostics

Samsung

Randox

Alphatecscientific

Genrui

KPM Analytics(AMS Alliance)

Woodleyequipment

Idexx

Zoetis(Abaxis)

Seamaty

YSENMED

MNCHIP

Full Report:

https://www.researchforetell.com/reports/66698/portable-veterinary-biochemistry-analyzer-marketglobal-outlook-and-forecast-2021-2027

Key Features of the Report:

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Portable Veterinary Biochemistry Analyzer Market Global Demand, Research and Top Leading Player to 2026 Covid-19 Analysis KSU | The Sentinel...

Bio-Based Itaconic Acid Market | Key Opportunities, Trends, Business Demand And Key Players Analysis | Itaconix Corporation, Qingdao Kehai…

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Bio-Based Itaconic Acid Market | Key Opportunities, Trends, Business Demand And Key Players Analysis | Itaconix Corporation, Qingdao Kehai...

SpaceX is causing division in Brownsville over disruption, economic impact – Business Insider

Residents of Brownsville, a small city in Texas, are divided.Their town is now home to SpaceX's rocket-production facilities, which only promises to grow bigger.

Some locals told Insider they're at their wits' end with SpaceX as the aerospace company sets off explosions and pushes locals out of the area. But others see it as a positive impact on the economy and residents' wellbeing.

Brownsville, which lies 20 miles west of SpaceX's launch facilities on the Gulf Coast, is known for being one of the poorest areas in the US. The 300,000-person city also has a very high unemployment rate.

When SpaceX CEO Elon Musk tweeted at the end of March that he was donating $30 million to Brownsville $20 million to schools and $10 million for revitalization it split the city.

Musk also announced that he was building a new city called Starbase at SpaceX's launch facilities which would be "much larger" than Boca Chica Village, where the company is developing its Starship rocket.

Brownsville's mayor Trey Mendez was surprised at Musk's announcement and said in an interview with KSAT 12 it was "exciting" that the community could have the chance to become the face of "space exploration and innovation."

Mendez said he hoped Musk's capital would help "accelerate the progress [in Brownsville] even more."

But there is division between those living in the south Texas city. Some are concerned that SpaceX's developments will be devastating for the people, nature, and ecosystems there. Others welcome the job opportunities, economic prosperity, and modernization that Musk's company could bring to the town.

SpaceX didn't immediately respond to Insider's request for comment.

Every time a rocket blows up on the launchpad, it hurls debris into the nearby nature sanctuaries in the area. SpaceX has witnessed four out of five of its Starship prototypes explode, meaning that metals and pieces of machinery are lying in areas that have never been disturbed before.

"These ecosystems are our community's lifeblood," said Bekah Hinojosa, resident of Brownsville and member of Another Gulf is Possible, an organization working on environmental issues along the southern Gulf Coast.

"SpaceX explosions are littering our ecosystems, home to the endangered ocelot, aplomado falcon, and numerous migratory birds," she said.

Xandra Trevio is a member of the art collective Las Imaginistas. It's an initiative that aims to connect with officials and lower-income residents in the Rio Grande Valley, where Brownsville is situated, to improve quality of life. As a resident, she told Insider that she's already seeing the negative effects of SpaceX in the area.

"Any SpaceX expansion would be occupying more land considered sacred to the local indigenous Carrizo Comecrudo tribe," Trevio said, who lives in the area.

Residents face disruption every time they're told to leave their homes before a SpaceX launch, she added.

In March, Musk encouraged people to move to the Brownsville area, saying that SpaceX needs specific jobs in engineering, tech, and other sectors.

Residents felt that Musk's Twitter callout, however, wasn't directed at them, but instead anyone in the US who wanted a career at SpaceX.

Claudia Michelle Serrano, a digital content coordinator for Las Imaginistas, who lives in Brownsville told Insider that Musk's job proposals via Twitter were offered on a national level to those interested in working for the space company.

"The jobs being created aren't for us," she said. "There is zero transparency on the jobs SpaceX created locally."

Jobs in Brownsville are low-wage, meaning that residents on those salaries won't be able to keep up with increasing costs in the city, according to Serrano.

Christine Leal, a 17-year-old high school student living in the Rio Grande Valley, told Insider that although her dream is to work for SpaceX after studying engineering at university, she's worried about "the immense danger," which the company will bring to the area.

Pulling in engineers from outside of the valley will lead residents to be financially disadvantaged and pushed out of their homes, she said. "There's a large probability that [Musk] will further develop Brownsville, but neglect the locals who were already here."

Leal said although the company's project will be amazing for the local economy, "Elon and SpaceX need to make sure that locals have a role in that development and don't push us aside. If he doesn't, then we risk losing our culture, land, customs, and traditions."

Low-income residents could be forced to leave their homes due to spiking prices caused by SpaceX's presence in the area, locals told Insider.

Musk announced the construction of SpaceX's facilities in 2014. Since then, the cost of living in the area has gradually increased as more people from across the US flock to Brownsville to work for the billionaire.

If the city of Starbase goes ahead, the small village and its leaders would have access to eminent domain, which could let them legally force holdouts to sell their homes, Insider reported May 8.

"The biggest concern is displacement," said Serrano. "Our home could be lost with rapidly increasing taxes or others who rent will be priced out."

Investors have been rushing to Brownsville to buy homes, sending house prices rocketing, Insider reported in April. But many residents aren't able to afford these prices, leaving them with a tough decision of whether to stay in the area or not.

Serrano said this could have a huge impact on the Buena Vida area of downtown Brownsville, a historically immigrant and Spanish speaking area.

Many of the locals who spoke to Insider believe the local leaders have a lot to answer for. Freddy Jimenez, editor of media platform Trucha, told us the leaders of Cameron County and City of Brownsville don't represent the everyday people living in the area as they look to profit from the space company's developments. Conversations between the representatives and SpaceX have been kept under the wraps, he added.

"Working people, community members, indigenous people, and the beautiful ecology of the region is being put at risk and exploited," Jimenez said. "Shame on our local leaders and shame on the interests they serve."

Robert Avitia, who was born and raised in Brownsville, still lives in the city where he runs his business. He thinks that SpaceX has done wonders by pumping more money into the area.

Although Avitia believes there are more positives than negatives with Musk coming to Brownsville, he agrees that rocket debris in the wildlife sanctuaries and the closing off of Boca Chica beach are serious issues in the community.

Boca Chica beach was a place where people could hang out whenever they wanted, Avitia told Insider.

"Now it's controlled. You can't get in and out whenever you want to. It's only when they allow it, based on what's happening at SpaceX," he said.

The beach was a big part of the culture in the area. Avitia recalled the fond memories he had with his father of coming down to the beach to fish. Now, SpaceX sometimes doesn't allow people to fish as it's too close to the facilities.

Hinojosa, who raised concerns about rocket litter earlier in this report, also said SpaceX closing off the beach access for locals threatens people's livelihoods by preventing people from fishing and feeding their families, and enjoying the beach.

But Avitia is one of the many people who welcome SpaceX's expansion in Brownsville. Beforehand, the city was a "ghost town" with little to offer, he said. Now, it's become more modern as new restaurants and businesses pop up on the streets, the tourism sector grows, and highways are updated he added.

"There is division here," he said. "You have people that are just comfortable and don't want to change... I hate to say this but the ones that want to stay comfortable are going to lose, they're going to miss out."

Restricting access to the beach and fishing comes with change, said Avitia.

"[Musk] donating money was like him saying, "Hey, I'm here to help. I'm not here to take away. I'm here to help." And I truly believe he's here to help," he added.

Four other people who spoke to Insider said they were also excited about Brownsville being the home of SpaceX.

One of them, Rudy Guzman, a lifelong resident of Brownsville, told Insider that SpaceX is exactly what the city needs "to attract outside investors and grow our local economy." Others said it would motivate children and make a huge improvement to education.

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SpaceX is causing division in Brownsville over disruption, economic impact - Business Insider