Scailyte Announces Michael Brenner, of Harvard Medical School, as an Advisor to Its Board of Directo – PharmiWeb.com

BASEL, Switzerland-June 22, 2021- (Newswire.com)

Artificial Intelligence (AI)-driven biomarker discovery innovator Scailyte announced today that Michael Brenner MD, Elizabeth Fay Brigham Professor of Medicine at Harvard Medical School, has joined Scailyte as an advisor to the Board of Directors.

Prof. Brenner is the director of Brigham and Women's Hospital's Human Immunology Center, which creates and performs single-cell transcriptional analysis and functional investigations in order to decipher human autoimmune illnesses, stratify patient groups, and find prospective therapeutic target cells and pathways. He is a member of the National Academy of Sciences in the United States and has received numerous awards.

Prof Brenner's research focuses on T cell biology, antigen presentation, microbial pathogenesis, and autoimmunity. His research discovered the integrin molecule aEb7 (CD103) and its role in leukocyte homing, as well as a role for the CD1 antigen presentation system in the activation of T cells and NKT cells. His team has recently identified distinct fibroblast subpopulations that are pathologically expanded in disease, as well as a new T helper cell population, T peripheral helper (Tph) cells, that are implicated in antibody production in autoantibody-mediated disorders.

Michael Brenner, MD comments: "I am thrilled to support Scailyte in their pioneering efforts combining single-cell technologies and artificial intelligence for biomarker discovery. Single-cell technology is moving into the clinical space, and Scailyte is there at the right moment to capture the potential and create a new generation of clinical applications that will make a difference for patients."

About Scailyte

Scailyte AG is a spin-off of ETH Zurich and combines single-cell technologies, high-quality datasets and machine learning methods to identify disease-specific biomarkers, with a focus on oncology and immunology. Scailyte's proprietary best-in-class data analysis platform ScaiVision associates multimodal single-cell datasets (RNA-/TCR-/BCR-seq, proteomics, etc) with clinical endpoints, such as disease diagnosis, progression, severity, treatment response, in order to identify ultra-sensitive biomarker signatures. Thanks to the single-cell resolution and AI-driven approach, ScaiVision is the most powerful and cutting-edge approach to develop methods for precise diagnosis and prediction of therapy response. Scailyte leverages a global network of clinicians to identify disease indications with high unmet needs and collaborates with global pharmaceutical and biotech companies to translate the novel biomarkers into ultra-sensitive companion diagnostics (CDx) and IVD assays.

For more information, visit http://www.scailyte.com and connect on social media @LinkedIn and @Twitter.

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Scailyte Announces Michael Brenner, of Harvard Medical School, as an Advisor to Its Board of Directo - PharmiWeb.com

Students studying medicine grapple with career path in light of pandemic: Did I make the right decision? – The Philadelphia Inquirer

In April, Sreya Pattipati, a pre-med student at the University of Pennsylvania, received a text from her aunt, a critical care specialist in India, where a dangerous second coronavirus wave was taking hold.

The waters are dark and deep at the moment. We are trying to hold on, the text read. My team and I are exhausted, depressed, and totally lost. I hope this ends soon.

Pattipati recently completed her first year virtually and has hopes to follow her aunt in a career in medicine. But the pandemics toll on health care workers physical and mental health, its exposure of serious gaps in the health care system, and her extended familys battle on the front lines in India has made her wary.

[The pandemic] made me deeply consider the profession that I wanted to go into, but I ultimately think it has motivated me more, she said. Her goal is to help decrease health disparities and increase access to high-quality care, and the pandemic highlighted those existing inequalities and how it was exacerbated, she said.

As it has for many of her peers, the pandemic has only confirmed her desire to become a doctor. Students studying medicine said they grappled with their career decision during the pandemic and had to reevaluate their reason for either sticking with it or switching paths.

Cody Ritz, a student at the Drexel University College of Medicine who recently completed his first year, couldnt help but second-guess his decision to become a doctor at the height of the pandemic.

It just felt like every other day, I was hearing some horror story or some burnout thing or some physicians taking their lives, because they couldnt handle the pressure, and seeing those things prompted me to search myself again and go back to my baseline motivations as to why I wanted to do medicine in the first place, he said.

The suicides of an emergency medical technician and emergency physician in New York City last year drew attention to the mental health crisis among health care workers. A Washington Post-Kaiser Family Foundation poll conducted in February found that about 30% of health care workers considered leaving their profession, while more than half felt burned out going to work.

The poll also found that younger health care workers were more likely to suffer from a mental health issue, with 75% of respondents under age 30 reporting worry or stress due to COVID-19.

Ritz said being at the beginning of the journey to becoming a doctor made the chaos that much more intimidating.

Did I make the right decision? he would ask himself. Am I doing the right thing? Is this really what I want to commit to?

The pandemic also highlighted the reality of practicing medicine, Ritz said.

As a med student, sometimes you can be optimistic in how you look at medicine, he said. You have all these goals of how you might be able to make a difference ... and then you see people who are in the thick of it.

Stephanie Javier Fagbemi, who recently began her fourth and final year at the Lewis Katz School of Medicine at Temple University, said, A lot of people have given their lives practicing medicine, especially during the pandemic because they were such selfless people. I dont want to lose my life, but I want to be as selfless as that care for my patients as if they were my family.

Anthony Scarpone-Lambert, who graduated from Penns School of Nursing in May, spent his final semester of clinical rotations in the emergency department of the Hospital of the University of Pennsylvania during the pandemic. There, he saw up close the exhaustion and lack of support that nurses were experiencing.

A lot of the nurses I was working with in the emergency department were changing to go to other units or specialties because there were a lot of challenges in the emergency room that were really frustrating to nurses, he said.

That inspired Scarpone-Lambert to explore a side of health care he had never considered before: entrepreneurship.

I was just always noticing so many insufficiencies that I felt inspired to find solutions for and make more of an impact by creating solutions that make sense for the front-line health care workers, he said.

Instead of becoming a clinical nurse, Scarpone-Lambert will work full time on his company Lumify Care, which provides wearable LED night-lights that do not disturb sleeping patients for health care workers.

I really enjoyed clinical care, but I think for me, specifically, especially during the pandemic, I realized that I really needed to almost be more of a leader in making more of an impact through entrepreneurship, he said.

Despite the many stressors of the pandemic, students said the last year has reinforced their desire to pursue a career in health care.

Students pointed to how the pandemic has highlighted the need to invest in public health, expand insurance coverage, and increase health care access for underserved populations.

Seeing those health disparities in an even more amplified light in the past year with COVID reinforced that the field in which I saw myself doing the most good was in medicine, said Heta Patel, an incoming first-year student at the Perelman School of Medicine.

Applications to medical schools in Philadelphia, and nationwide, soared this last admissions cycle. Temples masters of public health program saw a 120% increase in first-year students enrolled in 2020.

Ritz plans to take a year off from medical school to pursue a masters of public health at Drexel. The pandemics exposure of the health care systems flaws encouraged him to explore ways to avoid catastrophes such as the COVID-19 pandemic in the future, he said.

Pattipati, who is majoring in health and societies with a concentration in public health, said that although her aunts experiences in India prompted her to consider the drawbacks of certain specialties particularly those at the front lines the pandemic has only strengthened her interest in the policy side of health care.

I think what really struck me with this pandemic is that a lot of it was preventable, and I think thats what I hope to work toward: no unnecessary casualties, she said.

The Future of Work is produced with support from the William Penn Foundation and the Lenfest Institute for Journalism. Editorial content is created independently of the projects donors.

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Students studying medicine grapple with career path in light of pandemic: Did I make the right decision? - The Philadelphia Inquirer

LSU Shreveport med school whistleblower says she was illegally suspended from job in new suit – The Advocate

Dr. Ghali E. Ghali was reinstated by LSU late Wednesday as chancellor of the universitys medical school in Shreveport.

Ghali had been suspended on April 12, the day before four women at the LSU Health Sciences Center Shreveport officially filed federal Equal Employment Opportunity Commission complaints against Ghali claiming he had retaliated against them for raising sexual misconduct allegations against top administrators at the medical school.

Ghali released a statement Wednesday night after LSU's decision saying an outside investigation into the allegations has been concluded. "I have been advised that given the results of the investigation my administrative leave has ended and I have been returned to the active chancellor position without restrictions," Ghali wrote on official stationary identifying him as chancellor.

LSU confirmed his statement.

Allison Jones, the attorney for the four women who filed the federal complaints, said Wednesday night: Something is truly rotten in the State of Louisiana and at LSU. No investigation that was appropriately conducted could reach a conclusion that completely cleared Dr. Ghali of improper conduct. We should all demand immediate release of any investigatory report.

The action took place hours after one of the women filed a lawsuit in state district court claiming that she was illegally suspended from her job for blowing the whistle on the sexual harassment claims.

Dr. Jennifer Woerner, from whom some students had sought advice on what to do about sexual misconduct incidents, was one of four women who filed complaints against Ghali for allegedly retaliating against whistleblowers trying to bring attention to the claims. Three medical students came to me in writing about a host of offenses to include: writing pornographic book reports, asking students out for wine, derogatory comments about their looks, and taking photos of young women, Woerner wrote in her allegations formally filed April 13 with the federal EEOC. She also filed a complaint with the Louisiana Commission on Human Rights.

Jennifer Woerner M.D. v LSU Board of Supervisors, at al.

LSU System President Tom Galligan on April 12 suspended Ghali as chancellor, but allowed him to continue working and seeing patients at LSU Health Sciences Center Shreveport.

On May 21, Woerner was put on administrative leave pending an investigation into complaints against her, according to the lawsuit. She wasnt told the substance of the allegations against her or who had filed them. But Woerner was barred from campus. Staffers and students were told that they needed to contact the administration if Woerner attempted to contact them.

Ghali and another physician took over Woerners duties.

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We believe this is a direct retaliation against Dr. Woerner for her part in speaking out against injustices at the school, said Jones, Woerners attorney. We are very disappointed that the school has clearly acted in an unlawful and punitive manner.

LSU Health Shreveport offers no comment at this time, Lisa Babin, executive director of Communication and Public Affairs for LSU Health-Shreveport, said in a statement released Wednesday.

Dr. Ghali E. Ghali, chancellor of the LSU medical school in Shreveport, was put on administrative leave Tuesday, a day after four employees fi

The allegations against Ghali, a nationally recognized oral and maxillofacial surgeon, came as LSU came under fire over reports that university administrators had, for years, ignored and covered up the complaints of female students for subjected to sexual misconduct on the Baton Rouge campus. Galligan and the current LSU Board, saying the cover ups took place in the past, enacted sweeping and expensive changes to the way LSU handles sexual harassment complaints. The Louisiana Legislature passed requirements of strict oversight and reporting in the future.

Former LSU football coach Les Miles lost his job at the University of Kansas because of reports, which he denies, of improper conduct with female students. And former LSU President F. King Alexander, who was in charge at the time, resigned under pressure at his new post as head of Oregon State University for his role in the scandal. An associate athletic director filed a $50 million racketeering suit against the school.

Woerner, two physicians and a staffer alleged in the April EEOC filings that 16 medical students had reported being sexually harassed by an administrative faculty member and that the dean of admissions had required good-looking female applicants and students to write book reports on pornographic stories. Both of those accused administrators retired recently, but the LSU Health Sciences Center employees who students went to for help were denied promotions and saw their job duties constricted by Ghali, the women said.

Woerner pointed in her lawsuit to LSU bylaws that give only the Board of Supervisors or the LSU System president the authority to change the work conditions of tenured faculty, as she is.

It is one of the personnel action matters that cannot be further delegated. This, the Presidents authority to appoint and terminate tenured faculty can be exercised by the chancellors, but not by anyone subordinate to a chancellor, the lawsuit stated, adding that Woerner was suspended by an assistant chancellor. Dr. Ghali directly benefited from Dr. Woerner being removed from her duties as tenured faculty and placed on administrative leave. Once she was involuntarily relieved of her duties, he took over many of her duties and assigned other to his supporters.

Five more women have come forward to speak out about unresolved sexual harassment complaints at the LSU medical school in Shreveport, offering

First Judicial District Court Judge Craig Marcotte, of Shreveport, was assigned the case.

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LSU Shreveport med school whistleblower says she was illegally suspended from job in new suit - The Advocate

Shriver Center awarded five-year renewal of LEND program – UMass Medical School

The Eunice Kennedy Shriver Center announced the renewal of its Leadership Education in Neurodevelopmental Disabilities (LEND) Program for $3.1 million over the next five years.

Funded by the Health Resources Services Administrations Maternal & Child Health Bureau (HRSA/MCHB), the purpose of LEND program is to provide graduate-level interdisciplinary training to improve the health and well-being of children and youth with neurodevelopmental disabilities and their families. The LEND program prepares trainees from diverse professional disciplines and backgrounds to assume leadership roles in their respective fields, to serve as agents of systems change, to conduct research in the field, and to provide responsive and exceptional interdisciplinary clinical services.

The LEND program comprises two distinct training programs. The Advanced Leadership Fellowship Program, a nine-month intensive program that trains interdisciplinary cohorts of fellows in the knowledge, skills, and tools needed to effect systems change, make policy recommendations, develop and support evidence-based services, and devise new training methods. The Leadership in Interdisciplinary Clinical Care Program trains clinicians at the masters or doctoral level in an array of clinical disciplines to provide evidence-based, family-centered, culturally competent care for children and their families, and to assume leadership roles in their work. The training is carried out in affiliated programs within UMass Medical School and the Graduate School of Nursing as well as in clinical training sites at Tufts Medical Center and Franciscan Childrens.

Carol Curtin, PhD, professor of family medicine & community health, and LEND program director and principal investigator, said, We are delighted to be refunded for another five years and are proud of our LEND graduates who are at the table locally, regionally and nationally and part of critical conversations and efforts to improve services and supports for children with neurodevelopmental disabilities and their families. We look forward to continuing to train exemplary leaders and clinicians in the years that lie ahead.

For more information about the Shriver Center LEND program, visit: https://shriver.umassmed.edu/programs/lend/

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Shriver Center awarded five-year renewal of LEND program - UMass Medical School

In Memoriam: Jean Wilson, M.D., made scientific discoveries that led to effective prostate treatments, insights into sexual differentiation – UT…

DALLAS June 21, 2021 Jean D. Wilson, M.D., an internationally known endocrinologist whose scientific discoveries led to profound insights into the mechanisms underlying sexual differentiation and led to now widely used treatments for prostate disease, died June 13. He was 88.

Wilson, seen here in 1962, graduated from UTSouthwestern Medical School in 1955 and joined the faculty in 1960, where he began his studies of testosterone.

Wilson, professor emeritus of internal medicine at UTSouthwestern, was largely responsible for current understanding of the mechanisms by which steroid hormones induce male sexual differentiation. He also was instrumental in identifying the scientific underpinnings of a widely prescribed class of drugs known as 5-alpha-reductase inhibitors which include finasteride (Proscar, Propecia) and dutasteride (Avodart) to treat enlarged prostate and balding in men.

Wilsons discovery of 5-alpha-reductase and the identification of dihydrotestosterone as the primary hormone associated with the growth of the prostate transformed our understanding of prostate gland growth and paved the way for new effective treatment of prostate disease, says Daniel K. Podolsky, M.D., president of UTSouthwestern. His findings led to the first medical therapy for benign prostatic hyperplasia, and also provided the basis for understanding of the mechanism underlying the differentiation of male and female genital development. His legacy will be found in the legions of patients who have benefited from the therapy made possible by his discoveries.

Wilson, seen in 1978, was a popular and highly sought-after attending physician on the wards of Parkland Memorial Hospital, valued for his vast expertise in endocrinology and medicine in general.

Jean Wilson was one of the most critical and helpful sources of information concerning the development of two important drugs we were developing at Merck the statins, for control of LDL cholesterol, and Proscar, for treatment of benign prostate enlargement. Wilson was always available to wrestle with problems that often arise in drug development. I needed expert friends in those early days, and probably still do, says P. Roy Vagelos, M.D., former chairman, president, and chief executive officer of Merck & Co. and now chair of the board of Regeneron Pharmaceuticals.

Wilsons research included the study of cholesterol metabolism and steroid hormone action. The UTSouthwestern Medical School graduate and former National Institutes of Health (NIH) researcher earned international prominence for his investigations of testosterone including its formation from cholesterol as well as its metabolism and action. His efforts elucidated disorders resulting from genetic defects that lead to disruption in sex hormone biosynthesis with corresponding alteration in development.

Collaborations at UTSouthwestern with David Russell, Ph.D., professor of molecular genetics, led to the cloning of the 5-alpha-reductase (5AR) gene, development of animal models for 5AR deficiency, and eventually the finding that a 5AR inhibitor blocked prostate growth, which resulted in clinical trials led by Claus Roehrborn, M.D., chair of urology. The human androgen receptor later was cloned in 1989, allowing Wilson and colleagues to identify the receptor as a transcription factor that could regulate both the receptor and 5AR expression in prostate cancer. Other scientists at UTSouthwestern expanded upon his research, identifying androgen involvement in virtually all aspects of prostate development, alternate mechanisms of androgen synthesis, and other forms of androgens related to castrate-resistant prostate cancer.

Among his numerous awards, Wilson received the Kober Medal from the Association of American Physicians (1999); the Fred Conrad Koch Award from The Endocrine Society (1993); Gregory Pincus Award from the Worcester Foundation for Experimental Biology (1992); Henry Dale Medal from the Society for Endocrinology (1991); Amory Prize from the American Academy of Arts and Sciences (1977); and the Eugene Fuller Award from the American Urological Association. He was elected as a member of the American Academy of Arts and Sciences (1982), the National Academy of Sciences (1983), and the National Academy of Medicine (1994) as well as the American Philosophical Society and served as president of the Endocrine Society, the American Society for Clinical Investigation, and the Association of American Physicians.

Wilson, seen in 1992, was elected as a member of the American Academy of Arts and Sciences (1982), the National Academy of Sciences (1983), and the National Academy of Medicine (1994).

Wilson, who had held the Charles Cameron Sprague Distinguished Chair of Biomedical Research, was known as a collaborative colleague and empathetic adviser to students and fellows. His approach with students and trainees was threefold find out what they want to do, encourage them to do it, and develop pathways to fulfill their goals, he said in an interview with The Journal of Clinical Investigation. He also noted that some of the most difficult students to counsel turned out to be late bloomers who really were worth an investment of time and effort.

At UTSouthwestern, he served as the first director of the Medical Scientist Training Program, and it was recently announced that the Physician Scientist Training Program in Internal Medicine would be known as the Jean Wilson Society. The Jean D. Wilson Center for Biomedical Research and The Jean D. Wilson, M.D. Award, which honor excellence in scientific research mentorship, are named in his honor. The center was established with support from Dr. Wilson and his sister, the late Dr. Margaret Sitton, to promote research in endocrinology, developmental biology, and genetics, along with the J.D. and Maggie E. Wilson Distinguished Chair in Biomedical Research. In addition, he served among editors of two landmark medical textbooks Williams Textbook of Endocrinology and Harrisons Principles of Internal Medicine and as editor for The Journal of Clinical Investigation, among other journals. He authored The Memoir of a Fortunate Man, which chronicles his life growing up in the Texas Panhandle through his rise to pioneering academic physician and researcher.

Jean was a popular and highly sought-after attending physician on the wards of Parkland Memorial Hospital, valued for his vast expertise in endocrinology and medicine in general, say Nobel Laureates Joseph Goldstein, M.D, chair of molecular genetics, and Michael Brown, M.D., director of the Erik Jonsson Center for Research in Molecular Genetics and Human Disease. He founded a diabetic foot clinic at Parkland and spent hours each week clipping toenails and treating ulcers on the feet of elderly diabetic patients. After long days on the wards, he would retire to his modest laboratory where he would spend half the night meticulously dissecting rabbit fetuses. Often, when we were just starting our careers, we would sit by his side while he dissected, receiving sage advice about our careers as physician-scientists and life in general. Later, he extended his fatherly role to generations of M.D./Ph.D. students when he became the founding director of our M.D./Ph.D. program.

He had a rich life outside of the Medical Center as well. An avid opera buff, Wilson collected antique gramophones that could play every type of recording that had ever been produced. His extensive collection of 3,500 old 78-rpm operatic recordings included a 1917 disc of Enrico Caruso singing songs of Irving Berlin the only record that Caruso ever recorded in English, they note.

An avid opera buff, Wilson, seen in 2019, collected antique gramophones. His extensive collection of 3,500 old 78-rpm operatic recordings included a 1917 disc of Enrico Caruso singing songs of Irving Berlin the only record that Caruso ever recorded in English.

He took memorable trips to places like the North Pole, Antarctica, the Galapagos Islands, and the Easter Islands. He often incorporated science into his trips, visiting the Kangaroo Island in Australia to study sexual development in wallabies, and to Kenya to biopsy the phallus of the spotted hyena. Fearless in the pursuit of knowledge, he performed a rectal examination on a lion to estimate the size of the prostate, Goldstein and Brown say. A dedicated bird watcher, he traveled the world to many exotic places, hoping to spot that rare bird. But in the end, the rarest of that rare bird was Jean Wilson himself.

Born in Wellington, Texas, in 1932, Wilson obtained an undergraduate degree in chemistry from UT Austin and graduated from UTSouthwestern Medical School in 1955. As a student, he studied the control of urinary acid secretion by adrenal hormones, and as a resident, he investigated cholesterol metabolism. After residency, he spent two years at the NIH, where he studied ethanolamine biosynthesis. He joined the UTSouthwestern faculty in 1960 where he began his studies of testosterone, and worked in 1970 at Cambridge University. In all, he spent 60 years at UTSouthwestern and was named professor emeritus of UTSouthwesterns storied internal medicine department in 2011.

Jean Wilson leaves us with a remarkable legacy a quintessential physician-scientist whose scholarship both inspires and continues to serve as a foundation for new advances, says Podolsky, also professor of internal medicine.

In a career spanning six decades at UTSouthwestern, Dr. Jean Wilsons discoveries included:

Cholesterol metabolism

Dr. Wilson developed methods for quantifying cholesterol synthesis, absorption, degradation, and excretion in lab animals. Together, these analytical methods served as tools for understanding the feedback control of cholesterol synthesis and turnover. In addition, Dr. Wilson demonstrated that plasma cholesterol is synthesized in the intestinal wall and liver, findings that helped researchers define the contributions of diet and endogenous synthesis to cholesterol turnover in humans and other primates.

Male androgens

Concurrently, Dr. Wilson studied the action of male androgens, focusing on testosterone and its metabolite, dihydrotestosterone. Starting with a collaboration with his postdoctoral fellow, Nicholas Bruchovsky, in 1966, the researchers discovered that testosterone is converted inside prostate cells into dihydrotestosterone, a more potent androgen that is responsible for most of male sexual maturation and male sexual function. Dr. Wilson and his colleagues later showed that mutations that impair either the synthesis of testosterone, the conversion of testosterone to dihydrotestosterone, or the function of this metabolites receptor protein are the most common cause of birth defects associated with incomplete development of the male urogenital tract, affecting about four in every 1,000 boys. Cloning these responsible genes eventually allowed researchers to identify asymptomatic carriers of these mutations.

Dihydrotestosterone

Dr. Wilson also discovered that excess dihydrotestosterone is responsible for benign prostatic hyperplasia (BPH), or prostate enlargement, a condition that affects about 210 million men worldwide. Dihydrotestosterone is responsible for prostate growth in all male mammals, but in humans and dogs, prostate growth continues throughout life. Wilson and his colleagues showed that local excess of this potent androgen leads to prostate overgrowth. By curbing its production by inhibiting 5a-reductase, the enzyme that converts testosterone to dihydrotestosterone, they were able to prevent BPH in dog models of this condition. These findings have been developed into multiple 5a-reductase-inhibiting pharmaceuticals to treat this condition in human patients.

Brown, a Regental professor and director of the Erik Jonsson Center for Research in Molecular Genetics and Human Disease, holds The W.A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research, and the Paul J. Thomas Chair in Medicine.

Goldstein, a Regental professor and chair of molecular genetics, holds the Julie and Louis A. Beecherl, Jr. Distinguished Chair in Biomedical Research, and the Paul J. Thomas Chair in Medicine.

Podolsky holds the Philip OBryan Montgomery, Jr., M.D. Distinguished Presidential Chair in Academic Administration, and the Doris and Bryan Wildenthal Distinguished Chair in Medical Science.

Russell holds the Eugene McDermott Distinguished Chair in Molecular Genetics.

About UTSouthwestern Medical Center

UTSouthwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institutions faculty has received six Nobel Prizes, and includes 24 members of the National Academy of Sciences, 16 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UTSouthwestern physicians provide care in about 80 specialties to more than 117,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 3 million outpatient visits a year.

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In Memoriam: Jean Wilson, M.D., made scientific discoveries that led to effective prostate treatments, insights into sexual differentiation - UT...

Investigational Alzheimer’s drug improves biomarkers of the disease Washington University School of Medicine in St. Louis – Washington University…

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International clinical trial yields mixed results with unclear cognitive effects but promising biomarker results

Randall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate experimental Alzheimers drugs, speaks with DIAN-TU participant Taylor Hutton. One of the drugs tested in the DIAN-TU, gantenerumab, improved biomarkers of disease despite unclear cognitive effects, prompting study leaders to offer participants the option of continuing to receive the drug and participate in follow-up examinations as part of a so-called open label extension.

An investigational Alzheimers drug reduced molecular markers of disease and curbed neurodegeneration in the brain, without demonstrating evidence of cognitive benefit, in a phase 2/3 clinical trial led by researchers at Washington University School of Medicine in St. Louis through its Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU). These results led the trial leaders to offer the drug, known as gantenerumab, to participants as part of an exploratory open-label extension. The researchers continue to monitor changes in measures of Alzheimers disease in those participants who are receiving the drug.

The DIAN-TU study (ClinicalTrials.gov Identifier: NCT01760005), published June 21 in Nature Medicine, evaluated the effects of two investigational drugs gantenerumab, made by Roche and its U.S. affiliate, Genentech, and solanezumab, made by Eli Lilly and Co. in people with a rare, inherited, early-onset form of Alzheimers known as dominantly inherited Alzheimers disease or autosomal dominant Alzheimers disease. Such people are born with a mutation that causes Alzheimers, and experience declines in memory and thinking skills starting as early as their 30s or 40s.

Gantenerumab had a major impact on Alzheimers biomarkers, said principal investigator Randall J. Bateman, MD, director of DIAN-TU and the Charles F. and Joanne Knight Distinguished Professor of Neurology at Washington University. The drugs ability to shift multiple Alzheimers biomarkers toward normal indicates that it is positively affecting the disease process. The effect was strong enough that we launched an open-label extension of the trial so participants have the opportunity to stay on the drug as we continue to study it.

Over the past few decades, scientists have pieced together the changes that occur as Alzheimers develops, a process that takes 20 years or more. First, the protein amyloid beta starts forming plaques in the brain. Later, levels of tau and neurofilament light chain rise in the cerebrospinal fluid that surrounds the brain and spinal cord, and the brain begins to shrink. Then, tangles of tau protein form in the brain. Only then do people with the disease start exhibiting signs of memory loss and confusion.

In this study, 52 patients were randomized to gantenerumab, which led to a reduction in the amount of amyloid plaques in the brain, and lowered soluble tau and phospho-tau, and slowed the rise of neurofilament light chain levels in the cerebrospinal fluid. Neurofilament light chain is a marker that reflects neurodegeneration. Overall, gantenerumabs safety profile in this trial was consistent with that from other clinical trials of the investigational medicine, and no new safety issues were identified.

The primary endpoint of the DIAN-TU study was the prevention or slowing of cognitive decline in people who are nearly certain to develop Alzheimers due to genetic mutations. Neither drug met the primary endpoint, although the study wasnt able to determine effects on thinking and memory in participants who entered the study without symptoms, because they exhibited little to no decline in cognitive function. The study also was unable to assess the effects of higher doses of the drugs, which were escalated to the desired levels late in the trial after a protocol amendment. Participants who received gantenerumab started on a low dose and only started ramping up to a fivefold higher target dose about halfway through the trial, prompted by observations from other studies of gantenerumab.

However, as a secondary endpoint, the study also evaluated the effect of the drugs on molecular and cellular signs of Alzheimers disease. On these measures, gantenerumab showed potential benefit.

These biomarker results suggest that gantenerumab had a favorable impact on the target and downstream markers of Dominantly Inherited Alzheimers Disease, said Rachelle Doody, MD, PhD, global head of neurodegeneration at Roche and Genentech. We support the continued scientific investigation of gantenerumab in Washington Universitys exploratory, open-label extension study to build on learnings from DIAN-TU-001, and are grateful to be a part of this close collaboration between industry, academia and patients as we continue to tackle the complex challenge of Alzheimers disease. We are encouraged by the advancements being made and look forward to continued progress for people with Alzheimers disease.

This trial followed 144 participants for up to seven years; the average follow-up was about five years. All participants carry a genetic mutation that causes a form of Alzheimers dementia at early ages. The researchers recruited participants who were expected to develop symptoms within 15 years or who already had very mild symptoms of memory loss and cognitive decline at the trials outset. In most cases, their brains already showed early signs of disease. Participants were randomly assigned to receive solanezumab, gantenerumab or a placebo.

Although the trial focuses on people with rare mutations, drugs that are successful in this population would be promising candidates for preventing or treating the forms of Alzheimers that occur more commonly in older adults. The destructive molecular and cellular processes in the brain are similar in both types of the disease, Bateman said.

Salloway S, Farlow M, et al. A Trial of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimers Disease. Nature Medicine. June 21, 2021. DOI: 10.1038/s41591-021-01369-8

Data analyzed in this paper was obtained with the support of the National Institute on Aging of the National Institutes of Health (NIH), grant numbers U01AG042791, U01AG042791-S1, R01AG046179, R01AG053267-S1 and U19AG032438; the Alzheimers Association; Eli Lilly and Co.; Roche and Genentech, a member of the Roche group; Avid Radiopharmaceuticals; GHR Foundation; an anonymous organization; Cogstate; Signant; the German Center for Neurodegenerative Diseases; the Raul Carrea Institute for Neurological Research; the Japan Agency for Medical Research and Development; and the Korea Health Industry Development Institute.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, consistently ranking among the top medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Investigational Alzheimer's drug improves biomarkers of the disease Washington University School of Medicine in St. Louis - Washington University...

NASA’s Ingenuity Mission Honored by the Space Foundation NASA’s Mars Exploration Program – NASA Mars Exploration

Ingenuity Flight Six Navcam Image: This sequence of images taken on May 22, 2021, by the navigation camera aboard NASAs Ingenuity Mars Helicopter shows the last 29 seconds of the rotorcrafts sixth flight. Credits: NASA/JPL-Caltech. Download video

The mission picked up the 2021 John L. Jack Swigert, Jr., Award for Space Exploration for its history-making achievements.

The team behind NASAs Ingenuity Mars Helicopter has been named the 2021 winner of the John L. Jack Swigert, Jr. Award for Space Exploration from the Space Foundation.

The foundations goal is Advocating for Innovation. Bettering Life on Earth. The annual award recognizes extraordinary accomplishments by a company, space agency, or consortium of organizations in the realm of space exploration and discovery. It honors the memory of astronaut John L. Jack Swigert, Jr., the command module pilot for the Apollo 13 mission. During Apollo 13s April 1970 voyage to the Moon, an oxygen tank ruptured, placing the crew in peril. It was a time of high drama and high anxiety as people around the globe watched NASA work against the clock and against the odds to return the crew safely to Earth.

The Ingenuity Mars Helicopter team at NASAs Jet Propulsion Laboratory in Southern California faced many challenges on their way to achieving humankinds first powered, controlled flight on another planet. The helicopters first test flight was full of unknowns. The Red Planet has an extremely thin atmosphere with only 1% the pressure at the surface compared to our planet while also being home to significant gravity one-third that of Earth. On April 19, 2021, Ingenuity climbed to its prescribed maximum altitude of 10 feet (3 meters) and maintained a stable hover for 30 seconds before descending again, becoming the first ever rotorcraft to fly on another planet.

Since then, the Mars Helicopter has flown a total of seven times, transitioning from being a technology demonstration to an operations demonstration intended to explore how aerial scouting and other functions could benefit future explorations of Mars and other worlds.

The Space Foundation award will be presented Aug. 23 during the opening ceremony of the 36th Space Symposium in Colorado Springs.

Recent Swigert Award winners include the InSight-Mars Cube One joint project teams, the Dawn mission, and the Cassini mission.

News Media Contact

DC Agle Jet Propulsion Laboratory, Pasadena, Calif.818-393-9011agle@jpl.nasa.gov

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NASA's Ingenuity Mission Honored by the Space Foundation NASA's Mars Exploration Program - NASA Mars Exploration

Mars: Humans able to reproduce on planet, sperm can survive for 200 years – Business Insider

Human reproduction will be possible on Mars because sperm can survive there for up to 200 years, astudysuggests.

The findings were part of a six-year experiment in which scientists kept mouse sperm on the International Space Station and exposed it to radiation.

As The Daily Mail reports, researchers had believed radiation in space would destroy human DNA and make breeding impossible. Cancer caused by the radiation was another concern.

But after six years, scientists found that the mouse sperm stored on the space station was still healthy.

They also exposed it to X-rays on Earth and discovered it did not affect fertility.

One of the study's authors, Professor Sayaka Wakayama, of Japan's University of Yamanashi, told The Daily Mail: "Many genetically normal offspring were obtained. These discoveries are essential for mankind to progress into the space age."

"When the time comes to migrate to other planets, we will need to maintain the diversity of genetic resources, not only for humans but also for pets and domestic animals," he added.

Mars exploration has ramped up this year, as NASA's Perseverance rover and Ingenuity helicopter continue to look for signs of life on the planet.

Ingenuity, which is carried inside Perseverance's belly, recently completed its seventh flight on Mars. As reported by Insider's Kate Duffy, Perseverance is due to travel three miles across Mars over the next few months.

The rover's trip will help NASA understand the geology of Jezero Crater, the agency said in a statement.

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Mars: Humans able to reproduce on planet, sperm can survive for 200 years - Business Insider

Encore: The Princess and the Egg – WBUR

Whens the last time you made a promise?

Maybe you gave your word that youd help wash the dinner dishes. Or you borrowed a friends book, and told her youd return it by the end of the week.

When we make promises, were giving the message that well do what we say.

In this favorite tale from Circle Round Season 2, we meet a princess who makes an important promise. But when she tries to keep that promise, shes thrown for a real loop!

Story continues below

Subscribe to the podcast

Our tale is called The Princess and the Egg. Youll hear versions of this story in many places, from Portugal and Denmark in Europe, to the Mediterranean world and Middle East, to the island nation of Haiti!

Voices in this episode include Luis Negron, Jeff Song and Amber Stevens West. Grown-ups, watch for Amber on the CBS sitcom, Happy Together, as well as the Starz comedy, Run the World.

This episode was adapted for Circle Round by Rebecca Sheir. Original music and sound design is by Eric Shimelonis. Our artist is Sabina Hahn.

This episode was originally released on October 23, 2018.

Coloring Page

ADULTS! PRINT THISso everyone can color while listening. Were also keeping an album so share your picture on Facebook, Twitter, Instagram, and tag it with #CircleRound. We'd love to see it! To access all the coloring pages for past episodes click HERE. Our resident artist is Sabina Hahn and you can learn more about her HERE.

Things To Think About After Listening

Think of a promise youve made.

What was your promise?

And who did you make it to?

Now, find someone you like to have fun with a family member or friend and tell that person all about your promise and whether you did, indeed, follow through!

Musical Spotlight: Harpsichord

The stringed keyboard instrument known as the harpsichord is shaped like a grand piano, and most likely was developed in the late Middle Ages.

The harpsichord can have one keyboard or two; either way, when you hit a key, a small piece of material known as a plectrum plucks a metal string and voila! You have sound. The problem is, you dont have control over how loud or soft that sound is, so when the more dynamic piano came along, that more modern instrument pretty much superseded the harpsichord. Still, youll hear plenty of the harpsichords charming, elegant, even formal sound in renaissance and baroque music and in 1960s baroque pop songs by such bands as The Beatles and The Rolling Stones.

Script:

NARRATOR: All her life Princess Pearl dreamed of traveling the world. She wanted to see new places, try new foods, and meet new friends.

But what she didnt want was to have people bowing down to her at every port of call, just because she was royalty. So she swore that when she finally got to embark on her adventure, she would never wear her crown. No one would know she was a princess.

Once Princess Pearl finished all of her schooling, the King and Queen surprised their daughter with a swift, sturdy sailboat to whisk her around the high seas, and a brand new atlas, so she wouldnt lose her way.

PEARL: Oh, Mother! Father! Thank you for these gifts! I cant wait to start my journey. I promise Ill send you a letter from every port I visit!

NARRATOR: But Princess Pearl was not able to fulfill that promise.

On her very first night at sea, do you know what happened? A massive storm blew in, and gusts of wind and rain tossed her sailboat this way and that!

Pearl clung to the boats ropes as wave after wave frothed and foamed across the deck. The next thing she knew, it was morning and she and her ship were washed up on an empty beach.

PEARL: Well, this trip isnt off to a very good start. (as she looks at boat) Yikes - look at this boat! What a wreck. I should thank my lucky stars it got me to shore!

NARRATOR: Pearl pulled off her soggy shoes and jumped down from the splintered remains of her sailboat. As her bare feet touched the soft, warm sand, the princess looked around her. Her heart leapt when she spotted a quaint seaside town in the distance.

PEARL: Oh boy! Civilization!

NARRATOR: Pearl sprinted across the beach. When she got to town, she stepped inside the first establishment she saw: a tiny little bed and breakfast. Thats a small hotel, or inn, where people can spend the night and enjoy a nice morning meal.

The innkeeper narrowed his eyes as Pearl entered. He wrinkled his nose as he beheld her torn, drenched clothing and bare feet - not to mention the seashells and seaweed sticking out of her soaking-wet hair!

INNKEEPER: May I help you?

NARRATOR: Pearl flashed her warmest smile.

PEARL: Why, yes, you may - thank you! Do you serve breakfast? Im so hungry I could eat a life preserver!

NARRATOR: The innkeeper sniffed.

INNKEEPER: Well, it just so happens we do serve breakfast... given that were a bed and breakfast and all. But were about to close the kitchen.

NARRATOR: One thing you should know about the innkeeper: he was a very greedy man. So although the kitchen was closing, he suddenly realized he had one last chance to make a few extra bucks. He softened his tone.

INNKEEPER: Look. I tell you what. Ill have the cook whip up something for you - something fast and simple. How about... a scrambled egg?

NARRATOR: Pearls mouth watered.

PEARL: Oh - that would be lovely! My stomachs rumbling so loudly, youd think Ive got an orchestra in there! Not a very good one... the timpani is way too loud and the tuba is hopelessly out of tune... but -

INNKEEPER: Yeah, yeah, yeah. Have a seat. One scrambled egg, coming right up.

NARRATOR: As you can imagine, that one scrambled egg was the best scrambled egg Pearl had ever tasted! Within seconds, her plate was empty. She raised her hand and called the innkeeper over.

INNKEEPER: What now?

PEARL: Well, first, thank you for the egg, sir. It was delicious! But, you see, when I rushed over here for breakfast, I kind of forgot one teensy-weeny little thing. I dont have any money.

NARRATOR: The innkeepers eyebrows shot up so high, they disappeared into his hairline.

INNKEEPER: Come again?

PEARL: I said, I dont have any money. You see, yesterday, I set out on a sailing trip around the world. Then this massive storm blew in, and I was sure I was a goner. But the winds blew me to your lovely town... and when I came to your inn for breakfast, I didnt even think about the fact that my money everything I own, actually got lost at sea!

NARRATOR: The innkeeper took a deep breath.

INNKEEPER: Okay So how, then, do you propose paying for that one scrambled egg? It costs two gold coins, you know!

PEARL: I know. And I promise: I will return to this town, and when I do, you will get your money.

NARRATOR: The innkeeper glanced again at Pearls bare feet and soggy clothing and the seashells and seaweed sticking out of her hair.

INNKEEPER: And why should I believe youll actually come back and pay up?

NARRATOR: Pearl shrugged.

PEARL: Lets just say I have some savings back home. Thanks again for the egg, sir. Have a good day!

NARRATOR: As Pearl waltzed out of the bed and breakfast and onto the street, the innkeeper grumbled to himself.

INNKEEPER: I have some savings back home. Sure ya do! Ugh. What a waste of a perfectly good egg. I bet Ill never see that ragamuffin again!

NARRATOR: As it turns out, the innkeeper was right and very, very wrong.

NARRATOR: What do you think will happen? Will the princess come back to settle her debt?

Well find out, after a quick break.

[MIDROLL]

NARRATOR: Welcome back to Circle Round. Im Rebecca Sheir. Today our story is called The Princess and the Egg." When we left off, Princess Pearl had promised a greedy innkeeper that shed come back and pay for one scrambled egg. Her sailboat had crashed in the innkeepers quaint seaside town, so she wasnt able to give him the two gold coins necessary to cover the meal.

After her shipwreck, Princess Pearl eventually found her way back to her own kingdom. The king and queen hugged their daughter extra tight when she got home. Then they surprised her with an even bigger boat, with even more sails so that she could try again with her world travels.

And she did.

Several months into her journey, she found herself back at the quaint seaside town: the one where shed been shipwrecked and where she had a debt to settle with the owner of the bed and breakfast.

But this time when she stepped into the cafe, she was not barefoot; on her feet she wore a pair of fine leather boots. Her clothing was well-tailored and trim. And her hair wasnt disheveled and strewn with sea life; it was tucked neatly beneath a green velvet cap.

As you can imagine, the innkeeper did not recognize her.

INNKEEPER: May I help you?

PEARL: Yes, I think you may! Several months ago, I got into a shipwreck and was unable to pay you for one scrambled egg: a humble breakfast that cost two gold coins. I promised Id come back and pay for that delicious meal. And... here I am!

NARRATOR: The innkeeper stared at Pearl with disbelief. Was this really the same ragamuffin from all those months ago? She looked so fancy, so elegant!

PEARL: And further, sir, to thank you for your generosity and your patience I intend to pay you double. No - make it quadruple. So, instead of two gold coins, that would be, what, eight?

NARRATOR: The innkeeper thought for a moment. Why should this prosperous woman pay a mere eight gold coins when obviously she could pay so much more?

INNKEEPER: Im sorry. Eight gold coins, you say? No, no! You owe me far more than eight gold coins.

NARRATOR: Pearl was confused.

PEARL: I do?

INNKEEPER: You bet you do! Think about it. If I hadnt served you that one scrambled egg, that egg would have hatched into a chick! And then that chick would have grown up and laid eggs and hatched a dozen more chicks! And each one of those chicks would have gone on to lay eggs and hatch a dozen more chicks! You see where Im going with this?

NARRATOR: Pearl shook her head.

PEARL: Um, Im not sure I -

INNKEEPER: Long story short... you dont owe me eight gold coins. You owe me

NARRATOR: He pulled out a pencil, grabbed a napkin, and began scribbling.

INNKEEPER: (to himself, as he scribbles his calculations on the napkin) Lets see multiply this times this, add up that and that Okay uh-huh alright. You owe me eight-million gold coins.

PEARL: Im sorry eight-million?!?!

INNKEEPER: Yup! Eight-million! I mean, give or take a few thousand. I rounded down. Figured Id give you a bit of a discount.

NARRATOR: Pearl could hardly believe what she was hearing.

PEARL: But sir, I cant pay you eight-million gold coins!

NARRATOR: The innkeeper scowled.

INNKEEPER: Really? You cant pay?

NARRATOR: He gestured toward Pearls fancy clothes and shoes.

INNKEEPER: ...or you wont pay?

NARRATOR: Pearls mind raced. She reached into her purse.

PEARL: Look. What do you say I give you a hundred gold coins and we call it a deal.

NARRATOR: The innkeeper fixed Pearl with a steely gaze. He crossed his arms.

INNKEEPER: Nope. Eight-million gold coins, or I see you in court. Tomorrow.

NARRATOR: Pearl sighed.

PEARL: Alright, then. See you in court.

NARRATOR: As Pearl sat down to dinner that night in another hotel, blocks away from the bed and breakfast she was so distraught could hardly eat. She picked at her boiled peas took half-hearted nibbles of her steamed corn and by the time dessert was served a warm bowl of roasted chestnuts she couldnt even take a bite.

She stared at her plate of food, wondering what in the world she would do tomorrow in court.

Then, suddenly, it hit her.

PEARL: Ive got it! The answer is in the peas! And the corn! And the chestnuts! Id better get some sleep; tomorrow is going to be a big day.

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Encore: The Princess and the Egg - WBUR

‘Smart drugs’ are real here’s what’s scientifically proven and how to tell if nootropics are right for you – Insider

Whether you're a student cramming for finals, an employee on a project deadline, or your mind just isn't as clear as it once was, you might wish there was a magic pill you could take that would supercharge your brain and make everything a little easier.

Nootropics aren't magic pills, and they won't supercharge your brain, but they do have the potential to improve your cognitive functioning under the right circumstances.

Here's more about nootropics as well as specific types that have been proven to provide some level of cognitive enhancement.

Nootropics are colloquially called "smart drugs" or "cognitive enhancers" due to the fact that they might theoretically boost brain function especially regarding energy, focus, and memory.

Natural nootropics may also increase blood circulation and oxygen flow to the brain, according to a 2016 study. This is beneficial for brain health, since the brain depends on a continuous supply of oxygen and nutrients to function properly.

But nootropics likely won't provide you much benefit if you're not already experiencing symptoms such as trouble focusing or poor memory, says David A. Merrill, MD, a psychiatrist and director of the Pacific Neuroscience Institute's Pacific Brain Health Center at Providence Saint John's Health Center.

There are a number of factors that can affect your cognitive performance such as your sleep, stress levels, diet, and exercise regimen. You should try to improve these factors rather than simply relying on nootropics, as this will be much more beneficial in the long run, Merrill says.

There are various natural, over-the-counter, nootropics to choose from that are available in supplement form. You can usually find them at your local grocery or online. Here are five common nootropics as well as how they work.

Caffeine in the form of coffee, tea, energy drinks, supplements, and more is the most commonly used nootropic worldwide.

It works by blocking adenosine receptors in the brain that make you feel tired. That's why caffeine often makes people feel less tired and more alert and focused.

However, Merrill notes that there are two problems with caffeine. First, if you consume it often, you will become tolerant to it, meaning that you will require more and more caffeine to feel a boost. Secondly, if you overdo your caffeine consumption, it can lead to side effects like anxiety, insomnia, and tremors.

Ginkgo biloba is a plant, and you can find its extract in supplement form. Merrill says ginkgo biloba extract works by increasing blood flow to the brain, or cerebral blood flow. In theory, this can be beneficial because it prevents decreased cerebral blood flow, which can result in cognitive decline.

Much of the research surrounding ginkgo biloba is in regards to Alzheimer's. For example, a 2020 review of 28 studies found that taking 240 milligrams of ginkgo biloba daily had a positive impact on cognitive function including reaction time and memory in adults with mild Alzheimer's.

However, if you're not already suffering from cognitive decline, Merrill says you may not experience any kind of boost from ginkgo biloba.

L-theanine is found naturally in green tea and black tea, but it can also be taken as a supplement. Merrill says it tends to have a calming, relaxing effect while also boosting alertnesswhich is why it's categorized as a nootropic.

L-theanine works by boosting serotonin, dopamine, and GABA levels. GABA are neurotransmitters that play a part in mood and stress regulation.

A 2019 study found that participants who took 200 milligrams of L-theanine tablets for four weeks experienced reduced stress and improved executive functioning.

"Omega-3 fatty acids are the building blocks of brain cell membranes, increasing cell membrane fluidity, which is important for the functioning of each brain cell," says Merrill.

A 2012 analysis showed that adults with a mild form of cognitive impairment who took omega-3 supplements saw an improvement in cognitive function.

But while some research has been promising, other studies found that omega-3s had no effect on cognition for a sample of healthy adults aged 18-35. Therefore, omega-3 supplements may be most beneficial for people who are already experiencing some form of cognitive decline.

Creatine is an amino acid that may benefit cognitive function due to the way it interacts with brain cells.

"Brain cells require high amounts of energy to function, and creatine can help brain cells continue to produce the energy needed to think," says Merrill.

A 2018 systematic review found that taking creatine supplements can improve short-term memory in healthy individuals.

Those who have a condition that severely impairs their cognitive function may benefit from more potent, prescription nootropics. Here are two common prescription nootropics and how they work.

Adderall is a prescription drug commonly prescribed to people with ADHD but it may also be prescribed for narcolepsy. Merrill says Adderall is a stimulant that works by increasing your levels of dopamine and norepinephrine. These chemicals can improve your focus and concentration.

Additionally, Adderall has been shown to boost alertness, energy levels, and attention span in people with ADHD or narcolepsy.

"There appears to be a ceiling effect with stimulants like Adderall, so they can reduce attention deficits, but they won't make individuals with already normal levels of attention super-smart," says Merrill.

Modafinil is a prescription drug that promotes wakefulness, and it's prescribed to people who have narcolepsy, obstructive sleep apnea, or shift work sleep disorder.

The way modafinil works is mostly to increase dopamine levels. These increased dopamine levels may help concentration, memory, and motivation,, says Merrill.

A 2020 study found that modafinil improves cognitive function in healthy adults, such as improving working memory and accuracy when completing tasks. However, it is not usually prescribed to people who don't have a sleep disorder.

There are many nootropics to choose from if you're looking to boost your cognitive function. However, it's important to be realistic and remember that you will likely not experience drastic changes, if any changes at all if you're otherwise healthy. Always consult your doctor before taking any supplements such as these nootropics.

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'Smart drugs' are real here's what's scientifically proven and how to tell if nootropics are right for you - Insider

Do Brain Supplements Really Improve Focus & Memory? Here’s What the Science Says – Yahoo Lifestyle

Who doesn't want to be smarter, sharper and more focused and creative? Nootropics (pronounced new-traw-picks) promise all of this and more. These "smart pills"-which are a group of natural and synthetic compounds, often found in supplement or prescription form- might sound new, but nootropics have been around since the early 1970s, when Romanian psychologist and chemist Corneliu Giurgea created a synthetic substance called piracetam to improve learning and memory and coined the term.

Nootropics gets its name from the Greek words nous ("mind") and trepein ("bend or turn"). There are more than 130 over-the-counter nootropics-including ginseng, ginkgo, guarana, creatine, caffeine and Bacopa monnieri as well as piracetam-plus Rx versions, such as the ADHD medications Adderall and Ritalin, and Aricept, an Alzheimer's treatment.

Today, nootropics and other brain health supplements are a billion-dollar industry in the U.S. And of the estimated 16 million American adults who use stimulants like Adderall, about 5 million do so off-label, with half of those specifically aiming to enhance their brainpower. "People will jump at any opportunity to try something that might be mentally curative or restorative," says Maya Babu, M.D., M.B.A., a neurosurgeon at Cleveland Clinic Martin Health in Port Saint Lucie, Florida. "Younger people are interested in potential memory and attention benefits, while those who are older are concerned about dementia."

Getty Images / JESPER KLAUSEN / SCIENCE PHOTO LIBRARY / ViewStock

But do OTC nootropics work? The research says: not so much. When scientists reviewed 394 studies for a 2020 Nutrients review on nootropics, they ended up tossing out 73% due to low quality (meaning the results didn't hold up to rigorous scientific scrutiny). After scrutinizing those that remained, they concluded that the only supplement that might be useful was caffeine, showing promise for improving memory, attention, problem-solving and reasoning. And even that was mostly among sleep-deprived people.

There are also safety concerns. Supplements aren't subject to the same clinical trials as prescription drugs, and many of their labels are riddled with unsubstantiated claims. The issue is so problematic that in 2019, the FDA and the Federal Trade Commission sent letters to three nootropic supplement manufacturers demanding them to promptly correct the false or misleading claims on their labels. One ginkgo biloba brand got a slap on the wrist for touting its ability to improve memory. And a purveyor of colostrum supplements got called out for its Alzheimer's prevention claims.

As for prescription nootropics? "For patients with true ADHD or dementia, certain medications can be tremendously helpful for attention, alertness and focus," says Babu. "But for those without these underlying conditions, I haven't seen data that nootropics can increase performance in any way." Indeed, a 2016 American Academy of Family Physicians review found no evidence that Alzheimer's medications do anything to improve mental function in healthy people and that the impact of ADHD medications for those without the condition are modest at best. "In the end, I don't think nootropics can replace sleep, healthy diet, physical activity and memory exercises," says Babu. "I'd hate to see people think they will benefit them in any meaningful way." Next time you're looking for a brain boost? Her advice: Try a strong cup of coffee.

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Do Brain Supplements Really Improve Focus & Memory? Here's What the Science Says - Yahoo Lifestyle

Nootropics Brain Supplements Market 2021 2027 | Growth Dynamics, Revenue Outlook and Opportunities Forecast Excelerol, Zhou Nutrition, Neurofuse The…

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Global Nootropics Brain Supplements Market by Type: Pills, Liquid, Capsule, Other

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TOC

1 Nootropics Brain Supplements Market Overview1.1 Nootropics Brain Supplements Product Overview1.2 Nootropics Brain Supplements Market Segment by Type1.2.1 Pills1.2.2 Liquid1.2.3 Capsule1.2.4 Other1.3 Global Nootropics Brain Supplements Market Size by Type1.3.1 Global Nootropics Brain Supplements Market Size Overview by Type (2016-2027)1.3.2 Global Nootropics Brain Supplements Historic Market Size Review by Type (2016-2021)

1.3.2.1 Global Nootropics Brain Supplements Sales Breakdown in Volume by Type (2016-2021)

1.3.2.2 Global Nootropics Brain Supplements Sales Breakdown in Value by Type (2016-2021)

1.3.2.3 Global Nootropics Brain Supplements Average Selling Price (ASP) by Type (2016-2021)1.3.3 Global Nootropics Brain Supplements Forecasted Market Size by Type (2022-2027)

1.3.3.1 Global Nootropics Brain Supplements Sales Breakdown in Volume by Type (2022-2027)

1.3.3.2 Global Nootropics Brain Supplements Sales Breakdown in Value by Type (2022-2027)

1.3.3.3 Global Nootropics Brain Supplements Average Selling Price (ASP) by Type (2022-2027)1.4 Key Regions Market Size Segment by Type1.4.1 North America Nootropics Brain Supplements Sales Breakdown by Type (2016-2021)1.4.2 Europe Nootropics Brain Supplements Sales Breakdown by Type (2016-2021)1.4.3 Asia-Pacific Nootropics Brain Supplements Sales Breakdown by Type (2016-2021)1.4.4 Latin America Nootropics Brain Supplements Sales Breakdown by Type (2016-2021)1.4.5 Middle East and Africa Nootropics Brain Supplements Sales Breakdown by Type (2016-2021) 2 Global Nootropics Brain Supplements Market Competition by Company2.1 Global Top Players by Nootropics Brain Supplements Sales (2016-2021)2.2 Global Top Players by Nootropics Brain Supplements Revenue (2016-2021)2.3 Global Top Players Nootropics Brain Supplements Price (2016-2021)2.4 Global Top Manufacturers Nootropics Brain Supplements Manufacturing Base Distribution, Sales Area, Product Type2.5 Nootropics Brain Supplements Market Competitive Situation and Trends2.5.1 Nootropics Brain Supplements Market Concentration Rate (2016-2021)2.5.2 Global 5 and 10 Largest Manufacturers by Nootropics Brain Supplements Sales and Revenue in 20202.6 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) & (based on the Revenue in Nootropics Brain Supplements as of 2020)2.7 Date of Key Manufacturers Enter into Nootropics Brain Supplements Market2.8 Key Manufacturers Nootropics Brain Supplements Product Offered2.9 Mergers & Acquisitions, Expansion 3 Nootropics Brain Supplements Status and Outlook by Region3.1 Global Nootropics Brain Supplements Market Size and CAGR by Region: 2016 VS 2021 VS 20263.2 Global Nootropics Brain Supplements Historic Market Size by Region3.2.1 Global Nootropics Brain Supplements Sales in Volume by Region (2016-2021)3.2.2 Global Nootropics Brain Supplements Sales in Value by Region (2016-2021)3.2.3 Global Nootropics Brain Supplements Sales (Volume & Value) Price and Gross Margin (2016-2021)3.3 Global Nootropics Brain Supplements Forecasted Market Size by Region3.3.1 Global Nootropics Brain Supplements Sales in Volume by Region (2022-2027)3.3.2 Global Nootropics Brain Supplements Sales in Value by Region (2022-2027)3.3.3 Global Nootropics Brain Supplements Sales (Volume & Value), Price and Gross Margin (2022-2027) 4 Global Nootropics Brain Supplements by Application4.1 Nootropics Brain Supplements Market Segment by Application4.1.1 Students4.1.2 Athletes4.1.3 Older Adults4.1.4 Others4.2 Global Nootropics Brain Supplements Market Size by Application4.2.1 Global Nootropics Brain Supplements Market Size Overview by Application (2016-2027)4.2.2 Global Nootropics Brain Supplements Historic Market Size Review by Application (2016-2021)

4.2.2.1 Global Nootropics Brain Supplements Sales Breakdown in Volume, by Application (2016-2021)

4.2.2.2 Global Nootropics Brain Supplements Sales Breakdown in Value, by Application (2016-2021)

4.2.2.3 Global Nootropics Brain Supplements Average Selling Price (ASP) by Application (2016-2021)4.2.3 Global Nootropics Brain Supplements Forecasted Market Size by Application (2022-2027)

4.2.3.1 Global Nootropics Brain Supplements Sales Breakdown in Volume, by Application (2022-2027)

4.2.3.2 Global Nootropics Brain Supplements Sales Breakdown in Value, by Application (2022-2027)

4.2.3.3 Global Nootropics Brain Supplements Average Selling Price (ASP) by Application (2022-2027)4.3 Key Regions Market Size Segment by Application4.3.1 North America Nootropics Brain Supplements Sales Breakdown by Application (2016-2021)4.3.2 Europe Nootropics Brain Supplements Sales Breakdown by Application (2016-2021)4.3.3 Asia-Pacific Nootropics Brain Supplements Sales Breakdown by Application (2016-2021)4.3.4 Latin America Nootropics Brain Supplements Sales Breakdown by Application (2016-2021)4.3.5 Middle East and Africa Nootropics Brain Supplements Sales Breakdown by Application (2016-2021) 5 North America Nootropics Brain Supplements by Country5.1 North America Nootropics Brain Supplements Historic Market Size by Country5.1.1 North America Nootropics Brain Supplements Sales in Volume by Country (2016-2021)5.1.2 North America Nootropics Brain Supplements Sales in Value by Country (2016-2021)5.2 North America Nootropics Brain Supplements Forecasted Market Size by Country5.2.1 North America Nootropics Brain Supplements Sales in Volume by Country (2022-2027)5.2.2 North America Nootropics Brain Supplements Sales in Value by Country (2022-2027) 6 Europe Nootropics Brain Supplements by Country6.1 Europe Nootropics Brain Supplements Historic Market Size by Country6.1.1 Europe Nootropics Brain Supplements Sales in Volume by Country (2016-2021)6.1.2 Europe Nootropics Brain Supplements Sales in Value by Country (2016-2021)6.2 Europe Nootropics Brain Supplements Forecasted Market Size by Country6.2.1 Europe Nootropics Brain Supplements Sales in Volume by Country (2022-2027)6.2.2 Europe Nootropics Brain Supplements Sales in Value by Country (2022-2027) 7 Asia-Pacific Nootropics Brain Supplements by Region7.1 Asia-Pacific Nootropics Brain Supplements Historic Market Size by Region7.1.1 Asia-Pacific Nootropics Brain Supplements Sales in Volume by Region (2016-2021)7.1.2 Asia-Pacific Nootropics Brain Supplements Sales in Value by Region (2016-2021)7.2 Asia-Pacific Nootropics Brain Supplements Forecasted Market Size by Region7.2.1 Asia-Pacific Nootropics Brain Supplements Sales in Volume by Region (2022-2027)7.2.2 Asia-Pacific Nootropics Brain Supplements Sales in Value by Region (2022-2027) 8 Latin America Nootropics Brain Supplements by Country8.1 Latin America Nootropics Brain Supplements Historic Market Size by Country8.1.1 Latin America Nootropics Brain Supplements Sales in Volume by Country (2016-2021)8.1.2 Latin America Nootropics Brain Supplements Sales in Value by Country (2016-2021)8.2 Latin America Nootropics Brain Supplements Forecasted Market Size by Country8.2.1 Latin America Nootropics Brain Supplements Sales in Volume by Country (2022-2027)8.2.2 Latin America Nootropics Brain Supplements Sales in Value by Country (2022-2027) 9 Middle East and Africa Nootropics Brain Supplements by Country9.1 Middle East and Africa Nootropics Brain Supplements Historic Market Size by Country9.1.1 Middle East and Africa Nootropics Brain Supplements Sales in Volume by Country (2016-2021)9.1.2 Middle East and Africa Nootropics Brain Supplements Sales in Value by Country (2016-2021)9.2 Middle East and Africa Nootropics Brain Supplements Forecasted Market Size by Country9.2.1 Middle East and Africa Nootropics Brain Supplements Sales in Volume by Country (2022-2027)9.2.2 Middle East and Africa Nootropics Brain Supplements Sales in Value by Country (2022-2027) 10 Company Profiles and Key Figures in Nootropics Brain Supplements Business10.1 NOOESIS10.1.1 NOOESIS Corporation Information10.1.2 NOOESIS Introduction and Business Overview10.1.3 NOOESIS Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.1.4 NOOESIS Nootropics Brain Supplements Products Offered10.1.5 NOOESIS Recent Development10.2 Excelerol10.2.1 Excelerol Corporation Information10.2.2 Excelerol Introduction and Business Overview10.2.3 Excelerol Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.2.4 NOOESIS Nootropics Brain Supplements Products Offered10.2.5 Excelerol Recent Development10.3 Zhou Nutrition10.3.1 Zhou Nutrition Corporation Information10.3.2 Zhou Nutrition Introduction and Business Overview10.3.3 Zhou Nutrition Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.3.4 Zhou Nutrition Nootropics Brain Supplements Products Offered10.3.5 Zhou Nutrition Recent Development10.4 Neurofuse10.4.1 Neurofuse Corporation Information10.4.2 Neurofuse Introduction and Business Overview10.4.3 Neurofuse Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.4.4 Neurofuse Nootropics Brain Supplements Products Offered10.4.5 Neurofuse Recent Development10.5 LFI Labs10.5.1 LFI Labs Corporation Information10.5.2 LFI Labs Introduction and Business Overview10.5.3 LFI Labs Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.5.4 LFI Labs Nootropics Brain Supplements Products Offered10.5.5 LFI Labs Recent Development10.6 Opti-Nutra LTD.10.6.1 Opti-Nutra LTD. Corporation Information10.6.2 Opti-Nutra LTD. Introduction and Business Overview10.6.3 Opti-Nutra LTD. Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.6.4 Opti-Nutra LTD. Nootropics Brain Supplements Products Offered10.6.5 Opti-Nutra LTD. Recent Development10.7 Onnit10.7.1 Onnit Corporation Information10.7.2 Onnit Introduction and Business Overview10.7.3 Onnit Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.7.4 Onnit Nootropics Brain Supplements Products Offered10.7.5 Onnit Recent Development10.8 Synergy10.8.1 Synergy Corporation Information10.8.2 Synergy Introduction and Business Overview10.8.3 Synergy Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.8.4 Synergy Nootropics Brain Supplements Products Offered10.8.5 Synergy Recent Development10.9 Cognetix Labs10.9.1 Cognetix Labs Corporation Information10.9.2 Cognetix Labs Introduction and Business Overview10.9.3 Cognetix Labs Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.9.4 Cognetix Labs Nootropics Brain Supplements Products Offered10.9.5 Cognetix Labs Recent Development10.10 AlternaScript10.10.1 Company Basic Information, Manufacturing Base and Competitors10.10.2 Nootropics Brain Supplements Product Category, Application and Specification10.10.3 AlternaScript Nootropics Brain Supplements Sales, Revenue, Price and Gross Margin (2016-2021)10.10.4 Main Business Overview10.10.5 AlternaScript Recent Development10.11 Nootrostax10.11.1 Nootrostax Corporation Information10.11.2 Nootrostax Introduction and Business Overview10.11.3 Nootrostax Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.11.4 Nootrostax Nootropics Brain Supplements Products Offered10.11.5 Nootrostax Recent Development10.12 Neurohacker Collective10.12.1 Neurohacker Collective Corporation Information10.12.2 Neurohacker Collective Introduction and Business Overview10.12.3 Neurohacker Collective Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.12.4 Neurohacker Collective Nootropics Brain Supplements Products Offered10.12.5 Neurohacker Collective Recent Development10.13 Mind Lab Pro10.13.1 Mind Lab Pro Corporation Information10.13.2 Mind Lab Pro Introduction and Business Overview10.13.3 Mind Lab Pro Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.13.4 Mind Lab Pro Nootropics Brain Supplements Products Offered10.13.5 Mind Lab Pro Recent Development10.14 CILTEP10.14.1 CILTEP Corporation Information10.14.2 CILTEP Introduction and Business Overview10.14.3 CILTEP Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.14.4 CILTEP Nootropics Brain Supplements Products Offered10.14.5 CILTEP Recent Development10.15 Nooflux10.15.1 Nooflux Corporation Information10.15.2 Nooflux Introduction and Business Overview10.15.3 Nooflux Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.15.4 Nooflux Nootropics Brain Supplements Products Offered10.15.5 Nooflux Recent Development10.16 EVO-X10.16.1 EVO-X Corporation Information10.16.2 EVO-X Introduction and Business Overview10.16.3 EVO-X Nootropics Brain Supplements Sales, Revenue and Gross Margin (2016-2021)10.16.4 EVO-X Nootropics Brain Supplements Products Offered10.16.5 EVO-X Recent Development 11 Upstream, Opportunities, Challenges, Risks and Influences Factors Analysis11.1 Nootropics Brain Supplements Key Raw Materials11.1.1 Key Raw Materials11.1.2 Key Raw Materials Price11.1.3 Raw Materials Key Suppliers11.2 Manufacturing Cost Structure11.2.1 Raw Materials11.2.2 Labor Cost11.2.3 Manufacturing Expenses11.3 Nootropics Brain Supplements Industrial Chain Analysis11.4 Nootropics Brain Supplements Market Dynamics11.4.1 Industry Trends11.4.2 Market Drivers11.4.3 Market Challenges11.4.4 Market Restraints 12 Market Strategy Analysis, Distributors12.1 Sales Channel12.2 Nootropics Brain Supplements Distributors12.3 Nootropics Brain Supplements Downstream Customers 13 Research Findings and Conclusion 14 Appendix14.1 Research Methodology14.1.1 Methodology/Research Approach

14.1.1.1 Research Programs/Design

14.1.1.2 Market Size Estimation

14.1.1.3 Market Breakdown and Data Triangulation14.1.2 Data Source

14.1.2.1 Secondary Sources

14.1.2.2 Primary Sources14.2 Author Details14.3 Disclaimer

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Nootropics Brain Supplements Market 2021 2027 | Growth Dynamics, Revenue Outlook and Opportunities Forecast Excelerol, Zhou Nutrition, Neurofuse The...

Gus Kenworthy Joins beam as Global Athlete and Wellness Ambassador and Investor – PRNewswire

"As a busy athlete training for the 2022 Winter Olympics my schedule is stacked with training, traveling and balancing career demands. Rest and recovery are essential to optimize performance as I continue to push my own physical limits," said Gus Kenworthy, two-time Olympic Skier and Olympic Silver Medalist. "beam's recovery and sleep lines are vital to that process and, now as an investor, I can support their mission to improve physical and mental wellness by prioritizing rest and recovery in a culture that glorifies overworking ourselves."

Kenworthy joins a world class roster of high-performing athletes and Olympians working with beam alongside two-time CrossFit champion, Katrn Davsdttir; Olympic Gold-medalist, Gwen Jorgensen; and 2021 Summer Olympian, Molly Seidel. The brand's organic growth has been accelerated by their athlete ambassador network, counting Danica Patrick, Baker Mayfield, Billy Horschel and Mat Fraser within their tribe as brand evangelists and agents.

"Gus joining our roster of athlete ambassadors will continue our mission to diversify our partners that are at the top of their sport. We pride ourselves in partnerships that happen organically -- beam is committed to working with community leaders that truly use our products to enhance their overall wellness," said Kevin Moran and Matt Lombardi, co-founders of beam.

Not only is Gus gearing up for his debut on Great Britain's team in the 2022 Winter Olympics, he has secured a spot on NBC's on-air talent roster to cover the 2021 Summer Olympics in Tokyo. Kenworthy's alignment with beam naturally assists him to find balance for an array of upcoming projects for this year, in addition to continuing his support of a variety of humanitarian causes.

beam gives backCore to beam's philosophy is to align with and support organizations working to make positive change in the world. In alignment with the partnership and Pride Month, beam will donate 1% of net sales from the month of June to Greater Boston PFLAG. Greater Boston PFLAG (GBPFLAG) works to create environments of understanding so that all people can live with dignity and respect through support, education, and advocacy. GBPFLAG provides opportunities for dialogue about sexual orientation and gender identity, and acts to create a society that is healthy and respectful of human diversity. For more information about beam's give back initiatives visit beam gives back.

To download hi-res images click HERE.

ABOUT BEAMFounded by former professional athletes, beam is a Boston-based wellness company with a mission to help people experience what better feels like through all-natural functional products that use rigorously-tested THC-free CBD, adaptogens, nootropics and electrolytes. The company was recently honored by Inc. as one of the Best Workplaces for 2021. For more information visit beamtlc.com.

ABOUT GREATER BOSTON PFLAGGreater Boston PFLAG works to create environments of understanding so that all people can live with dignity and respect through support, education, and advocacy. GBPFLAG provides opportunities for dialogue about sexual orientation and gender identity, and acts to create a society that is healthy and respectful of human diversity. For more information about Greater Boston PFLAG call 781.891.5966, find us on Twitter, Facebook or Instagram @GBPFLAG or visit http://www.gbpflag.org.

MEDIA CONTACTJack Taylor PRMorgan Kilmer[emailprotected] 816-868-5229

SOURCE beam

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Gus Kenworthy Joins beam as Global Athlete and Wellness Ambassador and Investor - PRNewswire

As blockchain becomes widely used in banking, what are its security risks? – Forkast News

Today, everybody understands the importance of investing in technology and the surplus returns it brings. Blockchain is currently one of the hottest technologies on the market.

Not only have investors made their fair share of investments in blockchain for the first time ever, but investment banks also now issue bonds using this technology.

Blockchain technology is a form of decentralized database that stores information in blocks that are chained together. It computes, stores and analyzes data stored in this database and functions differently from the traditional centralized database in very specific ways.

Blockchain is decentralized because no single individual controls the information within the database or network. It is accessible to anyone around the world to command or access.

Every piece of information sent into it is stored in a new block until that block is filled with data. Then it is chained to the preceding block to link them chronologically.

It is mainly used as a ledger for transactions because every bit of information sent to it can never be erased or tampered with, making it a transparent platform for carrying out payments.

For cryptocurrency, blockchain is used in a decentralized way so that no single individual can have control over the information about cryptocurrency that is being inputted into the network. The data is permanently recorded and viewable by all.

Blockchain technology in the banking and finance sector is becoming paramount and sought-after now because of the benefits and opportunities it presents.

But as the digital world expands and evolves, cybercriminals are also developing new tools to remove blocks from their way. This is why banks have seen the need to be a step ahead of the game.

With blockchain technology, disbursing and receiving funds becomes decentralized. This spells a lot of things for the banking industry:

There is a reduction in fraudulent crimes and activities because the decentralized database is less susceptible to data breaches, hacking or the figures tampered with. This also means a more transparent system of banking too.

Blockchain technology spells an improvement in the speed at which banks will send payments since it runs on real-time payment executions.

It is also helpful for spotting foul play in banking activities and quickly identifying criminal dealings.

Blockchain also ensures there are little to no human errors because the information sent to the blockchain cannot be erased, modified or tampered with. It is also available for everyone to see.

Banks have steadily started to integrate blockchain technology into some of their processes. We see the first of its kind in investment banking, with the European Investment Bank (EIB).

In April 2021, EIB further stamped the interests of the capital market in bringing in blockchain technology in its processes when it registered a two-year digital bond in the public Ethereum blockchain network.

This action was welcomed with a -0.601% yield, sending Ether, one of the worlds largest cryptocurrencies, to a record high. This digital bond yielded over US$120 million (100 million euros), which the funding officials at the bank confirmed to be the first time it was making such a sale.

Of course, this move indicates many things for the capital market and its investment processes.

Blockchain comes on the capital market to make the issuance of bonds and other securities smoother and more convenient. Although blockchain was initially created for decentralizing Bitcoin, capital market players are starting to see it as the solution to the capital markets challenges.

Before now, raising capital in the market traditionally was not only expensive but tedious and yielded only little results. With blockchain, it is obvious there would be a turnaround in the capital market. Blockchain would boost transparency of the bonds and securities issuance process and still reduce expenses and time.

Officials at the EIB believe that the introduction of blockchain technology and its benefits are a game changer for the capital market.

However, fully adopting and switching to this technology has not been the easiest, seeing as the EIB has devoted a lot of work and effort since 2019 to put in the issuance.

Surely, blockchain takes care of the many risks of fraud and criminal activities in the banking industry, but what risks do using blockchain technology pose for the industry?

While blockchain technology may be the future of investment banking and other finance industry sectors, it remains pertinent not to discard the cybersecurity risks it may present. Adequate preparation to prevent these risks is vital to avoid colossal loss of securities for investors and shareholders.

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As blockchain becomes widely used in banking, what are its security risks? - Forkast News

Nvidia CEO Jensen Huang weighs in on the metaverse, blockchain, and chip shortage – VentureBeat

Elevate your enterprise data technology and strategy at Transform 2021.

Conversations with Nvidia CEO Jensen Huang are always blunt and illuminating because he still likes to have freewheeling chats with the press. During the recent online-only Computex event, he held a briefing with the press where he talked about the companys recent announcements and then took a lot of questions.

I asked him about the metaverse, the universe of virtual worlds that are all interconnected, like in novels such asSnow CrashandReady Player One. And he gave a detailed answer. Huang addressed a wide range of issues. He talked about Nvidias pending bid to buy Arm for $40 billion, as well as Nvidias effort to create Grace, an Arm-based CPU.

He also addressed progress on Nvidias own Omniverse, dubbed a metaverse for engineers. Huang talked about Nvidias presence in the Chinese market, the companys efforts to discourage miners from buying all of its GPUs, Nvidias data processing units (DPUs), and Moores Laws future and building fabs, competition from Advanced Micro Devices in graphics processing units (GPUs), and Nvidias reaction to the global semiconductor shortage.

I was part of a group of journalists who quizzed Huang. Heres an edited transcript of the group interview.

Above: Nvidia GeForce RTX 3080 Ti is its new card.

Image Credit: GamesBeat

Jensen Huang: Today Im coming to you from Nvidias new building, called Voyager. This is our new facility. It was started about 2-and-a-half years ago. For the last year-and-a-half, Ive not seen it. Todays my first day on campus. Literally, for our event today, this is my first day on campus. Its beautiful here. This facility is going to be the home of 3,500 Nvidians. Its designed as a city inside a building. If you look behind me, its a sprawling city, and its a very large open space. Its largely naturally lit. In fact, right now, as we speak, theres a light in front of me, but everything behind us is barely lit. The reason for that is because there are all these panels in the sky that let light in.

We simulated this entire building using raytracing on our supercomputer DGX. The reason we did that is so we can balance the amount of light that comes in and the amount of energy, or otherwise heat, that we have to remove with air conditioning. The more light you bring in, the more AC you have to use. The less light you bring in, the more lighting you have to use. We have to simulate that fine balance.

The roof of this building is angled in just the right way such that the morning sun doesnt come straight in, and the afternoon sun doesnt come straight in. The slope of the roof line, the slope of the windows along the side, youll see everything was designed in such a way as to balance between natural light, which is comfortable for the eyes, and not having to use as much air conditioning as otherwise necessary. At the moment, no AC at all. This is the first day weve been in here. Its incredibly comfortable.

Using a supercomputer to simulate architecture, I think this is going to happen for all buildings in the future. Youre going to design a building completely in virtual reality. The building is also designed to accommodate many robots. Youll notice the hallways are very wide. In the future we imagine robots roaming the hallways carrying things to people, but also for telepresence, virtual presence. You can upload yourself into a robot and sit at your desk in your VR or AR headset and roam around the campus.

Youre the first in the world to be here. Welcome all of you, and I thank you for joining me today. I also want to send my thoughts and recognize that in Taiwan, COVID cases are growing again. Im very sorry about that. I hope all of you are safe. I know that Taiwan was so rigorous in keeping the infection rates down, and so Im terribly sorry to see it go up now. I know they can get it under control, and soon all of us will be able to see each other in person.

Let me say a couple of words about the announcement. We announced two basic things. In GeForce gaming, where Taiwan is the central hub of where our add-in card partners and many of our leading laptop partners are based, and the home of, the epicenter if you will, the GeForce ecosystem. It all starts there. Its manufactured and assembled and integrated, and it goes to the market through our add-in card partners and laptop builders.

Above: Nvidias RTX is used in more than 130 games.

Image Credit: Nvidia

The GeForce business is doing incredibly well. The invention of RTX has been a home run. It has reset and redefined computer graphics, completely reinvented modern computer graphics. Its a journey that started more than 10 years ago, and a dream that started 35 years ago. It took that long for us to invent the possibility of doing real-time raytracing, which is really hard to do. It wasnt until we were able to fuse our hardware accelerated raytracing core with the Tensor core GPU, AI processing, and a bunch of new rendering algorithms, that we were able to bring real-time raytracing to reality. RTX has reinvented computer graphics in the marketplace. RTX 30, the 30 family, the Ampere architecture family, has been fantastic.

We announced several things. We announced that we upgraded the RTX 30 family with the 3080Ti and the 3070Ti. Its our regularly planned once per year upgrade to our high end GPUs. We also, with the partnership with all of our laptop partners, our AICs, launched 140 different laptops. Our laptop business is one of the fastest growing businesses in our company. This year we have twice as many notebooks going into the marketplace as we did with Turing, our last generation, RTX 20. This is one of the fastest growing businesses. The laptop business is the fastest growing segment of PCs. Nvidia laptops are growing at seven times the rate of the overall laptop business. It gives a sense of how fast RTX laptops are growing.

If you think about RTX laptops as a game console, its the largest game console in the world. There are more RTX laptops shipped each year than game consoles. If you were to compare the performance of a game console to an RTX, even an RTX 3060 would be 30-50% faster than a PlayStation 5. We have a game console, literally, in this little thin notebook, which is one of the reasons its selling so well. The same laptop also brings with it all of the software stacks and rendering stacks necessary for design applications, like Adobe and Autodesk and all of these wonderful design and creative tools. The RTX laptop, RTX 3080Ti, RTX 3070Ti, and a whole bunch of new games, that was one major announcement.

The second thrust is enterprise, datacenters. As you know, AI is software that can write software. Using machines you can write software that no human possibly can. It can learn from an enormous amount of data using an algorithm in an approach called deep learning. Deep learning isnt just one algorithm. Deep learning is a whole bunch of algorithms. Some for image recognition, some for recognizing 2D to 3D, some for recognizing sequences, some for reinforcement learning in robotics. Theres a whole bunch of different algorithms that are associated with deep learning. But theres no question that we can now write software that weve not been able to write before. We can automate a bunch of things that we never thought would be possible in our generation.

One of the most important things is natural language understanding. Its now so good that you can summarize an entire chapter of a book, or the whole book. Pretty soon you can summarize a movie. Watch the movie, listen to the words, and summarize it in a wonderful way. You can have questions and answers with an NLU model.

AI has made tremendous breakthroughs, but has largely been used by the internet companies, the cloud service providers and internet services. What we announced at GTC initially a few weeks ago, and then what we announced at Computex, is a brand new platform thats called Nvidia Certified AI for Enterprise. Nvidia Certified systems running a software stack we call Nvidia AI Enterprise. The software stack makes it possible to achieve world class capabilities in AI with a bunch of tools and pre-trained AI models. A pre-trained AI model is like a new college grad. They got a bunch of education. Theyre trained. But you have to adapt them into your job and to your profession, your industry. But theyre pre-trained and really smart. Theyre smart at image recognition, at language understanding, and so on.

We have this Nvidia AI Enterprise that sits on top of a body of work that we collaborated on with VMware. That sits on top of Nvidia Certified servers from the worlds leading computer makers, many of them in Taiwan, all over the world, and these are high-volume servers that incorporate our Ampere generation datacenter GPUs and our Mellanox BlueField DPUs. This whole stack gives you a cloud native its like having an AI cloud, but its in your company. It comes with a bunch of tools and capabilities for you to be able to adapt it.

How would you use it? Health care would use it for image recognition in radiology, for example. Retail will use it for automatic checkout. Warehouses and logistics, moving products, tracking inventory automatically. Cities would use these to monitor traffic. Airports would use it in case someone lost baggage, it could instantly find it. There are all kinds of applications for AI in enterprises. I expect enterprise AI, what some people call the industrial edge, will be the largest opportunity of all. Itll be the largest AI opportunity.

With the overall trend, what all of these announcements show is that Nvidia accelerated computing is gaining momentum. We had our company grow a lot last year, as many of you know. This last quarter we had a record quarter across all our product lines. We expect the next quarter to be another great quarter, and the second half also to be a great growth second half. Its very clear that the world of computing is changing, that accelerated computing is making a contribution, and one of the most important applications is AI.

Above: BMW Group is using Nvidias Omniverse to build a digital factory that will mirror a real-world place.

Image Credit: Nvidia

Question: I wonder about your latest thoughts on the metaverse and how were making progress toward that. Do you see steps happening in the process of creating the metaverse?

Huang: Youve been talking about the metaverse for some time, and youve had interest in this area for a long time. I believe were right on the cusp of it. The metaverse, as you know, for all of you who are learning about it and hearing about it, its a virtual world that connects to the world that we live in. Its a virtual world that is shared by a lot of people. It has real design. It has a real economy. You have a real avatar. That avatar belongs to you and is you. It could be a photoreal avatar of you, or a character.

In these metaverses, youll spend time with your friends. Youll communicate, for example. We could be, in the future, in a metaverse right now. It will be a communications metaverse. It wont be flat. Itll be 3D. Well be able to almost feel like were there with each other. Its how we do time travel. Its how we travel to far places at the speed of light. It could simulate the future. There will be many types of metaverses, and video games are one of them, for example. Fortnite will eventually evolve into a form of metaverse, or some derivative of it. World of Warcraft, you can imagine, will someday evolve into a form of metaverse. There will be video game versions.

There will be AR versions, where the art that you have is a digital art. You own it using NFT. Youll display that beautiful art, thats one of a kind, and its completely digital. Youll have our glasses on or your phone. You can see that its sitting right there, perfectly lit, and it belongs to you. Well see this overlay, a metaverse overlay if you will, into our physical world.

In the world of industry, the example I was giving earlier, this building exists fully in virtual reality. This building completely exists in VR. We designed it completely digitally. Were going to build it out so that there will be a digital twin of this very physical building in VR. Well be able to simulate everything, train our robots in it. We can simulate how best to distribute the air conditioning to reduce the energy consumption. Design certain shapeshifting mechanisms that block sunlight while letting in as much light as possible. We can simulate all of that in our digital twin, our building metaverse, before we deploy anything here in the physical world. Well be able to go in and out of it using VR and AR.

Those are all pieces that have to come together. One of the most important technologies that we have to build, for several of them in the case of consumers, one of the important technologies is AR, and its coming along. AR is important. VR is becoming more accessible and easier to use. Its coming along. In the case of the industrial metaverse, one of the most important technologies is physically based, physically simulated VR environments. An object that you design in the metaverse, if you drop it to the ground, itll fall to the ground, because it obeys the laws of physics. The lighting condition will be exactly as we see. Materials will be simulated physically.

These things are essential components of it, and thats the reason why we invented the Nvidia Omniverse. If you havent had a chance to look at it, its so important. Its one of our most important bodies of work. It combines almost everything that Nvidia has ever built. Omniverse is now in open beta. Its being tested by 400 companies around the world. Its used at BMW to create a digital factory. Its used by WPP, the worlds largest advertising agency. Its used by large simulation architects. Bentley, the worlds largest designer of large infrastructure, they just announced that theyll use Omniverse to create digital twins. Omniverse is very important work, and its worth taking a look at.

Above: Nvidia GeForce RTX 3080 Ti graphics card.

Image Credit: Nvidia

Question: You mentioned the opportunities ahead of Nvidia. The recent trend in China is that China has seen a lot of GPU startups emerge in the last one or two years. Its received billions in funding from VCs. China has a lot of reasons to develop its own Nvidia in the next few years. Are you concerned that your Chinese customers are hoping to develop a rival for you in this market?

Huang: Weve had competition, intense competition, from companies that are gigantic, since the founding of our company. What we need to do is we need to make sure we continue to run very fast. Our company is able to invest, in a couple of years, which is one generation, $10 billion to do one thing. After investing in it for 30 years. We have a great deal of expertise and scale. We have the ability to invest greatly. We care deeply about this marketplace. Were going to continue to run very fast. Our companys position, of course, is not certain. We have to take all of the competition, respect them, and take them seriously, and recognize that there are many places where you could contribute to AI. We just have to keep on running hard.

However, heres my prediction. Every datacenter and every server will be accelerated. The GPU is the ideal accelerator for these general purpose applications. There will be hundreds of millions of datacenters. Not just 100 datacenters or 1,000 datacenters, but 100 million. The datacenters will be in retail stores, in 5G base stations, in warehouses, in schools and banks and airports. Theyll be everywhere. Street corners. They will all be datacenters. The market opportunity is quite large. This is the largest market opportunity the IT industry has ever seen. I can understand why it inspires so many competitors. We just need to continue to do our best work and run as fast as we can.

Question: Are you also worried about the government interfering in this space?

Huang: I believe that we add value to the marketplace. Nvidias position in China, and our contribution to China, is good. It has helped the internet companies, helped many startups, helped researchers developing AI. Its wonderful for the gaming business and the design business. We make a lot of contributions to the IT ecosystem in China. I think the government recognizes that. My sense is that were welcome in China and well continue to work hard to deserve to be welcome in China, and every other country for that matter. Well do that.

Above: Nvidias GeForce RTX 3050 will power new laptops.

Image Credit: Nvidia

Question: Weve seen a few keynotes about games, and weve seen more and more Chinese games, games developed by Chinese companies. How do you position or commend Chinese developers? What does Nvidia plan to do to support the Chinese gaming ecosystem?

Huang: We do several things that developers love. The first thing is our installed base is very big. If youre a developer and you develop on Nvidias platform, because all of our platform, all of our GeForce, are compatible we work so hard to make sure that all of the software is high quality. We maintain and continue to update the software, to keep tuning every single GPU for every game. Every GPU, every game, were constantly tuning. We have a large group of engineers constantly studying and looking for ways to improve. We use our platform called GeForce Experience to update the software for the gamer.

The first thing is our installed base is very large, then. Our software quality is very good. But very important, one of the things that content developers, game developers love is our expertise in computer graphics, working with them to bring beautiful graphics to their games is excellent. Weve invented so many algorithms. We invented programmable shading, as you know. This is almost 20 years ago, we invented the programmable pixel and vertex shaders in the GPU. We invented RTX. We teach people how to use programmable shading to create special effects, how to use RTX to create raytracing and ambient occlusion and global illumination, really beautiful computer graphics. We have a lot of expertise and a lot of technology that we can use to work with gamers to incorporate that into their games so that theyre as beautiful as possible.

When its done, we have fantastic marketing. We have such a large reach, we can help the developers promote their games all over the world. Many of the Chinese developers would like to reach the rest of the world, because their games are now triple-A quality, and they should be able to go all over the world. There are several reasons why game developers enjoy working with us, and those are the reasons.

Above: Nvidias Grace CPU for datacenters is named after Grace Hopper.

Image Credit: Nvidia

Question: At GTC you announced Grace, which seems like a big project. An Arm CPU is hard to implement. Do you think Arm can overtake the x86 processor in the server market in the future?

Huang: First of all, I think the future world is very diversified. It will be x86. It will be Arm. It will be big CPUs, small CPUs, edge CPUs, datacenter CPUs, supercomputing CPUs, enterprise computing CPUs, lots of CPUs. I think the world is very diversified. There is no one answer.

Our strategy is one where well continue to support the x86 CPUs in the markets we serve. We dont serve every market. We serve high-performance computing. We serve AI. We serve computer graphics. We serve the markets that we serve. For the markets that we serve, not every CPU is perfect, but some CPUs are quite ideal. Depending on the market, and depending on the application, the computing requirements, we will use the right CPU.

Sometimes the right CPU is Intel x86. For example, we have 140 laptops. The vast majority of them are Intel CPUs. We have DGX systems. We need a lot of PCI Express. It was great to use the AMD CPU. In the case of 5G base stations, Marvells CPU is ideal. Theyre based on Arm. Cloud hyperscale, Ampere Computings Altra CPU is excellent. Graviton 2 is excellent. Its fantastic. We support those. In Japan, Fujitsus CPU is incredible for supercomputing. Well support that. Different types of CPUs are designed for different applications.

The CPU we designed has never been designed before. No CPU has ever been able to achieve the level of memory bandwidth and memory capacity that we have designed for. It is designed for big data analytics. Its designed for the state of the art in AI. There are two primary models, or AI models, that we are very interested in advancing, because theyre so important. The first one is the recommender system. Its the most valuable piece of software, approach of software, that the world has ever known. It drives all the internet companies, all the internet services. The recommender system is very important, incredibly important science. Its designed for that. The second is natural language understanding, which requires a lot of memory, a lot of data, to train a very smart AI for having conversational AI, answering questions, making recommendations, and so on.

These two models are probably, my estimation, the most valuable software in the world today. It requires a very large machine. We decided that we would design something just for those types of applications, where big AI is necessary. Meanwhile, there are so many different markets and edges and enterprises and this and that. Well support the CPUs that are right for them. I believe the future is about diversity. I believe the future is about variability and customization and those kinds of things. Arm is a great strategy for us, and x86 will remain a great strategy for us.

Above: Simon Segars is CEO of Arm.

Image Credit: Arm

Question: You recently had the earnings call where you talked a bit about the Arm deal, and Simon Segars keynote mentioned it as well, that hes looking forward to the deal, combining their ecosystem plus all the AI capabilities of Nvidia. Is there any update about the next steps for you guys?

Huang: Were going through the regulatory approval. It takes about 18 months. The process typically goes U.S., then the EC, and then China last. Thats the typical journey. Mellanox took about 18 months, or close to it. I expect this one to take about 18 months. That makes it early next year, or late this year.

Im confident about the transaction. The regulators are looking for, is this good for competition? Is it pro-competitive? Does it bring innovation to the market? Does it give customers more choice? Does it give customers more offerings and more choice? You can see that on first principles, because our companies are completely complementary they build CPUs, we build GPUs and DPUs. They dont build GPUs. Our companies are complementary, and so by nature well bring innovations that come as a result of coming together offering complementary things. Its like ketchup and mustard coming together. Its good for innovation.

Question: You mentioned that the acquisition will increase competition. Can you explain which areas you see for future competition? We see that AMD and also other players are starting to compete in GPUs, CPUs, and datacenters.

Huang: First of all, its pro-competitive because it brings customers more choice. If we combine Nvidia and Arm, Arms R&D scale will be much larger. As you know, Arm is a big company. Its not a small company. But Nvidia is much bigger. Our R&D budget is many times larger than Arms. Our combination will give them more R&D scale. It will give them technology that they dont have the ability to build themselves, or the scale to build themselves, like all of the AI expertise that we have. We can bring those capabilities to Arm and to its market.

As a result of that, we will offer Arm customers more technology choice, better technology, more advanced technology. That ultimately is great for competition, because it allows Arms licensees to create even better products, more vibrant products, better leading-edge technology, which in the end market will give the end market more choice. Thats ultimately the fundamental reason for competition. Its customer choice. More vibrant innovation, more R&D scale, more R&D expertise brings customers more choice. That, I think, is at the core of it.

For us, it brings us a very large ecosystem of developers, which Nvidia as a company, because were an accelerated computing company developers drive our business. And so with 15 million more developers we have more than 30 million developers today those 15 million developers will develop new software that ultimately will create value for our company. Our technology, through their channel, creates value for their company. The combination is a win-win.

Above: Jensen Huang of Nvidia stands in a virtual environment.

Image Credit: Nvidia

Question: Im interested in your personal thoughts on the weve had all the supply chain constraints on one hand, and then on the other hand a demand surplus when it comes to the crypto world. Whats your feeling? Is it like youre making Ferraris and people are just parking them in the garage revving the engine for the sake of revving it? Do you see an end to proof of work blockchain in the future that might help resolve that issue? What are your thoughts on the push-pull in that space?

Huang: The reason why Ethereum chose our GPUs is because its the largest network of distributed supercomputers in the world. Its programmable. When Bitcoin first came out, it used our GPU. When Ethereum came out it used our GPU. When other cryptocurrencies came out in the beginning, they established their credibility and their viability and integrity with proof of work using algorithms that run on our GPUs. Its ideal. Its the most energy efficient method, the most performant method, the fastest method, and has the benefit of very large distributed networks. Thats the origins of it.

Am I excited about proof of stake? The answers yes. I believe that the demand for Ethereum has reached such a high level that it would be nice for either somebody to come up with an ASIC that does it, or for there to be another method. Ethereum has established itself. It has the opportunity now to implement a second generation that carries on from the platform approach and all of the services that are built on top of it. Its legitimate. Its established. Theres a lot of credibility. It works well. A lot of people depend on it for DeFi and other things. This is a great time for proof of stake to come.

Now, as we go toward that transition, its now established that Ethereum is going to be quite valuable. Theres a future where the processing of these transactions can be a lot faster, and because there are so many people built on top of it now, Ethereum is going to be valuable. In the meantime there will be a lot of coins mined. Thats why we created this new product called CMP. CMP is right here. It looks like this. This is what a CMP looks like. It has no display connectors, as you can probably see.

The CMP is something we learned from the last generation. What we learned is that, first of all CMP does not yield to GeForce. Its not a GeForce put into a different box. It does not yield to our datacenter. It does not yield to our workstations. It doesnt yield to any of our product lines. It has enough functionality that you can use it for crypto mining.

The $150 million we sold last quarter and the $400 million were projecting to sell this quarter essentially increased supply of our company by half a billion dollars. They were supply that we otherwise couldnt use, and we diverted good yielding supply to GeForce gamers, to workstations and such. The first thing is that CMP effectively increases our supply. CMP also has the after benefit of not being able to be resold secondhand to GeForce customers because it doesnt play games. These things we learned from the last cycle, and hopefully we can take some pressure off of the GeForce gaming side, getting more GeForce supply to gamers.

Above: Perlmutter, the largest NVIDIA A100-powered system in the world.

Image Credit: Nvidia

Question: Theres a shortage problem in the semiconductor market as a whole. The price of GPU products is getting higher. What do you think it will take to stabilize that price?

Huang: Our situation is very different than other peoples situations, as you can imagine. Nvidia doesnt make commodity components. Were not in the DRAM business or the flash business or the CPU business. Our products are not commodity-oriented. Its very specific, for specific applications. In the case of GeForce, for example, we havent raised our price. Our price is basically the same. We have an MSRP. The channel end market prices are higher because demand is so strong.

Our strategy is to alleviate, to reduce the high demand that is caused by crypto mining, and create a special product, the CMP, directly for the crypto miners. If the crypto miners can buy, directly from us, a large volume of GPUs, and they dont yield to GeForce, so they cannot be used for GeForce, but they can be used for crypto mining, it will discourage them from buying from the open market.

The second reason is we introduced new GeForce configurations that reduce the hash rate for crypto mining. We reduced the performance of our GPU on purpose so that if you would like to buy a GPU for gaming, you can. If youd like to buy a GPU for crypto mining, either you can buy the CMP version, or if you really would like to use the GeForce to do it, unfortunately the performance will be reduced. This allows us to save our GPUs for the gamers, and hopefully, as a result, the pricing will slowly come down.

In terms of supply, its the case that the worlds technology industry has reshaped itself. As you know, cloud computing is growing very fast. In the cloud, the datacenters are so big. The chips can be very powerful. Thats why die size, chip size continues to grow. The amount of leading-edge process it consumes is growing. Also, smartphones are using state of the art technology. The leading-edge process consumption used to see some distribution, but now the distribution is heavily skewed toward the leading edge. Technology is moving faster and faster.

The shape of the semiconductor industry changed because of these dynamics. In our case, we have demand that exceeds our supply. Thats for sure. However, as you saw from our last quarters performance, we have enough supply to grow significantly year over year. We have enough supply to grow in Q2 as we guided. We have enough supply to grow in the second half. However, I do wish we had more supply. We have enough supply to grow and grow very nicely. Were very thankful for all of our supply chain and our partners supporting us. But the world is going to be reshaped because of cloud computing, because of the way that computing is going.

Question: When do you think the ongoing chip shortage problem could be solved?

Huang: It just depends on degree and for whom. As you know, we grew tremendously year over year. We announced a great quarter last year. Record quarter for GeForce, for workstations, for datacenters. Although demand was even higher than that, we had enough supply to grow quite nicely year over year. Well grow in Q2. Well grow in the second half. We have supply to do that.

However, there are several dynamics that I think are foundational to our growth. RTX has reset computer graphics. Everyone who has a GTX is looking to upgrade to RTX. RTX is going to reset workstation graphics. There are 45 million designers and creators in the world, and growing. They used to use GTX, but now obviously everyone wants to move to RTX so they can do raytracing in real time. We have this pent-up demand because we reset and reinvented computer graphics. Thats going to drive our demand for some time. It will be several years of pent-up demand that needs to re-upgrade.

In the datacenter its because of AI, because of accelerated computing. You need it for AI and deep learning. We now add to it what I believe will be the long term biggest AI market, which is enterprise industries. Health care is going to be large. Manufacturing, transportation. These are the largest industries in the world. Even agriculture. Retail. Warehouses and logistics. These are giant industries, and they will all be based on AI to achieve productivity and capabilities for their customers.

Now we have that new platform that we just announced at Computex. We have many years of very exciting growth ahead of us. Well just keep working with our supply chain to inform them about the changing world of IT, so that they can be better prepared for the demand thats coming in the future. But I believe that the areas that were in, the markets that were in, because we have very specific reasons, will have rich demand for some time to come.

Above: AI algorithms were developed on Nvidia DGX servers at a U.S. Postal Service Engineering facility.

Image Credit: Nvidia

Question: I see that AMD just announced bringing their RDNA 2 to Arm-based SOCs, collaborating with Samsung to bring raytracing and VR features to Android-based devices. Will there be some further plan from Nvidia to bring RTX technology to consumer devices with Arm-based CPUs?

Huang: Maybe. You know that we build lots of Arm SOCs. We build Arm SOCs for robotics, for the Nintendo Switch, for our self-driving cars. Were very good at building Arm SOCs. The Arm consumer market, I believe, especially for PCs and raytracing games raytracing games are quite large, to be honest. The data set is quite large. There will be a time for it. When the time is right we might consider it. But in the meantime we use our SOCs for autonomous vehicles, autonomous machines, robots, and for Android devices we bring the best games using GeForce Now.

As you know, GeForce Now has more than 10 million gamers on it now. Its in 70 countries. Were about to bring it to the southern hemisphere. Im excited about that. It has 1,000 games, 300 publishers, and it streams in Taiwan. I hope youre using it in Taiwan. Thats how wed like to reach Android devices, Chrome devices, iOS devices, MacOS devices, Linux devices, all kinds of devices, whether its on TV or a mobile device. For us, right now, thats the best strategy.

Above: Jensen Huang of Nvidia holds the worlds largest graphics card.

Image Credit: Nvidia

Question: I wanted to ask you about die size. Obviously with Moores Law, it seems we have the choice of using Moores Law to either shrink the die size or pack more transistors in. In the next few generations, the next three years or so, do you see die sizes shrinking, or do you think theyll stay stable, or even rise again?

Huang: Since the beginning of time, transistor time, die sizes have grown and grown. Theres no question die sizes are increasing. Because technology cycles are increasing in pace, new products are being introduced every year. Theres no time to cost reduce into smaller die sizes. If you look at the trend, its unquestionably to the upper right. If you look at the application space that we see, talking very specifically about us, if you look at our die sizes, there are always reticle limits now. The reticle limits are pretty spectacular. We cant fit another transistor. Thats why we have to use multi-chip packing, of course. We created NVLink to put a bunch of them together. Theres all kinds of strategies to increase the effective die size.

One of the important things is that cloud datacenters so much of the computing experience you have on your phone is because of computers in the cloud. The cloud is a much bigger place. The datacenters are larger. The electricity is more abundant. The cooling system is better. The die size can be very large. Die size is going to continue to grow, even as transistors continue to shrink.

Question: Its expensive to spin up fabs, but in light of the prolonged silicon crunch, is that on the horizon for Nvidia to consider, spinning up a fab for yourself?

Huang: No. Boy, thats the shortest answer Ive had all night. Its the only answer I know, completely. The reason for that, you know theres a difference between a kitchen and a restaurant. Theres a difference between a fab and a foundry. I can spin up a fab, no doubt, just like I can spin up a kitchen, but it wont be a good restaurant. You can spin up a fab, but it wont be a good foundry.

A foundry is a service-oriented business that combines service, agility, technology, capacity, courage, intuition about the future. Its a lot of stuff. The business is not easy. What TSMC does for a living is not easy. Its not going to get any easier, and its not getting easier. Its getting harder. There are so many people who are so good at what they do. Theres no reason for us to go repeating that. We should encourage them to develop the necessary capacity for our platforms benefit.

Meanwhile, they now realize that the leading-edge consumption, leading-edge wafer consumption, the shape has changed because of the way the computing industry is evolving. They see the opportunity in front of them. Theyre racing as fast as they can to increase capacity. I dont think theres anything I can do, that a fabless semiconductor company can do, that can possibly catch up to any of them. So the answer is no.

Above: Nvidias Clara AI for COVID-19 diagnosis from CT scans.

Image Credit: Nvidia

Link:

Nvidia CEO Jensen Huang weighs in on the metaverse, blockchain, and chip shortage - VentureBeat

Maiden Government Blockchain Association Ireland Event to Focus on Blockchain, Identity – Crowdfund Insider

The Government Blockchain Association (GBA) has scheduled its first event in Ireland for 2 p.m. local time (8 a.m. eastern) on June 24. The topics of blockchain and identity will be discussed on Zoom.

The GBA is an international nonprofit association focused on promoting blockchain technology to government while being agnostic to specific solutions. Based in Fairfax, Va, the GBA is open to government employees, private sector professionals and corporations. Fees for government employees are waived. Their goal is to create links between technologists, public policymakers, application specialists, and others interested in digital currencies.

Host Simon Cocking said blockchain technology can propel identity security.

Blockchain technology can help to protect sensitive information. With the power of blockchain-based identity we can transform how our data is used across many industries: finance, banking, travel and healthcare are just a few industries that can use this breakthrough technology. It can help to map your physical identity to your digital footprint, allowing for reduced checks for proof of identification and enabling easier management of records and certificates.

Cocking will be joined by Rob Leslie, founder and CEO of Sedicii, developers of a global identity network; Shiv Aggarwal, founder and CEO of decentralized identity management providers EarthId; AdamBouktila, founder and CEO of digital marketplace DMerch.io and lecturer Paula Marie Kilgarriff, whose interests focus on global retail innovation and emerging technologies.

Digital Identity has the power to fundamentally change peoples lives for the better but it is not without risks, Leslie said. What is at stake is your privacy, your financial security and ultimately who you are as person. Are we ready for it?

GBA Ireland is led by Jillian Godsil and Lisa Gibbons

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Maiden Government Blockchain Association Ireland Event to Focus on Blockchain, Identity - Crowdfund Insider

‘Blockchain technology has the potential to have a greater impact on our lives than the internet’ – ArabianBusiness

What are some common misconceptions you see around the blockchain?

One of the biggest problems that I see currently is that everybodys focused on cryptocurrencies rather than the blockchain itself. They also tend to look at it from a more speculative angle to get fast gains. There are a lot of good projects and a lot of good cryptocurrencies, but there are a lot of bad ones and a lot that its not advisable for people to invest in long term.

That said, I do think that blockchain technology has the potential to have a greater impact on our lives than the internet has.

What is Velas doing in this area?

We have our own proprietary blockchain, which is code based off Solana. We have the fastest blockchain in the world because we offload most of the capacity on to the hardware itself, so were able to reach unprecedented speeds in the blockchain of up to 70,000 transactions per second when Ethereum only does 40,000 and Bitcoin only does 4,000.

On top of that, weve built Ethereum virtual machine compatibility into the Velas blockchain, which means all the applications that were built on Ethereum can now migrate seamlessly on to Velas, and can benefit from our very fast speeds and very cheap transaction fees.

Were essentially building a whole ecosystem. We provide a big platform for a number of decentralised applications (DAPS) to be built on top of us.

What industries do you feel are ripe for blockchain disruption?

As I said, the blockchain sector will disrupt a whole lot of industries, especially telecommunications, energy transfusion, transportation, logistics and government services. What the blockchain is meant to do is eliminate the middle man, and facilitate end point to end point transactions or data communication. In all these sectors, I think the blockchain will be very relevant and will increase efficiency.

What are you doing with NFTs?

We have NFT platforms from the region and from outside that are starting to build on top of us. Were giving them full support on the integration, sharing our community, our knowledge and our developers experience. Here in the region, my partner did an event, painting his car at the Dubai

Opera with a famous Saudi artist. Hes going to do a NFT through a local auction house, with half of the proceeds going to charities around the world, specifically Amazonian indigenous communities.

What are your thoughts on Bitcoin as an asset?

For me, Bitcoin is the equivalent of digital gold. Its a transfer of value, not so much a payment system. Because of its architecture, the Bitcoin blockchain is heavy and slow but it is a very good store of value because there is only a finite amount of Bitcoin that can ever be produced.

The cryptocurrency market has always been volatile. However, as its getting more adoption, going more mainstream with bigger financial institutions coming on board, there will be less and less fluctuation. Right now, there is still a lot to do with regulation. Also, we had the infamous Elon Musk tweets that had some impact on the market. That said, the big crypto whales have accumulated more than $5.5 billion worth when the price dipped, so that should tell you a little bit about where the market should be going next.

When did you first get involved with the blockchain?

I was first introduced to the space in 2016. Once you understand what blockchain and cryptocurrency are, its hard to stop digging and looking more and more into it. My first professional experience would be that we created in 2017 with our wealth management company the first crypto international security identification number (ISIN) one of the first Bitcoin products that could be bought by institutions, because thats where I thought that was going.

But 2017 was the year of initial coin offerings (ICOs) and then in 2018 we entered a bear market. Right now youre seeing more and more of these types of products coming out. The market has only just matured for financial instruments with cryptocurrencies.

Weve done a bunch of other things in the space partnered with numerous companies, ran very large events during the World Economic Forum in Davos, and have ended up being the co-founder of what is now a fourth-generation blockchain company.

What is the importance of scalability in the blockchain space?

This is really important in the space, because as second-generation blockchain, Ethereum has shown us that smart contracts and giving a platform and toolset where communities can build applications is great and fundamentally important. But Ethereum cannot scale to the point of having billions of users the cost of transactions is too high and its just not scalable to that point.

For us, scalability is very important in order to have real-life real cases of using the blockchain in the real world. I think scalability in Velas really can provide that to big industries and all types of different segments of the economy, because transactions have to be cheap and they have to be fast.

Whats your advice to people who missed the first Bitcoin train but want to board the next one?

Always do your own research. Dont be afraid to do the research the informations out there on social media and YouTube. Theres a lot you can learn, and most people in this industry are self-taught.

Dont look at the noise and hype. How we look at projects is by looking at their team, their vision and their core competencies. Thats how we invest in or try to partner with projects that are looking long term and solving some concrete issues.

Just be careful out there and dont invest what you arent afraid of losing.

Brand View allows our business partners to share content with Arabian Business readers.The content is supplied by Arabian Business Brand View Partners.

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'Blockchain technology has the potential to have a greater impact on our lives than the internet' - ArabianBusiness

Observer effect (physics) – Wikipedia

In physics, the observer effect is the disturbance of an observed system by the act of observation.[1] [2] This is often the result of instruments that, by necessity, alter the state of what they measure in some manner. A common example is checking the pressure in an automobile tire; this is difficult to do without letting out some of the air, thus changing the pressure. Similarly, it is not possible to see any object without light hitting the object, and causing it to reflect that light. While the effects of observation are often negligible, the object still experiences a change. This effect can be found in many domains of physics, but can usually be reduced to insignificance by using different instruments or observation techniques.

An especially unusual version of the observer effect occurs in quantum mechanics, as best demonstrated by the double-slit experiment. Physicists have found that even passive observation of quantum phenomena (by changing the test apparatus and passively "ruling out" all but one possibility) can actually change the measured result. Despite the "observer" in this experiment being an electronic detectorpossibly due to the assumption that the word "observer" implies a personits results have led to the popular belief that a conscious mind can directly affect reality.[3] The need for the "observer" to be conscious is not supported by scientific research, and has been pointed out as a misconception rooted in a poor understanding of the quantum wave function and the quantum measurement process,[4][5][6] apparently being the generation of information at its most basic level that produces the effect.

An electron is detected upon interaction with a photon; this interaction will inevitably alter the velocity and momentum of that electron. It is possible for other, less direct means of measurement to affect the electron. It is also necessary to distinguish clearly between the measured value of a quantity and the value resulting from the measurement process. In particular, a measurement of momentum is non-repeatable in short intervals of time. A formula (one-dimensional for simplicity) relating involved quantities, due to Niels Bohr (1928) is given by

where

The measured momentum of the electron is then related to vx, whereas its momentum after the measurement is related to vx. This is a best-case scenario.[7]

In electronics, ammeters and voltmeters are usually wired in series or parallel to the circuit, and so by their very presence affect the current or the voltage they are measuring by way of presenting an additional real or complex load to the circuit, thus changing the transfer function and behavior of the circuit itself. Even a more passive device such as a current clamp, which measures the wire current without coming into physical contact with the wire, affects the current through the circuit being measured because the inductance is mutual.

In thermodynamics, a standard mercury-in-glass thermometer must absorb or give up some thermal energy to record a temperature, and therefore changes the temperature of the body which it is measuring.

The theoretical foundation of the concept of measurement in quantum mechanics is a contentious issue deeply connected to the many interpretations of quantum mechanics. A key focus point is that of wave function collapse, for which several popular interpretations assert that measurement causes a discontinuous change into an eigenstate of the operator associated with the quantity that was measured, a change which is not time-reversible.

More explicitly, the superposition principle ( = nann) of quantum physics dictates that for a wave function , a measurement will result in a state of the quantum system of one of the m possible eigenvalues fn , n = 1, 2, ..., m, of the operator F which in the space of the eigenfunctions n , n = 1, 2, ..., m.

Once one has measured the system, one knows its current state; and this prevents it from being in one of its other statesit has apparently decohered from them without prospects of future strong quantum interference.[8][9][10] This means that the type of measurement one performs on the system affects the end-state of the system.

An experimentally studied situation related to this is the quantum Zeno effect, in which a quantum state would decay if left alone, but does not decay because of its continuous observation. The dynamics of a quantum system under continuous observation are described by a quantum stochastic master equation known as the Belavkin equation.[11][12][13] Further studies have shown that even observing the results after the photon is produced leads to collapsing the wave function and loading a back-history as shown by delayed choice quantum eraser.[14]

When discussing the wave function which describes the state of a system in quantum mechanics, one should be cautious of a common misconception that assumes that the wave function amounts to the same thing as the physical object it describes. This flawed concept must then require existence of an external mechanism, such as a measuring instrument, that lies outside the principles governing the time evolution of the wave function , in order to account for the so-called "collapse of the wave function" after a measurement has been performed. But the wave function is not a physical object like, for example, an atom, which has an observable mass, charge and spin, as well as internal degrees of freedom. Instead, is an abstract mathematical function that contains all the statistical information that an observer can obtain from measurements of a given system. In this case, there is no real mystery in that this mathematical form of the wave function must change abruptly after a measurement has been performed.

A consequence of Bell's theorem is that measurement on one of two entangled particles can appear to have a nonlocal effect on the other particle. Additional problems related to decoherence arise when the observer is modeled as a quantum system, as well.

The uncertainty principle has been frequently confused with the observer effect, evidently even by its originator, Werner Heisenberg.[15] The uncertainty principle in its standard form describes how precisely we may measure the position and momentum of a particle at the same time if we increase the precision in measuring one quantity, we are forced to lose precision in measuring the other.[16]An alternative version of the uncertainty principle,[17] more in the spirit of an observer effect,[18] fully accounts for the disturbance the observer has on a system and the error incurred, although this is not how the term "uncertainty principle" is most commonly used in practice.

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Observer effect (physics) - Wikipedia

Quantum Time Exactly What Is Time?

Max Planck is sometimes considered the father of quantum theory

In the first half of the 20th Century, a whole new theory of physics was developed, which has superseded everything we know about classical physics, and even the Theory of Relativity, which is still a classical model at heart. Quantum theory or quantum mechanics is now recognized as the most correct and accurate model of the universe, particularly at sub-atomic scales, although for large objects classical Newtonian and relativistic physics work adequately.

If the concepts and predictions of relativity (see the section on Relativistic Time) are often considered difficult and counter-intuitive, many of the basic tenets and implications of quantum mechanics may appear absolutely bizarre and inconceivable, but they have been repeatedly proven to be true, and it is now one of the most rigorously tested physical models of all time.

One of the implications of quantum mechanics is that certain aspects and properties of the universe are quantized, i.e. they are composed of discrete, indivisible packets or quanta. For instance, the electrons orbiting an atom are found in specific fixed orbits and do not slide nearer or further from the nucleus as their energy levels change, but jump from one discrete quantum state to another. Even light, which we know to be a type of electromagnetic radiation which moves in waves, is also composed of quanta or particles of light called photons, so that light has aspects of both waves AND particles, and sometimes it behaves like a wave and sometimes it behaved like a particle (wave-particle duality).

An obvious question, then, would be: is time divided up into discrete quanta? According to quantum mechanics, the answer appears to be no, and time appears to be in fact smooth and continuous (contrary to common belief, not everything in quantum theory is quantized). Tests have been carried outusing sophisticated timing equipment and pulsating laser beams to observe chemical changes taking place at very small fractions of a second (down to a femtosecond, or 1015 seconds) and at that level timecertainly appears to be smooth and continuous. However,if time actually is quantized, it is likely to be at the level of Planck time (about 10-43 seconds), the smallest possible length of time according to theoretical physics, and probably forever beyond our practical measurement abilities.

It should be noted that our current knowledge of physics remains incomplete, and, according to some theories that look to combine quantum mechanics and gravity into a single theory of everything (often referred to as quantum gravity see below), there is a possibility that time could in fact be quantized. A hypothetical chronon unit for a proposed discrete quantum of time has been proposed, although it is not clear just how long a chronon should be.

One of the main tenets of quantum theory is that the position of a particle is described by a wave function, which provides the probabilities of finding the particle at any number of different places, or superpositions. It is only when the particle is observed, and the wave function collapses, that the particle is definitively located in one particular place or another. So, in quantum theory, unlike in classical physics, there is a difference between what we see and what actually exists. In fact, the very act of observation affects the observed particle.

Another aspect of quantum theory is the uncertainty principle, which says that the values of certain pairs of variables (such as a particles location and its speed or momentum) cannot BOTH be known exactly, so that the more precisely one variable is known, the less precisely the other can be known. This is reflected in the probabilistic approach of quantum mechanics, something very foreign to the deterministic and certain nature of classical physics.

This view of quantum mechanics (developed by two of the originators of quantum theory, Niels Bohr and Werner Heisenberg), is sometimes referred to the Copenhagen interpretation of quantum mechanics. Because the collapse of the wave function cannot be undone, and because all the information associated with the initial possible positions of the particle contained in the wave function is essentially lost as soon as it is observed and collapsed, the process is considered to be time-irreversible, which has implications for the so-called arrow of time, the one way direction of time that we observe in daily life (see the section on The Arrow of Time).

Some quantum physicists (e.g. Don Page and William Wootters) have developed a theory that time is actually an emergent phenomenon resulting from a strange quantum concept known as entanglement, in which different quantum particles effectively share an existence, even though physically separated, so that the quantum state of each particle can only be described relative to the other entangled particles. The theory even claims to have experimental proof recently, from experiments by Ekaterina Moreva which show that observers do not detect any change in quantum particles (i.e. time foes not emerge) until becoming entangled with another particle.

The Copenhagen interpretation of quantum mechanics, mentioned above, is not however the only way of looking at it. Frustrated by the apparent failure of the Copenhagen interpretation to deal with questions like what counts as an observation, and what is the dividing line between the microscopic quantum world and the macroscopic classical world, other alternative viewpoints have been suggested. One of the leading alternatives is the many worlds interpretation, first put forward by Hugh Everett III back in the late 1950s.

According to the many worlds view, there is no difference between a particle or system before and after it has been observed, and no separate way of evolving. In fact, the observer himself is a quantum system, which interacts with other quantum systems, with different possible versions seeing the particle or object in different positions, for example. These different versions exist concurrently in different alternative or parallel universes. Thus, each time quantum systems interact with each other, the wave function does not collapse but actually splits into alternative versions of reality, all of which are equally real.

This view has the advantage of conserving all the information from wave functions so that each individual universe is completely deterministic, and the wave function can be evolved forwards and backwards. Under this interpretation, quantum mechanics is therefore NOT the underlying reason for the arrow of time.

Quantum gravity, or the quantum theory of gravity, refers to various attempts to combine our two best models of the physics of the universe, quantum mechanics and general relativity, into a workable whole. It looks to describe the force of gravity according to the principles of quantum mechanics, and represents an essential step towards the holy grail of physics, a so-called theory of everything. Quantum theory and relativity, while coexisting happily in most respects, appear to be fundamentally incompatible at unapproachable events like the singularities in black holes and the Big Bang itself, and it is believed by many that some synthesis of the two theories is essential in acquiring a real handle on the fundamental nature of time itself.

Many different approaches to the riddle of quantum gravity have been proposed over the years, ranging from string theory and superstring theory to M-theory and brane theory, supergravity, loop quantum gravity, etc. This is the cutting edge of modern physics, and if a breakthrough were to occur it would likely be as revolutionary and paradigm-breaking as relativity was in 1905, and could completely change our understanding of time.

Any theory of quantum gravity has to deal with the inherent incompatibilities of quantum theory and relativity, not the least of which is the so-called problem of time that time is taken to have a different meaning in quantum mechanics and general relativity. This is perhaps best exemplified by the Wheeler-DeWitt equation, devised by John Wheeler and Bruce DeWitt back in the 1970s. Their attempt to unify relativity and quantum mechanics resulted in time essentially disappearing completely from their equations, suggesting that time does not exist at all and that, at its most fundamental level, the universe is timeless. In response to the Wheeler-DeWitt equation, some have concluded that time is a kind of fictitious variable in physics, and that we are perhaps confusing the measurement of different physical variables with the actual existence of something we call time.

While looking to connect quantum field theory with statistical mechanics, theoretical physicist Stephen Hawking introduced a concept he called imaginary time. Although rather difficult to visualize, imaginary time is not imaginary in the sense of being unreal or made-up. Rather, it bears a similar relationship to normal physical time as the imaginary number scale does to the real numbers in the complex plane, and can perhaps best be portrayed as an axis running perpendicular to that of regular time. It provides a way of looking at the time dimension as if it were a dimension of space, so that it is possible to move forwards and backwards along it, justas one can move right and left or up and down in space.

Despite its rather abstract and counter-intuitive nature, the usefulness of imaginary time arises in its ability to help mathematically to smooth out gravitational singularities in models of the universe. Normally, singularities (like those at the centre of black holes, or the Big Bang itself) pose a problem for physicists, because they are areas where the known physical laws just do not apply. When visualized in imaginary time, however, the singularity is removed and the Big Bang functions like any other point in space-time.

Exactly what such a concept might represent in the real world, though,is unknown, and currently it remainslittle more than a potentially useful theoretical construct.

>> Time and the Big Bang

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Quantum Time Exactly What Is Time?

Breaking Heisenberg: Evading the Uncertainty Principle in …

Schematic of the entangled drumheads. Credit: Aalto University

New technique gets around 100-year-old rule of quantum physics for the first time.

The uncertainty principle, first introduced by Werner Heisenberg in the late 1920s, is a fundamental concept of quantum mechanics. In the quantum world, particles like the electrons that power all electrical products can also behave like waves. As a result, particles cannot have a well-defined position and momentum simultaneously. For instance, measuring the momentum of a particle leads to a disturbance of position, and therefore the position cannot be precisely defined.

In recent research, published in Science, a team led by Prof. Mika Sillanp at Aalto University in Finland has shown that there is a way to get around the uncertainty principle. The team included Dr. Matt Woolley from the University of New South Wales in Australia, who developed the theoretical model for the experiment.

Instead of elementary particles, the team carried out the experiments using much larger objects: two vibrating drumheads one-fifth of the width of a human hair. The drumheads were carefully coerced into behaving quantum mechanically.

In our work, the drumheads exhibit a collective quantum motion. The drums vibrate in an opposite phase to each other, such that when one of them is in an end position of the vibration cycle, the other is in the opposite position at the same time. In this situation, the quantum uncertainty of the drums motion is canceled if the two drums are treated as one quantum-mechanical entity, explains the lead author of the study, Dr. Laure Mercier de Lepinay.

This means that the researchers were able to simultaneously measure the position and the momentum of the two drumheads which should not be possible according to the Heisenberg uncertainty principle. Breaking the rule allows them to be able to characterize extremely weak forces driving the drumheads.

One of the drums responds to all the forces of the other drum in the opposing way, kind of with a negative mass, Sillanp says.

Furthermore, the researchers also exploited this result to provide the most solid evidence to date that such large objects can exhibit what is known as quantum entanglement. Entangled objects cannot be described independently of each other, even though they may have an arbitrarily large spatial separation. Entanglement allows pairs of objects to behave in ways that contradict classical physics, and is the key resource behind emerging quantum technologies. A quantum computer can, for example, carry out the types of calculations needed to invent new medicines much faster than any supercomputer ever could.

In macroscopic objects, quantum effects like entanglement are very fragile, and are destroyed easily by any disturbances from their surrounding environment. Therefore, the experiments were carried out at a very low temperature, only a hundredth a degree above absolute zero at -273 degrees.

In the future, the research group will use these ideas in laboratory tests aiming at probing the interplay of quantum mechanics and gravity. The vibrating drumheads may also serve as interfaces for connecting nodes of large-scale, distributed quantum networks.

Reference: Quantum mechanicsfree subsystem with mechanical oscillators by Laure Mercier de Lpinay, Caspar F. Ockeloen-Korppi, Matthew J. Woolley and Mika A. Sillanp, 7 May 2021, Science.DOI: 10.1126/science.abf5389

Sillanps group is part of the national Centre of Excellence, Quantum Technology Finland (QTF). The research was carried out using OtaNano, a national open access research infrastructure providing state-of-the-art working environment for competitive research in nanoscience and -technology, and in quantum technologies. OtaNano is hosted and operated by Aalto University and VTT.

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Breaking Heisenberg: Evading the Uncertainty Principle in ...