Electrical and Behavioral Signals in OCD Could Guide Adaptive Therapy – Genetic Engineering & Biotechnology News

In an effort to improve treatment for obsessive compulsive disorder (OCD), researchers headed by teams at Brown University, and Baylor College of Medicine, have for the first time recorded electrical signals in the human brain that are associated with ebbs and flows in OCD symptoms, over an extended period, while individuals went about daily living in their homes. The research could be an important step in making an emerging therapy called deep brain stimulation (DBS) responsive to everyday changes in OCD symptoms.

In addition to advancing DBS therapy for cases of severe and treatment resistant OCD, this study has the potential for improving our understanding of the underlying neurocircuitry of the disorder, said Wayne Goodman, PhD, at Baylor College of Medicine. This deepened understanding may allow us to identify new anatomic targets for treatment that may be amenable to novel interventions that are less invasive than DBS. Goodman is co-author of the researchers published paper in Nature Medicine, which is titled, Long-term ecological assessment of intracranial electrophysiology synchronized to behavioural markers in obsessive-compulsive disorder.

OCD causes recurring unwanted thoughts and repetitive behaviors, and is a leading cause of disability. The condition, which is often debilitating, may affect perhaps 2-3% of the worlds population, the authors noted. Up to 20-40% of cases dont respond to traditional drug or behavioral treatments. Approximately 10% of individuals fail to achieve benefit from any intervention.

Deep brain stimulation, a technique that involves delivering mild electrical pulses via small electrodes precisely placed in the brain, can be effective in treating more than 50% of patients for whom other therapies failed. Over half of patients with treatment-resistant OCD are responders to DBS targeted to the ventral capsule/ventral striatum (VC/VS) region, the researchers further noted. To date, however, the number of patients who have received DBS for OCD is still in the hundreds.

One limitation of DBS is that it is unable to adjust to moment-to-moment changes in OCD symptoms, which are impacted by the physical and social environment. But adaptive DBS which can adjust the intensity of stimulation in response to real-time signals recorded in the braincould be more effective than traditional DBS and reduce unwanted side effects.

OCD is a disorder in which symptom severity is highly variable over time and can be elicited by triggers in the environment, said David Borton, PhD, an associate professor of biomedical engineering at Brown University, a biomedical engineer at the US Department of Veterans Affairs Center for Neurorestoration and Neurotechnology and a senior author of the new research. A DBS system that can adjust stimulation intensity in response to symptoms may provide more relief and fewer side effects for patients. But in order to enable that technology, we must first identify the biomarkers in the brain associated with OCD symptoms, and that is what we are working to do in this study. As the authors noted, An electrophysiological biomarker of symptom state would enable aDBS for OCD and other psychiatric disorders, which may provide a better approach for treating fluctuations in symptom intensity.

The research, led by Nicole Provenza, a recent Brown biomedical engineering PhD graduate from Bortons laboratory, was a collaboration between Bortons research group, affiliated with Browns Carney Institute for Brain Science and School of Engineering; the research groups of Wayne Goodman PhD, and Sameer Sheth MD, PhD, at Baylor College of Medicine; and Jeff Cohn, PhD, from the University of Pittsburghs Department of Psychology and Intelligent Systems Program and Carnegie Mellon University.

For their study, Goodmans team recruited five participants with severe OCD who were eligible for DBS treatment. Sheth, lead neurosurgeon, implanted in each participant an investigational DBS device from Medtronic, which is capable of both delivering stimulation and recording native electrical brain signals. Using the sensing capabilities of the hardware, the team gathered brain-signal data from participants in both clinical settings and at home as they went about daily activities. The DBS implants used in our study allow for real-time frequency-domain analysis of electrophysiological activity recorded simultaneously during stimulation delivery from the implanted electrodes, they wrote.

Along with the brain signal data, the team also collected a suite of behavioral biomarkers. In the clinical setting, these included facial expression (automatic facial affect recognition; AFAR) and body movement. Using computer vision and machine learning, they discovered that the behavioral features were associated with changes in internal brain states. At the participants homes, the team measured self-reports of OCD symptom intensity as well as biometric dataheart rate and general activity levelsrecorded by a smart watch and paired smartphone application, provided by Rune Labs. All of those behavioral measures were then time-synched to the brain-sensing data, enabling the researchers to look for correlations between the two.

Here, we acquired electrophysiological data with behavioral readouts over both short and long timescales, the team commented. In the clinic, we examined changes in affect (AFAR) during DBS parameter changes over short timescales (seconds to minutes). At home during participant-controlled recordings, we captured behavioral changes (self-reported OCD symptoms) over longer timescales (days to weeks to months) in natural settings, collected continuous data during natural and planned exposures, and developed methods to synchronize behavioral metrics to intracranial electrophysiology.

This is the first time brain signals from participants with neuropsychiatric illness have been recorded chronically at home alongside relevant behavioral measures, Provenza said. Using these brain signals, we may be able to differentiate between when someone is experiencing OCD symptoms, and when they are not, and this technique made it possible to record this diversity of behavior and brain activity.

Provenzas analysis of the data showed that the strategy did pick out brain-signal patterns potentially linked to OCD symptom fluctuation. While more work needs to be done across a larger cohort, this initial study shows that this technique is a promising way forward in confirming candidate biomarkers of OCD. we demonstrated the utility of at-home data collection for biomarker identification by observing correlations between spectral power and self-reported OCD symptom intensity.

We were able to collect a far richer dataset than has been collected before, and we found some tantalizing trends that wed like to explore in a larger cohort of patients, Borton said. Now we know that we have the toolset to nail down control signals that could be used to adjust stimulation level according to peoples symptoms.

Once those biomarkers are positively identified, they could then be used in an adaptive DBS system. Currently, DBS systems employ a constant level of stimulation, which can be adjusted by a clinician at clinical visits. Adaptive DBS systems, in contrast, would stimulate and record brain activity and behavior continuously without the need to attend clinic. When the system detects signals associated with an increase in symptom severity, it could ramp up stimulation to potentially provide additional relief. Likewise, stimulation could be toned down when symptoms abate. Such a system could potentially improve DBS therapy while reducing side effects.

Work on this line of research is ongoing. Because OCD is a complex disorder than manifests itself in highly variable ways across patients, the team hopes to expand the number of participants to capture more of that variability. They seek to identify a fuller set of OCD biomarkers that could be used to guide adaptive DBS systems. Once those biomarkers are in place, the team hopes to work with device makers to implement their DBS devices.

Our goal is to understand what those brain recordings are telling us and to train the device to recognize certain patterns associated with specific symptoms, Sheth said. The better we understand the neural signatures of health and disease, the greater our chances of using DBS to successfully treat challenging brain disorders like OCD. As the authors concluded, This work demonstrates the feasibility and utility of capturing chronic intracranial electrophysiology during daily symptom fluctuations to enable neural biomarker identification, a prerequisite for future development of adaptive DBS for OCD and other psychiatric disorders, the author concluded. The platform presented here lays the groundwork for future transformational studies reliant on ecological neural and behavioral monitoring and assessment of neuropsychiatric illness.

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Electrical and Behavioral Signals in OCD Could Guide Adaptive Therapy - Genetic Engineering & Biotechnology News

Gene Network Changes Associated with Cancer Onset and Progression Identify New Candidates for Targeted Gene Therapy | Research – Research Horizons

Cancer chemotherapy has undergone a paradigm shift in recent years with traditional treatments like broad-spectrum cytotoxic agents being complemented or replaced by drugs that target specific genes believed to drive the onset and progression of the disease.

This more personalized approach to chemotherapy became possible when genomic profiling of individual patient tumors led researchers to identify specific "cancer driver genes" that, when mutated or abnormally expressed, led to the onset and development of cancer.

Different types of cancer like lung cancer versus breast cancer and, to some extent, different patients diagnosed with the same cancer type show variations in the cancer driver genes believed to be responsible for disease onset and progression. For example, the therapeutic drug Herceptin is commonly used to treat breast cancer patients when its target gene, HER-2, is found to be over-expressed, says John F. McDonald, professor in the School of Biological Sciences.

McDonald explains that, currently, the identification of potential targets for gene therapy relies almost exclusively on genomic analyses of tumors that identify cancer driver genes that are significantly over-expressed.

But in their latest study, McDonald and Bioinformatics Ph.D. student Zainab Arshad have found that another important class of genetic changes may be happening in places where scientists dont normally look: the network of gene-gene interactions associated with cancer onset and progression.

Genes and the proteins they encode do not operate in isolation from one another, McDonald says. Rather, they communicate with one another in a highly integrated network of interactions.

What I think is most remarkable about our findings is that the vast majority of changes more than 90% in the network of interactions accompanying cancer are not associated with genes displaying changes in their expression, adds Arshad, co-author of the paper. What this means is that genes playing a central role in bringing about changes in network structure associated with cancer the hub genes may be important new targets for gene therapy that can go undetected by gene expression analyses.

Their research paper Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression is published in the journal iScience.

Mutations, expression and changes in network structure

In the study, Arshad and McDonald worked with samples of brain, thyroid, breast, lung adenocarcinoma, lung squamous cell carcinoma, skin, kidney, ovarian, and acute myeloid leukemia cancers and they noticed differences in cell network structure for each of these cancers as they progressed from early to later stages.

When early-stage cancers develop, and stayed confined to their body tissue of origin, they noted a reduction in network complexity relative to normal pre-cursor cells. Normal, healthy cells are highly differentiated, but as they transition to cancer, [T]hey go through a process of de-differentiation to a more primitive or stem cell-like state. Its known from developmental biology that as cells transition from early embryonic stem cells to highly specialized fully differentiated cells, network complexity increases. What we see in the transition from normal to early-stage cancers is a reversal of this process, McDonald explains.

McDonald says as the cancers progress to advanced stages, when they can spread or metastasize to other parts of the body, [W]e observe re-establishment of high levels of network complexity, but the genes comprising the complex networks associated with advanced cancers are quite different from those comprising the complex networks associated with the precursor normal tissues.

As cancers evolve in function, they are typically associated with changes in DNA structure, and/or with changes in the RNA expression of cancer driver genes. Our results indicate that theres an important third class of changes going on changes in gene interactions and many of these changes are not detectable if all youre looking for are changes in gene expression.

DOI:https://doi.org/10.1016/j.isci.2021.103522

Acknowledgments: This research was supported by the Mark Light Integrated Cancer Research Center Student Fellowship , the Deborah Nash Endowment Fund , and the Ovarian Cancer Institute (Atlanta), where John F. McDonald serves as chief research officer. The results shown here are based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/.

About Georgia Institute of Technology

The Georgia Institute of Technology, or Georgia Tech, is a top 10 public research university developing leaders who advance technology and improve the human condition. The Institute offers business, computing, design, engineering, liberal arts, and sciences degrees. Its nearly 40,000 students representing 50 states and 149 countries, study at the main campus in Atlanta, at campuses in France and China, and through distance and online learning. As a leading technological university, Georgia Tech is an engine of economic development for Georgia, the Southeast, and the nation, conducting more than $1 billion in research annually for government, industry, and society.

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Gene Network Changes Associated with Cancer Onset and Progression Identify New Candidates for Targeted Gene Therapy | Research - Research Horizons

Researchers ‘turn off’ driver of aortic stenosis heart disease | Cornell Chronicle – Cornell Chronicle

Researchers have discovered how to turn off a key driver of aortic stenosis the narrowing of the hearts aortic valve identifying for the first time the biological process behind certain instances of the disease in which heart valves become calcified and damaged.

The research was reported Nov. 5 in Science Advances, and the breakthrough was over a decade in the making for the studys co-author Jonathan Butcher, professor of biomedical engineering.

Since 2009, Butcher has been studying cells essential for embryonic development of the cardiovascular system. Wanting to show what a subset of those cells would do in a disease state, he published a 2012 study finding that a specific type of inflammation can trigger the cells to undergo the same biological process as they do in the development stage.

Developmental biology used to be studied completely separate from adult disease because they were seen as driving two completely different systems, Butcher said. More recently, theres been the idea that molecules that drive tissue formation might also be involved in forming a tissue-level response to an external stimulus like a disease.

In the case of the cells responsible for heart valve development and disease, Butcher wanted to know more about their shared regulatory component.

Butcher was presenting his work at a research consortium in which another researcher, Michel Puceat from Aix-Marseille University, shared research on a natural biological program in adult mouse heart valves known as OCT4, which Butcher recognized as an early development program and was surprised to see in adult subjects.

The researchers agreed to work together, doing molecular gain and loss of function studies to show that OCT4 switches off very early in embryonic development, but can be turned on later in adulthood. What flips the switch is the inflammatory transcription factor NF kappa B the same one Butcher had studied a decade ago but this time, the OCT4 program was operating a different lineage of cells.

We found this nascent ability of the cells to form bone thats suppressed in the embryonic environment, Butcher said, but in the adult disease environment, its now amplifying that nascent desire to become an osteochondral progenitor.

Essentially, inflammation can switch on dormant embryonic programming in adult cells, and the disease environment leads them to behave differently and calcify the heart valve, causing aortic stenosis.

For the last portion of the study, the researchers wanted to see if they could prevent stenosis in mice by genetically deactivating the OCT4 program after its embryonic role was finished. The experiment was successful, and mice with OCT4 deleted in pro-valve tissue resisted the disease despite having the genetic risk factor and a high-fat, inflammation-inducing diet.

The difference was remarkable and it suggests this particular mechanism could be a pretty safe way to treat the disease because you're not going to worry about disrupting a whole bunch of other things, said Butcher, who added that there are several options for exploring a therapy for humans. We might be able to block it with anti-inflammatory drugs that stop the switch operator, or it might be safer to block it by manipulating this transformation component downstream.

Butcher said the research is an example of observing and targeting emergent phenomena by going beyond the traditional method of studying individual cells and molecules as disease drivers, and instead observing the relationships between components.

This particular work to me was something that really engaged the ingenuity of a lot of people, Butcher said. This concept of emergence will be critically important for developing next-level therapy for diseases.

The research was funded by the Leducq Foundation, the National Institutes of Health and the National Science Foundation.

Syl Kacapyr is public relations and content manager for the College of Engineering.

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Researchers 'turn off' driver of aortic stenosis heart disease | Cornell Chronicle - Cornell Chronicle

Fate Therapeutics Showcases Positive Interim Phase 1 Data from FT596 Off-the-shelf, … – The Bakersfield Californian

5 of 6 Patients Achieve Objective Response, including 4 Patients with Complete Response, with Single Dose of FT596 at 900 Million Cells in Combination with Rituximab

13 of 19 Patients Achieve Objective Response with Single Dose of FT596 at 90 Million and 300 Million Cell Dose; 10 of 11 Patients Treated with a Second FT596 Cycle Continue in Ongoing Response, with 3 Patients in Ongoing Complete Response at 6 Months Follow-up; Additional 2 Patients Reach 6 Months in Complete Response

FT596 Treatment Regimens were Well-tolerated; No Dose-limiting Toxicities, and No Adverse Events of Any Grade of ICANS or GVHD, were Observed; Three Low-grade Adverse Events of CRS Resolved without Intensive Care Treatment

Company to Host Virtual Investor Event Tomorrow at 8:00 AM Eastern Time

SAN DIEGO, Dec. 13, 2021 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer, today showcased positive interim Phase 1 data from the Companys FT596 program for patients with relapsed / refractory B-cell lymphoma (BCL) at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition. FT596 is the Companys off-the-shelf, multi-antigen targeted, iPSC-derived natural killer (NK) cell product candidate derived from a clonal master induced pluripotent stem cell (iPSC) line engineered with three anti-tumor functional modalities: a proprietary chimeric antigen receptor (CAR) optimized for NK cell biology that targets B-cell antigen CD19; a novel high-affinity, non-cleavable CD16 (hnCD16) Fc receptor that has been modified to prevent its down-regulation and to enhance its binding to tumor-targeting antibodies; and an IL-15 receptor fusion (IL-15RF) that augments NK cell activity.

The interim dose-escalation clinical data from our FT596 program in relapsed / refractory B-cell lymphoma demonstrate that off-the-shelf, iPSC-derived CAR NK cells can bring substantial therapeutic benefit to heavily pre-treated patients in urgent need of therapy, with high response rates and meaningful duration of responses, said Scott Wolchko, President and Chief Executive Officer of Fate Therapeutics. We are particularly pleased with the therapeutic profile that has emerged with FT596 in combination with rituximab, where over half of the patients treated with a single dose of FT596 at higher dose levels achieved a complete response with a favorable safety profile that is clearly differentiated from CAR T-cell therapy. We look forward to assessing a two-dose treatment schedule for FT596 to further define its potential best-in-class therapeutic profile and ability to reach more patients, including those earlier in care.

The ongoing Phase 1 study in relapsed / refractory BCL is assessing a single dose of FT596 as monotherapy (Monotherapy Arm) and in combination with a single dose of rituximab (375 mg/m2) (Combination Arm) following three days of conditioning chemotherapy (500 mg/m2 of cyclophosphamide and 30 mg/m2 of fludarabine). Certain patients are eligible for re-treatment with a second, single-dose cycle.

The ASH presentation ( Session 704Cellular Immunotherapies: Expanding Targets and Cellular Sources for Immunotherapies, Abstract 823 ) includes clinical data from 25 evaluable patients for safety (n=12 in Monotherapy Arm; n=13 in Combination Arm) in the first, second, and third single-dose cohorts of 30 million, 90 million, and 300 million cells, respectively, of which 24 patients were also evaluable for efficacy (n=12 in Monotherapy Arm; n=12 in Combination Arm), as of the data cutoff date of October 11, 2021. These 25 patients had received a median of four prior lines of therapy and a median of two prior lines containing CD20-targeted therapy. Of the 25 patients, 15 patients (60%) had aggressive B-cell lymphoma, 15 patients (60%) were refractory to most recent prior therapy, and 8 patients (32%) were previously treated with autologous CD19-targeted CAR T-cell therapy. Subsequent to the data cutoff date for the ASH presentation, an additional patient in the third single-dose cohort of the Combination Arm was evaluable for initial anti-tumor response, and seven patients in the fourth single-dose cohort of 900 million cells (n=1 in Monotherapy Arm; n=6 in Combination Arm) were evaluable for safety and initial anti-tumor response.

Single-dose, Single-cycle Response Data

In the second, third, and fourth dose cohorts of the Monotherapy and Combination Arms comprising a total of 26 patients, 18 patients (69%) achieved an objective response, including 12 patients (46%) that achieved a complete response, on Day 29 following a single dose of FT596 (see Table 1). Nine of these 26 patients were previously treated with autologous CD19-targeted CAR T-cell therapy and, of these nine patients, six achieved an objective response (67%) on Day 29 following a single dose of FT596. Notably, in the third and fourth dose cohorts of the Combination Arm comprising a total of 12 patients, nine patients (75%) achieved an objective response, including seven patients (58%) that achieved a complete response, on Day 29 following a single dose of FT596.

Durability of Response Data

The ASH presentation includes durability of response data from 13 responding patients in the second and third single-dose cohorts of 90 million cells and 300 million cells (n=9 in Monotherapy Arm; n=10 in Combination Arm). As of the data cutoff date of October 11, 2021, 10 patients continued in ongoing response, including three patients in ongoing complete response at least six months from initiation of treatment; two patients reached six months in complete response and subsequently had disease progression; and one patient had disease progression prior to six months. Of these 13 responding patients:

Monotherapy Arm (n=7 responding patients). Five patients, all of whom were treated with a second FT596 single-dose cycle with the consent of the U.S. Food and Drug Administration (FDA), continued in ongoing response at a median follow-up of 4.1 months, including one patient in ongoing complete response at 8.1 months; one patient, who was treated with only one FT596 single-dose cycle, reached six months in complete response and subsequently had disease progression at 6.5 months; and one patient, who was treated with only one FT596 single-dose cycle, had disease progression at 1.7 months.Combination Arm (n=6 responding patients). Five patients, all of whom were treated with a second FT596 single-dose cycle with the consent of the FDA, continued in ongoing response at a median follow-up of 4.6 months, including two patients in ongoing complete response at 6.0 and 10.8 months; and one patient, who was treated with a second FT596 single-dose cycle with the consent of the FDA, reached six months in complete response and subsequently had disease progression at 6.7 months.

aCD19 = autologous CD19-targeted CAR T-cell therapy; Aggressive = diffuse large B-cell lymphoma, Grade 3b follicular lymphoma, Richters transformation, and high-grade B-cell lymphoma; CR = complete response; Indolent = splenic diffuse red pulp small B-cell lymphoma, non-Grade 3b follicular lymphoma, Waldenstroms macroglobulinemia, and small lymphocytic lymphoma; M = million; OR = objective response 1 As of data cutoff date of October 11, 2021, unless otherwise noted. Objective response and complete response are based on Cycle 1 Day 29 protocol-defined response assessment per Lugano 2014 criteria. Data subject to source document verification. 2 Cycle 1 Day 29 protocol-defined response assessment completed subsequent to data cutoff date for one patient in the third single-dose cohort of 300 million cells in the Combination Arm and seven patients in the fourth single-dose cohort of 900 million cells (n=1 in Monotherapy Arm; n=6 in Combination Arm).

Safety Data

The FT596 treatment regimens were well tolerated, including in those patients treated with a second, single-dose cycle. No dose-limiting toxicities, and no treatment-emergent adverse events (TEAEs) of any grade of immune effector cell-associated neurotoxicity syndrome (ICANS) or graft-versus-host disease (GvHD) were observed. Three low-grade adverse events (two Grade 1, one Grade 2) of cytokine release syndrome (CRS) were reported, which were of limited duration and resolved without intensive care treatment (see Table 2).

The Company has initiated enrollment of a two-dose treatment schedule in the Combination Arm, with FT596 administered on Day 1 and Day 15 at 900 million cells per dose. Patients with clinical benefit following administration of the first two-dose cycle are eligible for re-treatment with a second two-dose cycle. Additionally, patients with clinical response are eligible for re-treatment following disease progression.

CRS = Cytokine Release Syndrome; GvHD = Graft vs. Host Disease; ICANS = Immune Cell-Associated Neurotoxicity Syndrome; TEAE = Treatment-Emergent Adverse Event; SAE = Severe Adverse Events a Grade 2 CRS

Investor Event Webcast

The Company will host a live audio webcast on Tuesday, December 14, 2021 at 8:00 a.m. ET to highlight interim Phase 1 clinical data from the Companys FT516 and FT596 programs for the treatment of relapsed / refractory B-cell lymphoma. The live webcast can be accessed under "Events & Presentations" in the Investors section of the Company's website at http://www.fatetherapeutics.com. The archived webcast will be available on the Company's website beginning approximately two hours after the event.

About Fate Therapeutics iPSC Product Platform The Companys proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that are designed to be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Companys first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Companys platform is uniquely designed to overcome numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics iPSC product platform is supported by an intellectual property portfolio of over 350 issued patents and 150 pending patent applications.

About FT596 FT596 is an investigational, universal, off-the-shelf natural killer (NK) cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line engineered with three anti-tumor functional modalities: a proprietary chimeric antigen receptor (CAR) optimized for NK cell biology that targets B-cell antigen CD19; a novel high-affinity 158V, non-cleavable CD16 (hnCD16) Fc receptor, which has been modified to prevent its down-regulation and to enhance its binding to tumor-targeting antibodies; and an IL-15 receptor fusion (IL-15RF) that augments NK cell activity. In preclinical studies of FT596, the Company has demonstrated that dual activation of the CAR19 and hnCD16 targeting receptors enhances cytotoxic activity, indicating that multi-antigen engagement may elicit a deeper and more durable response. Additionally, in a humanized mouse model of lymphoma, FT596 in combination with the anti-CD20 monoclonal antibody rituximab showed enhanced killing of tumor cells in vivo as compared to rituximab alone. FT596 is being investigated in a multi-center Phase 1 clinical trial for the treatment of relapsed / refractory B-cell lymphoma as a monotherapy and in combination with rituximab, and for the treatment of relapsed / refractory chronic lymphocytic leukemia (CLL) as a monotherapy and in combination with obinutuzumab (NCT04245722).

About Fate Therapeutics, Inc. Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Companys immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit http://www.fatetherapeutics.com.

Forward-Looking Statements This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the safety and therapeutic potential of the Companys iPSC-derived NK cell product candidates, including FT596, its ongoing and planned clinical studies, and the expected clinical development plans for FT596. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that results observed in studies of its product candidates, including preclinical studies and clinical trials of any of its product candidates, will not be observed in ongoing or future studies involving these product candidates, the risk that the Company may cease or delay clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials, the amount and type of data to be generated, or otherwise to support regulatory approval, difficulties or delays in subject enrollment and continuation in current and planned clinical trials, difficulties in manufacturing or supplying the Companys product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), and the risk that its product candidates may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Companys actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Companys periodic filings with the Securities and Exchange Commission, including but not limited to the Companys most recently filed periodic report, and from time to time in the Companys press releases and other investor communications.Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise.

Contact: Christina Tartaglia Stern Investor Relations, Inc. 212.362.1200 christina@sternir.com

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Fate Therapeutics Showcases Positive Interim Phase 1 Data from FT596 Off-the-shelf, ... - The Bakersfield Californian

ACT Party’s boycott of RNZ’s Morning Report caused by host …

The term 'eugenics' refers to the selection of desired heritable characteristics in order to improve future generations, and is often associated with Nazi Germany.

Morton's complaint against RNZ over the comment was not upheld. The BSA in April 2021 found no breaches of its guidelines for Good Taste and Decency, Balance, Accuracy or Fairness, and said the ACT Party was "treated fairly in the context of the debate".

But Morton told Newshub on Thursday the comment was the final straw for the party, and since then, no ACT MPs have appeared in live interviews for the show.

Newshub has reached out to RNZ for comment.

The boycott first came to light on Thursday morning, after The Spinoff published an interview with Seymour in which he described Morning Report as rude, selective and dishonest about what they wanted to talk about.

"After the umpteenth time that I went on their show out of a feeling of public duty and was belittled and abused with all their snarkiness, I just thought, 'I don't need this,'" he said.

But he told The Spinoff that the "really toxic and comically Lilliputian culture of Morning Report" was different from the rest of RNZ, and ACT MPs would happily appear on the station's other shows.

Morton told Newshub ACT MPs still also appear in pre-recorded interviews that are played as part of Morning Report's news bulletins.

While Seymour was happy for his party to ditch Morning Report, he decried Jacinda Ardern's decision to do much the same thing earlier this year, when she pulled out of her weekly slot on Newstalk ZB's Mike Hosking Breakfast show.

He said in March the Prime Minister was avoiding answering questions by "de-platforming" herself from the weekly slot.

"Jacinda Ardern will ultimately regret this escalating arrogance, the latest example being cancelling her weekly discussion with Newstalk ZB's Mike Hosking," Seymour said.

"It joins a long list of increasingly hubristic moves from the Prime Minister and her Government."

Ardern said the decision was made so she could branch out more to other media outlets, but broadcaster Hosking said in March that Ardern was "running for the hills" and was "over being held to account".

He said he didn't want Ardern back on his show after she cancelled the slot, which had been observed by New Zealand Prime Ministers for more than 30 years.

Often critical of the Government, Hosking said late last year people "misunderstand" his relationship with Ardern and despite often fiery interviews, he actually "likes her a lot".

"It's our work," Hosking said in December. "It's what we do. There's nothing personal in it."

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ACT Party's boycott of RNZ's Morning Report caused by host ...

Letter: Pay attention to facts – The Columbian

I am glad readers are somewhat perusing my letters. Lets pay attention to facts and details.

A recent letter substituted progressives to Democrats (historically correct) with a bold assertion that Democrats nor the left support eugenics, abortion or cultural cleansing. Those were progressive pursuits. But, when reading the Democratic Party platform, one will read these words: that every woman should be able to access high-quality reproductive health care services, including safe and legal abortion. Again, corroborate what you know or believe.

This verification unequivocally refutes the claim that the Democrats and the left do not support abortions specifically. Do readers follow voting records of politicians or actions of the Department of Justice that the current administration advocate? Should the Democratic Party platform be denounced?

Another rebuttal is necessary. The major increase in crime during the Trump administration occurred largely in states and cities that are Democratic bastions wholly under their jurisdictions. President Trump honored the Ninth and 10th amendments. Crime and civil violence are escalating under this current administration. Can these points be refuted? No. Be cognizant of what is going on in Portland, Seattle, San Francisco, and more.

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Letter: Pay attention to facts - The Columbian

Bioethicists Okay Human Extinction to Eliminate Suffering – National Review

(solarseven/iStock/Getty Images)

These days, anti-humanism is as thick as molasses among the intelligentsia. That includes an ongoing conversation in bioethics whether all things considered human extinction would be a fine thing because of the suffering that never coming into existence would avoid.

Example: A few months ago, Oxford professor Roger Crisp opined that we might not want to stop a huge asteroid from hitting the Earth. From Would extinction be so bad?:

Consider the huge amount of suffering that continuing existence will bring with it, not only for humans, and perhaps even for post-humans, but also for sentient non-humans, who vastly outnumber us and almost certainly would continue to do so. As far as humans alone are concerned, Hilary Greaves and Will MacAskill at the University of Oxfords Global Priorities Institute estimate that there could beone quadrillion(1015) people to come an estimate they describe as conservative.

These numbers, and the scale of suffering to be put into the balance alongside the good elements in individuals lives, are difficult to fathom and so large that its not obvious that you should deflect the asteroid. In fact, there seem to be some reasons to think you shouldnt.

Perhaps one reason we think extinction would be so bad is that we have failed to recognise just how awful extreme agony is. Nevertheless, we have enough evidence, and imaginative capacity, to say that it is not unreasonable to see the pain of an hour of torture as something that can never be counterbalanced by any amount of positive value. And if this view is correct, then it suggests that the best outcome would be the immediate extinction that follows from allowing an asteroid to hit our planet.

Crisp equivocates a bit at the end, writing, I am not claiming that extinction wouldbe good;only that, since itmight be, we should devote a lot more attention to thinking about the value of extinction than we have to date. Good grief. Is the issue really debatable?

Not to be outdone, writing in response to Crisp in the Journal of Medical Ethics Blog, University of Calgary professor Walter Glannon shrugs his big brain at the prospect of us being gone. From A world without us:

We cannot predict the sort of lives future people would have because we do not know the sort of world they would inhabit. But the circumstances described above make it difficult to be optimistic. Regardless of the hypothetical value or disvalue of these lives, possible people are not deprived of anything if they do not come into existence.

We have an obligation to collectively act to prevent or reduce the suffering that present and future humans will actually experience. This depends on controlling natural habitats, deforestation, carbon emissions and other processes. Future actual people have the same rights and interests in avoiding suffering as present actual people. The extent of suffering may provide a pro tanto reason to prevent them from existing. Even if there is no such reason, merely possible people do not have these rights and interests because they do not and will not exist. If we become extinct, then the world will go on without us and will be good or bad for no one.

Why do ivory-tower discussions like this matter? Because these nihilists are teaching the society leaders of tomorrow, those who will exert tremendous influence over future public policies and cultural attitudes. With our supposedly best minds suggesting that human extinction could be desirable, is it any wonder why so many of our young people seem to be despairing?

Moreover, the utter terror of suffering is pathological and leads directly to evil and/or terribly wrongheaded utilitarian policies such as eugenics and social Darwinism. It is also the moving force behind the euthanasia movement, which seeks to eliminate suffering by eliminating the sufferer. Avoiding suffering is also the central philosophical core of the transhumanism quasi-religion, which seeks to create a corporeal immortality by instilling a new eugenics with very sharp teeth.

So, what should be our attitude toward suffering? It should not be utopian scheming. Nor, to be sure, should it be indifference. Rather, we have a human duty to mitigate each others suffering, to love and suffer with each other which is the root meaning of compassion. And we can harness our own suffering to grow and become better individuals.

In this regard, for my Humanize podcast, I recently interviewed the quadriplegic Christian evangelist and disability rights activists Joni Eareckson Tada, who unexpectedly took a deep dive into this very issue, and in a very intimate and personal way. Regardless of faith issues, her attitude toward and personal response to her own deep suffering is much healthier than the nihilism that has grown so dark within utilitarian bioethics that some dont reject the prospect of human extinction out of hand.

More:

Bioethicists Okay Human Extinction to Eliminate Suffering - National Review

ACT Party’s boycott of RNZ’s Morning Report caused by host comparing one of its policies to eugenics – Newshub

The term 'eugenics' refers to the selection of desired heritable characteristics in order to improve future generations, and is often associated with Nazi Germany.

Morton's complaint against RNZ over the comment was not upheld. The BSA in April 2021 found no breaches of its guidelines for Good Taste and Decency, Balance, Accuracy or Fairness, and said the ACT Party was "treated fairly in the context of the debate".

But Morton told Newshub on Thursday the comment was the final straw for the party, and since then, no ACT MPs have appeared in live interviews for the show.

Newshub has reached out to RNZ for comment.

The boycott first came to light on Thursday morning, after The Spinoff published an interview with Seymour in which he described Morning Report as rude, selective and dishonest about what they wanted to talk about.

"After the umpteenth time that I went on their show out of a feeling of public duty and was belittled and abused with all their snarkiness, I just thought, 'I don't need this,'" he said.

But he told The Spinoff that the "really toxic and comically Lilliputian culture of Morning Report" was different from the rest of RNZ, and ACT MPs would happily appear on the station's other shows.

Morton told Newshub ACT MPs still also appear in pre-recorded interviews that are played as part of Morning Report's news bulletins.

While Seymour was happy for his party to ditch Morning Report, he decried Jacinda Ardern's decision to do much the same thing earlier this year, when she pulled out of her weekly slot on Newstalk ZB's Mike Hosking Breakfast show.

He said in March the Prime Minister was avoiding answering questions by "de-platforming" herself from the weekly slot.

"Jacinda Ardern will ultimately regret this escalating arrogance, the latest example being cancelling her weekly discussion with Newstalk ZB's Mike Hosking," Seymour said.

"It joins a long list of increasingly hubristic moves from the Prime Minister and her Government."

Ardern said the decision was made so she could branch out more to other media outlets, but broadcaster Hosking said in March that Ardern was "running for the hills" and was "over being held to account".

He said he didn't want Ardern back on his show after she cancelled the slot, which had been observed by New Zealand Prime Ministers for more than 30 years.

Often critical of the Government, Hosking said late last year people "misunderstand" his relationship with Ardern and despite often fiery interviews, he actually "likes her a lot".

"It's our work," Hosking said in December. "It's what we do. There's nothing personal in it."

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ACT Party's boycott of RNZ's Morning Report caused by host comparing one of its policies to eugenics - Newshub

Why we shouldn’t glorify Lord of the Rings – The Spinoff

Peter Jacksons trilogy has been loved by New Zealand for 20 years. Naomii Seah asks if its time we take a closer look.

Lord of the Rings is meticulously crafted, beautifully shot and visionary. The project pioneered visual effects techniques and camera work, employed over 20,000 people in New Zealand alone, and has boosted our national revenue through tourism and merchandise.

But I still dont like it.

Why? Well, for one I have the attention span of a gnat, and more than three hours per movie is just too much. But thats my own fault for watching too many TikToks.

Jokes aside, JRR Tolkien, although in many ways progressive for his time, was not immune to the rhetoric of eugenics and imperialism that permeated Britain in the early-mid 20th century. Theres been endless debate about whether Tolkien was racist. I dont care about that. But he was a British citizen, writing around the time of World War II. And it shows in his description of Orcs as squat, broad, flat-nosed, sallow-skinned, with wide mouths and slant eyes: in fact degraded and repulsive versions of the (to Europeans) least lovely Mongol-types. Its also evident in the way Orc-Goblins and Orc-Men are considered monstrous: an unpleasant echo of the mid-20th-century eugenics movement, which sought to prevent inter-ethnic marriages. Genetic determinism is also front and centre in Middle-Earth, driving its central conflict.

For a film that began production in 1997, Jackson and co sure did carry over a lot of that 1950s prejudice.

Twenty years ago may seem like a long time. Times were different in the early 2000s! I hear you yell across the internet abyss. But it had been an even longer time between the publication of The Fellowship of the Ring in 1954 and Jacksons film.

Between 1954 and 1997, apartheid and the civil rights movement had brought global attention to systemic racism. Locally, the 1970s and 80s saw an era dubbed the Mori renaissance, where indigenous arts and language flourished, as those whod had their culture beaten out of them began to reclaim their whakapapa.

Increasing indigenous activism saw a rebrand of New Zealand as a bicultural nation, and perceptions of race relations between Mori and Pkeh continued to be seen positively overseas, despite the realities of day-to-day life.

And in the midst of this swirling debate about race relations, biculturalism and equity, Jackson created a white imperialist film?

Lets unpack. Tolkien aimed to create a sense of history with Middle-Earth. Tolkiens hobbits are meant to represent domestic middle-class England; a romanticised, pastoral, simple way of life that is long gone. Hobbits are ordinary folk and in Jacksons films, ordinary folk are exclusively white or at least white-passing.

That seems particularly damaging when one considers the films positioning as part of New Zealands national identity. Are all New Zealanders meant to identify with the (white) hobbits? Its a callback to the settler culture of New Zealand in the 20th century, when Pkeh glorified the motherland and anglophilia dominated the emerging culture.

Jackson himself noted that his vision of Middle-Earth is more like history than fantasy, and in his interpretation of the texts, Jackson has made it clear that his vision of history is white.

So where are all the people of colour in Jacksons Middle-Earth? Surprise! Theyre the bad guys. The screen adaptation takes the racial coding of Tolkiens description of the Orcs and supercharges it. In the films, Lawrence Makoare and Sala Baker two of the few cast members of colour played the villainous Uruk-hai captain Lurtz, and Sauron himself. Lurtzs White hand of Saruman bears disturbing resemblance to Aboriginal body art, and the facial piercings, darkened skin and dreadlocked hair of the evil races are all cultural markers of ethnic minorities.

While Tolkien at least attempts to humanise the Orcs in his novels, theres little such nuance in Jacksons films. Orcs are born bad, from literal mud and filth, and they oppose ordinary white people.

The central irony is the close association of free peoples and nature. Its a radically revisionist interpretation of history, considering colonisation decimated the landscape of Aotearoa. So it seems extra insidious that an English, and lets face it, white narrative, which explicitly labels the north and west good in opposition to the evil east and south, has become so deeply rooted in the national consciousness.

Its a beautiful film, and for New Zealand watchers, its particularly gratifying to see local scenes displayed in breathtaking panoramic shots. But Jacksons film is not set in New Zealand. And the conflation of Middle-Earth with its English values and imperial undertones with our post-colonial nation is a troubling one. Particularly when the film, and Jackson, are placed on such high pedestals.

But its time we had a closer look at our cultural narratives. Whos writing them? Whos funding it? (Spoiler, the New Zealand army helped build Hobbiton. Make of that what you will). What are their interests? And as a nation, arent we trying to move on from the atrocities of the colonial era?

So before anyone accuses me of being unpatriotic, let me finish by clearing the air. I dont hate Jacksons work. I hate what it stands for.

Were talking about elves, dwarves, cave trolls and sneaky little hobbitses for an entire week. Read the rest of our dedicated Lord of the Rings 20th anniversary coveragehere.

Excerpt from:

Why we shouldn't glorify Lord of the Rings - The Spinoff

Time Will Tell: Three Black Scholars Ponder APA’s Apology for Silence and Complicity in Perpetuating Racism – Diverse: Issues in Higher Education

Dr. Don Pope-DavisFrom the time children enter school until they graduate, they will take a myriad of psychological and achievement tests measuring their cognitive ability and/or their intelligence quotient (IQ). In America, psychological testing and assessments have increasingly become a prerequisite for many high-stakes competitions, college admissions and scholarships, as well as for entering our national workforce. Currently, there is little evidence of these efforts abating, even in the presence of complaints by those most damaged, harmed, stigmatized and further marginalized by tests minoritized, international, linguistically different, low-income individuals and people of color. The testing industry is prolific and is as engrained in our American experience as the proverbial apple pie.

The historical proliferation of these assessments was spurred in part by French schools in the early 1900s, as white psychologists and psychometricians began to develop early theories and conjectures of learning, and to simultaneously acquire initial beliefs of intelligence, which remain today. Those children who did not pass were deemed imbeciles and removed from classrooms. The genesis of the testing movement created many tests, including the Stanford-Binet Test, which subsequently has been administered to millions of American schoolchildren. Also, all immigrants who came to the United States in the early 20th century via Ellis Island were given the Feature Profile Test on American history. Those who did not pass the test were called feebleminded and frequently sent back home.

Problematically, intelligence, aptitude and achievement tests are still used with dismissiveness. This continues a legacy of blatant disregard for cultural, linguistic and environmental influences in childrens development, resulting in subsequent interpretations and uses of scores scores that often differ across racial, ethnic, linguistic and economic backgrounds. Social scientists like Herrnstein and Murray seized the moment in 1994 to capitalize on polemic, deficit-oriented and racist beliefs in their highly supported and highly contested book reminiscent of eugenics advocates.Dr. Donna Y. Ford

Within this context, the American Psychological Association (APA) recently issued a long-overdue apology for the harm the organization and its member psychologists have done in perpetuating systematic racism and its complicit role in exacerbating myths around racial hierarchies, particularly regarding Black communities. APA acknowledges its role in perpetuating racism under the guise of science and the faade of objectivity. The association now more directly proclaims that race is a social construct with no underlying genetic or biological basis.

As Black scholars and leaders in psychology, counseling and education, we strive to expose and mitigate barriers that regularly inhibit educational progress and outcomes for Black and other vulnerable groups. With this in mind, we challenge prevailing moral and social beliefs that permeate institutions. We endeavor to shape more reasonable and moral standards that address structural racism that has served to maintain the status quo.

The Association of Black Psychologists also issued a response. They concluded: To accept the APAs apology would be to accept the accuracy of a fabricated historical record and negate the mission and vision of the Association of Black Psychologists. To our disappointment, to date, responses from other professional organizations are noticeably absent. One exception is theAmerican Psychiatric Association.

Individuals and organizations should not be silent. Instead, we must speak truth to power and work in coalition toward a path forward, proactively and unapologetically grounded in anti-racism. The healing is in the pain. We believe that APA leadership, in collaboration with other organizations, should take a next step by establishing a Truth and Reconciliation Commission similar to South Africas in 1995. That commission helped accelerate the healing process in the aftermath of apartheid. This will take effort, but the urgency of now is upon us.

Regardless of APAs apologetic treatise, the lethal effects of oppressive psychological science still exist and remain an often-debilitating force in the lives of Blacks and other communities of color. Out of psychology and education have emerged a series of theories, tests, beliefs and practices that permeate every facet and level of the American education system, preschool to postsecondary and beyond. The work of early White psychological science pioneers such as Alfred Binet, Lewis Terman and Carl Brigham spawned an array of aptitude tests, achievement assessments and college entrance examinations that still dictate the educational and vocational options for millions worldwide.

Such tests often normed on the experiences, verbal and non-verbal language and culture of White people favor White, upper-income individuals while disadvantaging other demographic groups. Even with test revisions and updates, they continue to fall short in equitable and culturally responsive ways, as witnessed by limited educational access afforded to students of color and English Language Learners. It is no wonder that we and many scholars still call for more effective and inclusive systems of assessments.Dr. James L. Moore III

Let us be clear. The tests are not the sole issue. Instead, the issue is how people professionals use them in isolation of other critical information. The results are often taken too literally by educators, who use the tests to validate their expectations of minoritized groups. Reification is prevalent. They are used to hinder access togifted and talented programs, courses for advanced learners and access to higher education in general. Conversely, how tests are used plays a dominant role in the over-representation of Black students in stigmatized categories of special education. This is associated, along with excessive disciplining and hyper-policing of Black bodies in academic settings, with the school-to-prison pipeline.

The high-stakes decisions made by testing are carried by students for a lifetime. And so, the missteps outlined in the APA apology continue to reverberate through American schools, impacting our children, their potential and outcomes, as well as the achievement and progress of our entire nation. Therefore, the attitudes and perceptions about minoritized groups must be examined, and a systematic review should be undertaken of training and pedagogical approaches used in educational institutions.

The associations apology should have happened decades ago. The opportunity presented itself when the Civil Rights Act passed, during so many discussions of psychological health and well-being and, nearly two years ago, when George Floyd was murdered. Because of the outsized influence of psychology in other disciplines, organizations should self-examine and follow suit, including the National Association for Gifted Children, Council for Exceptional Children, National Association for the Education of Young Children, American Educational Research Association and the American Counseling Association, to name a few. All have observed their members impact on education and life outcomes using misguided science rooted in racist ideology. It is time to come clean, recognize our complex history and outline a path forward that is indicative of an authentic and sincere apology that leads to new possibilities.

Issuing statements does not fix the historical harm done. To make meaningful change, we must do the hard and messy work of examining the impact and finding commensurate solutions by going deep and wide. Lukewarm, band-aid solutions will not suffice. Gone is the time for allyship that only leads to more webinars with little outcome and accountability. The APA and education field can broadly begin here: Assess who uses psychological tests today, and how. Examine how life-changing decisions are made based on the results. Evaluate how their implementation allows some people to treat others unjustly.

We have the research tools and, hopefully now the will, to guide education, psychology and other disciplines toward equity and inclusive excellence. But the question remains: Will we take this crucial opportunity to do more than simply say, Were sorry? Now, more than ever, we must move along the arc of the moral universe.

Dr. Don Pope-Davis, is Dean of the College of Education and Human Ecology at The Ohio State University

Dr. James L. Moore III, is Vice Provost for Diversity and Inclusion and Chief Diversity Officer at The Ohio State University

Dr. Donna Y. Ford, is Distinguished Professor of Education and Human Ecology, at The Ohio State University

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Time Will Tell: Three Black Scholars Ponder APA's Apology for Silence and Complicity in Perpetuating Racism - Diverse: Issues in Higher Education

Opinion: Dont be fooled. Zionism is an Indigenous rights movement and being anti-Zionist is antisemitic. – The San Diego Union-Tribune

Danzig served in the Israeli Army and is a former police officer with the New York Police Department. He is an attorney and active member of StandWithUs, where he is the local advisory board president, and Herut North American, where he is a national board member. He lives in Del Mar.

On Oct. 26, the San Diego Unified School District Board of Education passed a resolution condemning antisemitism, as its defined by the International Holocaust Remembrance Alliance (IHRA), and as requested by every synagogue and mainstream Jewish organization in San Diego. Since then, Israel-haters in San Diego have been wringing their virtual hands over the audacity of a school district to define antisemitism the way most Jews define it (in a state that over the previous five years saw a 40 percent increase in antisemitic hate crimes, and in a country where Jews are the targets of 60 percent of all faith-based hate crimes).

Recognizing they cant simply say that they oppose such resolutions because Israel-haters want to exploit Jew-hatred in order to incite hatred against Israel (the worlds only Jewish state and home to nearly half of the worlds Jews), the Israel-haters wax apoplectic about how the IHRA definition chills free speech because it supposedly makes legitimate criticism of Israel antisemitic, is a tool for weaponizing antisemitism, and will somehow increase anti-Arab or anti-Muslim hatred.

I addressed why these claims are specious and themselves antisemitic in an an essay last month.

Likely because the IHRA definition in pertinent part provides it is antisemitic to deny the Jewish people their right to self-determination, e.g., by claiming that the existence of a State of Israel is a racist endeavor, we are seeing claims that being anti-Zionist is not antisemitic, as well as claims by Israel-haters actually comparing Zionism with racist colonialist ideologies like Manifest Destiny (which was used to justify Americas westward expansion and brutal conquest of Native Americans).

These claims are false and also incredibly insulting to the vast majority of Jews, who either are Israeli or feel a very strong attachment to Israel. Moreover, these claims get to the core of why the Arab-Israeli conflict persists, and why, despite at least eight different peace and partition offers since 1937 (to create the first independent Arab state west of the Jordan River), no such offer has ever been accepted.

While the Israel-haters try to redefine Zionism to make it seem somehow equivalent to colonialist ideologies like Manifest Destiny, the truth is that the definition of Zionism is quite simple: Zionism is the belief that the Jewish people, like all other peoples, have a right to self-determination and sovereignty in part of their Indigenous homeland.

Not only is there nothing in the definition of Zionism that believes Jews are superior to any other people or race, the idea of Jews being Zionist and even willing to fight for their right to be sovereign in their homeland predates the phony European concept of race by over 1,500 years. We just finished celebrating Hanukkah. While many Americans may think Hanukkah is a Jewish version of Christmas, or just a fun, candle-lighting, jelly-donut-eating holiday, that would be incorrect. Not that Hanukkah isnt fun (it is), but at its core, Hanukkah is a celebration of a successful Jewish revolt in the land of Israel and the reestablishment, after centuries of Greek colonial rule, of Jewish sovereignty and self-determination in Zion (another word in Hebrew for Jerusalem).

Nearly 300 years after the successful Jewish revolt against the Greek/Selucid Empire, the Jewish peoples Zionism led to other Jewish revolts against colonial rule, this time against the Romans. From those ultimately unsuccessful revolts, archeologists have found numerous Judean coins, including coins inscribed in ancient Hebrew with the words: Freedom for Zion. It is that longing for freedom in Zion, the 3,000-plus year history of the land of Israels centrality in the Jewish peoples faith, culture and consciousness, coupled with the sad reality that the Jewish people have been regularly subjected to deadly discrimination and oppression in almost every land in the Diaspora, which led to the 19th century political movement called Zionism. And when Israel gained its independence in 1948, Zionism became the worlds first successful Indigenous movement of a dispossessed and colonized people regaining sovereignty in their Indigenous homeland.

Like many Indigenous peoples throughout the world, Jews were consistent victims of European oppression and violence for centuries, precisely because they were perceived as not being a part of the superior European world beginning with the Greek colonialization and attempted Hellenization of the land of Israel and continuing through World War II when over 6 million Jews were murdered. Throughout this time period, the Jewish peoples dream of freedom in Zion and for sovereignty in the land of Israel (what the Romans called Palestina) never waned. It is why at every Passover seder, and in countless other prayers, the Jewish people have regularly prayed and sang in Hebrew about their longing for a return to Zion.

It is this context that makes the arguments of the I am only anti-Zionist antisemites so clearly hollow. As Zionism simply stands for the proposition that the Jewish people have a right to sovereignty in part of their Indigenous and historical homeland, saying you are anti-Zionist, but not anti-Jewish, is the equivalent of saying you are not anti-Maori, but only want to deny the Maori any sovereignty in their Indigenous lands, or that you are not anti-Algonquin, Mississaugas, Odawa, Oji-Cree, Ojibwe, or Potawatomi, you just hate the Anishinaabe movement for a sovereign Native American state called Anishinaabaki.

As for those dishonestly comparing Zionism with Manifest Destiny, or other supremacist forms of colonialism, it bears noting that when the descendants of the English, French and Spanish conquered and colonized North America, they never discovered a single archeological finding written in ancient English, French or Spanish; but archeological artifacts written in Hebrew and referring to Jewish kings, Jewish prayers (that Jews still say to this day) and even to ancient vitners in the land of Israel are ubiquitous.

What the I am only anti-Zionist antisemites also ignore (or more aptly seek to deflect attention from) is how closely anti-Zionist tropes track antisemitic tropes, which for centuries were used to incite discrimination and violence against Jews.

The 19th-century antisemite demonized Jews, among all peoples on Earth, as the primary cause of the worlds problems. Anti-Zionists demonize Israel, the Jew among the nations, as the primary cause of the worlds problems. For the 19th-century antisemite, Jews were bloodthirsty baby killers. Anti-Zionists routinely demonize the one Jewish state as a bloodthirsty baby killer. The 19th-century antisemite demonized Jews as being nefariously in control of banks, the media and governments. Anti-Zionists regularly demonize Israel or Zionists as controlling the banks, media and foreign governments. The parallels are clear.

But the most antisemitic aspect of the anti-Zionist creed has to be the ubiquitous attempts to erase Jewish history and to tar Zionism as a colonialist endeavor. George Orwell famously said, The most effective way to destroy people is to deny and obliterate their own understanding of their history.

That erasure is at the core of anti-Zionism. It is also at the core of the Arab-Israeli conflict. Because ultimately, the anti-Zionists claims about colonialism are what psychologists refer to as projection. In the seventh and eighth centuries, Arab armies from the Arabian Peninsula conquered and colonized all of the Middle East and North Africa (MENA). Since then, their descendants, just like the descendants of Europeans in all of the lands conquered by Europeans, have generally resisted all Indigenous rights and independence movements. It is why over the past millennia, there has never been an independent state for the Kurds, Amazigh, Copts, or any other Indigenous people in the MENA (other than the Jewish people).

Antisemitism is the oldest form of bigotry. For over 2,000 years. it has led to countless expulsions and murders of Jews. Today, it includes anti-Zionism, a hatred of Jewish sovereignty and of the ability of Jews to defend themselves in their own state. Many want to paint this hatred as somehow being progressive, when the core motivation behind this hatred is a regressive desire to destroy the one successful Indigenous rights movement in the MENA, and to once again make Jews stateless and defenseless. No one should allow themselves to be taken in by such counterfactual duplicity.

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Opinion: Dont be fooled. Zionism is an Indigenous rights movement and being anti-Zionist is antisemitic. - The San Diego Union-Tribune

Fact check: Nazi scientists brought to U.S. in Operation …

NASA's Perseverance rover hopes to discover ancient life on Mars

NASA's Perseverance rover is equipped with two microphones, 23 cameras, seven scientific instruments, plus a drone helicopter.

USA TODAY

There have been many events, both big and small, that have shaped U.S. history.Among them, a Facebook post claims, is a secret U.S. program that recruitedNazis.

A modified version of thepopular meme of Homer Simpson vanishing into a hedge depictsSimpson bearinga swastika on one shoulder and an arm extended in a Nazi salute. "World War II: ends," reads the text above, which goes on to suggest former "Nazi scientists" subsequently shifted overto NASA, as illustratedbySimpson reemerging in a T-shirt emblazoned with the agency's distinctive logo and a red baseball cap with the America flag.

The sentiment within the comments seemedlargely accepting of the claim.

"What was the alternative for them?" asked one. "Since herr fuhrer (sic) liked to shoot people..."

"Art imitates life," wrote another sharing a GIF featuring images from the Marvel movie franchise of an evil Naziscientist character and a newspaper clippingwith the headline "Germany scientists recruited by U.S.".

USA TODAY awaits comment from the Facebook user who postedthe meme in the public group Official Flat Earth & Glove Discussion.

In 1945, the Joint Intelligence Objectives Agency, a subcommittee established by the Joint Intelligence Committee of the Joint Chiefs of Staff, was tasked with retrieving German scientists, doctors and engineers who were identified as intellectually vital to the Third Reich.

Journalist Annie Jacobsen statesin a 2014 interview that this was prompted by the Allies'concerns overHitler's potential weapons arsenal.

"Fall of 1944, right after the Normandy landings, scattered among the Allies'troops are these little units of scientific intelligence officers and they're working to find out Hitler's biological weapons, his chemical weapons and his atomic weapons," said Jacobsen, author of "Operation Paperclip: The Secret Intelligence Program to Bring Nazi Scientists to America."

These intelligence officers eventually discovered while the atomic weapons program wasnot as advancedas initially feared, Hitler's biochemical weapons were. The hunt "for this scientific treasure and ultimately for the scientists themselves" thus ignited Operation Overcast, renamed Paperclip for the paperclips attached to the files of the most "troublesome cases," Jacobsen writes in her book.

The U.S. was not alone in this endeavor. Britain, France and especially the Soviet Union sought to enlist these German scientific experts, as well. A U.S.-Soviettechnological rivalry marked by the Space Race and Cold Warwould also serve as amotivation, and justification, for Operation Paperclip's existence.

By the fall of 1945, German scientists starting arrivingon U.S. soil. Not all the men recruited were Nazis orSS officers but the most prominent and valued among them were, having worked either directly with Hitler orleading members of the Nazi Party, such asHeinrich Himmler and Herman Gring.

Wernher von Braun, a rocket engineer, was instrumental in developing the first U.S. ballistic missile, the Redstone, and later the Saturn V rocket while serving as director of NASA's Marshall Space Flight Center. As a Nazi ideologue and member of the SS, hetraveled to the Buchenwald concentration camp, where he "handpicked slaves to work for him as laborers," said Jacobsen in a 2014interview with NPR.

Hubertus Strughold, a physiologist and medical researcher, headed the German Air Force Institute of Aviation Medicine, known for its torturous medical experiments on inmates from the Dachau concentration camp. Strughold claimed ignorance of any such activity until after the war, yethe appeared among a list of 95 doctors at an October 1942 conference discussing their findings. In the U.S., he was chief scientist of the aerospace medical division at Brooks Air Force and has since been credited as the father of space medicine.

Walter Schreiber, a former Nazi general, also oversaw inhumane medical experiments involving bioweapons that resulted in countless of deaths. Following the war, he was captured by the Soviets but defected to the U.S. He worked for various government entities before finally settling in Texas atthe Air Force School of Aviation Medicine, Jacobsen writes.

While Schreiber would later serve as a witness during the Nuremberg trials, he, von Braun, Strughold and the rest of their fellow Nazis brought to the U.S. would never be held accountable for their own atrocities. Operation Paperclip remained secretthroughout much of the Cold War.

We rate this claimTRUE because it is supported by our research. Operation Paperclip was a secret initiative launched by the U.S. government to recruit German engineers, doctors, physicists,chemists and other scientific experts for U.S. technological advancement, especially in anticipation of the Cold War. Many recruited German scientists did work for NASA and various other government entities. They were not held responsible for their war crimes.

Thank you for supporting our journalism. You can subscribe to our print edition, ad-free app or electronic newspaper replica here.

Our fact check work is supported in part by a grant from Facebook.

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Fact check: Nazi scientists brought to U.S. in Operation ...

80 years ago this month, Nazis invented industrial murder at quiet Chelmno – The Times of Israel

When the Nazi death camp Chelmno began operations 80 years ago this month, a new phase of the Holocaust was launched in a small Polish village along the Vistula River.

At Chelmno, home to 35 families, the German SS pioneered methods of mass murder later deployed at death camps including Auschwitz-Birkenau. Known as Kulmhof in German, the killing site was also home to experiments in corpse disposal on an industrial scale.

In the Reichsgau or Nazi-made administrative subdivision of Warthegau, which surrounded Chelmno and included industrial Lodz, the Germans played elaborate shell games to deceive victims and bystanders. Tactics included issuing contradictory messages and forcing victims to send postcards with fake destinations.

The SS covered up where the Jews were going to, said historian Nicholas Terry, a senior lecturer in history at the University of Exeter. The theme of deception and secrecy allows us to see what it meant for the perpetrators, the bystanders, and the victims.

The first Jews gassed at Chelmno were deported from provincial ghettos during early December 1941. For many months into 1942, most Jews in the Warthegau regions 57 ghettos believed deportees were headed for labor and resettlement.

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Among Nazi death camps, Chelmno was the first to deploy gas. Inside custom-rigged mobile killing vans, vehicle exhaust was funneled into a sealed compartment where up to 50 victims were packed. At least 172,000 Jews were murdered at Chelmno during two periods of the camps operation, as well as 5,000 Roma and Sinti people.

Memorials at former Forest Camp at Chelmno, where victims were buried and later cremated, 2017 (Elan Kawesch/The Times of Israel)

To confuse the outside world as well as Jews imprisoned in the regions ghettos, some transports were sent back and forth between for example Germany, Lodz, and places east of Lodz, camouflaging Chelmno as the true destination.

These reports of Jews being resettled were widely believed outside Europe, Terry said. And at the end of the war, there was a hope against hope that more Jews had survived.

The German strategy of toying with the outside world inevitably led to degrees of self-deception among victims and bystanders, said Terry. For example, only after the Germans demanded the Lodz ghetto Jewish council hand over thousands of children for deportation did most Jews realize resettlement meant death.

War crimes investigators examine a burned-out mover van near Chelmno, of the type used by the SS to murder people (public domain)

The uncertainty has not been emphasized as much, in terms of the bystander responses, said Terry, adding that Chelmno has been overshadowed in general.

It is one of the best-documented killing sites, said Terry, pointing to German documents, among others, on materials used to make field ovens that cremated corpses. There are also a multiplicity of eyewitness accounts of gassings at Chelmno, said Terry, including one given by a Jewish prisoner who escaped the death camp in 1942 and fled to Warsaw.

At Chelmno, Jews were taken to a dilapidated schloss, or castle, and greeted in the courtyard by the so-called squire of the manor.

For the first time in the Holocaust, people were told they must take disinfection showers before the journeys next stage. After being forced through a narrow corridor in the basement, victims were packed into what appeared to be a small room.

Jews en route to Chelmno death camp from Kolo, where they transferred to a narrow-gauge rail and wagon cars (public domain)

Before people had time to react, the wagon was sealed and the engine started. After a 20-minute drive through town to the Forest Camp, the asphyxiated victims were unloaded and buried by Jewish prisoners. Every few weeks, the team of prisoners was executed to ensure secrecy.

The role played by Chelmno in the Holocaust was pivotal, researcher Chris Webb told The Times of Israel. For example, the camps first commander Herbert Lange was an absolute pioneer in the development of gas vans.

An amateur historian, Webb has researched Chelmno and the threeAktion Reinhard (Operation Reinhard) death camps Belzec, Sobibor, and Treblinka for more than 40 years. His books include The Chelmno Death Camp, co-authored with the late Artur Hojan.

The only difference between Chelmno and the Aktion Reinhard camps is that Chelmno used vans instead of static gas chambers, said Webb.

German soldiers help deport Jews from Zychlin ghetto to Chelmno death camp (public domain)

After the three Reinhard camps surpassed Chelmnos capacity for murder in the summer of 1942, SS officers reinvented the village-based killing center with a new task: Germany might not win the war, so evidence of the Final Solution specifically corpses had to be exhumed and destroyed at death camps and hundreds of mass graves throughout Eastern Europe.

At Chelmno, Paul Blobel of the SS carried out gruesome experiments involving flamethrowers and incendiary bombs. Eventually, he settled on using railroad tracks stacked with layers of corpses and firewood. Methodically, Blobel created improvised crematoria that were more sophisticated than crematoria at the Reinhard camps, said Terry.

Chelmno is arguably the most obscure death camp, but there are more physical traces of the Holocaust at the village than exist at most killing sites, according to experts.

Schloss manor house converted into part of the death camp at Chelmno, as seen in 1939, two years before the SS began using mobile killing vans on-site (public domain)

Theres more to see at Chelmno than at Treblinka, said Webb, referring to the Aktion Reinhard camp where 900,000 Jews were murdered. At Treblinka, no structures associated with the genocide stand today. Decades ago, 17,000 quarry stones were placed atop the mass graves to evoke communities destroyed there.

By way of contrast to Treblinka, Chelmno remains largely as it looked during the war, including the church where victims were held overnight during summer 1944 transports from Lodz. The manor house was blown up by the Nazis in 1943, before the camps second phase of operation, but the basements foundations and a staircase have been excavated.

From the perspective of Terry, Chelmno is a spatially diffused site with a staggeringly multi-staged killing process, he said. Its almost a misnomer to call it a camp. Its an extermination site.

Despite Chelmnos confusing layout, it was easy for villagers to piece together what took place there, said Terry. In the spring of 1942, townspeople witnessed victims falling out of an overturned gas van. For months, stench and smoke wafted in from the Forest Camp cremation pyres, while the camps German guards were billeted with families in town.

War crimes investigation photo of Jewish victims belongings left at the Kolo synagogue, where Jews were imprisoned overnight before transport to the Chelmno death camp (public domain)

Chelmnos SS officers worked toward the Fuhrer Nazi-speak for administrators to anticipate and execute Hitlers orders beforehand. When it came to solving the Jewish question, Chelmnos leaders improvised the transition from open-air massacres in the east to what became death camps with fixed gas chambers, a more centralized and discreet model.

At Chelmno we saw there was a degree of decentralization and improvisation in the genocide of European Jews, said Terry. Regional authorities could improvise or experiment.

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80 years ago this month, Nazis invented industrial murder at quiet Chelmno - The Times of Israel

How European Jewish refugees wined and dined Nazi prisoners for US Army intelligence – The Times of Israel

There was something unusual about the five men who walked into the Jewish-owned Lansburgh Bros. department store in Washington, DC, one December day in 1946. Four wore long leather coats and Tyrolese hats, and spoke German to the fifth man, saying they wanted to buy Christmas gifts for their families sweets for their children and unterwasche, or undergarments, for their wives.

They started a mild altercation after becoming frustrated with their inability to communicate with the staff, and in a climate where World War II was still on everyones minds, the local military police were called in to arrest them. Ultimately, the five were brought back to where they had come from a clandestine prison camp in northern Virginia known only by its address: PO Box 1142.

What no one knew least of all the many Jews who frequented Lansburgh Bros. was that the quartet in German dress were actually high-ranking Nazis who had been apprehended by the United States during the war, including Hitlers chief rocket scientist, Wernher von Braun.

The military brass at PO Box 1142 believed that if its Nazi prisoners received lenient treatment, they would divulge top-secret scientific information that would benefit the US in the Cold War against its new enemy, the USSR. The prisoners request to go Christmas shopping in the capitals largest department store went all the way to the Pentagon.

Not only was the request accepted, but the quartet got $1,000 in spending money and an escort a guard named Arno Mayer. In the strangest part of the story, Mayer and many of the guards playing good cop at the camp were young Jewish refugees who had fled an increasingly antisemitic Europe.

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The guards little-known narrative is spotlighted in a new animated Netflix short film, Camp Confidential: Americas Secret Nazis, directed by the Israeli husband-and-wife duo Daniel Sivan and Mor Loushy. The 35-minute film premiered on September 24.

A still from the new Netflix animated documentary Camp Confidential: Americas Secret Nazis. (Courtesy of Netflix)

At first the story sounded so bizarre and unreal we could barely believe it that [there was] a secret Nazi camp near Washington, DC, run by Jewish refugees, Sivan and Loushy wrote in an email. It took us some time to understand this is not a fictional story, but actually happened.

They reflected, This story involved so much absurdity, pain and double standards on behalf of the US we felt this story must be told, and brought to a wide public this hidden part of history couldnt stay buried, known only to history buffs. We believed it should be known to all and of course Netflix was the best stage we could dream of.

Due to the scarcity of archival footage from the top-secret camp, the film uses animation to tell the story. This includes an animated version of a young Mayer and his efforts to keep prisoners happy. In one scene, the ex-Nazis enjoy an indoor Christmas celebration while a bitter Mayer stands outside, refusing their offer to come in for a drink.

In a joint Zoom interview with The Times of Israel, the directors recalled their initial doubts about the accuracy of the story.

Mor Loushy, co-director of the new Netflix animated documentary Camp Confidential: Americas Secret Nazis. (Courtesy of Netflix)

OK, it was probably like an urban legend, a myth, Sivan remembered thinking.

Loushy said that she could understand if it happened after the war, but to realize it [had already begun] in 1942 was shocking to us.

Daniel Sivan, co-director of the new Netflix animated documentary Camp Confidential: Americas Secret Nazis. (Courtesy of Netflix)

The directors credited producers Jono and Benjamin Bergmann with bringing the decades-old story to their attention and then confirming it by locating an archive of oral history interviews with some of the former guards.

The Bergmanns had originally learned about the story from a German journalist and colleague. In addition to the oral history archive, they also sought to find surviving guards to interview in real life. Because so much time had passed, they could only locate one Mayer.

Just days before Sivan and Loushy were to fly from Los Angeles to New York en route to interview him, they learned there was another survivor a fellow Jewish refugee, Peter Weiss. Finding him took some sleuthing.

As the youngest in the group, we had a hunch that Peter Weiss might still be around as well, the producers said in a statement. We ended up finding him believe it or not by going through all Peter [Weisses] in the New York phone book until we found one that was over 90 years old and originally from Vienna.

As it turned out, Mayer and Weiss knew each other.

Their shared experiences refugees from Europe and a secret to be kept from everyone in their lives created a very close bond at [the camp], the Bergmanns said. They stayed in touch and visited each other for many years after that.

It seems like Arno and Peter are the only survivors, Sivan said, noting that since the films release, he and Loushy have gotten a lot of messages from family members saying their dad was also part of [the camp] We discovered more and more stories of course, about people who already passed away.

It was Jewish refugees proficiency in German that got the army interested in them as interrogators. In the film, Weiss recalls proving his knowledge by quoting Goethe. Many were originally recruited for their language skills as part of the much larger group of Ritchie Boys European emigres who trained at Camp Ritchie in Maryland in such aspects as extracting intelligence from German prisoners of war.

At PO Box 1142, one guard tricked a German prisoner into thinking he was about to be gassed, which prompted him to divulge information. Intelligence obtained from the camp reportedly included the location of von Brauns subterranean V2 rocket factory at Peenemunde, which subsequently became the target of Allied bombings.

As the war neared its end, the geopolitics became complicated. Von Braun and 300 of his colleagues at Peenemunde were captured by the US and secretly brought stateside in contravention of official American policy first to an island in Boston Harbor, then to PO Box 1142.

We had very little information about rocketry, Mayer says in the film. Rocket scientists were essential to our war effort [in the Cold War].

A still from the new Netflix animated documentary Camp Confidential: Americas Secret Nazis. (Courtesy of Netflix)

The camp brass created a new position for Mayer morale officer and asked him to make life enjoyable for the prisoners, hoping this would get them to cooperate. He gave the prisoners newspapers to read, whiskey to sip and numerous games to play, including swimming, tennis, ping-pong and chess. He taught them horseshoes and discovered they loved volleyball.

[The guards] were all shocked, Loushy said. They didnt understand. They were so ready to go and fight in Europe, be really active saving their families. Yet they found themselves in the camp playing ping-pong with Nazis.

The Jewish soldiers knew about the evils the Nazis had committed, including against their families. The filmmakers stated that many of the soldiers had arrived in the US as enemy aliens and their US citizenship depended upon their military service.

Almost all [of us] were refugees from the Nazis, Weiss says in the film. We would have preferred to treat them as the war criminals they were. In the army, you can only follow orders. I tried to suppress my rage. He states that he was not fully aware of the enormity of what had happened under the Nazi regime, but notes, My grandfather, uncle, aunt, cousin, other relatives all died in the Holocaust, like so many others.

A still from the new Netflix animated documentary Camp Confidential: Americas Secret Nazis. (Courtesy of Netflix)

Newsreel footage is shown proclaiming the first actual pictures of atrocities in Nazi murder camps, including an appalled Gen. Dwight D. Eisenhower surveying liberated Buchenwald, where tattooed slave laborers had worked on V2 rockets.

Mayer is quoted saying that the V2 rockets killed countless numbers of people in London and that building them required Jews arrested by the Gestapo. [Von Braun] knew what was going on. He knew there was an Auschwitz.

The film incorporates footage of von Brauns unlikely career resuscitation in the US decades later, as a well-respected NASA administrator. Clips show him overseeing the Apollo project to put the first man on the moon and getting cheered by crowds.

According to the film, the prisoners at PO Box 1142 were never charged with war crimes, and many went on to careers at NASA and the CIA. The camp was eventually bulldozed, and its former guards generally stayed silent about their duties there.

A sizable number of the guards went on to noteworthy achievements in later life. Weiss pursued a career in human rights law, including at the UN, where he helped regulate against torture. Mayer joined the faculty at Princeton and wrote several controversial books, one on the Holocaust and another on Zionism.

Weisss commitment to human rights and regrets over his work at the camp is reflected in his final comment in the film about the question of whether you can do bad things to achieve good ends. I would say if you do that, the end that you achieve is not worthwhile.

Excerpt from:

How European Jewish refugees wined and dined Nazi prisoners for US Army intelligence - The Times of Israel

Mixed-race cop on policing in 2021: Ive been called racist and a Nazi – New York Post

In this era of civil unrest and partisan politics, its harder than ever for cops particularly black cops to do their jobs. In this excerpt from the new book Beaten Black and Blue: Being a Black Cop in an America Under Siege, Ray Hamilton, 42,reveals his experiences working as a mixed-race cop in San Ramon, Calif., east of Oakland, as well as his early days serving in Washington DCs tough Sixth District.

A big part of my story is that Im black and white, and that puts me right in the middle of all the race and policing issues.

And, yes, Ive dealt with different aspects of racism. On a routine traffic stop, people might say, Oh, you just stopped me because Im black.

Really? Because Im mixed race, and sometimes, you cant tell what I am.

On the East Coast, they thought I was Puerto Rican, and here in California, they dont know what I am. Theres no box to put me in, which I think is true for a lot of people. So when that happens, I call people out on that. I ask them, Could it be that I stopped you because your tail light was out, or your tags expired a year ago, or you ran a red light? It couldnt be anything like that?

That usually turns things around.

I never saw myself as looking tough or like a thug; I had curly hair and an olive skin tone. But when I was a teenager, I got stopped by the gang unit in Dallas a true felony stop with guns drawn and everything.

Put your hands on the steering wheel!

Whoa, I thought. What in the world is happening?

Youre in a gang!

No, I wasnt, and I never was. However, my cousin was in a gang, and he used to get caught up in all kinds of criminal stuff. He ended up getting shot five times, and died.

All of that really turned me away from being in a gang or doing anything criminal.

Instead, I ended up in the military. I was in the Air Force working for the Department of Defense on Bolling Air Force Base. At the time, I was working as a sports and recreation assistant, creating extracurricular events for the Air Force community.

I believe how you do your job is more of a calling than what your job actually is. And for some reason, after the military I decided I was going to apply to the DC Metro Police Department. They werent hiring at the time, and several people advised me not to join that dirty police department. I applied anyway, and I waited. I waited for two years. Most people apply to multiple departments to increase their odds of being hired. Me? I only applied to one. I believed I was supposed to work there. Eventually, after their hiring freeze was lifted, I became one of 35 people hired out of 10,000 candidates.

Thats how I started my career with the police 10 years ago.

When a person of color calls me a racist, I feel bad for them. Its like theyre conditioned to believe people treat them a certain way because theyre black.

When a person of color calls me another person of color a racist, I feel bad for them. Its like theyre conditioned to believe people treat them a certain way because theyre black. I want to say to them, Wait a minute. You dont want me pulling you over because you have your hair in cornrows, you have tattoos, youre smoking a blunt, but you dont want me to assume youre a gangster, right? You dont want me to assume that, but thats one of the first things that comes to mind. But thats not reasonable for me to do that. Thats me judging you, and you dont want me doing that. Why judge me?

During the recent riots, I was accused of being an overseer, someone who watched over slaves. Another time, someone accused me of being like the Nazis marching the Jews off to the concentration camp trains, as if I were marching people off to be killed. I was surprised by that. It really does get that dirty sometimes.

When I have on riot duty gear or the uniform in general I remember Im not here representing myself; Im here to try to keep some kind of peace. When Im wearing either one, I dont represent myself or my own ideas and thoughts. Im there to protect whatever brothers and sisters are around me.

Were not there to control people. They should feel free to protest all they want. I may even agree with them, but I dont agree with all the methods. And I cant let a few opportunists cause this thing to become a mob and be unlawful.

I think its important to hold that attitude.

Recently, a couple of guys on the line took a knee. No, no, brother! You cant take a knee when youre on the line, whether you agree with them or not. You cant take a knee because that puts everyone else at risk now. Its very awkward. Its not the time, and then it looks like were not standing together.

When Im in the uniform, Im there for a greater purpose. That purpose is to keep some kind of peace and maintain some kind of order, and to do that, you have to show some kind of solidarity.

That said, I also want to build a rapport with the community I serve. When I was in DC, especially in the project area, I was dealing with a different mindset. And I knew you had to meet them where they were and build that relationship. The beat I had was a very rough four blocks where there were murders, drug deals, you name it. I had a partner, a white dude from Arizona. Hed never been around that many black people, and this was an all-black neighborhood. When we walked that beat, my partner kind of walked behind me. You could visibly tell he was scared. I had to explain to him, Dang, man, theyre gonna pull your card if you walk behind me. Dont do that. If they see youre scared, theyll respond in a bad way. You gotta walk beside me, not behind me.

Since Im in the middle black (and white) and blue I find myself walking the line.

I know some officers have bad attitudes about the communities they serve. Yes, its often a racial divide. Some of the white cops had a different outlook. They even made patches: Were not stuck here with you; youre stuck here with us. And sadly, yes, I have heard some of the guys refer to black people as savages. Im thinking, My gosh, how are you going to deliver or render any kind of justice or service to this community if you refer to them as savages?

So, Im trying to win over the white officers and the black community.

Sadly, I do understand why some people hate us.

On one occasion, a black officer stopped a guy who was a known criminal. Everybody knew he dealt drugs, and he had drugs on him. But the officer demeaned him, I guess trying to teach him a lesson in front of the other people in the area. He made him kneel down on the concrete (that hurts), and he had him down there for more than five minutes. The crowd felt like the cop was showing off and abusing his authority. So, they started name-calling called us the slang term for cops, twelve, called us FEDS, called us all kinds of names. I believe when you name someone like that then theyre no longer a person. Like calling someone a savage or shouting out, F twelve either side of the argument theyre no longer a person.

Not too long after that, we caught a guy on a very minor misdemeanor charge, riding a dirt bike in the city. These rough riders would ride dirt bikes and ATVs in the city, and the cops would chase them. I caught this one guy, and we were just going to write him up, get his fingerprints, and process him out, but this guy had a $10,000 wad of bills on him. He claimed it was from his family business. But I know that most businesses usually dont transport cash in their waistbands. I needed to hold the money until he could bring down receipts to prove it was earned through that business. He started yelling at me that he wanted to see it put in the evidence bag. I was surprised. Did he think I was going to steal it? Apparently yes, because other cops in my district had been fired for misconduct. No wonder he didnt trust us!

I can sometimes understand the lack of trust from the community, but when you dont feel you have the support of your leaders, thats when it gets really hard. When I was on the riot team in DC, we werent able to wear our full riot gear because it looked too aggressive. Here in California, its more of the same. During one of the riots, I was hit with a bottle, and we had to shoot a rubber round back at that person. Then, we had to use tear gas to disperse the crowd. Three days later, they took away our tear gas. I was recently deployed to Sacramento, and we were told that if protesters break the windows at City Hall, we should let them.

Even in Oakland, we had to let them loot a Target, a 7-Eleven store, and a car dealership.

I know all the violence and looting are coordinated, because I saw someone watching us and monitoring our movement. Then, he called it to his fellow rioters. Not being able to do anything or take any action when laws are being broken and officers are being hurt? Thats demotivating. You end up getting what we call 4 percent. Some officers go out on duty, but they wont be proactive, and they give less than 100 percent because its a reaction to feeling powerless and not being supported. Theres also a threat of being sued by someone, even if the officers are just defending themselves. Its very disheartening.

While I grew up feeling like I never had to be anyone but who I was, these days, I feel like I am always being forced to pick a side. I try to identify with the people I work with, and I also try to identify with the community Im policing. I dont want them to feel like I said, that Im just here as an overseer. Im not here to fine you and arrest you, but I have a job to do. It can be hard to feel so stuck in the middle.

Reprinted with permission from Beaten Black and Blue: Being a Black Cop in an America Under Siege by Brandon Tatum, published by Bombardier Books (2021).

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Mixed-race cop on policing in 2021: Ive been called racist and a Nazi - New York Post

The Luftwaffe: The Making & Breaking Of The Nazi Air Force – BBC History Magazine

Spearheaded by its forceful commander-in-chief, Hermann Gring, the Luftwaffes rise to notoriety under the Nazis appeared to corroborate their claim that Gring had built the air force als einzelner Mann (as a lone man). But in reality, the Luftwaffe had been created long before pilots such as Steinhoff took to the skies, initially as a secret Schwarze Luftwaffe (Shadow Luftwaffe) by the preceding Weimar Republic. As Heinrich Brning, chancellor of Germany between 1930 and 1932, later claimed, Hitler didnt start the Luftwaffe we did.

A likely staged shot of a German two-seater Rumpler engaging in combat with British aircraft during the First World War. (Photo by Roger Viollet via Getty Images)

To separate historical fact from myth, then, it is necessary to examine how the opportunistic Nazi regime made the air force its own both to the eventual detriment of the world and, ultimately, to itself.

Germany first began to recognise the potential of aerial warfare during the 19th century. After Prussian forces witnessed Frances use of observational and evacuation balloons during the Franco-Prussian War (187071), the newly unified German empire formed its own stationary observational balloon units. Before long, balloons were being adapted so that they could scout across long distances, transport vital equipment and drop bombs on enemy territory.

By the 1910s, military aircraft had been incorporated into the Deutsches Heer (Imperial German Army), and in 1914, Die Fliegertruppen des deutschen Kaiserreiches (the Imperial German Army Air Service) entered the First World War. Later reshaped into the Deutsche Luftstreitkrfte (German Air Force) in October 1916, it provided the army with both aerial reconnaissance and ground and air support.

Despite the strain and dangers of the dogfights, pilots often came away with more favourable memories of warfare than troops stuck in the trenches, and the image of the valiant German airman became embedded in the national psyche. Indeed, in his interwar biography of the Bavarian fighter ace Max Ritter von Mller, Hans Haller enthusiastically wrote of how there was again man and courage; there was hunting and the landing of blows. It was this chivalric aura that would soon give rise to other hallowed fighter aces such as Manfred von Richthofen (the famous Red Baron), as well as the likes of Oswald Boelcke, Max Immelmann and Werner Voss.

Manfred von Richthofen (right) talks with fellow flying officers. Before his death in combat in 1918, the Red Baron had chalked up at least 80 aerial victories. (Photo by Hulton Archive/Getty Images)

Nevertheless, with the influx of American airpower towards the end of the First World War, the odds simply became insurmountable for the Luftstreitkrfte. After Germanys defeat in November 1918, the subsequent Treaty of Versailles banned the nation from possessing any military or naval air forces, evoking, in the words of one author, a cry of rage through German aviation circles.

Included among such circles was Hermann Gring the unlikely last commander of Richthofens Flying Circus fighter wing who declared in his diary that he wanted to restore German aviation to the world.

Cloaked with all the swagger and star power of a fighter ace, he piqued the attention of an Austrian corporal with similar aspirations of restoring Germanys prewar greatness: Adolf Hitler. The two Nazis were eventually inserted into Germanys government in 1933. In January, Hitler was made chancellor, and the next month, Gring was appointed Reich commissioner of aviation.

Yet according to the former Luftwaffe anti-aircraft assistant Georg Cordts, it was only in March 1933 that Gring truly came to realise the extent of the treasures that had fallen into his lap.

Hitler, Hermann Gring and other Nazi officials pay their respects at a First World War memorial event, 1933. (Photo by Gamma-Keystone via Getty Images)

Secretly established the previous summer by the former Reich minister of defence, Kurt von Schleicher, Germanys so-called Shadow Luftwaffe was intended to boast 630 officers and 4,000 other ranks by the end of 1936. This, in turn, built upon foundations that had been laid a decade earlier, when a covert military flight school was set up in the Russian city of Lipetsk. The convenient arrangement not only allowed the Soviets to obtain vital German expertise in fighter tactics and aeronautical development, but also enabled the Germans to circumvent Versailles restrictions on military flight in Germany.

Between 1926 and 1933, around 120 German fighter pilots and 450 flying personnel attended the institution, where they used high explosives, engaged in live-fire practice and undertook mock dive bombing and fighter-bomber operations. Progress in boosting the number of potential pilots who could serve in the Luftwaffe had also been made by the Reich Transport Ministry, whose earlier recruitment efforts had seen the number of student commercial and civil pilots being trained double between December 1924 and March 1926.

Keen to capitalise on the gains made by their predecessors, the Nazi regime urgently accelerated the Luftwaffes rearmament, pledging around 10.5 billion Reichsmarks for the purpose in 1934. And, with the passing of the Wehrgesetz (Defence Law) on 21 May 1935, the Luftwaffe was officially established as a branch of the German Wehrmacht (armed forces) alongside the Heer (army) and Kriegsmarine (navy) all in direct contravention of the terms that had been set out at Versailles.

The Nazi Luftwaffe prided itself on its high operational standards, with only 5 per cent of applicants passing the rigorous entrance exam required to reach the interview stage for non-commissioned officer and officer ranks. Although the Jagdflieger (fighter pilots) and Kampfflieger (bomber crews) are two of the most well- known branches of the Luftwaffe today, by July 1944 there were 70 different career pathways within the air force, with the Nazis quick to praise the flyers who dont fly at every opportunity.

Those serving as aircraft engineers, mechanics, electricians, metal workers, carpenters and painters were all seen as being of particular value, as in the words of the propagandists a fast, reliable and smoothly functioning ground service is the prerequisite for the operational readiness and fighting power of the weapon in the air.

In terms of military strategy, the Nazis initially believed the Luftwaffe should be a Risiko or risk Luftwaffe, using its fearsome persona as a deterrent to fulfil Nazi ambitions of quickly seizing territory without provoking war. Although some airpower theorists favoured the installation of a heavy strategic bombing element within the air force, the Luftwaffes successful intervention during the Spanish Civil War (193639) from pulling off logistical triumphs for Francos Nationalists, to flushing out Republican strongholds had been a temporary distraction from adopting a heavyweight approach.But these early achievements shrouded many of the Luftwaffes shortcomings. By 1939, a shortage of manpower hovered over German aircraft production, and the Luftwaffe lacked a sophisticated ground-to- air communications system and integrated radar network. With Gring boasting that no enemy bomber can reach the Ruhr! (referring to the heavily industrialised region of western Germany), fervent Nazi rhetoric was also instilling a complacency within the Luftwaffe that would leave the Reich woefully underprotected.

When news broke that Germany had advanced into Poland on 1 September 1939, an airfield construction manager near Hamburg noted that both the youngest officers of the airborne units and old medal-decorated First World War officers sat around me with serious faces. As Hitlers bloodlust swelled, and as Grings eagerness to unleash the Fhrers Hammer increased, the Luftwaffe quickly found itself embroiled in conflicts across the globe.The Luftwaffe was intrinsic to the early success of the tactical phenomenon of blitzkrieg (lightning war), which was wielded to great effect in 1939 across Poland, before hitting Norway, Denmark, the Low Countries and France the following spring. Combining swift manoeuvres from highly mobilised armoured divisions with disorientating Luftwaffe air support, blitzkrieg was essential for the quick war Hitler desired and required. By June 1940, as the Allied forces retreated from Dunkirk, the Luftwaffe stood in awe at its accomplishments. I am proud today that I was able to take part in the greatest battle the world has ever seen, wrote a breathless Luftwaffe anti-aircraft gunner.

Hermann Gring with Adolf Hitler in 1944. Their blunders helped hasten the Luftwaffes disintegration, argues Victoria Taylor.(Photo by ullstein bild/ullstein bild via Getty Images)

Filled with confidence, the Nazi leadership turned its attentions across the Channel to Britain, but Winston Churchill had no intention of accepting Hitlers request to sue for peace. Dismayed at his refusal to surrender, the fhrer ordered the Wehrmacht to prepare for an amphibious invasion of Britain code-named Operation Sea Lion on 16 July. The Luftwaffes fighter pilots and bomber crews sought to soften up the country for invasion with a relentless aerial campaign.

Although the Luftwaffe ran the RAF ragged during the resultant Battle of Britain attacking Allied shipping, British ports, airfields, radar installations and aircraft factories it did not achieve the level of air superiority necessary to make Operation Sea Lion viable. Nor was Britains defeat secured by the Luftwaffes switch to bombing its cities during the Blitz from early September 1940 until May 1941.

Disappointed, Hitler diverted his attention towards the Luftwaffes other deployments. In particular, the air force was becoming more committed to the North African campaign fighting over Libya, Egypt, Morocco and Tunisia. The Luftwaffe also enjoyed a stunning yet demanding performance over the Balkans from April 1941, after its fellow Axis power, Italy, had invaded Greece the previous October.

Hitlers chief priority, though, was to capture more Lebensraum or living space by invading the Soviet Union. The Luftwaffe was partially redirected from the Blitz over Britain to the eastern front for Operation Barbarossa in June 1941. However, the ensuing invasion proved a step too far, and the Wehrmacht became locked in a bloody struggle with the Soviets that drained German resources even further over-stretching the heavily deployed Luftwaffe.

Matters were made even worse for the Nazis when the Allied strategic bombing offensive started to cause chaos back at home in Germany. In January 1943, Churchill and US president Franklin D Roosevelt had promised Soviet leader Josef Stalin they would ramp up their existing bombing campaigns to further split their foe into an exhausting war on two fronts.

Although the Luftwaffe still managed to inflict heavy losses upon the Allies on occasion, the ruthless British-American firestorm that rained down on Hamburg in July 1943, and the controversial raids on Dresden between 1315 February 1945, left German airmen feeling especially deflated. The three consecutive attacks in 12 hours left every aid organisation smashed and resulted in destruction unlike anything else, said one member of the Luftwaffe after visiting Dresden on 18 February 1945. [The city] is no more.

Local residents in Dresden queue for a streetcar in 1945, surrounded by the rubble from Allied bombing raids. (Image by Getty Images)

But in truth, morale had been cracking since 1944. Temperamental and experimental aircraft such as the rocket-powered Messerschmitt Me 163 Komet, the Heinkel He 162 Volksjger and the Arado Ar 234 were hastily constructed to little effect. Frustrated by Germanys decline, Hubert Retz, a Luftwaffe radio operator, declared in a letter to his fiance in May 1944 that it will soon be time for this circus to come to an end, otherwise there will be no city in the whole of Germany that has not been destroyed.

Overall, the Luftwaffes disintegration was hastened owing to a catalogue of blunders by both its operational leadership and political guardians. Its overcommitment at the hands of the rapacious Nazis strained the air force until fuel shortages, a slump in aircraft production, insufficient pilot training and inadequate logistical support all crippled the Luftwaffe from within.

Such was the desperation in the Third Reich that, towards the end of the war, the Nazi regime even suggested the formation of a dedicated Hitlerjugend (Hitler Youth) squadron to the utter horror of the Luftwaffe. Before this madcap scheme could be executed, however, the Nazis capitulated on 7 May 1945, and German aviation was set right back where it had been in 1918: defeated, disarmed, and effectively deceased.

A scathing Luftwaffe report from January 1945 perhaps captured the true reasons for the air forces undoing when it claimed that the Nazi regime had attached too little value to education and wanted too much to do with morality and the representation of dogmas [than] to be achieving the goal of a higher performance.

The Luftwaffe had been crushed under the leadership that had once helped it to fly and the price for its wartime glory would be peacetime infamy.

From jet fighters to dive bombers, these aircraft helped heighten the Luftwaffes fearsome reputation in the skies

Fitted with a liquid-cooled 1,020hp Daimler-Benz DB 601A engine, theBf 109s guts were stuffed with all the modernised apparatus of the best fighter aircraft in the mid-1930s: a retractable undercarriage, trailing edge flaps, and an enclosed cockpit. It packed a concentrated punch of ammunition, armed with various combinations of 7.9mm MG 17 machine guns and 20mm MG FF auto- cannons, though MG 151 autocannons were later experimented with.

The Bf 109E took the fight to the RAFs Hawker Hurricanes and Supermarine Spitfires in the Battle of Britain. Unlike its British counterparts, whose Rolls Royce Merlin engines float chambers were prone to flooding with fuel under negative G, the Bf 109s fuel-injected engine reduced its chances of stalling and kept it in the fight for longer.

The arrival of the Focke Wulf Fw 190 in 1941 caused huge concern for the RAFs Fighter Command, who were puzzled by the sudden appearance of this stubby-nosed aircraft. Fitted with a 1,700hp BMW 801-D2 radial engine, later variants of the Fw 190 could fly up to 440mph at 37,000ft, with a ceiling height of 39,370ft.

Although it initially struggled with a few teething problems, the Fw 190 was designed with simplicity in mind: its parts were easy to manufacture and replace. It was often considered to be sturdier, more forgiving to less experi- enced pilots, and a better all-rounder than the Bf 109.

The worlds first operational jet fighter had its full potential curtailed by numerous delays in its development. The Luftwaffe and Adolf Hitler were notably divided over its role, with the fhrer envisioning it as a Jabo (fighter-bomb- er) instead of a fighter interceptor.

Powered by a pair of BMW-003 turbojets, each with 5.40kN thrust, from November 1941, its developers attempted to replace these with the temperamental 8.24kN Junkers Jumo- 004 engines. Botched landings were common due to the planes long nose, which could obscure the pilots visibility on the ground.

Nevertheless, its advanced aerodynamics enabled it to reach an eye-water- ing top speed of 540mph. The Me 262s ultimate success lay in catalysing the rise of the jet engine.

The two-crew Sturzkampfflugzeug (Stuka) dive bomber entered service with the Luftwaffe in 1937, poweredby a 1,400hp Jumo 211J-1 inverted-V piston engine from 1940. With a top speed of 230mph, which climbed to over 300mph in a dive, this gull-winged harbinger of death enjoyed great precision bombing success in the Spanish Civil War and during the first year of the Second World War.But its vulnerability to attack due to its light armament rendered it increasingly obsolete. It is best known for its ear-piercing shriek while in a dive pro- duced by the wind whistling through the Jerichos Trumpet siren fixed under its wings which was designed to inflict psychological terror on the enemy.

The mainstay of Germanys bomber offensive in the Second World War, the Heinkel He 111 medium bomber was powered by 1,200hp Junkers Jumo 211D 12-cylinder, inverted-V, liquid-cooled engines. This five-crew bomber had a top speed of 270mph and a maximum range of 1,280 miles. It was involved in some of the deadliest bombing raids in history from Guernica and Warsaw, to Rotterdam and Coventry.

Its age was already beginning to show at the start of the Second World War, however: it was slow, lumbering, and unable to develop significantly beyond its 1934 specifications. Never- theless, it remained sturdy and dependable faithfully serving its Luftwaffe masters across all major German fronts until the end of the Second World War.

Victoria Taylor is an aviation historian based at Hull and Sheffield Hallam universities. Her PhD research examines National Socialism in the Luftwaffe

This article first appeared in BBC History Magazines Collectors Edition, Great Battles of World War Two: War in the Air

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The Luftwaffe: The Making & Breaking Of The Nazi Air Force - BBC History Magazine

The hand-cranked calculator invented by a Nazi concentration camp prisoner – Ars Technica

Enlarge / The Curta mechanical calculator.

Getty Images

Its no bigger than a drinking glass, and it fits easily in the palm of the hand. It resembles a pepper grinderor perhaps a hand grenade.

The diminutive Curta is a striking machine, a mechanical calculator that combines the complexity of a steamship engine and the precision craftsmanship of a fine pocket watch. It first appeared in 1948, and for the next two decadesuntil it was displaced by the electronic calculatorit was the best portable calculating machine on the planet. And its story is all the more compelling in light of the extraordinary circumstances in which it was invented.

The idea of the Curta came to its Austrian-born inventor in the darkness of the Buchenwald concentration camp.

Today, we take number-crunching for granted. Our smartphones have calculator apps, and most of us have a pocket calculator somewhere in our home or office. But it wasnt always so easy. For centuries, anything more than simple addition was painfully time-consuming. The first slide rules appeared in the 17th century, not long after John Napiers invention of the logarithm, but they could only handle a couple of positions beyond the decimal place. There were also various kinds of mechanical adding machines, but most were crudely built and unsuited to scientific work. By the late 19th century, more reliable desktop calculators began to appear, but they were heavy and expensive.

The shortcomings of these machines were very much on the mind of the young Curt Herzstark, whose family was in the business of making and selling calculating machines and other office equipment. Born in 1902 in Vienna, Herzstark was running the family business by the 1930s. He traveled extensively across Austria, Hungary, and Czechoslovakia, selling mechanical calculators to banks and factories. Advertisement

Thanks to an extensive interview conducted for the Charles Babbage Institute many years later, we have Herzstarks own recollections of those busy years. He recalled that as sophisticated as his companys machines were, something was missing in the world market. He remembered meeting with architects, foremen, and customs officers who needed calculating machines that were not only accurate and reliable but also portable.

People said again and again, Yes, that is nice, but isn't there anything smaller? Herzstark recalled. Slide rules were not good enough; his customers wanted precise figures, not approximations. Simply taking existing designs and making all of the various parts smaller wouldnt do the trick; the keys and knobs would be too small to use. A radical redesign was needed.

What does this kind of machine really have to look like so that someone could use it? It cannot be a cube or a ruler; it has to be a cylinder so that it can be held in one hand, Herzstark mused. And if one can hold it in one hand, then if it is miniaturized, you could adjust it with the other hand... I started to design the ideal machine from the outside first, before I designed the insides.

Herzstark began to experiment with sliders that wrapped around a cylinder so that numbers could be entered by moving a thumb or finger. He also reasoned that there only needed to be a single calculating mechanism, so long as each input digit could access it. At the heart of the device would be a single, rotating step-drum; the drum would have two sets of teeth, one for addition and one for subtraction. A central hand crank would turn the drum, and shifting the drums position by a few millimeters was enough to switch between the adding and subtracting functions. Multiplication and division were slightly more complicated, but they still required just a few flicks of the sliders and a few turns of the crank.

By 1937, Herzstark had the essentials of the design worked out; after that, it was just a matter of machining the parts and building a prototype.

And then Hitler came to power. Advertisement

On March 12, 1938, Austria was annexed by Nazi Germany (during the event known as the Anschluss). Herzstark, the son of a Jewish father and Catholic mother, feared the worst, though for the next few years, the factory was allowed to continue to operate, so long as it produced machines and tools for the German army. But the situation quickly deteriorated. Two colleagues were arrested for listening to British radio stations, and when Herzstark was offered to testify on their behalf, he, too, was arrested.

I was accused of supporting Jews, aggravation, and having an erotic relationship with an Aryan woman... it was all fabricated, Herzstark said. He was sent to the Pankratz prison in Prague and later transferred to the Buchenwald concentration camp in central Germany.

Conditions were horrific. When they hung someone, Herzstark recalled, we had to watch until he finally died. Terrible. They hung people so they died slowly, a wretched death. Herzstark was put to work in an adjacent factory that built components for Germanys V2 rockets. Eventually, a senior German engineer took him aside.

For the first time, Herzstark began to imagine that he might survive thewar.

For the first time, Herzstark began to imagine that he might survive the war. And then and there I started to draw the Curta the way I had imagined it, he said.

Buchenwald was liberated by US troops on April 11, 1945. A few days later, Herzstark walked to the city of Weimar, some four miles away, with the plans for his calculating machine in his pocket. He found a factory that was still functioning, and before long, he had a prototype of the machine.

Soon, however, the Soviet army arrived. Herzstark retreated back to Vienna, carrying only a box containing the disassembled parts of the device. With European industry struggling in the post-war years, Herzstark was happy to find that the government of tiny Liechtenstein was interested in his machine. A company called Contina AG Mauren was set up, with Herzstark serving as technical director. The first batch of Curtas went on sale in 1948. A slightly larger model that could display more digits, the Type II Curta, appeared in 1954.

The Curta was popular with accountants, engineers, and surveyors. Rally car navigators liked it because it could be used by touch; an experienced user hardly even needed to look at the device. Peter Boyce, a retired astronomer who worked for many years at the Lowell Observatory in Arizona, used a Curta when he was a graduate student at the University of Michigan in the 1960s. He remembers it as a wonderful, precision machine, one that was especially useful outside the office. It was good to take to the telescope, where I used it instead of pencil and paper if I needed to calculate something at 2:00 am.

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The hand-cranked calculator invented by a Nazi concentration camp prisoner - Ars Technica

Sniper Elite 5 Takes The War To France, Launching In 2022 – GameSpot

Developer Rebellion Entertainment has revealed Sniper Elite 5, the next chapter in its World War 2 marksmanship series. Once again starring sniper Karl Fairburne--who's now sporting a trendy tactical turtleneck--Sniper Elite 5 moves the action from the Italian front to behind enemy lines in France circa 1944. Fairburne has been tasked with investigating and destroying Operation Kraken, a secret Nazi project that threatens to end the war before the Allies can even invade Europe.

In typical Sniper Elite style, this means that you can expect a lot of Nazi heads and various other vital organs to be gruesomely shredded, with the game regularly slowing down to provide a kill-cam view inside of every unlucky soldier that walks into Fairburne's line of sight.

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Now Playing: Sniper Elite 5 Reveal Trailer

According to Rebellion, some of the new features of Sniper Elite 5 include real-world locations from France in 1944, a new traversal system that includes ziplines and shimmying along edges, and new multiplayer options. You'll be able to play the game in co-op with a friend, which allows a team to share ammo and items, give orders, and heal each other. On a more adversarial note, you can invade another players campaign as an Axis sniper for a game of cat and mouse.

Competitive multiplayer returns, with Sniper Elite 5 featuring 16-player battles and a Survival mode that sees just how long you and three other players can survive against endless hordes of Nazi troopers. Think Doom Eternal's Horde mode, to get an idea of what to expect.

Sniper Elite 5 will release on PC, PS5, PS4, Xbox One, Xbox Series X|S, and PC, and will also be available through Xbox Game Pass on day one.

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Sniper Elite 5 Takes The War To France, Launching In 2022 - GameSpot

Covid LIVE updates as Omicron now 20% of infections in England and hundreds queue for booster jabs – Manchester Evening News

The Omicron variant now represents more than 20% of Covid cases in England, Sajid Javid announced today.

The Health Secretary said the UK Health Security Agency believes the number of daily infections is around 200,000.

It comes as huge queues have formed outside walk-in centres in Greater Manchester today.

READ MORE: Latest Coronavirus infection rates as eight Greater Manchester boroughs see a rise

Meanwhile, a Tory MP has today compared Covid passports to "Nazi Germany".

Marcus Fysh, MP for Yeovil, Somerset, told the BBC he will be voting against vaccine passports on Wednesday.

Last night Boris Johnson said all adults will get Covid boosters by the end of the month.

The one million jabs a day target is designed to tackle the Omicron 'tidal wave' sweeping the UK.

Meanwhile, the Prime Minister this morning confirmed the first death from the Omicron variant in the UK.

Mr Johnson said at least one patient has died from the Covid strain sweeping the country.

It comes as the scandal-hit PM will be investigated over claims he broke Covid laws by hosting a Downing Street quiz.

The Sunday Mirror revealed Mr Johnson chaired a virtual quiz with two colleagues by his side.

Cabinet Secretary Simon Case has widened a probe into parties last year in Westminster, while London was in lockdown.

Sajid Javid has warned some non-urgent GP appointments and surgical procedures will be delayed until the New Year.

Meanwhile, the Health Secretary refused to rule out schools being closed next month and said 10 people are in hospital with Omicron.

Coronavirus lateral flow tests have run out and the NHS booster jab booking site has crashed.

Work from home guidance is back today, as more Plan B guidance is implemented to curb the spread of Omicron.

Mr Johnson said yesterday that the country should expect a 'tidal wave' of cases, as the UKs Covid alert level was raised from three to four.

As well as work from home guidance, rules on face masks have already been tightened and Covid passes will be required to get into nightclubs and other large venues from Wednesday.

In a short speech, he said: Today we are launching the Omicron Emergency Boost, a national mission unlike anything we have done before in the vaccination programme to Get Boosted Now.

A fortnight ago I said we would offer every eligible adult a booster by the end of January.

Today, in light of this Omicron Emergency, I am bringing that target forward by a whole month.

Everyone eligible aged 18 and over in England will have the chance to get their booster before the New Year.

We have spoken today to the Devolved Administrations, to confirm the UK Government will provide additional support to accelerate vaccinations in Scotland, Wales and Northern Ireland.

Fears have been raised, however, that the booster rollout will place an unprecedented level of pressure on the NHS at the system's most difficult time of year.

Greater Manchester's medics have voiced concerns in the wake of Prime Minster Boris Johnson's address, with one GP telling theManchester Evening News his practice will be forced to 'cancel routine work' and 'all staff leave' until the end of December, adding the rollout will 'break general practice'.

Follow our live blog below for the latest coronavirus updates throughout the day.

Sign up to the MEN email newsletters to get the latest on sport, news, what's on and more by following this link

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Covid LIVE updates as Omicron now 20% of infections in England and hundreds queue for booster jabs - Manchester Evening News

May you live long and be prosecuted | Efraim Zuroff | The Blogs – The Times of Israel

This past Friday, Herbert Wahler celebrated his 100th birthday. Quite an achievement for a German, who spent a significant part of World War II serving on the Eastern front in Ukraine. Yet upon closer examination of Wahlers service record, its not that surprising, since, for a significant part of the conflict, Wahler was not dodging bullets shot at him by Red Army soldiers, but rather contributing to the efforts of Einsatzgruppe C to mass murder innocent Jews and other enemies of the Reich.

Einsatzgruppe C was one of the four special killing squads, labeled A, B, C, and D, the Nazis sent in June 1941, along with the Wehrmacht troops invading the Soviet Union in Operation Barbarossa, to begin the mass murder of Jews, even before the formal decree of the Final Solution was officially adopted at the Wannsee Conference on January 20, 1942. They spread out over the entire territory, with A responsible for the former Baltic countries of Lithuania, Latvia, and Estonia; B in charge in Belarus; C active in central Ukraine and D in southern Ukraine. In the course of 1941-1943, these units, which numbered approximately 3,000 men, with assistance from members of the Wehrmacht, German police units, and local collaborators, were responsible for the mass murder by shooting of approximately 2 million persons, among them 1.3 million Jews.

Wahler served initially in a Waffen-S.S. unit, which in late July 1941 was assigned to Einsatzgruppen C. The unit went from place to place murdering tens of thousands of innocent civilians, most of whom were Jewish, and by the end of October 1941 had killed an estimated 78,000 people, and carried out the largest mass murder in the history of the Holocaust, the September 29-30 massacre of 33,771 Jews in Babi Yar, a ravine on the outskirts of Kyiv.

Despite the extremely important role played by the Einsatzgruppen in the Holocaust, relatively few of those who carried out the murders were brought to justice. The Americans conducted a trial of 24 of the senior leaders of the units, and two-thirds of the defendants were sentenced to death (14) or life imprisonment (2), but only four men were executed. All the others who were convicted had their sentences reduced. (Four others were tried and executed by other countries.) Only about 100 men were subsequently indicted in West Germany, a few were convicted and given mild sentences, and none were executed.

Given those circumstances, I was expecting that in the wake of the dramatic change a decade ago in German prosecution policy vis--vis Nazi war criminals, which made it possible to convict those who served in death camps and/or camps with gas chambers or gas vans, or camps with a high mortality rate, based on service alone (as opposed to the previous requirement of proving a specific crime against a specific victim), it would now be possible to convict people who served in the Einsatzgruppen. In fact, shortly after the Demjanjuk verdict, I met in 2011 with the directors of the Central Office for the Clarification of Nazi Crimes (the federal German agency which initiates Nazi war crimes investigations) to discuss the issue, and they confirmed that indeed they had adopted that policy.

That did not happen, however, so three years later, in the fall of 2014, I checked the Weisenthal Center archives for all the names of people who served in the Einsatzgruppen, for whom we had a date of birth. We had a total of 1,293 names (out of about 2,950) of those who served in A, B, C, or D, of which we had dates of birth for 1,069. Of those, 80 people, 76 men and four women, were born in 1920 or later. On September 1, 20104, I sent that list, which included Herbert Wahlers name, to the German Justice Minister Heiko Maas and the Minister of the Interior Thomas de Maiziere. It took the German authorities 17 months to check the list, which they informed me included three people alive in Germany, all of whom had served in Einsatzgruppe C.

I received the news with a mixture of joy and trepidation. Joy that at least three were alive, trepidation that they might not live long enough to be prosecuted which is why I sometimes find myself praying for the good health of Nazis who might be prosecuted). In the meantime, my fears turned out to be well-founded and Kurt Gosdek and Wilhelm Karl Friedrich Hoffmeister have already died without being brought to justice. Although Wahler has admitted in media interviews that he was in Kyiv during the massacre, the prosecutor in Kassel closed his case, probably because Wahler claims that he was a medic, leaving unanswered the question of who it was he was assisting, the perpetrators or the victims.

So last Friday, a demonstration was held in front of Wahlers house in Meslungen by members of the Dokumentartheaters Berlin and the AK Angreifbare Traditionspflege, and members of the Liberal Jewish community in nearby Felsberg to demand that justice be served. My message to them, which was read at the demonstration, was simple:

The passage of time in no way diminishes the guilt of the murderers and their accomplices. And old age should not afford protection for merciless killers.

Herbert Wahler may think that What has been, has been, its over, as he told the ARD journalists fromKontraste, but as long as any of the men and women from the Einsatzgruppen, deaths head units, and anyone who served in the concentration camps where so many innocent human beings were murdered are alive, they cannot be allowed to live their lives in peace and tranquility. That is a privilege they denied their victims.

They must be held accountable! Even if they were not officers or did not have high ranks. In death squads and death camps, there is no such thing as a small cog. Its the small cogs, who ensured the implementation of the Final Solution, and they must be held accountable.

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May you live long and be prosecuted | Efraim Zuroff | The Blogs - The Times of Israel