The Meaning and Origin of Poggers – Twinfinite

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Breaking down Poggers!

Published on June 22, 2022 John Esposito

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Twitch has seen a massive rise in popularity over the years with gamers looking to become the next top streamer. The rise in the streaming platforms popularity has also brought the invasion of Twitch culture into the world we live in with everyone shouting and using Twitch lingo in their everyday talk track. One of the mot popular terms is poggers and, if you have no idea what it means, keep on reading as were breaking down what poggers means and the origins of the word.

Poggers is used as a term to express excitement or celebration.

For example;

I just got a new car bro.

Thats poggers.

Poggers essentially is a substitute for the word cool or a similar term to share excitement. Any way that you express cool, poggers can be substituted in its place.

For example;

I just lost my car keys.

Thats not poggers.

In Twitch chat, it often is depicted with an emote of Pepe the Frog expressing excitement or celebration. However, it has evolved beyond Pepe as streamers will create their own version of the emote.

The earliest recollection of the term was back in February 2017, when a user uploaded the emote to BetterTTV: an emote platform that can be linked to a Twitch channel for additional chat emotes. After it was uploaded to BetterTTV, it saw a huge increase in usage amongst the League of Legends community as players would use the term to describe a nice or exciting play. From there, the term took off in popularity seeing huge usage in Fortnite for the same reason.

That is everything we know about the meaning of poggers and its origin. As you look to become more versed in the universe of Twitch, be sure to check out our guides on how to create Twitch clips to make awesome memories or how to change your name on Twitch.

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The Meaning and Origin of Poggers - Twinfinite

What is a Groyper? It’s a Combination of Nick Fuentes and Pepe the Frog

Behind Nick Fuentes, the host of America First, follows a new group of far-right conservatives. They call themselves the Groypers. And theyve launched a war against the Republican party.

Charlie Kirk, the founder of Turning Point USA, and Donald Trump Jr. do not seem like likely targets for a rising right-wing faction. But much to their surprise recently, the Groyper army chose events hosted by Kirk and Trump to descend upon.

Groypers attended a Turning Point USA conference at Ohio State University to heckle speakers with loaded questions. Turning Point is a conservative nonprofit that mobilizes Republican students on college campuses.

Trump, meanwhile, was booed off the stage at a free speech event at the University of California Los Angeles. The Groypers are claiming these two events, along with seven others, as victories against the mainstream Republican party, which they now consider to be fake conservatism.

A Groyper is a member of Fuentes movement of his brand of alt-right white nationalism. The alt-right is a loose collection of conservatives that harbor white nationalists. Fuentes is currently one of its most public faces.

As their chosen mascot, Groypers took hold of an exploitable illustration of Pepe the Frog. While iterations of Pepe are commonly used within the far-right, this version is of Pepe resting a conspicuous face against his two hands.

The meme appears in different forms on Groypers Twitter pages to show their allegiance.

https://twitter.com/that_groyper/status/1203275552636973059

Fuentes Twitter bio declares himself as the Groyper leader. His image header illustrates Pepe soldiers holding up a flag that states Groyper War, Total Victory!

The header also has the names of the events, primarily on college campuses, and dates of when the Groypers heckled conservative events, all claiming victory.

The Groypers galvanize around the idea that the current Republican party is fake conservatism. Basically, they try to push each conservative position farther to the right by supporting a white, male, heterosexual America. They embrace white nationalism in support of policies that, although they have foundations in conservatism, even some Republicans find too far.

The group is extreme on immigration restrictionism, often calling for a total shutdown of immigrants into America, and pushes anti-LGTBQ propaganda to continue to fight a culture wore they believe the right gave in on.

Support of Israel is one major difference between the Groypers and what they call the traditional Conservative Inc. While the Republican party remains firm in supporting its Israeli ally, the Groypers extreme nationalism and anti-Semitism pushes them outside the bounds of normal right-wing discourse.

America is NOT a propositional nation. We have NO ALLEGIANCE to Israel, Fuentes posted on his Telegram according to Vox. We are CHRISTIANS and we dont promote degeneracy. Demographic replacement is REAL and it will be CATASTROPHIC.

Fuentes is also known for casting doubt on the number of Jews that died in the Holocaust, using crude analogies relating to cookies and baking.

https://www.youtube.com/watch?v=F9aco6o5WBE

He described the above cookie comparison as his hilarious and epic Holocaust joke on his Telegram channel.

The Groypers are loyal to Fuentes and share this anti-Semitic perspective. For example, one Groyper page posted a tweet with a photo of a blimp that says jews rape kids.

your uber driver has arrived, @ayyyetone tweeted with the photo.

Fuentes, an extremely online pundit, thinks he can shape youth conservatism because hes better at catering to the internet culture that many Gen Z or Zoomer college students are inclined to consume.

I think the generational style is so important, Fuentes posted on Telegram. Idk if its post modern or post ironic but the style and tone is very native to Zoomers which is i think why ppl like Shapiro or Kirk imagine theyre check mating me with some of these controversies but in reality its just turning young ppl onto my content.

Fuentes and the Groypers primarily target the bulk of the Republican party.

In the past, they have heckled speakers like right-wing talk show host Ben Shapiro, as well as Trump Jr. and Kirk.

Their goal is to expose high-profile Republicans by asking loaded questions, often about Israel and homosexuality, to prove their distance from the extreme or true right.

There were a number of trolls who sabotaged the Q&A portion of tonights @tpusa event, Turning Points Benny Johnson tweeted following an event at Ohio State University. Many of the questions were abhorrent and were not asked in good faith.

Fuentes responded to Johnson by calling out Turning Points moderate stance. Turning Point has been scrutinized in the past for its own racist biases.

Turning Point is now making a concerted effort to slander all critics of their bullshit fake conservatism as extremist trolls,' @NickJFuentes tweeted. We are America First and you are being exposed for the sellout frauds you are.

Fuentes has been promoting the Groypers next event on Dec. 20. White nationalists Patrick Casey and Jacob Lloyd will join Fuentes in West Palm Beach for the Groyper Leadership Summit. The Groypers will also be mobilizing against Republicans again, as the event is set to overlap with another Turning Point conference.

The GLS will feature speeches by myself, Patrick Casey, and Jacob Lloydwe invite all Groypers to join us for a celebration of our Total Victory over Charlie Kirk in the Groyper Wars! Fuentes posted on his Telegram board.

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What is a Groyper? It's a Combination of Nick Fuentes and Pepe the Frog

Vir Biotechnology (VIR) Stock: Why It Increased Over 5% Today – Pulse 2.0

The stock price of Vir Biotechnology Inc (NASDAQ: VIR) increased by over 5% during intraday trading today. Investors are responding positively to Vir Biotechnology announcing new data from its robust hepatitis B virus (HBV) clinical trial program, including results from an ongoing Phase 2 clinical trial of VIR-2218, results from an ongoing Phase 1 clinical trial of VIR-3434 and preclinical data evaluating both investigational compounds as monotherapy and in combination. And the data was presented in one oral and two poster presentations at the International Liver Congress (ILC) 2022, the Annual Meeting of the European Association for the Study of the Liver (EASL).

In summary, the data presented at ILC demonstrated that a six-dose regimen of VIR-2218 provided greater and more durable reductions in hepatitis B surface antigen (HBsAg) than a two-dose regimen, with all participants achieving a >1 log10 IU/mL reduction during the trial. Phase 1 results evaluating VIR-3434 showed that a single dose (6 mg, 18 mg, 75 mg or 300 mg) resulted in a rapid reduction of HBsAg, with the largest and most durable response noted with the 300 mg dose. Finally, preclinical in vivo data demonstrated that the combination of both investigational compounds resulted in greater HBsAg reductions than either compound alone.

As part of its ongoing efforts to advance its broad HBV portfolio, Vir is expecting to dose the first patient in Part B of the Phase 2 MARCH (Monoclonal Antibody siRNA Combination against Hepatitis B) trial evaluating VIR-2218 in combination with VIR-3434 for 24 and 48 weeks, and in combination with interferon, by the end of June. And previously reported results from Part A demonstrated that VIR-3434 combined with VIR-2218 provided an additional 2 log decline in HBsAg loss over the 3 log decrease with VIR-2218 alone. No drug-related safety signals were observed. The additional data from Part A are expected later this year. However, with clinical trial sites in Ukraine and Moldova, the Company is continuing to monitor the war in Ukraine for any potential impact on timing.

The additional milestones expected in the second half of 2022 include:

Additional data from the Phase 2 trial of VIR-2218 in combination with PEG-IFN-.

Initial data from the Phase 2 trial led by Brii Biosciences evaluating VIR-2218 in combination with BRII-179, an investigational T cell vaccine, for the potential treatment of chronic HBV infection.

The initiation of a Phase 2 platform trial of VIR-2218 in combination with VIR-3434 in viremic patients (THRIVE/STRIVE sub-protocols), with initial data expected in the second half of 2023.

The initiation of a Phase 2 trial of VIR-2218 in combination with VIR-3434 for the treatment of chronic hepatitis D virus (HDV) infection, with initial data expected in 2023.

The company also expects to report initial data from the Phase 2 trial evaluating various combinations of VIR-2218, selgantolimod (GS-9688), Gilead Sciences investigational TLR-8 agonist, and nivolumab, an approved PD-1 inhibitor, as a potential cure regimen for chronic HBV infection in the first half of 2023.

KEY QUOTE:

The data presented at the International Liver Congress 2022 continue to indicate that our therapeutic strategy of combining an antiviral with an immunomodulator to restore immunologic control in patients with chronic HBV is additive and offers the potential for a functional cure. As we continue to evaluate VIR-2218 and VIR-3434, we are encouraged by the potential of these two investigational medicines alone and in combination. These data, alongside the anticipated initiation of Part B of the MARCH trial by the end of June, are important milestones in our broad HBV portfolio for which we expect multiple data readouts throughout 2022 and 2023.

Carey Hwang, M.D., Ph.D., Virs senior vice president, clinical research, head of chronic infection

Disclaimer: This content is intended for informational purposes. Before making any investment, you should do your own analysis.

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Vir Biotechnology (VIR) Stock: Why It Increased Over 5% Today - Pulse 2.0

The Termeer Foundation Selects Inaugural Termeer Scholars: CRISPR Pioneers and Biotechnology Innovators Omar Abudayyeh and Jonathan Gootenberg of MIT…

BOSTON--(BUSINESS WIRE)--The Termeer Foundation, a nonprofit organization focused on connecting life science innovators and catalyzing the creation of new medicines, today announced the inaugural recipients of the 2022 Termeer Scholars Awards. These prestigious new awards support emerging biomedical researchers developing scientific advances like new medicines and diagnostics that represent the future of the biotechnology industry and the potential to positively impact patients lives.

This years co-recipients of the Termeer Scholars Award are Omar Abudayyeh and Jonathan Gootenberg, McGovern Institute Fellows at the Massachusetts Institute of Technology (MIT) whose lab is leveraging natural biological systems, including CRISPR biology, to develop a suite of tools for next-generation cellular engineering. These tools have been adopted by researchers over the world and formed the basis for four companies that Omar and Jonathan have co-founded. They will receive a $50,000 grant to support professional development, knowledge advancement and/or stakeholder engagement and will become part of The Termeer Foundations signature Network of Termeer Fellows (first-time CEOs and entrepreneurs) and Mentors (experienced industry leaders).

The Termeer Foundation is working to improve the long odds of biotechnology by identifying and supporting future biotech leaders; if we help them succeed as leaders, we can help their innovations reach patients. While our Termeer Fellows program has supported first time CEOs and entrepreneurs for the past five years, our new Termeer Scholars program will provide much needed support to the researchers whose innovative ideas represent the future of the biotechnology industry - researchers like Omar and Jonathan, said Alan Walts, Co-Founder and Member of the Board of Directors for The Termeer Foundation.

The Abudayyeh-Gootenberg lab at MIT is developing a suite of new tools to enable next-generation cellular engineering, with uses in basic research, therapeutics and diagnostics. Building off the revolutionary biology of natural biological systems, including mobile genetic elements and CRISPR systems, the team develops new approaches for understanding and manipulating genomes, transcriptomes and cellular fate. The technologies have broad applications, including in oncology, aging and genetic disease.

Omar Abudayyeh is a McGovern Institute Fellow at MIT. He was part of the Harvard-MIT Health Sciences and Technology program as an MD/PhD student and completed his doctoral work in Feng Zhangs lab at the Broad Institute, where his research centered on novel CRISPR enzymes for applications in genome editing, therapeutics, and diagnostics. Dr. Abudayyeh was recognized as a Technology Review TR35 Innovator, Endpoints 20 under 40 awardee, 2018 Forbes 30 under 30 in Science and Health Care, and Business Insider 30 under 30.

Jonathan Gootenberg is a McGovern Institute Fellow at MIT and received his PhD in Systems Biology from Harvard University, during which he conducted research with Aviv Regev and Feng Zhang at the McGovern Institute and Broad Institute. During his PhD, Gootenberg focused on the development of molecular technologies for treating and sensing disease states, crossing disciplines by utilizing novel computational techniques, microbiology, biochemistry, and molecular biology to uncover new CRISPR tools, including Cas12 and Cas13. He and his co-authors developed Cas13 into a toolbox with uses in fundamental research, therapeutics, and diagnostics. He has received multiple awards, including the Technology Review TR35, Forbes 30 Under 30, Endpoints 20 Under 40, and Business Insider 30 and Under.

"The Termeer Foundation is committed to championing emerging biotechnology leaders and finding people who want to solve the biggest problems in human health, said Belinda Termeer, President of The Termeer Foundation. "By supporting researchers like Omar and Jonathan, we plant the seeds for future success in individuals who are preparing to make significant contributions in academia and industry.

Abudayyeh and Gootenberg were honored at the Termeer Foundations annual dinner in Boston on June 16, 2022. The event also recognized the 2022 class of Termeer Fellows.

About The Termeer Foundation

Building on the bold legacy of Henri Termeer, who pioneered groundbreaking treatments for rare diseases, The Termeer Foundation connects life science innovators and catalyzes the creation of new medicines. The Foundations network of emerging and established healthcare innovators cultivates tomorrows leaders and leverages their collective expertise to solve complex problems in drug development and accessibility. The Foundation also integrates its network with academic institutions, nonprofits, regulatory agencies and other organizations across the global healthcare ecosystem to provide expert counsel, stimulate innovation, eliminate barriers to progress, and ultimately connect the world of healthcare until every patient has a cure. Visit us at http://www.termeerfoundation.org or on LinkedIn @TermeerFoundation.

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The Termeer Foundation Selects Inaugural Termeer Scholars: CRISPR Pioneers and Biotechnology Innovators Omar Abudayyeh and Jonathan Gootenberg of MIT...

Biotechnology Algae Cultivation Process (Micro Algae) Market Size And Forecast to 2028 |Cellana, Ecoduna, Algenol Biofuels, Solix Biofuels, Sapphire…

The Biotechnology Algae Cultivation Process (Micro Algae) Market researchexamines market estimates and predictions innicedetail. Itadditionallyaidswithin theexecutionof thosefindings by demonstrating tangiblebenefitsto business stakeholders andbusinessleaders.eachcompanyshouldanticipatehowevertheir productare going to beutilized inthe longer term. Giventhislevel of uncertainty caused by the COVID-19state of affairs, thisanalysisisessentialforhigherunderstanding previous disruptions and increasing readiness forsuccessivesteps in decision-making.the foremostrecent studymakes an attempttoaltertheadvancedmarketplace forcompanyexecutives by providing strategic insights and exhibiting resiliency insuddenconditions. The insightswillassist all potential readers indistinguishingnecessarybusinessbottlenecks.

The primary objective of the report is to educate business owners and assist them in making an astute investment in the market. The study highlights regional and sub-regional insights with corresponding factual and statistical analysis. The report includes first-hand, the latest data, which is obtained from the company website, annual reports, industry-recommended journals, and paid resources. The Biotechnology Algae Cultivation Process (Micro Algae) report will facilitate business owners to comprehend the current trend of the market and make profitable decisions.

Market Leaders Profiled:

Report Analysis & Segments:

The Biotechnology Algae Cultivation Process (Micro Algae) is segmented as per the type of product, application, and geography. All of the segments of the Biotechnology Algae Cultivation Process (Micro Algae) are carefully analyzed based on their market share, CAGR, value and volume growth, and other important factors. We have also provided Porters Five Forces and PESTLE analysis for a deeper study of the Biotechnology Algae Cultivation Process (Micro Algae).The report also constitutes recent development undertaken by key players in the market which includes new product launches, partnerships, mergers, acquisitions, and other latest developments.

Based on Product Type Biotechnology Algae Cultivation Process (Micro Algae) is segmented into

Based on the Application Biotechnology Algae Cultivation Process (Micro Algae) is segmented into

The report provides insights on the following pointers:

1 Market Penetration: Comprehensive information on the product portfolios of the top players in the Biotechnology Algae Cultivation Process (Micro Algae).

2 Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

3 Competitive Assessment: In-depth assessment of the market strategies, and geographic and business segments of the leading players in the market.

4 Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

5 Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Biotechnology Algae Cultivation Process (Micro Algae).

Schedule a Consultation Call With Our Analysts / Industry Experts to Find a Solution For Your Business @ https://www.marketresearchintellect.com/ask-for-discount/?rid=375531

Various Analyses Covered:

Regional assessment of the Biotechnology Algae Cultivation Process (Micro Algae) has been carried out over six key regions which include North America, Asia-pacific, Europe, Latin America, Middle East, and Africa. Moreover, the report also delivers deep insights on the ongoing research & development activities, revenue, innovative services, the actual status of demand and supply, and pricing strategy. In addition to this, this report also delivers details on consumption figures, export/import supply, and gross margin by region. In short, this report provides a valuable source of guidance and clear direction for the marketer and the part interested in the market.

North America(United States, Canada)Asia Pacific(China, Japan, India, South Korea, Australia, Indonesia, Others)Europe(Germany, France, United Kingdom, Italy, Spain, Russia, Others)Latin America(Brazil, Mexico, Others) The Middle East and Africa

Frequently Asked Questions:

About Us:Market Research Intellect

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

Contact Us:Mr. Steven FernandesMarket Research IntellectNew Jersey (USA)Tel: +1-650-781-4080

Email:sales@marketresearchintellect.com

Website: https://www.marketresearchintellect.com/

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Biotechnology Algae Cultivation Process (Micro Algae) Market Size And Forecast to 2028 |Cellana, Ecoduna, Algenol Biofuels, Solix Biofuels, Sapphire...

BRIM Biotechnology enters OTC trading in Taiwan – Bio-IT World

Taipei, Taiwan, 23rdJune 2022 /SciadNewswire/BRIM Biotechnology, Inc.(BRIM, TWSE 6995) enters OTC trading in Taiwan on 23rdJune 2022, CST. The news was announced at the companys first earnings call on 22ndJune 2022.

Established in July 2013, BRIM is a clinical-stage company developing novel regenerative therapies to help combat and cure ophthalmology and degenerative joint diseases. BRIM applies world-leading expertise in translational science to accelerate the development of early research technology platforms to clinical drug candidates. BRIM is led by Chairwoman and CEO Dr. Haishan Jang, and the companys current paid-in capital is approximately 23 million USD.

BRIM has several novel drug products in its pipeline, all underpinned by the companys proprietary stem cell regenerative Pigment Epithelium-Derived Factor (PEDF) derived Short Peptide (PDSP) technology platform.

BRIMs lead candidate BRM421 has the potential to be a first-in-class peptide treatment for Dry Eye Syndrome (DES). Phase II/III clinical trials completed in the U.S. demonstrate that the drug has the potential to speed up the repair of corneal damage through stimulation of corneal stem cell proliferation and differentiation, as well as to treat disease symptoms. Data demonstrate that BRM421 is safe and well-tolerated with a unique early onset curative effect1.

In only seven years, BRIM has progressed BRM421 from pre-clinical to late-stage clinical trials and has successfully licensed the commercial rights in greater China (China, Hong Kong, and Macau) to Grand Pharma (China) Co., Ltd (HK00512). The rapid development and significant licensing deals reflect the unique advantage of the PDSP technology platform and BRIMs expertise.

Dr. Jang commented, Our goal is restoration and repair of the damage caused by DES. The PDSP technology platform underpinning BRM421 and other assets in our pipeline could revolutionize the ophthalmology and degenerative joint disease fields. If successful, BRM421 could treat millions of people around the world living with DES and provide an excellent example of a first-in-class new drug developed in Asia. OTC trading brings us one step closer to achieving our vision to bring sustainable and affordable healthcare innovation to the world.

DES is a common yet complex chronic disease. According to Global Data (2020)2, the DES market size in 2018 was approximately 3.9 billion USD across nine markets (US, France, Germany, Italy, Spain, UK, Japan, China, and India). This market is expected to grow in scale and size due to heavy screen-time usage, greater use of contact lenses and increasing numbers of eye surgeries3. Global Data predicts that the DES market size will reach approximately 11 billion USD in 20282. Research also suggests that COVID-19 increases the risk of developing DES4.

Currently, treatment options for DES are very limited and most treat the symptoms rather than the disease. Existing treatments include anti-inflammatories or artificial tears and lubricants, none of which repair the damage caused by DES.

Peptides shorter than 40 amino acids, such as BRM421, are categorized as small molecules, meaning they follow the New Drug Application (NDA) regulatory pathway rather than the Biologics License Application (BLA) pathway. This significantly reduces development time and costs, making novel peptides an attractive new treatment option for many pharmaceutical companies.

Beyond BRM421, BRIMs PDSP technology platform can be applied across multiple therapy areas and indications. Early research indicates that the PDSP technology platform demonstrates efficacy in corneal wound healing, diabetic ulcer wound healing, osteoarthritis, androgenic alopecia, and muscle/tendon regeneration. BRIM has a rapidly expanding pipeline which includes treatments for severe corneal damage (BRM423), and osteoarthritis (BRM521).

With this next step of OTC trading, we are excited to progress development at an accelerated pace and will continue our journey in ophthalmology to bring the first regenerative peptide therapy for DES to the market in the near future, as well as apply our learnings to a wide range of other diseases with significantly unmet needs, said Dr. Jang.

BRIM Biotechnology, Inc.Shih-Ya ChangT: 886 2 2659 8586 #111E:info@brimbiotech.com

Sciad CommunicationsMaria Patey / Sophie ProtheroeT: 020 3405 7892E:BrimBiotech@sciad.com

About BRIM Biotechnology, Inc.

BRIM Biotechnology, Inc. is a clinical-stage company developing novel regenerative therapies in ophthalmology and degenerative joint diseases. Established in July 2013 to accelerate the development and transformation of early research technology platforms to clinical drug candidates, BRIM applies world-leading expertise in translational science to develop new treatments that help combat and cure disease. The companys virtual business model, combined with its proprietary PDSP technology platform, bridges the gap between research and clinical development faster, de-risks the process, and accelerates the progression of early-stage candidates in indications with high unmet medical needs.

For more information, please visitwww.brimbiotech.com.

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BRIM Biotechnology enters OTC trading in Taiwan - Bio-IT World

Northern Trust Appointed to Provide Asset Servicing Solutions to International Biotechnology Trust – Business Wire

LONDON--(BUSINESS WIRE)--Northern Trust (Nasdaq: NTRS) has been appointed to provide global custody, fund accounting, depositary services and its outsourced trading service Integrated Trading Solutions to International Biotechnology Trust and its investment manager SV Health Managers.

Founded in 1994, International Biotechnology Trust is a United Kingdom (UK) investment trust, that, as at end of May 2022, had a market capitalisation of over 255 million. Publicly-traded on the London Stock Exchange, its objective is to achieve long-term capital growth by investing primarily in biotechnology and other life sciences companies with the potential for high growth through the development and/or commercialisation of a product, device or enabling technology.

Laurence Everitt, head of Global Fund Services, UK at Northern Trust said: We are delighted to partner with International Biotechnology Trust and SV Health Managers in delivering the administration, execution and technology capabilities they and their investors require. Our Whole Office approach to working with investment managers allows us to deliver these solutions via a single platform and integrated service model reducing business complexity for clients while helping us meet their evolving requirements.

Northern Trusts Global Fund Services business provides services including fund administration, global custody, investment operations outsourcing and data solutions to global investment managers supporting a range of complex investment strategies across the full spectrum of asset classes.

Integrated Trading Solutions is part of Northern Trust Capital Markets, which is comprised of a number of Northern Trust entities that provide trading and execution services on behalf of institutional clients, including institutional brokerage, foreign exchange, securities lending and transition management.

About Northern Trust

Northern Trust Corporation (Nasdaq: NTRS) is a leading provider of wealth management, asset servicing, asset management and banking to corporations, institutions, affluent families and individuals. Founded in Chicago in 1889, Northern Trust has a global presence with offices in 22 U.S. states and Washington, D.C., and across 23 locations in Canada, Europe, the Middle East and the Asia-Pacific region. As of March 31, 2022, Northern Trust had assets under custody/administration of US$15.5 trillion, and assets under management of US$1.5 trillion. For more than 130 years, Northern Trust has earned distinction as an industry leader for exceptional service, financial expertise, integrity and innovation. Please visit our website or follow us on Twitter.

Northern Trust Corporation, Head Office: 50 South La Salle Street, Chicago, Illinois 60603 U.S.A., incorporated with limited liability in the U.S. Please read our global and regulatory information.

http://www.northerntrust.com

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Northern Trust Appointed to Provide Asset Servicing Solutions to International Biotechnology Trust - Business Wire

Biotechnology Act to Crash Cost of Vaccines, Drugs Import, Drive Research THISDAYLIVE – THISDAY Newspapers

With the passage of the Biotechnology Act by the National Assembly and its assent by President Muhammadu Buhari, the Chief Executive Officer of Biotechnology Development Agency, Prof. Abdullahi Mustapha, opined that it will crash the high cost of vaccine and medicine importation into the country.Chiamaka Ozulumba reports

The Chief Executive Officer (CEO), National Biotechnology Development Agency (NABDA), Prof. Abdullahi Mustapha, has said the passage of the Biotechnology Act by members of the National Assembly and assented by President Muhammadu Buhari will crash the high cost of vaccine and medicine importation into the country.

The good thing about the passage of the Act, he acknowledged, is that the era of importation of substandard drugs is surely coming to an end because local production of medicinal and vaccines products will lead to quality enhancement.On the free fall of the naira, the NABDA boss, expressed optimism that when pharmaceutical companies start local manufacturing of drugs, the strength of the naira will regain its value.

Mustapha, expressed excitement that the agency is hitting the ground running on deployment of research activities, adding that the Act will fuel research as it indexes Nigerias readiness to harness cutting-edge technologies for sustainable development, particularly, those that guarantee better life for all Nigerians.

On food security, Mustapha, said the law which confers legal authority on the agency to conduct research in biotechnology will drive Nigerias food security, industry, job creation and environment for national development.

He commended the lawmakers for the passage of the Act in April even as he added that they have demonstrated sound understanding of the dynamics of development in a globalised knowledge economy, specifically using biotechnology.

Briefing the media on the significance of the law at NABDA Headquarters in Abuja over the weekend, Mustapha, said the agency now has a legal framework that guides and guards its researches, aimed at boosting agricultural produce, promoting environmental sustainability, development of vaccines and drugs.

According to him, no nation can insulate science from its development agenda and thrive. This is particularly true, if the nation seeks to replicate the amazing development miracle of the Asian Tigers, he added.

As a developing nation with a low-income economy, he said Nigeria must conduct research to accelerate national development, lower Nigerias debt burden, and extricate it from the poverty trap.

Biotechnology, the NABDA boss added, is an accelerator of inclusive national growth that provides a knowledge-based approach to solving public challenges, and ensuring future sustainability, as witnessed in the height of COVID-19 Pandemic, where biotechnology provided a quick and safe solution.

With this development, we are optimistic that the agency will be able to consolidate Nigerias leadership in Africas biotechnology space, and launch the nation into the stratosphere of global economic players.

The Act makes NABDA; a body corporate with perpetual succession and a common seal. It is heartening to note that this development has moved NABDA from the realm of a promotional agency to that of a research institution.

It has strategically poised NABDA to pursue its mandate of driving national development by ethically harnessing applications of biotechnology. Some of these applications which are vital to Nigerias development are:

First, green biotechnology, which encompasses the agricultural field; second, red biotechnology, which relates to the medical field; third, blue biotechnology, which consists of the aquatic field; fourth, white biotechnology, which is about the industrial domain.

In addition, the Act will enable the agency draw up programmes and policies for biotechnology utilisation in Nigeria as well as create an avenue to publish and disseminate research findings and recommendations of the agency on biotechnology.

The passage of the Act will be a catalyst for the stimulation of rapid commercialisation of Biotechnology Research and Development products.

It will afford the agency a platform to collaborate with International Research Centres, NGOs, national and international biotechnology agencies and institutions, and ensure a sustainable mechanism for adequate funding of biotechnology activities through national and international funding agencies.

On Public Private Partnership (PPP), he said the Act recognises the imperative of the collaboration for groundswell private-sector participation in biotechnology enterprises, stressing that it stipulates that NABDA should coordinate and conduct strong advocacy programmes, seminars, conferences and workshops to foster multi-stakeholders cooperation for inclusive national development.

I am optimistic that private sector participation in biotechnology will extend the frontiers of economic development, and thereby, abate Nigerias over reliance on petrodollar. he said.

Mustapha, said private sector participation is needed for the mass production, commercialisation, and supply to end-users of the Bio-digesters invented by the agency, adding: As you are aware, the biodigesters which were locally fabricated with locally sourced material, would foster energy generation and efficiency.

He said: The research efforts of the agency are contributing enormously to abate exchange rate volatilities in Nigeria. A good example of this is cotton lint, a raw material for textile manufacturing. It was key on Nigerias import list, he said.

However, due to NABDAs collaboration with the Institute of Agricultural Research (IAR), Zaria, and Bayer and Mahyco Agricultural Nigeria Ltd, for the development, commercialization and deployment of new varieties of transgenic hybrid cotton, import of cotton lint is declining.

He said: Very soon, we shall attain self-sufficiency in the production of cotton. The point to underscore is, this Act by extension, would catalyze a resurgence of Nigerias Textile Industry.

Recall that the Textile Industry in Nigeria was a major employer of labour and revenue-earner in the 70s.

Furthermore, the agency, recently, formalized partnership with the Government of Cuba. The main objective of the partnership is to promote joint research in Tissue Culture, Drug and Vaccine manufacturing.

Speaking further, he said: Because of my background as an academic and actor in policy making space, it gives me a certain sense of elation to inform you that the Act, also, underlines the important nexus between innovative practice of biotechnology and research.

The Act encourages bridging the gap between laboratories and markets. It stipulates the formation of collaborative enterprises among research institutions and commercial sector.

This is why since my assumption of office as the Director General of NABDA, the commercialisation of research findings has been my clarion call.

QuoteWith this development, we are optimistic that the agency will be able to consolidate Nigerias leadership in Africas biotechnology space, and launch the nation into the stratosphere of global economic players

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Biotechnology Act to Crash Cost of Vaccines, Drugs Import, Drive Research THISDAYLIVE - THISDAY Newspapers

Sana Biotechnology Announces Multiple Preclinical Data Presentations to Showcase Its Hypoimmune Platform, Including in Type 1 Diabetes, at the…

SEATTLE, June 13, 2022 (GLOBE NEWSWIRE) -- Sana Biotechnology, Inc. ( SANA), a company focused on creating and delivering engineered cells as medicines, today announced that the company will present data from its hypoimmune platform at the International Society for Stem Cell Research (ISSCR) 2022 Annual Meeting taking place from Wednesday, June 15 through Sunday, June 19 in San Francisco.

About Sana BiotechnologySana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicines for patients. We share a vision of repairing and controlling genes, replacing missing or damaged cells, and making our therapies broadly available to patients. We are a passionate group of people working together to create an enduring company that changes how the world treats disease. Sana has operations in Seattle, Cambridge, South San Francisco, and Rochester.

Cautionary Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements about Sana Biotechnology, Inc. (the Company, we, us, or our) within the meaning of the federal securities laws, including those related to the companys vision, progress, and business plans, the Companys participation at the ISSCR Annual Meeting, and the subject matter of the Companys presentations and data being presented at ISSCR Annual Meeting. All statements other than statements of historical facts contained in this press release, including, among others, statements regarding the Companys strategy, expectations, cash runway and future financial condition, future operations, and prospects, are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as aim, anticipate, assume, believe, contemplate, continue, could, design, due, estimate, expect, goal, intend, may, objective, plan, positioned, potential, predict, seek, should, target, will, would and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. The Company has based these forward-looking statements largely on its current expectations, estimates, forecasts and projections about future events and financial trends that it believes may affect its financial condition, results of operations, business strategy and financial needs. In light of the significant uncertainties in these forward-looking statements, you should not rely upon forward-looking statements as predictions of future events. These statements are subject to risks and uncertainties that could cause the actual results to vary materially, including, among others, the risks inherent in drug development such as those associated with the initiation, cost, timing, progress and results of the Companys current and future research and development programs, preclinical and clinical trials, as well as the economic, market and social disruptions due to the ongoing COVID-19 public health crisis. For a detailed discussion of the risk factors that could affect the Companys actual results, please refer to the risk factors identified in the Companys SEC reports, including but not limited to its Quarterly Report on Form 10-Q dated May 10, 2022. Except as required by law, the Company undertakes no obligation to update publicly any forward-looking statements for any reason.

Investor Relations & Media:Nicole Keith[emailprotected][emailprotected]

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Sana Biotechnology Announces Multiple Preclinical Data Presentations to Showcase Its Hypoimmune Platform, Including in Type 1 Diabetes, at the...

Before Your Eyes, IMMORTALITY and 4 new Netflix Games coming out in July 2022 – Netflix Life

When people think of Netflix they dont often associate it with games, but Netflix has been gradually increasing the output of entertainment they add to the Netflix Games app.

At Geeked Week 2022, the streamer previewed what looks like a fantastic slate of upcoming games coming soon to the service. The best part is, there are no ads or microtransactionstwo things that plague a lot of mobile gaming services.

All you need is a Netflix subscription and you can enjoy everything the app has to offer. This July, Netflix is adding at least four new games to the service.

Netflix sent out the July 2022 newsletter and included four new games. Unfortunately, the streamer has not provided exact release dates for any of the games, but it does say each of the four is coming soon, and given their inclusion on the July newsletter we can safely assume all four of the games detailed below will be available in the next month.

Wild Things: Animal Adventures screenshot Cr. Netflix

From the devs who brought usHarry Potter: Hogwarts Mystery comes a new Match-3 puzzle game. For those unfamiliar with the term, a Match-3 game invites players to manipulate tiles and identify patterns to make them disappear and clear the board.

The immersive Wild Things: Animal Adventure game features a cast of stunning, 3D animated animals. Players must help these creatures save their homelands. Rescue adorable animals and explore an immersive world as you build your dream habitat in this puzzle adventure game.

Release date: TBA

Before Your Eyes. Cr: Netflix.

The BAFTA award-winning first-person adventure game Before Your Eyes is an emotional story that allows players to control a story and affect an outcome with your real-life blinks. Using an innovative technique, players can fully immerse themselves in a world of memories as they help the character of Benjamin Brynn on his way to the afterlife.

To interact with the Benjamins memories, players will respond to the surroundings and game via an eye-tracking webcam in your mobile phone. The game reads and responds to your eye movement and blinking.

Until now, the game has only been available to play via Microsoft Windows from retailers like Steam and Epic Games. Its pretty exciting that soon many more gamers will get the chance to play.

Release date: TBA

Before Your Eyes. Cr: Netflix.

Mahjong Solitaire. Cr: Netflix.

Do you like playing Mahjong? What about Solitaire? In a game that combines the best of both worlds, Mahjong Solitaire promises to be a fun and rewarding new addition to the Netflix Games app.

Enjoy hundreds of tile-matching puzzles. Equip themes and backgrounds, including Stranger Things ones, to change the games look and feel! Below you can get a peek at what some of the different themes look like, including the Stranger Things setting.

Release date: TBA

Mahjong Solitaire. Cr: Netflix.

Mahjong Solitaire. Cr: Netflix.

IMMORTALITY. Cr: Netflix.

From the creator of Her Story comes a new explorative narrative game about the lost works of a silver-screen hopeful named Marissa Marcel. Before her disappearance, Marissa made three movies, but none were ever released. Now youll need to explore her lost works to find clues that could unlock the secrets to her vanishing.

Based on the descriptors used to catalog this game, it sounds like IMMORTALITY is a mix of simulation, horror, cinematic and adventure games.

It will be released on Steam on July 26, 2022, so it seems likely that IMMORTALITYwill arrive on Netflix either that same day or the following week.

Release date: TBA

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Before Your Eyes, IMMORTALITY and 4 new Netflix Games coming out in July 2022 - Netflix Life

What is Klaus Hargreeves power in The Umbrella Academy? – Netflix Life

The self-described spiritual one of the Hargreeves siblings and The Umbrella Academy, Klaus Hargreeves (Robert Sheehan) has several powers and abilities that revolve around death and the void.In The Umbrella Academy season 3, Klaus finally starts to learn more about his abilities with some surprising assistance from an unlikely source.

Spoilers ahead for The Umbrella Academy season 3

In the third season, the new, alternate-timeline version of Reginald Hargreeves (Colm Feore) opts to assist his son with learning how to control his powers, namely his immortality. The show has strongly hinted at Klaus immortality in previous seasons, but it really delves into it in the latest batch of episodes and confirms, without a doubt, that Klaus is immortal and has died and come back many times already.

But what is the extent of Klaus powers?

Klaus can communicate with the dead. However, when he was a child, Reginald locked him in a crypt with a bunch of ghosts, so he has always been more hesitant to use his abilities due to fearing the undead. The only ghost we have seen him communicate with on a consistent basis is his brother, Ben Hargreeves (Justin H. Min). But Reginald has always suggested that Klaus is unaware of his true potential.

Its not just that he can talk to spirits like a medium, but Klaus is also able to conjure spirits. He did so with Reginald and weve seen him do it with other ghosts in different circumstances, summoning them to help him mid-battle or otherwise. In the second season, Klaus also starts interacting with Ben in a more physical capacity, even allowing Ben to take possession of his body for brief spells.

The third season really digs into Klaus immortality. After Stanley(Javon Wanna Walton) accidentally kills Klaus with a harpoon gun in the White Buffalo Suite, Klaus finds himself in the void where he meets the spirit of his mother. Later, he and Reginald try to figure out how Klaus can die and return to life more quickly, ultimately teaching Klaus how to successfully resurrect himself within just minutes of death. We learn that many of Klaus brushes with death from the past were really him dying and coming back to life.

Klaus increased mastery of his powers is shown at the end of The Umbrella Academy season 3 when he creates a safe place for Luthers spirit(Tom Hopper) and travels to Hotel Oblivionfrom the void to assist his siblings.

The Umbrella Academy season 3 is now streaming on Netflix.

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What is Klaus Hargreeves power in The Umbrella Academy? - Netflix Life

The Most Hated Characters in ‘Fullmetal Alchemist: Brotherhood’ – We Got This Covered

Fullmetal Alchemist: Brotherhood is considered one of the greatest anime of all time. Written by Hiromu Arakawa, the world of Fullmetal Alchemist is fantasy-meets-science fiction, where individuals can learn to use alchemy an ability to change the matter around them with many specializing in specific fields.

The story follows Edward and Alphonse Elric, two talented young alchemists that are seeking a philosophers stone so they may return to their original forms, which were lost when they tried to go beyond the natural bounds of alchemy by attempting to resurrect their dead mother through human transmutation. They are not the only ones seeking the ability to create a stone, but what contrasts the two protagonists with the more villainous characters in the anime, is what they are willing to do, or in their case not do in order to attain this power.

They join the military as State Alchemists and quickly discover that there is something deeply wrong with their country. Through their research, they uncover a government-wide conspiracy and the disturbing truth behind why their country, Amestris, is a land of peace surrounded by war.

The central theme of the story is human nature, looking at humanitys best and worst, but also the gray areas in between. Arakawa writes villains just as well as the protagonists, each one has their own motivation and methods. Many characters are so caught up in their own desires and goals that they are happily willing to sacrifice anyone and everyone to attain them, whereas others simply enjoy sowing fear and destruction.

In a show littered with questionable characters ranging from genocidal megalomaniacs to sadistic thrill seekers these are the top 10 most hated characters.

Cornello only appears in the third episode of Fullmetal Alchemist: Brotherhood, but he is quite the detestable character who uses peoples desire for hope to con them as a religious man. Some fans believe that his story was better served in the original anime, but Brotherhood glossed over it a little seeing as it had already been done before.

Cornello allowed himself to be used by the homunculi to create civil unrest desiring wealth and power believing he could create an army of religious zealots that would die for him. Manipulating religious belief for your own gain is not uncommon in the real world as well and makes an individual easily hateable.

He is the first of Fathers homunculi children and embodies the nature of Pride. Discovering that sweet little Selim Bradley, son to the King, was actually the oldest and most deadly of the homunculi was a great twist in the story. Pride cares little for his siblings, easily killing and absorbing Gluttony in order to gain his skills. He is narcissistic and self-aggrandizing, exactly what you would expect for the embodiment of the sin pride.

The only real feeling he ever lets on to is that he cares somewhat for his adoptive mother. So perhaps there is a shred of humanity in him somewhere.

As with many of the villainous characters enamored with the offer of immortality, General Raven has a rather Machiavellian approach to life. Originally trusted by Mustang for his kind nature, Raven eventually reveals his true colors and just how far the level of corruption goes when he shows Mustang that all of Central Command is in on the plan to sacrifice millions for the immortality of a few.

He is tricked into revealing his plans to Major General Olivier Armstrong, whom he tries to seduce with the promise of immortality, in a slightly lecherous way as well. He is so desperate to see the plan come to fruition before he dies that he fails to notice he is being used as a pawn by Father.

Many hate Wrath simply because he had us fooled for quite some time. Wrath first appears to the audience as King Bradley, ruler of Amestris and head of the military. At first, he seems genuinely quite pleasant and laid back for a ruler even mischievous at times but we come to realize its all a ruse. The man has a tremendous amount of fury that he struggles to contain as he is actually the vessel for the homunculus wrath.

Unlike the other homunculi, Wrath is still human and separates himself somewhat from the others, even going as far as sympathizing with humanity from time to time. Where fans come to hate him though was when, during Hughes funeral, what at first appeared to be him shaking out of grief for his fallen soldier, turned out to be him shaking in anger as Hughes daughter ruined the silence with her crying.

He is a confusing character but seeing as he seems happy with the plan to sacrifice the nation he is meant to serve, fans have every right to hate him.

This creepy character works behind the scenes enacting Fathers plans. He is seen in the flashbacks to be the one administering Bradley with the liquid philosophers stone to create Wrath, a procedure that had multiple fatal failures before. The doctor is happy to experiment on individuals to further Fathers goals, but also to gain more knowledge for himself, blinded to humanity by his own desire to see his experiments work.

He tries to force Colonel Mustang to open up a gate of truth by slashing Riza Hawkeyes throat in front of him, which would have forced him to use human transmutation. The doctor is happy to use others, including the men he trained, as pawns to sacrifice their lives for his cause but proves to be a coward when its his own life at risk.

Though this character has very little screentime, his actions are enough to cause some major hate to be aimed at him. As the ruler of Xerxes, a prosperous and advanced land, the king seemed to be originally well-liked by his subjects. But as he aged and death drew near he became frantic to avoid his fate, desperate enough to go along with the plan of The Dwarf in the Flask and sacrifice the lives of his entire kingdom in order for himself and his court to gain immortality.

Of course, he didnt exactly get what he bargained for and died alongside his countrymen, to create the first-ever philosophers stone. He was the first in a long line of humans that allowed themselves to be manipulated by the homunculus for their own greed.

Kimblees twisted mind is despicable and his actions are considered more so because he is human and yet acts in such an inhumane way. As a State Alchemist during the Ishval war, Kimblee reveled so much in the destruction that he used his explosive style of alchemy on innocent targets. These acts caused him to be imprisoned after the war ended, though he was later released by the corrupt government when they had a need for him.

Kimblee is an interesting amoral character, happy to observe from the sidelines or get involved with either side, depending on how he feels about it. He genuinely respects those with strong abilities and convictions and will attack anything he believes to show weakness, even taking on Pride from within when the homunculi strays from his ideals.

He delights in causing pain, saying that the screams of tortured souls are but a lullaby to him, and he fully deserves the hate that he gets for his lack of empathy and humanity.

Father was the original Homunculus, created eight centuries prior to the main story in the now lost city of Xerxes. Created through alchemy and using the blood of a slave boy who would become Van Hohenheim they manipulate the desperate King into believing he can reach immortality by sacrificing all of his people, only to betray him and use the sacrifices to create a philosophers stone powerful enough to grant him his own immortal body.

They seek to overthrow God, which requires enormous power, so they create the land of Amestris ruling from the wings, planning wars in specific areas to create a huge alchemical transmutation circle powered by the bloodshed. The transmutation circle would then sacrifice everyone within it in order to grant Father the power to tackle God or Truth as he is known.

His complete disregard for anyones life but his own creating violence and instigating wars over centuries for his own selfish ends marks him as one of the greatest villains in anime history.

Despite not being the big bad of the show, Envy has earned the ire of fans for their truly despicable acts. As one of the seven homunculi, Envy has the ability to transform into anyone. They are responsible for the shocking death of one of the series most beloved characters, Maes Hughes, a family man who loved his wife and daughter beyond all things.

Not only did they kill Hughes, but they took the form of his wife to do so, causing Hughes to pause before striking, making the last thing he saw the image of his wife grinning as she killed him. They then set up Second Lieutenant Maria Ross for the murder of Hughes leading to her execution which she thankfully escaped with the help of Colonel Mustang.

Not to mention it was their actions that were the catalyst for the bloody war in Ishval when they took on the shape of an Amestris soldier and shot dead a young Ishvalan girl. They delight in causing chaos, pain, and suffering, seeing humans as nothing but worms beneath them, though through their tragic and pathetic defeat we come to realize how much they envy humans.

Shou Tucker is not just the most hated character from FMA: Brotherhood, but often tops the list of most hated anime characters. For a character that doesnt even get that much screentime, its an impressive feat, one he has achieved by committing one of the most heinous acts in anime history.

Scared of losing his license having not produced anything of note since his last chimera two years prior Tucker uses his adorable young daughter Nina and the family dog, Alexander, to create a new one. When showing his creation to the Elric brothers, the chimera looks at Edward and says Edward Big Brother, causing a horrified Edward to grasp the truth. Edward surmises that the first chimera was Tuckers missing wife and then attacks the scientist who claims that all science requires sacrifice and that human testing is to be expected when advancing science.

Fans were truly disgusted by the scientists actions, finding him utterly repulsive and pathetic, and have since viewed him as one of the most detestable anime characters of them all.

Watch all these villains in action, as Fullmetal Alchemist: Brotherhood is available to stream on multiple platforms, including Netflix, Hulu, and Crunchyroll.

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The Most Hated Characters in 'Fullmetal Alchemist: Brotherhood' - We Got This Covered

The best games on Xbox in July 2022 – including F1 22, Immortality and Klonoa – NationalWorld

Junes live-stream bonanza, which took place instead of the usual E3 shenanigans (cancelled once more due to ongoing Covd concerns) has gamers hyped for whats to come.

Here are the five Xbox games were most looking forward to getting our hands on in the coming month.

F1 22

What is it? Very much to Formula 1 what the FIFA games are to football, F1 22s is EAs latest in its annual series of racing games that replicate the sport unlike any others.

As new regulations in real-world races have changed the shape, design and handling profiles of the cars, so too do they in-game, with new car models with updated physics making for a realistic experience.

Tracks have been updated too, with updated course layouts reflecting their real-world counterparts, and the introduction of the Miami International Autodrome for calendar newcomer, the Miami Grand Prix.

Formula 2 racing is also included in the game, which also introduces a new adaptive AI system, which adjusts the pace of computer-controlled cars according to players skill to ensure competitive races every time.

When can I play it? 1 July

Matchpoint Tennis Championships

What is it? Matchpoint might not quite be able to match F1 22s uncanny ability to reproduce a real-world sport, but its virtual representation of tennis is certainly the best weve seen for a long while.

Still, you do get 16 licensed players including some of the biggest racket stars in the world - like Nick Kyrgios and Amanda Anisimova - as well as 26 world famous courts.

You can also create your own player if you want to take yourself to the top of the tennis standings, and Matchpoint is promising a deep career mode featuring a unique merit-based ranking system.

When can I play it? 7 July (also available through Game Pass)

Klonoa Phantasy Reverie Series

Updated to run in 60fps and up to 4K resolution with added features such as adjustable difficulty and a two-player cooperative mode, Klonoa: Door to Phantomile and Klonoa 2: Lunateas Veil will be available to a whole new generation of fans.

Players take control of Klonoa, whose primary attack involves grabbing enemies with the Wind Ring, an object that fires a small burst of air forward that inflates and pulls enemies back to him to carry.

From here, youll be able to throw captured foes, or use them to perform a double-jump in midair, allowing you to reach greater heights and bypass obstacles.

When can I play it? 8 July

Endling: Extinction is Forever

What is it? Usually, survival games are not this writers cup of tea. Their open-ended gameplay is no match for a well crafted narrative, and the idea that you WILL succumb to the elements - its just a matter of how long you can stave them off - has always proved much too stress inducing.

But, Endling could change that. With a strong environmental message that sees players take control of the last mother fox on Earth attempting to protect her cubs from a world slowly crumbling to the effects of humanity, its got a rather striking artstyle to boot.

Youll explore areas for supplies with which to defend your babies, feeding them and watching them grow into young foxes with unique personalities and fears, and use the cover of night to stealthily guide your litter towards a safer place.

When day break comes, its time to use the relative safety of the light to improve your shelter and plan your next move.

When can I play it? 19 July

Immortality

What is it? Sam Barlows Her Story is often credited as one of the most uniquely intriguing games in recent years, and saw players sift through live-action video clips of police interviews to piece together the narrative.

Immortality takes a similar approach, but this time youre on the hunt for Marissa Marcel, an unfortunate actress who starred in three films that were never released.

Shes since gone missing, and players will have to scour clips of her unseen films - as well as behind-the-scenes footage of their making - to find clues and hints to people of interest.

It sounds like another reality blurring endeavour from Barlow, and since its coming to Game Pass on day of release, theres no reason for Xbox fans not to check it out.

When can I play it? 26 July (also available through Game Pass)

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The best games on Xbox in July 2022 - including F1 22, Immortality and Klonoa - NationalWorld

Book tells tale of 1920s reporters who warned the world of the war that was coming – Kingsport Times News

There is no immortality for newspaper reporters.

One of them, Ben Hecht, addressed this matter in a short poem written long ago: We know each others daydreams / And the hopes that come to grief / For we write each others obits / And theyre Godalmighty brief.

There is no immortality for newspaper reporters, but Deborah Cohen has done a remarkably powerful, enlightening and entertaining job of bringing back to life a quartet of long gone reporters along with dozens of other interesting sorts, in her new book, Last Call at the Hotel Imperial: The Reporters Who Took on a World at War (Random House).

It is a journey, she writes, into the 1920s and 1930s, (when) millions of Americans got their news from a very small number of international reporters. In the interwar years, American foreign correspondents became the kings of the hill. Armed with a peculiarly American obsession with personalities, they sounded an early warning about the rise of the dictators.

She focuses on four of them, each a vessel of immense curiosity and energy.

There was Chicago-born John Gunther, who was a student at the University of Chicago before becoming a reporter for the Chicago Daily News, where he struck his colleagues as a young man going somewhere. Did he ever, taking off for Europe with no job (he had quit the News) and $150 in his pocket but with big ambitions. He would report prolifically and marry another writer named Frances. He would become a bestselling author with what was known as the Inside books, a series that included the bestseller Inside U.S.A in 1947. He basically invented the grief memoir with the heart-wrenching 1949 book about his young sons death, Death Be Not Proud, which is sadly the only one of his many books still in print.

H.R. Knickerbocker, Knick to his friends, was Texas-born and won the Pulitzer Prize in 1931 for his newspaper series on Stalin.

Vincent (Jimmy) Sheean came to the University of Chicago from tiny downstate Pana, Illinois, and was soon reporting from far, far away, from Spain and elsewhere. His 1935 political memoir Personal Historybecame the inspiration for Alfred Hitchcocks 1940 film Foreign Correspondent.

Dorothy Thompson, perhaps the most famous of the gang, was a native New Yorker. As she wrote to a friend in 1921, when she was in her late 20s, I have been a wild cat walking by my wild lone self most of my life since 16. What she did becoming the first female syndicated political columnist and a radio broadcaster, made her so prominent that, as Cohen tells us, On the eve of the Second World War, Time magazine described Thompson and Eleanor Roosevelt as the most influential women in the United States. She was also married for a helter- skelter time to novelist Sinclair Lewis. Her life became the inspiration for the Spencer Tracy and Katharine Hepburn 1942 film Woman of the Year.

Cohen informs us of so much, bringing the characters of this era to vivid and raucous life. She makes them all unforgettable, and allows us to understand what made them tick and work as they visited European capitals and traveled to Asia, the Middle East and Africa.

Their Midwestern roots were crucial, she says. They understood their readers. They were able to speak to Americans. They were as famous in their time as famous could be and they were also pioneers in new journalism. They were subjective, intimate, emotional, powerful.

They also had active social and drinking lives. They were in and out of each others lives, sharing late nights, talking, sharing beds, Cohen says.

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As she writes, Even when they were far apart, even after they fell out, they kept right on talking and arguing, long after the conversations had ended.

The eight years Cohen devoted to researching and writing this splendid book was time well spent. We encounter in fresh ways such figures as Hitler, Mussolini, Gandhi, Nehru and Stalin. We also meet such now-forgotten people as Polly Adler, the proprietor of Manhattans most famous brothel and a friend of Gunthers: It was difficult to find girls to work because they were all doing war service, she told John. The sexual peculiarities these days! The higher the tensions got in Europe, the stranger the perversions.

So prolific and active were the reporters that they make the most famous writer of the period, a fellow named Hemingway, seem a slacker by comparison.

The maps detailing the travels of these reporters are admirable and dizzying. As Gunther would put it later, We were scavengers, buzzards, out to get the news, no matter whose wings got clipped.

Cohen was born and raised in Louisville and at a tender age flirted with a career as a newspaper reporter. She started and edited a paper in high school but, admitting to being hijacked by archives, earned a degree in history and womens studies at Harvard-Radcliffe and then a masters and doctorate at the University of California at Berkeley. She taught at American University and Brown University before coming to Northwestern in 2010, where she now academically resides, living in the Lakeview neighborhood with her husband and teenage daughter.

I love teaching, first-year students to graduate level, she says.

She is also a writer of palpable power and deep understanding.

After WWII, her quartet, more or less, she says, moved off stage. Their moment was the moment of warning, so once the conflict started, what was there for them to say, I told you so?

In their time they told us more than enough and they came at us in an intimate fashion. Cohen writes with easy authority and a powerful narrative drive. This is a great book about great and flawed people caught up in a world going mad.

She credits the voluminous archives that she pored through for making it possible to capture the texture and the course of (her subjects) thoughts at very close hand My aim as an author has been to follow their own lead as journalists to convey how it felt to lie so exposed to history in the making.

For what its worth, Cohen would have made one hell of a reporter.

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Book tells tale of 1920s reporters who warned the world of the war that was coming - Kingsport Times News

Games With Gold July 2022 Reveal Overshadowed By Xbox Game Pass – HITC – Football, Gaming, Movies, TV, Music

The Games With Gold July 2022 reveal is happening this week and already looks to be overshadowed by the Xbox Game Pass titles confirmed for next month.

In total, there are already five titles confirmed for Microsofts other subscription service, the first arriving on July 1.

And this will be going up against whatever the tech giant has planned for Games with Gold during July 2022.

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Microsoft has not confirmed the exact date for its Games With Gold July 2022 reveal, something will be revealed before Friday, July 1, 2022. This will be the date that the first games are launched, one for Xbox One and one from Xbox 360. This means that Microsoft will need to share its plans sometime over the coming days.

Here are some of the dates used to share Games with Gold by Microsoft over previous months:

Four games will be available to download during July 2022, with most of the biggest games saved for Xbox Game Pass. And while we dont know what titles will be released on Games With Gold next month, we have some news regarding Xbox Game Pass.

Five titles have been revealed as arriving throughout the month, starting with Far Cry 5 on July 1, quickly followed by Last Call BBS on July 5 and Matchpoint Tennis Championships on July 7. The second half of the month will see the arrival of As Dusk Falls on July 19, and Immortality on July 26.

Meanwhile, with Game with Gold, the first two free games will be sourced from Xbox One and Xbox 360, for July 1, followed by a second batch going live on July 16, Some of these games will only be available for two weeks, while others will remain available for a full four weeks. Gamers will also note that PS Plus Premium has now launched and will be offering a much meatier rival to Microsofts GwG and Xbox Game Pass subscription services.

In other news, Games With Gold July 2022 Reveal Overshadowed By Xbox Game Pass

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Games With Gold July 2022 Reveal Overshadowed By Xbox Game Pass - HITC - Football, Gaming, Movies, TV, Music

‘You Made Generations Laugh’: Martin Lawrence Shares Touching Video That He Will Receive a Star on the Hollywood Walk of Fame – Atlanta Black Star

Congratulations are in order for veteran comedian and actor Martin Lawrence. He and several other Black stars, including Ludacris, Charlie Wilson and Lenny Kravitz, will be honored for their contributions to the entertainment industry with their very own star on Hollywoods Walk of Fame.

The Bad Boys For Life star made the big reveal over the weekend with a Twitter post showing his reaction to hearing the achievement. In the clip, legendary radio host Ellen K, who serves as the chair of the Chambers Walk of Fame selection committee, announced the honorees from the television category, including the Martin star, who jumped in excitement at the calling of his name.

Ya boy is gettin his own star on the Hollywood Walk of Fame! An absolute honor to be among icons of entertainment! @hwoodwalkoffame #classof3032 #blessed, the 57-year-old actor wrote in the caption.

Fans flocked to the comments section where they congratulated the Big Mommas House star on his victory, including one Twitter user who wrote, Its About time Yes Sir Our Boy oh Marty @realmartymar Finally long Due you deserves All your Flowers you made generations laugh Congratulations You deserve the honor you earned it through hard work & dedication thanks for giving the Sheneneh Mama Payne Otis Jerome Def comedy.

Another person commented, Congratulations on your good star its well deserved and it shows that even when others try to silence you, God has other plans for you. Its a testament of the talent you have for comedy and now celebrity immortality. That person added, You the man.

Long time coming! wrote a YouTube fan. This shouldve been done a long time ago! If anybody deserves this, its you. Youve had SO much impact on me, and even my personality just growing up watching you. Congratulations, and much love Mr Martin Lawrence. Go Celebrate!

Ludacris also shared his announcement on his social media account, writing, Hey Momma, Your Son Is Being Selected To Receive a STAR on the Hollywood Walk of Fame in 2021 GOD IS THE GREATEST.

Aforementioned, the actors are just two of seven Black stars joining the prestigious club. Garrett Morris, Melba Moore and late actress Juanita Moore, the fifth Black person to receive an Academy Award in any category, also will be honored.

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'You Made Generations Laugh': Martin Lawrence Shares Touching Video That He Will Receive a Star on the Hollywood Walk of Fame - Atlanta Black Star

Dolphins will honor 1972 team’s 50-year anniversary in Week 7 – Dolphins Wire

This season will be the 50th anniversary of the greatest team in the history of professional football the 1972 Miami Dolphins, who stand as the only team to cap an undefeated season with a Super Bowl championship.

The Miami Heralds Barry Jackson reported Monday that the 72 team will be honored during the Sunday night matchup on Oct. 23 (Week 7) against the Pittsburgh Steelers.

That team was in the middle of three straight Super Bowl appearances a loss against the Dallas Cowboys in the 1971 season that was followed by a pair of titles in 1972 and 1973.

Unfortunately, on the same day that the 50th-anniversary celebration was announced, another member of the 1972 team passed away pioneer quarterback and wide receiver Marlin Briscoe.

Briscoe became the first Black starting quarterback in modern American professional football in 1968 for the Denver Broncos, then became a wide receiver and spent three years playing for Miami from 1972-1974.

During the Week 7 celebration, many Miami legends are sure to raise glasses of champagne to toast and remember 1972, the team and the individuals. Especially those who will be honored posthumously, such as Hall of Famer Nick Buoniconti, the legendary Jim Mad Dog Mandich and other popular Dolphins such as Jake Scott, Jim Kiick and Bob Kuechenberg, to name a few. And, of course, Hard Rock Stadium will once again get an opportunity to honor the greatest to ever coach a group of football players, Don Shula.

While the legends will be out in spirit and on the sidelines against the Steelers on Oct. 23, you can imagine a grand celebration for a feat that has never been replicated.

While there have been a few scares within those 50 years of another franchise meeting Miami on the mountain of football immortality, it was a Dolphin himself who made sure it didnt happen in 1985. Dan Marino led the Dolphins against a 12-0 Bears juggernaut, and the Bears defense was mastered by Marino as the Dolphins beat Chicago 38-24. Shula brought out his players-of-perfect past, as Larry Csonka and company roamed the sideline in hopes of retaining the sole place in Perfectville.

Most recently, the 2007 New England Patriots ran the regular season gamut perfectly to 16-0. However, a miraculous throw and catch by New York Giants Eli Manning and David Tyree in Super Bowl XLII ended perfection for the Pats.

It will be an amazing atmosphere at Hard Rock Stadium for the nationally televised Sunday night contest. With the number of former Dolphins supporting a current group of players, as well as a few former players and coaches on the opposite side of the field, the storylines are rife with intrigue.

Not only will the Dolphins honor their landmark achievements 50th anniversary, but they will also go against two familiar faces: former head coach Brian Flores, who is now an assistant coach for the Steelers defense, and safety Minkah Fitzpatrick, a former first-round pick of Miamis.

Regardless of how appealing that side note is for a prime-time game, Dolphins fans and football historians will no doubt be treated to a proper honoring of an accomplishment thats treasured by fans young and old.

Miami will look to make Week 7 a perfect Sunday night with a toast and, hopefully, cap off with a win.

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Dolphins will honor 1972 team's 50-year anniversary in Week 7 - Dolphins Wire

Welcome to the land that no country wants

Bir Tawil is the last truly unclaimed land on earth: a tiny sliver of Africa ruled by no state, inhabited by no permanent residents and governed by no laws. To get there, you have two choices.

The first is to fly to the Sudanese capital Khartoum, charter a jeep, and follow the Shendi road hundreds of miles up to Abu Hamed, a settlement that dates back to the ancient kingdom of Kush. Today it serves as the regions final permanent human outpost before the vast Nubian desert, twice the size of mainland Britain and almost completely barren, begins unfolding to the north.

There are some artisanal gold miners in the desert, conjuring specks of hope out of the ground, a few armed gangs, which often prey upon the prospectors, and a small number of military units who carry out patrols in the area and attempt, with limited success, to keep the peace. You need to drive past all of them, out to the point where the occasional scattered shrub or palm tree has long since disappeared and given way to a seemingly endless, flat horizon of sand and rock out to the point where there are no longer any landmarks by which to measure the passing of your journey.

Out here, dry winds often blow in from the Arabian peninsula, whipping up sheets of dust that plunge visibility down to near-zero. After a day like this, then a night, and then another day, you will finally cross into Bir Tawil, an 800-square-mile cartographical oddity nestled within the border that separates Egypt and Sudan. Both nations have renounced any claim to it, and no other government has any jurisdiction over it.

The second option is to approach from Egypt, setting off from the countrys southernmost city of Aswan, down through the arid expanse that lies between Lake Nasser to the west and the Red Sea to the east. Much of it has been declared a restricted zone by the Egyptian army, and no one can get near the border without first obtaining their permission.

In June 2014, a 38-year-old farmer from Virginia named Jeremiah Heaton did exactly that. After obtaining the necessary paperwork from the Egyptian military authorities, he started out on a treacherous 14-hour expedition through remote canyons and jagged mountains, eventually wending his way into the no mans land of Bir Tawil and triumphantly planting a flag.

Heatons six-year-old daughter, Emily, had once asked her father if she could ever be a real princess; after discovering the existence of Bir Tawil on the internet, his birthday present to her that year was to trek there and turn her wish into a reality. So be it proclaimed, Heaton wrote on his Facebook page, that Bir Tawil shall be forever known as the Kingdom of North Sudan. The Kingdom is established as a sovereign monarchy with myself as the head of state; with Emily becoming an actual princess.

Heatons social media posts were picked up by a local paper in Virginia, the Bristol Herald-Courier, and quickly became the stuff of feel-good clickbait around the world. CNN, Time, Newsweek and hundreds of other global media outlets pounced on the story. Heaton responded by launching a global crowdfunding appeal aimed at securing $250,000 in an effort at getting his new state up and running.

Heaton knew his actions would provoke awe, mirth and confusion, and that many would question his sanity. But what he was not prepared for was an angry backlash by observers who regarded him not as a devoted father or a heroic pioneer but rather as a 21st-century imperialist. After all, the portrayal of land as unclaimed or undeveloped was central to centuries of ruthless conquest. The same callous, dehumanising logic that has been used to legitimise European colonialism not just in Africa but in the Americas, Australia, and elsewhere is on full display here, noted one commentator. Are white people still allowed to do this kind of stuff? asked another.

Any new idea thats this big and bold always meets with some sort of ridicule, or is questioned in terms of its legitimacy, Heaton told me last year over the telephone. In his version of the story, Heatons conquest of Bir Tawil was not about colonialism, but rather familial love and ambitious dreams: apart from making Emily royalty, he hopes to turn his newly founded nation which lies within one of the most inhospitable regions on the planet and contains no fixed population, no coastline, no surface water and no arable soil into a cutting-edge agriculture and technology research hub that will ultimately benefit all humanity.

After all, Heaton reasoned, no country wanted this forgotten corner of the world, and no individual before him had ever laid claim to it. What harm was to be caused by some wellintentioned, starry-eyed eccentric completing such a challenge, and why should it not be him?

There were two problems with Heatons argument. First, territories and borders can be delicate and volatile things, and tampering with them is rarely without unforeseen consequences. As Heaton learned from the public response to his self-declared kingdom, there is no neutral or harmless way to claim a state, no matter how far away from anywhere else it appears to be. Second, Heaton was not the first well-intentioned, starry-eyed eccentric to travel all the way to Bir Tawil and plant a flag. Someone else got there first, and that someone was me.

Like all great adventure stories, this one began with lukewarm beer and the internet. It was the summer of 2010, and the days in Cairo where I was living and working as a journalist were long and hot. My friend Omars balcony provided a shaded refuge filled with wicker chairs and reliably stable wireless broadband. It was up there, midway through a muggy evenings web pottering, that we first encountered Bir Tawil.

Omar was an Egyptian-British filmmaker armed with a battery of finely tuned Werner Herzog impressions and a crisp black beard that I was secretly quite jealous of. The pair of us knew nothing beyond a single fact, gleaned from a blog devoted to arcane maps: barely 500 miles away from where we sat, there apparently existed a patch of land over which no country on earth asserted any sovereignty. Within five minutes I had booked the flights. Omar opened two more beers.

Places beyond the scope of everyday authority have always fired the imagination. They appear to offer us an escape when all you can see of somewhere is its outlines, it is easy to start fantasising about the void within. No mans lands are our El Dorados, says Noam Leshem, a Durham University geographer who recently travelled 6,000 miles through a series of so-called dead spaces, from the former frontlines of the Balkans war to the UN buffer zone in Cyprus, along with his colleague Alasdair Pinkerton of Royal Holloway. The pair intended to conclude their journey at Bir Tawil, but never made it. There is something alluring about a place beyond the control of the state, Leshem adds, and also something highly deceptive. In reality, nowhere is unplugged from the complex political and historical dynamics of the world around it, and as Omar and I were to discover no visitors can hope to short-circuit them.

Six months later, in January 2011, we touched down at Khartoum International airport with a pair of sleeping bags, five energy bars, and an embarrassingly small stock of knowledge about our final destination. To an extent, the ignorance was deliberate. For one thing, we planned to shoot a film about our travels, and Omar had persuaded me the secret to good film-making was to begin work utterly unprepared. Omar according to Omar was a cinematic auteur; the kind of maverick who could breeze into a desolate wasteland with no vehicle, no route, and no contacts and produce an award-winning documentary from the mayhem. One does not lumber an auteur, he explained, with printed itineraries, booked accommodation or emergency phone numbers. Mindful of my own aspirations to auteurism, this reasoning struck me as convincing.

There was something else, too, that made us refrain from proper planning. As the date of our departure for Sudan drew closer, Omar and I had taken to discussing our plans for Bir Tawil in increasingly grandiose terms. Deep down, I think, we both knew that the notion of claiming the territory and harnessing it for some grand ideological cause was preposterous. But what if it wasnt? What if our own little tabula rasa could be the start of something bigger, transforming a forgotten relic of colonial map-making into a progressive force that would defeat contemporary injustices across the world?

The mechanics of how this might actually work remained a little hazy. Yet just occasionally, at more contemplative junctures, it did occur to us that in the process of planting a flag in Bir Tawil as part of some ill-defined critique of arbitrary borders and imperial violence, there was a risk we could appear to the untrained eye very similar to the imperialists who had perpetrated such violence in the first place. It was a resemblance we were keen to avoid. Undertaking this journey in a state of deep ignorance, we told ourselves, would help mitigate pomposity. Without any basic knowledge, we would be forced to travel as humble innocents, relying solely on guidance from the communities we passed through.

As the two of us cleared customs, we broke into smiles and congratulated each other. The auteurs had landed, and what is more they had Important Things To Say about borders and states and sovereignty and empires. We set off in search of some local currency, and warmed to our theme. By the time we found an ATM, we were referring to Bir Tawil as so much more than a conceptual exposition. Under our benevolent stewardship, we assured each other, it could surely become some sort of launchpad for radical new ideas, a haven for subversives all over the planet.

It was at that point that the auteurs realised their bank cards did not work in Sudan, and that there were no international money transfer services they could use to wire themselves some cash.

This setback represented the first consequence of our failure to do any preparatory research. The nagging sense that our maverick approach to reaching Bir Tawil may not have been the wisest way forward gained momentum with consequence number two, which was that to solve the money problem we had to persuade a friend of a friend of a friend of an Egyptian business acquaintance to do an illicit currency trade for us on the outskirts of Khartoum. Consequence number three namely that, given our lack of knowledge about where we could and could not legally film in the capital, after a few days we inadvertently attracted the attention of an undercover state security agent while carrying around $2,000 worth of used Sudanese banknotes in an old rucksack, and were arrested transformed suspicion into certainty.

On the date Omar and I were incarcerated, millions of citizens in South Sudan were heading to the polls to decide between continued unity with the north or secession and a new, independent state of their own. We sat silently in a nondescript office block just off Gamaa Avenue the citys main diplomatic thoroughfare while a group of men in black suits and dark sunglasses scrolled through files on Omars video camera. Armed soldiers, unsmiling, stood guard at the door. Through the rooms single window, open but barred, the sound of nearby traffic could be heard. The images on the screen depicted me and Omar gadding about town on the days following our arrival; me and Omar unfurling huge rolls of yellowing paper at the governments survey department; me and Omar scrawling indecipherable patterns on sheets of paper in an effort to design the new Bir Tawili flag; me and Omar squabbling over fabric colours at the Omdurman market where we had gone to stitch together the aforementioned flag. With each new picture, a man who appeared to be the senior officer raised his eyes to meet ours, shook his head, and sighed.

In an attempt to lighten the mood, I pointed out to Omar how apposite it was that at the very moment in which votes were being cast in the south, possibly redrawing the regions borders for ever, we had been placed under lock and key in a military intelligence unit almost a thousand miles to the north for attempting to do the same. Omar, concerned about the fate of both his camera and the contents of the rucksack, declined to respond. I predicted that in the not too distant future, when we had made it to Bir Tawil, we would look back on this moment and laugh. Omar glared.

In the end, our captivity lasted under an hour. The senior officer concluded, perceptively, that, whatever we were attempting to do, we were far too incompetent to do it properly, or to cause too much trouble along the way. Upon our release, we set about obtaining a jeep that could take us to Bir Tawil. Every reputable travel agent we approached turned us down point-blank, citing the prevalence of bandit attacks in the desert. Thankfully, we were able to locate a disreputable travel agent, a large man with a taste for loud polo shirts who went by the name of Obai. Obai was actually not a travel agent at all, but rather a big-game hunter with a lucrative sideline in ambiguously licensed pick-up trucks. In exchange for most of our used banknotes, he offered to provide us with a jeep, a satellite phone, two tanks of water, and his nephew Gedo, who happened to be looking for work as a driver. In the absence of any alternative offers, we gratefully accepted.

Unlike Obai, who was a font of swashbuckling anecdotes and improbable tales of derring-do, Gedo turned out to be a more taciturn soul. He was a civil engineer who had previously done construction work on the colossal Merowe dam in northern Sudan, Africas largest hydropower project. On the day of our departure, he turned up wearing a baseball cap with Parental Advisory: Explicit Lyrics emblazoned across the front, and carrying a loaded gun. As we waved goodbye to Obai and began weaving our way through the capitals rush hour traffic, Omar and I set about explaining to Gedo the intricacies of our plan to transform Bir Tawil into an open-source state that would disrupt existing patterns of global power and privilege no mean feat, given that we didnt understand any of the intricacies ourselves. Gedo responded to this as he responded to everything: with a sage nod and a deliberate stroke of his stubble.

Im here to protect you, he told us solemnly, as we swung north on to the highway and left Khartoum behind us. Also, Ive never been on a holiday before, and this one sounds fun.

Bir Tawils unusual status wedged between the borders of two countries and yet claimed by neither is a byproduct of colonial machinations in north-east Africa, during an era of British control over Egypt and Egyptian influence on Sudan.

In 1899, government representatives from London and Cairo the latter nominally independent, but in reality the servants of a British protectorate put pen to paper on an agreement which established the shared dominion of Anglo-Egyptian Sudan. The treaty specified that, following 18 years of intense fighting between Egyptian and British forces on the one side and Mahdist rebels in Sudan on the other, Sudan would now become a British colony in all but name. Its northern border with Egypt was to run along the 22nd parallel, cutting a straight line through the Nubian desert right out to the ocean.

Three years later, however, another document was drawn up by the British. This one noted that a mountain named Bartazuga, just south of the 22nd parallel, was home to the nomadic Ababda tribe, which was considered to have stronger links with Egypt than Sudan. The document stipulated that henceforth this area should be administered by Egypt. Meanwhile, a much-larger triangle of land north of the 22nd parallel, named Halaib, abutting the Red Sea, was assigned to other tribes from the Beja people who are largely based in Sudan for grazing, and thus now came under Sudans jurisdiction. And that was that, for the next few decades at least. World wars came and went, regimes rose and fell, and those imaginary lines in the sand gathered dust in bureaucratic archives, of little concern to anyone on the ground.

Disputes only started in earnest when Sudan finally achieved independence in 1956. The new postcolonial government in Khartoum immediately declared that its national borders matched the tweaked boundaries stipulated in the second proclamation, making the Halaib triangle Sudanese. Egypt demurred, insisting that the latter document was concerned only with areas of temporary administrative jurisdiction and that sovereignty had been established in the earlier treaty. Under this logic, the real border stayed straight and the Halaib triangle remained Egyptian.

By the early 1990s, when a Canadian oil firm signalled its intention to begin exploration in Halaib and the prospect of substantial mineral wealth being found in the region gained momentum, the disagreement was no longer academic. Egypt sent military forces to reclaim Halaib from Sudan, and despite fierce protests from Khartoum which still considers Halaib to be Sudanese and even tried to organise voting there during the 2010 Sudanese general election it has remained under Cairos control ever since.

Our world is littered with contested borders. The geographers Alexander Diener and Joshua Hagen refer to the dashed lines on atlases as the scars of history. Compared with other divisions between countries that seem so solid and timeless when scored on a map, these squiggles enclaves, misshapen lumps and odd protrusions are a reminder of how messy and malleable the process of drawing up borders has always been.

What makes this particular border conflict unique, though, is not the tussle over the Halaib triangle itself, but rather the impact it has had on the smaller patch of land just south of the 22nd parallel around Bartazuga mountain, the area known as Bir Tawil.

Egypt and Sudans rival claims on Halaib both rest on documents that appear to assign responsibility for Bir Tawil to the other country. As a result, neither wants to assert any sovereignty over Bir Tawil, for to do so would be to renounce their rights to the larger and more lucrative territory. On Egyptian maps, Bir Tawil is shown as belonging to Sudan. On Sudanese maps, it appears as part of Egypt. In practice, Bir Tawil is widely believed to have the legal status of terra nullius nobodys land and there is nothing else quite like it on the planet.

Omar and I were not, it must be acknowledged, the first to discover this anomaly. If the internet is to be believed, Bir Tawil has in fact been claimed many times over by keyboard emperors whose virtual principalities and warring microstates exist only online. The Kingdom of the State of Bir Tawil boasts a national anthem by the late British jazz musician Acker Bilk. The Emirate of Bir Tawil traces its claim over the territory to, among other sources, the Quran, the British monarchy, the 1933 Montevideo Convention and the 1856 US Guano Islands Act. There is a Grand Dukedom of Bir Tawil, an Empire of Bir Tawil, a United Arab Republic of Bir Tawil and a United Lunar Emirate of Bir Tawil. The last of these has a homepage featuring a citizen application form, several self-help mantras, and stock photos of people doing yoga in a park.

From our rarefied vantage point at the back of Obais Toyota Hilux, it was easy to look down with disdain upon these cyber-squatting chancers. None of them had ever actually set foot in Bir Tawil, rendering their claims to sovereignty worthless. Few had truly grappled with Bir Tawils complex backstory, or of the bloodshed it was built upon (tens of thousands of Sudanese fighters and civilians died as a result of the Egyptian and British military assaults that ended in the establishment of Sudans northern borders and thus, ultimately, the creation of Bir Tawil). Granted, Omar and I knew little of the backstory either, but at least we had actually got to Sudan and were making, by our own estimation, a decent fist of finding out. We ate our energy bars, listened attentively to tales of Gedos love life, and scanned the road for clues. The first arrived nearly 200 miles north-east of Khartoum, about a third of the way up towards Bir Tawil, when we came across a city of iron and fire oozing kerosene into the desert. This was Atbara: home of Sudans railway system, and the engine room of its modern-day creation story.

Until very recently, the long history of Sudan has not been one of a single country or people: many different tribes, religions and political factions have competed for power and resources, across territories and borders that bear no relation to those marking out the states limits today. A lack of rigid, recognisable boundaries was used to help justify Europes violent scramble to occupy and annex land throughout Africa in the 19th century. Often, the first step taken by western colonisers was to map and border the territory they were seizing. Charting of land was usually a prelude to military invasion and resource extraction; during the British conquest of Sudan, Atbara was crucial to both.

Sudans contemporary railway system began life as a battering ram for the British to attack Khartoum. Trains carried not only weapons and troops but everyday provisions too, specified by Winston Churchill as the letters, newspapers, sausages, jam, whisky, soda water, and cigarettes which enable the Briton to conquer the world without discomfort. Atbara was the site where key rail lines intersected, and its importance grew rapidly after Londons grip on Sudan had been formalised in the 1899 Anglo-Egyptian treaty.

Everything that mattered, from cotton to gum, came through here, as did all the rolling stock needed to move and export it, Mohamed Ederes, a local railway storekeeper, told us. He walked us through his warehouse, down corridors stacked high with box after box of metal train parts and past giant leather-bound catalogues stuffed with handwritten notes. From here, he declared proudly, you reached the world.

Atbaras colonial origins are still etched into its modern-day layout. One half of the town, originally the preserve of expatriates, is low-rise and leafy; on the other side of the tracks, where native workers were made to live, accommodation is denser and taller. But just as Atbara was a vehicle for colonialism, so too was it the place in which a distinct sense of Sudanese nationhood began to develop.

As Sudans economy grew in the early 20th century, so did the railway industry, bringing thousands of migrant workers from disparate social and ethnic groups to the city. By the second world war, Atbara was famous not only for its carriage depots and loading sidings, but also for the nationalist literature and labour militancy of those who worked within them. Poets as well as workers leaders emerged out of the nascent trade union movement in the late 1940s, which held devastating strikes and helped shake the foundations of British rule. The same train lines that had once borne Churchills sausages and soda water were now deployed to deliver workers solidarity packages all over the country, during industrial action that ultimately brought the colonial economy to a halt. Within a decade, Sudan secured independence.

The next morning, as we drove on, Gedo grew quieter and the signs of human habitation became sparser. At Karima, a small town 150 miles further north, we came across a fleet of abandoned Nile steamers stranded on the river bank; below stairs there were metal plaques bearing the name of shipwrights from Portsmouth, Southampton and Glasgow, each companys handiwork now succumbing slowly to the elements. We clambered through cobwebbed cabins and across rotting sun decks, and then decided to scale the nearby Jebel Barkal Holy Mountain in Arabic where eagles tracked us warily from the sky. Omar maintained a running commentary on our progress, delivered as a flawless Herzog parody, and it proved so painful for all in earshot that the eagles began to dive-bomb us. We set off running, taking refuge among the mountains scattered ruins.

Jebel Barkal was once believed to be the home of Amun, king of gods and god of wind. Fragments of Amuns temple are still visible at the base of the cliffs. Over the past few millennia, Jebel Barkal has been the outermost limit of Egypts Pharaonic kingdoms, the centre of an autonomous Nubian region, and a vassal province of an empire headquartered thousands of miles away in Constantinople. In the modern era of defined borders and seemingly stable nation states, Bir Tawil seems an impossible anomaly. But standing over the jagged crevices of Jebel Barkal, looking out across a region that had been passed between so many different rulers, and formed part of so many different arrangements of power over land, our endpoint started to feel more familiar.

The following evening we camped at Abu Hamed, on the very edge of the desert. Beyond the ramshackle cafeterias that have sprung up to serve the artisanal gold-mining community sending shisha smoke and the noise of Egyptian soap operas spiralling up into the night Omar and I saw the outlines of large agricultural reclamation projects, silhouetted in the distance against a starry sky. Since 2008, when global food prices spiked, there has been a boom in what critics call land-grabbing: international investors and sovereign wealth funds snapping up leases on massive tracts of African territory in order to intensify the production of crops for export, and bringing such territory under the control of European, Asian and Gulf nations in the process. Arable land was the first to be targeted, but increasingly desert areas are also being fenced off and sold. Near Abu Hamed, Saudi Arabian companies have been greening the sand blanketing it in soil and water in an effort to make it fertile with worrying consequences for both the environment and local communities, some of whom have long asserted customary rights over the area.

It was not so long ago that the prophets of globalisation proclaimed the impending decline of the nation-state and the rise of a borderless world one modelled on the frictionless transactions of international finance, which pay no heed to state boundaries.

A resurgent populist nationalism and the refugee crisis that has stoked its flames has exposed such claims as premature, and investors depend more than ever on national governments to open up new terrains for speculation and accumulation, and to discipline citizens who dare to stand in the way. But there is no doubt that we now live in a world where the power of capital has profoundly disrupted old ideas about political authority inside national boundaries. All over the planet, the institutions that impact our lives most directly banks, buses, hospitals, schools, farms can now be sold off to the highest bidder and governed by the whims of a transnational financial elite. Where national borders once enclosed populations capable of practising collective sovereignty over their own resources, in the 21st century they look more and more like containers for an inventory of private assets, each waiting to be spliced, diced and traded around the world.

It was at Abu Hamed, while lying awake at night in a sleeping bag, nestled into a shallow depression in the sand, that I realised the closer we were getting to our destination, the more I understood what was so beguiling about it. Now that Bir Tawil was in sight, it had started to appear less like an aberration and more like a question: is there anything natural about how borders and power function in the world today?

In the end, there was no fanfare. On a hazy Tuesday afternoon, 40 hours since we left the road at Abu Hamed, 13 days since we touched down in Khartoum, and six months since the dotted lines of Bir Tawil first appeared before our eyes, Omar gave a shout from the back of the jeep. I checked our GPS coordinates on the satellite phone, and cross-referenced them with the map. Gedo, on being informed that we were now in Bir Tawil and outside of any countrys dominion, promptly took out his gun and fired off a volley of shots. We traipsed up a small hillock and wedged our somewhat forlorn flag into the rocks a yellow desert fox, set against a black circle and bordered by triangles of green and red then sat and gazed out at the horizon, tracing the rise and fall of distant mountains and following the curves of sunken valleys as they criss-crossed each other like veins through the sand. The sky and the ground both looked massive, and unending, and the warm stones around us crumbled in our hands. After a couple of hours, Gedo said that it was getting late, so we climbed back into the jeep and began the long journey home.

Well before our journey had ever begun, we had hoped albeit not particularly fervently that we could do something with it, something that mattered; that by striking out for a place this nebulous we could find a shortcut to social justice, two days drive from the nearest tap or telephone. In 800 square miles of desert, we thought that we could exploit the outlines of the bordered world in order to subvert it.

Jeremiah Heaton, beyond the kingdom for a princess schmaltz and the forthcoming Disney adaptation (he has sold film rights to his story for an undisclosed fee) seems albeit from an almost diametrically opposite philosophical outlook to be convinced of something similar. For him, the fantasy is a libertarian one, offering freedom not from the iniquities of capitalism but from the government interference that inhibits it. Just as we did, he wants to take advantage of a quirk in the system to defy it. When I spoke to Heaton, he told me with genuine enthusiasm that his country (not yet recognised by any other state or international body) would offer the worlds great innovators a place to develop their products unencumbered by taxes and regulation, a place where private enterprise faces no socially prescribed borders of its own. Big companies, he assured me, were scrambling to join his vision.

You would be surprised at the outreach that has occurred from the corporate level to me directly, Heaton insisted during our conversation. Its not been an issue of me having to go out and sell myself on this idea. A lot of these large corporations, they see market opportunities in what Im doing. He painted a picture of Bir Tawil one day playing host to daring scientific research, ground-breaking food-production facilities and alternative banking systems that work for the benefit of customers rather than CEOs. I asked him if he understood why some people found his plans, and the assumptions they rested on, highly dubious.

Theres that saying: if you were king for a day, what would you do differently? he replied. Think about that question yourself and apply it to your own country. Thats what Im doing, but on a much bigger scale. This is not colonialism; Im an individual, not a country, I havent taken land that belongs to any other country, and Im not extracting resources other than sunshine and sand. I am just one human being, trying to improve the condition of other human beings. I have the purest intentions in the world to make this planet a better place, and to try and criticise that just because Im a white person sitting on land in the middle of the Nubian desert He trailed off, and was silent for a moment. Well, he concluded, its really juvenile.

But if, by some miracle, Heaton ever did gain global recognition as the legitimate leader of an independent Bir Tawili state, would his pitch to corporations base yourself here to avoid paying taxes and escape the manacles of democratic oversight actually do anything to improve the condition of other human beings? Part of the allure of unclaimed spaces is their radical potential to offer a blank canvas but as Omar and I belatedly realised, nothing, and nowhere, starts from scratch. Any utopia founded on the basis of a concept terra nullius that has wreaked immense historical destruction, is built on rotten foundations.

In truth, no place is a dead zone, stopped in time and ripe for private capture least of all Bir Tawil, which translates as long well in Arabic and was clearly the site of considerable human activity in the past. Although it lacks any permanent dwellings today, this section of desert is still used by members of the Ababda and Bisharin tribes who carry goods, graze crops and make camp within the sands. (Not the least of our failures was that we did not manage to speak to any of the peoples who had passed through Bir Tawil before we arrived.) Their ties to the area may be based on traditional rather than written claims but Bir Tawil is not any more a no mans land than the territory once known as British East Africa, where terra nullius was repeatedly invoked in the early 20th century by both chartered companies and the British government that supported them to justify the appropriation of territory from indigenous people. I cannot admit that wandering tribes have a right to keep other and superior races out of large tracts, exclaimed the British commissioner, Sir Charles Eliot, at the time, merely because they have acquired the habit of straggling over far more land than they can utilise.

Bir Tawil is no terra nullius. But no mans lands or at least ambiguous spaces, where boundaries take odd turns and sovereignty gets scrambled are real and exist among us every day. Some endure at airports, and inside immigration detention centres, and in the pockets of economic deprivation where states have abandoned any responsibility for their citizens. Other no mans lands are carried around by refugees who are yet to be granted asylum, regardless of where they may be having fled failed states or countries which would deny them the rights of citizenship, they occupy a world of legal confusion at best, and outright exclusion at worst.

Perhaps that is why, as we switched off the camera and left Bir Tawil behind us, Omar and I felt a little let down. Or perhaps we shared a sense of anticlimax because we were faintly aware of something rumbling back home in Cairo, where millions of people were about to launch an epic fight against political and economic exclusion not by withdrawing to a no mans land but by confronting state authority head-on, in the streets. A week after our return to Egypt, the country erupted in revolution.

Borders are fluid things; they help define our identities, and yet so often we use our identities to push up against borders and redraw them. For now the boundaries that divide nation states remain, but their purpose is changing and the relationship they have to our own lives, and our own rights, is growing increasingly unstable. If Bir Tawil the preeminent ambiguous space is anything to those who live far from it, it is perhaps a reminder that no particular configuration of power and governance is immutable. As we drove silently, and semi-contentedly, back past the gold-foragers, and the ramshackle cafeteria, and the heavy machinery of the Saudi farm installations Gedo at the wheel, Omar asleep and me staring out at nothing I grasped what I had failed to grasp on that lazy night of beer drinking on Omars balcony. The last truly unclaimed land on earth is really an injunction: not for us to seek out the mythical territory where we can hide from the things that anger us, but to channel that anger instead towards reclaiming territory we already call our own.

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Welcome to the land that no country wants

Unitary Republic of Bir Tawil – MicroWiki

Bir Tawil, officialy The Unitary Republic of Bir Tawil or The Unitary Republic of Bi'r Tawl, is a nation in between Egypt and Sudan. It was founded on 27 January 2022. The Unitary Republic of Bir Tawil is an unrecognized self-declared state. The Bir Tawil region was previously left unclaimed.The reason the Bi'r Tawl region is unclaimed is due to both Egypt and Sudan claiming the Hala'ib Triangle, and claiming the Bir Tawil Triangle would negate their claim on the 'more valuable' Hala'ib Triangle. Bir Tawil attempts to stay neutral on the Hala'ib triangle dispute.

The Unitary Republic of Bir Tawil is a republic with elections every three years. Every three years the citizens vote for a Minister and a Vice-Minister. Also, every three years the citizens vote for the council members. There are nine roles in the council specializing in certain fields.

The name Bir Tawil (Arabic: , Romanized: Br awl) means tall water well in English. The Unitary Republic area of the name, shows our form of republic, a unitary republic.

Bir Tawil declared independence on 27 January 2022, however, Bir Tawil formed its government on 26 January and wrote its constitution on 28 January. On 27 January NURP (National Unitary Republican Party) was founded and was elected as the major party in the ministerial vote. Then on 2/3/22 the DSPBT (Democratic Socialist Party of Bir Tawil) was approved and formed. Bir Tawil's second Councillor was voted in unanimously after the DSPBT's formation. On March 10, 2022 a civil war was started by the Tawilian United Front. The Tawilian United Front (War) was started due to the election for Chief Councillor, the DSPBT and the CDLP lost the election and formed a rogue political movement and started a revolution that slowly is gaining support. On March 12 2022 the Russian Federation invaded Ukraine. This brought the nation to shock. The Minister stated this has brought our nation to shock. The Russian Federation will pay for their actions in Ukraine. Our nation will not stand with this threat to democracy, Slava Ukraini! After this invasion, Bir Tawil issued special postage stamps to support Ukraine and Democracy.

Bir Tawil's Ministry consists of a Minister and Vice-Minister which act as executives. The Minister's Job is to keep the laws constitutional and purposeful. The Minister also tends to the economy and makes sure the civilians are happy, healthy and makes sure they are safe. The Vice-Minister's job is to advise the Minister and keep the Council in check. The council is formed with eight Councillors and one Chief Councillor. Each Councillor has a special area of politics to make sure its needs are attended too. There are nine roles in the council:

Bir Tawil is a disarmed nation without active armed forces; however, Bir Tawil does have a border protection. The Bureau of Border Protection is split into three subdivisions, the Bir Tawil Border Security makes sure the nation is safe and protected from foreign invaders or external terroristic-like threats. The Customs and Border Protection Agency makes sure that foreign threats do not enter the nation. The Bir Tawil Domestic Threats Agency makes sure there are not threats inside Bir Tawil's borders.

Bir Tawil has no relations with any other nation of any sorts but is a member of a faction started and run by itself, named IUDSS (International United Democratic Sovereign States). The IUDSS has an election for the leading states every year (assuming there is more than a single state in the IUDSS). To get into the IUDSS the state must be:

1. Democratic 2. Have More than a one major political party3. Fill out an application to join the IUDSS where more requirements are stated (applications are not available for anything other than in person handouts as of now)

Bir Tawil is a small area located in the Sahara Desert. Bir Tawil consists of mostly sand and sandstone. The highest point is known as Jabal Tawil. The area is not claimed by either Egypt or Sudan making it unclaimed or, in other words "terra nullius".

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Unitary Republic of Bir Tawil - MicroWiki

AndersenTawil syndrome – Wikipedia

Rare autosomal dominant genetic disorder

Medical condition

AndersenTawil syndrome, also called Andersen syndrome and long QT syndrome 7, is a rare genetic disorder affecting several parts of the body. The three predominant features of AndersenTawil syndrome include disturbances of the electrical function of the heart characterised by an abnormality seen on an electrocardiogram (a long QT interval) and a tendency to abnormal heart rhythms, physical characteristics including low-set ears and a small lower jaw, and intermittent periods of muscle weakness known as hypokalaemic periodic paralysis.[1]

AndersenTawil syndrome is inherited in an autosomal dominant pattern. It is caused in most cases by a mutation in the KCNJ2 gene which encodes an ion channel that transports potassium out of cardiac muscle cells. The arrhythmias seen in the condition can be treated with flecainide or beta-blockers, but an implantable defibrillator may sometimes be required. Periodic paralysis can be treated with carbonic anhydrase inhibitors such as acetazolamide. The condition is very rare and is estimated to affect one person in every million. The three groups of features seen in this condition were first described in 1971 by Ellen Andersen, and significant contributions to its understanding were made by Rabi Tawil.

AndersenTawil Syndrome classically comprises three groups of features: abnormal electrical function of the heart, hypokalemic periodic paralysis, and characteristic physical features, although some of those affected will not exhibit all aspects of the condition.[2]

AndersenTawil syndrome affects the heart by prolonging the QT interval, a measure of how long it takes the heart to relax after each heart beat. This, as in other forms of long QT syndrome, can lead to abnormal heart rhythms such as ventricular ectopy or ventricular tachycardia causing palpitations.[2] The ventricular tachycardia seen in AndersenTawil syndrome often takes a form known as bidirectional ventricular tachycardia. The arrhythmias seen in association with the condition can cause sudden cardiac death, but the risk of this is lower than in other forms of long QT syndrome.[1]

The physical abnormalities associated with AndersenTawil syndrome typically affect the head, face, limbs and spine. Abnormalities of the head and face include an unusually small lower jaw (micrognathia), low-set ears, widely spaced eyes (hypertelorism), a broad forehead and nasal root, a high arched or cleft palate, and a long narrow head (scaphocephaly).[3] Abnormalities of the limbs and spine include an abnormal curvature of the fingers, particularly the fifth finger (clinodactyly), fused fingers or toes (syndactyly), short stature, and a curved spine (scoliosis).[3]

The third key feature of AndersenTawil syndrome is intermittent muscle weakness. This can last from seconds to minutes, but in some cases may last for days at a time. Weakness often occurs at times when the levels of potassium in the blood are lower than normal (hypokalaemia), and is referred to as hypokalaemic periodic paralysis. This weakness can however occur at times when potassium levels are normal, triggered by other factors including exercise, cold, or even menstruation.[3]

AndersenTawil syndrome is a genetic disorder which in the majority of cases is caused by mutations in the KCNJ2 gene. The condition is often inherited from a parent in an autosomal dominant manner, but may occur due to a new genetic mutation in the affected person.[3]

Two types of AndersenTawil syndrome have been described, distinguished by the genetic abnormality that is detected. Type 1 AndersenTawil, accounting for about 60% of cases, is caused by mutations in the KCNJ2 gene.[4] In type 2 AndersenTawil, accounting for about 40% of cases, a KCNJ2 mutation is not identified. Mutations in a related gene encoding a similar potassium ion channel, KCNJ5, have been identified in some of those with type 2 AndersenTawil, but in many cases a genetic mutation is not found.[1]

The protein made by the KCNJ2 gene forms an ion channel that transports potassium ions into muscle cells. This specific channel (the inward rectifier potassium channel Kir2.1) carries a potassium current known as IK1 which is responsible for setting the resting membrane potential of muscle cells and is therefore critical for maintaining the normal functions of skeletal and cardiac muscle.[3] Pathogenic mutations in the KCNJ2 gene alter the usual structure and function of potassium channels or prevent the channels from being inserted correctly into the cell membrane. Many mutations prevent a molecule called PIP2 from binding to the channels and effectively regulating their activity. These changes disrupt the flow of potassium ions, leading to the periodic paralysis and abnormal heart rhythms characteristic of AndersenTawil syndrome.[4]

AndersenTawil syndrome increases the risk of abnormal heart rhythms by disturbing the electrical signals that are used to coordinate individual heart cells. The genetic mutation disturbs an ion channel responsible for the flow of potassium, reducing the /K1 current. This prolongs of the cardiac action potential the characteristic pattern of voltage changes across the cell membrane that occur with each heart beat, and depolarises the resting membrane potential of cardiac and skeletal muscle cells.[3]

Cardiac and skeletal muscle cells, when relaxed, have fewer positively charged ions on the inner side of their cell membrane than on the outer side, referred to as their membranes being polarised.[5] The main ion current responsible for maintaining this polarity is /K1, and a decrease in this current leads to less polarity at rest, or a depolarised resting membrane potential. When these cells contract, positively charged ions such as sodium and calcium enter the cell through ion channels, depolarising or reversing this polarity. After a contraction has taken place, the cell restores its polarity (or repolarises) by allowing positively charged ions such as potassium to leave the cell, restoring the membrane to its relaxed, polarised state.[5] The genetic mutation found in those with AndersenTawil decreases the flow of potassium, slowing the rate of repolarisation which can be seen in individual cardiac muscle cells as a longer action potential and on the surface ECG as a prolonged QT interval.[3]

The prolonged action potentials can lead to arrhythmias through several potential mechanisms. The frequent ventricular ectopy and bidirectional VT typical of AndersenTawil syndrome are initiated by a triggering beat in the form of an afterdepolarisation. Early afterdepolarisations, occurring before the cell has fully repolarised, arise due to reactivation of calcium and sodium channels that would normally be inactivated until the next heartbeat is due.[6] Under the right conditions, reactivation of these currents can cause further depolarisation of the cell, facilitated by the sodium-calcium exchanger.[6] Early afterdepolarisations may occur as single events, but may occur repeatedly leading to multiple rapid activations of the cell.[6] Delayed afterdepolarisations, occurring after repolarisation has completed, arise from the spontaneous release of calcium from the intracellular calcium store known as the sarcoplasmic reticulum. This calcium release then leaves the cell through the sodium calcium exchanger in exchange for sodium, generating a net inward current and depolarising the cell membrane.[6] If this transient inward current is large enough, a premature action potential is triggered.

The muscle weakness seen in those with AndersenTawil syndrome arises from the depolarisation of the resting membrane potential caused by a decrease in /K1.[3] The depolarised resting membrane potential means that sodium channels which are responsible for initiating action potentials are unable to fully recover from inactivation, leading to a less excitable membrane and less forceful muscle contraction.[3]

The mechanisms underlying the skeletal abnormalities seen in AndersenTawil syndrome have not been fully explained. Possibilities include impaired function of osteoclasts, cells which regulate bone growth, or disruption of the bone morphogenetic protein signalling cascade.[3]

AndersenTawil syndrome is generally diagnosed based on symptoms, the findings on examination, and the results of an electrocardiogram.[3] Clinical diagnostic criteria have been proposed which suggest that a diagnosis can be made if two of the following four criteria are met: (1) periodic paralysis; (2) ventricular arrhythmias (frequent ventricular ectopic beats or ventricular tachycardia), a prolonged QT interval when corrected for rate, and/or a prominent U wave; (3) at least two of the following dysmorphic features: low-set ears, wide-set eyes, a small mandible, fifth-digit clinodactyly, and syndactyly; and (4) a family member with confirmed AndersenTawil syndrome.[3]

Genetic testing can be used to identify the specific mutation in an affected person, which if found can assist with screening family members.[3] Other investigations that may be helpful in making a diagnosis include ambulatory ECG monitoring to assess for arrhythmias, measurement of blood potassium levels at baseline and during periods of weakness, and measurement of thyroid function.[7]

The differential diagnosis for a prolonged QT interval includes other forms of long QT syndrome such as RomanoWard syndrome in which only the electrical activity of the heart is affected without involving any other organs; Jervell and Lange-Nielsen syndrome in which a prolonged QT interval is combined with congenital deafness; and Timothy syndrome in which a prolonged QT interval is combined with abnormalities in the structure of the heart, in addition to autism-spectrum disorder.[8] The frequent ventricular ectopy and bidirectional ventricular tachycardia seen in AndersenTawil syndrome can also occur in catecholaminergic polymorphic ventricular tachycardia.[2]

The intermittent weakness seen in AndersenTawil syndrome also occurs in other forms of periodic paralysis hypokalaemic periodic paralysis, hyperkalaemic periodic paralysis, and paramyotonia congenita.[7]

As a genetic condition, AndersenTawil syndrome cannot be cured. However, many of symptoms of AndersenTawil such as blackouts due to abnormal heart rhythms or periodic paralysis can be successfully treated with medication or implantable devices. The rarity of the condition means that many of these treatments are based on consensus opinion as there are too few patients to conduct adequately powered clinical trials.[3]

Medications should be avoided that further prolong the QT interval such as sotalol and amiodarone as these drugs can promote abnormal heart rhythms.[3] Lists of medications associated with prolongation of the QT interval can be found online.[9] Drugs which reduce blood levels of potassium such as diuretics like furosemide and bendroflumethiazide should also be avoided as these can worsen the tendency to periodic paralysis and arrhythmias.[3] Conversely, potassium-containing supplements to increase blood potassium levels may be helpful.[3] Very strenuous or competitive sport should be discouraged as these may increase the risk of arrhythmias, although gentle exercise should be encouraged.[8]

As in other forms of long QT syndrome which predispose those affected to dangerous heart rhythm disturbances, the risk of arrhythmias can be reduced by taking beta blockers such as propranolol that block the effects of adrenaline on the heart.[3] Other antiarrhythmic drugs such as flecainide and verapamil may also be helpful.[3] Those at highest risk of recurrent arrhythmias such as those who have already had a cardiac arrest may benefit from an implantable cardioverter defibrillator a small device implanted under the skin which can detect dangerous arrhythmias and automatically treat them with a small electric shock.[3]

Periodic paralysis may be improved by taking carbonic anhydrase inhibitors such as acetazolamide.[3]

AndersenTawil syndrome is very rare, and as of 2013 approximately 200 cases had been described in the medical literature.[3] The condition is estimated to affect one person in every 1,000,000.[3]

Although a description of the condition had probably been made by Klein in 1963,[3] AndersenTawil syndrome is named after Ellen Andersen who described the triad of symptoms in 1971,[10] and Rabi Tawil who made significant contributions to the understanding of the condition in 1994.[11][12]

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AndersenTawil syndrome - Wikipedia