War on narcotics – The Shillong Times

Editor,

Pockets of Shillong are witnessing a rise in drug-related crimes. In the past weeks the law enforcers conducted counter-narcotics programs using community-based intelligence which has worked wonders on a temporary scale but this is a long war which will test the mettle of governments now and later. In this game of interests the lines are blurred from traffickers to a porous border along the North Eastern corridor. What we have not witnessed is the rise of rival cartels backed by corrupt states similar to situations in Mexico or Honduras. Unemployment is a matter of grave concern as each year students are getting out of institutions with degrees but no jobs. Technically, the distribution channels of narcotics are gaining ground in cyberspace too.Legalisation and decriminalization have always been on the cards but whether they will be implemented in letter and spirit is a debatable matter. We cannot be swayed by the capital punishment in Singapore or the failed Plan Colombia to draw a roadmap for ourselves, but the answer lies deeper than the series Narcos. Antony Loewensteins Pills, Powder and Smoke (Inside the Bloody War on Drugs) weaves it beautifully on this powerful multi-billion dollar industry which will not yield submissively.

Yours etc.,

Christopher Gatphoh,

Via email

Editor,

Apropos the letter Plight of NEHU students by Wilbert Thangkhiew (ST, July 15, 2022) I wholeheartedly endorse the views of the author. Being a victim of the issues highlighted issues in Wilberts letter, its even more frustrating to realise that youre not the only person struggling but a part of a larger disgruntled group. NEHU has become a den of politics for personal vendetta and vested interests. Many Vice-Chancellors have come and gone and we, the indigenous people, who have had multiple generations graduating from this university, feel sorry to witness the gradual downfall of this once esteemed institution. From having professors under CBI scanner for taking bribes from research scholars in broad daylight, disruptive forces meddling with everyday affairs to officials guilty of dereliction of duty from time immemorial, it seems NEHU has come a full circle with the appointment of the current Vice Chancellor.The VC is always out of station and a simple task of issuing a bonafide certificate takes more than two weeks to process. Whenever someone tries to raise an important issue there is an acting VC in office with no responsibility. Perhaps, employees in NEHU have gone into retirement mode with the VC eternally being away from the helm of affairs. So, the question is, are all VCs expected to be in Delhi for the majority of their tenures? I believe hefty salary and facilities makes the man affluent enough to neglect his primary duty of serving the state and the nation through quality education. The grapevine is abuzz that the VC has constructed a new chamber for himself from taxpayers money while vehemently giving false assurances of improving hostel facilities amidst crunch for funds.The Tura Campus has received step-motherly treatment with false assurances time and again. The question to be asked is how did NEHU find itself in such a situation of giving a 15- day time frame to casual workers, 7- day time frame to Tura Campus and again 15- day time frame to the students to meet their demands which has lapsed a long time ago?I hence urge the Chief Minister, all stakeholders and particularly the Chief Rector- the Honble Governor to initiate an academic audit to draw a comparison of how many days the VC has been in station and the reasons for his travels out of state. This culture of having institutional leaders being a law unto themselves should be done away with once and for all. And still, if the VC does not understand, which seems very likely, we do have a popular English coaching institute- Avenues in Shillong.

Yours etc.,

Benny Shira,

Tura

Excerpt from:

War on narcotics - The Shillong Times

Whats Really Going on in Those Police Fentanyl Exposure Videos? – The New York Times

KCTV5, after receiving responses questioning its reporting, appended an editors note that did not mention the medical consensus on this question, noting instead that medical records showed the officer was treated for fentanyl exposure and that the D.E.A. had affirmed that its agents potential exposure to fentanyl puts their safety and health on the line.

Three or four decades ago, the American media found itself producing plenty of readily identifiable villains in the nations war on drugs. The Miami of the 1980s, for instance, became a high-intensity zone of armed conflict between cocaine traffickers and the government, an era that inspired countless stylized Hollywood action flicks about cops, drugs and cartel enemies. By the 1990s, local news increasingly entrenched in the business of covering crime sustained a national obsession with urban gangs, which were depicted as so well armed and lawless that a bipartisan consensus formed around cutting the police blank checks to combat them; departments across the country received billions of dollars worth of military-grade equipment, from flash-bang grenades and night-vision goggles to armored trucks, for use in executing even low-level drug warrants. Nightly news broadcasts portrayed both drug users and dealers as dangerous elements concentrated in poverty-blighted inner cities, yet always at risk of creeping into the middle-class viewers suburb.

Police officers on the front lines of todays drug war confront a very different landscape. The human misery of todays overdose crisis is largely hidden from view, and it is certainly not centered on the police; it is squarely borne by drug users and their loved ones. Every single hour of every single day, 12 Americans die from a fatal overdose, according to preliminary C.D.C. data a slow-motion disaster quietly playing out in banal locales like residential neighborhoods, gas-station bathrooms and strip-mall parking lots, in the smallest towns and the largest cities, across social and economic classes. Fatal overdoses occur largely among those who are using substances alone, with no one there to revive them with Narcan. Unlike the police officers, they dont hyperventilate and gasp for air. Instead, they slowly drift off, gradually stop breathing and never wake up again.

Todays astonishing overdose death toll comes not from gang violence or turf wars but from a ubiquitous market of cheap and potent synthetic drugs. And so it is in the drugs themselves that police officers now see grave danger, including to themselves. Last year, the San Diego County Sheriffs Department produced and released its own public-safety video featuring what Sheriff Bill Gore described as traumatic body-worn camera footage of an officers life-threatening fentanyl exposure footage that circulated through various media outlets despite the skepticism of health professionals. Its as though each of these videos seeks to identify the new villain, the shocking peril, in an era whose drug-war battlefields are too diffuse and mundane to capture the public imagination. Images of cinematic urban war zones and Uzi-toting gangsters have been replaced by the knowledge that drug use quietly pervades communities of all sorts. So fear attaches to something equally slippery: fentanyl particles lurking in the air, or even just a few specks on a police uniform, blamed for one officers overdose in Ohio. (According to local reporting, the officer was eventually terminated from the force for, among other reasons, gross misconduct.)

More:

Whats Really Going on in Those Police Fentanyl Exposure Videos? - The New York Times

NY To Begin Accepting Cannabis Applications From People Harmed By War On Drugs – The Fresh Toast

The New York cannabis industry plans to prioritize those whove been disproportionately impacted by the War on Drugs.

On Thursday, the citys cannabis regulators approved rules that make it possible to start accepting retail applications from injured parties.

RELATED: New Yorks Draft Conditional Retail Regulations Raise Practical Concerns

The regulations explain that, in order to qualify, applicants must have experience operating a qualifying business and must have faced a conviction for a drug-related offense before the state legalized marijuana. Applicants can also qualify for a conditional adult-use marijuana retail license if they have a close family member that was convicted with a drug-related offense.

While good intentioned, these regulations have been criticized in the past due to how limiting they might end up being. A person thats been impacted by the war on drugs may have had encounters with the law in the past, something that makes it difficult for them to also have experience managing and running a business.

New York legalized marijuana on March 31 2021, and has been working on how to implement it fairly and profitably over the past year. While its legal to consume marijuana and possess up to three ounces of cannabis, the sale remains illegal, a topic that has created some confusion in the state, especially since new businesses continue to appear in the form of trucks, pop ups and brick and mortar, taking advantage of the marijuana boom.

Responsible authorities have tried to control these businesses by sending out cease and desist letters while still trying to keep the police uninvolved.

RELATED: New York Senate Just Approved This Critical Marijuana Bill

Sale of untested products put lives at risk, said Tremain Wright, chair of New Yorks Cannabis Control Board. I implore these illegal store operators, and any other stores pretending to be legal operations, to stop selling cannabis products immediately.

Read more:

NY To Begin Accepting Cannabis Applications From People Harmed By War On Drugs - The Fresh Toast

How the right waged a 100-year war to conquer America and why it’s winning – Salon

In two blockbuster decisions, the U.S. Supreme Court throttled the power of government to regulate pollution (West Virginia v. EPA) and expanded the power of government to regulate women's reproductive lives (Dobbs v. Jackson). There is no contradiction in these two decisions. They continue a hundred years of right-wing support for private enterprise and control over women's autonomy.

The American right has held together as a political movement through its core commitment to conserving what it views as traditional Christian values and private enterprise. American conservative politics is not about limited government, states' rights, individual freedom or free markets. These are all dispensable ideas that the right has adjusted and readjusted to protect core principles. Conservatives have built their own versions of big government and carved out innumerable exceptions to free markets for tariffs, business subsidies, friendly regulations and pro-business interventions abroad. They have backed individual choice and states' rights, for example, on racial issues, but not on alcohol and drug use, pornography, contraception, abortion and same-sex marriage. In defense of core objectives, conservatives shifted from being isolationists before Pearl Harbor to aggressive warriors against communism and terrorism. They have abandoned protectionism for free trade, public education for private school vouchers, and deficit control for "supply-side" tax cuts.

Control over women's allegedly dangerous sexuality and autonomy grounds the moral appeal of conservative politics. In this view, a morally-ordered society requires a morally-ordered family, with clear lines of divinely ordained masculine authority and the containment within it of women's erotic allure. Salacious, non-motherly displays of female bodies, sex education in schools, abortion rights, easy divorces and the tolerance of homosexuality and other forms of "deviance" undercut the reproduction and orderly progress of civilization. Feminist demands since the 1920s to upset manly and womanly distinctions and erode patriarchy, through the right's lens, de-feminizes women and feminizes men, opening the family and the nation to conquest (rape) and subversion (seduction). The history of failed civilizations, conservative physicianArabella Kenealywrote in 1922, "shows one striking feature as having been common to most of these great decadences. In nearly every case, the dominance and [sexual] license of their women were conspicuous."

Conservative politics has had an enduring appeal to Americans seeking the clarity and comfort of absolute moral codes, clear standards of right and wrong, swift and certain penalties for transgressors and established lines of authority in public and family life. Ultimately conservatives have engaged in a struggle for control over American public life against a liberal tradition they have seen as not just wrong on issues, but sinful, un-American and corrosive of the institutions and traditions that made the nation great. To achieve their ambitious aims, conservatives had to stay disciplined, mobilize their resources and wage total war against liberals, with unconditional surrender as the only acceptable result.

During the 1920s, conservatives pioneered their programs for enforcing their vision of traditional values and protecting private enterprise, which endure today. Efforts to uphold the traditional family and control the licentiousness of women emerged in the 1920s, not just through the prohibition of alcohol but in lesser-known campaigns against sexual "deviance," "smut" and drugs, and in defense of conservative motherhood. In 1925, British historianA.F. Pollardcited the U.S. as "the rising hope of stern and unbending Tories." American laws, he said, "were not so much a means of change as a method of putting on record moral aspirations, a liturgy rather than legislation; and the statutebook was less the fiat of the State than a book of common prayer."

The erotically charged society of the 1920s led to fears that Americans, especially the young, were falling victim to deviant sexuality, such as oral sex and homosexuality, and to the scourge of venereal disease. After World War I,however, efforts to prevent venereal disease through education and the administration of chemical prophylaxis gave way to moral uplift and law enforcement. For moral reformers of the 1920s, preventative measures only encouraged prostitution and promiscuity.

Conservative answers to venereal disease involved the restoration of the supposed moral integrity of society and the rigorous prosecution of prostitutes and other sex offenders. Congress failed to renew wartime appropriations for controlling venereal disease, and state censorship boards banned as obscene sex-education films and other forms of anti-venereal propaganda. In 1926, the federal government eliminated federal aid to the states to prevent venereal disease, while state appropriations for this purpose declined.

After World War I, the Catholic Church crusaded worldwide for moral renewal. In 1920,Pope Benedict XVwarned that atrocities of war had led to "the diminution of conjugal fidelity and the diminution of respect for constituted authority. Licentious habits followed, even among young women." In 1930, his successorPope Pius XIissued 12 rules designed to assure that "feminine garb be based on modesty and their ornament be a defense of virtue." Catholic authorities joined by evangelical white Protestants promoted in the 1920s the censorship of books, plays, movies and artwork that displayed obscenity, nudity, drinking, sex outside of wedlock, suggestive dancing, drug use, homosexuality, prostitution and love between people of different races.

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In the 1920s, conservatives backed the closing of America's public drug treatment clinics and, as they did with venereal disease, adopted a moral and law enforcement approach to narcotics. Addicts had no recourse other than illegal sources of supply. For moral reformers, drug and alcohol use undermined the family and threatened the purity of American women. Even more than drink, however, enslavement to narcotics was understood to undercut discipline, self-mastery and the free will needed to follow a godly life.Richard P. Hobson, head of the International Narcotic Education Association, charged that civilization was "in the midst of a life and death struggle with the deadliest foe that has ever menaced its future." Narcotics threatened "the perpetuation of civilization, the destiny of the world, and the future of the human race." In 1929, Congress began the national war on drugs by establishing a Federal Bureau of Narcotics to enforce the drug laws.

Conservative women drew on a maternalist ideology that affirmed inherent differences between the sexes and women's unique role in rearing children as healthy, moral and productive citizens. Conservative maternalists urged women of the New Era not to slip the bonds of men and custom but to reclaim their motherly responsibilities to rear courageous sons and domesticated daughters. They opposed reforms that confused sex roles, weakened families or substituted state paternalism for parental responsibility.

Conservative women warned against radicals who would rip children from the home and rear them in nurseries run by the state. The radicals would end sexual restraint and manly competition. They would feminize men and coerce women into "unnatural" masculine roles through forced work and conscription. Conservative women found dangerous sex-role reversals in women who embraced the unisex hedonism of the times: short skirts and bathing suits, bobbed hair, drinking, smoking, vigorous sports, necking and petting, and sensual music and dancing. Patriotic mothers would uphold family morals and shun the competitive male spheres of business, politics and war. Like women of Sparta, they would raise patriotic sons ready to risk their lives for the common defense. This view of women and their place in society was represented in such 1920s organizations as the Women's Auxiliary of the Ku Klux Klan, the Daughters of the American Revolution, the General Federation of Women's Clubs, the American Legion Auxiliary and the Daughters of 1812.

Women of the right mobilized against the first federal welfare measure, the Sheppard Towner Bill of 1921, which provided aid to the states for the health care of mothers and infants. They argued that the law would weaken families, undercut traditional values and advance paternalistic government. In the Sheppard-Towner fight, wrote editor Mary Kilbreth of the conservative publication Woman Patriot, "we have with us as allies the Constitution, and all the institutions on which 'Western civilization is based.'"

The right's pro-business policies included the anti-government initiatives of deregulation and tax cuts. Yet they also turned to government for protective tariffs, support for foreign trade and investment, controls over strikes and labor organizing, and pro-business regulations. Our goal is "putting government behind rather than in business,"Secretary of Commerce Herbert Hooversaid in 1924. In 1926, under Hoover's guidance, the Republican Congress stabilized the struggling airline and railroad industries with the Air Commerce Act and the Railway Act. On the seas, Congress extended subsidies to shipbuilders and operators in the Merchant Marine Act of 1928. To impose order on the broadcast spectrum, Congress established a Federal Radio Commission in 1927 and let broadcasters keep or sell their existing frequencies and block competitors from sharing airtime. Republican presidents appointed pro-business jurists to regulatory agencies and the federal courts.

Support for profit-seeking enterprise may contradict the right's emphasis on moral probity. However, conservatives linked private enterprise to stable, traditional families that nurtured the virtues of thrift, sobriety, self-reliance, honor and diligence. Even as Americans evolved from savers and craftsmen to producers and consumers, conservatives sustained the linkage between family virtue and enterprise. "The whole fabric of Business rests upon these moral forces," wrote journalistEdward Bokin 1926. Cultural warfare, in turn, gave the right a mass base and a passion that economic conservatism lacks. By uniting traditional Christian values and enterprise, conservatives claim to have protected Americans' pocketbooks and saved their souls.

Cultural and business conservatism converged forcefully again when the right regrouped in the 1970s. Conservatives then put a positive spin on their cultural prohibitionism. They weren't just against sinners and feminists; they were the "pro-family" and "pro-life" champions of wholesome "family values." Still, defense of the family meant battling the Equal Rights Amendment, abortion, pornography, gay rights and gun control. Phyllis Schlafly, the prime mover of the pro-family agenda, described "the family as the basic unit of society, with certain rights and responsibilities, including the right to insist that the schools permit voluntary prayer and teach the 'fourth 'R' (right and wrong) according to the precepts of the Holy Scriptures." At a well-attended "Pro-Family Rally" that upstaged the feminist 1977 "International Year of the Woman" gathering in Houston, she warned that feminists were "going to drive the homemaker out of the home. They want to relieve mothers of the menial task of taking care of their babies. They want to put them in the coal mines and have them digging ditches." The ERA would "only benefit homosexuals. The American women do not want ERA, abortion, lesbian rights, and they do not want childcare in the hands of government."

In 1971, corporate lawyer Lewis Powell issued a call to arms by conservatives shortly before his appointment to the U.S. Supreme Court. The "Powell Memo"guided the rebuilding of business conservatism and the presidency of Ronald Reagan. He warned that new regulations that cut across industry to limit pollution, control energy production, advance minority and consumer rights and protect worker health and safety threatened the survival of private enterprise. Powell insisted that conservatives, aided by the financial might of business, should not have "the slightest hesitation to press vigorously in all political arenas for support of the enterprise system. Nor should there be reluctance to penalize politically those who oppose it." Conservatives must aggressively capture the centers of power that shaped policy and public opinion: the political parties, the academy, the media, the courts and popular culture.

Consistent with the reformulation of cultural issues, conservatives in the 1970s put a positive spin on their pro-business policies, labeling them "supply-side economics." Entrepreneurs would create a new era of American abundance if they were free to innovate without penalty or control. They would produce enough goods and services to cure inflation, accelerate government revenue growth and reduce the deficit. Supply-side advocates promised that their bonanza to business would flow down or "trickle down," as critics charged to the lower strata because employment and wages would boom.

After his transformation election in 1980, President Ronald Reagan turned the supply-side dream into reality. His conservative economic policies rested on reducing tax liabilities for corporations and the wealthy, relieving businesses of civil rights, environmental, and economic regulations, cutting social spending and curbing the power of labor unions. It was a blueprint that the right would follow through today.

The history of the modern American conservative movement demonstrates that the Dobbs and EPA decisions are not aberrations. In fact, they realize priorities that the right has pursued since the 1920s. The only change is a right-wing grip on the Supreme Court that is unprecedented in modern American history. The court will likely extend its curtailment of air pollution regulation to water pollution in the upcoming case ofSackett v. EPA. And despite surface disagreement from other justices, it is also likely to follow Justice Clarence Thomas' call for reconsidering the rights to contraception, private sexual encounters and same-sex marriage. Given the right's quest for absolute power, it would not be surprising if the court then grants state legislatures controlled by Republicans in key swing states exclusive control over federal elections.

Read more

on the far right's assault on America

Excerpt from:

How the right waged a 100-year war to conquer America and why it's winning - Salon

DeLucas 5 Picks: Pink and Margo Price protest songs, plus Nightlands and music of The Bear – The Philadelphia Inquirer

1. Pink, Irrelevant. One day last week Pink tweeted: Woke up. Got heated. Wrote song. Coming soon.

The song that the Doylestown native born Alecia Moore penned and posted handwritten lyrics to is Irrelevant, an emphatic protest song, a rallying cry of defiance in which the singer refuses to be defined by others and works herself up into a righteous rage.

The collaborative effort with songwriter-producer Ian Fitchuk is clearly inspired by the recent Supreme Court decision to overturn Roe v. Wade, but is ready made to fit all kinds of protests.

It strategically evokes both The Whos The Kids Are Alright and Cyndi Laupers Girls Just Wanna Have Fun, which was written by the late Philadelphia singer Robert Hazard. Girls just wanna have rights, she sings. So why do we have to fight?

In a statement, Pink wrote: As a woman with an opinion and the fearlessness to voice that opinion, it gets very tiring when the only retort is to tell me how irrelevant I am. I am relevant because I exist, and because I am a human being. No one is irrelevant. And no one can take away my voice. Proceeds from sales of the song go to Michelle Obamas voting initiative When We All Vote.

2. Nightlands, Moonshine. Besides playing with The War On Drugs you know, the Philly band that opened for the Rolling Stones in London last month Dave Hartley makes music as Nightlands, a project that leans toward the ethereal, with spacious synth-based songs and vocals that reach skyward.

Moonshine is the first Nightlands album since 2017s I Can Feel The Night Around Me, and its contemplative nature is in part the result of the musicians move from Philadelphia to Asheville, N.C., where Hartley, a new parent, worked in isolation during the pandemic in a studio in a barn outside his century-old house.

Lots of Philly musicians make contributions to New Age-tinged tracks like No Kiss For the Lonely, however, including Eric Slick, Michael Kiley, and Jessie Hale Moore, plus Hartleys bandmates Charlie Hall, Eliza Hardy Jones, and Anthony LaMarca. The War On Drugs play the XPoNential Music Festival with Patti Smith on Sept. 16.

3. Margo Price featuring Mavis Staples and Adia Victoria, Fight To Make It. Last September when Margo Price played the Mann Center with Willie Nelsons Outlaw Music Tour, she debuted a cover of Lesley Gores You Dont Own Me in protest after Texas passed restrictive antiabortion legislation that month.

Now, Price has teamed with gospel great Mavis Staples and blues and Americana songwriter Adia Victoria to release this rockin country fight song that she has said was originally inspired by Amelia Earhart and Rosa Parks.

Along with Irrelevant, its one of what will surely be many protest songs released in the coming months. In a statement, Price said: Every day I see more of our rights stripped away in America. The right to reproductive health in this country has become a luxury for the wealthy . Black women in particular experience maternal mortality at a rate two to three times higher than white women.

Proceeds from Bandcamp sales of the song benefit Noise for Now, which connects artists with grassroots organizations that work in reproductive justice, including abortion access. Prices memoir Maybe Well Make It is due from University of Texas Press in October.

Don McCloskey. Bucks County born Don McCloskey is celebrating the release of The Chaos & the Beauty, a 10-song collection recorded in Brooklyn with Philly expats Devin Greenwood and Ali Wadsworth and guitarist Ross Bellinoit and released on his own Lemon Hill Records label.

The St. Joes Prep grad has a varied history: He wrote Unstoppable, the Phillies anthem that was played at Citizens Bank Park during the teams (long ago) 2009 World Series run, hes toured with Wu-Tang Clan rapper Raekwon and last Christmas he released a terrific reworked version of O Holy Night.

On Friday, he was set to play Ardmore Music Hall with Philly songwriter Chris Kasper, whose 2017 song City By The Sea is a Jersey Shore snapshot of Ventnor before it went bougie. This show has now been postponed because of COVID and will be rescheduled for the fall. ardmoremusichall.com.

The music of The Bear. The highly bingeable series about a hotshot chef who comes home to Chicago to run his family sandwich shop, that stars Jeremy Allen White, has a serious verisimilitude quotient in its authentic depiction of in-the-kitchen restaurant culture.

But the FX on Hulu series created by Christopher Storer also has something else going for it: a top notch, consistently surprising but not show-offy soundtrack put together by Storer and his music supervisor partner Josh Senior. Theres not too much music forced on the viewer as is often the case with prestige TV productions. Instead, its used sparingly, and often packs an emotional punch, whether its Counting Crowes Have You Seen Me Lately? or John Cougar Mellencamps Check It Out.

The shows Windy City identity comes through with Wilcos Via Chicago (and also Impossible Germany) and also Sufjan Stevens Chicago, though theres no sign of Sinatras My Kind of Town in the first season. But theres also lots of not-trendy far-flung acts, like Swedish hard core band Refused and perfectly fitting instrumental rock from Staten Island ensemble The Budos Band. Last week the show was renewed for a second season.

Original post:

DeLucas 5 Picks: Pink and Margo Price protest songs, plus Nightlands and music of The Bear - The Philadelphia Inquirer

Katy J Pearson : Sound of the Morning – Treble – Treble

It wasnt so long ago that music fans and critics openly ragged on adult contemporary as a rite of passage. The entire genre allegedly comprised treacly pablum and tender feelings designed exclusively for moms in minivans. An entire generation rejected those sounds, preferring songs that expressed emotions with heart-on-the-sleeve intensityno matter the genre.However, the soft rock of the 70s and 80s has recently experienced a slight resurgence. Artists such as Kevin Morby, Father John Misty, and The War on Drugs have built entire careers on updating and reinventing the music of acts such as Bread or Boz Scaggs. A generation of music fans that didnt experience it the first time now adore acts that embrace nuance, discomfort, and malleability. By taking slightly more care in how they express emotions, these musicians can hone greater songwriting acumen, production flairs, and compositional skill.

This is the environment into which Katy J Pearson strides with confidence. On her new album, Sound of the Morning, she delivers delightfully quirky singer-songwriter fare matched with upbeat pop-rock arrangements that would have been a perfect fit for 70s AM radio. Released on Heavenly Recordings, this 11-song project combines the chill vibes of Laurel Canyon with the sentimentality of 80s pop radio to delightful results. Its as if Joni Mitchell, Patty Griffin, and Destroyer collaborated across the decades to create thoughtful, yet catchy folk tunes.

It all starts with Pearsons expressive vocal range. Sitting comfortably in a high alto, she can both dip down low and reach for the heights as a song demands, complete with the rare break to seal the deal. She also displays a deft lyricism about a variety of grownup ideas and motifs including romantic misunderstandings, anxiety about relationships, and making sense of love, as well as feeling stuck in a dead-end situation and needing to grow so she can find a way out.

Despite this being a solo project, the album is rich with full-band arrangements. The production is bright and clear, allowing space for each instrument and vocal in the mix. Its also easy to become enamored with the superb musicianship in that the songs feel both light and substantivethe players are in sync, which means everything is intentional and nothing is overwrought. Crisp drums, warm guitars, lovely horns, and intricate piano phrasings flow together to create pristine arrangements packed with delicate flourishes.

Talk Over Town reeks with a delicious War On Drugs aesthetic, including spacey guitars, echoing vocals, and driving drums. The chorus erupts into a rich crescendo as Katy asks a simple question: Can you show me something Im missing? Is it something I can live without? On The Riverhead, the tempo slows down slightly, evoking a steady stroll between lovers as they walk around the banks of a lake in a park. The mood and lyrics call to mind a serious relationship about the future couched in pleasant memories of the past.

With Float, the tone takes a melancholy turn, as Pearson openly questions the long-term viability of a relationship. She plaintively sings about wandering the halls of their home, looking at pictures on the walls, and getting tired of pretending that her heart is fully committed. Game of Cards channels Fleetwood Mac by first fusing loping verses to a caustic chorus and then comparing a late-night chat with a partner to a high-stakes hand of poker. The album closes with the luscious Willows Song, a tune that features effervescent guitars, supple drumming, creeping string-centric synths, and well-timed horn bleats. Its a jaunty minor key affair that serves as both a mission statement for the project as well as a farewell note to the tumultuous relationships shes chronicled.

Sound of the Morning represents a profound progression in the career trajectory of Katy J Pearson. Like her musical forebears, she couches heavy feelings in immaculate, danceable pop grooves. The chord progressions seem familiar, but she turns them inside-out with artful aplomb so that listeners feel comfortable but never bored. Moreover, the sublime pacing to the track listing allows for terrific control of the emotional ebbs and flows. Pearson also knows how to express strong, yet realistic emotions with a matter-of-fact tone that belies her relative youth. Shes unafraid to face tough situations, preferring to persevere even if the journey isnt easy or the resolution very clean.

Label: Heavenly

Year: 2022

Similar Albums:

Originally posted here:

Katy J Pearson : Sound of the Morning - Treble - Treble

Woody Harrelson’s weed store reviewed: Into The Woods – Leafly

Reviewed The Woods WeHo

8271 Santa Monica BlvdWest Hollywood, CA

http://www.thewoodsweho.com

When an A-List actor like Woody Harrelson opens up a weed dispensary in a posh part of Los Angeles, you gotta go scope it out.

Were here to report back that the rustic, outdoorsy, The Woods champions artisanal, craft sungrown flower to locals in each price bracket. Its kind of the perfect fit for Harrelson, who has spent decades advocating weed legalization, criminal justice reform, and environmentalism. Humboldt hippies helped make California cannabis the best in the world. The Woods hopes LA folks will pay fair-trade prices to see these farmers survive the high taxes and red tape of legal weed.

Opened May 16 just off Melrose Avenue in the northern part of LA, The Woods is a project of Harrelson and the owner of the Erba dispensary chain.

Harrelson has supported weed law reform since at least 1996 when he got arrested for symbolically planting hemp in Texas. Cannabis went legal in California in 2016, and stores opened in 2018. Four years later, Harrelsons team converted an interior design store into a chic sungrown boutique that embodies the actors values.

Walking up to the store you are greeted by a concrete horse next to a large, intimidatingly ornate wooden door. The shop has kept many of the pieces of its former resident, hence the horse. Its bougie. This is West Hollywood, people.

Walking inside, the store manages to give more of a high-end furniture store feel rather than a dispensary. But details throughout invite inspection and browsing. Thats not typical for dispensaries that often hide product behind the counter and have limited informational resources.

The Woods has plenty of plant life throughout and is abundantly lit by a skylight, so it has a fresh, open feel.

The abundance of houseplants creates a fresh, herbal smell in the air. Absent birds, you instead hear the chirping of local passersby, since the large front door stays invitingly propped open.

Display cases all throughout the space show off brands and their products for perusal. Certain cases focus on categories like edibles, or pre-rolls. The clienteles favorite? Staff said edibles.

You can also buy an entire walls worth of award-winners from the worlds largest outdoor pot contest The Emerald Cup. The awards show took place for the first time in Hollywood this year and coincided with the opening of The Woods. Several awardees of the Emerald Cup donated their trophy to the display in The Woods. The display encourages shoppers to buy organic, sun-grown cannabis and to support the legacy farmers in the state.

Support Your Local Weed Farmer, the merch reads. On the wallframed, historic photos of cannabis farms from times past. A mural painted by a local artist covers the back wall and carries through the long hallway that will eventually lead to a smoking lounge. In the hallway, a gallery of NFT art by people imprisoned for weed cycles through on digital screens.

In one corner, you can sit down and look into a dozen little branded, weed farm dioramas. Its not the easiest display to browse, but it does encourage close inspection.

The chill vibes continued with the friendly budtenders wholl explain sun-grown organic cannabis benefits, the impacts of the War on Drugs, or the plight of legacy farmers in todays market.

The spacious store fosters browsing, with a decent-sized, well-curated selection. We saw 155 flowers on the menu. Los Angelenos are hooked on indoor flavors, and outdoor has a tough time penetrating the concrete jungle. The Woods stands out with Emerald Triangle brands not usually available this far south:

Woody also made concessions to LAs indoor exotic pot culture. We see tasty new flavors from:

Typically, you can expect lower prices on outdoor weed, and eighths of outs top out at $41 plus taxes at The Woods. Better quality weed should be worth more, The Woods believes, and consequently, some of their outdoor prices rival indoor.

In the future, the store will be one of a cluster of related businesses: a bar, a smoking lounge, and a dispensary. Each will have separate entrances and requirements, and it sounds like the bar and lounge will be very upscale.

I admit Im not the typical client of a store like The Woods. I prefer a dispensary connected to a different facet of LA culturethe Backpack Boyz, Dr. Greenthumbs, Cookies, Sherbinskis, and Greenwolfs of LA. But Woodys chic Woods gives WeHoans the chance to put their money where their values liestarting with sungrown, organic top-shelf from small, legacy NorCal hippies.

Dan Wilson

Dan Wilson is an independent pot journalist based in Los Angeles. Wilson is the founding Editor of Visit Hollyweed, California's cannabis community newspaper. His Los Angeles Dispensary Guidebook was published in April.

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Woody Harrelson's weed store reviewed: Into The Woods - Leafly

Viewpoint: Is anti-biotechnology New Zealand ready to embrace gene drives to control wasps, possums and other predator pests? – Genetic Literacy…

The once-forbidden concept of gene editing for predator control is back on the table after two projects received Government funding.

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Last month, the crown entity responsible for pest control, Predator Free 2050, announced investment of $6.7 million into research projects, including $2.25m to investigate whether recent overseas advances in producing mice of only one sex could be adapted for rats, and $200,000 to explore stoat breeding genetics, and whether that could be used for control.

In November, it announced $300,000 in funding towards research that could help eradicate possums by spreading genes that reduced fitness, resulting in gradual population decline.

He admitted pest control was not the area in which hed first expected to see progress; there were opportunities for medicine and climate resilience, too.

There was a gap between what was researched, and what was developed for commercial use.

We know that New Zealand is one of the best countries at generating knowledge, Peters said. But when it comes to developing that, and getting some return, were terrible.

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Viewpoint: Is anti-biotechnology New Zealand ready to embrace gene drives to control wasps, possums and other predator pests? - Genetic Literacy...

Orion Biotechnology and Peptilogics Enter Strategic Research Collaboration to Enable AI-Driven Drug Discovery Against Undrugged GPCR Target -…

Ottawa, Canada & Pittsburgh, USA, July 12, 2022 (GLOBE NEWSWIRE) -- Orion Biotechnology Canada Ltd, a drug discovery company targeting previously undruggable G Protein-Coupled Receptors (GPCRs), and Peptilogics, a biotech company engineering peptide therapeutics by combining computation and biology to improve the treatment landscape for patients with life-threatening diseases, announced today that they have entered a research and development collaboration to leverage AI for drug discovery against an undrugged GPCR target.

The collaboration will combine the capabilities of Peptilogics AI platform (NautilusTM) with Orion Biotechnologys proprietary drug discovery platform. The companies will leverage expertise in peptide design and engineering to drive drug discovery against an undrugged peptidergic GPCR linked to highly prevalent, life-threatening diseases.

Peptilogics Nautilus platform enables in silico predictive peptide design across diverse targets to efficiently access new functional chemical space and custom design therapeutics. Additionally, Peptilogics supercomputer accelerates model development and prediction and evaluation of peptide sequences, to produce higher-quality hits with greater chance of success. Synergistically, Orion Biotechnologys platform explores receptor-ligand shape space using proprietary multiplex synthesis technology to generate precision-engineered peptides with enhanced potency and tailored signaling activity. Orions platform generates data matrices for AI-assisted lead optimization, offering one of the fastest drug discovery and development solutions to target peptidergic GPCRs.

On the announcement of this collaboration, Dr. Oliver Hartley, VP Drug Discovery at Orion Biotechnology commented We are pleased to be partnering with Peptilogics to push the boundaries of receptor pharmacology and AI computing to accelerate innovation for improved patient outcomes. An AI-driven paradigm shift is happening in drug discovery, and Orion is pleased to be at the forefront of applying AI to the highly valuable space around GPCRs. The ideal fit between Orions platform and unique knowledge of receptor-ligand interactions with Peptilogics machine learning models will position us to make AI-driven GPCR drug discovery a reality.

Using Peptilogics Nautilus platform, we combine proprietary deep generative models, predictive models, and biophysical simulation to design multiparameter-optimized peptides that have the potential to address historically challenging and novel drug targets. Our AI algorithms enable efficient navigation of the vast peptide design space, allowing us to uncover molecules that may not be discovered through traditional screening, said Nicholas Nystrom, Ph.D., Chief Technology Officer of Peptilogics. We are excited to partner with Orion Biotechnology for their deep GPCR expertise. By combining the strengths of Peptilogics Nautilus AI-driven peptide design platform and Orions GPCR platform, we aim to reduce the risk, time, and cost for drug design.

About Orion Biotechnology

Orion Biotechnology Canada Ltd. is unlocking the therapeutic potential of previously undruggable G Protein-Coupled Receptors (GPCRs). Orions world-renowned experts in GPCR pharmacology and peptide/protein engineering leverage Orions proprietary drug discovery platform to rapidly and efficiently advance a diversified portfolio of precision engineered GPCR-targeted therapeutic candidates for the treatment of cancer and other serious diseases. To learn more, follow the company on LinkedIn or visit https://orionbiotechnology.com/.

About Peptilogics

Peptilogics engineers peptide therapeutic candidates to radically improve the treatment landscape for patients with life-threatening diseases. Through biological and pharmaceutical expertise, novel artificial intelligence algorithms, and purpose-built super-computing, Peptilogics is advancing an extensive therapeutic pipeline and accelerating discovery efforts at a pace and scale that was previously impossible. Peptilogics is backed by visionary investors in life science and technology including Peter Thiel, Presight Capital, Founders Fund, CARB-X, and Cystic Fibrosis Foundation. For more information about Peptilogics, visitwww.peptilogics.comor follow the company on Twitter and LinkedIn.

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Orion Biotechnology and Peptilogics Enter Strategic Research Collaboration to Enable AI-Driven Drug Discovery Against Undrugged GPCR Target -...

Demand For COVID-19 Saliva-Based Detection Kits Experienced Significant Growth, With An Estimated Market Value Of Around US$ 1.6 Bn; States Fact.MR -…

High Prevalence Of COVID 19, Growing Use Of Point-Of-Care Testing, And Rising Acceptance And Awareness Of Coronavirus Treatment Are Factors Attributed To The Growth Of The Market In The Country.

Rising awareness of home-based testing of SARS COV-2 infection and adoption of saliva-based detection as a feasible specimen are expected to drive market growth over the decade, says a Fact.MR analyst.

Fact.MR A Market Research and Competitive Intelligence Provider: The global COVID-19 saliva-based detection kits market was valued at US$ 1.4 Bn in 2020, with demand expected to decline at a CAGR of -2.8% over the forecast period (2021-2031).

COVID-19 is a severe and infectious disease, with diagnosis at the initial stage playing a significant role in stopping the further increase of cases. At present, the old method of sampling, i.e., nasopharyngeal swab is majorly used for testing. However, the emerging technique of saliva-based testing is a promising alternative for COVID-19 diagnosis.

When patients need to get urgent care for more critical flu-like symptoms, physicians need to perform diagnostic tests as soon as possible. To meet this requirement, test kits should be available at cheaper costs, easy to handle, rapid, and equipment-free. This creates an opportunity for market players to come up with innovative devices to fulfil the requirements of patients and physicians in the future.

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Key Takeaways from Market Study

Due to rising approvals of COVID-19 test kits that are convenient and simple to use, manufacturers are aiming to introduce new products in the market and get them approved.

For Instance, in July 2021, Nalagenetics and Nusantics obtained regulatory approval to launch PCR test kits to detect COVID-19 from saliva samples. These kits will function as alternatives to nasal and throat swab tests.

Leading players are focusing on advancements in in-vitro diagnostic procedures with rapid testing. These advancements are expected to gain popularity and generate high revenue in the market.

For instance, in April 2021, Therma Bright Inc. announced that it had received CE approval from an EU-competent authority of Belgium for its AcuVid COVID-19 rapid antigen saliva test.

To Gain In-Depth Insights on COVID-19 Saliva-Based Detection Kits Market, Request Methodology at

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Key Insights Covered in COVID-19 Saliva-based Detection Kits Industry Survey:

Market Developments:

The global market is set to expand due to rise in awareness of early detection of COVID-19 infection. Leading industry players are set to focus on research & development so that they can come up with unique products to strengthen their product portfolios.

In Aug 2020, Lenexa received FDA approval for a saliva-based COVID-19 test.

In April 2021, Qiagen launched artus Prep&Amp as a CE-Marked SARS-CoV-2 test.

Some of the leading players in the market include Thermo Fisher Scientific Inc, Qiagen NV, ACON Laboratories Inc., Assure Tech (Hangzhou) Co. Ltd., Takara Bio Inc., Nantong Diagnose Biotechnology Co., Ltd, KYODO INTERNATIONAL INC., Arcis Biotechnology Limited, GeneProof, Abacus ALS, Hologic Inc, Vitagene, Therma Bright Inc, Zymo Research Corporation, and Salimetrics.

Key Segments Covered in COVID-19 Saliva-based Detection Kits Industry Research

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Fact.MR brings a comprehensive research report on forecasted revenue growth at global, regional, and country levels that provides an analysis of the latest industry trends in each of the sub-segments from 2020 to 2031.

The global COVID-19 saliva-based detection kits market is segmented in detail to cover every aspect of the market and present a complete market intelligence approach to the reader. The study provides compelling insights based on product, technology, application, and end user, across seven main regions of the world.

Fact.MRs Domain Knowledge in Healthcare

Our healthcare consulting team guides organizations at each step of their business strategy by helping you understand how the latest influencers account for operational and strategic transformation in the healthcare sector. Our expertise in recognizing the challenges and trends impacting the global healthcare industry provides indispensable insights and support - encasing a strategic perspective that helps you identify critical issues and devise appropriate solutions.

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Demand For COVID-19 Saliva-Based Detection Kits Experienced Significant Growth, With An Estimated Market Value Of Around US$ 1.6 Bn; States Fact.MR -...

Zurcher Kantonalbank Zurich Cantonalbank Buys 1657 Shares of Cerevel Therapeutics Holdings, Inc. (NASDAQ:CERE) – Defense World

Zurcher Kantonalbank Zurich Cantonalbank raised its stake in shares of Cerevel Therapeutics Holdings, Inc. (NASDAQ:CERE Get Rating) by 30.3% during the 1st quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor owned 7,134 shares of the biotechnology companys stock after acquiring an additional 1,657 shares during the quarter. Zurcher Kantonalbank Zurich Cantonalbanks holdings in Cerevel Therapeutics were worth $250,000 at the end of the most recent reporting period.

Several other hedge funds and other institutional investors have also bought and sold shares of CERE. Candriam Luxembourg S.C.A. bought a new stake in Cerevel Therapeutics during the 4th quarter valued at $3,424,000. Adage Capital Partners GP L.L.C. lifted its holdings in shares of Cerevel Therapeutics by 24.0% during the 4th quarter. Adage Capital Partners GP L.L.C. now owns 310,000 shares of the biotechnology companys stock valued at $10,050,000 after purchasing an additional 60,000 shares during the last quarter. First Trust Advisors LP lifted its holdings in shares of Cerevel Therapeutics by 105.8% during the 4th quarter. First Trust Advisors LP now owns 107,026 shares of the biotechnology companys stock valued at $3,470,000 after purchasing an additional 55,029 shares during the last quarter. Rafferty Asset Management LLC lifted its holdings in shares of Cerevel Therapeutics by 65.1% during the 4th quarter. Rafferty Asset Management LLC now owns 135,197 shares of the biotechnology companys stock valued at $4,383,000 after purchasing an additional 53,303 shares during the last quarter. Finally, Woodline Partners LP lifted its holdings in shares of Cerevel Therapeutics by 21.5% during the 4th quarter. Woodline Partners LP now owns 237,326 shares of the biotechnology companys stock valued at $7,694,000 after purchasing an additional 41,995 shares during the last quarter.

Several brokerages have recently commented on CERE. The Goldman Sachs Group decreased their price objective on Cerevel Therapeutics from $28.00 to $20.00 and set a neutral rating for the company in a report on Tuesday, May 24th. Mizuho assumed coverage on Cerevel Therapeutics in a research note on Wednesday, July 6th. They issued a neutral rating and a $30.00 target price for the company. Two equities research analysts have rated the stock with a hold rating and five have issued a buy rating to the stock. Based on data from MarketBeat, Cerevel Therapeutics currently has an average rating of Moderate Buy and a consensus price target of $39.43.

Shares of CERE stock opened at $26.97 on Friday. The firm has a market capitalization of $4.00 billion, a price-to-earnings ratio of -15.77 and a beta of 2.44. The business has a fifty day moving average of $26.18 and a 200 day moving average of $28.77. Cerevel Therapeutics Holdings, Inc. has a 1 year low of $19.86 and a 1 year high of $46.16.

Cerevel Therapeutics (NASDAQ:CERE Get Rating) last released its quarterly earnings data on Tuesday, May 10th. The biotechnology company reported ($0.46) earnings per share for the quarter, missing analysts consensus estimates of ($0.44) by ($0.02). During the same quarter last year, the firm posted ($0.40) earnings per share. As a group, equities research analysts expect that Cerevel Therapeutics Holdings, Inc. will post -1.94 earnings per share for the current year.

(Get Rating)

Cerevel Therapeutics Holdings, Inc, a clinical-stage biopharmaceutical company, engages in the development of various therapies for neuroscience diseases. It is developing emraclidine, a positive allosteric modulator (PAM) that is in phase 1b clinical trials for the treatment of schizophrenia; and Darigabat, a PAM, which is in Phase 2 proof-of-concept trial in patients with drug-resistant focal onset seizures in epilepsy or focal epilepsy, as well as in phase 1 trial to treat acute anxiety.

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Zurcher Kantonalbank Zurich Cantonalbank Buys 1657 Shares of Cerevel Therapeutics Holdings, Inc. (NASDAQ:CERE) - Defense World

Red Wine: Is it really healthy? Find out – Web News Observer

There is no denying that wine has been an integral part of many peoples lives over the years. Moreover, the benefits associated with it have also been documented after research for a long time. R&D on red wine continues even now while suggesting that drinking it in moderation offers certain benefits. So, red wine, when consumed in moderation, is said to keep the heart healthy. There are certain substances present in the wine, especially antioxidants, that may help prevent coronary artery diseases that lead to heart attacks.

However, you must remember the fact that healthcare providers do not recommend drinking alcohol for your hearts benefit. There is no denying that too much alcohol is, of course, too much harmful for your body.

The antioxidants present in red wine called polyphenols help protect blood vessel linings in the heart. There is another polyphenol called resveratrol present in red wine that is known to benefit the hearts health.

Now, the question that arises here is whether red wine is healthy. Let us delve deeper into some of its benefits.

If you drink red wine, it may lower the risk of cardiovascular diseases. The antioxidants called polyphenols in red wine keep the blood vessels flexible by preventing unwanted clotting in your heart.

According to studies, people who consume red wine three to four times a week are 30% less prone to developing diabetes compared to those who drink it for less than a week. The polyphenols in red wine may help control blood sugar levels.

As mentioned earlier, resveratrol is a significant ingredient present in red wine that may help destroy malignant cells in the body. It also helps protect normal tissues from getting destroyed due to the radiation that is given to cancer patients.

Consuming wine helps convert bad fats to calorie-burning brown fats. Wine is known to combat obesity as it helps increase the metabolic rate in the body.

Wine is known to lower blood pressure as it increases nitric oxide levels in the blood. It also helps you get relief from stress and prevents high blood pressure.

As mentioned above, no health expert will ever recommend you to have red wine to prevent heart diseases or regulate any health issues in your body. It is because alcohol is addictive and can even worsen your health problems. So, if you want to consume red wine, try to have it in moderation with an experts advice.

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Red Wine: Is it really healthy? Find out - Web News Observer

Pet nutrition: 5 healthy and tasty fruits for your pets – Hindustan Times

Fruits are full of fibre and antioxidants and as healthy for your furry babies as for you. However, care must be taken to choose the correct fruit for your dog or cat as a few can be toxic for them and cause adverse reaction. Experts say it is best to avoid any fruits that have small seeds or bits in them that may get stuck in your canine or feline companion's intestinal tracts. Otherwise most of the fruits can be included in your pet's diet from apple to watermelon. Fruits can also be the perfect snacks for them considering the sweet or deep fried stuff can cause many health problems in pets. (Also read: Is your pet ageing? Here are ways to take care of your senior pet)

"There are many seasonal fruits that are good for dogs and can be given in moderate amounts. Make sure to avoid the toxic ones. Grapes, cherries and avocados are fatal for dogs. Most importantly, make fruits fun. Make your dog work for these treats and associate happy times with fruits. You could also make healthy fruits into smoothies and freeze them in ice trays," said Dr Dilip Sonune, Veterinary Officer at Wiggles. (Also read: Mental health benefits of sleeping with your pet)

Ideal fruits for dogs, cats and parrots

What is also important to note is that many of these fruits are very high in sugar, like bananas and mangoes and so should be given in small quantities and less frequently. For both cats and dogs, one must steer away from avocado, cherries, grapes and tomatoes which can, in cases, even lead to sudden death of the animal. Berries in general are safe for cats to consume. Parrots can eat almost every fruit and it is a must to include at least 5-10% of fruit in your parrots diet," says Devanshi Shah, Founder & CEO, PetKonnect.

Here are 5 important fruits suggested by Dr Dilip Sonune, pet parents can give to their little companions.

Apples: Apples are extremely healthy for your pets. It consists of antioxidants and lots of Vitamin A and C. Apples contain a great source of potassium, flavonoids and phytonutrients which keep your pet healthy. It's advisable to wash apples properly and cut them into small pieces after peeling the core. Apple seeds contain cyanide and if pets consume that, it can not only be harmful but over time it can cause severe health issues as well.

Bananas: Pets can eat bananas as they are rich and high in potassium, carbohydrates, vitamins, biotin, fiber, and are low in calories too. They should be given in moderation and with the peel removed. Giving too much bananas can lead to constipation. Pets with kidney failure, blood pressure and severe heart conditions should not be given bananas.

Watermelon: Watermelons are fresh and a great fruit to give your pets. It contains high water content, essential minerals, vitamin A, B-6, C and Thiamin. Pet parents should be careful and remove all the seeds as it may cause blockages in the pets intestines.

Strawberries: Strawberries are low-calorie, full of antioxidants, high in fibre and Vitamin C and help in whitening your pets teeth. They also contain anti-aging properties. Strawberries should be given in limited amounts as they contain sugar which can be harmful for pets.

Blueberries: Blueberries are dogs' favorite. They contain natural elements like vitamins, minerals and antioxidants that help in reducing risk of diabetes, heart attacks, liver failure etc. The fruit also contains high levels of resveratrol which fight cancers in dogs. Tannis found in blueberries can prevent urinary tract infections and are good for eye health.

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Assistant Professor of the Department of Biochemistry job with MASARYK UNIVERSITY | 301365 – Times Higher Education

Department:Department of BiochemistryFaculty of MedicineDeadline:21 Aug 2022Start date:September 2022 or upon agreementJob type:full-time | part-timeJob field:Science and research | Education and schooling

The Dean of the Faculty of Medicine of Masaryk Universityappoints aselection procedure for the position ofAssistant Professor of the Department of Biochemistryfull-time or part-time

The Department of Biochemistry is an educational and research facility at the Faculty of Medicine, Masaryk university. It ensures the teaching of students in theoretical and pre-clinical fields. For more information about us visitourwebsite,FacebookorInstagram.

Description of significant activities:

The requirements are:

We offer:

Start Date:1st September 2022 or upon agreementWorkplace:Bohunice University Campus, Kamenice 753/5,62500Brno,Czech RepublicWorking hours:full-time 40 hours per week, or part-time by agreementType of contract:employment relationship for 1 year with the possibility for extentionin the futureApplication deadline:21st August 2022

How to apply:

Submit your application by the above deadline. Please use the link in the Electronic application section (see below).

Your application must include the following documents:

After successfully submitting your application, you will receive an automatic confirmation by email. We can provide you with more detailed information on phone number 54949 6613 or e-mail vendula.novotna@med.muni.cz.

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Assistant Professor of the Department of Biochemistry job with MASARYK UNIVERSITY | 301365 - Times Higher Education

Post-Doctoral Associate in the Division of Science, Biochemistry, Dr. Azam Gholami job with NEW YORK UNIVERSITY ABU DHABI | 300813 – Times Higher…

Description

Applications are invited for a fully-funded Post-Doctoral Associate position in the newly established multidisciplinary group of Prof. Azam Gholami at New York University Abu Dhabi. The appointed candidate will be expected to work on:

We seek a highly qualified candidate with a strong background in protein production and purification with a focus on trans-membrane proteins. The appointed candidate will be expected to be familiar with bacterial protein expression and chromatographic purification techniques. Expertise in the reconstitution of membrane proteins into lipid vesicles/polymersomes and skills in microfluidics and optical microscopy are highly advantageous.

Applicants must have a Ph.D. in protein biochemistry or a related field and an excellent track record of original research on the relevant topics. For consideration, applicants need to submit a cover letter, curriculum vitae with full publication list, statement of research accomplishments and interests and contact information for at least three references, all in PDF format. If you have any questions, please email Prof. Azam Gholami atag9141@nyu.edu

This position is not located in the United States and the applicant must be willing to relocate to Abu Dhabi, United Arab Emirates.

The terms of employment are very competitive and include housing and educational subsidies for children. Applications will be accepted immediately and candidates will be considered until the position is filled.

About NYUAD

NYU Abu Dhabi is a degree-granting research university with a fully integrated liberal arts and science undergraduate program in the Arts, Sciences, Social Sciences, Humanities, and Engineering. NYU Abu Dhabi, NYU New York, and NYU Shanghai, form the backbone of NYUs global network university, an interconnected network of portal campuses and academic centers across six continents that enable seamless international mobility of students and faculty in their pursuit of academic and scholarly activity. This global university represents a transformative shift in higher education, one in which the intellectual and creative endeavors of academia are shaped and examined through an international and multicultural perspective. As a major intellectual hub at the crossroads of the Arab world, NYUAD serves as a center for scholarly thought, advanced research, knowledge creation, and sharing, through its academic, research, and creative activities.

EOE/AA/Minorities/Females/Vet/Disabled/Sexual Orientation/Gender Identity Employer

UAE Nationals are encouraged to apply

Equal Employment Opportunity Statement

For people in the EU, click here for information on your privacy rights under GDPR:www.nyu.edu/it/gdpr

NYU is an equal opportunity employer committed to equity, diversity, and social inclusion.

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Post-Doctoral Associate in the Division of Science, Biochemistry, Dr. Azam Gholami job with NEW YORK UNIVERSITY ABU DHABI | 300813 - Times Higher...

Advice: How pre-med freshmen can start preparing now – The Cougar – The Daily Cougar

By Olivia Tran July 18, 2022

Juana Garcia/The Cougar

So, youve decided you want to be a doctor. Welcome to the pre-med world at UH it can be a long and crazy ride, but if youre confident you want to be a physician and are willing to work hard towards your dream, you can get there. As someone who initially felt lost, here are a few things I wish Id known going in.

You can major in anything and still be pre-med. No major is better than another for medical school admissions, so pick something that interests you and that you can do well in. While majors like biology include many of the prerequisite classes required for medical school and surround you with other UH pre-meds, non-science majors can add variety to your courses and allow you to meet people outside your pre-med bubble.

Most medical schools require general biology, general and organic chemistry, biochemistry, physics, statistics, English and advanced biology, for example genetics, regardless of major. Check the UH pre-health website to see what classes count towards these.

Do your best to do well in them- schools look at biology, chemistry, physics and math grades. Being engaged in class will make it easier to do well in future courses and exams and secure strong letters of recommendation.

Community service goes a long way as a pre-med student, as it shows your desire to help those around you. Whether you tutor middle school students through a campus organization or help at a nearby animal shelter, try to show consistency and initiative in something that matters to you.

You can even create service projects as you gain more experience. Student organizations can help you access volunteer opportunities and leadership roles.

Clinical experience can be anything from volunteering in a hospital to working as a medical scribe. In contrast, shadowing means you follow a doctor around and observe their daily activities. Its essential to have both to understand the realities of the medical field maybe youll find its not for you, and thats OK.

These experiences can be hard to find, especially if you want a specific schedule, location or salary. So youll have to be proactive and get used to cold calling. Since UH is near the Texas Medical Center, you can find many opportunities that are just a short car or Metro ride away.

While research isnt strictly required, medical schools appreciate applicants who show critical thinking and scientific inquiry. Opportunities include wet lab pipetting, mice work, computer modeling, translational and clinical research, health disparities and even research completely outside of health.

Most UH labs are willing to take on undergraduates, but you must be eager and persistent when asking to join. Cold emailing to ask for a meeting with the professor in charge of the lab, the principal investigator, is a typical way to start. You can also reach out to the Office of Undergraduate Research and Major Awards.

Non-medical employment can pay the bills and boost your application. Being a waitress or cashier shows you have people skills, are dependable and can balance a real job with school. These often pay more than entry-level clinical jobs, so its something to consider if you find yourself strapped for cash.

Dont forget to keep up with what makes you, you. Whether rock climbing, drawing or just getting boba with friends, these activities can help you de-stress and can also be put on your application if they are significant to you.

I put this last because you dont need to stress about it yet. The Medical College Admissions Test consists of four sections- chemistry/physics, reading, biology/biochemistry and psychology/sociology.

Students usually take it between sophomore and junior year at the earliest, with most taking it during the spring semester of their junior year if they want to enter medical school right after graduation. The most important thing you can do to prepare as a freshman is to do well in your relevant classes and retain the material.

If you feel overwhelmed already, dont be. No one is perfect in all these aspects nor capable of focusing on all of them simultaneously. Medical schools understand if your circumstances prevent you from doing as much as youd like. Be sure to check out the UH Pre-Health Advising Center website for more detailed information, and best of luck as you begin your journey.

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Advice: How pre-med freshmen can start preparing now - The Cougar - The Daily Cougar

U-M researchers track protein binding, build synthetic proteins to study gene expression – University of Michigan News

How does a nose remember that its a nose? Or an eye remember that its an eye?

As scientists probe the question of how cells remember what kind of cells they are supposed to be, or their genetic lineage, its important to understand how cells express different genes without changing the DNA sequence itself.

But studying this subject is difficult: Researchers can purify the proteins that drive genetic expression, put them in a test tube and watch them bind. But doing so inside the nucleus of cells, their native environment, has been so far impossible.

Study: HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization (DOI: 10.1126/sciadv.abk0793)

Now, a team of researchers at three University of Michigan labs have been able to track how a protein binds to its chromatin substrate within a living cell by establishing a collaboration that combines state-of-the-art ultra high-resolution imaging, synthetic protein design and computational modeling. Their results are published in Science Advances.

The biological question that were asking is, How do cells actually remember past experiences? And how do these experiences also lead to cells establishing distinct identities, as it happens in the case of the human body where you have lineages of cells that form neurons, or blood cells, or brain cells, and all actually maintain their identities for many generations,' said lead author Kaushik Ragunathan, assistant professor of biological chemistry at the U-M Medical School.

An example I like to think about is that if you chop off your nose, you dont get a hand growing there, even though the genome in your nose and the genome in your hand are exactly the same.

Cells control how and which genes are expressed from a copy of the DNA sequence held within each cell, despite that sequence being the same across all cells in the body. One way they control expression is by changing how tightly the DNA is packaged within the nucleus using proteins called histones. Histones can be modified through the addition of small chemical tags that regulate how tightly the DNA is wound around them and thus whether the genes can be expressed.

Proteins that have the ability to read, write and erase these histone tags explore the DNA within the nucleus of the cell very rapidlyon the order of milliseconds, according to Ragunathan. Ultimately, all this epigenetic information needs to be inherited across generations, but the recognition of these tags is a complicated process that involves chromatin binding and proteins meeting and interacting with each other amidst the chaos of all other possible competing interactions within the cell.

Being able to understand each step of the processand therefore enabling control of how the epigenetic information is inheritedintrigued co-author Julie Biteen, professor of chemistry and biophysics.

Biteen uses single-molecule fluorescence imaging to track individual proteins inside cells. Her lab can see where these proteins are relative to the chromatin, and Ragunathans expertise is in the molecular mechanisms underpinning how histone modifications and histone-binding proteins interact. These two worlds needed to come together so that the biochemistry of what happens in a test tube outside of cells could be tested to figure out what happens inside of them.

The timing of this process is critically important to ensure that the right genes are silenced at the right place and at the right time, Biteen said. What hooked me on this project is that in vitroin a test tubeyou can purify two proteins, watch them bind and see how good that binding is, or what is the affinity for one another. That tells you what can happen in the cells, but not what does happen in the cells.

Biteen and Ragunathan worked with Peter Freddolino, associate professor of biological chemistry, and computational medicine and bioinformatics at the U-M Medical School, to combine computer modeling with their experimental results.

This is really where our collaboration becomes really powerful, Biteen said. On one hand, seeing molecules is very helpful and knowing how fast the molecules move helps a lot in terms of understanding what is possible inside the cell, but here we could take a leap forward by perturbing the system even in unnatural ways in order to understand what these different motions of molecules in the cell actually mean.

While epigenetic marks are tremendously important for maintaining different tissues in complex organisms like humans, they also play an important role in regulating genes of single-celled organisms such as yeast. The team focused on a type of HP1 protein in yeast cells called Swi6. This family of proteins binds to a specific type of histone modifications in the cell to enforce gene silencing. By integrating fluorescent labels with Swi6, Bitees lab watched Swi6 move inside the cells nucleus.

While Swi6 searches for the correct binding site on DNA, it moves quickly, Biteen said. When it finds its target, it slows down significantly. The movement of a protein within the cell is akin to gears in a car and things can move at different speeds based on whom proteins interact with.

From these spaghetti tracks that we get inside the cell, we then figure out how much time they are spending searching and how much of the time they are spending bound, Biteen said. The amount of time they spend not moving tells us about how strongly theyre interacting and their biochemical properties.

While Biteens lab can measure movements in the cell on the scale of tens of milliseconds, much of the biochemistry happening in the cell is happening even faster, she said. Freddolino took this experimental information and developed models to estimate the ability of the Swi6 proteins to jump between the binding states that were identified in experiments.

Freddolinos modeling took into account the experimental measurements and the possible biochemical properties, which includes how the Swi6 molecules interact in the cell. These interactions include molecules that freely float in the solution of the cell, molecules that have bound to DNA, and molecules that are holding hands with each other, he said.

My lab wanted to come up with a more fine-grained model that estimated what was the most likely set of molecular states of the proteins and their ability to jump between those states, that would then give rise to the imaging data that Biteens lab created, Freddolino said.

Having this numerical model allows us to do the computational experiments of what happens if the protein binding is twice as fast as we think. What if its 10 times as fast as we think? Or 10 times slower? Could that still give rise to the data? Very happily, in this case, we were able to show that the relevant processes were really being captured in the fluorescence microscopy.

After identifying the binding properties of natural Swi6, the researchers tested their findings by redesigning Swi6 from its components to see whether they could replicate some of its biochemical properties, Ragunathan said. This allowed the researchers to determine that the imaging and modeling conducted in the first part of the paper reflects how the protein was binding in its native environment.

Can we do what nature did over the course of millions of years and make a protein that in many ways has properties similar to that of Swi6 in cells? Ragunathan said. In vivo biochemistry, which is what weve decided to call this, was not something that was ever thought to be possible inside living cells, but we have shown this is entirely feasible by using imaging as a modality. We are using this project as a foundation in order to understand how these epigenetic states can be established and maintained across generations.

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U-M researchers track protein binding, build synthetic proteins to study gene expression - University of Michigan News

Europe Amicarbazone Market Quantitative Analysis, Opportunistic Scope, Possibilities Of The Sector By Region Travel Adventure Cinema – Travel…

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Calcium Citrate Market Insights 2021 to 2028, Research By Key Players Jungbunzlauer, Gadot Biochemical Industries, Sucroal, Saminchem Inc, Jost…

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PCOS in mothers is linked to increased risk of health problems in their children – EurekAlert

Children born to mothers with polycystic ovary syndrome (PCOS) have an increased risk of developing infections, allergies and other childhood illnesses by the age of 13, according to the largest study to investigate this.

The study, which is published today (Thursday) in Human Reproduction [1], one of the worlds leading reproductive medicine journals, looked at 1,038,375 children born in Quebec, Canada, between 2006 and 2020. Of these, 7,160 children were born to mothers with PCOS.

The researchers found that children of mothers with PCOS were 32% more likely to be admitted to hospital with a variety of health problems than children of mothers without PCOS. They were 31% more likely to be admitted for infectious diseases and 47% more likely to be admitted for allergy-related problems, such as asthma.

The risk of hospitalization was increased for problems relating to metabolism (up by 59%), the gut (72%), central nervous system (74%), and ears (34%); it was also increased for respiratory problems, such as pneumonia (32%), and mental and behavioural problems (68%). There was no link with cancer, and there was little difference between boys and girls in the association of PCOS with hospitalisation.

PCOS is a common disorder of the ovaries that can affect up to 10% of women of reproductive age. The main features are irregular periods, high levels of the male hormone androgen, which may cause excess facial or body hair, and the ovaries can become enlarged and contain fluid-filled sacs (follicles) that surround the eggs. PCOS can make it difficult for women to become pregnant, and can cause weight gain, thinning hair and oily skin or acne. Women with PCOS are at risk of obesity, type 2 diabetes and diseases of the heart and blood vessels. Several studies have shown links with problems in pregnancy and birth, such as gestational diabetes, pre-eclampsia and preterm birth. However, the long-term effect of PCOS on offspring is poorly understood and has received little attention.

Dr Nathalie Auger, associate professor of epidemiology at the School of Public Health, University of Montreal, Canada, who led the study, said: These findings fill a big gap in what we know about the long-term health of children whose mothers have PCOS. Primary care doctors and obstetricians should consider identifying women with PCOS before conception and offering early interventions such as weight management and strategies to help prevent problems such as diabetes and heart and blood vessel diseases. Family doctors and paediatricians should consider monitoring children more closely after birth to minimise morbidity. Greater parental awareness may help improve outcomes in children.

As this is an observational study, it is unable to show that PCOS causes health problems in children, only that it is associated with them, and it cannot show what mechanisms may be involved. However, Dr Auger said: Women with PCOS may have high levels of androgen and insulin resistance, which have been linked to problems with the placenta, such as inflammation of the membrane surrounding the foetus, damage to tissue and impaired function of the placenta. These create a suboptimal environment in the womb for babies that could lead to impaired immune function and low-grade systemic inflammation.

She said genetic factors could also play a role, with the environment in the womb causing modifications in how some genes work in offspring.

The researchers adjusted their findings to take account of factors that could affect the results such as mothers other health problems, age, parity, alcohol and tobacco use, and socioeconomic deprivation. They found that the associations between maternal PCOS and the health of offspring were not explained by fertility treatments, multiple births, preterm births or the mothers other health problems.

Strengths of the study include its size and the fact that it evaluated a wide range of infections, allergies and malignant disease, as well as specific health problems such as respiratory, cardiovascular, metabolic, gastrointestinal, urinary, genital, musculoskeletal, central nervous system, ear, eye and mental and behavioural disorders.

Limitations include the fact that the researchers used data from the Maintenance and Use of Data for the Study of Hospital Clientele repository, which contains discharge records for all inpatients, which meant that they only analysed outcomes for children that were admitted to hospital. They could not identify women with mild PCOS who were never diagnosed or children with less severe illnesses who were not treated in hospital. They also lacked data on ethnicity, education, pre-pregnancy body mass index, weight gain during pregnancy, physical activity, information about the use of medications such as metformin, and the age of fathers.

We believe that further research is needed to see if effective management of maternal PCOS can reduce the risk of health problems in offspring and improve long-term health. We need to know if exercise, dietary changes and medications can make a difference, said Dr Auger.

In future work, we intend to examine outcomes of pregnancy, as well as future outcomes of women with PCOS. These women may be at risk of developing cardiovascular disease or other health problems, and epidemiologic research documenting this possibility is needed to help improve the management of these patients.

(ends)

[1] Association of PCOS with offspring morbidity: a longitudinal cohort study, by Shu Qin Wei et al. Human Reproduction journal. doi:10.1093/humrep/deac154

Human Reproduction

Observational study

People

Association of PCOS with offspring morbidity: a longitudinal cohort study

14-Jul-2022

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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