National Nanotechnology Initiative (NNI) Releases Video Trailer to Highlight Documentary on NNI over the Past 20 Years ‘NNI Retrospective Video:…

Washington, D.C., Aug. 04, 2022 (GLOBE NEWSWIRE) -- For Immediate ReleaseThursday, August 4, 2022

Contacts: TV Worldwide(703) 961-9250 ext. 221 Info@TVWorldwide.com http://www.TVWorldwide.comWashington, D.C., August 4, 2022 - TV Worldwide, since 1999, a pioneering web-based global TV network, announced that it was releasing a video trailer highlighting a previously released documentary on NNI over the past 20 years, entitled, 'NNI Retrospective Video: Creating a National Initiative'.

The video and its trailer were produced in cooperation with the National Nanotechnology Initiative (NNI), the National Science Foundation and the University of North Carolina Greensboro.

The 3-minute video trailer can be viewed by clicking here. The full video documentary can be viewed by clicking here.

Video Documentary Synopsis

Nanotechnology is a megatrend in science and technology at the beginning of the 21 Century. The National Nanotechnology Initiative (NNI) has played a key role in advancing the field after it was announced by President Clinton in January 2000. Neil Lane was Presidential Science Advisor. Mike Roco proposed the initiative at the White House in March 1999 on behalf of the Interagency Working Group on Nanotechnology and was named the founding Chair of NSET to implement NNI beginning with Oct. 2000. NSF led the preparation of this initiative together with other agencies including NIH, DoD, DOE, NASA, and EPA. Jim Murday was named the first Director of NNCO to support NSET. The scientific and societal success of NNI has been recognized in the professional communities, National Academies, PCAST, and Congress. Nanoscale science, engineering and technology are strongly connected and collectively called Nanotechnology.This video documentary was made after the 20th NNI grantees conference at NSF. It is focused on creating and implementing NNI, through video interviews. The interviews focused on three questions: (a) Motivation and how NNI started; (b) The process and reason for the success in creating NNI; (c) Outcomes of NNI after 20 years, and how the initial vision has been realized.About the National Nanotechnology Initiative (NNI)The National Nanotechnology Initiative (NNI) is a U.S. Government research and development (R&D) initiative. Over thirty Federal departments, independent agencies, and commissions work together toward the shared vision of a future in which the ability to understand and control matter at the nanoscale leads to ongoing revolutions in technology and industry that benefit society. The NNI enhances interagency coordination of nanotechnology R&D,supports a shared infrastructure, enables leveraging of resources while avoiding duplication, and establishes shared goals, priorities, and strategies that complement agency-specific missions and activities.The NNI participating agencies work together to advance discovery and innovation across the nanotechnology R&D enterprise. The NNI portfolio encompasses efforts along the entire technology development pathway, from early-stage fundamental science through applications-driven activities. Nanoscience and nanotechnology are prevalent across the R&D landscape, with an ever-growing list of applications that includes nanomedicine, nanoelectronics, water treatment, precision agriculture, transportation, and energy generation and storage. The NNI brings together representatives from multiple agencies to leverage knowledge and resources and to collaborate with academia and the private sector, as appropriate, to promote technology transfer and facilitate commercialization. The breadth of NNI-supported infrastructure enables not only the nanotechnology community but also researchers from related disciplines.In addition to R&D efforts, the NNI is helping to build the nanotechnology workforce of the future, with focused efforts from K12 through postgraduate research training. The responsible development of nanotechnology has been an integral pillar of the NNI since its inception, and the initiative proactively considers potential implications and technology applications at the same time. Collectively, these activities ensure that the United States remains not only the place where nanoscience discoveries are made, but also where these discoveries are translated and manufactured into products to benefit society.About TV Worldwide

Founded in 1999, TV Worldwide.com, Inc. (t/a TV Worldwide, Inc., http://www.TVWorldwide.com) is a veteran-owned Internet TV solutions company that developed the first network of community-based Internet TV channels, primarily targeting niche enterprise/professional audiences ranging from the maritime industry to the cybersecurity and federal/public sectors. Known by many in the industry as "Intelligent Internet TV," Fortune 500 companies, 40 federal government agencies, and numerous associations including the National Association of Broadcasters have partnered with TV Worldwide to utilize TV Worldwide's live and on-demand state-of-the art video streaming content applications and Internet TV channels. In recognition of the company's pioneering unique achievements in new media solutions and content development, TV Worldwide has been selected by the National Academy of Television Arts and Sciences (NATAS) to webcast past Daytime Emmy Awards and the Emmy awards for Technology and Engineering. TV Worldwide Chairman and CEO Dave Gardy, has been honored by Streaming Media Magazine as one of the 25 Most Influential People in Streaming Media. Mr. Gardy also has served as the President of the International Webcasting Association (IWA) and was a member of the Vietnam Veterans Memorial Fund Corporate Council.

Contacts: TV Worldwide(703) 961-9250 ext. 221 Info@TVWorldwide.com http://www.TVWorldwide.com

###

Follow this link:
National Nanotechnology Initiative (NNI) Releases Video Trailer to Highlight Documentary on NNI over the Past 20 Years 'NNI Retrospective Video:...

Ultra Precision Machine Tools Market Executive Summary and Analysis by Top Players 2022-2028: Fives, Moore Nanotechnology Systems, Hardinge, Inc …

The 2022-2028, Global Ultra Precision Machine Tools Market by MarketsandResearch.biz research contains Ultra Precision Machine Tools market share analysis, winning techniques, recent developments, and financials for global, regional, and top players. The study recalculates the impact of macroeconomic and microeconomic factors that have the potential to affect the growth of the Ultra Precision Machine Tools market, as well as providing data on the major players in the Ultra Precision Machine Tools industry.

Furthermore, utilising the frameworks of SWOT and Porters Five Forces analysis, key insights into the Ultra Precision Machine Tools market market have been provided, as well as the markets attractiveness as evaluated by sales, revenue, distribution channel, product type, and region. The study also looks at the industrys major potential, future trends, main drivers, and roadblocks.

DOWNLOAD FREE SAMPLE REPORT: https://www.marketsandresearch.biz/sample-request/244760

Firm, region, type, and application are the four categories that make up the global Ultra Precision Machine Tools market. By utilising the study as a useful resource, companies, stakeholders, and other players in the global Ultra Precision Machine Tools market will get an edge.

The Ultra Precision Machine Tools market major Players include:

This research shows the production, revenue, price, market share, and growth rate of each product category, which is basically divided into:

This research focuses on the status and prognosis for key application, consumption (sales), market share, and growth rate for each application based on applications, including:

The primary regions addressed in the report are:

ACCESS FULL REPORT: https://www.marketsandresearch.biz/report/244760/global-ultra-precision-machine-tools-market-2021-by-manufacturers-regions-type-and-application-forecast-to-2026

It consists of market trends, constraints, and drivers that have a positive or negative impact on the market. This section also discusses the many categories and applications that may have an impact on the market in the future. The data is based on current trends as well as historical milestones.

Customization of the Report:

This report can be customized to meet the clients requirements. Please connect with our sales team (sales@marketsandresearch.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on 1-201-465-4211 to share your research requirements.

Contact UsMark StoneHead of Business DevelopmentPhone: 1-201-465-4211Email: sales@marketsandresearch.biz

Read the original here:
Ultra Precision Machine Tools Market Executive Summary and Analysis by Top Players 2022-2028: Fives, Moore Nanotechnology Systems, Hardinge, Inc ...

FACTSHEET: Imposing Additional Costs on Russia for Its Continued War Against Ukraine – US Embassy and Consulate in Poland

FACT SHEET

OFFICE OF THE SPOKESPERSON

AUGUST 2, 2022

The United States is committed to working alongside our allies and partners to further impose severe consequences on President Putin and his enablers for Russias unconscionable war against Ukraine.

VISA RESTRICTIONS

The Department of State is announcing a series of actions to promote accountability for actions by Russian Federation officials and others that implicate violations of Ukraines sovereignty to include:

DESIGNATION OF PUTIN ENABLERS

The Department of State is designating oligarchsDMITRIY PUMPYANSKIY,ANDREY MELNICHENKO, andALEXANDER PONOMARENKO.

The Department of State is designating four individuals and one entity that are or are enabling illegitimate, political leaders installed by Russia or its proxy forces to undermine political stability in Ukraine in support of Russias further invasion of Ukraine. The four individuals and the entity are being designated pursuant to Section 1(a)(ii)(F) of E.O. 14024, for being responsible for or complicit in, or having directly or indirectly engaged or attempted to engage in, activities that undermine the peace, security, political stability, or territorial integrity of the United States, its allies, or its partners, for or on behalf of, or for the benefit of, directly or indirectly, the Government of the Russian Federation.

Pursuant to Section 1(a)(vii) of E.O. 14024, the Department of State is designatingJOINT STOCK COMPANY STATE TRANSPORTATION LEASING COMPANY (JSC GTLK)for being owned, controlled by, or having acted or purported to act for or on behalf of, directly or indirectly, the Government of the Russian Federation. JSC GTLK is a Russian state-owned enterprise that the Russian Ministry of Transportation oversees. It is the largest transportation leasing company in Russia. JSC GTLK is an important part of Russias transportation networks due to its leases of railroad cars, vessels, and aircraft on favorable terms to support Russias development strategy. JSC GTLK has been previously designated by the U.K. and E.U.

Pursuant to Section 1(a)(vii) of E.O. 14024, the Department of State is designating the following four JSC GTLK subsidiaries for being owned or controlled by, or having acted or purported to act for or on behalf of, directly or indirectly, JSC GTLK. These companies leased JSC GTLKs transportation equipment outside of Russia and /or enabled JSC GTLK to access capital from western financial markets to fund its activities.

DESIGNATION OF DEFENSE AND HIGH-TECHNOLOGY ENTITIES

Under the leadership of U.S.-designated Russian President Vladimir Putin, the Russian Federation has systematically focused on exploiting high-technology research and innovations to advance Russias defense capabilities. Putin has also repeatedly underscored his concerns about Russias access to microelectronics. Advanced technologies such as microelectronics are used in numerous weapon systems used by Russias military. Today, the Department of State is imposing sanctions on numerous Russian high-technology entities as a part of the United States efforts to impose additional costs on Russias war machine.

The Department of State is designating theFEDERAL STATE INSTITUTION OF HIGHER VOCATIONAL EDUCATION MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY (MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY) (MIPT)pursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the defense and related materiel sector of the Russian Federation economy. MIPT has developed drones for Russias military that are intended to be used in direct contact with enemy forces, has won an award from Russias Ministry of Defense for developing technologies in the interests of the Armed Forces of the Russian Federation, and promotes that it focuses on conducting innovative research and development in the defense and security fields. MIPT has worked with a leading Russian fighter aircraft developer to design a visualization system related to fighter aircraft and has a laboratory that supports Russias military space sector. MIPT is also part of a consortium of Russian institutions involved in training specialists for Russias defense-industrial complex and has collaborated on research projects with a Russian defense research organization.

The Department of State is designating theSKOLKOVO FOUNDATIONpursuant to E.O. Section 1(a)(i) of 14024 for operating or having operated in the technology sector of the Russian Federation economy. The Skolkovo Foundation was established by a Russian Federation law in 2010 to manage the Skolkovo Innovation Center, which consists of the Technopark Skolkovo Limited Liability Company and the Skolkovo Institute of Science and Technology (Skoltech), which are also being designated as part of this action. Since its founding, the Skolkovo Foundation has focused on supporting the development of technologies to contribute to technology sectors prioritized by the Russian Federation government including strategic computer technologies, technologies for maintaining Russias defense capabilities including with regard to advanced and sophisticated weapons, and space technologies related to Russias national security. As additional information, the Skolkovo Innovation Center has hosted U.S.-designated Rosoboronexport, Russias state-controlled arms export agency, as a part of Rosoboronexports efforts to export weapons to foreign clients.

The Department of State is designating theSKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY (SKOLTECH)pursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the technology sector of the Russian Federation economy. Skoltech is a pioneer in cutting-edge technologies and seeks to foster new technologies to address critical issues facing the Russian Federation. As additional information, for nearly a decade, Skoltech has had a close relationship with Russias defense sector. Contributors to Skoltechs endowment include numerous sanctioned Russian weapon development entities including JSC Tactical Missiles Corporation, Uralvagonzavod (which makes Russian tanks), JSC MIC Mashinostroyenia (which manufactures Russian missiles), JSC United Aircraft Corporation (which manufactures Russias combat aircraft), JSC Concern Sozvezdie (which produces electronic warfare systems for the Russian military), JSC Almaz-Antey (which manufactures Russias surface-to-air missiles systems), and JSC Corporation Moscow Institute of Thermal Technology (which manufactures Russian missiles). Over the course of the last decade, Skoltech has had partnerships with numerous Russian defense enterprises including Uralvagonzavod, United Engine Corporation, and United Aircraft Corporation which have focused on developing composite materials for tanks, engines for ships, specialized materials for aircraft wings, and innovations for defense-related helicopters. Skoltech has also presented advanced robotics at the Russian Ministry of Defenses premier defense exhibition.

The Department of State is designatingTECHNOPARK SKOLKOVO LIMITED LIABILITY COMPANYpursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the technology sector of the Russian Federation economy. Technopark Skolkovo Limited Liability Company is one of the largest technology development parks in Eurasia and hosts events related to technology.

The Department of State is designating numerous additional Russian high-technology entities as a part of our effort to isolate Russias technology sector in order to limit its contributions to Russias war machine.

Specifically, the Department of State is designating the following entities pursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the technology sector of the Russian Federation economy:

The Department of State is designating the following entities pursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the electronics sector of the Russian Federation economy:

The Department of State is designatingFEDERAL STATE BUDGETARY SCIENTIFIC INSTITUTION RESEARCH AND PRODUCTION COMPLEX TECHNOLOGY CENTERpursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the technology sector and the electronics sector of the Russian Federation economy. Federal State Budgetary Scientific Institution Research and Production Complex Technology Center develops and produces integrated circuits including application specific-integrated circuits, which are a type of high-technology electronic component, and also is involved in Russias semiconductor industry.

The Department of State is designatingJSC SCIENTIFIC RESEARCH INSTITUTE SUBMICRONpursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the aerospace sector of the Russian Federation economy. JSC Scientific Research Institute Submicron specializes in the design and development of components for computer systems for aviation and space control systems, as well as the development of other digital and data systems for aviation and space systems. As additional information, the main customers of JSC Scientific Research Institute Submicron are Russias Ministry of Defense and Air Force.

The Department of State is designatingACADEMICIAN A.L. MINTS RADIOTECHNICAL INSTITUTE JOINT STOCK COMPANYpursuant to Section 1(a)(i) of E.O. 14024 for operating or having operated in the defense and related materiel sector of the Russian Federation economy. Academician A.L. Mints Radiotechnical Institute Joint Stock Company is involved in developing technologies and systems for Russian military air defense systems.

SANCTIONS IMPLICATIONS

As a result of todays action, all property and interests in property of the individuals above that are in the United States or in the possession or control of U.S. persons are blocked and must be reported to OFAC. In addition, any entities that are owned, directly or indirectly, 50 percent or more by one or more blocked persons are also blocked. All transactions by U.S. persons or within (or transiting) the United States that involve any property or interests in property of designated or blocked persons are prohibited unless authorized by a general or specific license issued by OFAC, or exempt. These prohibitions include the making of any contribution or provision of funds, goods, or services by, to, or for the benefit of any blocked person and the receipt of any contribution or provision of funds, goods, or services from any such person.

By U.S. Mission Poland | 3 August, 2022 | Topics: Events, News

Link:
FACTSHEET: Imposing Additional Costs on Russia for Its Continued War Against Ukraine - US Embassy and Consulate in Poland

Ditching the toothbrush for hydrogels to get whiter teeth, fewer cavities (w/video) – Nanowerk

Aug 03, 2022(Nanowerk News) The first thing people notice when they meet you is your smile. To be more confident when giving wide-mouthed, eye-crinkling smiles, people want healthy, pearly white teeth. But toothpastes only remove surface stains, and whitening treatments can harm enamel, leading to cavities and discoloration.Now, researchers in ACS Applied Materials & Interfaces ("Fast cross-linked hydrogel as a green light-activated photocatalyst for localized biofilm disruption and brush-free tooth whitening") report a new hydrogel treatment that breaks apart cavity-forming biofilms and whitens teeth without damaging them.Daily toothbrushing and flossing are good ways to prevent cavities from forming, according to the American Dental Association. However, these methods dont effectively whiten teeth. For better whitening, consumers often turn to over-the-counter or professional treatments that combine hydrogen peroxide-containing gels and blue light, producing a chemical reaction that removes stains. This combination removes most of the discoloration, but generates reactive oxygen species that can break down enamel.Previously, Xiaolei Wang, Lan Liao and colleagues modified titanium dioxide nanoparticles for a less destructive tooth-whitening treatment. This method still required high-intensity blue light, which can damage nearby skin and eyes. So, the team wanted to find a material that would be activated by green light a safer alternative to both whiten teeth and prevent cavities.The researchers combined bismuth oxychloride nanoparticles, copper oxide nanoparticles and sodium alginate into a thick mixture. Then, they evenly coated the mixture onto the surface of teeth stuck to a slide and sprayed the concoction with a calcium chloride solution, forming a strongly adhering hydrogel.Next, the team tested the material on teeth that were stained with coffee, tea, blueberry juice and soy sauce and placed in a lab dish. Following treatment with the hydrogel and green light, the teeth got brighter over time, and there was no damage to the enamel.In another set of experiments, the team showed that the treatment killed 94% of bacteria in biofilms. To demonstrate that the treatment could work on teeth in vivo, the team used the new method on mice whose mouths were inoculated with cavity-forming bacteria.The green-light activated hydrogel effectively prevented moderate and deep cavities from forming on the surface of the animals teeth. The researchers say their safe, brush-free treatment both effectively prevents cavities and whitens teeth.

Go here to see the original:
Ditching the toothbrush for hydrogels to get whiter teeth, fewer cavities (w/video) - Nanowerk

Sunscreen made in Zimbabwe for people with albinism – The Herald

The Herald

Sifelani Tsiko Innovations Editor

A University of Zimbabwe chartered industrial chemist and pharmaceutical nanotechnology expert has developed a low-cost sun cream that not only seeks to protect the skin of people with albinism from the suns radiation but also slows down damages and infections to their skin.

Dr Joey Chifamba, who won a prize for his innovations at the just ended the University of Zimbabwe Research Innovation and Industrialisation Week, told the Herald that his ground breaking product sought to help people living with albinism who suffer from actinic (solar induced) skin damage freckles and sunburn to various skin cancers which shorten their life spans considerably.

No product has ever been developed to protect albinistic persons from actinic damage. The sunscreens that are given to them are designed for white skinned people and do not take into consideration specific conditions and differences found on albinistic skins, he said.

This makes them not very effective and not very suitable especially for all day everyday wear since albinism is a lifelong condition.

Dr Chifamba developed a product range with about 10 different products including lotions, creams, wound healing washes, lip balms and hair protective products.

All the products were made using 5th generation emerging technologies including nanotechnology and biotechnology. The products incorporated zinc and titanium from natural sources and indigenous trees, which made them crucial and suitable for people with albinism in tropical areas.

We employ nanosized metallic oxides sunblocks conjugated together with nano optimised indigenous herbs with antibacterial, antifungal and wound healing effects to create aesthetically pleasing cosmeceutical products for everyday all day use by albinistic persons, the industrial chemist and pharmaceutical nanotechnology expert.

In our innovation we have developed ground-breaking cosmeceuticals which are not only sunscreens but complete actinic damage retarding treatments that consider albinistic skin differences and deal with various symptoms of actinic damage including wrinkles, premature aging, inflammation, bacterial and fungal infections.

The products, he said, were much more affordable and safer.

Dr Chifamba said the products which were developed in consultation with the Albino charity organisation of Zimbabwe and other albino welfare groups were already available to people living with albinism who are registered with the trust.

The UZ Innovation Hub was now supporting Dr Chifamba to further develop his research and innovations.

People with albinism have pale skin due to a pigment disorder that barely protects the skin from the suns radiation.

When exposed to sunlight, the skin of an albino does not acquire a tan. Instead, it remains light and there is a greater risk of skin cancer.

In Zimbabwe and most other African countries, this is an acute problem.

Most sunscreen products that are available in Zimbabwe are imported from South Africa and are expensive.

Retailers sell the lotion at high prices that range from US$22 and $35 for a 250 millilitre bottle of sunscreen lotion.

This is much too expensive for most albinos who use a tube that only lasts a few weeks with intensive usage.

Even with donations for albino welfare organisations, the lotions are still not widely accessible from many Zimbabweans living with albinism, who number an estimated 70 000.

Albinos in Zimbabwe and on the continent still face great difficulties because of the high intensity of the suns radiation there.

In addition, Albinos in most African countries suffer from prejudice and are often rejected by their families.

In other more extreme cases, many have been killed and their bodies dismembered for ritual purposes.

In some parts of Africa, some believe albinos possess magical powers.

Albino rights activists say there is a need to improve access to skin care products for this population and promote policies that could make sunscreen easier to get and more affordable.

For years, Albino rights organisations in Zimbabwe have been lobbying the government to reduce the price of sunscreen lotions and even make them free in health facilities.

Link:
Sunscreen made in Zimbabwe for people with albinism - The Herald

Researchers 3D print high-performance nanostructured alloy that’s both ultrastrong and ductile – Nanowerk

Aug 03, 2022(Nanowerk News) Researchers at the University of Massachusetts Amherst and the Georgia Institute of Technology have 3D printed a dual-phase, nanostructured high-entropy alloy that exceeds the strength and ductility of other state-of-the-art additively manufactured materials, which could lead to higher-performance components for applications in aerospace, medicine, energy and transportation.The work, led by Wen Chen, assistant professor of mechanical and industrial engineering at UMass, and Ting Zhu, professor of mechanical engineering at Georgia Tech, is published by the journal Nature ("Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing").Wen Chen, assistant professor of mechanical and industrial engineering at UMass Amherst, stands in front of images of 3D printed high-entropy alloy components (heatsink fan and octect lattice, left) and a cross-sectional electron backscatter diffraction inverse-pole figure map demonstrating a randomly oriented nanolamella microstructure (right).(Image: UMass Amherst)Over the past 15 years, high entropy alloys (HEAs) have become increasingly popular as a new paradigm in materials science. Comprised of five or more elements in near-equal proportions, they offer the ability to create a near-infinite number of unique combinations for alloy design. Traditional alloys, such as brass, carbon steel, stainless steel and bronze, contain a primary element combined with one or more trace elements.Additive manufacturing, also called 3D printing, has recently emerged as a powerful approach to material development. The laser-based 3D printing can produce large temperature gradients and high cooling rates that are not readily accessible by conventional routes. However, the potential of harnessing the combined benefits of additive manufacturing and HEAs for achieving novel properties remains largely unexplored, says Zhu.Chen and his team in the Multiscale Materials and Manufacturing Laboratory combined an HEA with a state-of-the-art 3D printing technique called laser powder bed fusion to develop new materials with unprecedented properties. Because the process causes materials to melt and solidify very rapidly as compared to traditional metallurgy, you get a very different microstructure that is far-from-equilibrium on the components created, Chen says.This microstructure looks like a net and is made of alternating layers known as face-centered cubic (FCC) and body-centered cubic (BCC) nanolamellar structures embedded in microscale eutectic colonies with random orientations. The hierarchical nanostructured HEA enables co-operative deformation of the two phases.This unusual microstructures atomic rearrangement gives rise to ultrahigh strength as well as enhanced ductility, which is uncommon, because usually strong materials tend to be brittle, Chen says. Compared to conventional metal casting, we got almost triple the strength and not only didnt lose ductility, but actually increased it simultaneously, he says. For many applications, a combination of strength and ductility is key. Our findings are original and exciting for materials science and engineering alike.The ability to produce strong and ductile HEAs means that these 3D printed materials are more robust in resisting applied deformation, which is important for lightweight structural design for enhanced mechanical efficiency and energy saving, says Jie Ren, Chens Ph.D. student and first author of the paper.Zhus group at Georgia Tech led the computational modeling for the research. He developed dual-phase crystal plasticity computational models to understand the mechanistic roles played by both the FCC and BCC nanolamellae and how they work together to give the material added strength and ductility.Our simulation results show the surprisingly high strength yet high hardening responses in the BCC nanolamellae, which are pivotal for achieving the outstanding strength-ductility synergy of our alloy. This mechanistic understanding provides an important basis for guiding the future development of 3D printed HEAs with exceptional mechanical properties, Zhu says.In addition, 3D printing offers a powerful tool to make geometrically complex and customized parts. In the future, harnessing 3D printing technology and the vast alloy design space of HEAs opens ample opportunities for the direct production of end-use components for biomedical and aerospace applications.Additional research partners on the paper include Texas A&M University, the University of California Los Angeles, Rice University, and Oak Ridge and Lawrence Livermore national laboratories.

Go here to read the rest:
Researchers 3D print high-performance nanostructured alloy that's both ultrastrong and ductile - Nanowerk

Global Nanotechnology and Nanomaterials Market Report 2022-2032 with Profiles of Over 1,500 Nanotechnology Nanomaterials Producers and Product…

Company Logo

Dublin, Aug. 02, 2022 (GLOBE NEWSWIRE) -- The "The Global Nanotechnology and Nanomaterials Market Report 2022-2032" report has been added to ResearchAndMarkets.com's offering.

At over 1100 pages, The Global Nanotechnology and Nanomaterials Market Report 2022-2032 is a comprehensive assessment of the opportunities afforded by these remarkable materials and technologies. The report offers full market forecasts for nanomaterials and industrial sectors impacted by nanotechnology to 2032.

Nanotechnology and nanomaterials are key enablers for a whole new generation of products and processes with enhanced properties. Commercialized products are available from a broad range of players in markets including consumer electronics, batteries, packaging, composites, biomedicine, healthcare, and coatings.

Report contents include:

In-depth analysis of the global market for nanotechnology and nanomaterials, applications, producers, product developers and products.

Product database by market.

Assessment of nanomaterials market including production volumes, competitive landscape, commercial prospects, applications, demand by market and region, stage of commercialization, prices and producer profiles.

Examples of successful markets and products.

TRL assessment for nanomaterials and end user markets.

Ten year forecasts to 2032 on nanomaterials demand in metric tonnes.

Revenues for nanotechnology and nanomaterials by end user market to 2032.

Analysis of global trends, including historical data from 2010, and projections to 2032.

Exploration of nanomaterials and nanotech-enabled products market structures and value chains.

Assessment of end user markets for nanotechnology and nanomaterials including market drivers and trends, applications, market opportunity, market challenges and application and product developer profiles. Markets covered include adhesives, aerospace and aviation, automotive, Energy conversion, storage and generation technologies, sustainable technologies, biomedicine and healthcare, coatings & paints, composites, conductive inks, construction & buildings, cosmetics & sunscreens, electronics, photonics, filtration and environmental remediation, food and agriculture, fuel cells and hydrogen storage, household care and sanitary, lighting, lubricants, marine, oil, gas and mining, packaging, rubber, security and defence, sensors, solar, batteries, textiles and apparel, 3D printing, catalysts, thermoelectrics.

Unique assessment tools for the nanomaterials market, end user applications, economic impact, addressable markets and market challenges to provide the complete picture of where the real commercial opportunities in nanotechnology and nanomaterials are. Nanomaterials covered include metal & metal oxide nanoparticles/nanopowders, carbon nanomaterials, nanocellulose, nanoclays, dendrimers, quantum dots, other 2D materials.

Main application and product opportunities in nanotechnology and nanomaterials.

Profiles of over 1,500 nanotechnology nanomaterials producers and product developers.

Story continues

Key Topics Covered:

1 Research Methodology1.1 Technology Readiness Level (TRL)

2 Introduction2.1 Aims And Objectives Of The Study2.2 Market Definition2.2.1 Properties Of Nanomaterials2.3 Categorization Of Nanomaterials

3 The Global Market For Nanomaterials3.1 Production Of Nanomaterials3.2 Global Consumption Of Nanomaterials3.3 Aluminium Oxide Nanoparticles/Powders3.4 Antimony Tin Oxide Nanoparticles/Powders3.5 Bismuth Oxide Nanoparticles/Powders3.6 Cellulose Nanofibers3.7 Cerium Oxide Nanoparticles/Powders3.8 Cobalt Oxide Nanoparticles/Powders3.9 Copper Oxide Nanoparticles/Powders3.10 Dendrimers3.11 Fullerenes3.12 Gold Nanoparticles/Powders (Au-Nps)3.13 Graphene3.14 Iron Oxide Nanoparticles/Powders3.15 Magnesium Oxide Nanoparticles/Powders3.16 Manganese Oxide Nanoparticles/Powders3.17 Multi-Walled Carbon Nanotubes (Mwcnt)3.18 Nanoclays3.19 Nanodiamonds3.20 Nanofibers3.21 Nanosilver3.22 Nickel Nanoparticles/Powders3.23 Quantum Dots3.24 Silicon Oxide Nanoparticles/Powders3.25 Single-Walled Carbon Nanotubes (Swcnt)3.26 Titanium Dioxide Nanoparticles/Powders3.27 Zinc Oxide Nanoparticles/Powders3.28 Zirconiumoxide Nanoparticles/Powders3.29 Other Nanomaterials3.30 Other 2D Materials

4 Markets For Nanotechnology And Nanomaterials4.1 Adhesives4.1.1 Market Drivers4.1.2 Markets And Applications4.1.2.1 Properties4.1.2.2 End User Markets4.1.2.3 Nanomaterials In Adhesives4.1.3 Technology Readiness Level (TRL)4.1.4 Global Revenues To 20324.1.5 Product Developers4.2 Aerospace And Aviation4.3 Automotive4.4 Batteries4.5 Biomedicine And Healthcare4.6 Coatings And Paints4.7 Composites4.8 Conductive Inks4.9 Construction And Buildings4.10 Cosmetics And Sunscreens4.11 Electronics And Photonics4.12 Filtration4.14 Fuel Cells4.15 Household Care And Sanitary4.16 Lighting4.17 Lubricants4.18 Marine4.19 Oil, Gas And Miniing4.20 Packaging4.21 Rubber4.22 Security And Defence4.23 Sensors4.24 Solar4.25 Supercapacitors4.26 Textiles & Apparel4.27 Tools & Manufacturing4.28 3D Printing4.29 Other Markets

5 References

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/i9rd1q

Original post:
Global Nanotechnology and Nanomaterials Market Report 2022-2032 with Profiles of Over 1,500 Nanotechnology Nanomaterials Producers and Product...

Did the prevalence of gonorrhea in early humans lead to long-living and protective grandmothers? – Genetic Literacy Project

The arms race between the human immune system and gonorrhea might have had the useful side effect of promoting healthy brain tissue later in life.

This tiny boost to cognitive health in our twilight years might have played a small role in ensuring grandmas were sharp-minded enough for evolution to keep them around.

While its fiendishly difficult and may be impossible to figure out what evolutionary factors are responsible for living beyond ages where we no longer reproduce, researchers at the University of California, San Diego, are closing in on some possible explanations.

In2015, a team of researchers led by molecular medicine professor Ajit Varki discovered that humans have a unique type of immune receptor that protects againstAlzheimersdisease and sets us apart from other primates.

In apaperpublished this month, the team found that the spreading of this variant immune receptor in our species wasnt entirely random, but rather the result of intense selection pressure over a relatively brief period.

The research showed that some of our closest relatives NeanderthalsandDenisovans did not have this version of immune receptors coded into their genomes. Something drove humans to develop this special immune receptor early in our history as a species, the researchers said.

The likely culprits are infectious human-specific pathogens likeNeisseria gonorrhoeae that try to disguise themselves by dressing in the same sugar coating as human cells, which fools patrolling immune cells into thinking the bacteria are harmless.

The researchers showed that the newly evolved immune receptor could see through the disguise and kill the invading bacteria, while the older variation of the immune receptor could not.

Getting rid of gonorrhea is useful for the survival of the species because this disease can mess with human reproduction.

The new version of the immune receptor is called huCD33. Thanks to the way this version is tweaked into two subtly different structures within our body, its been the subject of investigations by evolutionary scientists for some time.

Once evolved, this immune receptor was probably co-oped by brain immune cells, called microglia, for a different purpose: protection against aging, the researchers suggest.

The human immune system usually doesnt attack itself on purpose, but it needs to when cells start to decay.

The huCD33 receptor, which seems to have evolved as a response to sneaky bacteria, had the added benefit of being able to recognize decaying brain tissue and thereby protect cognitive function in old age.

Microglia use the huCD33 receptor to clear away damaged brain cells and amyloid plaques associated with Alzheimers disease.Whether this might have played a role in clearing the way for evolution to add a few more precious years to our lives for the sake of helping out with raising families is a topic open to debate.

Grandparents provide benefits to the human species as they help to look after kids and pass on important cultural knowledge. And gonorrhea may be to thank for that.

Read the original post here

Go here to see the original:
Did the prevalence of gonorrhea in early humans lead to long-living and protective grandmothers? - Genetic Literacy Project

IS THIRD REALLY WEIRD? – Greater Kashmir

According to recent research published in journal of Human Reproduction Update, the sperm count among men is dropping and the decline is not slowing any way. Male identity is diluting in more than one way.

We find that the deep voices of men are drowning and their valor vanishing. Men are choosing to be fair, feeble and feminine. They are getting soft spoken and slimmer every day.

On the other hand, women are getting rough and robust, struggling hard to be strong not serene, to be bold not shy, to be he not she. The result is a mere exchange of identities which is neither wholesome nor original.

The girls tend to look like tom-boys and the boys are so chocolaty. Everyone is cherishing to live by choices which are beyond the scope of natural laws.

While transgender is about a natural calamity, being Lesbian or Gay or bisexual is about the personal choice of individuals. We have been transgressing the natural disposition every day. So all of us are trans in one way or the other. Much like our mobile phones, we are badly in need of a reset and restore.

When we are in search of best quality, we always mean the original taste, the original flavour, the original color, the original fruit, the original cloth of wool, cotton and leather.

A wise man was so fond of originality that he said, It is better to fail in originality than to succeed in imitation. For the transgenders, I want to end with this wise quote of Shannon L. Alder, Your dignity can be mocked, abused, compromised, toyed with, lowered and even badmouthed, but it can never be taken from you.

You have the power today to reset your boundaries, restore your image, start fresh with renewed values and rebuild what has happened to you in the past.

Read more here:
IS THIRD REALLY WEIRD? - Greater Kashmir

What I learned after meeting a Catholic nun who supports abortion rights – The Independent

Its time to reimagine the debate around abortion. We are trapped in the tyranny of a binary choice: one side sees baby murderers; the other, patriarchal dictators who want to control womens bodies. This diametrically opposed pro-life/pro-choice discourse is a closed-loop. The result: a country that is dumbed down by polarisation.

Im a millennial raised in San Francisco, pro-choice and reproductive rights might as well have been my lullabies. At 15, I darted over to my nearest Planned Parenthood health center to get birth control pills. I wasnt sexually active and I hadnt even had my first period, but I pocketed them with pride a souvenir of personal choice.

Throughout adulthood, the pro-choice/pro-life binary gave me a comfortable foothold in the abortion debate and a prefabricated enemy to address. That changed when I met Sister Teresa Forcades, a former medical doctor, theologian and Catholic nun who supports abortion rights.

In our catchphrase country, complexity is like dirty dishwater opaque and best avoided. But after the Supreme Court decision to strike down Roe v Wade, it is precisely what we need. The majority of Americans refuse to think in such absolutes when it comes to abortion. Most of us are more inclined to say it depends.

We need a common framework broad enough for the heart of the abortion debate: what does it mean to be a human with dignity?

Based in Barcelona, Spain, Sister Forcadess vocal opposition to the churchs stance on abortion has earned her the moniker Europes most radical nun. Christian fundamentalist news sites have dubbed her The Abortion Nun and The Nun of the Devil. In 2009, the Vatican sent a letter demanding she withdraw her abortion views and be disciplined (yes, even nuns risk getting cancelled!). Instead, Forcades replied with a theological argument for reproductive rights so rigorously articulated that it silenced her Catholic cohort. Thirteen years later, the Vatican is yet to respond.

But she wont be called pro-choice. She says this binary limits the possibility that she can simultaneously believe in the sanctity of life and abortion rights.

Her argument is also deceptively simple. The essence of the classic pro-life argument is that the mother who aborts a pregnancy is choosing to kill her child, and must be forced not to. But take another example: a father whose child needs a kidney transplant to survive.

She asked: Is the church ready to force the father under punishment of imprisonment, or ex-communication, to give the kidney to the child? The answer: The church is not.

It will not make the father feel that the whole rage of God is going to fall upon him if he does not offer a little bit of his body to save the life of his child. No, its not doing it. Such a practice could ideologically justify all kinds of abuses like sacrificing one person for the sake of saving a few others by distributing that persons organs, she adds.

Her argument is sound, but its the simplest detail that struck me most: the mans body. According to the Catholic church, a man doesnt have to give a kidney to his child, yet a woman (in the grip of a life-threatening pregnancy) must surrender her body to the foetus.

This role reversal and subtle push against double standards add a refreshing jolt of feminism to the abortion debate one that the original Roe v Wade decision never quite delivered. The 1973 Supreme Court ruling hinged on a pregnant persons constitutional right to privacy, which protects this individuals right to choose.

The philosopher Immanuel Kant said a human being should never be an instrument for somebody else, as that runs against our dignity. Turning a man into a machine for organ-making, for example. Likewise, Forcades says, banning abortion turns a pregnant woman into an instrument of human reproduction, violating the very thing that makes us human.

When I met her, Forcades told me: The dignity of the person is something the church has been defending for centuries; sometimes alone in very difficult contexts.

What happens when a pregnant womans dignity, or very survival, is in direct conflict with the dignity of the life she carries? Is a mothers life more or less valuable than the child who relies on her for survival? And just as importantly, is the church or state ethically equipped to make this decision?

Clearly, entering such a conversation, free of guardrails, isnt about finding answers. Its about provoking more questions. We mustnt dupe ourselves into thinking that dialogue will lead to larger shared truths or even common ground. Nor should we feel compelled to just brush things to their neat corners with the liberal catchphrase: Everyone has a right to their own opinion.

A break from the binary should, instead, be seen as an invitation to be uncomfortable the permission to say: its complicated.

Linda Freund is an independent journalist based in Spain. This article was produced with the support of the Center for Religion and Civic Culture at the University of Southern California, the John Templeton Foundation and Templeton Religion Trust. Opinions expressed do not necessarily reflect the views of these organisations

Read more:
What I learned after meeting a Catholic nun who supports abortion rights - The Independent

Smoking Tied to Higher Risk for Severe COVID-19 – HealthDay News

FRIDAY, July 29, 2022 (HealthDay News) -- Smoking is associated with a higher risk for severe COVID-19, including death, independent of sociodemographic characteristics and medical history, according to a study published online July 15 in PLOS ONE.

Ram Poudel, from the American Heart Association Tobacco Regulation Center in Dallas, and colleagues assessed how smoking affects COVID-19 severity using data from 122 hospitals participating in the Get-With-The-Guidelines COVID-19 Registry (January 2020 to March 2021). The analysis included 6,717 patients who were classified as current smokers or nonsmokers according to admission data and were propensity-matched (1:2) for age, sex, race, medical history, medications, and time frame of hospital admission.

The researchers found that patients who self-identified as current smokers had higher adjusted odds of death (adjusted odds ratio, 1.41), use of mechanical ventilation (adjusted odds ratio, 1.15), and major adverse cardiovascular events (adjusted odds ratio, 1.27). Smoking was an even stronger risk factor for death among patients who were younger (18 to 59 years), were White, or had obesity.

"The robust and significant increase in the risk of severe COVID-19 seen in our study, independent of medical history and medication use and particularly among young individuals, underscores the urgent need for extensive public health interventions such as antismoking campaigns and increased access to cessation therapy, especially in the age of COVID," a coauthor said in a statement.

Abstract/Full Text

Visit link:
Smoking Tied to Higher Risk for Severe COVID-19 - HealthDay News

Human life ‘an incredible gift from God’ that must be honored, says archbishop – CatholicPhilly.com

By Gina Christian Posted August 2, 2022

Human life is an incredible gift from God, and its sacredness and dignity, from natural conception to natural death, must be honored, said Archbishop Nelson Prez.

The archbishop shared his reflections in a homily during a July 31 Mass he celebrated at the Cathedral Basilica of SS. Peter and Paul. Sponsored by the archdiocesan Office for Life and Family (OLF), the liturgy which drew some 350 faithful was offered in thanksgiving for the gift of human life, particularly in light of a recent Supreme Court ruling that the Constitution does not confer a right to abortion.

Concelebrating the Mass with Archbishop Prez were Philadelphia Auxiliary Bishop John McIntyre; Military Archdiocese Auxiliary Bishop Joseph Coffey; Msgr. David Benz, pastor emeritus of the former St. Therese of the Child Jesus Parish in Philadelphia; and Father Dennis Gill, cathedral rector and director of the archdiocesan Office for Divine Worship; with permanent Deacon Pat Kennedy, a board member of the Pro-Life Union of Greater Philadelphia, assisting.

Quoting St. John Paul II, the archbishop said all human life must be seen in its eternal context, since man is called to a fullness of life which far exceeds the dimensions of his earthly existence, because it consists in sharing the very life of God (Evangelium Vitae, 2).

Archbishop Prez said Gods creative designs contrasted with human efforts to (play) around with life and go places we should never have gone to in the process.

We took into our hands as a society the actual defining of when life begins, and what life should look like and what life is, he said. How arrogant.

The archbishop commended faithful Christian people who had prayed for decades, in front of abortion centers and in their own parishes, that the millions and millions of abortions performed since the 1973 U.S. legalization of abortion would be halted.

The Supreme Courts June 24 decision in Dobbs v. Jackson Womens Health Organization, which overturned the 1973 Roe v. Wade precedent on abortion, represented a partial answer to those prayers, said the archbishop, who reminded faithful of his personal maxim to never underestimate the power of the Spirit of God working through you, in you and despite you.

With the issue of abortion returned to the state level, the task at hand is to connect women facing challenging pregnancies with an array of supports, said OLF director Steven Bozza.

His office provided Mass attendees with a 94-page booklet listing more than five dozen pregnancy outreaches including archdiocesan Catholic Social Services (CSS) in the Greater Philadelphia, Lehigh Valley and Lancaster areas, as well as southern New Jersey and Delaware.

This is the message we want to get out to everybody: were there for you, said Bozza. If youre in a problem pregnancy, you dont have to (go) through this alone.

Along with such resources, pro-life advocates must continue to tell the truth about pre-born children, said Bishop Coffey.

Lots of times, people say they want to follow the science for other things, and the science here is clear, he said. A ninth grader could understand this in biology class, how 23 chromosomes from the man and 23 from the woman come together. At that moment, its a human life. The day before his birth, is a baby any less a baby?

Language surrounding the abortion debate has confused that reality, said Mass attendee Deb Mirenda, a member of the Philadelphia-area Life Runners chapter and of St. Joseph Parish in Downingtown.

When people say reproductive rights once reproduction happens, that ends the conversation, because now we need a new conversation, one on the dignity of life and of another human being, said Mirenda, who has five children.

A commitment to honesty is central to evangelization and discipleship, said Father Gill, citing a quote by Jesuit Father Daniel Berrigan on Servant of God Dorothy Day: She lived the Gospel as if it were the truth.

Christine and Daniel Grimm, on hand at the Mass with their two-month-old son Peter, said the reality of a newborn child deepens the awareness of the profound and joyful gift of life.

Do not be afraid, said Daniel Grimm.

Dr. Monique Ruberu, an obstetrician and gynecologist who has been a longtime prolife advocate, urged Mass attendees to invest both spiritually and practically in the lives of those facing crisis pregnancies.

In her post-Communion remarks, Ruberu said prayer intercessors, ultrasonographers, trade and business professionals along with post-abortive women willing to share their stories of loss and healing were all vital to the task of helping to make abortion unthinkable.

Now that the Dobbs decision has been issued, Mirenda believes that a greater respect for life will gradually take hold throughout the nation.

It changes one heart at a time, one mind at a time, one person at a time, she said.

Two-month-old Peter Grimm and his parents Daniel and Christine joined faithful for a July 31 Mass of Thanksgiving for the Gift of Human Life celebrated by Archbishop Nelson Prez at the Cathedral Basilica of SS. Peter and Paul. (Gina Christian)

Original post:
Human life 'an incredible gift from God' that must be honored, says archbishop - CatholicPhilly.com

The grim realities behind barring Nancy Pelosi from Communion – Catholic Culture

By Robert G. Marshall (bio - articles - email ) | Aug 02, 2022

In what is surely an American First, the Roman Catholic Archbishop of San Francisco, His Excellency, Salvatore Cordileone, informed Nancy Pelosi, Speaker of the House of Representatives, and third in line to be President, that she is not to receive Communion, until such time as you publicly repudiate your advocacy for the legitimacy of abortion and confess and receive absolution of this grave sin in the sacrament of Penance.

The San Francisco Examiner, a very Leftist newspaper, editorialized, In open defiance of Pope Francis, San Francisco Archbishop Salvatore Cordileone on Friday banned House Speaker Nancy Pelosi from taking Holy Communion here in her home diocese. The reason? Her strong support of womens abortion rights.

Actually, Pelosi is more than just a strong supporter of abortion. Pelosi described herself at a Catholic Georgetown University meeting, I am a rabid supporter of a womans right to choose. San Francisco Archbishop Cordileone had previously alerted House Speaker Pelosi (4/7/22) that she had crossed a line by announcing that she would support codifying the Roe vs. Wade Supreme Court decision in Federal law, noting, should you not publicly repudiate your advocacy for abortion rights or else refrain from referring to your Catholic Faith in public and receiving Holy Communion, I would have no choice but to make a declaration, in keeping with canon 915, that you are not to be admitted to Holy Communion.

The timing was not political. Archbishop Cordileone had been in dialogue with the Speaker on the abortion question for at least ten years. The Archbishop said Ive been debating this within my own conscience for many years. Ive consulted with people...who would have different perspectives on the situation.... Ive done a lot of prayer and fasting.... I really would prefer not to do this. But I cannot in my conscience allow the situation to continue and cause this scandal.

Pelosi Tries to Defend Herself

Speaker Pelosi was a guest (5/24/22) on MSNBCs Morning Joe TV program hosted by former Democrat Congressman Joe Scarborough and his wife, Mika Brzezinski. Joe Scarborough asked Speaker Pelosi, ...what do you say to Catholics who see whats happening to you...why you have an archbishop taking a step like this?

Pelosi claimed that Archbishop Cordileone, in denying her Holy Communion, was not consistent with the Gospel of Matthew, which she identified as the agenda of the Church. However, the Gospel of Matthew undermines Pelosis case as it states (18:1517) If your brother or sister sins, go and point out their fault, just between the two of you. If they listen to you, you have won them over. But if they will not listen, take one or two others along, so that every matter may be established by the testimony of two or three witnesses. If they still refuse to listen, tell it to the church.

Pelosi questioned the consistency of Archbishop Cordileone in denying Communion to Catholic public officials for abortion support, but not for death penalty support. I wonder about death penalty, which Im opposed to. So is the Church, but they take no action against people who may not share their view. But in 2004, Cardinal Ratzinger , writing specifically on the question of Catholic politicians who support the death penalty noted:

When Pope Francis modified the Catholic Catechism to say capital punishment should not be used, he did not state that the death penalty was ever lacking in justice or that it was evil in itself, as popes have said about abortion for centuries.

Cardinal Ladaria, who heads the Congregation for the Doctrine of the Faith, and therefore speaks for Pope Francis, sent a letter (8/1/18) to the U. S. Catholic Bishops explaining Franciss death penalty change: the death penalty...can be justified if it is the only practicable way to defend the lives of human beings effectively against the aggressor, even if in reality cases of absolute necessity for suppression of the offender today are very rare, if not practically non-existent. (n. 2267).

One commentator noted that while Pope Francis teaches the death penalty is, no longer admissible as a general norm...it is not infallible; and therefore, it does not require the assent of divine faith on the part of the faithful....the new formulation of...the Catechism...desires...respectful dialogue with civil authorities, to encourage the creation of conditions that allow for the elimination of the death penalty where it is still in effect.

Pelosis Catalog of Abortion Support

MSNBC Morning Joe co-host, Mika Brzezinski referred to recent Senate action on the grossly misnamed Womens Health Protection Act (WHPA) (S 4132) which most assume codifies Roe. Neither the Senate (S 4132) nor the House version (HR 3755) of the morally grotesque Womens Health Protection Act merely codify the 1973 Roe v. Wade decision. Both versions of the bill expand abortion way beyond Roe.

The Catholic Bishops Secretariat for Pro Life Activities compiled a list of present federal court approved state or federal laws legal even under Roe v. Wade . All of these current state and federal provisions would be illegal under Pelosis WHPA pro abortion legislation:

Nancy PelosiAbolishing Catholic-Christian Health Care

The Charlotte Lozier Institute notes that private Christian health care is especially undermined under the Womens Health Care Protection Act from 2019, H. R. 2975. Law Professor and religious freedom expert Mark Rienzi points out that virtually every state in the country has some sort of statute protecting individuals and, in many cases, entities who refuse to provide abortions and [s]ome states expressly limit this protection to the practice of abortion, which is treated specially. Moreover:

H. R. 3755, the current House version of the Womens Health Protection Act, could have been written by Karl Marx or Vladimir Lenin. Pelosis bill states, Abortion-specific restrictions are a tool of gender oppression. The findings section on page 3 of HR 3755, which judges are supposed to reference to determine the meaning of the text of the statute states:

Pelosis affirmation that reproductive rights belong to all individuals to define and make decisions about their bodies, health, sexuality, will make statutory rape and consent laws illegal in all fifty states and US Territories. This is a goal of abortionists and transgender zealots. Pregnancy from artificial reproduction outside the womb or marriage will become a right of individuals, threesomes, etc.

Pelosis radical policy is miles beyond codifying Roe v. Wade and she certainly knows that. Under Pelosis bill, LGBTQ+ persons would have a right to an abortion and to demand under a surrogacy pregnancy contract that a surrogate mother would be required to abort a child for any reason if the owners of the child were not satisfied. Note also that while Abortion services is defined in Section 3 under definitions, Abortion is not defined anywhere in the bill. Section 3 on page 16 states, The term pregnancy refers to the period of the human reproductive process beginning with the implantation of a fertilized egg. The end of pregnancy is not defined.

A legislator who wanted to authorize infanticide but who did not want use the word, could employ that verbal tactic. Further, H. B. 3755 (Section 7, page 24) contains a Rule of Construction which allows no government interference, with a persons ability to terminate a pregnancy, to diminish or in any way negatively affect a persons constitutional right to terminate a pregnancy. Other Findings on page 2 state, Since 1973, the Supreme Court repeatedly has recognized the constitutional right...to terminate a pregnancy after fetal viability....

The Churchs Response to Pelosi, and Pelosis Response to the Church

The San Francisco Examiner (5/21/22), eager to defend Pelosis self-affirming and contrived Catholic Faith, used inflammatory words to tag Archbishop Cordileone as an insubordinate saboteur acting in open defiance of Pope Francis for ruling that Speaker Pelosi is ineligible to receive Holy Communion.

But Cardinal Luis Ladaria , Prefect for the Congregation for the Doctrine of the Faith, suggested to Los Angeles Archbishop Jose Gomez (5/7/21), President of the USCCB, that if the bishops wanted to establish nationwide standards relating to abortion-supporting Catholic politicians, the bishops should undertake a two-stage dialogue, first among the bishops themselves, and then between bishops and Catholic pro-choice politicians within their jurisdictions. Such a national policy on worthiness to receive Communion, should be applied to all the faithful, rather than one category of Catholics.

Pope Francis was cited in the Tablet (5/23/22):

In many respects, the Popes actions regarding Catholic politicians Pelosi and Biden have been disappointing. U. S. Pro Life Bishops Chairman Archbishop Naumann (Kansas City, Kansas) stated that the Pope does not understand the Church in the United States, and he also noted that when the Pope publicly received Pelosi, the meeting was politically exploited. In allowing this, Pope Francis is doing exactly what he warns others not to do. During a recent papal interview with Spanish language Univision the Pope was asked about Nancy Pelosis reportedly receiving Communion in Mass at St. Peters, despite Archbishop Cordileones barring Pelosi from Communion. Pope Francis noted that Pelosi continues to receive the Eucharist in Washington, D. C. as well.

Yet during the interview, the Pope described Bidens abortion position as an incoherence with the Catholic Faith. Archbishop Naumann commented in the National Catholic Register , Its very helpful because I think thats exactly true, that his (Bidens) position is incoherent with Catholic teaching. So Im grateful for that clarification by the Holy Father. We must pray that actions will follow the Holy Fathers words.

In June, 1990 the New York Times reprinted excerpts of comments made by John Cardinal OConnor in his New York Archdiocese newspaper:

Pelosi responded: There is no desire to fight with the cardinals or archbishops.... But it has to be clear that we are elected officials, and we uphold the law and we support public positions separate and apart from our Catholic Faith. Yet, she also claims that her abortion votes are compatible with her Catholic Faith.

Some of Pelosis Faith-based claims about abortion being consistent with her Faith are linked below:

After one of Speaker Pelosis I am a Catholic and support abortion interviews on Meet the Press with Tom Brokaw (8/24/08) Speaker Pelosi was rebuked by Denver Archbishop Charles Chaput: Catholic public leaders inconvenienced by the abortion debate...seem comfortable in the role of theologian.... The Christian tradition from the earliest days reveals a firm anti-abortion attitude The condemnation of abortion did not depend on and was not limited in any way by theories regarding the time of fetal animation.

Pelosi Claims to Not Impose Her Views on Others

Nancy Pelosi claimed on the Morning Joe program (5/24/22) that, I come from a largely pro-life, Italian-American, Catholic family, so I respect peoples views about that. But I dont respect us foisting it onto others.

However, Speaker Pelosi foisted her pro-abortion views on others by strongly supporting and voting for H. R. 5, the so-called Equality Act, promoted by homosexual activists who seek to impose their radical demands on individuals and institutions governed by the morals of Moses and Jesus. Pelosis misnamed Equality Act will compel doctors and health care institutions to perform abortions and sex-change operations, and furnish puberty blockers for minors or lose their medical licenses or accreditation.

Private conscience and religious rights are presently protected under various Federal and State conscience laws which exempt doctors, nurses and health care establishments from having to comply with such immoral practices, but Speaker Pelosi wants to strip away all conscience and privacy protections for girls and women, and destroy female sports. Under Pelosis alleged Equality Act, a person, business, church, private school or religious group that does not comply with or support the LGBTQ+ agenda will be charged with discriminating under the Civil Rights Act, equal to violating the civil rights of African Americans. Fines can be $500,000 per incident depending upon the size of the organization accused of discriminating.

Background Resources

Archbishop Cordileone wrote a succinct, well-reasoned letter to Speaker Pelosi. The Archbishops second letter explains to Catholics in the San Francisco Archdiocese (and beyond) how he reached his decision. His third letter was sent to priests in which he details the Canon law background for his decision, with which priests and deacons must comply. Interestingly, the very liberal Jesuit America magazine had an excellent, thorough interview with Archbishop Cordileone hosted by Gloria Purvis, available as a podcast and a shorter print version.

Bishops honoring Archbishop Cordileones Communion directive regarding denial of Holy Communion for Speaker Pelosi include as of May 24, 2022 (source: National Catholic Register):

Recent Abortion Votes in Congress

To find out which Members of the House of Representatives and the Senate voted for the their respective versions of the Womens Health Protection act, go the following links.

Did your Catholic member of Congress vote in favor of this abortion legislation? St. Paul (1 Timothy 2:14) urges us to pray for those in authority. In addition to praying, we should make immoral positions known to others, and vote in every special, primary and general election only for pro-life candidates. Now that the Supreme Court has overturned Roe we must work to convince state legislatures to pass legislation to secure legal protection for the lives of all innocent children before birth.

Bob Marshall served 26 years in the Virginia House of Delegates and was the chief House sponsor of the 2006 voter-approved Virginia Marriage Amendment and a ban on late term abortion. He recently wrote Reclaiming the Republic: How Christians and Other Conservatives Can Win Back America (TAN Books). Previously, he co-authored Blessed are the Barren, a social history of Planned Parenthood (Ignatius Press). Finally, dont miss Bobs Civics Lesson for Catholics in the Catholic Culture Podcast Episode 17. See the full bio.

Sound Off! CatholicCulture.org supporters weigh in.

All comments are moderated. To lighten our editing burden, only current donors are allowed to Sound Off. If you are a current donor, log in to see the comment form; otherwise please support our work, and Sound Off!

See the article here:
The grim realities behind barring Nancy Pelosi from Communion - Catholic Culture

An easier and safer way to synthesize medicines – The Ohio State University News

Despite being some of the most versatile building blocks in organic chemistry, compounds called carbenes can be too hot to handle. In the lab, chemists often avoid using these highly reactive molecules due to how explosive they can be. Yet in a new study, published today in the journal Science, researchers from The Ohio State University report on a new, safer method to turn these short-lived, high-energy molecules from much more stable ones.

Carbenes have an incredible amount of energy in them, said David Nagib, co-author of the study and a professor of chemistry and biochemistry at Ohio State. The value of that is they can do chemistry that you just cannot do any other way.

In fact, members of the Nagib Lab specialize in harnessing reagents with such high chemical energy, and have helped invent a multitude of new substances and techniques that would otherwise be chemically unobtainable.

In this study, the researchers developed catalysts made out of cheap, Earth-abundant metals, like iron, copper and cobalt, and combined them to facilitate their new method of harnessing carbene.

They were able to successfully use this new strategy to channel the power of reactive carbenes to fabricate valuable molecules on a larger scale and much more quickly than traditional methods. Nagib compared this leap to engineers figuring out how to use steel to build skyscrapers rather than brick and mortar.

For instance, one molecular feature that chemists have been hard-pressed to create is cyclopropane, a small, strained ring of twisted chemical bonds found in some medicines. More recently, cyclopropane has been used as a key ingredient in the oral antiviral pill called Paxlovid. Used to treat COVID-19, the pill reduces the severity of the disease by stopping the virus from replicating, rather than killing it outright.

Although the cyclopropane needed to fabricate the drug has been difficult to create in large quantities, Nagib said he believes his labs new method could be applied to create the drug more quickly and at a larger scale. Our new method will enable better access to dozens of types of cyclopropanes for incorporation into all kinds of medicines to treat disease, he said.

While the teams research does have potential applications outside the pharmaceutical realm, like agrochemicals, Nagib said hes most passionate about how their tool could speed up the discovery of new, targeted medicines. You could technically apply our methods to anything, he said. But in our lab, we're more interested in accessing new types of more potent drugs.

Nagib predicts that, using the process his team developed, a chemical reagent that currently takes 10 or 12 steps to make (by explosive intermediates) could be done in four or five, knocking off nearly 75% of the time it takes to fabricate.

Overall, Nagib said he hopes this research will help other chemists do their work.

There are lots of really great scientists around the world who do this kind of chemistry and using our tool they could potentially have a safer lab, Nagib said. The flavor of science that we do, the most satisfying reward is when other people use our chemical methods to make important molecules better.

Other co-authors were Lumin Zhang, a former postdoctoral fellow, as well as Bethany M. DeMuynck, Alyson N. Paneque and Joy E. Rutherford, all graduate students in the department of chemistry and biochemistry and members of the Nagib Lab. The research was supported by the National Institutes of Health, the National Science Foundation and the Sloan Foundation.

See the rest here:
An easier and safer way to synthesize medicines - The Ohio State University News

Enzyme, proteins work together to tidy up tail ends of DNA in dividing cells – University of Wisconsin-Madison

Researchers at the University of WisconsinMadison have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new insight into how a human cell preserves the integrity of its DNA through repeated cell division.

DNA replication is essential for perpetuating life as we know it, but many of the complexities of the process how myriad biomolecules get where they need to go and interact over a series of intricately orchestrated steps remain mysterious.

From left, Qixiang He, Ci Ji Lim, Xiuhua Lin.

The mechanisms behind how this enzyme, called Pol-primase, works have been elusive for decades, says Ci Ji Lim, an assistant professor of biochemistry and principal investigator on new research into DNA replication published recently in Nature. Our study provides a big breakthrough in understanding DNA synthesis at the ends of chromosomes, and it generates new hypotheses about how Pol-primase a central cog in the DNA replication machine operates.

Every time a cell divides, the telomeres at the end of the long DNA molecule that makes up a single chromosome shorten slightly. Telomeres protect chromosomes like an aglet protects the end of a shoelace. Eventually, the telomeres are so short that vital genetic code on a chromosome is exposed and the cell, unable to function normally, enters a zombie state. Part of a cells routine maintenance includes preventing excessive shortening by replenishing this DNA using Pol-primase.

At the telomere construction site, Pol-primase first builds a short nucleic acid primer (called RNA) and then extends this primer with DNA (then called RNA-DNA primer). Scientists thought Pol-primase would need to alter its shape when it switches from RNA to DNA molecule synthesis. Lims lab found that Pol-primase makes the RNA-DNA primer at telomeres using a rigid scaffold with the help of another cog in the telomere replication machine, an accessory protein called CST. CST acts like a stop-and-go sign that halts the activity of other enzymes and brings Pol-primase to the construction site.

Before this study, we had to imagine how Pol-primase works to complete telomere replication at the ends of chromosomes, says Lim. Now, we have high-resolution structures of Pol-primase bound to an accessory protein complex called CST. We found that after CST binds to the template DNA strand at the telomere, it facilitates the action of Pol-primase. In doing so, CST sets the stage for Pol-primase to first synthesize RNA and then DNA using a unified architectural platform.

The researchers also got a glimpse into how Pol-primase might initiate DNA synthesis elsewhere along the length of a chromosome. Other scientists have also found the CSTpol--primase complex at sites where DNA damage is being repaired and where DNA replication has stalled.

Because Pol-primase plays a central and very important role in DNA replication in telomeres and elsewhere along chromosomes its the only enzyme that makes primers on DNA templates from scratch for DNA replication our CSTPol-primase structure provides new insights into how Pol-primase can also do its job during genomic DNA replication, Lim says. Its a very elegant solution that nature has evolved to accomplish this complicated process.

Our findings reveal an unprecedented role that CST plays in facilitating this Pol-primase activity, explains first author Qixiang He, a graduate student in the UWMadison biophysics graduate program. It will be interesting to see if accessory factors involved in DNA replication elsewhere on chromosomes set up Pol-primase the same way as CST does for telomeres.

The researchers built the structural model of CSTPol-primase using an advanced imaging technique called cryo-electron microscopy single-particle analysis. In cryo-EM, rapidly frozen samples are suspended in a thin film of ice, then imaged with a transmission electron microscope, resulting high-resolution, 3D models of biomolecules like the enzymes at work in DNA replication.

Lims team used cryo-EM single particle analysis to first determine the structure of CSTPol-primase and then home in on visualizing moving parts of the complex in greater detail. They collected data at the UWMadison Cryo-Electron Microscopy Research Center (CEMRC), housed in the UWMadison Department of Biochemistry, and the NCI-funded National Cryo-Electron Microscopy Facility at the Frederick National Laboratory for Cancer Research.

We started with a conundrum from our biochemical assay, but once we imaged the CSTpol--primase co-complex and saw its cryo-EM structures, everything immediately became clear. This was extremely satisfying for everyone on the team. Beyond that, the structures also provide ideas that we can now design experiments to test, says Xiuhua Lin, lab manager and co-author of the new study.

Among these ideas are capturing how CSTpol-/primase works in more detail. The researchers also want to map the entire human telomere replication process, and theyre studying how CSTpol-/primase terminates its activity once the DNA at telomeres is copied.

You cant really study how a car moves by looking at its individual parts you have to assemble the parts and observe how they work together. But biomolecular machinery often has so many moving parts that it can be difficult to study, Lim says. Thats where the power and versatility of cryo-electron microscopy single-particle analysis come in. This approach allowed us to put together a high-resolution atomic model and provided critical insights into how it moves, which in turn facilitated our understanding of how the human CSTPol-primase works.

The research was supported by a grant from the National Institutes of Health (R00GM131023).

Continue reading here:
Enzyme, proteins work together to tidy up tail ends of DNA in dividing cells - University of Wisconsin-Madison

In DNA, scientists find solution to building superconductor that could transform technology – EurekAlert

image:Edward H. Egelman, PhD, of the University of Virginia School of Medicine's Department of Biochemistry and Molecular Genetics, has been a leader in the field of cryo-electron microscopy (cryo-EM), and he and his colleagues used cryo-EM imaging for this seemingly impossible project. It demonstrates, he said, that the cryo-EM technique has great potential in materials research. view more

Credit: Dan Addison | UVA Communications

Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics.

One possible outcome of such engineered materials could be superconductors, which have zero electrical resistance, allowing electrons to flow unimpeded. That means that they dont lose energy and dont create heat, unlike current means of electrical transmission. Development of a superconductor that could be used widely at room temperature instead of at extremely high or low temperatures, as is now possible could lead to hyper-fast computers, shrink the size of electronic devices, allow high-speed trains to float on magnets and slash energy use, among other benefits.

One such superconductor was first proposed more than 50 years ago by Stanford physicist William A. Little. Scientists have spent decades trying to make it work, but even after validating the feasibility of his idea, they were left with a challenge that appeared impossible to overcome. Until now.

Edward H. Egelman, PhD, of UVAs Department of Biochemistry and Molecular Genetics, has been a leader in the field of cryo-electron microscopy (cryo-EM), and he and Leticia Beltran, a graduate student in his lab,used cryo-EM imaging for this seemingly impossible project. It demonstrates, he said, that the cryo-EM technique has great potential in materials research.

Engineering at the Atomic Level

One possible way to realize Littles idea for a superconductor is to modify lattices of carbon nanotubes, hollow cylinders of carbon so tiny they must be measured in nanometers billionths of a meter. But there was a huge challenge: controlling chemical reactions along the nanotubes so that the lattice could be assembled as precisely as needed and function as intended.

Egelman and his collaborators found an answer in the very building blocks of life. They took DNA, the genetic material that tells living cells how to operate, and used it to guide a chemical reaction that would overcome the great barrier to Littles superconductor. In short, they used chemistry to perform astonishingly precise structural engineering construction at the level of individual molecules. The result was a lattice of carbon nanotubes assembled as needed for Littles room-temperature superconductor.

This work demonstrates thatordered carbon nanotube modification can be achieved by taking advantage of DNA-sequence control over the spacing between adjacent reaction sites, Egelman said.

The lattice they built has not been tested for superconductivity, for now, but it offers proof of principle and has great potential for the future, the researchers say. While cryo-EM has emerged as the main technique in biology for determining the atomic structures of protein assemblies, it has had much less impact thus far in materials science, said Egelman, whose prior work led to his induction in the National Academy of Sciences, one of the highest honors a scientist can receive.

Egelman and his colleagues say their DNA-guided approach to lattice construction could have a wide variety of useful research applications, especially in physics. But it also validates the possibility of building Littles room-temperature superconductor. The scientists work, combined with other breakthroughs in superconductors in recent years, could ultimately transform technology as we know it and lead to a much more Star Trek future.

While we often think of biology using tools and techniques from physics, our work shows that the approaches being developed in biology can actually be applied to problems in physics and engineering, Egelman said. This is what is so exciting about science: not being able to predict where our work will lead.

Findings Published

The researchers have published their findings in the journal Science. The team consisted ofZhiwei Lin, Leticia Beltran, Zeus A. De los Santos, Yinong Li, Tehseen Adel, Jeffrey A Fagan, Angela Hight Walker, Egelman and Ming Zheng.

The work was supported bythe Department of CommercesNational Institute of Standards and Technology and by National Institutes of Health grant GM122510, as well as by an NRC postdoctoral fellowship.

To keep up with the latest medical research news from UVA, subscribe to theMaking of Medicineblog at http://makingofmedicine.virginia.edu.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Here is the original post:
In DNA, scientists find solution to building superconductor that could transform technology - EurekAlert

Summer Scholars leave Duke with a once-in-a-lifetime research experience – Duke University

The Summer Scholars Program in Genome Sciences & Medicine, a collaboration between the Duke Program in Precision Medicine, the Duke Center for Genomic and Computational Biology (GCB), andNorth Carolina Central University (NCCU), concluded the 10-week program last week in Durham, North Carolina.

This summer, eight scholars from across the country were paired with a faculty research mentor to learn laboratory skills, designing a research project, and effectively presenting future research.

This summer program has provided me with the skills I need for the rest of my research career, said Paola J. Maldonado, a rising sophomore from the University of Puerto Rico. Working in research is what I want to do, and this experience really solidified that for me. Maldonado was mentored by Jen-Tsan Ashley Chi, PhD, associate professor of molecular genetics and microbiology and assistant professor of medicine in the division of rheumatology and immunology.

Brielle-Anne Michel, a rising junior at Wake Forest University studying biochemistry and molecular biology, was mentored by HiroakiMatsunami, PhD, professor of molecular genetics and microbiology and neurobiology at Duke. The most exciting part of this program was getting to work with the scientific technologies Ive learned about in undergrad classes but havent seen firsthand, she said. I had mentorsshow me the steps to take, and I was able to do several trials completely by my myself, which was exciting.

Students experienced 10 weeks of everything from working in labs, weekly seminars with Duke professors and graduate student mentors, and tips on networking. Among the many skills obtained, they learned more about how to form research abstracts, posters, writing personal statements and CVs, and presenting their research effectively.

The Summer Scholars program gave me my first opportunity to do hands-on research, said Sydney Vander, a pre-med chemistry major at Xavier University of Louisiana. Thanks to this program, I was able to develop important skills, such as, critical thinking, problem solving, and effective communication. Vander aspires to be a physician and shared how the Summer Scholars program helped her realize that she can incorporate research into her future career path. One day she hopes to perform clinical research while also providing care for patients.

The Summer Scholars Program in Genome Sciences & Medicine is supported by an R25 grant by the National Human Genome Research Institute at NIH and is designed for full-time first- and second-year underrepresented in STEMstudents at any college or university.

A special thanks to 2022 faculty mentors, Ashley Chi, PhD; Ornit Chiba-Falek, PhD; Lindsey Constantini, PhD (NCCU); Charlie Gersbach, PhD; Paul Magwene, PhD; Alex Marshall, PhD (NCCU); Hiro Matsunami, PhD; and Anne West, MD, PhD

Learn more about the Summer Scholars Program in Genome Sciences & Medicine

View all photos from the Summer Scholars Poster Session on July 29, 2022

See original here:
Summer Scholars leave Duke with a once-in-a-lifetime research experience - Duke University

Why You Should Pat Ribs Dry Before Cooking Them – Tasting Table

Removing the excess moisture from the ribs before cooking will do a few things. Even if your ribs are marinating, it is advised to pat them dry to help prior to cooking. According to the Kitchn, using paper towels to pat the meat dry increases the contact the meat has with the pan or grill and reduces the amount of steam created while cooking. This steam will, in turn, stop the meat from browning properly. Without it though, ribs will be able to create a delicious crust, adding additional flavors and aromas, due to the Maillard reaction.

Joseph Provost, a chemistry and biochemistry professor at the University of San Diego, told The Washington Post thatmeat should be as dry as possible before cooking so that the energy created by the heat can go straight to the food instead of evaporating moisture. This science holds true for ribs. Amazing Ribs notes to always ensure meat is dry before cooking for this very reason. Not only do they have to be pat dry before, but marinating and basting can also prevent the ribs from browning.

So, next time you're cooking up some ribs, be sure to grab a kitchen towel or a roll of paper towels; you don't want to forget this important step for the ultimate flavor.

Read more from the original source:
Why You Should Pat Ribs Dry Before Cooking Them - Tasting Table

Provost honours 33 professors with Distinguished awards – McGill Reporter – McGill Reporter

McGill has bestowed internal recognition awards on three cohorts of McGill professors. Nine senior scholars received James McGill Professor (JMP) awards. Thirteen tenure-track assistant or associate professors received William Dawson Scholar (WDS) awards, five for a second five-year term. Eleven scholars became Distinguished James McGill Professors (DJMP)McGills highest honourawarded to late-career scholars whose work exemplifies excellence and international leadership.

McGill is home to outstanding scholars doing excellent research on some of the worlds greatest challenges. Each year, I am honoured to congratulate the winners of the WDS, JMP and DJMP awards and to spotlight the research leadership of these highly accomplished individuals, said Christopher Manfredi, Provost and Vice-Principal (Academic). My sincere congratulations to all the honourees.

Among those who received the Distinguished James McGill Professor award are Dr. Louise Pilote of the Faculty of Medicine and Health Sciences, and Gregory Dudek of the Faculty of Science. A leader in womens cardiovascular health research, Dr. Pilote was recently appointed as Deputy Director of the Research Institute of the McGill University Health Centre (RI-MUHC). Professor Dudek is a globally recognized expert in AI and robotics who serves as vice-president of research at Samsung Electronics and leads the Samsung AI Center Montral, which recently doubled the size of its state-of-the-art facility and increased its team of research scientists.

The James McGill Professor awardees in 2022 include Bioresource Engineering Professor Valrie Orsat, an internationally-recognized expert in the development of functional foods, also known as nutraceuticals, in efforts to address global food security and safety challenges. Last year she received an Engineering and Physical Sciences Suffrage Science award for research excellence and for her role as a mentor for women entering the field. Another JMP awardee is Martin Schmeing, a professor in the Department of Biochemistry, who in 2020 co-led the team that developed a McGill-made version of the RT-PCR (reverse transcription polymerase chain reaction) test for COVID-19, the gold standard for identifying infections. The team produced over 15,000 tests for use by the MUHC testing facility and then set an ambitious goal to provide millions of RT-PCR tests to the Canadian government.

The William Dawson Scholar(WDS) award recognizes a scholar developing into an outstanding and original researcher who is poised to become an internationally recognized leader in their field. Among the newly appointed WDS awardees is Wendell Nii Laryea Adjetey whose first monograph, Cross-Border Cosmopolitans: The Making of a Pan-African North America, published this year, stems from his doctoral dissertation which won Yale Universitys Edwin M. Small Prize for outstanding contribution to U.S. history, Sylvia Ardyn Boone Prize for African American Studies, the Canadian Studies Prize, and the Willard Woody Brittain, Jr. Award. The book situates fundamental questions of twentieth-century U.S. historyimmigration, civil rights, racial identity, radicalism, surveillance and state powerwithin a North American diasporic frame.

Both the JMP and WDS awards come with an annual salary supplement and an annual research allowance not exceeding $25,000. The Distinguished James McGill Professor award provides for a $10,000 academic stipend or a $15,000 research grant allowance. DJMPs have held James McGill Professorships for two seven-year terms while maintaining an outstanding research record, or have held a Canada Research Chairs (Tier 1) for two seven-year terms. DJMP awardees hold the distinction until retirement, and those granted Emeritus status retain the title.

The 2022 DJMP, JMP and WDS cohort:

Distinguished James McGill Professors 11 honourees:

James McGill Professors 9 honourees:

William Dawson Scholar 13 honourees:

A current listing of all DJMP, JMP and WDS awardees:

Read the original post:
Provost honours 33 professors with Distinguished awards - McGill Reporter - McGill Reporter

Newly identified compound binds to Shiga toxin to reduce its toxicity – EurekAlert

image:Researchers from Japan used a peptide-based pharmacophore to identify a potent molecule that binds to and inhibits the bacterial Shiga toxin, Stx2a. Results suggest that the novel compound #6 may be an effective therapeutic agent against enterohemorrhagic E. coli (EHEC) infections. view more

Credit: Image credit: Prof. Kiyotaka Nishikawa from Doshisha University, JapanImage link: https://www.nature.com/articles/s41598-022-15316-1

A strain of E. coli bacteria called enterohemorrhagicE. coli(EHEC) is known to cause several gastrointestinal disorders, which include bloody diarrhea and abdominal cramps, by damaging the intestinal lining. When accompanied with fatal systemic complications, it can even cause acute renal failure in children. The EHEC exerts these deadly effects by producing the Shiga toxin (Stx), of which the Stx2a subtype is particularly virulent and deadly. Compounds that can inhibit these toxins are, therefore, desirable as potential therapeutics against EHEC infections.

To this end, a group of scientists from Japan led by Professor Kiyotaka Nishikawa from Doshisha University has recently discovered a molecule that inhibits Stx2a toxicity by binding to its A-subunit - the part of the toxin responsible for its lethality.

The catalytic A-subunit of Stx2a toxin inhibits protein synthesis and its inhibition could be crucial for slowing EHEC pathogenesis, says Prof. Nishikawa, explaining their motivation behind the study, which waspublished inScientific Reports. The same group had earlier developed an inhibitory molecule that can bind to the B-subunit of Shiga toxin and reduce its toxicity.

Professor Nishikawa and his colleagues, including Assistant Professor Miho Watanabe-Takahashi of Doshisha University, Dr. Miki Senda and Dr. Toshiya Senda of the Institute of Materials Structure Science at High Energy Accelerator Research Organization (KEK), and Dr. Kentaro Shimizu of the University of Tokyo, among others, identified the potent compound from a database with over 7,400,000 molecules.

To do this, the researchers had to first identify the basic 3D arrangement of molecules (the peptide motif) that can occupy the catalytic cavity in the A-subunit. In a stroke of luck, they stumbled upon a synthetic molecule with a high affinity for A-subunit. This molecule, a peptide called MMA-mono, helped identify the compound that could bind to the A-subunit of Shiga toxin by serving as a template.

The researchers next outlined the molecular and electronic structure that a possible inhibitory compound must have using structural analysis and X-ray crystallography. These features of a potential inhibitor, known as a pharmacophore, was then confirmed using molecular dynamics simulations.

Finally, they screened a chemical database for compounds that resembled the pharmacophore and identified nine candidates using docking simulations. Of these, a compound identified as compound #6 showed effective binding to the A-subunit of Stx2a.

Further, in vitro cytotoxicity assays using Vero cells showed that compound #6 significantly reduced the destruction of cells caused by Stx2a. Additionally, mice models treated with a lethal dose of Stx2a and compound #6 survived longer than those injected with only Stx2a.

Prof. Nishikawa is optimistic about the future applications of this study. On being asked how the compound might work in the infected cells, he explains, The hydrophobicity of compound #6 may facilitate penetration through the cell envelope, allowing it to inhibit the toxin present in the cells. We believe that it holds promise as a novel therapeutic agent for treating EHEC infections.

The team has even suggested that their studied pharmacophore could help design more inhibitors for similar toxins, such as the bioterrorism agent ricin, whose catalytic region has a structure similar to that of Stx.

We can certainly expect some new developments in the treatment of intestinal diseases caused by bacteria!

About Assistant Professor Miho Watanabe-Takahashi from Doshisha University, JapanDr. Miho Watanabe-Takahashi is an Assistant Professor at the Faculty of Life and Medical Sciences in the Department of Medical Life Systems at Doshisha University. She received her Ph.D. from Hoshi University, Japan, in 2006. She works primarily in Life Sciences and Pharmacology with a focus on health and biochemistry. She has 24 peer-reviewed publications in reputed journals and holds several industrial property rights. Her major research interests include Shiga toxin, Endoplasmic Reticulum, Golgi Complex and Pleckstrin Homology Domain.

About Professor Kiyotaka Nishikawa from Doshisha University, JapanDr. Kiyotaka Nishikawa is a Professor at the Faculty of Life and Medical Sciences in the Department of Medical Life Systems at Doshisha University. He received his Ph.D. from The University of Tokyo, Japan in 1989. He works primarily in Life Sciences and Pharmacology with a focus on health and biochemistry. He has more than 33 years of experience as a researcher and has 56 publications in peer-reviewed international journals. He also holds several industrial property rights.

Media contact:Organization for Research Initiatives & DevelopmentDoshisha UniversityKyotanabe, Kyoto 610-0394, JAPANE-mailjt-ura@mail.doshisha.ac.jp

Scientific Reports

Experimental study

Animals

A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin

6-Jul-2022

The authors declare no competing interests.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Read the original:
Newly identified compound binds to Shiga toxin to reduce its toxicity - EurekAlert