COVID-19 Daily Update 7-15-2020 – 10 AM – West Virginia Department of Health and Human Resources

TheWest Virginia Department of Health and Human Resources (DHHR)reports as of 10:00 a.m., on July 15, 2020, there have been 215,450total confirmatorylaboratory results received for COVID-19, with 4,463 totalcases and 97 deaths.

In alignment with updated definitions fromthe Centers for Disease Control and Prevention, the dashboard includes probablecases which are individuals that have symptoms and either serologic (antibody)or epidemiologic (e.g., a link to a confirmed case) evidence of disease, but noconfirmatory test.

CASESPER COUNTY (Case confirmed by lab test/Probable case):Barbour(23/0), Berkeley (530/19), Boone (42/0), Braxton (5/0), Brooke (31/1), Cabell(196/7), Calhoun (4/0), Clay (13/0), Fayette (86/0), Gilmer (13/0), Grant(20/1), Greenbrier (74/0), Hampshire (45/0), Hancock (43/3), Hardy (47/1),Harrison (128/0), Jackson (148/0), Jefferson (254/5), Kanawha (430/12), Lewis(22/1), Lincoln (10/0), Logan (40/0), Marion (113/3), Marshall (69/1), Mason(26/0), McDowell (12/0), Mercer (63/0), Mineral (68/2), Mingo (29/2),Monongalia (604/14), Monroe (14/1), Morgan (19/1), Nicholas (19/1), Ohio(151/0), Pendleton (16/1), Pleasants (4/1), Pocahontas (37/1), Preston (84/21),Putnam (91/1), Raleigh (81/3), Randolph (191/2), Ritchie (2/0), Roane (12/0),Summers (2/0), Taylor (22/1), Tucker (7/0), Tyler (10/0), Upshur (31/2), Wayne(128/1), Webster (1/0), Wetzel (37/0), Wirt (6/0), Wood (185/9), Wyoming (7/0).

As case surveillance continues at thelocal health department level, it may reveal that those tested in a certaincounty may not be a resident of that county, or even the state as an individualin question may have crossed the state border to be tested.

Pleasenote that delays may be experienced with the reporting of information from thelocal health department to DHHR.

Please visit thedashboard at http://www.coronavirus.wv.gov for more detailed information.

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COVID-19 Daily Update 7-15-2020 - 10 AM - West Virginia Department of Health and Human Resources

Millennials, teens are Utah’s biggest sources of COVID-19 infections, and the state hasn’t been able to stop that – Salt Lake Tribune

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So 16-year-old Zander was careful to not contract the virus until he wasnt.

The teen acknowledged Friday that he got lax about social distancing. He started hanging around more of his friends. They showed symptoms first. Then Zander felt sick.

He got word of his test result July 9. He has COVID-19.

I dont think we were really worried about it, Zander said, until one of our friends actually got it.

People ages 15 to 44 account for about 60% of Utahs coronavirus cases, according to the state health department. Lowering their infection rates would mark a major victory in reducing the spread, but Utah has seen little if any success in trimming those numbers.

While new cases among Utahns between ages 25 and 44, essentially millennials, have declined as a percentage of new infections, that trend has been offset by new infections among teens and those in their early 20s, who since schools let out in the spring have become the biggest source of new cases on a per 100,000 population basis.

Through their lens, it is not a serious disease, said Sue Jackson, a professor and head of the Department of Public and Community Health at Utah Valley University. It is more of an annoyance to their lives.

Utahns ages 15 to 44 who have been sickened have a hospitalization rate of about 3% and a fatality rate below 1%. Still, they can spread the virus to older people at higher risk of complications or death.

The teens, 20- and 30-somethings dont seem to appreciate how contagious they can be, Jackson said. She noted that age group includes many of the parents who have complained about masks being required in public schools.

Jackson, whose own children attend the Alpine School District, where angry adults on all sides of the masks-in-schools debate addressed the school board last week, said Friday she is feeling defeated about Utahs ability to contain the coronavirus.

I dont know how you fix this, Jackson said. I dont know how you get people to take this seriously.

In Salt Lake County, residents who are ages 20 to 29 represent the biggest segment of new coronavirus cases on a per 100,000 population basis, said Michelle Vowles, an epidemiologist with the county health department.

While that group often is seen as synonymous with nightlife, Vowles said there are no reports of anyone in Salt Lake County contracting COVID-19 in, say, a bar.

So it may not be a case of the young and the reckless. Instead, Vowles said, information from contact tracing shows these adults may be getting the virus at food, retail, warehouse and construction jobs where social distancing may be more difficult.

That age group, Vowles said, tends to be our workers.

When the pandemic struck, the average infected Salt Lake County resident was 43 years old, Vowles said. Now, he or she is 36.

The solution for the younger adults, she added, is the same as it is for everyone wash your hands, physically distance and, when you cant ensure that space, wear a mask.

New data shows how effective Salt Lake Countys recent mask mandate has been in reducing the spread of the virus, but Vowles said early reports indicate that more people are, at least, wearing face coverings.

A lot of times, she said, its hard to change behavior just by knowledge alone.

Jackson said a public service blitz targeted at people ages 15 to 44 might prove effective. Utah has already had campaigns to reduce suicide and alcohol use among young people.

Any COVID-19 push, Jackson said, cant just tell young people how many the virus has killed, but should tell personal stories of those who have died.

Thats so much more impactful, she said, than just sheer numbers.

Zander Moodys grandparents Carol and John Moody contracted COVID-19 in early May. Carol Moody died May 21 at age 71. John Moody is recovering.

The virus spread to Zanders parents and uncles over May, but not to the teenager or his sister. Zander began to feel a fever and sore throat July 8.

When his mother, Hilary Moody, took him to Alta View Hospital for testing, she said she started crying and had a panic attack in the parking lot. Its the same place she took her in-laws for testing when they were sick.

It just kind of brought it all back, she said.

After Zander tested positive, the family members did what they did in May. The patient Zander stayed in his room. His mother brought him food. She, Zanders father and sister are all in quarantine to ensure they cant infect others.

Hilary said the Salt Lake County Health Department warned her that she and her husband could contract COVID-19 again. Her 13-year-old daughter has not had the virus yet and fears contracting it after what happened to her grandmother and seeing others in her family so sick.

Before he fell ill, Zander was spending time only with a few friends, his mother said, but she believes that created a false sense of security.

You dont factor in that those kids are going to football or another school where they could get it, the mom said.

Zander said fatigue is his only remaining symptom. Not spending time with friends has been the hardest part of the pandemic for kids like him.

Were teenagers, he said. Its kind of what we do.

Tribune reporter Erin Alberty contributed to this story.

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Millennials, teens are Utah's biggest sources of COVID-19 infections, and the state hasn't been able to stop that - Salt Lake Tribune

S.D. County Reports More Than 600 COVID-19 Cases For Second Time – KPBS

Photo by Alexander Nguyen

Above: A playground in San Diego County closed to reduce the spread of coronavirus in this undated photo.

The number of daily COVID-19 cases in San Diego County has crossed 600 for the second time as the number of total cases rose to 23,114.

County public health officials reported 625 new cases Saturday and six additional deaths, raising the death count to 478.

Of the six deaths, four were women and two were men. They died between July 8 and 16 and ranged in age from 60 to mid-90s. All had underlying health conditions.

The county recorded 10,290 tests Saturday, 6% of which returned positive. Saturday's test numbers were the second-highest numbers reported, trailing only Friday's figures. The 14-day rolling average is now 6%. The state's target is below 8% positive test rate.

One new community outbreak was identified, in a healthcare setting on July 10. In the past seven days, 17 community outbreaks were identified. The number of community outbreaks remains more than double the trigger of seven or more in seven days.

A community outbreak is defined as three or more COVID-19 cases in a setting and in people of different households.

Of the total positive cases, 2,180 or 9.4% have been hospitalized and 567 or 2.5% of cases have been admitted to an intensive care unit.

A new record of 153.2 of every 100,000 San Diegans are testing positive for the illness as of Thursday's data, well above the state's criterion of 100 per 100,000.

San Diego County COVID-19 data from July 18, 2020

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The last metric the county has failed to maintain is the percentage of cases that have been handled by a contact investigator within 24 hours of it being reported. There are more than 500 investigators employed by the county, and although 98% of all cases had been investigated in that time frame as recently as June 25, that rate has dropped to a dismal 37%. The county metric is to reach 71% of new cases in a day's span.

Dr. Wilma Wooten, San Diego County's public health officer, said in response to these flagging rates, the county is attempting to hire more contact investigators. In just a three-hour period after the job posting went online Wednesday, more than 300 applications came in.

To help the South Bay increase testing capability, the county Health and Human Services Agency and County Board of Supervisors Chairman Greg Cox opened a new testing site in Imperial Beach Thursday morning.

The free, drive-up testing site is in the parking lot of Mar Vista High School, at 505 Elm Ave. The site will offer up to 185 appointments per day.

This new location brings the total number to six testing sites in South County and is part of the County's South Bay Saturation strategy. Additional testing sites are located in San Ysidro, two in Chula Vista and two in National City.

The number of cases continues to rise in people between the ages of 20 and 49 and particularly in people in their 20s, prompting the county to make efforts at educating younger people.

San Diego residents between 20 and 29 years old account for 25% of the county's cases, the highest percentage of any age group, according to county data.

"While it's true that the mortality for younger people is lower, it's also true that the rate is not zero," said Dr. Scott Eisman, pulmonologist at Scripps Memorial Hospital Encinitas. "The complications from this illness are far greater, much longer lasting and far more serious than the flu."

Eisman said in studies of the outbreaks of SARS and MERS other coronaviruses people who had the disease and showed symptoms sometimes didn't regain original lung capacity until a year or longer after the symptoms began.

"All indications lead us to expect it to be at least as serious as those diseases and much more aggressive," he said, adding that even otherwise healthy people could see months of complications from the illness.

Eisman also said heart attacks, strokes and serious blood clots were increasing among younger people confirmed to have COVID-19. A total of 58% of those confirmed to have the disease in the county were between the ages of 20 and 49.

Following Gov. Gavin Newsom's updated health order Monday, all indoor operations ceased at midnight Tuesday in gyms, houses of worship, non-critical office businesses, hair salons and barber shops, indoor malls and personal care services, such as massage businesses and tattoo parlors.

The Del Mar Thoroughbred Club canceled its racing program for Saturday and Sunday after 15 jockeys recently tested positive for COVID-19. Racing is slated to resume July 24.

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S.D. County Reports More Than 600 COVID-19 Cases For Second Time - KPBS

Almost 500 people have died of COVID-19 in Orange County – Los Angeles Times

Orange County reported 25 more deaths connected to the novel coronavirus on Saturday, the third-highest day on record as the number of confirmed cases continues to surge.

Health officials said that 109 deaths have been reported in the last two weeks, and 494 since the pandemic began. The deaths reported Saturday included seven people who lived in institutional settings such as nursing homes.

The number of confirmed COVID-19 cases countywide climbed to 29,011, with 702 new cases reported Saturday. The number of infections in Orange County has grown dramatically over the last month, and is now second only to Los Angeles County.

Across California, transmission rates for coronavirus continued to rise. The total number of confirmed COVID-19 cases topped 375,000 Friday, and the number of deaths exceeded 7,600.

Gov. Gavin Newsom added Orange County to his coronavirus watchlist because the share of COVID-19 tests that have come back positive, and the number of people infected per 100,000 residents, are too high to meet state benchmarks.

Over a seven-day period, 13.9% of COVID-19 tests came back positive. Over the last two weeks, officials have confirmed 12,531 new cases, an average of 396 positive tests per 100,000 Orange County residents a rate equivalent to that of L.A. County.

Orange and Riverside counties have seen the number of hospitalized patients with confirmed COVID-19 infections nearly triple in the last two months. In San Bernardino County, that number has more than quadrupled. All three counties allowed many businesses to reopen a week before Los Angeles County.

California has mandated face coverings in public settings since June 18. But Orange County has become a hotbed of opposition to that rule, sparking concern from public health officials who say the coverings are among the most effective tools to slow the spread of the virus.

Orange Countys former health officer resigned after receiving weeks of verbal abuse, including a death threat, over her mandatory mask order.

Last week, education officials approved recommendations that would allow public schools to reopen in the fall without requiring social distancing or mandatory mask policies, prompting immediate backlash.

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Almost 500 people have died of COVID-19 in Orange County - Los Angeles Times

Employers are requiring COVID-19 testing that workers cannot get – Street Roots News

Many employers in Oregon are sending healthy workers in for COVID-19 testing when a coworker gets sick. Public health officials wish theyd stop.

Debbie Lamberger said its becoming a regular occurrence: Coworkers arrive in a group of cars at one of Oregon Health & Science Universitys mobile testing sites to request COVID-19 testing, all saying someone at their workplace recently tested positive. Now, their boss has directed them to the testing site.

Thats what these mobile testing sites are for, and OHSU has two: one at Portland Expo Center and one at Hillsboro Stadium.

But upon further discussion, Lamberger, who is OHSUs director of ambulatory operations, told Street Roots, shell discover the patients dont meet the criteria for testing.

Ill say, Have you been within 6 feet for more than 15 minutes? Lamberger said. As soon as I ask the question specifically, people wise up, and they know theres only one right answer if theyre going to get tested.

But, she said, patients tell her they cant return to work unless they can prove theyve tested negative for the virus.

They are often low-wage workers or people who are not covered under Oregons sick time law, Lamberger said. The law offers a week of paid sick time to employees at companies that employ 10 or more people and unpaid-but-protected sick time to workers at smaller businesses.

This means without a test to show theyre negative, they may temporarily lose their source income while they quarantine.

She gave an example of a group of workers at a small construction company she turned away because they didnt meet the criteria for testing.

It does result in hardship for all of these workers who dont have sick time when the lowest-barrier site in the state, which is us, we wont do it, Lamberger said.

Lamberger and Jessica Guernsey, Multnomah Countys deputy director of public health, agreed that in ideal circumstances, testing as many people as possible would be key to helping contain the virus.

Experts touted broadly available on-demand testing as a key component in keeping South Koreas case count low, for example. To date, the country has reported 12,460 recovered cases and just 293 deaths.

Do I agree that testing should keep everyone safe? Absolutely, Guernsey said. Is the reality on the ground consistent, given the lack of testing strategy?

Instead, public health officials are urging employers not to make testing a requirement for returning to the jobsite unless theres a known exposure at a worksite where individuals work in close proximity.

And, theyre prioritizing tests for individuals with symptoms, those with recent close exposures such as family members or coworkers who work side by side as well as individuals in high-risk groups.

We cant make employers not ask people (to get tested), Guernsey said. Were asking them to follow CDC requirements and not refer people for testing if they havent had symptoms or a recent exposure.

ZOOM+Cares chief medical officer, Erik Vanderlip, said his chain of urgent care clinics is also seeing patients who were sent in for testing at the request of their employer.

He said ZOOM+Care is actively working with employers to develop a COVID-19 detection program that will help keep their workplaces safe and productive.

But, its difficult to determine how many employers are making negative COVID-19 test results a condition of returning to work and what industries theyre in.

Employment status is not part of standard intake questions and not something Multnomah Countys health clinics are tracking, Guernsey said.

The states Bureau of Labor and Industries began tracking employment complaints related to COVID-19 at the beginning of April and released a list of 28 complaints to Street Roots.

The list didnt give specific details on the reports, but did categorize them by nature of complaint. Two, for example, were related to sick leave, five were related to disability, one to race, one to sex and one to whistleblowing.

More than half fell under the umbrella of the Oregon Occupational Health & Safety Administration.

According to Oregon OSHA spokesperson Aaron Corvin, the majority of COVID-19-related complaints his agency has received have, by and large, involved allegations of failures to follow COVID-19 restrictions including social distancing, mask wearing and other measures.

More testing is a good thing, Corvin said. Employers implementing robust testing protocols is in line with universal controls meant to address a public health crisis.

According to Lamberger, some large employers have reached out to OHSU about providing onsite testing at workplaces.

Heres the unfortunate catch-22: Weve had a number of employers reach out to us and say, Well pay if you test our employee, but we dont have the staff, Lamberger said.

Instead, OHSU has referred employers to private lab partners, and OHSU is trying to increase its staffing for tests despite reporting financial losses related to the pandemic.

According to Oregon Health Authority spokesperson Delia Hernndez, the state currently has the capacity to process 41,000 weekly tests. Last week OHSU processed about 3,200 tests.

During the week of July 6-12, less than 33,000 people in Oregon were tested for COVID-19 in Oregon. Thats 8,000 fewer than the state says it has the capacity to test.

As of Friday, 323,478 tests had been conducted statewide since the start of the pandemic.

Were doing a swab every 90 seconds, Lamberger said.

So far, local labs are reporting turnaround times for test results that fall within national guidelines.

We turn around test results within 48 to 72 hours from the point at which its collected at one of the mobile sites, OHSU spokesperson Erik Robertson told Street Roots.

Legacy has said it can get test results in two to three days.

But nationally, labs say theyre so overwhelmed with test results that theyre not getting results to patients for a week or more and that chips away at the usefulness of testing.

Multnomah County officialssay turnaround time for test results locally has varied since thepandemic began and it depends on which category a patient is in. The Department of Health and Human Services has defined three patient priority levels, with hospitalized patients and health care workers with symptoms being highest priority.

Right now, those patients are getting test results within 24 hours, Multnomah County spokesperson Kate Wilson said.

Patients in Multnomah County who fall into the second priority category those who arein long-termcare facilities with symptoms, patients older than 65 with symptoms, patients with underlying conditions with symptoms and first responders with symptoms are currentlygetting results within two days, Wilson said.

And finally,for patients in the third priority category those who are critical infrastructure workers with symptoms,individuals not in the other categories who have symptoms,health care facility workers,first respondersand individuals in communities experiencing high numbers of COVID-19 hospitalizations the turnaround time is 11 to 12 days.

Wison confirmed that the county does notkeep track of the number of people who ask for tests but are turned away.

If we start testing everyone, its going to take two weeks to get tests back and then theres no point in testing, Lamberger said.

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Employers are requiring COVID-19 testing that workers cannot get - Street Roots News

Another confirmed COVID-19 case in Curry County | Bandon News – Coos Bay World

CURRY COUNTY On the afternoon ofJuly 18, Curry County Public Health received notification from Curry General Hospital of two confirmed cases of COVID-19. Public Health reached out to one of the individuals and learned that the person has not been in close contact with anyone for an extended period of time other than his spouse, according to a press release from Curry County Public Health Administrator Sherri Ward.

Contact tracing has been initiated in this case and at this point the individual has been instructed to self-isolate and monitor his symptoms.

The second person who tested positive is from Southern California and has been visiting and staying with family in Crescent City, Calif. That individual was able to get tested at Curry Medical Center in Brookings. This individual will be referred back to California for further contact tracing.

"It is important that we all follow the OHA and CDC guidelines and Governors directives about social distancing, wearing facial coverings in public buildings and protecting yourselves by staying home to slow the spread and save lives," Ward wrote.

Curry County Public Health will continue to keep the public informed with all the COVID-19 information.

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Another confirmed COVID-19 case in Curry County | Bandon News - Coos Bay World

WHO Director-General pays tribute to Spain’s sacrifices and leadership to confront COVID-19 – World Health Organization

World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus today joined the leadership of Spain, paying homage to those who have lost their lives in the country due to COVID-19, saluting the heroic efforts of heath workers and praising the governments resolute and robust response to reverse the viruss transmission.

It is with great respect that I join the King of Spain, the Prime Minister and the entire government of the country to pay tribute to the people who have fallen victim to COVID-19, said Dr Tedros. I extend my deepest condolences to the families of all people who have lost their lives due to this virus in Spain, and around the world.

At one point, Spain was among the countries impacted most by COVID-19. At the outbreaks peak, close to 10,000 new cases were reported in a single day in Spain. Since then, intensive efforts, led by robust surveillance, testing, contact tracing, treatment and isolation, have managed to suppress transmission.

Dr Tedros said this shift was due to the leadership shown by Spain and the strong resolve shown by the Spanish public to adhere to strict restrictions, including lockdowns, physical distancing and other critical measures to contain transmission. These efforts, combined, have successfully changed the course of the countrys outbreak.

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WHO Director-General pays tribute to Spain's sacrifices and leadership to confront COVID-19 - World Health Organization

Public Health: 11000 children and teens have been infected with COVID-19 – Santa Clarita Valley Signal

The Los Angeles County Public Health Department reported Saturday that since the onset of the pandemic, 11,000 children and teens have been infected with COVID-19.

The Santa Clarita Valley saw 23 more cases be reported across both incorporated and unincorporated communities in the last day, bringing the total number of cases to 3,886.

Henry Mayo Newhall Hospital released its weekly tallies Wednesday, which showed that more than 150 tests have been conducted in the past 48 hours, totaling 4,482 since the start of the pandemic. Of those, 495 returned positive, an increase of 41 in the past 48 hours, and 4,201 negative, an increase in 191, while 458 remain pending, according to spokesman Patrick Moody. A total of 140 people have recovered and 23 remained at the hospital an increase of eight since Monday.

Additionally, in the last 24 hours, there have been 37 new deaths and 2,770 new cases reported countywide. This brings the cumulative total number of cases to 153,041 and the total number of deaths related to COVID-19 to 4,084.

For the families that are experiencing the profound grief of losing a loved one to COVID-19, we grieve with you and you are in my thoughts, said Barbara Ferrer, director of public health, in a statement issued Saturday. We continue to see concerning data, including data that shows us that younger people are contributing to the increased spread of COVID-19.

Currently, there are 21,888 confirmed cases that have had to be hospitalized, 28% of those people are in the iCU and 18% require ventilators. Data shows that the 18-40 year old age group continue to be hospitalized at the highest rate.

Throughout the country, .7% to 9.1% of all child COVID-19 cases resulted in hospitalization, according to the American Academy of Pediatrics.

Of those who died within the last day countywide, 25 people were over the age of 65 years old, nine people who died were between the ages of 41 and 65 years old and two people who died were between the ages 18 and 40. 31 people had underlying health conditions.

The mortality rate countywide is now at 2.66% among confirmed cases.

Santa Clarita Valley cases

The number of SCV cases, including all area health care providers daily figures and those at Pitchess Detention Center, totaled 3,886 on Saturday, broken down into region, are as follows:

City of Santa Clarita: 1,761

Unincorporated Acton: 37

Unincorporated Agua Dulce: 15

Unincorporated Bouquet Canyon: 1

Unincorporated Canyon Country: 62

Unincorporated Castaic: 1,834 (majority of Castaic cases come from Pitchess Detention Center, exact number unavailable)

Unincorporated Lake Hughes: 1

Unincorporated Newhall: 4

Unincorporated Placerita Canyon: 0

Unincorporated San Francisquito Canyon/Bouquet Canyon: 0

Unincorporated Sand Canyon: 2

Unincorporated Saugus: 11

Unincorporated Saugus/Canyon Country: 1

Unincorporated Stevenson Ranch: 91

Unincorporated Val Verde: 37

Unincorporated Valencia: 29

To view all coronavirus-related stories, visit signalscv.com/category/news/coronavirus.

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Public Health: 11000 children and teens have been infected with COVID-19 - Santa Clarita Valley Signal

Texas pastor dies of Covid-19 a month after giving sermon on the virus’ impact on her community – CNN

At her church, she spoke about racial tensions in our country and the deaths of Ahmaud Arbery and George Floyd. She also talked about Covid-19 testing shortages and remembered the more than 100,000 people who have died from the coronavirus in the US in the last four months.

A little more than a month later, on July 10, the progressive pastor died of pneumonia caused by the coronavirus. Rev. Gibbs was 57. Her death came five days after she had tested positive, her wife Cassandra White says.

After arriving at Resurrection Metropolitan Community Church, she helped establish the church's gospel ensemble and also formed an African American women's ensemble. Rev. Gibbs worked in various other roles at the church over the last 40 years, including as a member of the church's Board of Directors and as a confidential administrative assistant for its senior pastor.

Rev. Gibbs was ordained in December 2014, and continued to serve as the church's curriculum specialist and Diversity and Inclusion Program coordinator. She then transitioned to her current role as associate pastor in 2015.

Rev. Gibbs married White, the gospel ensemble director at the church, in 2016. According to her wife, Vickey was diagnosed with lupus at a young age and had exceeded her life expectancy.

In an interview with CNN, White said she'll miss her passion for social justice as well as her ability to whip up colorful, beautiful breakfasts for them to eat together.

Rev. Gibbs's passion for social justice extended outside of the church as well, her wife says. White said that Vickey would try to call out racism in daily life and participated in countless marches and events in Houston, even though she knew that she would get sick because of her lupus.

White says that after her passing, she found a list that she had left for her. On top of that list was an apology from Vickey exclaiming her sadness that they did not have more time together. The next item on the list was a reminder to White to tell their grandson, whom Vickey had nicknamed "Boo," every day that she loves him.

White says from early in their relationship she realized that she had to share Vickey with the world, because she had a calling and was destined for greatness.

Rev. Gibbs is also survived by two daughters, Cara and Ariel, and a grandson who she doted on constantly.

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Texas pastor dies of Covid-19 a month after giving sermon on the virus' impact on her community - CNN

Covid-19 impact on ethnic minorities linked to housing and air pollution – The Guardian

The severe impact of Covid-19 on people from minority ethnic groups has been linked to air pollution and overcrowded and poor-standard homes by a study of 400 hospital patients.

It found patients from ethnic minorities were twice as likely as white patients to live in areas of environmental and housing deprivation, and that people from these areas were twice as likely to arrive at hospital with more severe coronavirus symptoms and to be admitted to intensive care units (ITU).

Minority ethnic groups were known to be disproportionately affected by Covid-19: they account for 34% of critically ill Covid-19 patients in the UK despite constituting 14% of the population. But the reasons for the disparity remain unclear.

The research is the first to examine the role of environmental and housing deprivation. Doctors praised the study but cautioned it has yet to be formally reviewed by other scientists and that additional, detailed studies in other areas are urgently needed.

The study also found patients from ethnic minorities were on average 10 years younger than the white patients, though the explanation for this is unknown. Age, frailty and underlying health conditions remain critical factors for all patients in determining the outcome of Covid-19.

The study concluded: Patients of black, Asian and minority ethnicity (BAME) are more likely to be admitted from regions of highest air pollution, housing quality and household overcrowding deprivation. This is likely to contribute an explanation towards the higher ITU admissions reported among Covid-19 BAME patients.

David Thickett, professor of respiratory medicine at the University of Birmingham and one of the study team, said. Its no surprise that people living in poor areas and poor housing do badly in a pandemic. Its been true since the Black Death and this reaffirms the importance of deprivation in influencing the pattern of disease.

A Public Health England report released in June showed a link between overall deprivation and worse coronavirus outcomes, but did not examine specific types of deprivation. At the time, the equalities minister, Kemi Badenoch, rejected claims that systemic injustice was the reason for the disparities. There is also compelling evidence of an association between dirty air and coronavirus infections and deaths.

Thickett said the public health message of the new study was better targeting of social distancing and handwashing advice to people in deprived areas and particularly those living in large households. I dont think there was very good engagement with ethnically diverse populations, particularly in terms of language barriers, he said.

The limitation of this study is that its in a single centre. Thickett said. What you really want is data from several different areas. This research is being planned.

Prof Stephen Holgate, the Royal College of Physicians special adviser on air quality, said: This seems a strong study with appropriate methods used. It suggests air pollution may be an important driver, he said.

Dr Aarash Saleh, an NHS respiratory doctor and member of the Doctors Against Diesel campaign said: We need more research like this to understand how air pollution interacts with other societal injustices to exacerbate health inequities, including death from Covid-19. Strategic responses to air pollution are urgently needed and must acknowledge and address the socioeconomic and racial intersections of this public health crisis.

The study, which has been submitted to a medical journal and made available online, followed 400 Covid-19 patients admitted to the Queen Elizabeth hospital in Birmingham. Two-thirds of the patients listed their ethnicity as white, 21% as Asian/Asian British and 7% were Black/African/Caribbean.

The analysis used deprivation data from the English Indices of Deprivation 2019 report published by the government. This divides the country into 33,000 small areas, containing an average of 650 households. Among the seven measures of deprivation are living environment, which comprises air pollution, housing in poor condition and road traffic accidents.

Another measure is barriers to housing and services, including household overcrowding, distance to amenities such as schools and GPs, and housing affordability. The researchers found a strongly suggestive statistical link between those living in the bottom 20% of areas under these measures, being from an ethnic minority and Covid-19 outcomes, said Thickett.

Air pollution and household overcrowding were already known to be associated with higher rates of community-acquired pneumonia and the worst air pollution levels are in neighbourhoods with a high population of minority ethnic residents. Thickett said the research was unlikely to explain why a disproportionate number of NHS staff from ethnic minorities had died from Covid-19: That cant just be due to deprivation, because they are at least in employment.

Prof Chris Griffiths, at Barts and the London School of Medicine, said: This study suggests that markers of socio-economic and environment are linked to pneumonia and ITU admission with Covid-19. This is important, but the [deprivation] measures used are really too broad to be able to point the finger at a specific component of each of these markers. More work is urgently needed.

Teasing out the individual components is difficult, said Prof Jonathan Grigg, of Queen Mary, University of London. He said the study was in line with his research showing exposure to air pollution increases the number of the ACE2 receptors that the coronavirus hijacks to enter the body.

Dr Gilles de Wildt, a Birmingham GP, said: Though the study is not yet peer reviewed, this is such an important area of research. We have all felt the clean air in Birmingham during the lockdown and know that emissions need to be curbed drastically for all healths sake, not just Covid-19.

Thickett said: For most diseases, theres a relationship with deprivation, frailty, [underlying illnesses] and age its not rocket science. What youre looking for is things that you can modify, to make things better for the future.

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Covid-19 impact on ethnic minorities linked to housing and air pollution - The Guardian

The Community That Covid-19 Built – The New York Times

The wagon on Jennifer Oiss front porch is a symbol of the coronaviruss silver lining. Its red and wooden, with black rubber wheels that once fell off, when Ms. Ois was towing her first child and a frozen turkey home from a store many years ago.

These days, the wagon is crowded with homemade things like fermented turmeric soda, ginger-berry kefir water, lemongrass ice cream and fresh lettuce from the garden, all waiting to be picked up by a neighbor.

Now its got a whole other purpose, says Ms. Ois. Its carrying kindness down her street.

Since visiting her neighborhood on Hiawatha Road a few weeks ago, Ive returned to it many times in my mind. I find it comforting. It reminds me that despite the viruss darkness, it has offered some illumination a slowing of time and a return to lifes essentials. The people on this street have used that time to learn old-fashioned skills like fermentation and growing vegetables, and in the process theyve become a community.

Theyve been lucky, too while some on the street have lost employment to the virus, this part of the city has been relatively unscathed by Covid-19 infections and deaths.

The street is classic east-end Toronto three long blocks of houses huddled together, as if for warmth. It was once part of a 600-acre farm owned by the Ashbridges, an English Quaker family from Pennsylvania who fled to Canada as Loyalists after the American Revolution. It remained a farm outside the city limits for more than a century, until the land was parceled and sold off for shacks for the immigrating poor and for planned subdivisions.

Walking down the street, you can see the signs of that history in the architecture old working-class bungalows wedged beside gentrified two-story brick homes. You can also see locals homesteading in ways that Sarah Ashbridge, the matriarch of the Quaker settlers, would likely recognize.

Ms. Ois is known locally as the fer-mentor. On her stove, a pot of water, grated ginger and molasses cools next to her ginger bug the makings for ginger ale. Her slow cooker is warming milk for yogurt. She pulls colorful jars out of her fermenting cupboard homemade vinegars, kombuchas and pickles.

For many years, she bugged her neighbors to try her hobby, but they were too busy, rushing from work to childrens hockey practices. When the country went into lockdown in March, she found a captive audience with long days to fill and anxiety to expend.

When this all happened, everyone else came into my world, said Ms. Ois, 43, a stay-at-home parent. Many said, I dont know what to do. Well, I know what to do. Im an expert at it.

She offered kombucha scobies, sourdough starter, and seeds for her neighbors nascent vegetable patches. She left them all in the wagon on her front porch, and texted pictures of her handwritten recipes.

Just down the street, Guillermo del Aguila had set up a hydroponics nursery in his basement for the first time, to supply the seedlings for his familys backyard greenhouse. He was better at it than he expected. He joined in the exchange, issuing his own community offerings: eggplant, sweet pepper, tomato and leek seedlings.

Jon Harris lives a few doors down. Both he and his wife had been deemed essential workers, so time had not stopped still for them. But he found making bread soothing. The baking section of grocery store shelves was bare, but he knew of a commercial mill and put out a call to the street. His first order was for 300 kilograms of flour and 25 pounds of yeast.

Theres something magical happening, said Mr. Harris, 44, an electrician.

He added, I wonder if there is something about watching the world spin around you and thinking about your mortality. We have a little more space to grab onto the things we want to be important.

The trading and pioneer hobbies have continued, even as the city has begun slowly to open up. Ms. Ois set up a swap page on Facebook, and offers went up from neighbors for homemade granola, freezer strawberry jam, lavender, eggs, espresso syrup, bitters for cocktails. Deborah MacDonald ventured to the red wagon to pick up champagne yeast to make raspberry mead, with Ms. Oiss handwritten recipe. She left fresh-baked bread.

I used to joke I didnt know anybody on the street, said Ms. MacDonald, a film producer who often clocked 11-hour days at the office. While there was a sense of community before, many of her neighbors barely knew each other before the virus stitched their friendships.

Weve all helped each other get through this crazy time, said Ms. MacDonald. In some respects its allowed us to forget a little about all the terrible.

Ms. Oiss husband hammered together a greenhouse in their backyard that she called the house Covid built. She and the del Aguila family plan to grow seedlings for their neighbors bursting gardens next spring.

Theres no going back, said Kara del Aguila, Guillermos wife, who considers the street her precious lifeline.

We dont order flowers for delivery anymore, she said. We go to our neighbors homes and knock on the front door and give them something we made.

Prime Minister Justin Trudeau apologized again this week this time for taking part in a decision to award a no-bid government contract to a charity deeply connected to his family. The countrys ethics commissioner is digging into the affair, marking the third time Mr. Trudeau has been investigated for breaking conflict-of-interest rules since coming to power in 2015.

Since a New Jersey hedge fund quietly assumed ownership of Postmedia, Canadas largest newspaper chain, the company has cut its work force, shuttered papers across Canada, reduced salaries and benefits, and centralized editorial operations in a way that has made parts of its 106 newspapers into clones of one another, my colleague Edmund Lee reports.

Catherine Porter is the Canada bureau chief, based in Toronto. Before she joined the Times in 2017, she was a columnist and feature writer for The Toronto Star, Canadas largest-circulation newspaper. Follow her on Twitter at @porterthereport

Were eager to have your thoughts about this newsletter and events in Canada in general. Please send them to nytcanada@nytimes.com.

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The Community That Covid-19 Built - The New York Times

Cell Therapy Processing Market Size, Share Growth, Trends, Devices, Applications, Competitive Analysis, Industry Expansion Strategies, By 2027 -…

The global Cell Therapy Processing market report provides geographic analysis covering regions, such as North America, Europe, Asia-Pacific, and Rest of the World. The Cell Therapy Processing market for each region is further segmented for major countries including the U.S., Canada, Germany, the U.K., France, Italy, China, India, Japan, Brazil, South Africa, and others.

FYI, You will get latest updated report as per the COVID-19 Impact on this industry. Our updated reports will now feature detailed analysis that will help you make critical decisions.

Browse Full Report: https://www.marketresearchengine.com/cell-therapy-processing-market

Cell therapy is the therapeutic application of cells despite cell kind or clinical indication a platform technology. Regenerative drugs is an approach to treating patients and so definitely not a platform technology. Its nearest to a hospital specialty, for example, medicine, medical specialty or palliative drugs, in alternative words platform technology independent. Its goals are ultimately to cure and so a paradigm shift away from typical symptom management and pain management. While its true that some cell therapies are regenerative, the bulk are not. Even as regenerative drugs is much larger than regenerative cell therapies alone, cell therapies collectively represent a market opportunity several orders of magnitude bigger than regenerative drugs. Equating one with the other is therefore not advantageous however instead will each a major disservice.

The global Cell Therapy Processing market is expected to exceed more than US$ 11.5 Billion by 2024, at a CAGR of 16.2% in the given forecast period.

Market Insights

The global Cell Therapy Processing market is segregated on the basis of Process as Cell Processing, Cell Preservation, Distribution, and Handling, and Process Monitoring and Quality Control. Based on Product Type the global Cell Therapy Processing market is segmented in Equipment, 1 Cell Processing Equipment, 2 Single-Use Equipment, 3 Other Equipment, Systems & Software, and Consumables. Based on End User the global Cell Therapy Processing market is segmented in Life Science Research Companies and Research Institutes.

Based on Cell Type, the global Cell Therapy Processing market is segmented in Human Cells, 1 Stem Cells, 2 Differentiated Cells, and Animal Cells.

Competitive Rivalry

Stemcell Technologies, Miltenyi Biotec GmbH, Beckman Coulter, Inc, Becton, Dickinson and Company, Ge Healthcare, Sartorius, Merck KGaA, Lonza Group, Thermo Fisher Scientific, Inc., Terumo Bct, Inc, and others are among the major players in the global Cell Therapy Processing market. The companies are involved in several growth and expansion strategies to gain a competitive advantage. Industry participants also follow value chain integration with business operations in multiple stages of the value chain.

The Cell Therapy Processing Market has been segmented as below:

The Cell Therapy Processing Market is segmented on the lines of Cell Therapy Processing Market, By Process, Cell Therapy Processing Market, By Product Type, Cell Therapy Processing Market, By End User, Cell Therapy Processing Market, By Cell Type, Cell Therapy Processing Market, By Region and Cell Therapy Processing Market, By Company.

Cell Therapy Processing Market, By Process this market is segmented on the basis of Cell Processing, Cell Preservation, Distribution, and Handling and Process Monitoring and Quality Control. Cell Therapy Processing Market, By Product Type this market is segmented on the basis of Equipment its covers 1 Cell Processing Equipment, 2 Single-Use Equipment & 3 Other Equipment. Systems & Software and Consumables. Cell Therapy Processing Market, By End User this market is segmented on the basis of Life Science Research Companies and Research Institutes. Cell Therapy Processing Market, By Cell Type this market is segmented on the basis of Human Cells its covers 1 Stem Cells & 2 Differentiated Cells. And Animal Cells. Cell Therapy Processing Market, By Region this market is segmented on the basis of North America, Europe, Asia-Pacific and Rest of the World. Cell Therapy Processing Market, By Company this market is segmented on the basis of Stemcell Technologies, Miltenyi Biotec GmbH, Beckman Coulter, Inc, Becton, Dickinson and Company, Ge Healthcare, Sartorius, Merck KGaA, Lonza Group, Thermo Fisher Scientific, Inc. and Terumo Bct, Inc.

The report covers:

Report Scope:

The global Cell Therapy Processing market report scope includes detailed study covering underlying factors influencing the industry trends.

The report covers analysis on regional and country level market dynamics. The scope also covers competitive overview providing company market shares along with company profiles for major revenue contributing companies.

The report scope includes detailed competitive outlook covering market shares and profiles key participants in the global Cell Therapy Processing market share. Major industry players with significant revenue share include Stemcell Technologies, Miltenyi Biotec GmbH , Beckman Coulter, Inc, Becton, Dickinson and Company, Ge Healthcare, Sartorius , Merck KGaA, , Lonza Group , Thermo Fisher Scientific, Inc., Terumo Bct, Inc, and others.

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Table of Contents:

5. Cell Therapy Processing Market, By Process

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Longevity And Anti-Senescence Therapy Market Value Chain and Forecast COVID-19 2023 – Kentucky Journal 24

The global longevity and anti-senescence therapies market should grow from $329.8 million in 2018 to $644.4 million by 2023 with a compound annual growth rate (CAGR) of 14.3% during 2018-2023.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

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Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023 Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

Summary

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography. Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

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Longevity And Anti-Senescence Therapy Market Value Chain and Forecast COVID-19 2023 - Kentucky Journal 24

Duvelisib May Reduce Lung Inflammation in Patients With COVID-19 – Targeted Oncology

Duvelisib (Copiktra), an anticancer drug, is currently being explored as treatment to reduce lung inflammation in hospitalized patients with coronavirus disease 2019 (COVID-19) in an investigator-initiated phase 2 study at the Winship Cancer Institute of Emory University.

The rationale behind the use of duvelisib is that the drug may be able to calm the systemic inflammation that exacerbates COVID-19-associated pneumonia and acute respiratory distress syndrome, stated principal investigator Edmund K. Waller, MD, PhD, professor, Hematology and Medical Oncology, Medicine and Pathology, Emory University School of Medicine, holder of Rein Saral, MD Professorship in Cancer Medicine, and medical director, Center for Stem Cell Processing and Apheresis, Emory University Hospital.

Pre-clinical data suggests that the agent can mitigate T cell exhaustion. More research has demonstrated T cell exhaustion limits the effectiveness of the immune system in fighting the infection.

Wallers lab has also previously tested whether duvelisib can enhance the activity of chimeric antigen receptor T-cell therapy in patients with cancer prior to the onset of the COVID-19 pandemic.

The phase 2 study will enroll 40 patients who are hospitalized with COVID-19-associated pneumonia. The trial is expected to last for 1 year. Every patient will receive either duvelisib or placebo for 2 weeks. Efficacy will be determined after 1 month. Patients will receive standard-of-care treatment and may receive antiviral medications, such as remdesivir (Veklury).

Waller is joined by co-investigators Aneesh K. Mehta, MD, and Marshall Lyon III, MD, infectious disease specialists, Emory Winship.

"This study is an example of how research on cancer immunology can be repurposed and deployed against COVID-19, possibly improving patient outcomes during this crisis," said Walter J. Curran, Jr, MD, the Lawrence W. Davis Chair, Radiation Oncology, Georgia Research Alliance Eminent Scholar, Chair in Cancer Research, and executive director, Winship, in a statement. "We are happy to be able to cooperate with our infectious disease and critical care colleagues in this effort."

The FDA previously granted approval to duvelisib in September 2018 for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Duvelisib can reduce levels of some of the same immune messenger cytokines that become elevated during a COVID-19 infection, according to previous data from patients with leukemia and lymphoma. In the phase 3 DUO trial (NCT02004522), the study in which the approval was based on, duvelisib reduced the risk of disease progression or death by 60% compared with ofatumumab (Arzerra) in patients with relapsed/refractory CLL/SLL who had received at least 2 prior lines of therapy.

Reference

Repurposing a cancer drug to reduce COVID-19 lung inflammation. News Release. July 13, 2020. Accessed July 16, 2020. https://bit.ly/2WpWrr2

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Duvelisib May Reduce Lung Inflammation in Patients With COVID-19 - Targeted Oncology

Humanigen Expands Partnership with Catalent Biologics to Manufacture Investigational COVID-19 Therapeutic Candidate Lenzilumab – Business Wire

SOMERSET, N.J. & BURLINGAME, Calif.--(BUSINESS WIRE)--Catalent and Humanigen, Inc. (HGEN) (Humanigen) today announced the expansion of their relationship, under which Catalent will provide development, manufacturing and commercialization services for lenzilumab, Humanigens proprietary Humaneered anti-human granulocyte macrophage-colony stimulating factor (GM-CSF) monoclonal antibody.

Catalent is the leading global provider of advanced delivery technologies, development, manufacturing and clinical supply solutions for drugs, biologics, cell and gene therapies and consumer health products. Humanigen is a clinical stage biopharmaceutical company focused on preventing and treating cytokine storm with lenzilumab, the companys lead therapeutic candidate.

Mayo Clinic recently announced data on the first clinical use of lenzilumab in 12 patients with severe and critical COVID-19 pneumonia, the majority of whom showed rapid recovery and hospital discharge. A Phase 3 study is currently underway evaluating hospitalized COVID-19 patients.

Based on lenzilumabs promising clinical data, we are pleased to expand our relationship with Catalent to solidify our ability to manufacture and supply lenzilumab, commented Cameron Durrant, MD, MBA, Chief Executive Officer of Humanigen. If we are able to secure FDA approvals or Emergency Use Authorization, Catalent Biologics deep expertise and integrated OneBio solution will accelerate our ability to get this therapy to patients that need it most.

Catalent has partnered closely with Humanigen to develop and supply lenzilumab for clinical trials, commented Karen Flynn, President of Catalent Biologics and Chief Commercial Officer. The experience we already have with lenzilumab, and our OneBio integrated offering from development to supply, make Catalent uniquely suited to support Humanigen in the journey to make this promising therapy available to COVID-19 patients as soon as possible following receipt of regulatory approvals.

To date, Catalent Biologics has provided early-stage development and clinical cGMP drug substance manufacturing for lenzilumab at its facility in Madison, Wisconsin to support Humanigens ongoing clinical trials across various disease categories. Under the expanded partnership, Catalent is also providing clinical supply support for Humanigens Phase 3 potential registration study in COVID-19 from its Philadelphia facility.

Lenzilumab was originally manufactured in Catalents Madison facility using Catalent Biologics proprietary GPEx cell line development technology. As part of the expanded partnership, Catalent intends to provide additional drug substance clinical supply for Humanigens clinical trials, Expanded Access Program (EAP), as well as additional late-stage development and clinical and potential commercial drug substance manufacturing and vial filling at its Madison and Bloomington, Indiana, sites.

Catalent Biologics Madison facility provides development and drug substance manufacturing, including GPEx cell line development, process development, process validation, formulation development, and clinical and commercial cGMP manufacturing. Its Bloomington facility has deep expertise in sterile formulation, with drug substance development and manufacturing and drug product fill/finish capacity across liquid and lyophilized vials, prefilled syringes, and cartridges as well as primary and secondary packaging.

Catalents OneBio Suite is an integrated solution for the development, manufacturing, and supply of biologic drugs. Launched in May 2019, the suite of offerings is designed to integrate activities and accelerate timelines, reduce risk and simplify development with a single contract, program manager, and development timeline from cell line development to supply, with harmonized quality systems.

About Humanigen, Inc.

Humanigen, Inc. is developing its portfolio of clinical and pre-clinical therapies for the treatment of cancers and infectious diseases via its novel, cutting-edge GM-CSF neutralization and gene-knockout platforms. We believe that our GM-CSF neutralization and gene-editing platform technologies have the potential to reduce the inflammatory cascade associated with coronavirus infection. The companys immediate focus is to prevent or minimize the cytokine release syndrome that precedes severe lung dysfunction and ARDS in serious cases of SARS-CoV-2 infection. The company is also focused on creating next-generation combinatory gene-edited CAR-T therapies using strategies to improve efficacy while employing GM-CSF gene knockout technologies to control toxicity. In addition, the company is developing its own portfolio of proprietary first-in-class EphA3-CAR-T for various solid cancers and EMR1-CAR-T for various eosinophilic disorders. The company is also exploring the effectiveness of its GM-CSF neutralization technologies (either through the use of lenzilumab as a neutralizing antibody or through GM-CSF gene knockout) in combination with other CAR-T, bispecific or natural killer (NK) T cell engaging immunotherapy treatments to break the efficacy/toxicity linkage, including to prevent and/or treat graft-versus-host disease (GvHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, Humanigen and Kite, a Gilead Company, are evaluating lenzilumab in combination with Yescarta (axicabtagene ciloleucel) in patients with relapsed or refractory large B-cell lymphoma in a clinical collaboration. For more information, visit http://www.humanigen.com.

About Catalent Biologics

Catalent Biologics is a global leader in development, manufacturing and analytical services for new biological entities, cell and gene therapies, biosimilars, sterile injectables, and antibody-drug conjugates. With over 20 years of proven expertise, Catalent Biologics has worked with 600+ mAbs and 80+ proteins, produced 13 biopharmaceutical drugs using GPEx cell line development technology, and manufactured 35+ commercially approved products. Catalent Cell & Gene Therapy, a unit of Catalent Biologics, is a full-service partner for adeno-associated virus (AAV) vectors and CAR-T immunotherapies, with deep experience in viral vector scale-up and production. Catalent recently acquired MaSTherCell, adding expertise in autologous and allogeneic cell therapy development and manufacturing. Catalent Cell & Gene Therapy has produced 100+ cGMP batches across 70+ clinical and commercial programs. For more information, visit biologics.catalent.com.

About Catalent

Catalent is the leading global provider of advanced delivery technologies, development, manufacturing, and clinical supply solutions for drugs, biologics, cell and gene therapies, and consumer health products. With over 85 years serving the industry, Catalent has proven expertise in bringing more customer products to market faster, enhancing product performance and ensuring reliable global clinical and commercial product supply. Catalent employs over 13,500 people, including over 2,400 scientists and technicians, at more than 40 facilities, and in fiscal year 2019 generated over $2.5 billion in annual revenue. Catalent is headquartered in Somerset, New Jersey. For more information, visit http://www.catalent.com.

More products. Better treatments. Reliably supplied.

Humanigens Forward-Looking Statements

This release contains forward-looking statements. Forward-looking statements reflect management's current knowledge, assumptions, judgment and expectations regarding future performance or events. Although management believes that the expectations reflected in such statements are reasonable, they give no assurance that such expectations will prove to be correct and you should be aware that actual events or results may differ materially from those contained in the forward-looking statements. Words such as "will," "expect," "intend," "plan," "potential," "possible," "goals," "accelerate," "continue," and similar expressions identify forward-looking statements, including, without limitation, statements regarding our expectations for the Phase III study and the potential future development of lenzilumab to minimize or reduce the severity of lung dysfunction associated with severe and critical COVID-19 infections or to be approved by FDA for such use or to help CAR-T reach its full potential or to deliver benefit in preventing GvHD. Forward-looking statements are subject to a number of risks and uncertainties including, but not limited to, the risks inherent in our lack of profitability and need for additional capital to conduct the Phase III study and grow our business; our dependence on partners to further the development of our product candidates; the uncertainties inherent in the development and launch of any new pharmaceutical product; the outcome of pending or future litigation; and the various risks and uncertainties described in the "Risk Factors" sections and elsewhere in the Company's periodic and other filings with the Securities and Exchange Commission.

All forward-looking statements are expressly qualified in their entirety by this cautionary notice. You should not place undue reliance on any forward-looking statements, which speak only as of the date of this release. We undertake no obligation to revise or update any forward-looking statements made in this press release to reflect events or circumstances after the date hereof or to reflect new information or the occurrence of unanticipated events, except as required by law.

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Humanigen Expands Partnership with Catalent Biologics to Manufacture Investigational COVID-19 Therapeutic Candidate Lenzilumab - Business Wire

All Lives Matter protesters clash with Black Lives Matter protesters in front of Trump Tower – TheGrio

New York City Mayor Bill de Blasio, his wife Chirlane McCray and Rev. Al Sharpton help paint a Black Lives Matter mural on Fifth Avenue directly in front of Trump Tower on July 9, 2020 in New York City. In a tweet, President Trump called the mural a symbol of hate and said that it would be denigrating this luxury Avenue. (Photo by David Dee Delgado/Getty Images)

The Black Lives Matter street mural in front of Trump Tower has created the perfect hotspot for anti-BLM protesters.

Earlier this month, with the help of Mayor Bill de Blasio, Black Lives Matter painted its slogan outside of President Trumps old home on Fifth Avenue, near Columbus Circle.

This Saturday, protesters promoting the All Lives Matter movement congregated at the newly installed street mural, The New York Post reported.

READ MORE: Mayor De Blasio to install Black Lives Matter mural in front of Trump Tower

There was a clash between the two opposing sides. Some of the anti-BLM protesters could be seen with Blue Lives Matter flags. One flag read thin blue line, which is a police term used to indicate that the police are the force that hold society together.

In some videos, one woman can be seen cursing at the Black Lives Matter protesters while directing exaggerated coughing and sneezing gestures toward them.

The Daily Mail alleges that some of the anti-BLM protesters could be members of the Proud Boys, a violent gang of white young men whose views aligns with the alt-right.

The organization is ahate group, according to the US Southern Poverty Law Center.

According to The New York Post, some anti-BLM protesters decided to kneel while wearing their All Lives Matter shirts and Make America Great Again caps.

The anti-BLM protesters also interrupted a mans live recording about George Floyd. The group taunted the vlogger, screaming fk you! and making rude gestures.

READ MORE:Trump angrily responds to Black Lives Matter mural to be painted in front of Trump Tower

The anti-BLM protesters chanted USA and commie scum to Black Lives Matter members who were already chanting.

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All Lives Matter protesters clash with Black Lives Matter protesters in front of Trump Tower - TheGrio

A day in the life of a 5-year-old boy in 1935 – messenger-inquirer

A day in the life of a 5-year-old boy in 1935.

And what a day it could be even for a youngster who had to share almost nothing with five siblings.

Like almost every day, this day started about 5 a.m. when he was up and ready to help a mother, a lone parent living on little more than hope.

But that didnt bother the little boy. When you survive life without, you dont know anything about life with.

Mom would be ready to start fixing breakfast after he started the fire in the potbelly stove, and what a meal it would be. Homemade biscuits with grease gravy was as good as it could get.

And his mom liked the way he prepared that meal day after day. His biscuits were broken up into small bites and stacked in a cone-shaped manner. He called it gravy on the treetop.

Then it was up from the kitchen table and out the back door for a day of activities a whole lot like the day before. It started with a walk out of the backyard and onto property occupied by the Illinois Central Railroad. It was his place, he thought, to see if the huge steam engine was ready for its daily trip to Horse Branch and a meeting with a northeast IC train.

The little boy was sort of a pet with the understanding trainmen. They knew he lost his dad at the age of 2 and his part of helping run that railroad yard was deemed very important.

When there was time, Mr. Norman (last name unknown), the yardmaster, would walk him around the engine in a pretense of making sure it was ready for the days run. And he would tell his friend that he thought it was OK.

That railroad yard and the kindness of its employees was a vital part of the youngsters welfare.

When aware of his need for coal, Mr. Adkins, the big strong man who nightly refilled the engines hopper, would intentionally drop several shovels full down between the coal car and hopper so it could later be gathered up by the boy and taken to his coal-heated house.

Also available, thanks to the trainmen, was the ice remaining in the engines cooler when the train returned to the yard every afternoon. It served to keep the familys icebox in working order.

And then there was Owensboro Milling Company, the forerunner of Owensboro Grain, a business that also helped Hamilton Avenue residents with their need for corncobs.

The 5-year-old took advantage of that generosity by keeping a good supply of the waste product that was used to help make starting fires in stoves and grates a lot easier.

But coal, corncobs and making sure the big engine was ready for its daily run did not fill the little boys day. There would be games of marbles, pitching washers, sweeping the all-dirt backyard and perhaps making a homemade kite.

There would be walks through the cornfield separating Hamilton Avenue and Daviess County High to watch the older boys playing baseball, and riding his skipmobile down a long sidewalk that stretched from the front of the school to U.S. 60.

And what was a skipmobile? It was a scooter made of 2-by-4s and discarded iron state wheels.

Last but certainly not least would be a relaxing and loved-filled evening with Mom in the front porch swing. She would ask about his day and listen with ultimate interest. And when necessary, she would thank him for the coal and corncobs.

That made a little boy proud on a day in 1935.

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A day in the life of a 5-year-old boy in 1935 - messenger-inquirer

When the Day’s Catch Includes Cocaine and Heroin – Hakai Magazine

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Drug traffickers have been busted using everything from drones to ambulances to run narcotics, but the most valuable cargoes move over maritime routes. Law enforcement has cracked down on smuggling aboard container ships and other large vessels, but drug trafficking by the worlds 4.6 million fishing boats has largely been overlooked, says Dyhia Belhabib, principal investigator of fisheries at Ecotrust Canada.

As a result, the role that fisheries-based drug smuggling plays in a global industry worth US $650-billion a year was largely unknown. Now, a new study led by Belhabib reveals that criminals are increasingly using fishing vessels to smuggle illicit drugs, mainly high-value narcotics such as cocaine and heroin. She estimates that over $100-billion in drugs are trafficked aboard fishing vessels each year.

Crime at sea is not a new phenomenon. The fisheries sector is rife with illegal practices, including human trafficking, slavery, money laundering, unauthorized transshipment between vessels, and illegal, unreported, and unregulated fishing. These activities have been in the spotlight much more than drug trafficking, says Belhabib, and drug traffickers take advantage of the same legal loopholes and trade routes. These illegal operations are frequently carried out by criminal networks and international syndicates, making them types of transnational organized crime.

Vast, unpatrolled oceans provide ideal cover for these illicit activities. Even with the advent of satellite surveillance, we dont have the capacity to monitor the ocean as effectively as wed like, says Teale Phelps Bondaroff, director of research at nonprofit OceansAsia and an expert in fisheries crime who was not involved in the study. The high seas are hotspots for organized crime, as are the waters of developing countries with low enforcement capacity, he says. Where governance is poor, crime will flourish.

To quantify the role of fishing vessels in drug trafficking, Belhabib and her colleagues compiled information on drug seizures from global databases, reports, and media sources. Since most drug shipments are not detected by authorities, the researchers used statistical analyses to estimate the total quantity and value of drugs trafficked between 2010 and 2017.

They found drug seizures aboard fishing vessels tripled in the seven-year period, with the majority occurring on artisanal boats. The drug shipments were small but still high in value, indicating that traffickers are shifting shipments from large vessels to artisanal boats to avoid detection, says Belhabib.

Its a clever strategy, says Phelps Bondaroff. Fishing vessels tend to blend in, he says, whereas cargo ships or other big vessels may draw attention from authorities. Smaller shipments also minimize product loss if a vessel is captured, he adds.

There are multiple reasons why fishers engage in illicit activities, but it basically boils down to reduced catch and lost income, says Ifesinachi Okafor-Yarwood, a maritime security researcher at Scotlands University of St Andrews who was not involved in the research. To prevent fishers from turning to drug trafficking by necessity, governments should consult fishers and implement policies that supplement their livelihoods, says Okafor-Yarwood.

Even well-intentioned conservation effortssuch as no-take marine protected areascan exacerbate this cycle of poverty, forcing fishers to find other ways to sustain themselves, Belhabib says. Future research should examine why fishers turn to trafficking, she says, because the participation of small-scale fishers in the illicit drug trade is a symptom of something much bigger.

The ongoing COVID-19 pandemic has had mixed effects on small-scale fisheries, but has likely not drawn new fishers into drug trafficking, says Belhabib. The diversion of resources to the health crisis, however, is certainly good news for existing smuggling operations, she adds.

For vulnerable artisanal fishers already struggling to make ends meet, a harsh enforcement crackdown will only make things worse, warns Belhabib. Poverty is a main driver, and criminalizing the poor will not solve the problem. It never has.

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When the Day's Catch Includes Cocaine and Heroin - Hakai Magazine

US Turns Screws on Maritime Industry to Cut Off Venezuela’s Oil – Voice of America

LONDON/WASHINGTON - Several companies that certify vessels are seaworthy and ship insurers have withdrawn services to tankers involved in the Venezuelan oil trade as the United States targets the maritime industry to tighten sanctions on the Latin American country.

U.S. sanctions have driven Venezuela's oil exports to their lowest levels in nearly 80 years, starving President Nicolas Maduro's socialist government of its main source of revenue and leaving authorities short of cash for essential imports such as food and medicine.

The sanctions are part of U.S. efforts to weaken Maduro's grip on power after Washington and other Western democracies accused him of rigging a 2018 reelection vote. Despite the country's economic collapse, Maduro has held on and frustrated the administration of U.S. President Donald Trump.

Maduro's government says the United States is trying to seize Venezuela's oil and calls the U.S. measures illegal persecution that heap suffering on the Venezuelan people.

Washington has homed in on the maritime industry in recent months in efforts to better enforce sanctions on the oil trade and isolate Caracas, Washington's special envoy on Venezuela Elliott Abrams told Reuters.

"What you will see is most shipowners and insurance and captains are simply going to turn away from Venezuela," Abrams told Reuters in an interview.

"It's just not worth the hassle or the risk for them."

The United States is pressuring shipping companies, insurers, certifiers and flag states that register vessels, he said.

Ship classification societies, which certify safety and environmental standards for vessels, are feeling the heat for the first time.

The United States is pressuring classifiers to establish whether vessels have violated sanctions regulations and to withdraw certification if so, as a way to tighten sanctions further, a U.S. official told Reuters, speaking on condition of anonymity.

Without certification, a vessel and its cargo become uninsured. Ship owners would also be in breach of commercial contracts which require certificates to be maintained. In addition, port authorities can refuse entry or detain a ship.

London-headquartered Lloyd's Register (LR), one of the world's leading ship classifiers, said it had withdrawn services from eight tankers that were involved in trade with Venezuela.

"In accordance with our program for complying with sanctions' laws, where we become aware of vessels operating in breach of relevant sanctions laws, LR classification has been withdrawn," a Lloyd's Register spokeswoman said.

Abrams said the pressure on the maritime industry was working.

"We have had a number of shippers that come to us and say, 'We just had our insurance company withdraw the insurance, and the ship is on the high seas and we've got to get to port. Could you give us a license for one week?'" Abrams said.

In June, the United States designated six shipping companies -- two of them based in Greece - and six tankers they owned for participating in proscribed Venezuelan trade.

Another leading ship classifier, Hamburg-headquartered DNV GL Maritime, said it had suspended services for three of those vessels in June.

The company resumed services when the United States removed those vessels from the list of sanctioned entities after the shipping companies that own and operate the vessels agreed to cease trade with Venezuela.

Chilling effect

The United States has threatened sanctions on any company involved in the oil trade with Venezuela, and that has had a chilling effect even on trade permitted under sanctions.

Some oil companies are refusing to charter vessels that have called at Venezuelan ports in the past year, even if the voyage was exempt from sanctions.

"The shipping sector has been at the receiving end of U.S. action on Venezuela and it has caused much uncertainty as no one knows who will be next," one shipping industry source said.

Insurers are also in a bind. They have been conservative in their interpretation of U.S. sanctions to avoid any potential violations, said Mike Salthouse, chairman of the sanctions sub-committee with the International Group association. The group represents companies that insure about 90% of the world's commercial shipping.

"If there is ambiguity as to what is lawful and what is unlawful it makes it almost impossible for an insurer to say whether someone has cover or not," he said.

Even after ships and companies are removed from the sanctions list, they may face difficulties, Salthouse said.

"The stigma associated with a designation may last some time," he said.

Oil majors, for example, may review relationships with companies that own or manage vessels that the United States had designated and then removed to avoid any possible problems with other vessels, he said.

'Real threat

Venezuela is on the list of high-risk areas set by officials from London's insurance market.

"If a vessel sails to Venezuela they have to notify the underwriter and it may be that the underwriter will not be able to cover them," said Neil Roberts, head of marine underwriting at Lloyd's Market Association, which represents the interests of all underwriting businesses in London's Lloyd's market.

The industry faces "the direct and real threat of having its trade stopped by a watchful U.S. administration because of an inadvertent infringement," he said.

"This risk alone is enough to fuel the multiplication of compliance checks."

Some of the biggest global flag registries including Panama and Liberia are also looking more closely at ships that were involved in Venezuela trading as they come under U.S. pressure to withdraw registration for ships violating sanctions.

Maritime lawyers in Panama said its registry is fining vessels that do not comply with the U.S. maritime guidance issued in May. The registry is mostly de-flagging vessels targeted by multilateral sanctions rather than unilateral U.S. sanctions, the lawyers said.

Officials at Liberia's registry did not respond to requests for comment.

U.S. Commerce Secretary Wilbur Ross, a former investor in shipping, helped craft the strategy targeting the maritime sector, sources said.

A Commerce Department spokesperson acknowledged Ross had worked with other government agencies "to determine how to best hold accountable those who are evading U.S. sanctions" on Venezuela.

Abrams vowed to keep up the pressure.

"There are people who don't cooperate ... We'll go after the ship, the ship owner, the ship captain."

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US Turns Screws on Maritime Industry to Cut Off Venezuela's Oil - Voice of America

Growing collection of fallen symbols is a sign of progress, experts say – The Boston Globe

Activists, scholars, and artists at the forefront of the anti-racist movement said that symbols can be an easy out for powerful institutions still resistant to undoing systemic inequalities. But taken as a whole, they said, the growing collection of fallen symbols is a sign of true progress, an early victory in what will be a long fight for fundamental change.

If we are going to dismantle structural racism, if we are going to address the atrocities of slavery and genocide, if we are going to engage in a process of decolonization, the statues have to come down, said artist and activist Bree Newsome Bass, who in 2015 scaled a flagpole on the South Carolina State House grounds and took down the Confederate flag. I think that sometimes symbolic change is the first step, but it shouldnt be the last step.

A remarkable array of powerful institutions once resistant to calls for change have taken these first steps in recent weeks. The Washington NFL team is changing its long-criticized mascot. Mississippi is redesigning its Confederate emblem-emblazoned state flag; Richmond, the capital of the Confederacy, is removing statues of Confederate generals. Quaker Oats retired the Aunt Jemima brand. And in cities across the country and even the world statues and site names enshrining slavers and colonial settlers have been taken down, and public art declaring that Black lives matter has gone up.

The national phenomenon has not passed over Massachusetts. Bostons art commission voted to take down the Emancipation Memorial, which depicts Abraham Lincoln towering over a kneeling formerly enslaved man, and the city is weighing whether to permanently remove a statue of Christopher Columbus. The state Senate is considering replacing the Massachusetts seal and flag, which shows the disembodied arm of colonist Myles Standish wielding a sword over Wampanoag leader Massasoit, and prohibiting use of Native American images as mascots in public high schools. Community artists collaborated with the city of Boston to paint a Black Lives Matter street mural in Nubian Square. An activist group has renewed its calls for renaming Faneuil Hall.

Monica Cannon-Grant, the founder of Violence in Boston and the organizer behind some of the citys largest anti-racism protests, said she is concerned that momentum will stop there. My frustration is when white people use [symbolic change] against us. They say, We let you write Black Lives Matter in the street, and were like, Yeah, we asked for systemic change.

Still, Cannon-Grant and others voice support for the artists writing Black Lives Matter in the street and activists advocating for the removal of problematic statues. In a rapidly-changing public landscape, they said, symbols shape how we see the world and reflect who holds power in it.

I think that symbolic change is real change of sorts because of the importance of the stories we tell ourselves about personhood, nationhood, and citizenship, said Tomiko Brown-Nagin, dean of the Radcliffe Institute for Advanced Study and a professor of law and history at Harvard.

Some symbols are so noxious they perpetrate a type of violence: Confederate flags hearkening back to treason and chattel slavery still flying over state houses, for example.

While these kinds of questions might seem at once kind of cosmetic, theyre also telling us something about history and whos valued where, said poet Kevin Young, director of the Schomburg Center for Research in Black Culture.

That deeper cultural significance is what gives symbolic change its power. And, so does action backing it up.

Its not just saying Black lives matter but showing how they do. Supporting artists, supporting change, putting their money where their mouth is I think thats the thing that reveals commitment, Young added. And I think commitment is more important than sincerity.

The difference between cosmetic and authentic change may depend on where its coming from, said Christy Coleman, a public historian and executive director of the Jamestown-Yorktown Foundation.

A healthy skepticism may be in order, Coleman warned, when powerful institutions voluntarily dispense with a logo or historic site name, sometimes as a diversion. Traditional power sources will rarely give that up, or theyll give just enough to say were making progress without really doing the heavy-duty work, she said. In real movements, in real change, it is a ground-up swell.

Many of the cities that have made symbolic gestures in support of Black activists and communities in recent weeks have also declined to cut police budgets as drastically as activists had hoped Boston included. At the national level, little progress has been made so far on sweeping policy reforms that would bring criminal justice, economic, health, and educational systems in line with protesters demands.

Brown-Nagin said this is a sign that communities and institutions must be attentive to what comes next: What changes in everyday practices and policies will follow?

It is a question Raul Fernandez, a Brookline select board member and associate dean for equity, diversity, and inclusion at Boston Universitys Wheelock College, said he posed to his fellow elected officials when they decided to raise a Black Lives Matter banner. You have to understand that that is a commitment. Its also an invitation to the community to hold you accountable, he said.

In Boston, said City Councilwoman Julia Mejia, next steps should include reviewing who is given power in the city through appointments to boards and commissions, and making historic sites such as Faneuil Hall engines of economic empowerment for people of color.

Were at a point where we need to do what is hard, Mejia said. That is what these times require: to go beyond symbols and statues to repair the harm.

Congresswoman Ayanna Pressley agreed: If we are going to paint Black Lives Matter murals on the street, that declaration must also be reflected in our city budgets.

Pressley said immediate steps must include economic relief as well as educational and social services for those hit by COVID-19 within the context of structural racism; in the longer term, she is proposing sweeping criminal justice reform legislation endorsed by the Movement for Black Lives.

Seeing such changes through, activists and scholars agreed, will require constituents to hold their leaders feet to the fire.

Newsome Bass noted that it took five years for the effort to remove Confederate and colonialist symbols to gain real traction. She also warned activists to be vigilant against institutions that co-opt the language of the movement without making real change.

You just have to keep pushing, she said. These mayors are patting themselves on the back for Black Lives Matter murals, but their police officers are still brutalizing people.

For Dart Adams, 44, who was born and raised in Roxbury, questions of statuary and progress quite literally hit close to home. Adams now lives just minutes away from Park Square, where the Emancipation Memorial stands awaiting removal on an avenue named for Christopher Columbus.

He sees a parallel for the current moment in the story of another generation of Black Bostonians, the enslaved and free people who fought for and won emancipation eight decades before Lincolns national proclamation.

For 10 straight years, they fought through the legal system and petitioned and protested until they got more and more wins, he said. Until they achieved what was once unthinkable, and in 1783 slavery in Massachusetts was abolished.

Dasia Moore can be reached at dasia.moore@globe.com. Follow her on Twitter @daijmoore

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Growing collection of fallen symbols is a sign of progress, experts say - The Boston Globe