2 Stocks to Hold for the Next 20 Years – Motley Fool

As 2020 has demonstrated, the stock market can move in any direction in the short term. But as historical stock market data suggest, the stock market wields rock-solid wealth-building potential in the long run. That's why individual investors are best served by adopting a long-term mindset with a buy-and-hold strategy.

There are a number of ways to go about it. Most portfolios should own a collection of blue chip stocks, even if that simply relies on indexing, although buy-and-hold investing doesn't have to be boring. After all, investors that held onto today's blue-chip businesses before they were trendy have enjoyed awesome returns thanks to the power of compound interest.

With that in mind, investors might want to take a closer look at Dicerna Pharmaceuticals (NASDAQ:DRNA) and Fate Therapeutics (NASDAQ:FATE). The two development-stage biopharmas have much to prove, but these pharma stocks could appreciate considerably in the coming decades.

Image source: Getty Images.

First-generation cell therapies were based on chimeric antigen receptor (CAR) T cells, or CAR-T. While the approach has plenty of room for improvement, CAR-T cells have several notable drawbacks. For instance, the cell type isn't ideal for treating solid tumor cancers. Additionally, harvesting immune cells from each individual patient is a cost- and labor-intensive process that delays treatment. This all suggests it's worth exploring other immune cells as the starting point for next-generation cell therapies and new production methods, at the very least to augment the capabilities of CAR-T.

Fate Therapeutics is all-in on that line of thinking. Most of the company's 13 unique pipeline programs are based on natural killer (NK) cells, which have inherent advantages compared to other types of cell therapies. NK cells can target solid tumor cancer cells, rally the rest of the immune system to reduce tumor burden, and be dosed multiple times. The latter feature creates many new treatment opportunities, such as driving longer durations of response or being used in combination with other cell therapies.

The development-stage business has also taken the "next-generation" label seriously. Rather than harvest immune cells from patients -- a long, complicated, expensive, and risky procedure -- the company is pursuing an off-the-shelf strategy. In other words, most of the pipeline candidates are grown from master cell lines, which allows each cell therapy to be genetically engineered with reproducible edits and to be produced in batches. Fate Therapeutics estimates its approach would save weeks during crucial treatment windows and drop the cost of treatment from $425,000 per dose to just $2,500 per dose. Better yet, the approach is cell-type agnostic, meaning it can be applied to NK cells and CAR-T cells.

Although the early stage pipeline lacks concrete data for investors to digest, there are a handful of significant partnerships that boost the company's credentials. Fate Therapeutics has a collaboration with Johnson & Johnson subsidiary Janssen that could be worth up to $3 billion in milestone payments, a collaboration with ONO Pharmaceutical that could be worth over $1.3 billion in milestone payments, and a partnership with Inscripta providing access to next-generation gene-editing tools.

Fate Therapeutics ended March with $204 million in cash, which is sufficient to get the business through several data readouts from early clinical trials. If the results suggest the cell therapy approach has merit, then the biopharma stock should earn a higher valuation. Given the ambitious volume of assets -- 13 unique pipeline programs is very large for a development-stage company -- no single failure should have a disastrous effect on the stock price. Investors with a long-term mindset should give this company a closer look.

Image source: Getty Images.

Gene editing and gene therapies gobble up most of the attention when it comes to genetic medicines, but investors shouldn't forget about RNA interference (RNAi). The gene-silencing technique encountered some stumbles in the past two decades, but a few simple tweaks to how the therapeutic payload is delivered into cells appears to have resurrected the technology's intriguing potential.

Dicerna Pharmaceuticals is one of the leading investment opportunities in the space. On the one hand, the company hasn't commercialized a single pipeline asset and is relatively far behind RNAi peers Alnylam Pharmaceuticals and Arrowhead Pharmaceuticals. On the other hand, the company ended March with half its market cap in cash and partnerships with six of the world's leading pharmaceutical companies.

That includes an unusual collaboration with Alnylam Pharmaceuticals. The duo reached an agreement to co-develop competing drug candidates for alpha-1 liver disease, in which Dicerna Pharmaceuticals has the right to develop Alnylam's ALN-AAT02 and its own DCR-A1AT. The RNAi competitor-collaborators also agreed to share intellectual property for their pulmonary hypertension (PH) programs. Hefty royalties -- in both directions -- are the bounty for success.

That's not the only intriguing partnership in the pipeline. Dicerna Pharmaceuticals and Roche are developing an experimental treatment aimed at chronic hepatitis B (CHB) infections. The asset is likely being developed as a functional cure for the disease, which would follow in the footsteps of an RNAi combination therapy from peer Arrowhead Pharmaceuticals. A safe and effective functional cure for CHB could generate tens of billions of dollars in lifetime sales.

Despite the early stage nature of the pipeline, investors cannot overlook the potential of the RNAi medicines being developed by Dicerna Pharmaceuticals. The gene-silencing approach could carve out and maintain dominant market positions in various indications. Market shares might change when curative gene editing tools and gene therapies arrive, although that could take much longer than many investors expect due to several technical obstacles facing the hyped-up approaches. Investors looking for a contrarian pick in genetic medicine might want to give serious consideration to this biopharma stock.

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2 Stocks to Hold for the Next 20 Years - Motley Fool

Explained: How a Black woman saved lives without her consent and without due acknowledgement – The Indian Express

Written by Pooja Pillai | New Delhi | Updated: July 27, 2020 12:22:45 am Henrietta Lacks historical marker in Clover, Virginia. (Photo: Wikimedia Commons)

In the coming week (on August 1) is the birth centenary of Henrietta Lacks, an African American woman who made one of the most significant contributions to modern medical science without her knowledge or consent.

The story of Lacks and the HeLa cell line that was harvested from her and which still forms the basis of a lot of medical research isimportant for an understanding of the ethical issues in medical research on human subjects. This is especially so right now, given the urgency to develop an effective COVID-19 vaccine, which requires that it be tested on human cells.

Who was Henrietta Lacks?

Henrietta Lacks was an African American woman, who, according toThe Immortal Life of Henrietta Lacks(2010, Crown) by Rebecca Skloot, grew up on a tobacco farm in rural Virginia. She was married to David Lacks and had five children.

Also Read | In Covid year, why unsung heroine of DNA Rosalind Franklin needs to be remembered

On January 29, 1951, she visited the John Hopkins Hospital in Baltimore, Maryland, for the diagnosis and treatment of a lump in her abdomen. It turned out to be an aggressive form of cervical cancer. Lacks died at the age of 31 on October 4, 1951.

What is HeLa and whats so special about it?

When Lacks was at John Hopkins, her tumour was biopsied and tissues from this were used for research by Dr George Otto Gey, the head of the Tissue Culture Laboratory at the hospital. The cells were found to be growing at a remarkable rate, doubling in count in 24 hours. Their astonishing growth rate made them ideal for mass replication for use in medical research.

Prior to this, researchers had attempted to immortalise human cells in vitro, but the cells always eventually died. The HeLa cells named after the donor were the first ones to be successfully immortalised.

How have HeLa cells advanced medical science?

The HeLa cell line is one of the most important cell lines in the history of medical science and has been the foundation for some of the most significant advances in this field.

HeLa cells were the first human cells to be successfully cloned and were used by Jonas Salk to test the polio vaccine. Significantly, they helped in identifying the human papilloma virus (HPV) as being the main cause of many forms of cervical cancer including the one that killed Lacks and were instrumental in the development of the HPV vaccine, which won its creator, Harald zur Hausen, the Nobel Prize for Medicine in 2008.

Theyve been used widely in cancer research and were used to establish that human cells contain 23 pairs of chromosomes, not 24, as previously thought.

When was Lacks recognised as the donor of the HeLa cells?

Lacks was an unwitting donor; neither she, nor her family were aware that her cells had been extracted and were to be used for medical research. Lacks was a poor, uneducated Black woman and her consent was not considered necessary by the medical establishment at the time.

Also Read | Meet Dr Sarah Gilbert, one of the scientists leading the race to find a coronavirus vaccine

While thousands of studies and developments worth many billions of dollars happened due to the HeLa cells, Lacks herself was only acknowledged as their source in the 1970s when researchers sought blood samples from her family. Moreover, her descendants had no control over the cell line until 2013, when the National Institutes of Health arrived at an agreement with them, granting them a degree of control over how Lacks genetic material was to be used.

Race and non-ethical medical research

In 1947, during the Nuremberg Trials, the Allied forces developed what came to be known as the Nuremberg Code, a set of 10 ethical principles for human experimentation. The code was created in response to the German experiments on human subjects during World War II and the first principle it enshrined was that voluntary consent was essential in human experimentation.

By the time Lacks cells were harvested and used without her consent, the code had been in existence for four years. Unfortunately, the violation of Lacks consent was only the latest chapter in a long history of medical research which has scorned ethics as far as non-white bodies are concerned.

Take the case of J Marion Sims, the 19th century physician who is often called the father of modern gynecology. He pioneered the surgical treatment of the vesicovaginal fistula, a common complication of childbirth in which a tear develops between the bladder and vaginal wall, causing pain, infection and urine leakage. Sims performed his surgical experiments on Alabama slaves, without their consent and without the benefit of anaesthesia.

Or consider the infamous Tuskegee Syphilis Study, conducted by the US Public Health Service, from 1932 to 72, which examined how untreated syphilis progressed through African American men and how different it was from the way it affected white men.

Alabamas Tuskegee Institute (now Tuskegee University) was recruited for the study and the subjects 399 were infected patients and 201 uninfected control patients were all poor sharecroppers. While treatment with arsenic, bismuth and mercury was initially part of the study, the subjects were later given no treatment at all. Even after penicillin began to be widely available for use in treatment of syphilis in the 1940s, it was withheld from the subjects of the Tuskegee study. More than 100 are believed to have died; the study finally ended only after public exposure in the Washington Star.

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Unethical, non-consensual experiments on human subjects took place elsewhere too; in 2013, food historian Ian Mosby revealed highly unethical nutritional experiments conducted by the Canadian government on Aboriginal children in six residential schools between 1942 and 52.

As part of the study, malnourished children were denied adequate nutrition; parents were neither informed, nor was their consent sought.

In 2004, a senate inquiry into the experiences of Australian Aboriginal children forced into state care similarly revealed their use in medical experiments and trials, from the 1920s till as late as 1970.

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Explained: How a Black woman saved lives without her consent and without due acknowledgement - The Indian Express

COVID-19 tests: There’s an insurmountable backlog of virus tests. A rapid test could help. – NBC News

As the U.S. deals with massive delays in COVID-19 testing, doctors and scientists say another type of diagnostic test could alleviate the stress on labs. Rapid, or point-of-care, tests deliver results in just minutes, while lab-based tools can take days.

"Every day they wait is another day they need to quarantine, or if they're not, it's another day they could be infecting other people," Dr. Keith Jerome, who directs the molecular virology lab at the University of Washington medical school, said in an interview. "If you're getting results within 20 minutes, you can start taking the appropriate actions right away."

The National Institutes of Health announced Wednesday what it called an "unprecedented effort" to ramp up testing technology. Funded by $1.5 billion in federal stimulus money, the program will focus on creating rapid tests and distributing them more widely.

It's also being called for by lawmakers and top federal health officials. President Donald Trump promised more rapid testing during his briefing Tuesday. And Dr. Brett Giroir, who is overseeing the nation's COVID-19 testing, said this month that he expected 5 million additional "point-of-care" tests in July, with a goal of 20 million or more by September.

The tests produce such quick results because samples aren't sent off to labs. Instead, they're inserted directly into a machine housed at a doctor's office or a hospital. The machine does the entire analysis, so instead of hours, it takes just minutes to get results similar to rapid flu or strep tests used by most doctors.

Six point-of-care tests are authorized by the Food and Drug Administration, including two antigen tests, which look for certain proteins in the virus rather than genetic material.

As promising as the rapid tests seem to be, a significant problem prevents more doctors and clinicians from using them. Most aren't as accurate as lab-based tests, and, in some cases, they can have shockingly high rates of false negatives.

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Joseph Petrosino, director of molecular virology and microbiology at Baylor College of Medicine, compares it to eating at a fast-food joint.

"If you go to a gourmet restaurant, you don't expect your meal to be ready in five minutes," he said. "But if you're on the go and you eat fast food, the quality of food is usually a sacrifice, compared to the gourmet restaurant. That's the same thing in the testing world."

One of the more popular rapid tests, Abbott Labs' ID NOW point-of-care test, which promises results in as little as five minutes and was once touted by the White House, came under fire in recent weeks after a small study found that it returned false negatives for nearly 50 percent of certain samples compared to a rival test. While other studies found more accurate results, it was enough for the FDA to issue an alert in May. The agency has received 147 adverse event reports about the test.

"The reality is that trying to do this really fast the combination of fast and sensitive turns out to be really a challenge," said Dr. Christopher Polage, director of the clinical microbiology laboratory at Duke University Health System.

Polage said COVID-19 testing is a lengthy process. In the lab, scientists use special reagents that amplify or copy a sample's genetic material to test for the virus. The process takes several hours. When you try to short-cut it for a rapid test, you can end up trading off the test's sensitivity.

"No patient is ever going to wait at a clinic for eight hours," Polage said. "So it's really difficult and, in some cases, impossible to get an equivalent result in a fraction of the time."

Jerome said, "You have to really keep in mind that there is a trade-off that you've made for that speed, and the trade-off is they're not as sensitive, which means they're going to miss some people who actually have COVID and tell them COVID isn't there."

A point-of-care test made by Cepheid Inc. of Sunnyvale, California, which gives results in about an hour, has been shown to be nearly as accurate as lab-based tests. But scientists say that the machine is expensive and that, as with some lab-based tests, some of the reagents it uses are in short supply.

"If you can wait an hour, you can get really good results," Jerome said. "The issue with those has been just shortages of reagents, and the machine itself is just not available enough that everybody can have one." He said UW Medicine, the health care system affiliated with the University of Washington, can use it only in the emergency room, where it needs to quickly test trauma patients so doctors and nurses know what kind of protective gear they need to wear.

But some doctors say that instead of focusing on rapid tests, which are notoriously difficult to perfect both rapid strep and flu tests also have issues with accuracy the U.S. should focus on fixing capacity issues with lab-based tests, which are being slowed in part because of supply shortages.

"We have the equipment, but we can't get the reagents," Jerome said. "We did a little over 7,000 tests yesterday in my laboratory. But we could have done 7,000 more if we had full allotments of reagents."

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The delays in testing have a real impact for people like Frank Borsa, 55, who anxiously waited for days to find out whether he was infected after he returned to Brooklyn, New York, from Miami.

"It's really frustrating," Borsa said while he was still waiting for the results. "I've called repeatedly. What you get is 'it's taking a little bit longer.' It's very difficult, because you don't know how to go forward."

He finally got his results 12 days after he took the test at a New York City urgent care center. He was negative. But he said he now understands what the hubbub around testing is all about.

"Even though there might be hundreds of thousands of tests performed per day, if people are not getting their results, this is never going to end," he said. "The communication is there's tons of tests. But if there's no results, what good is it?"

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COVID-19 tests: There's an insurmountable backlog of virus tests. A rapid test could help. - NBC News

Why Black and Hispanic residents are more likely to become infected by the coronavirus – Poynter

Black and Hispanic residents are more likely than white residents to become infected by the coronavirus and Black residents are more likely to die from it. Dr. Sherita Hill Golden, vice president and chief diversity officer for Johns Hopkins Medicine, talked with me this week about why that is the case.

She discussed the impact of systemic racism, dispelled some myths and highlighted ways health care institutions and government can respond to make a difference.

Here are the highlights of our conversation, which has been edited and condensed for clarity.

Tim Nickens: Statistics show Black and Hispanic residents are more likely to become infected by the COVID-19 virus and more likely to die from it. Why is that?

Dr. Sherita Hill Golden, vice president and chief diversity officer for Johns Hopkins Medicine (Courtesy: Johns Hopkins Medicine)

Dr. Sherita Hill Golden: There are several contributing factors. I think of them in three buckets, and two of them are historical. One is that there are historical practices that were embedded in our medical and health care environments. During slavery, African American slaves were often experimented upon without their consent and without anesthesia. Even in modern-day medicine, there are some erroneous beliefs that somehow Blacks are more tolerant of pain and need less pain medication. Thats an example of a bias that still exists in the health care system that results in inadequate pain control during hospitalization.

There were also situations like the Guatemala syphilis experiment (in the 1940s) and the Tuskegee syphilis experiment (from the 1930s to 1972) where Hispanics and African Americans were withheld treatment so scientists could learn the natural history of syphilis. The Tuskegee experiment wasnt uncovered until 1972. Thats fairly recent in our countrys history. All of those things led to a distrust among minority populations of our medical system.

At the turn of the last century, there were also racial and ethnic groups that were considered biologically inferior to others African Americans, Latinos, and recent immigrants to the U.S. We know today that is absolutely not true. There is no scientific foundation that there are any groups that are genetically inferior to others.

All of those things have contributed to minority patients experiencing bias in the health care system resulting in less likelihood of seeking care and poor experiences in the health care setting. So we now have African American and Latino patients who may be getting sick but not coming into the health care system because they may have had poor experiences before, or coming to the health care system and not being believed when they are presenting symptoms of COVID-19.

Second, there is a social context, policies that have been in place in our country that started after the Civil War era that have contributed to structural and institutional racism in things like housing, jobs and education. African Americans were coming from the South to settle in cities in the north, and a lot of those neighborhoods would become redlined and African Americans were often subjected to predatory loans. City governments would stop investing in public works in those neighborhoods, stop investing in the school system, and stop investing in economic development. So today we have neighborhoods that still have a lot of housing instability, food insecurity where there isnt access to healthy foods, and a lack of access to parks for physical activity and recreation. We know those factors increase the risk of chronic diseases that have been associated with COVID-19.

The third bucket is that African American and Latino residents are more likely to be working in jobs in the service sector that are considered essential during the pandemic the food service industry, environmental services, security, public transportation. They have had to continue to go to work, often without proper personal protective equipment, especially at the beginning of the pandemic, so they were more likely to be exposed. Many of them are also living in crowded, multigenerational housing.

All of those things contribute to increased COVID exposure. Then if the population is also more likely to have a risk of diabetes, heart disease and lung disease because of these historical issues, and on top of that they are more likely to be exposed to and infected by COVID, that is going to result in worse outcomes. Its not so much that these diseases make you more susceptible to infection; its that they contribute to a poorer outcome once you get infected.

Nickens: Does it frustrate you that some believe Black and Hispanic residents are more likely to be infected by COVID-19 because of genetics?

Golden: Theres nothing genetic about being housing insecure, food insecure, or living in an environment where you have exposure to chemicals that increase your risk of chronic diseases. Those are social and institutional contributors to health that have nothing to do with a persons genetics.

Nickens: Are the lifestyle changes needed to guard against the virus harder to make in poorer neighborhoods?

Golden: They can be. Fortunately, now there are all kinds of masks available. Washing your hands frequently is critical. But if you are living in crowded housing, it can make social distancing difficult to impossible.

One thing important to recognize in the African American community is that everybody who is dying from COVID is not low-income and living in these types of circumstances. There are well-off African Americans who also have diabetes, obesity or cardiovascular disease who are dying from COVID. Even when you are in a situation where you can implement those public health practices, this population is still very much at risk.

Nickens: A lot has been written about historical stress contributing to this situation.

Golden: I think it is a significant contributor. African Americans are more likely to contract COVID and more likely to die. The Hispanic population is more likely to get COVID, but the death rate is not as high and is closer to that of white people. Part of the reason is that Hispanics who are getting infected are younger. But I also think the difference is that African Americans have been exposed to generational stress that results from dealing with discrimination in every aspect of life. Our Latino immigrant community has come to the U.S. more recently, so there hasnt been the same amount of time for that chronic stress to perhaps have as significant impact in terms of mortality.

We really should be thinking about how we eliminate that discriminatory stress for all of our vulnerable communities.

Nickens: What have you seen from the government and the medical community that has been effective in helping people of color and low-income communities deal with the virus?

Golden: Meeting people where they are in the community is key. Those who are undocumented immigrants dont have access to all of the usual benefits that citizens have. In Baltimore, we have established partnerships with community organizations and corporations to get meals delivered to them. We are also using our Johns Hopkins excess testing capacity to provide mobile testing in the community where there are hot spots.

If you are partnering with trusted community partners, they can also help you with contact tracing. People are often uncomfortable about wanting to say who they have been in contact with, but we have to know who they have been in contact with if they are infected so that we can make quarantine and isolation recommendations to stop the spread of the virus.

Nickens: Do you have any hope for positive structural change to come out of this pandemic as these disparities are highlighted?

Golden: Ive been a doctor for 26 years. When youre in medical school, youre told you are going to use this medicine to treat this disease and the patient is going to get better. Then you start practicing, and you realize there are all of these extraneous factors that contribute to the ability of the patient to get the medicine and to take the medicine. We have to really think about how we use our policies and legislation to address these structural, social determinants of health.

One fire hydrant is required for so many houses in a neighborhood. It seems like for so many houses, there should be a store where you can get affordable fresh fruits and vegetables and healthy food. How do we use our power of legislation to address these issues? As we think about good health, much of this needs to happen in collaboration with the health care system but also outside of it. Thats a very different way of thinking than when I was in medical school in the early 90s.

Nickens: From the news coverage you have seen on racial disparities regarding the virus, are there any particular points where the coverage is off-base or where journalists could be more thoughtful about how they approach the issue?

Golden: It is important for journalists to report on and raise awareness about the contribution of structural racism to the social determinants of health that are foundational to the disparities in COVID-19 and the chronic medical conditions that worsen outcomes from COVID-19. This will prevent reporting suggesting that it is just the chronic diseases and that it is the fault of the vulnerable populations for making poor health choices. I recall seeing such reports early during the pandemic, and they were very upsetting because they assume that everyone lives in an environment where they can make healthy choices; unfortunately, that is not the case.

It is also important to emphasize that it is not only poor African Americans who are dying from COVID-19 but also those who are adequately resourced, further shedding light on the generational impact of racism and the resulting stress on health.

Nickens: What have we missed in this conversation?

Golden: Im an African American physician. I have been shocked by how many people have died from COVID-19. Im flabbergasted that we could have this many deaths and a quarter of them are in my own community. My husband and I both know people who have had COVID-19 or have died from it. Its horrible, but if it can actually wake us up to think about what we really need to do to deliver adequate care to people and advocate for environmental justice, that would be a great outcome.

Dr. Sherita Hill Golden is vice president and chief diversity officer for Johns Hopkins Medicine. Her expertises include cardiovascular diseases, diabetes, diabetes mellitus, endocrinology and lipid disorders.

Tim Nickens recently retired as editor of editorials for the Tampa Bay Times. He and a colleague won the 2013 Pulitzer Prize for editorial writing that successfully persuaded Pinellas County to resume adding fluoride to drinking water. This is part of a series funded by a grant from the Rita Allen Foundation to report and present stories about the disproportionate impact of the virus on people of color, Americans living in poverty and other vulnerable groups.

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Why Black and Hispanic residents are more likely to become infected by the coronavirus - Poynter

The Islands of Ireland: Coney’s monument to paradise in Clare – Irish Examiner

Unlike most of the islands in the Fergus Estuary, Co Clare, Coney Island reveals some of its past immediately on approaching the pier. Where the other islands, such as Inishmacowney or OGradys Island, are surrounded by dense tree cover, Coney Island presents an open aspect where the start of a street can be observed. It has a somewhat austere appearance reminiscent of a Scottish island with foreboding buildings near the shore.

The old school building is adjacent to the pier where children from some of the nearby islands were schooled. This is Inisdadrom School which takes its name from the Irish word for the island - the island of the two backs. Coney and Inisdadrom appear to be coterminous, but on some maps, the Irish name refers only to a peninsula jutting out from its mainland which is cut off at high tide.

The islands character today is defined by lush green fields that are grazed by cattle. It is a little hard to get your head around the fact that the island once supported a population of 145 people (1841). The predominant name was Ginnane or Guinnane with Normoyle and Meaney also significant. With good limestone land supplemented by seaweed used as a fertiliser, the breadwinners on the island had a reliable means by which to earn a living. The sale of seaweed was also a source of income and was regularly sold to the mainland.

Coney is also distinct in that it has the ruins of two churches: one, a 6th-century structure built by St Brendan of Ardfert.

Just up from the pier, the past has assuredly caught up with Coney Island. Several old houses line the road with deciduous trees bursting through the roofs and out through the windows.

Ah, but not all of this islands its mysteries are revealed at once. Past the village, the old boreen rises and falls through the 2m hedges. They are thronged with cranesbill, dog rose, speedwell, orchids, tumbling briars, and teeming with life and energy from the activity of the bees.

The road leads on and suggests that something awaits. Surely some revelation is at hand, as Yeats was wont to say.

No second coming, but as the road reaches a summit, what has to be one of the most extraordinary views in the country from the top of the northernmost back displays itself. Looking downriver to the assemblage of other islands in the estuary, Low Island, Blackthorn Island, and Canon Island, the River Fergus is joined by the mighty Shannon and the two rivers flow on to the Atlantic 40km downstream. An incredible volume of water surges through this confluence. Looking north the view looks right down the runway at Shannon Airport with more islands in between, Deenish and Feenish. To the south, the mountains line up: Knockfeerina; the Galtees, Ballyhouras.

Far below, the traditional wooden boat known as a gandelow has pulled up on Rat Island and its two occupants set about gathering mussels. Their voices carry over the stillness, almost distinguishable.

And then the second revelation. A memorial monument, now without a plaque, was erected by the father of Captain John Foster Fitzgerald, who was killed in a cavalry charge in the Punjab, India in 1848. Foster Fitzgerald saw action with the 14th light dragoons in a mission to suppress a Sikh uprising. He was 27 when he was killed. His father, also a British army officer, had connections to the island having been born in Co Clare.

He was described on the recorded lettering as knight commander of the Bath of Carigoran family in the County Clare. It described his son thus in the words of poet Robbie Burns: None who knew him need be told/ A warmer heart death neer made cold.

The Fergus Estuary is one of several Coney islands in the country. There is one in West Cork, one in Sligo, and another at Lough Neagh. Van Morrisons famous Coney Island is not an island but is connected to the mainland by an isthmus between the villages of Ardglass and Killough.

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The Islands of Ireland: Coney's monument to paradise in Clare - Irish Examiner

Eyes turn to Ayvalk as nearby Greek islands borders shut – Hurriyet Daily News

ISTANBUL

Greek islands were once popular tourist destinations for Turkish tourists who could arrive at the picturesque hotspots just a stones throw away from Turkey. But now local officials are working on bringing local tourists to Ayvalk, a uniquely beautiful resort town reminiscent of the Greek islands.

The local officials have invited the local tourists to holiday in the resort town before summer is over, salvaging whats left of the tourism season damaged by the coronavirus pandemic.

Before the end of the summer season, come and enjoy the Nature Park as well as 22 islands, Ayvalk Mayor Mesut Ergin said.

Speaking to hlas News Agency, Ergin stated that the name of Ayvalk was Kidonia in ancient times, meaning quince, and added, Nature has offered such a beauty to Ayvalk; it has been so generous that it is our duty to protect these beauties, to preserve the historical texture to the next generations and to keep the infrastructure and the economy in a stronger way.

Ergin said that Ayvalk, which is the only tourism destination with 22 islands, is known as the Land of Winds in mythology and it is a unique opportunity for those who want to cool off on hot summer days. He that the holiday-goers can enjoy their holiday by joining the boat tours in the deep and cold waters of the islands, enjoy the appetizers made of herb varieties in the warm places of Cunda Island, eat papalina fish that is unique to the region and return to their homes with unforgettable memories.

The mayor said that the sunset, the magnificent birth of the full moon, the pleasure of hammock in the afternoon, the smell of red, pink, white and oleander flowers, pumpkin flower and stuffed mussels have very special tastes in Ayvalk, and added, Olives, olive oil and fragrant soaps are meticulously produced with special techniques. These are the most beautiful and meaningful gifts to be taken to friends after the holidays.Noting that those who came to Ayvalk for a holiday start making plans to move there, Ergin said: Each of the 22 islands in Ayvalk district has a different feature and memory. The biggest one of these islands is Ali Bey Island, also known as Cunda Island. A bridge was built in 1964 and the island connected to Lale Island and then to the district center.

This bridge is also the first such bridge built in Turkey. The other islands were declared a national park in 1995 and they were banned for settlement. These islands are reached by boats that organize tours. With its historical and cultural richness, sea and nature, Ayvalk is home to local and foreign tourists every year. In addition to hostels and boutique hotels, there are accommodation facilities for every budget, he added.

Emphasizing that besides its sea, sand and magnificent nature, Ayvalk has 4,000 buildings, 2,000 of which are registered and have a unique texture, Ergin said, There are many places to visit in Ayvalk. Those who want to spend a peaceful holiday away from the noise of the city are especially preferred. As an old Greek settlement, it is rushed by local and foreign tourists. It is necessary to take at least two or three days to visit the historical Greek houses, eytan Sofras [Devils Table], Sarmsakl Beach, Cunda Island, Taksiyarhis Church, Ayazma Church, narl Mosque and many more. Those who plan to take a sea vacation in Ayvalk prefer May and September, when the highest temperature of the season is seen. However, you can visit every season to see its historical and natural beauties.

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Eyes turn to Ayvalk as nearby Greek islands borders shut - Hurriyet Daily News

As Grand Island project stalls, massive Amazon center near Syracuse is built – Buffalo News

"The effect of this kind of project would be devastating," Dave Reilly said at the June public hearing. "This project would absolutely overwhelm the island."

The site is zoned for manufacturing but it's surrounded by more single-family homes, along with some business properties and a hotel, and the island as a whole hasn't seen a commercial development of this scale in its history.

Late last Monday afternoon, more than 50 members of a coalition of project critics protested outside Town Hall. The same group said it has collected nearly 1,000 signatures on anti-Amazon petitions and has a goal of collecting 1,000 more.

Some Grand Island residents are urging people to oppose the Amazon "Project Olive" development in the town.

Grand Island has a list of investments it wants Amazon to make in the town. Whitney has declined to make the list public while negotiations continue but sources have described it as substantial.

Finally, while Onondaga County officials made a public push for the project, their counterparts in Erie County had said little about Project Olive since February. This changed late last week when Poloncarz touted the project's value to the region in an interview with The News and at a news conference the following day.

Poloncarz said his office has worked on the project for two years and he doesn't want to see Erie County lose it.

While the amount of tax breaks Trammell Crow and Amazon would receive hasn't been made public, the developer under an anticipated payment-in-lieu-of-taxes, or PILOT, agreement would pay $51 million to Grand Island, Erie County and the Grand Island School District over 15 years.

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As Grand Island project stalls, massive Amazon center near Syracuse is built - Buffalo News

A Maine island marketed as a safe and secure haven wants $250K per week – The Real Deal

The vacation rental market isnt what it used to be before the coronavirus pandemic.

Vacation home owners across the country have recast their properties as safe and remote bases to ride out the pandemic, extended rental periods to months and even season-long, and of course upped the rental rate.

The owner of a private island in Maine took what he called a massive pivot and turned part of his island from an event space for the well-heeled into a safe and secure haven for the well-heeled, according to the New York Post.

Noah Gordon is asking $250,000 per week for the 12-acre property on House Island, which he says has safety and security in spades.

It has five beaches, views of Portland and the Casco Bay and three homes with a total of 10 bedrooms. Theres also three helicopter takeoff and landing zones, as well as deep-water anchorages that can accommodate the deep draft of modern yachts.

Gordon said he previously planned to add a yacht club, but thats now on hold. In 2017, the property hosted the wedding of Christi Pirro and Zak Schwarzman. Pirro is the daughter of Fox News personality Jeanine Pirro.

Top vacation destinations have seen a surge in demand since the pandemic hit. Wealthy New Yorkers flocked to the Hamptons beginning in March and April. Some rental owners have reportedly doubled their prices and now even wealthy folks are being priced out. [NYP] Dennis Lynch

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A Maine island marketed as a safe and secure haven wants $250K per week - The Real Deal

Dispatch: Water rescue in progress for 52-year-old man on Ohio River – The Cincinnati Enquirer

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The man was not wearing a life vest and as struggling in the water, according to dispatch.

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Campbell County and BooneCounty rescuecrews are searching for a 52-year-old man in the Ohio River nearPendery Park, according toHamilton County Dispatch.

The Coast Guard called dispatch shortly before 2 p.m. The man was not wearing a life vest and was struggling in the water, according to Hamilton County.

The identity of the man is unknown.

The Enquirer will update this story as more information becomes available.

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July 26, 2020, 8:21 a.m.

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Dispatch: Water rescue in progress for 52-year-old man on Ohio River - The Cincinnati Enquirer

Opinion: It’s Time For An Ethics Commission In The U.S. Virgin Islands – VI Consortium

Certainly feels like dj vu all over again. Virgin Islanders awoke on Wednesday to read headlines detailing the awarding of a lucrative no-bid contract to a friend/ relative of the Governor. People scratched their heads and asked what had happened to the change they had been promised and had voted for. Was it nepotism? The facts are not yet fully known and therefore it may be too soon to label it as such.

The League of Women Voters of the Virgin Islands (LWV Vi) acknowledges that in a community as small as ours, it is understandable that administrators might find it necessary on occasion to appoint relatives/friends to high positions or award contracts to them. However, we would assume that such appointments or awards had been made, as all others, on a competitive basis using specific metrics that demonstrate unequivocally that the talents and experience / expertise of the relative/friend rose above all others applying for the award or appointment. Failing that, it sure would smell like nepotism. Giving the young a chance is unquestionably a worthy goal but, again, the award must still be able to pass the smell test of nepotism.

Many mainland states have laws to prevent nepotism from occurring, while other states have conflict of interest laws that prohibit nepotism or do so through the creation of ethics commissions.

It is clear that this is long overdue for the USVI. The LWV VI has written to the senators in the 33rd Legislature urging them to enact legislation on nepotism, as most states have done. The LWV VI was heartened by the questions raised by some members of the Legislatures Finance Committee during a budget hearing over the administrations awarding of a lucrative contract to a friend/relative. It may have been completely justified or it may be nepotism. One thing is clear, however: it is time to put a stop to questionable as well as patently unethical actions by enacting laws that specifically address nepotism in no uncertain terms, along with the consequences for its violation.

Submitted Friday by the V.I. League of Women Voters.

Written by:Gwen-Marie Moolenaar, PhD, President, LWV VI

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Sea Turtles Are Hatching On Escambia’s Beaches. Their Odds Of Survival Are Not Good. – NorthEscambia.com

If you head to the beach, look out for the sea turtles. Their odds of survival are not good; Escambia County says 1 in 1000 hatchlings will survive to adulthood.

Escambia Countys seaturtlenesting season has just passed its halfway mark, with a total of 17 nests located on Perdido Key and Pensacola Beach. Fifteen nests are Loggerhead, the most commonturtleto county beaches, and the other two are rare Kemps Ridley nests.

Nesting may occur through the late summer; however, the first nests are expected to hatch in early August. Seaturtlehatchlings face many threats on their first trip to the Gulf, both natural and human-caused.

Bright artificial lights from homes, cars and businesses may disorient hatchlings, leading them away from the Gulf and into danger. Furniture, toys, holes and other obstacles on the beach may trap hatchlings or cause serious injury.

Hatchlings that dont reach the Gulf quickly are easy prey for predators and at risk of dehydration, starvation and death.

If you see a nest hatching or encounter hatchlingsturtleson the beach, call Escambia County Marine Resources at 850-426-1257. If you encounter a nestingturtle, turn off all lights and retreat a safe distance away.

Photos for NorthEscambia.com, click to enlarge.

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Sea Turtles Are Hatching On Escambia's Beaches. Their Odds Of Survival Are Not Good. - NorthEscambia.com

Jones, Orient Beach forced to turn away visitors early amid hot temps – New York Post

A slew of local beaches and state parks were forced to shut as early as around 9:30 a.m. Sunday because they had already reached capacity amid the blazing heat and coronavirus social-distancing rules.

Robert Moses State Park on Long Island was closed by 9:20 a.m., followed by such hot spots as Jones Beach, Orient Beach and Sandy Island, according to the state Department of Parks, Recreation and Historical Preservation. Bear Mountain State Park was among others shut down by 1 p.m.

The state police blocked off the entrances to some of the areas, including at Jones Beach, which had to turn visitors away by 11:50 a.m.

The beaches and parks are operating at reduced capacity because of social-distancing guidelines.

The mercury was set to hit 94 degrees with a real-feel temperature of 98 degrees in the metro area Sunday, according to Accuweather.

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One More Thing To Worry About At The Beach: Water Quality – wgbh.org

A report released Thursday suggests social distancing shouldn't be the only concern as people flock to beaches this summer.

The annual analysis of water quality at the state's beaches by the group Environment Massachusetts found testing at 257 beaches last year discovered potentially unsafe levels of fecal bacteria on at least one day. That's out of 559 beaches that were tested.

Tenean Beach in Dorchester and Kings Beach in Lynn and Swampscott had the greatest number of failing tests in the state.

"Most of our beaches in Massachsuetts are safe for swimming most of the time," said Ben Hellerstein of Environment Massachusetts. "Unfortunately, all too often our beaches are plagued with pollution that can make swimmers sick."

Hellerstein said one reason for that is outdated water infrastructure. In many places, the problem comes from storm water runoff. And in 19 communities in the state, sewage and storm water flow into the same pipes.

"These combined sewer systems can become overwhelmed during heavy storms discharging untreated sewage into nearby waterways," Hellerstein said.

"Collectively, we are still discharging about 3 billion gallons of untreated sewage into rivers and bays every year," Gabby Queenan of the nonprofit Massachusetts Rivers Alliance said.

It's a problem that's likely to become more common as climate change leads to more extreme precipitation events. And, Queenan said, it correlates to economic and racial disparities in the state.

"You are three times more likely to have combined sewer overflow infrastructure in your community if you're identified as an environmental justice community," Queenan said. "Which I think just points to the fact that some communities, honestly, have been left behind when it comes to having those resources to actually fix the infrastructure."

A bill currently before the state legislature would shine a light on such discharges.

"It would require the operators of combined sewage overflow systems to tell the public, to notify the public, when sewage is being dumped in the waters," said state Sen. Pat Jehlen, who is one of the authors of the bill.

"We don't like to know that it happens at all," Jehlen said. "But we should know when it does."

The U.S. House of Representatives is set to vote Friday on an $11 billion water infrastructure bill that Hellesterin says he hopes will provide funding to help fix some of Massachusetts' water quality trouble spots.

Beaches are closed to swimmers when they test above safe limits for bacteria. But Bruce Berman of the nonprofit Save the Harbor/Save the Bay said that beachgoers who see a posted flag that designates whether the water is safe to enter are not necessarily getting an accurate reflection of the current water quality. It takes a day for communities to get the those testing results, he said.

"If there's a red flag, it means it was dirty yesterday, not that it's dirty today," Berman said. "If you swim with a green flag, it means it's clean yesterday. But if there was a rainstorm last night, it might not be clean today."

Berman said communities should take this into account, and proactively close a beach after a heavy rain if that has historically caused poor water quality.

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One More Thing To Worry About At The Beach: Water Quality - wgbh.org

These Are the Beaches Travelers Can’t Wait to Return To – Reader’s Digest

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Southwest Floridas gentle Gulf Coast is where to find Sarasota County. Sarasota is a sophisticated coastal town, thats rich with the best of metropolitan art, music, media, performances, and galleries. Once the winter home of the Ringling Brothers Circus, Sarasota offers visitors an eclectic blend of arts and culture, history, fine dining, and of course the powder white sand of Trip Advisors 2020 Top Beach: Siesta Key. The beach itself is 99 percent pure quartz, and that pure white sand stays cool to the touch even in the Florida heat. The Gulf waters are calm and always perfect for a swim, but you can boat, fish, jet ski, and parasail, too. And all this wonderful beachside fun adds to the party atmosphere after the sun sets. Siesta Key Beach is so beautiful, its no wonder its one of the Florida beaches locals want to keep secret (although the MTV series Siesta Key may make that a lot more difficult now). Check into Sea Spray Resort, a favorite of visitors (it has a perfect five-star rating on TripAdvisor!) which puts you close to the sand and just a few blocks to all the action in town. There are beautifully landscaped grounds, a pool, and kitchenettes in the apartment-like rooms, providing everything you need for a relaxing beach vacation.

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These Are the Beaches Travelers Can't Wait to Return To - Reader's Digest

Entheogen – New World Encyclopedia

This entry covers entheogens as psychoactive substances used in religious or shamanic contexts. For general information about these substances and their use outside religious contexts, see psychedelics, dissociatives and deliriants.

An entheogen, in the strictest sense, is a psychoactive substance used in a religious or shamanic context. Historically, entheogens are derived primarily from plant sources and have been used in a variety of traditional religious practices. With the advent of organic chemistry, there now exist many synthetic substances with similar properties.

More broadly, the term entheogen is used to refer to such substances when used for their religious or spiritual effects, whether or not in a formal religious or traditional structure. This terminology is often chosen in contrast with recreational use of the same substances. These spiritual effects have been demonstrated in peer-reviewed studies (see below) though research remains problematic due to ongoing drug prohibition.

Entheogens have been used in a ritualized context for thousands of years. Examples of entheogens from ancient sources include: Greek: kykeon; African: Iboga; Vedic: Soma, Amrit. Chemicals used today as entheogens, whether in pure form or as plant-derived substances, include mescaline, DMT, LSD, psilocin, ibogaine, and salvinorin A.

The word "entheogen" is a neologism derived from two words of ancient Greek, (entheos) and (genesthai). The adjective entheos translates to English as "full of the god, inspired, possessed," and is the root of the English word "enthusiasm." The Greeks used it as a term of praise for poets and other artists. Genesthai means "to come into being." Thus, an entheogen is a substance that causes one to become inspired or to experience feelings of inspiration, often in a religious or "spiritual" manner.

The word entheogen was coined in 1979 by a group of ethnobotanists and scholars of mythology (Carl A. P. Ruck, Jeremy Bigwood, Danny Staples, Richard Evans Schultes, Jonathan Ott and R. Gordon Wasson). The literal meaning of the word is "that which causes God to be within an individual." The translation "creating the divine within" is sometimes given, but it should be noted that entheogen implies neither that something is created (as opposed to just perceiving something that is already there) nor that the experienced is within the user (as opposed to having independent existence).

It was coined as a replacement for the terms "hallucinogen" (popularized by Aldous Huxley's experiences with mescaline, published as The Doors of Perception in 1953) and "psychedelic" (a Greek neologism for "mind manifest," coined by psychiatrist Humphry Osmond, who was quite surprised when the well-known author, Aldous Huxley, volunteered to be a subject in experiments Osmond was running on mescaline). Ruck et al. argued that the term "hallucinogen" was inappropriate due to its etymological relationship to words relating to delirium and insanity. The term "psychedelic" was also seen as problematic, due to the similarity in sound to words pertaining to psychosis and also due to the fact that it had become irreversibly associated with various connotations of 1960s pop culture. In modern usage "entheogen" may be used synonymously with these terms, or it may be chosen to contrast with recreational use of the same substances.

The meanings of the term "entheogen" were formally defined by Ruck et al.:

In a strict sense, only those vision-producing drugs that can be shown to have figured in shamanic or religious rites would be designated entheogens, but in a looser sense, the term could also be applied to other drugs, both natural and artificial, that induce alterations of consciousness similar to those documented for ritual ingestion of traditional entheogens.

Since 1979, when the term was proposed, its use has become widespread in certain circles. In particular, the word fills a vacuum for those users of entheogens who feel that the term "hallucinogen," which remains common in medical, chemical and anthropological literature, denigrates their experience and the world view in which it is integrated. Use of the strict sense of the word has, therefore, arisen amongst religious entheogen users, and also amongst others who wish to practice spiritual or religious tolerance.

The use of the word "entheogen" in its broad sense as a synonym for "hallucinogenic drug" has attracted criticism on three grounds:

Ideological objections to the broad use of the term often relate to the widespread existence of taboos surrounding psychoactive drugs, with both religious and secular justifications. The perception that the broad sense of the term "entheogen" is used as a euphemism by hallucinogenic drug-users bothers both critics and proponents of the secular use of hallucinogenic drugs. Critics frequently see the use of the term as an attempt to obscure what they perceive as illegitimate motivations and contexts of secular drug use. Some proponents also object to the term, arguing that the trend within their own subcultures and in the scientific literature towards the use of term "entheogen" as a synonym for "hallucinogen" devalues the positive uses of drugs in contexts that are secular but nevertheless, in their view, legitimate.

Beyond the use of the term itself, the validity of drug-induced, facilitated, or enhanced religious experience has been questioned. The claim that such experiences are less valid than religious experience without the use of any sacramental catalyst faces the problem that the descriptions of religious experiences by those using entheogens are indistinguishable from many reports of religious experiences which, are presumed in modern times to, have been experienced without their use. Such a claim, however, depends entirely on the assumption that the reports of well-known mystics were not influenced by ingesting visionary plants, a derivation which Dan Merkur calls into question.

In an attempt to empirically answer the question about whether neurochemical augmentation through entheogens may enable religio-mystical experience, the Marsh Chapel Experiment was conducted by physician and theology doctoral candidate, Walter Pahnke, under the supervision of Timothy Leary and the Harvard Psilocybin Project. In the double-blind experiment, volunteer graduate school divinity students from the Boston area almost all claimed to have had profound religious experiences subsequent to the ingestion of pure psilocybin. In 2006, a more rigorously controlled version of this experiment was conducted at Johns Hopkins University, yielding very similar results.[1] To date there is little peer-reviewed research on this subject, due to ongoing drug prohibition and the difficulty of getting approval from institutional review boards. However, there is little doubt that entheogens can enable powerful experiences that are subjectively judged as important in a religious or spiritual context. Rather, it is the precise characterization and quantification of these experiences, and of religious experience in general, that is not yet developed.

Naturally occurring entheogens such as psilocybin and dimethyltryptamine, also known as N,N-dimethyltryptamine, or simply DMT (in the preparation ayahuasca) were discovered and used by older cultures, as part of their spiritual and religious life, as plants and agents which were respected, or in some cases revered. By contrast, artificial and modern entheogens, such as MDMA, never had a tradition of religious use.

Entheogens have been used in various ways, including as part of established religious traditions, secularly for personal spiritual development, as tools (or "plant teachers") to augment the mind,[2][3] secularly as recreational drugs, and for medical and therapeutic use.

The use of entheogens in human cultures is nearly ubiquitous throughout recorded history.

The best-known entheogen-using culture of Africa is the Bwitists, who used a preparation of the root bark of Iboga (Tabernanthe iboga).[4] A famous entheogen of ancient Egypt is the blue lotus (Nymphaea caerulea). There is evidence for the use of entheogenic mushrooms in Cte d'Ivoire (Samorini 1995). Numerous other plants used in shamanic ritual in Africa, such as Silene capensis sacred to the Xhosa, are yet to be investigated by western science.

Entheogens have played a pivotal role in the spiritual practices of American cultures for millennia. The first American entheogen to be subject to scientific analysis was the peyote cactus (Lophophora williamsii). For his part, one of the founders of modern ethno-botany, the late Richard Evans Schultes of Harvard University documented the ritual use of peyote cactus among the Kiowa who live in what became Oklahoma. Used traditionally by many cultures of what is now Mexico, its use spread throughout North America, replacing the toxic entheogen Sophora secundiflora (mescal bean). Other well-known entheogens used by Mexican cultures include psilocybin mushrooms (known to indigenous Mexicans under the Nhuatl name teonancatl), the seeds of several morning glories (Nhuatl: tlitlltzin and ololihqui) and Salvia divinorum (Mazateco: Ska Pastora; Nhuatl: pipiltzintzntli).

Indigenous peoples of South America employ a wide variety of entheogens. Better-known examples include ayahuasca (Banisteriopsis caapi plus admixtures) among indigenous peoples (such as the Urarina) of Peruvian Amazonia. Other well-known entheogens include: borrachero (Brugmansia spp); San Pedro Trichocereus spp); and various tryptamine-bearing snuffs, for example Epen (Virola spp), Vilca and Yopo (Anadananthera spp). The familiar tobacco plant, when used uncured in large doses in shamanic contexts, also serves as an entheogen in South America. Additionally, a tobacco that contains higher nicotine content, and therefore smaller doses required, called Nicotiana rustica was commonly used.

Over and above the indigenous use of entheogens in the Americas, one should also note their important role in contemporary religious movements, such as the Rastafari movement and the Church of the Universe.

The indigenous peoples of Siberia (from whom the term shaman was appropriated) have used the fly agaric mushroom (Amanita muscaria) as an entheogen. The ancient inebriant Soma, mentioned often in the Vedas, may have been an entheogen. (In his 1967 book, Wasson argues that Soma was fly agaric. The active ingredient of Soma is presumed by some to be ephedrine, an alkaloid with stimulant and (somewhat debatable) entheogenic properties derived from the soma plant, identified as Ephedra pachyclada.) However, there are also arguments to suggest that Soma could have also been Syrian Rue, Cannabis, or some combination of any of the above plants.

An early entheogen in Aegean civilization, predating the introduction of wine, which was the more familiar entheogen of the reborn Dionysus and the maenads, was fermented honey, known in Northern Europe as mead; its cult uses in the Aegean world are bound up with the mythology of the bee.

The extent of the use of visionary plants throughout European history has only recently been seriously investigated, since around 1960. The use of entheogens in Europe may have become greatly reduced by the time of the rise of Christianity. European witches used various entheogens, including thorn-apple (Datura), deadly nightshade (Atropa belladonna), mandrake (Mandragora officinarum) and henbane (Hyoscyamus niger). These plants were used, among other things, for the manufacture of "flying ointments."

The growth of Roman Christianity also saw the end of the 2,000-year-old tradition of the Eleusinian Mysteries, the initiation ceremony for the cult of Demeter and Persephone involving the use of a possibly entheogenic substance known as kykeon. Similarly, there is evidence that nitrous oxide or ethylene may have been in part responsible for the visions of the equally long-lived Delphic oracle (Hale et al. 2003).

In ancient Germanic culture, cannabis was associated with the Germanic love goddess Freya. The harvesting of the plant was connected with an erotic high festival. It was believed that Freya lived as a fertile force in the plant's feminine flowers and by ingesting them one became influenced by this divine force. Similarly, fly agaric was consecrated to Odin, the god of ecstasy, while henbane stood under the dominion of the thunder godThor in Germanic mythologyand Jupiter among the Romans (Rtsch 2003).

An ancient entheogenic substance in the Middle East is hashish. Its use by the "Hashshashin" to stupefy and recruit new initiates was widely reported during the Crusades. However, the drug used by the Hashshashin was likely wine, opium, henbane, or some combination of these, and, in any event, the use of this drug was for stupefaction rather than for entheogenic use. It has been suggested that the ritual use of small amounts of Syrian Rue is an artifact of its ancient use in higher doses as an entheogen.

Philologist John Marco Allegro has argued in his book The Sacred Mushroom and the Cross that early Jewish and Christian cultic practice was based on the use of Amanita muscaria which was later forgotten by its adherents, though this hypothesis has not received much consideration or become widely accepted. Allegro's hypothesis that Amanita use was forgotten after primitive Christianity seems contradicted by his own view that the chapel in Plaincourault shows evidence of Christian Amanita use in the 1200s.[5]

Indigenous Australians are generally thought not to have used entheogens, although there is a strong barrier of secrecy surrounding Aboriginal shamanism, which has likely limited what has been told to outsiders. There are no known uses of entheogens by the Mori of New Zealand. Natives of Papua New Guinea are known to use several species of entheogenic mushrooms (Psilocybe spp, Boletus manicus).[6]

Kava or Kava Kava (Piper Methysticum) has been cultivated for at least 3,000 years by a number of Pacific island-dwelling peoples. Historically, most Polynesian, many Melanesian, and some Micronesian cultures have ingested the psychoactive pulverized root, typically taking it mixed with water. Much traditional usage of Kava, though somewhat suppressed by Christian missionaries in the nineteenth and twentieth centuries, is thought to facilitate contact with the spirits of the dead, especially relatives and ancestors (Singh 2004).

There have been several examples of the use of entheogens in the archaeological record. Many of these researchers, like R. Gordon Wasson or Giorgio Samorini,[7][8] have recently produced a plethora of evidence, which has not yet received enough consideration within academia. The first direct evidence of entheogen use comes from Tassili, Algeria, with a cave painting of a mushroom-man, dating to 8000 BP. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices by the Scythians occurred during the fifth to second century B.C.E., confirming previous historical reports by Herodotus.

Although entheogens are taboo and most of them are officially prohibited in Christian and Islamic societies, their ubiquity and prominence in the spiritual traditions of various other cultures is unquestioned. The entheogen, "the spirit, for example, need not be chemical, as is the case with the ivy and the olive: and yet the god was felt to be within them; nor need its possession be considered something detrimental, like drugged, hallucinatory, or delusionary: but possibly instead an invitation to knowledge or whatever good the god's spirit had to offer" (Ruck and Staples).

Most of the well-known modern examples, such as peyote, psilocybe and other psychoactive mushrooms and ololiuhqui, are from the native cultures of the Americas. However, it has also been suggested that entheogens played an important role in ancient Indo-European culture, for example by inclusion in the ritual preparations of the Soma, the "pressed juice" that is the subject of Book 9 of the Rig Veda. Soma was ritually prepared and drunk by priests and initiates and elicited a paean in the Rig Veda that embodies the nature of an entheogen:

Splendid by Law! declaring Law, truth speaking, truthful in thy works, Enouncing faith, King Soma!... O [Soma] Pavmana, place me in that deathless, undecaying world wherein the light of heaven is set, and everlasting lustre shines.... Make me immortal in that realm where happiness and transports, where joy and felicities combine...

The Kykeon that preceded initiation into the Eleusinian Mysteries is another entheogen, which was investigated (before the word was coined) by Carl Kereny, in Eleusis: Archetypal Image of Mother and Daughter. Other entheogens in the Ancient Near East and the Aegean include the poppy, Datura, the unidentified "lotus" eaten by the Lotus-Eaters in the Odyssey and Narkissos.

According to Ruck, Eyan, and Staples, the familiar shamanic entheogen that the Indo-Europeans brought with them was knowledge of the wild Amanita mushroom. It could not be cultivated; thus it had to be found, which suited it to a nomadic lifestyle. When they reached the world of the Caucasus and the Aegean, the Indo-Europeans encountered wine, the entheogen of Dionysus, who brought it with him from his birthplace in the mythical Nysa, when he returned to claim his Olympian birthright. The Indo-European proto-Greeks "recognized it as the entheogen of Zeus, and their own traditions of shamanism, the Amanita and the 'pressed juice' of Soma but better since no longer unpredictable and wild, the way it was found among the Hyperboreans: as befit their own assimilation of agrarian modes of life, the entheogen was now cultivable" (Ruck and Staples). Robert Graves, in his foreword to The Greek Myths, argues that the ambrosia of various pre-Hellenic tribes were amanita and possibly panaeolus mushrooms.

Amanita was divine food, according to Ruck and Staples, not something to be indulged in or sampled lightly, not something to be profaned. It was the food of the gods, their ambrosia, and it mediated between the two realms. It is said that Tantalus's crime was inviting commoners to share his ambrosia.

The entheogen is believed to offer godlike powers in many traditional tales, including immortality. The failure of Gilgamesh in retrieving the plant of immortality from beneath the waters teaches that the blissful state cannot be taken by force or guile: when Gilgamesh lay on the bank, exhausted from his heroic effort, the serpent came and ate the plant.

Another attempt at subverting the natural order is told in a (according to some) strangely metamorphosed myth, in which natural roles have been reversed to suit the Hellenic world-view. The Alexandrian Apollodorus relates how Gaia (spelled "Ge" in the following passage), Mother Earth herself, has supported the Titans in their battle with the Olympian intruders. The Giants have been defeated:

When Ge learned of this, she sought a drug that would prevent their destruction even by mortal hands. But Zeus barred the appearance of Eos (the Dawn), Selene (the Moon), and Helios (the Sun), and chopped up the drug himself before Ge could find it.

According to The Living Torah, cannabis was an ingredient of holy anointing oil mentioned in various sacred Hebrew texts.[9] The herb of interest is most commonly known as kaneh-bosm (Hebrew: -). This is mentioned several times in the Old Testament as a bartering material, incense, and an ingredient in holy anointing oil used by the high priest of the temple. Although Chris Bennett's research in this area focuses on cannabis, he mentions evidence suggesting use of additional visionary plants such as henbane, as well.

The Septuagint translates kaneh-bosm as calamus, and this translation has been propagated unchanged to most later translations of the Hebrew Bible. However, Polish anthropologist Sula Benet published etymological arguments that the Aramaic word for hemp can be read as kannabos and appears to be a cognate to the modern word 'cannabis',[10] with the root kan meaning reed or hemp and bosm meaning fragrant. Both cannabis and calamus are fragrant, reedlike plants containing psychotropic compounds.

Although philologist John Marco Allegro has suggested that the self-revelation and healing abilities attributed to the figure of Jesus may have been associated with the effects of the plant medicines [from the Aramaic: "to heal"], this evidence is dependent on pre-Septuagint interpretation of Torah, and goes firmly against the accepted teachings of the Holy See. However Merkur contends that a minority of Christian hermits and mystics could possibly have used entheogens, in conjunction with fasting, meditation and prayer.

Allegro was the only non-Catholic appointed to the position of translating the Dead Sea Scrolls. His extrapolations are often the object of scorn due to Allegro's theory of Jesus as a mythological personification of the essence of the psychoactive sacrament, furthermore they seem to conflict with the position of the Catholic Church in regards to the exclusivity of the non-canonical practice of transubstantiation and endorsement of alcohol ingestion as the exclusive means to attain communion with God. Allegro's book, The Sacred Mushroom and the Cross, relates the development of language to the development of myths, religions and cultic practices in world cultures. Allegro believed he could prove, through etymology, that the roots of Christianity, as of many other religions, lay in fertility cults; and that cult practices, such as ingesting visionary plants (or "psychedelics") to perceive the Mind of God [Avestan: Vohu Mana], persisted into the early Christian era, and to some unspecified extent into the 1200s with reoccurrences in the 1700s and mid 1900s, as he interprets the Plaincourault chapel's fresco to be an accurate depiction of the ritual ingestion of Amanita Muscaria as the Eucharist.

The historical picture portrayed by the Entheos journal is of fairly widespread use of visionary plants in early Christianity and the surrounding culture, with a gradual reduction of use of entheogens in Christianity.[11] R. Gordon Wasson's book Soma prints a letter from art historian Erwin Panofsky asserting that art scholars are aware of many 'mushroom trees' in Christian art.[12]

The question of the extent of visionary plant use throughout the history of Christian practice has barely been considered yet by academic or independent scholars. The question of whether visionary plants were used in pre-Theodosius Christianity is distinct from evidence that indicates the extent to which visionary plants were utilized or forgotten in later Christianity, including so-called "heretical" or "quasi-" Christian groups,[13] and the question of other groups such as elites or laity within "orthodox" Catholic practice.

James Arthur asserts that the little scroll from the angel with writing on it referred to in Ezekiel 2: 8,9,10 and Ezekiel 3: 1,2,3 and Book of Revelation 10: 9,10 was the speckled cap of the Amanita Muscaria mushroom.[14]

The substance melange (spice) in Frank Herbert's Dune universe acts as both an entheogen and a geriatric medicine. Control of the supply of melange was crucial to the Empire, as it was necessary for, among other things, faster than light navigation.

Consumption of the imaginary mushroom anochi as the entheogen underlying the creation of Christianity is the premise of Philip K. Dick's last novel, The Transmigration of Timothy Archer, a theme which seems to be inspired by John Allegro's book.

Aldous Huxley's final novel, Island (1962), depicted a fictional entheogenic mushroomtermed "moksha medicine"used by the people of Pala in rites of passage, such as the transition to adulthood and at the end of life.

Bruce Sterling's Holy Fire novel refers to the religion in the future as a result of entheogens, used freely by the population.

In Stephen King's The Gunslinger, Book 1 of The Dark Tower series, the main character receives guidance after taking mescaline.

The Alastair Reynolds novel Absolution Gap features a moon under the control of a religious government which uses neurological viruses to induce religious faith.

All links retrieved August 22, 2017.

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Blade Is One of the Most Influential Movies of the Last 25 Years – ScreenCrush

Wesley Snipes didnt play Blade. He became Blade. The stories of his refusal to break character while playing Marvel Comics vampire hunter are legendary, particularly from the set of the series final film, 2004sBlade: Trinity.According to co-star Patton Oswalt, Snipes was so deepinside Blades head that after the lines of communication with director David S. Goyer broke down, the star began sending him Post-It notes signed From Blade.

While thatmight have been the most extreme example of Snipes Method dedication, he was intensely invested in the character from the beginning. In 1998, he did at least one promotional interview forBladeas Blade. Im still looking for him to this day,Snipes growls about the vampire that killed Blades mother,moments before he refers to Wesley in the third person.

Agrown man talking with utter sincerity about being found as a child byKris Kristofferson and raisedas a vampire hunter is undeniably silly. Still, this clip shows just how ahead oftheir time Snipes and the firstBladewere. In 1998, practically no one in Hollywood took comic books seriously at all, much lessthisseriously. From the perspective of 2020, its clear thatBladeis one of the most important and influential movies of the last quarter century.

Before talking aboutBladeitself, its important remember the cinematic landscape in which it was created. In 1998, comic-book movies were at their lowest ebb in years. The two DC Comics adaptations the year prior to Blades release Joel Schumachers camptacularBatman and Robin and Shaquille ONealsSteel were such critical and commercial flops that Warner Bros. wouldnt make another DC Comics movie for seven years. For all intents and purposes, the DCMovie Universe was dead.

That was still significantly better than Marvels box-office track record at that time. While the company had been one of the two biggest names in comics for more than 30 years, just one of their properties had ever been adapted into a theatrically-released feature film and it was the disastrous live-action version ofHoward the Duck. The previous attempt at a Marvel movie beforeBlade was Roger CormansFantastic Four, a production so atrocious the filmhas never been officially released to this day. In 2020, the Marvel Studios logo is practically a license to print money. Back then, it was box-office poison. (Or rather it would have been considered box-office poison if Marvel had their acts together enough to have their own movie logo at all; one wouldnt arrive until 2002sSpider-Man.)

Although Tim BurtonsBatmanhad become an enormous blockbuster in 1989, almost all the superhero and comic movies made in its wake were critical or commercial flops or both. The rare success stories 1991sThe Rocketeer, 1996sThe Phantom were period pieces. Comic books were about as far out of the zeitgeist as you could get. They did not speak to contemporary ideas, at least as far as movies were concerned. Superheroes were relics; hokey, old-fashioned adventure stories for kids.

NotBlade. This was a comic-book movie setina present-day world filled with vicious vampires and modern hip-hop and technomusic. The very first action sequence literally showers an underground rave with blood.Bladeearned its R rating unheard of in its day, and almost as rare now, even in a landscape dominated by comic-book movies with extensive blood and gore. Its hero even dropped the occasional F-bomb when the mood struck him:

Whats also evident inthe scene above is that Blade has no concern about a secret identity. He strolls into a hospital, shoots at vampires, tells off cops, and leaves with an important witness with no attempt to hide his face. This was another major break with superhero movies to that point, which were entirely consumed with Supermans and Batmans and assorted other costumed do-gooders who expended enormous energy (and screen time) disguising their true identities.

Althoughthis might not seem like a huge change, most Marvel movies followedBlades lead. The X-Men ditched the masks that had been a key part of many of the characters costumes for decades.Sam RaimisSpider-Man trilogy maintained Peter Parkers secret, but then firstIron Manended with Robert Downey Jr.s Tony Stark declaring to the world that he was his armored alter ego. From that point on, the Marvel Cinematic Universe rarely considered secret identities again.

Blades armor which debutedaboutsix months beforeThe Matrixmade leather and black overcoats the de facto costume for an entire generation of action heroes also broke from the tradition established by the Burton Batman movies of encasing superheroes in mountains of stiff latex.Wesley Snipes Blade costume is elaborate but it doesnt restrict his movement, allowing director Stephen Norringtontodelivercomplex action sequences highlightinghis stars martial-arts skills.

Lets take a look at the difference in action between BurtonsBatmanand NorringtonsBlade.During Batmansbig action finale, Michael Keaton mostly stands in place while bad guys jump and kick around him. In the most extremeexample, one of theJokers goons performs an absurd gymnastics routine,flipping down an entire hallway,then leaps at Batman with a kick. Keaton watches all of this transpire without moving a muscle, then drops the guy with one punch and some kind of Bat-gadget he extends from his hand. Fight over.It might be more accurate to call this an inaction scene.

Compare that with part of the finale fromBlade, where Snipes takes on a whole army of vampires working for the evil Deacon Frost (Stephen Dorff):

Keatons Bat-costume gave him the illusion of an outlandish comic bookphysique in exchange for all of his mobility. Snipes, in contrast, needed no help in the muscle department. When hes stripped down to the waist late in the film,he isabsolutely jacked.Huge muscles were standard operating procedure in action moviesduring theyearsdominated by Schwarzenegger, Stallone, and Van Damme. After Batman, they were far less common in comic-book movies untilBlade.

The very first shot of that fight scene shows Snipes landing in a three-point stance, amodern cliche of Marvel moviesthat was a total rarity in live-action whenSnipes did it. In general, Snipes movement as Blade was way ahead of his time. Without a bulky rubber costume, he was able tostrike with equal amounts of grace and violence,like a cross between Bruce Lee and Mikhail Baryshnikov.Superheroes of that era could sometimes look impressive at rest; thinkVal Kilmer ominous looming over the Batcave in his jet-black armor. But they rarely seemed impressive in motion. Snipes Blade looked faster and more agile than everyone else on screen. He really sold the idea that this guy is more than human.

Amusingas that in-characterinterview with Bladefrom 1998 looks,it clearly shows that all of these elements were deliberate onSnipes and Norringtons part.Playing a comic-book character is the best of all worlds because anything goes,Snipes says in Blades signature snarl during the Bladeinterview. You create a different voice, create a different look, different sound, different way of moving, talking.

Snipes concludes that interview with a prediction. I think were creating a shadow world, he says, where the bridge between what is reality and the unreal is very small. Not only didBladedo exactly that, but that shadow world (and Snipes attitude and physicality) became the template for nearly every Marvel movie that followed. Wesley Snipeshad a goofy way of showing it, buthe saw the future. InBlade, hehelped build a bridge to a new way ofbringing comic books out of the shadows.

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Blade Is One of the Most Influential Movies of the Last 25 Years - ScreenCrush

Big Tech chiefs get brief reprieve from govt hearing into their growing power – ARNnet

A congressional hearing in the United States on digital marketplace competition featuring the chief executives of four of the largest American tech companies has been rescheduled for Wednesday, a US House subcommittee said on the weekend.

The CEOs of Facebook, Amazon.com, Alphabet's Google and Apple were to have testified on Monday before the House Antitrust Subcommittee. But the hearing was postponed for the lying in state at the Capitol Building of the late Representative John Lewis, an icon of the civil rights movement.

A subcommittee announcement issued on Saturday said the session now would be held on Wednesday and that witnesses and members could appear in person or virtually.

All four tech company CEOs -- Jeff Bezos of Amazon, Tim Cook of Apple, Sundar Pichai of Alphabet and Mark Zuckerberg of Facebook -- are to appear virtually, the announcement said.

The subcommittee of the Democratic-led House Judiciary Committee is investigating whether the companies actively seek to harm and eliminate smaller rivals.

"Given the central role these corporations play in the lives of the American people, it is critical that their CEOs are forthcoming," Judiciary Committee Chairman Jerrold Nadler and David Cecilline, the subcommittee chairman, said in a joint statement.

The CEOs are expected to deflect criticism of their use of market power to damage rivals by saying they themselves face competition and by debunking claims that they are so dominant.

(Reporting by Jonathan Landay; Editing by Steve Orlofsky)

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Big Tech chiefs get brief reprieve from govt hearing into their growing power - ARNnet

Congressional antitrust probe of Big Tech expected by early fall – The Globe and Mail

A Congressional deep dive into antitrust allegations against America's largest tech companies could be released by early summer.

DAMIEN MEYER/AFP/Getty Images

A much-anticipated deep dive into antitrust allegations against four of the United States largest tech companies and recommendations on how to tame their market power could be released by late summer or early fall from the House of Representatives judiciary committees antitrust panel, senior committee aides said.

The committee has received 1.3 million documents from the companies so far, they said in a call with reporters on Thursday.

The panel will question the chief executives of Facebook Inc., Amazon.com Inc., Google parent Alphabet Inc. and Apple Inc. as part of its investigation into whether the companies business practices hurt smaller rivals. The hearing was supposed to be held on July 27 but has been delayed.

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On Thursday, Reuters reported that the CEOs will defend themselves by saying their companies face intense competition and by pushing back against claims they are dominant.

All four companies will testify voluntarily and no subpoenas have been issued, the committee aides said.

In May, Representative David Cicilline, chair of the judiciary committees antitrust panel, had demanded Jeff Bezos testify and threatened Amazon with a subpoena after reports surfaced that Amazon employees tapped data from small sellers in the companys marketplace to make decisions about the online retailer launching its own competing products, despite telling lawmakers it did not engage in such practices.

Addressing questions about the format of the high-profile hearing, the aides said, there will be a single panel with all four CEOs attending virtually. Members of the subcommittee led by Mr. Cicilline, however, will attend either in person or online.

The number of rounds of questioning is up to the discretion of the chair, one committee aide said.

Asked if the hearing would uncover new information, a senior aide said that despite the risk of companies not always answering questions fully it was important to hear from decision makers.

This is not like a normal oversight hearing, where we hear from the CEOs and move on.

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Congressional antitrust probe of Big Tech expected by early fall - The Globe and Mail

Antitrust Hearing Involving Apple Chief Tim Cook and Other Big Tech CEOs Reportedly Postponed [Update:… – MacRumors

An antitrust hearing held by the U.S. House Judiciary Antitrust Subcommittee where Apple chief Tim Cook was set to join other big tech CEOs is likely to be postponed, according to a report on Thursday.

The hearing involving Cook, Amazon CEO Jeff Bezos, Alphabet/Google CEO Sundar Pichai, and Facebook CEO Mark Zuckerberg was supposed to happen next Monday, but two sources told CNBC that it was now unlikely to take place due to a conflict with the memorial service for the late representative John Lewis.

The hearing is meant to be the culmination of a more than year-long investigation into the four tech giants. After the hearing, lawmakers plan to publish a report based on their findings and propose legislation to bring antitrust laws up to date to deal with issues unique to digital marketplaces.

A recent report by The Information underlined Cook's initial reluctance to take part in the hearing, and how under the pressure of a potential subpoena, Cook ultimately agreed to participate.

Cook is said to have spent the better part of a month preparing for the hearing, which may touch on a wide range of subjects from App Store policies to Apple's disputes with the FBI over providing methods for law enforcement to access locked devices to Apple's relationships with China.

Update: The antitrust hearing with Apple CEO Tim Cook and other tech CEOs has been officially postponed. A new date has not been announced.

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Antitrust Hearing Involving Apple Chief Tim Cook and Other Big Tech CEOs Reportedly Postponed [Update:... - MacRumors

Big tech antitrust probe report from US Congress likely by early fall – Times Now

Big tech antitrust probe report from US Congress likely by early fall  |  Photo Credit: BCCL

Washington: A much-anticipated deep dive into antitrust allegations against four of America's largest tech companies and recommendations on how to tame their market power could be released by late summer or early fall from the House of Representatives Judiciary Committee's antitrust panel, senior committee aides said. The committee has received 1.3 million documents from the companies so far, they said in a call with reporters on Thursday. The panel will question the CEOs of Facebook Inc, Amazon.com Inc, Google parent Alphabet Inc, and Apple Inc as part of its investigation into whether the companies' business practices hurt smaller rivals. The hearing was supposed to be held on July 27 but has been delayed.

On Thursday, Reuters reported that the chief executives will defend themselves by saying their companies face intense competition and by pushing back against claims they are dominant. All four companies will testify voluntarily and no subpoenas have been issued, the committee aides said. In May, Representative David Cicilline, chair of the Judiciary Committee's antitrust panel, had demanded Jeff Bezos testify and threatened Amazon with a subpoena, after reports surfaced Amazon employees tapped data from small sellers in the companys marketplace to make decisions about the online retailer launching its own competing products, despite telling lawmakers it did not engage in such practices. Addressing questions about the format of the high-profile hearing, the aides said, there will be a single panel with all four CEOs attending virtually. Members of the subcommittee led by Cicilline, however, will attend either in person or online.

"The number of rounds of questioning is up to the discretion of the chair," said one committee aide. Asked if the hearing would uncover new information, a senior aide said that despite the risk of companies not always answering questions fully it was important to hear from decision-makers. "This is not like a normal oversight hearing, where we hear from the CEO's and move on."

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Big tech antitrust probe report from US Congress likely by early fall - Times Now