AI governance and the future of humanity with the Rockefeller Foundations senior VP of innovation – The Sociable

As the progenitors of artificial intelligence, how we care for and nurture this paradigm-shifting technology will determine how it grows up alongside humanity.

There are many paths ahead for AI and society, and depending on which ones we follow, we may find ourselves on a road to peace and prosperity or one towards a dark dystopia, with several gray areas in-between.

We need to now create a new institution that can continue being the gardener for AI because AI is going to leave home soon, and we hope it becomes a productive member of society Zia Khan

Zia Khan, Senior VP of Innovation at the Rockefeller Foundation, tells The Sociablethat AI will be deeply integrated in the entire human experience and how we choose to govern it is how we will determine our future alongside it.

Whilethe Bretton Woods agreements gave birth to the rule-making institutions of the World Bank and International Monetary Fund, the Rockefeller Foundation is looking to develop a practical rule-making Bretton Woods-inspired framework to govern AI.

In October, the Foundation brought together some of the brightest technologists, economists, philosophers, and thinkers who would come away inspired to create a collection of ideas and calls to action in single report: AI+1: Shaping Our Integrated Future, based on their discussions.

The conversation wasnt always easy, said Khan, but at the core, it was a fantastic conversation, and the area we landed on was the need for governance for AI.

If left unchecked, AI could be governed by a select few elitists with their own agendas, or the AI itself could assume more autonomy towards artificial superintelligence, so who governs AI, how they govern, and on whose authority they do so are all serious issues facing humanitys future with this game-changing technology.

AI is a teenager who is about to leave home [] The teenager is starting to express its personality now Zia Khan

I put the question to Khan that if he could personify AI as a child and humans as its parents, what stage of life would AI be in right now? He indulged.

If I were to guess, I would say AI is a teenager who is about to leave home, he said.

When it was in the lab, the scientists were more or less providing for AI, feeding it and caring for it.

The teenager is starting to express its personality now its a little rebellious. We saw some applications that werent great. Some issues are coming like facial recognition that we know we need to deal with but its about to leave home, in my view.

I think its about to have this explosive proliferation into society, the Rockefeller senior VP added.

AI may be likened to a teenager right now, but unlike humans, its growth will be exponential and at lightning speed.

Whats really interesting about technology is that we learn more about humans as we understand technology Zia Khan

Continuing with the parenting metaphor, do we want to care for our artificial offspring like carpenters defining all the rules early on and following the plan or do we want to be like gardeners, allowing the algorithms to flourish within a set framework while trying to nurture them and maintain boundaries?

My view of it is that we need to now create a new institution that can continue being the gardener for AI because AI is going to leave home soon, and we hope it becomes a productive member of society, but theres a lot of ways people can go when they leave home, said Khan.

For the Rockefeller Foundation senior VP, a new institution should be created to govern AI, but what would that look like?

Should the future of AI governance be held to a democratic vote of the people, or should it be placed under the stewardship of philanthropists, technologists, or other organizations with deep pockets and agendas?

We need some political mechanism to decide what are the goals that we want as a society when AI is incorporated Zia Khan

While Khan admits that he doesnt have all the answers on who should be behind the institutions to govern AI, he is certain that they do need to exist.

Going back to the teenager metaphor, he says, When someone leaves home, theres lots of things they can do. They can go to university. They can nod-off. They can be an entrepreneur [] but we still expect them to follow some basic laws around goals that we see as a society.

We need some political mechanism to decide what are the goals that we want as a society when AI is incorporated in that, and then, how do we ensure that the technology meets those goals?

And that is one of the biggest debates going around artificial intelligence circles right now and highlighted in the AI+1 report: rules-based governance or outcome-based?

Focus too much on the rules, then you can have unexpected outcomes. A few years back, Microsoft had to kill its AI chatbot Tay after itturned into a foul-mouthed racist in less than 24 hours, and more recently OpenAI created a virtual game of hide and seek, but the AI unexpectedly broke the programs simulated laws of physics to win.

By focusing on outcomes, the rules can bend and flex within a specific framework governed and guided by what the Rockefeller Foundation senior VP sees as a need for a new institution.

I think that AI is overestimated in some cases and underestimated in other cases Zia Khan

At present, there are a lot of misconceptions about what AI can and cannot do, but as Khan points out, the more we study AI, the more we find out about ourselves.

Whats really interesting about technology is that we learn more about humans as we understand technology, he said.

For example, you still dont have a robot that can really open a door. Someone said once that when the killer robots come, all you have to do is close the door. You see all these crazy videos of robots doing flips and gymnastics its a pretty simple problem relatively speaking but friction?! they cant handle it.

He added that its in studying robots that we learned our sense of touch is about a thousand times more sensitive than we thought before similarly with our hearing and similarly with our smell.

But when it comes do decision making, right now AI is really good at the intuitive tasks that we dont think much about like recognizing languages, images, and counting things.

Human consciousness, on the other hand, keeps our minds occupied on many thoughts while juggling a plethora of emotions simultaneously in any given moment.

As we understand AI better, were actually understanding human consciousness Zia Khan

Thats something, according to Khan, that AI cant do right now, and being able to manage multiple thought processes is like an executive function that only people possess at present.

As we understand AI better, were actually understanding human consciousness, and were understanding the role of emotion in helping with our cognition, he said.

These are the interesting frontiers were learning about the human mind and human body as AI progresses.

The more we understand machines, the more we understand ourselves, and many companies working with AI are applying what theyve learned and developed to directly benefit society in truly unique ways.

And there are some groups that have figured out that their AI solutions for one industry could prove beneficial in another.

For example, the Rockefeller Foundation works with a group called DataKind a fantastic organization that has an army of volunteer data scientists who want to apply their skills to social problems, says Khan.

They identify some social problems, and they get volunteer teams to help develop tools and applications.

The Rockefeller senior VP cited DataKinds work in Haiti as an example where the team was able to optimize routes for waste disposal while maximizing pickups using AI, which in turncould be applied to community health workers in Africa who can better optimize their routes between communities.

Anytime we can find something where one solution can be applied to another problem, it just really increases the efficiency of how we can solve all the challenges that were trying to solve, said Khan.

All of these AI systems have a problem around bias, and thats something were really starting to worry about Zia Khan

While algorithms can be redistributed to serve multiple purposes, problems arise when they pass along inherent biases in the code.

All of these AI systems have a problem around bias, says Khan, adding, thats something were really starting to worry about. In many ways, these tools can just reproduce and amplify the human biases that we have.

The Rockefeller Foundation recently launched the $4 million Lacuna Fund aimed specifically at correcting the gaps and biases in data for AI solutions in order to mobilize labeled datasets that solve urgent problems in low-and-middle-income contexts globally.

The Lacuna Fund is meant to identify where are there opportunities where we can fund labeled datasets that round-out the training data available to algorithms, so that those algorithms can train themselves and remove the bias, said Khan.

COVID has laid bare a lot of the really deep and important problems Zia Khan

As AI permeates every industry and facet of society, bias will be a main issue to tackle, but moving beyond biases, this technology has the power to help make sure every human on earth is fed, clothed, and sheltered, depending on how its used and governed.

The arrival of the coronavirus pandemic has accelerated the discussion on how AI can best serve humanity and society at large.

For Khan, Something like the COVID crisis gives us the opportunity to rethink big paradigm shifts.

In some way, COVID has laid bare a lot of the really deep and important problems, and I think it has heightened the urgency to think about new solutions, he said.

The current urgency of this crisis is demanding new thinking, and I think there are opportunities to deploy and apply AI to help in those cases.

Thats going to help us learn about what AI can do, and hopefully well keep an eye on the risks and manage those risks, he added.

The disruption thats been created by COVID on so many different fronts gives us the opportunity rethink really major paradigms Zia Khan

AI will be a technology that cuts across society, and the Rockefeller senior VP believes that AI governance will be directly linked to economics.

I think theres a linkage between how we think about regulating AI and a lot of the thinking thats going on with people in economics, he said.

I think people are realizing that we need a new form of economics. The neo-liberal economic paradigm of maximizing shareholder value, not accounting for the cost and nature, etc., just isnt working.

I think we have to do some hard thinking around what is the value of data, how are we accounting for the value of data, and I think that will lead to how we think about regulating and managing AI, but also the broader economic rules, and market rules, and the role of government. I think these will be more tightly coupled going forward, he added.

How we think about managing AI will be coupled with how we think about economic models Zia Khan

For Khan, The disruption thats been created by COVID on so many different fronts gives us the opportunity rethink really major paradigms, and how we think about managing AI will be coupled with how we think about economic models.

The AI teenager is about to leave home. Will it go off and learn to do what is best for society, or will its own experiences shape it into a rebellious force of destruction?

The way forward, according to the Rockefeller Foundations senior VP of innovation, is to create a framework for governance that guides AI towards a prosperous future for humanity.

Tech arms race will give corporations, governments the ability to hack human beings: Yuval Harari at WEF

Digital Immortality and the Book of the Dead

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AI governance and the future of humanity with the Rockefeller Foundations senior VP of innovation - The Sociable

Uttam Kumar and intimations of immortality – The Hindu

In 1971, Satyajit Ray took his turn in defining what he means by a star. A star is a person on the screen who continues to be expressive and interesting even after he or she has stopped doing anything. This was as fair and ingenious a definition as any. But how long is that even after, one might want to ask. This is because the star in question is none other than Uttam Kumar, for whom that even after is a full forty years; for, not only has he stopped working, he has in fact been gone for exactly four decades to the day. And forty years in this precipitous planet and in the perfidious world of cinema is enough even for a star as titanic as Uttam to have atrophied into a historical artefact, or an academic curiosity, or a mummified cultural trophy.

But Uttams afterlife has been extraordinary. Part of it is because of learned commemoration: there are countless memoirs, nostalgic ruminations, visual revisits and cinematic histories. There are reams of felicitous homage from colleagues and co-actors, directors, technicians, distributors, theatre-owners and other luminaries from all walks of life, which has created a riveting tableau of lives Uttam had directly been able to touch, if not also transform. Part of it is because of the readiness of a gregarious culture ever ready to collapse into the past. Bring a few talkative Bengalis together and in no time at all they will be in an immersive adda about Uttam and his films; humming a song or two, replaying a scene here and there, momentarily lost in the redolence of those monochrome hours, in the imagined greatness of a golden period.

For every bit of this purportedly bhadrolok acts of retention, there are also spontaneous, streetwise displays of exuberant adoration. Land in Calcutta and you would see broadsheets, hoardings, shops, posters, books dangling with his face. In quickly disappearing atriums of single-screen theatres across the city, he is ubiquitous. Uttams smiling portrait also peeps out from sudden nooks and corners neighbourly salons, dusty tailor-shops, bare-boned photo-studios, rusty sweetshops and grimy eateries that are either in thrall of his everlasting charm or touting the honour of his visit into their midst many moons ago. The scale of Uttams easy visibility across Calcutta and towns of Bengal four decades since his death makes one singular claim: that Uttam has not only refused mortality but has made a permanent home in the collective memory of Bengal.

Uttams appeal was built not only on an edifice of feel-good, gratifying romances but on the ability of his screen persona to conform and contradict; to understand the melancholic heft of the period while also being able to navigate it gently, with dulcet humility; and without rebellion and rancour.

This is about the stardom bit. What about the performances? There are many indices. First, the institutions inaugural national award for best acting in 1967; six BFJA Awards, numerous felicitations and other displays of collective reverence from public organisations. Second, metaphorical a film by Satyajit Ray at the peak of his powers (Nayak, 1966) that was based on Uttams life and had Uttam as the protagonist. Ray has never eschewed his admiration for Uttam, calling him an unparalleled cinematic icon. Consider the following brief passage from Pico Iyers New York Review of Books essay on The Hero, which accompanied the Criterion Collection release of the film in 2018. Iyer writes, The film is anchored at every moment in Kumars performance, and to me its an astonishment[...] The beauty of Kumars Arindam Mukherjee is that he has the capacity to surprise us, again and again. He can be witty and charming and kind. As Ray and Kumar push beneath the leading mans smooth surfaces, we expect, perhaps, demons and sleepless nights; but we may not be prepared for such grace.

There is also a possible third index. Note that some of Hindi cinemas milestones: Saheb Bibi Gulam (Saheb Bibi Golam), Hum Hindustani (Bosu Poribar), Hum Dono (Uttarayan), Kala Pani (Sobar Opore), Lal Pathhar (Lal Pathor), Angoor (Bhrantibilash), Jibanmrityu (Jibon Mrityu), Chupke Chupke (Chhadmabeshi), Amar Prem (Nishipodmo), Kati Patang (Surjotopa), Anurodh (Deya Neya), Abhiman (Bilombito Loy), Bemisal (Ami She o Sokha) and Ijaazat (Jotugriha) were all remakes of Uttams films. This is to say that nine of Hindi cinemas big names Guru Dutt, Sunil Dutt, Dev Anand, Rajkumar, Sanjeev Kumar, Rajesh Khanna, Dharmendra, Amitabh Bachchan and even Naseeruddin Shah have together brought to the screen multitudinous leading characters which in their original belonged to just one actor. This might give a hint of the range and depth of Uttams original talent.

And this is not counting his stellar performances in never-remade films: Bicharak (The Judge, 1959), Shiulibari (The Townmaker, 1961), Kanna (The Cry, 1962), Sesh Onko (The Last Act, 1963) Kal Tumi Aleya (The Negotiator, 1966), Chiriakhana (The Zoo, 1967), Antony Firingee (Poet from a Foreign Land, 1967) Chowringhee (Chowronghee, 1968), Ekhane Pinjor (The Prisonhouse, 1971), Agniswar (Lord of Fire, 1975) and Baghbandi Khela (The Hunting Game, 1975) among others. This example might also give a hint as to why one kind of performative stardom travels poorly across terrains but forms a larger-than-life incarnation in their home soil: Toshiro Mifune, Alain Delon, Innokenty Smoktunovsky, Tony Leung Chiu-wai and yes, the hearth-throb Marcello Mastroianni are some other robust examples.

It is somewhat epiphanic that the quadragennial month of Uttams death falls bang in the middle of a globe-rummaging pandemic. And that gives me a final reason to reflect on why Uttams screen persona is worth revisiting. As he rose in public reckoning in the mid-1950s, Uttams stardom emerged as the key figure around which the architectonics of Bengali popular cinema announced its re-organisation. The changed circumstances of Bengals chequered years could, in the young mans ordinariness, trace the hapless new citizen, the displaced refugee, the troubling aspirations of an artiste or the youth hopelessly in love. This was the initial capital of Uttam Kumars fledgling stardom and he built unfailingly upon its wide appeal. Much of the magnetism of his 1950s melodramas hence lay in this incorporation of a self-assured, footloose, companionable figure. In fact, it was this everyman figuration which in besieged, beleaguered Bengal explored resolutions to a series of crises that could interchange what was desirable and what could be realisable. In other words, Uttams appeal was built not only on an edifice of feel-good, gratifying romances but on the ability of his screen persona to conform and contradict; to understand the melancholic heft of the period while also being able to navigate it gently, with dulcet humility; and without rebellion and rancour.

Surely, there is a lesson or two to learn from that persona as it saunters into another era forty years after his mortal frame had turned into dust.

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Uttam Kumar and intimations of immortality - The Hindu

Mystery Cults of Secret SocietiesThe Inside Story – The Great Courses Daily News

By Richard B.Spence, Ph.D., University of Idaho

There was much secrecy in the ancient world and almost all the written documents concerning the mystery cults were lost. All that is left are pieces of information around which the ancient civilizations have been reconstructed. Much of the popular perception of ancient Greek and Roman civilizations has come from Hollywood and not from any scholarly findings or writings. But it has become quite clear that the mysteries were entirely different from the actual civic life of Greece.

In ancient Greece, people were officially expected to worship the emperor. But that was not the case with mystery cults. They offered fellowship and mystical experience that was personal to everyone. They even went to the extent of making people have direct contact with the divine. Redemption, salvation, and immortality were what mystery cults sought.

The Greeks found that mystery cults had roots in Egypt and had originated there. However, this has not been established although there may be some truth in it. Modern researchers have associated mystery cults with the likes of the sinister brotherhood which was introduced and expanded by Babylonian King Nimrod or even an Indo-European proto religion. But no one has been able to prove their origins with any kind of evidence. As per William Cooper, the late American conspiracy theorist, mystery cults originated in a primitive secret society named the Dragon society or Brotherhood of the snake. But again, there is nothing to prove that.

This is a transcript from the video series The Real History of Secret Societies. Watch it now, on The Great Courses Plus.

However, these mystery cults did have some common features. Each one of them had a connection with seasonal movements like those of stars and planets and progressions like equinoxes and solstices. All of them practiced initiation ceremonies, which were tough and long most of the time. Initiation here means taking in, and the ceremonies meant taking someone into a select community. Furthermore, all communities took vows of secrecy which bound them together and protected them. These bonds between the communities were strengthened by individual group rituals, meals, dancing together, andsometimesby an orgy. There was a central myth or story to these mystery cults which invariably involved subjects of death and resurrection. It was part of the mystery as to whether this myth or story was to be taken precisely or symbolically. Some of these elements can be found, for example, in medieval passion plays. Much depended on the individual experience, but the ultimate goal was an individuals spiritual awakening and unification with god.

Although mystery cults observed a lot of secrecy, some things are known. There used to be an internal hierarchy in these mysteries. The top-most person was hierophant or apostle, who was the revealer of holy things. Ordinary people who were initiated were called mystes. One of the rituals for initiation was taking sacred objects from a chest and putting them into a basket. Although this action seems foolish, its significance lay in what it symbolized. The uninitiated do not understand. The last revelation was simple but perplexing. It involved reaping an ear of grain in silence. This was ridiculed by Christian writers and called a proof of the foolishness of the cult. They wondered why one should go through all this just for an ear of grain. But it meant a lot in the context of initiation.

As initiating a person in multiple mysteries was a common practice, cults had an inevitable influencing effect on each other, in the same way as a person belonging to the Elks, the Masons, and the Odd Fellows. For example, Eleusinian mysteries had a lot of similarities with the more mystical Samothracian cult. This cult, based on the small island of Aegean in Samothrace, revered what they called the great gods, with their names known only to the initiated. The center was held by a Demeter-like great mother, who was attended by two junior male deities. Rituals were held both outdoors and indoors with sacred objects in place. One of the premises is that Samothracian mysteries disguised a cult which was devoted to the strange goddess Hecate. Apart from other things, she practiced witchcraft and European witches would revere her as their deity. In the Shakespeare play Macbeth, Hecate who was invoked by the three sisters at the beginning of the play.

Learn more about the secret societies behind the Boston Tea Party and Bastille Day.

In the study of geometry or trigonometry, the Pythagoras theorem is well known. However, Pythagoras also founded a secret society that was based on reincarnation, vegetarianism, the immortality of the soul, and, of course, mathematics. Around 500 B.C., the Pythagorean Brotherhood came up in southern Italy. Although called a brotherhood, sometimes it initiated women too. The first three centuries of the A.D. era was the period when mystery cults bloomed most. And this was also the period when the Roman empire had its heydays. But this was no coincidence. As Rome brought most of the Mediterranean and Near East under its control, it acted as a melting pot for different religions, people, and ideas. And one of the mystery cults which was most popular in Rome was devoted to the Egyptian goddess Isis.

Like other secret societies, mystery cults were not equal. Some were preferred by the poor and downtrodden while others by the rich and affluent. But it can be concluded that mystery cults were not crazy societies who just indulged in wild sex and lust for blood. They also handled the mysteries of life and death in some way, and they provided fellowship and exclusivity. And, to top it all, how the brotherhood and sisterhood kept their vows of secrecy is truly amazing.

Learn more about the Knights Templar.

The Greeks found that mystery cults had roots in Egypt and had originated there. However, this has not been established, although there may be some truth in it. Modern researchers have associated mystery cults with the likes of the sinister brotherhood which was introduced and expanded by Babylonian King Nimrod or even an Indo-European proto religion.

Each one of them had a connection with seasonal movements like those of stars and planets and progressions like equinoxes and solstices. All of them practiced initiation ceremonies. And, above all, all communities took vows of secrecy which bound them together and protected them.

Pythagoras founded a secret society that was based on reincarnation, vegetarianism, the immortality of the soul, and, of course, mathematics. Around 500 B.C., the Pythagorean Brotherhood came up in southern Italy.

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Mystery Cults of Secret SocietiesThe Inside Story - The Great Courses Daily News

Analyst: Three Crypto Assets Are Sleeping Giants As Bitcoin Gears Up for Next Bull Run – The Daily Hodl

Crypto analyst Nicholas Merten is bullish on several large-cap cryptocurrencies that he believes will ride the waves of Bitcoins recent price action.

In a new episode of DataDash, the popular technical trader predicts small-cap cryptos of which many saw huge gains when DeFi erupted in June and July are likely to move sideways in the short term.

Bitcoin, on the other hand, is displaying all of the bullish metrics analysts have been hoping for, according to Merten.

Weve broken through resistance for the first time since 2017. This is highly significant. Everythings looking great. We had months of consolidation starting back in April against the line of resistance.

Merten thinks Ethereum is doing exactly what Ethereum should be doing after a small price drop at the beginning of the week. After turning resistance against BTC into support, he says ETH could accelerate very quickly.

Taking a look at the Bittrex chart here, the thing that Im noticing is were doing exactly what happened to gold in regards to its ratio against equities. You break out of an ascending triangle, you have a correction down to that line of previous resistance, and you make it support.

The analyst also believes XRP, which has seen little price action compared to other large-cap cryptos, appears to be due for modest gains in the short term and a larger move to the upside in the mid to long term.

We might need some more time for a full-scale consolidation until we get one of these accelerator moves, but I have no doubt that were looking for a bounce-up. If you were to take a look at the general lines of support here, were actually towards the lower band here. So I think we could get a slight accelerator move here in XRP even if we dont get a major move until later on.

Merten is particularly bullish on Litecoin, the eighth-ranked crypto by market capitalization.

To be quite frank with you guys, I think that this is a wonderful chart here. To see that were down on this lower range here, considering that even though you might have to take another few weeks of losses if this does turn back around, eventually this is going to probably start picking up. And weve seen historically that Litecoin moves big time.

A good comparison to this is the gold-to-silver ratio, silver to gold as Litecoin is to Bitcoin. And there is a very, very historical trend over the last two cycles in commodities the one were currently in now and the one previously where silver accelerates against gold, and were seeing that actually right now, ironically enough.

However, not everyone shares Mertens opinion that certain altcoins will get to bask in Bitcoins glory.

Ari Paul, the chief investment officer of BlockTower Capital, says if BTC keeps moving, it will likely dominate investors attention.

A big part of altcoins rallying for the last few months has been BTC in a tight range. In my opinion, most alts likely to underperform BTC if it breaks out in either direction.

The less liquid a coin is, the more its price is typically driven by leverage in the system. When BTC is boring, peoples greed is channeled elsewhere. More exposure, more leverage. Then when BTC is moving, it is an attractive avenue for that speculation, or when moving down, people are just generally more fearful so you get de-leveraging and less exposure to alts as well.

Featured Image: Shutterstock/Mikedrago.cz

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Analyst: Three Crypto Assets Are Sleeping Giants As Bitcoin Gears Up for Next Bull Run - The Daily Hodl

Capitalism Rears Its Ugly Truth, Again – LA Progressive

On the Battle of Ideas: Responding to the New World of COVID-19, Economic Crisis, and Anti-Racist Uprisings

That process goes hand-in-hand with working out a new type of organization, one the world is crying out for but no one has developed, not even ourselves. However, we have at least posed the question.

The abject failure of almost all governments around the world to deal with the COVID-19 pandemic is above all a crisis of capitalism, with the chaotic response of Trumps America its most repellent phenomenal form. But too narrow a focus on Trump obscures how this abject failure illustrates the essential nature of capitalism, its normal macabre workings, which are now revealed more openly. Capitalisms quest for limitless value creation and profit has itself been compared to a virus afflicting humanity. This is because capitalism puts everything else aside, exists for the moment, and destroys even the possibility of the reproduction of its own means of production including its labor force in the long run. This is the underlying explanation for the lack of medical supplies, of tests, of masks, let alone a real public health infrastructure ready to save humanity from the pandemics that are becoming more and more frequent.

From its earliest days, the capitalist system has been beset by chaotic production relations. In one sense, this leads to a total instability in workers lives, as they are thrown from overwork during boom times into mass unemployment during those crises that are endemic to the system. Even physical survival is always in question, as the unemployed can actually face starvation. As Karl Marx and Frederick Engels intone in the Communist Manifesto (1848) in an attack on the industrial bourgeoisie, the main wing of the ruling class under capitalism: It is unfit to rule because it is incompetent to assure an existence to its slave within his slavery (Marx and Engels, Collected Works [MECW] 6: 495). This is a unique feature of capitalism, even compared to earlier forms of class society. In these precapitalist class societies, tiny minorities already dominated the working people and extracted from them a surplus product, which kept the ruling class wealthy and underpinned a state to protect them. But at the same time, some precapitalist societies tried to allow the working people a minimum material existence, despite the low development of the productive forces at the time.

As Rosa Luxemburg noted more than a century ago with regard to British rule in India, imperialism under capitalism is unique in that it actually drains society dry, failing even to put enough of its profits into preserving its very means of exploitation:

Finally, the specifically capitalist method of colonization finds expression in the following striking circumstance. The British were the first conquerors of India to show a gross indifference toward the works of civilization that formed its public utilities and economic infrastructure. Arabs, Afghans and Mongols alike had initiated and maintained magnificent works of canalization, they provided the country a network of roads, built bridges across rivers and sunk wells. The Company that ruled India until 1858 (the East India Company R.L.) did not make one spring accessible, did not sink a single well, nor build a bridge for the benefit of the Indians. (Accumulation of Capital, Verso edition: 270)

While wages and living conditions then and now might be better in Western Europe or North America than in India, the basic framework is the same, that of capitalist exploitation, even to the point of draining life itself from the working people. And under capitalist slavery, Black people were literally worked to death, which led Marx to write that, even compared to Roman times, slavery reached its most hateful form in a situation of capitalist production (MECW30: 197).

If slavery was the most brutal form of exploitation under capitalism, in Capital Marx also writes of the slow death of the working class in industrialized Britain. He compares the rule of capital to the domination of a Juggernaut, a vehicle that crushes spectators beneath it in a religious festival, in what amounts to a human sacrifice:

Within the capitalist system all methods for raising the social productiveness of labour are brought into effect at the cost of the individual laborer; that all means for the development of production undergo a dialectical inversion so that they become means of domination and exploitation of the producers; they distort the worker into a fragment of a human being [Teilmenschen], they degrade him to the level of an appendage of a machine, subject him during the labour process to a despotism the more hateful for its meanness; they transform his life-time into working-time, and drag his wife and child beneath the wheels of the Juggernaut of capital. (Capital, Fowkes trans.: 799)

How true that rings at a time when US workers mainly superexploited Latinx immigrants are being forced back to work in meatpacking plants that are rife with COVID-19. Not only that. White rightwing mobs also applaud, guns in hand, the idea of going back to work, literally calling for human sacrifices on the altar of capital, all in order to get the economy moving again.

At best, most radical analysis stops here, at exposing the underlying essence of capitalism, but it is important to go beyond essence to subject, to the possibility of revolutionary change. It is so hard to imagine an alternative to capitalism that it is sometimes helpful, as Marx also does in Capital, to refer to other forms of production (169). But here I would like to go beyond the text of Capital to one of Marxs very last writings, the Ethnological Notebooks. In these 1880-82 notes on a variety of non-European societies, he records a description of an Indigenous communist society in the Americas that operates exactly the opposite of capitalism, producing a surplus product that is not surplus value and that is geared not to the reproduction of capital or the riches of a ruling class, but rather to the security and reproduction of life:

Rev. Sam. Gorman, missionary with the Laguna Pueblo Indians, in address to the Historical Society of New Mexico says: The right of property belongs to the female part of the family, and descends in that line from mother to daughter. Their land is held in common, but after a person cultivates a lot he has personal claim to it, which he can sell to one of the community Their women, generally, have control of the granary, are more provident than their Spanish neighbors about the future. Ordinarily they try to have a years provision on hand. It is only when two years of scarcity succeed each other, that Pueblos, as a community, suffer hunger. (118)

Note that in this communistic Indigenous society women retain significant social power, not only over the land, but also over the social reproduction of food. As a result, this technologically underdeveloped society was more provident than its Spanish neighbors, let alone 21st century capitalism, which cant even prepare for the epidemics its own scientists predict.

Similarly, in the Critique of the Gotha Program, Marx theorizes a first phase of communism, where workers would not receive the full proceeds of their labor because of the need for common funds to sustain the community:

He receives a certificate from society that he has furnished such-and-such an amount of labor (after deducting his labor for the common funds); and with this certificate, he draws from the societal supply of means of consumption as much as the same amount of labor cost.

This is from our new translation (by Karel Ludenhoff and me), which I am proud to report will appear as a book with PM Press next year, with Peter Hudiss introduction. That modern kind of communism Marx was theorizing would also, as in his description of the achievements of the Paris Commune of 1871, get rid of the standing army and the police, the physical force elements of the old Government (Civil War in France, MECW 22: 331).

Marx also suggests that more traditional and more modern kinds of communist organization of social life here mentioning the longstanding communism of the Russian village community and the kind of modern communism he theorized in Critique of the Gotha Program and that the Western European proletariat yearned for could link up as part of a revolutionary process. This is seen in his last published writing, the preface to the 1882 Russian edition of the Communist Manifesto: If the Russian Revolution becomes the signal for a proletarian revolution in the West, so that both complement each other, the present Russian common ownership of land may serve as the starting point for a communist development (Shanin, ed., Late Marx and the Russian Road: 139). That, ultimately, is the solution to the kind of social crisis brought on by COVID-19.

As discussed above, the COVID-19 pandemic is a capitalist crisis because capitalism is a form of society that does very little to secure the lives and health of the working people in its ruthless, limitless, and utterly impersonal drive for value creation.

But the pandemic is a capitalist crisis in a second sense. The actual destruction of human existence as a possibility is a product of the third and hopefully final stage of global capitalism, state-capitalism, which followed the competitive and then the monopoly stage, with the latter self-destructing during the Great Depression of the 1930s. First, we have seen how the Great Depression and the transformation into opposite of the Russian revolution created the basis for two forms of totalitarian state-capitalism, Nazi Germany and Stalinist Russia, each of which killed tens of millions of people in their concentration camps, mainly workers and peasants. Hitlers death camps gave the world a new, horrific word to describe his eliminationist anti-Semitism, genocide. That genocide has repeated itself, most tragically in Rwanda, Central Africa in the 1990s. Second, we have seen how state-capitalism here in the form of the somewhat progressive Roosevelt administration during World War 2 created the nuclear weapons that still threaten the existence of most forms of life on the planet. Third, we have seen how, as levels of ecological destruction escalate, state-capitalism threatens utterly to destroy human and many other forms of life on the planet.

To these we can now add a fourth form of state-capitalisms death grip on humanity, global pandemics that threaten human existence. As shown by science journalist Sonia Shah in her in her 2016 book, Pandemic, more frequent, more virulent, and more deadly epidemics have been predicted by scientists for decades. Modern state-capitalism destroys the habitat of many animals, bringing them and the diseases they carry into closer contact with humans. Modern state-capitalism also engages in the capture, trade, and global transport of a wide variety of exotic animals, bringing all kinds of species into close contact with each other and with human beings for the first time, allowing diseases to spring from species to species, acquiring greater virulence. At a more general level, modern state-capitalism is the most globalized form of capitalism ever, thus facilitating its wide and rapid spread. While each of these forms of destruction threaten to wipe out much of humanity, they also have a class and racist basis, in that the poorest and most oppressed are the most vulnerable.

The pandemic is a crisis of capitalism in a third major sense, in that it has touched off the greatest economic downturn since the 1930s. Capitalist ideologues of all stripes are working feverishly to perpetuate the fiction that the current economic crisis is only temporary (rightwingers), or that it will be more permanent (liberals and progressives), but that in either case the it is caused by COVID-19. This is a remarkably narrow notion of causality. For example, while the Minneapolis uprising was sparked by the racist police murder of George Floyd, even the liberal mayor referred in his speech both to longstanding issues of brutality and racism in the police department and to 400 years of slavery and oppression of Black people in the USA.

Another statistic that counts better those discouraged workers is the civilian labor force participation rate, i.e., the percentage of adults employed or actively seeking work. It has steadily declined over the past two decades in the USA. In April 2000 it stood at 67.3% of the working age population, but plunged to 64.6% by September 2013, in the wake of the Great Recession. Had the U.S. recovered from that recession in the way it was touted by Trump and the media, the labor force participation rate would have gone back up toward 2000 levels by 2020. It did not. Instead, on the eve of the pandemic in February 2020 it had actually declined slightly from 2013, to 63.4%, another clear indication of economic stagnation in the midst of supposed nearly full employment. Now, of course, it is in free fall. (US Bureau of Labor Statistics, Civilian Labor Force Participation Rate, June 4, 2020). Thus, the economic crisis touched off by the pandemic and based in part on longterm economic stagnation is just that, a real economic crisis from which no quick recovery can be expected. As our Call also states, In a word, stagnation rules the day. This did not result from the coronavirus; that was instead its proximate cause. Capitalism has been producing a lot of rotten fruit that was just waiting to fall.

Thus, the current situation of pandemic and economic collapse is the product of capitalist social relations in three major ways: (1) It reveals capitalisms pursuit of surplus value at any cost, with a reckless disregard for the safety of the working people it exploits, rather than just the failings of neoliberalism. (2) Global pandemics like COVID-19 will occur more frequently under the most advanced form of capitalism, state-capitalism, which has also produced genocide, nuclear weapons, and unprecedented ecological destruction. (3) The pandemic was only the immediate cause of the economic depression, in a world economy already ripe for a crisis even deeper than the Great Recession of 2008.

(An earlier version of this section was published in my June 12 article, Notes on the Black Lives Matter Uprising in Historical and Global Context, International Marxist-Humanist(June 12) )

Where does all this leave those striving for a world free of impoverishment and exploitation, of alienation and dehumanization, and of war, racism, sexism, heterosexism and environmental destruction? In one sense, we have been reeling over the past few months, locked down at home or forced to work in dangerous situations. During the lockdown, the world economy plummeted, throwing billions out of work. In India, low-wage workers have faced starvation. Some three billion people around the world lack access to water for the kind of handwashing public health officials deem necessary to mitigate the spread of COVID-19. Even in one of the richest cities in the world, Geneva, Switzerland, people lined up for a mile to receive a food donation toward the end of May.

Nonetheless, working people and youth have fought back in major ways during COVID-19 and the economic crisis. From the beginning, workers resisted attempts by capital and the state to keep production going, endangering their very lives. Here, the Italian workers, with their long militant tradition, led the way, with mass strike actions. In March, according to a report from CGIL, the main union federation,

From the Dalmine steel mills of Bergamo to those of Brescia, from the Fiat-Chrysler plants of Pomigliano in Naples to the Ilva steel plant in Genoa, from the Electrolux factory of Susegana in Treviso to many small and medium-sized companies in Veneto and Emilia Romagna, from the Amazon warehouses in the provinces of Piacenza and Rieti, to the poultry and meat processing companies in the Po Valley, there were thousands of striking workers who came out into the squares and streets, strictly at a safe distance of one meter apart from each other, as prescribed by the government decree. (Leopoldo Tartaglia, Dispatch from Italy: Class Struggle in the Time of Coronavirus,Labor Notes, March 20, 2020)

This forced the state and capital to concede, leading to better safety measures and for workers to be paid during safety-related work stoppages.

These measures, aimed at unionized workers, did not affect the most precarious and marginalized workers, many of them immigrants. It was from this kind of milieu in the USA, the oppressed Black communities of Houston and Minneapolis, that George Floyd, murdered by four Minneapolis police, emerged. Like so many Black working class women and men, Floyd was semi-unemployed due to COVID-19 at the time that police choked him to death in slow motion, in broad daylight as witnesses from the Black community looked on and pleaded for mercy. Floyds unconcscionable death has been seen as a form of lynching, but it also recalls the torture and executions carried out for centuries inside US slave plantations, where the audience was other enslaved people, and the purpose was to create dread by making an example of someone.

As many have also pointed out, the strangulation of George Floyd needs to be seen in the context of 400 years of slavery and the obdurate objective structures of racial oppression in the USA, from outright slavery, to Jim Crow, to todays mass incarceration. The poison of racism oozes through the sectors of employment, housing, education, healthcare, and policing, among others. Racialized capitalism in the US actually began under British colonialism as part of their widely-used policy of divide and rule, from Ireland, to the Indian subcontinent, to Virginia. That strategy favored one sector of the populace against another, in order to prevent class unity against the rulers. In seventeenth-century Virginia, this meant arming poor but formally free whites and giving them police power over all Black people, the vast majority of them enslaved, in order to prevent another outbreak uniting white and Black labor, as had occurred in Bacons rebellion in 1676. Todays police forces originate in part in the white militias that received rewards for capturing fugitive slaves.

But the racial history of the USA needs to be understood subjectively as much as objectively, in short, dialectically, if we are fully to grasp the current juncture. For todays rebellion on the streets can also trace itself to that uprising in early Virginia. In this sense, US history needs to be grasped as one of constant revolt and resistance in the face of racial and capitalist oppression. Here, one could mention (1) the slave revolts led by Denmark Vesey (1822) and Nat Turner (1831), (2) the whole period of Abolitionism, Civil War, and Reconstruction from the 1830s to the 1870s, (3) the southern rural Black Populists and their white allies in the 1890s, (4) the massive and socially progressive Black nationalist Garvey Movement after World War 1, (5) the mass interracial labor and Civil Rights movements of the 1930s, (6) the Civil Rights and Black liberation movements of the 1950s throughout the 1970s, and (7) the current period exemplified by the Sanders campaign against economic inequality and the development of Black Lives Matter, which preceded even the 2016 Sanders campaign, into a mass movement this spring that has drawn hundreds of thousands into the streets.

Today, as with the greatest of those previous movements, the Black masses have taken a vanguard role, but a wider movement has emerged involving youth of all races. As so many times before, the rulers and their representatives have tried to distinguish between good protestors and illegal, violent, and outside ones. Thus, after the mass rebellion against police brutality in 1965 in the Black ghetto of Watts, Los Angeles, some tried to blame Cuban agents, but even the official McCone Commission led by a former head of the CIA could find none. Similarly, todays far-right Trump administration blames leftwing agitators from the Antifa movement, although they can show no concrete examples. What is true is that hundreds of thousands came onto the streets all across the country under the slogan Black Lives Matter, that a police station was burned to the ground in Minneapolis, and that luxury shops in the Los Angeles area were attacked by protestors who scrawled slogans like eat the rich on walls. After over a week of rebellious actions across the land, all four Minneapolis police murderers were finally arrested, but this came after no less than 13,000 protestors had been detained.

The protests deepened and persisted in a way not seen since the 1960s. The Black Lives Matter Uprising has already developed into a nodal point, with facts on the ground demanding that any serious revolutionary analysis take these events as its starting point, as the beginning of a new revolutionary era with global dimensions.

Demonstrators were cruelly gassed and clubbed near the White House by direct presidential command, in order for Trump to show toughness at a photo op after it had been reported he was cowering in the basement. Even Trumps threat to use the regular army on the streets did not deter the demonstrators, but it did cause dissension within the military leadership, especially after it was reported that officials had used the term dominating the battle space. As even retired General Martin Dempsey noted in protest, the law and military tradition restrict the use of such tactics to foreign enemies. But it is equally true that two decades of endless war abroad, of occupation and torture of civilians in Iraq and elsewhere, is blowing back into the USA itself, with police forces that are militarized as never before. Another form of blowback can be seen in how Minneapolis police have received training from the US-funded occupation police force of one of the most reactionary powers in the world, Netanyahus Israel, where chokeholds and other physical pressure, i.e., torture, of Palestinian detainees is totally legal. These facts show that moves in the USA toward an authoritarian state are not limited to the Trump administration, but can also be found in liberal Minneapolis. It also underlines the need to amend our Statement of Principles in the Constitution, to include this stronger language in support of Palestine: We have always opposed Israels oppressive policies against the Palestinians and strongly support their right to an independent and territorially viable state. At the same time, we oppose all forms of anti-Semitism and support the Jewish peoples right to self-determination.

Less noticed but also extremely significant has been the resurgence of the youth movement in Hong Kong against Chinese government attempts to extinguish all democratic rights in that semi-autonomous city. As the threat of COVID-19 lifted a bit, the youth of Hong Kong were the first anywhere in the world to reassert their pre-COVID movement on a truly mass scale. Inside China, quieter dissent exists amid deepening repression, especially in Wuhan, where the regime covered up the full extent of COVID-19 for weeks, thus extending the suffering in China and the world. On June 4, the 31st anniversary of the crushing of the China-wide student and worker uprising of 1989, tens of thousands of Hong Kong youth gathered for the annual commemoration, despite the event having been banned due to COVID-19. Thwarted by popular protest in their attempts to get a series of repressive measures through the Hong Kong legislature, Chinas top leader, Xi Jinping, has decided to act directly, an extremely ominous turn. It should also be noted that the Hong Kong protests have never been only about political issues, as residents also face a precipitous increase in economic inequality, as investment capital from the rest of China has led to skyrocketing rents and other forms of heightened capitalist oppression. For its part, while some governments have issued verbal protests, unelected global capital is solidly backing Xis repressive measures, with all due cynicism: There will be some unhappy people for some time, said John L. Thornton, a former president of Goldman Sachs who has close ties with the Chinese regime, But the drum rolls, the dogs bark and the caravan moves on. Thats the political judgment (quoted in Alexandra Stevenson and Vivian Wang, Why China May Call the Worlds Bluff on Hong Kong, New York Times, June 4, 2020). Thorntons racist comparison of the Chinese people to dogs should also be noted.

This year marks the 150th anniversary of the birth of V.I. Lenin, one of historys most important Marxists. Despite some serious flaws the elitist vanguard party to lead and the single-party state he and Trotsky established after the revolution Lenin propagated to the world the notion that without revolutionary theory there can be no revolutionary movement. This was of course in the spirit of Marx himself, who completed Capital at the height of one of his most active periods of engagement with the workers movement, that of the First International. But what does it mean to develop revolutionary theory today in the wake of the myriad crises and opportunities facing us in the year 2020?

Writing in the wake of the 1960s, our founder Raya Dunayevskaya wrote of the need for revolutionaries to become philosophers of revolution. Posed at such a general level, many diverse socialists and radicals would agree. But once one looks deeper, key differences with Marxist-Humanism become clearer. In Philosophy and Revolution (1973), Dunayevskaya writes of two pitfalls to avoid, here debating about the African Revolutions of the 1960s, not with reformists, but genuine revolutionaries:

We must, however, beware of falling into traps set by mechanical materialists as well as voluntarists, by ideologues rooted in other civilizations as well as free-lancers. Although they call themselves Marxists, the vulgar materialists attribute an iron mold to economic laws: they must be sucked into the world market. The seeming opposite of vulgar materialists, the voluntarists Maoists or individualists, Existentialists or anarchists have one thing in common with those who are overwhelmed by economic laws: they believe they can order the workers to make one day equal twenty years. (pp. 218-19)

What Dunayevskaya is critiquing here are the two dominant forms of Marxist socialism of the twentieth century.

What does this mean for today, especially for those like us who talk of race, class, and revolution? The vulgar materialists, found among both Russian Stalinists and Western European social democrats, tended toward class and economic reductionism, which under Stalinism became tied to the interests of the Soviet Union as the supposed representative of the revolutionary class at a global level. This was the ultimate form of class reductionism, where the interests of the class were themselves reduced to those of the USSR. This led to the infamous example of the Popular Front during the Second World War, when the global Communist Parties basically dropped their anti-racist demands for what they called anti-fascist unity. Thus, when African Americans sought to march on Washington in 1943 to end segregation in the U.S. military, the Stalinist US Communist Party denounced it as a divisive weakening of the anti-fascist effort. (See our co-founder Charles Denbys Indignant Heart: A Black Workers Journal; Ralph Ellisons classic novel, Invisible Man, captures this period in fictionalized form.) Even in South Africa, nothing was supposed to be done against the white rulers. Since the Stalinists had long advocated Black liberation alongside the liberation of labor and had gained significant Black support, this betrayal struck deep, playing no small part in the disillusionment with all forms of Marxism after World War 2.

If the vulgar and rationalist materialism of the Stalinists and social democrats usually meant asking Blacks to wait for economic or political conditions to mature, the Maoist split from Stalinism was more voluntaristic and sometimes even irrationalist, stressing the revolutionary will, that U.S. imperialism was a paper tiger, etc. This stress on daring to struggle attracted many youths from the 1960s, including those around the Black Panther Party and the League of Revolutionary Black Workers in Detroit. Mao attacked the USSR as in league with U.S. imperialism, and noted how the French Communist Party had helped save the states effort to blunt the near-revolution of 1968 by channeling it into reformist electoral politics. This also gained him intellectual followers like Jean-Paul Sartre, Simone de Beauvoir, and Michel Foucault. But Maoist opposition to this kind of reformism, and to Russias often opportunistic aid to Third World liberation movements, led to a politics that placed opposition to Russia over everything, including Black liberation. In so doing, Maos China cruelly betrayed African revolutionaries, especially in Southern Africa in the 1970s. For example, since Russia was giving some support to the main African liberation movement in Angola, China actually aligned itself with rightwing Angolan forces opposing that movement. These forces were in fact allied with apartheid South Africa, which sent in troops to aid them. In a surprise move that exposed and thwarted this betrayal, Russia flew tens of thousands of Cuban troops to Angola at the invitation of the new liberationist government. They drove the South African racists back home. This led to another great disillusionment with Marxism on the part of Black people, especially the many who had leaned toward Maoism in that period and had been sympathetic to groups like the Panthers or the League. This was felt in intellectual circles as well, as many Black intellectuals moved away from Marxism.

Today, little of this heritage appears before us directly, although there are exceptions like Angela Daviss wrong-headed signature on a petition supporting the Iranian regime during the protests last fall. There is also a small resurgence of Maoism among todays youthful revolutionaries. More generally, the philosophical legacies of Stalinism and Maoism whether in class reductionism or in the voluntaristic politics of the revolutionary will can be found in many political movements and tendencies of today, as seen in some forms of democratic socialism, of anarchism, or of Antifa.

If we can recognize these problems and if we can instead espouse and continue to develop Marxist-Humanism, where does that leave us as an organization? Surely, we dont want to be simply critics and gadflies and we want to the best of our abilities to participate in, learn from, and help give positive direction to movements for human liberation. To be sure, we can offer these movements a deeper and more humanist theoretical perspective than most of them can develop spontaneously.

But what about ourselves as IMHO, our structure and our practice of our Marxist-Humanist principles? Does membership mean merely intellectual adherence to Marxist-Humanist principles and then working inside other movements as individuals? If so, then our organization could take the form of study groups or study circles that might have some vague or indirect influence on the wider movement. That could preserve and develop Marxist-Humanist ideas somewhat, but would it be a real organization?

Here, Lenin can assist us, via Dunayevskaya, who appreciated Lenins concept of organizational membership as not just adhering to principles or paying your dues, but active participation in a group involving more than intellectuals in a study group. As Dunayevskaya writes in Marxism and Freedom (1958), much of Lenins 1902 book What Is to Be Done? was derived from Karl Kautskys notion that Marxist intellectuals were the real leaders of the working class, which could not arrive at socialist consciousness without them. Dunayevskaya meant this as a critique of Lenin. This is the elitist core of vanguardism and it needs to be critiqued strongly by us, as it has been.

But Dunayevskaya adds, crucially,

There was an element in Lenins theory on organization which was not borrowed from the German Social Democracy, which was specifically Leninist the conception of what constitutes membership in a Russian Marxist group. Indeed, the definition did not merely rest on a phrase that only he is a member who puts himself under the discipline of the local organization. The disciplining by the local was so crucial to Lenins conception that it held primacy over verbal adherence to Marxist theory, propagandizing Marxist views, and holding a membership card. (Marxism and Freedom: 180).

And that local, at least in Dunayevskayas eyes, would if possible be comprised of working people, not just intellectuals and students, would be citywide, etc.

This point bears on our efforts to become a real organization that is not based solely on theoretical discussions, as important as they are. Im not suggesting that we go back to Lenins model, or even that of News and Letters Committees and its locals during Dunayevskayas lifetime, as we have a wider, international organization now. But the valid point Lenin makes should not be lost because of this. It is also elucidated in his 1904 critique of the circle spirit. In addition, it bears on our ongoing critique of CLR James and others who advocated decentralized forms of organization in place of the vanguard party, but thought that the Marxist group should simply support and record the creativity of the mass movements, or theorize from the sidelines. What was lacking here was an organization that would truly link theory to practice, something the world needs more than ever today.

As Dunayevskaya put it at the end of her life, in an addition to Rosa Luxemburg, Womens Liberation, and Marxs Philosophy of Revolution:

This is the further challenge to the form of organization which we have worked out as the committee-form rather than the party-to-lead. But, though committee-form and party-to-lead are opposites, they are not absolute opposites. At the point when the theoretic-form reaches philosophy, the challenge demands that we synthesize not only the new relations of theory to practice, and all the forces of revolution, but philosophys suffering, patience and labor of the negative, i.e., experiencing absolute negativity. (xxxvii)

Thus, we seek to transcend/sublate (Aufheben) this duality between vanguardism and more decentralized forms of organization. This, comrades, is one of many issues we need to grasp if we are to really develop as an organization rooted in the philosophy and principles of Marxist-Humanism. Doing so is not separate from developing ourselves theoretically, both individually and collectively, or from participating in, learning from, and grasping what is truly new in movements like the BLM Uprising. Rather, that process goes hand-in-hand with working out a new type of organization, one the world is crying out for but no one has developed, not even ourselves. However, we have at least posed the question.

Kevin AndersonThe International Marxist-Humanist

Kevin B. Andersons authored books include Marx at the Margins: On Nationalism, Ethnicity, and Non-Western Societies and Lenin, Hegel, and Western Marxism. Among his edited books are The Power of Negativity by Raya Dunayevskaya (with Peter Hudis), Karl Marx (with Bertell Ollman), The Rosa Luxemburg Reader (with P. Hudis), and The Dunayevskaya-Marcuse-Fromm Correspondence (with Russell Rockwell).

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Capitalism Rears Its Ugly Truth, Again - LA Progressive

Issuance of dematerialised securities using blockchain technology – New draft legislation published! – Lexology

Last year, the Luxembourg legislator had already amended the law of 1st August 2001 on the circulation of securities and other financial instrument (the 2001 Law) by a law of 1st March 2019 in order to clarify that account keeping institutions such as banks could offer securities accounts operated using distributed ledger technology and a number of related items, including confirmation that successive registrations of securities using distributed ledger technology have the same effects as transfers between securities accounts (e.g. regarding transfer of ownership).

The purpose of the new draft bill is essentially to introduce two changes:

1. Clarification that issuance accounts for dematerialised securities may also be kept using distributed ledger technology

When issuing dematerialised securities, it is necessary to keep a record of the number and type of securities issued in a so-called issuance account in order to enable the central account keeper or liquidation organism to verify that in securities accounts there are not more securities in circulation than securities issued. The issuance account is not a securities account, but simply a record kept for the purposes of making the aforementioned reconciliation verifications. The central account keeper or liquidation organism whose duty it is to make these verifications will be able to keep these records using distributed ledger technology. As a result all elements linked to an issuance of dematerialised securities can be kept using distributed ledger technology in the future, i.e. not only securities accounts (already possible since 2019 by virtue of the 2001 Law) but also issuance accounts.

2. Broadening of type of entities able to act as central account keeper for debt securities

Currently, only certain regulated Luxembourg service providers can act as central account keepers under the 2013 Law. Moreover, they require a specific additional license in order to be able to perform this function. This situation will remain unchanged in relation to equity securities. However, for (non-listed) debt securities, the scope of regulated service providers able to act as central account keepers will be broadened. In the future this function can be performed by any credit institution or investment firm authorised in a Member State of the European Economic Area, provided that they have appropriate control mechanisms and IT security arrangements for the purpose of keeping issuance accounts and performing the relevant tasks linked thereto such as the aforementioned reconciliation verifications. As a result issuers of non-listed debt securities governed by Luxembourg law will have a larger choice of service providers for this aspect of an issuance.

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Issuance of dematerialised securities using blockchain technology - New draft legislation published! - Lexology

Sonoco ThermoSafe Creating Industrywide PharmaPortal Platform Using IBM Blockchain Technology To Help Deliver Improved Transparency and Traceability…

ARLINGTON HEIGHTS, Ill., July 30, 2020 (GLOBE NEWSWIRE) -- Sonoco ThermoSafe, a unit of Sonoco (NYSE: SON), the largest global provider of temperature assurance packaging for pharmaceutical distribution, is building PharmaPortal, a vendor-neutral blockchain platform for use by pharmaceutical manufacturers and carriers. Built on IBM Blockchain Transparent Supply, PharmaPortal intends to address the industrys needs to trace assets across many different supply chain participants, record a single version of the truth on all events generated on a packages journey, integrate this data with that of other businesses across an industry-scale network, and provide access controls to help ensure each data owner maintains control over who can access it on the network.

The openly governed blockchain network built on open source technology will initially focus on end-to-end traceability of temperature-controlled drugs, such as vaccines, and provide an audit trail of environmental condition monitoring to help protect the efficacy of these lifesaving, life-extending and life-enhancing medicines. To help drive its development, Sonoco will invite industry leaders to collaborate on the initiative to optimize the safety and efficiency of global temperature controlled pharmaceutical distribution.

Only through the collaborative efforts of all members of the temperature controlled pharmaceutical distribution process can we achieve the safety and efficiency that the world needs from us in this critical time, said Howard Coker, president and CEO of Sonoco. An effort of this magnitude requires a high level of industry engagement to make a meaningful difference in the lives of people around the world. IBM has had success working across a number of sectors where implementing blockchain networks transformed the efficiency and effectiveness of the supply chain, and we see the same opportunities in the pharmaceutical space.

Despite improvements, the $230B cold chain pharmaceutical distribution market still suffers from inefficiencies, which cause value losses estimated at nearly $35B. These encompass lost product inventory, root cause investigation costs, clinical trial opportunity losses, product replacement costs and redundant logistics. Multiple handoffs across contracted and sub-contracted handling agents across continents create a crucial need for trusted, end-to-end visibility of pharmaceutical shipments, conditions and documents.

IBM offers deep expertise in blockchain to the pharmaceutical industry to help establish this transformational network led by Sonoco ThermoSafe," said Raj Rao, general manager, Blockchain Platforms. With Blockchain's inherent ability to track drug provenance and create an immutable record of the lifecycle of a drug and how it was handled, this open industry initiative addresses the challenges the pharmaceutical industry faces, both in sourcing and distributing drugs.

This neutral ecosystem will be especially helpful in fostering trust in the pharmaceutical air cargo market by enabling all parties in the supply chain to give and get relevant data in a highly secured, permissioned way.

As the convener of the network, Sonoco ThermoSafe intends to create a permissioned platform for the industry that will ultimately create more visibility and transparency across the pharmaceutical supply chain. With network growth in the coming months, a PharmaPortal Advisory Council will be appointed and comprised of a range of pharmaceutical industry representatives willing to participate in its development and adoption and help openly govern the network so that the solution benefits all.

About Sonoco ThermoSafe Sonoco ThermoSafe, a unit of Sonoco (NYSE: SON), is a leading global provider of temperature assurance packaging for the safe and efficient transport of pharmaceuticals, biologics, vaccines and other temperature-sensitive products. Sonoco ThermoSafe shipping solutions mitigate risk for customers and ensure product efficacy throughout the extremes of a supply chain.With operations in the Americas, Europe and Asia, Sonoco ThermoSafe has a vast product offering featuring industry-leading technology that encompasses refrigerated, frozen or controlled room temperature applications.In addition, Sonoco ThermoSafe's ISC Labs deliver individualized design and testing services and innovative packaging solutions along with qualification and validation services to meet all regulatory requirements. More information can be found at http://www.thermosafe.com.

About Sonoco Founded in 1899, Sonoco (NYSE: SON) is a global provider of a variety of consumer packaging, industrial products, protective packaging and displays and packaging supply chain services. With annualized net sales of approximately $5.4 billion, the Company has 23,000 employees working in approximately 300 operations in 36 countries, serving some of the worlds best known brands in some 85 nations. Sonoco is committed to creating sustainable products, services and programs for our customers, employees and communities that support our corporate purpose of Better Packaging. Better Life. The Company ranked first in the Packaging sector on Fortunes Worlds Most Admired Companies for 2020 as well as Barrons 100 Most Sustainable Companies. For more information, visit http://www.sonoco.com.

Photos accompanying this announcement are available at:

https://www.globenewswire.com/NewsRoom/AttachmentNg/05c8976e-af08-4061-9d56-3fa0211f6559

https://www.globenewswire.com/NewsRoom/AttachmentNg/4ad74521-b162-44e1-99d6-11ae2713d073

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Sonoco ThermoSafe Creating Industrywide PharmaPortal Platform Using IBM Blockchain Technology To Help Deliver Improved Transparency and Traceability...

Multiple zero-days in Tor have been disclosed online – TechRadar

After unsuccessfully trying to report bugs to the Tor Project for years, a security researcher has publicly disclosed two zero-day vulnerabilities which impact both the Tor network and the Tor browser.

In two recent blog posts, Dr. Neal Krawetz announced that he has decided to go public with details on multiple zero-days in Tor after the Tor Project failed to address the security issues he reported. Krawetz also plans to reveal at least three more Tor zero-days including one that can be exploited to show the real-world IP addresses of Tor servers.

Krawetz provided further insight on his difficulties dealing with the Tor Project as a security researcher over the years in a blog post, saying:

After my public shaming of the Tor Project (in 2017), they changed their web site design to make it easier to report vulnerabilities. They also opened up their bug bounty program at HackerOne. Unfortunately, while it is easier now to report vulnerabilities to the Tor Project, they are still unlikely to fix anything. I've had some reports closed out by the Tor Project as 'known issue' and 'won't fix'. For an organization that prides itself on their secure solution, it is unclear why they won't fix known serious issues.

The first of the two zero-days disclosed by Krawetz could be used by organizations and ISPs to block users from connecting to the Tor Network. To do this, they would need to scan network connections for a distinct packet signature that is unique to Tor traffic. The packet could even be used to block Tor connections from initiating which would prevent users from connecting to the service at all.

While the first zero-day could be leveraged to detect direct connections to Tor guard nodes that allow users to connect to the Tor Network, the second zero-day can be used to detect indirect connections. These connections are used to create Tor bridges which are a special type of entry point into the network that can be used when direct access to the Tor network is blocked by companies or ISPs.

According to Krawetz, connections to Tor bridges can also be easily detected using a technique similar to tracking specific TCP packets.

Now that two-zero days affecting Tor have been disclosed with the possibility of three more being disclosed in the future, Tor users in countries with oppressive regimes such as North Korea and Syria soon may be unable to use the service. Hopefully though, the Tor Project will realize the seriousness of the zero-days disclosed by Krawetz and make an effort to fix them before this can happen.

Via ZDNet

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Multiple zero-days in Tor have been disclosed online - TechRadar

Nuts and Bolts: Understanding cyber risks and commonly used tools – The New Times

Recently, one of the most popularised and confounding hacks on Twitter took place. Twitter accounts of major companies and individuals were hacked by a scam promoting bitcoin.

Twitter handles of renowned personalities such as Barack Obama, Apple, Joe Biden, Bill Gates were among those hacked accounts.

Cyber threats have increased during Covid-19 pandemic as more users embraced online lifestyle. Google recently reported blocking more than 18 million predatory emails every day, as well as 240 million daily spam messages.

At any company or business, allowing employees access to work from work may offer advantages, but it could also open the company to a host of dangers.

Many different threats lurk online, ranging from con artists who use email and the web to trick users into giving up personal information, to malicious software that can steal important company data or corrupt files.

Maintaining a good online safety policy can help one avoid these threats and keep their business safe.

Online safety or cyber safety includes minimizing vulnerabilities and threats while on the internet and maximizing user awareness on security risks to private information.

Among the most common threats include phishing scams, identity theft, ransomware, malware, viruses and other online threats.

To be safe online, awareness about threats and risks that comes with the internet is the first step.

Below are some of the commonly used online tools that will help businesses and even individuals to improve online safety:

Tor Browser Project

Tor is free and open-source software for enabling anonymous communication which prevents anyone watching your Internet connection from knowing the sites you visit or your physical location. Its free tools include a desktop browser and a proxy app for an Android device.

HTTPS Everywhere

HTTPS Everywhere is a Firefox, Chrome, and Opera extension that encrypts your communications with many major websites, making your browsing more secure. HTTPS Everywhere is a collaboration between The Tor Project and the Electronic Frontier Foundation.

DuckDuckGO

DuckDuckGo is an Internet search engine that doesnt store your search history or sell your information to advertisers that track you across the web. DuckDuckGo avoids personalized search results. Instead, it focuses on returning the best results, generated from hundreds of individual sources, including other search engines, such as Bing and Yahoo.

editor@newtimesrwanda.com

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Nuts and Bolts: Understanding cyber risks and commonly used tools - The New Times

Guest column: The next great cure might be hiding in your medicine cabinet – The Times Herald

In the race against COVID-19, biopharmaceutical firms Regeneron and Sanofi have launched clinical trials to evaluate the efficacy of their drug, Kevzara, in treating the virus' life-threatening immune complications.

Interestingly, Kevzara isn't new; it was initially approved by the FDA in 2017 as an anti-inflammatory treatment for rheumatoid arthritis.

The launch of new trials for this drug provides hope that a treatment for COVID-19 -- and a host of other serious diseases -- might already be sitting behind your pharmacist's counter. But discovering fresh ways to utilize existing drugs requires policies that encourage researchers to look for them in the first place.

Scientists have been discovering new uses for old medicines for decades. These new uses are what researchers call a new "indication."

Recently, scientists have found that several colon-cancer drugs can slow the progress of macular degeneration -- an eye condition that gradually leads to blindness. Close to 11 million Americans suffer from macular degeneration. About half of all patients treated with the new indication can see well enough to drive after five years.

Moreover, Harvard Medical School researchers are exploring the use of a common vaccine for tuberculosis in treating type 1 diabetes, an affliction with which 1.25 million U.S. residents live.

These examples notwithstanding, the potential for discovering new indications for already-approved drugs remains mostly untapped. The FDA has approved more than 20,000 prescription drug products for marketing. Any could have powerful new therapeutic applications.

Thankfully, if these new indications are out there, there's a high likelihood that U.S. biopharmaceutical researchers will find them. That's because America's robust intellectual-property laws reward innovators who invest the time and resources needed to discover whether drugs can be put to new uses.

Right now, drug makers that find a new application for an existing drug can secure a "method-of-use" patent. This new patent recognizes that the indication is completely new and the company may have exclusive rights to sell the drug for that additional use once it secures FDA approval.

In this way, method-of-use patents create a financial incentive for drug companies to spend hundreds of millions of dollars exploring new indications. Without the ability to patent new methods of use, this follow-on drug development would be a money-losing endeavor.

Unfortunately, method-of-use patents are under scrutiny from some lawmakers in Washington. They claim that drug firms use these IP protections to "game" the system and force patients to pay more for new therapies.

Such assertions fail to take into account that method-of-use patents protect only the new use of the drug, not the drug itself.

Without these IP protections, some of the greatest examples of drug repurposing would have never been possible. That includes AZT -- the very first drug approved for AIDS. The medicine, created in the 1960s, was originally intended for cancer patients.

Years later, when researchers discovered AZT's potential for treating AIDS, the drug firm Burroughs-Wellcome secured a follow-on patent, enabling the company to invest the time and money required to turn AZT into an FDA-approved drug for AIDS.

The next breakthrough cure might be a drug that's already in medicine cabinets across the country. But we need robust IP protections to help these novel indications come to fruition.

Christopher Holman is a professor at the University of Missouri-Kansas City School of Law, where his primary research focus lies at the intersection of intellectual property and biotechnology. He also serves as a senior scholar at the Center for the Protection of Intellectual Property at the Antonin Scalia Law School at George Mason University

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Guest column: The next great cure might be hiding in your medicine cabinet - The Times Herald

COVID-19 Update on Recombinant Hirudin Medicine Market Revenue and Cost Overview 2020-2026 by Manufacturers Teva Pharmaceutical, Pfizer, Pentapharm -…

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COVID-19 Update on Recombinant Hirudin Medicine Market Revenue and Cost Overview 2020-2026 by Manufacturers Teva Pharmaceutical, Pfizer, Pentapharm -...

Family Medicine Is Key to Her Career in Global Health – AAFP News

After graduating from Princeton University with an undergraduate degree in anthropology, Erin Ferenchick, M.D., spent a year as a fellow for Princeton in Africa,(www.princetoninafrica.org) performing needs assessments, securing grants and supporting project implementation to address important issues like maternal-child health for the International Rescue Committee in Somaliland. She then spent two years as executive director of PiAf, which offers fellowships in public health, education, conservation, social entrepreneurship and microfinance.

"I enjoyed the work, but I realized I needed a more solid and tailored technical skill set to contribute in a sustainable and impactful way, so I went to medical school," Ferenchick said. "I chose family medicine because it gave me the broadest skill set, was the specialty most focused both on the patient and the broader community, and allowed me to leverage a career in global health. I've tried to keep one foot in the clinical world and one foot in global health, which is more focused on policy and programming. It's not always an easy balance to meet."

Ferenchick's clinical role is as an assistant clinical professor of medicine in the Center for Family and Community Medicine at her alma mater, Columbia University Medical Center. The pandemic has temporarily restricted her ability to travel regularly to New York for patient care, so she is now teaching and mentoring students and residents remotely from Geneva, where her public health role is based as a primary health care technical advisor for the Global Fund to Fight AIDS, Tuberculosis and Malaria.(www.theglobalfund.org)

"I have had good fortune in that Columbia values me both as a clinician and in my role as a public health advocate and the larger work I do in health systems strengthening," she said.

With the Global Fund, Ferenchick's role involves supporting countries' strategic investments in building resilient and sustainable systems for health with an emphasis on strengthening primary care to improve health outcomes for HIV, TB and malaria. Before taking her current role in 2018, she had worked as a long-term consultant not only for the Global Fund but also the World Health Organization and Gavi, the Vaccine Alliance.

Ferenchick will share her insights on working with governments and global health financing institutions, including the Global Fund, during the virtual Global Health Summit Sept. 16-18.

"There are a lot of family physicians interested in global medicine, and they find opportunities for short-term exchange programs or mentoring and teaching roles," she said. "But I don't think many are fully aware of the possibilities of engaging with these larger institutions."

The Global Fund invests more than $4 billion a year to support programs in more than 100 countries. For example, Ferenchick worked on an adolescent health project in the Democratic Republic of the Congo that allowed health care workers to participate in a monthly collaborative learning experience aimed at strengthening their skill sets specific to caring for adolescent patients with respectful and clinically sound care. The Global Fund provided financial resources and technical support for the implementation of the project as part of its larger scope of work on reducing the vulnerability of adolescents, particularly girls and young women, to HIV. The World Health Organization will be conducting an evaluation of the project to assess its impact in the coming months, she said.

Doing such work, Ferenchick said, requires both clinical and public health perspectives.

"Family medicine is very rooted in the principles of people-centered care," she said. "Family physicians have an important voice in steering the direction we invest in both domestic and global health, specifically in primary health care, to meet patients' complex and many needs. COVID-19 has shown us the importance of primary health care and what happens when primary health care systems are weak."

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Family Medicine Is Key to Her Career in Global Health - AAFP News

The National Academy of Sports Medicine (NASM) and the Athletics and Fitness Association of America (AFAA) Announce All-Virtual 2020 Optima Conference…

"The future of fitness requires adaptability. Taking Optima to an all-virtual format offers an opportunity to connect our community with the tools and knowledge to succeed in this rapidly changing world," said Laurie McCartney, President of NASM and AFAA. "By bringing together the brightest minds in the fitness industry, and using the latest technology, we will connect our trainers and instructors with insights and real-world strategies that will elevate their expertise."

The four-day event includes over 70 educational sessions, guided workouts, and valuable opportunities for the fitness community to network with thought-leaders, sponsors, and exhibitors in a state-of-the-art virtual environment.

Randy Hetrick, the founder of TRX and a former U.S. Navy Seal, will serve as the keynote speaker. As the creator of the versatile and portable TRX suspension training system, Hetrick is a leading pioneer in virtual training.

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The National Academy of Sports Medicine (NASM) and the Athletics and Fitness Association of America (AFAA) Announce All-Virtual 2020 Optima Conference...

Alumnus donates $5 million to the Lewis Katz School of Medicine – Temple University News

Renowned cardiac surgeon Gerald M. Lemole, MED 62, and Emily Jane Lemole have established the Lemole Center for Integrated Lymphatics Research at the Lewis Katz School of Medicine with a transformational donation of $5 million.

Temple University is home to world-class research that improves the health and lives of people every day. This very generous gift by Dr. Gerald Lemole and Emily Jane Lemole adds another vital area of research, said Temple University President Richard M. Englert. I am deeply grateful to the Lemoles, and on behalf of everyone at Temple University, want to thank them for their thoughtfulness and generosity.

A part of the immune system, the lymphatic system is a network of organs and nodes that help the body regulate fluid and fight illness.

The Lemole Center will serve as an interdisciplinary hub to further understanding of the lymphatic system and the part it plays in cardiac, neural and vascular diseases. By integrating basic science and clinical research, the center will promote the translation of new knowledge from the laboratory to the bedside, where it can inform patient treatment and care.

We are grateful to the administration of the Lewis Katz School of Medicine and congratulate them for their visionary approach to lymphatics research, which has always been studied adjunctively as an access route for other systems rather than the unifying, facilitating, actively integrated bedrock system that it is, said Lemole.

Led by Michael Autieri, associate director and professor in the Cardiovascular Research Center, the new collaborative center will bring together experts from around the region, nation and world to share scientific breakthroughs.

Since his early days as a doctor, Lemole has been fascinated by the lymphatic system and its role in overall health and wellness. He is the author of many publications on lymphatics for both a professional and general audience, including The Healing Diet: A Total Health Program to Purify Your Lymph System and Reduce the Risk of Heart Disease, Arthritis and Cancer.

In 1968, Lemole was part of the team that performed the first heart transplant in the U.S. The following year, he completed the first coronary bypass in the tri-state area and was named chief of cardiothoracic surgery at Temple. In 1975, at age 38, with his appointment to full professor of surgery at Temple, he became one of the youngest in the country to hold such a position.

Lemole went on to serve as chief of surgery at Deborah Heart and Lung Center in New Jersey, chief of cardiovascular surgery at the Medical Center of Delaware, and medical director at Christiana Cares Preventive Medicine and Rehabilitation Institute and Center for Integrative Health.

Emily Jane Asplundh Lemole is a former trustee of the Fund for West Chester University of Pennsylvania, a former commissioner of Lower Moreland Township, Pennsylvania, and a minister in the Swedenborgian Church of North America.

A combination of Dr. and Mrs. Lemoles forward-looking philanthropy and leadership has led to this watershed moment at the Lewis Katz School of Medicine, said John M. Daly, the Harry C. Donahoo Professor of Surgery and interim dean at Katz. This type of transformative philanthropy shapes institutions and accelerates science.

Long-time friends of the medical school, the couple previously established the Lemole Lecture Series in Integrative Medicine Fund and named the Dr. Gerald M. and Emily Jane Lemole Executive Conference Room at the Medical Education and Research Building.

Dr. and Mrs. Lemole have been an integral part of Temples story for decades, and this extraordinary relationship has led to a transformative philanthropic investment in the Lewis Katz School of Medicine, said Nina Weisbord, chief advancement officer for Temple University Health System and assistant dean at Katz. We are incredibly grateful for their enduring commitment, vision, partnership and support.

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Alumnus donates $5 million to the Lewis Katz School of Medicine - Temple University News

Generations News: Medicine tips and more – Washington Times Herald

QUICK MEDICATION TIP FROM ACTIVE DAILY LIVING: If you use a pill organizer, always keep one or two pills in the original bottle. It can be used to remind you what the pill is. Also, if you drop a pill on the floor, you can match it to the bottle pill, so you know what it is. If you found this quick tip helpful and would like to access more tips like this, please visit the Generations website at http://www.generationsnetwork.org and click on the Active Daily Living link on the home page. Active Daily Living offers FREE, personalized advice to enhance health, independence and aging in place. Here you can access videos, articles and resources that are tailored to your needs on a variety of topics that focus on older adults and caregivers.

GENERATIONS IS LOOKING FOR VOLUNTEERS: We welcome individuals of all ages who want to use their life experience and skills to make a difference in our community, regardless of the amount of time that they have to give. Joining does not require a fee and there are no restrictions based on education, income, age, race, experience, citizenship, gender or disability. We have over 40 active volunteer stations (based on community need) offering a wide variety of assignments in nutrition, education, health care, history, socialization, etc. Want more information? Please contact our office at (812)888-5880 or toll free at (800)742-9002. You may also reach us by e-mail at generations@vinu.edu. Come join us!

INDIANA LAUNCHES BE WELL CRISIS HELPLINE TO SUPPORT HOOSIERS DURING COVID-19 PANDEMIC AND RECOVERY: Counselors and resources now available 24/7 at Indiana 211. The Indiana Family and Social Services Administration has announced the launch of the Be Well Crisis Helpline, a confidential resource available through Indiana 211 that will allow Hoosiers to call and speak with a trained counselor 24/7. The free Be Well Crisis Helpline was established by FSSAs Division of Mental Health and Addiction in direct response to the elevated levels of stress and anxiety Hoosiers are experiencing due to the COVID-19 pandemic. Indiana 211 is a free service that connects Hoosiers with assistance and answers from thousands of health and human service resources across the state quickly, easily and confidentially. Earlier this month, Indiana 211 officially became part of FSSA, helping enable specialized programs such as the Be Well Crisis Helpline as needed. By calling 2-1-1 (and selecting 3), callers will connect with an experienced and compassionate counselor specially trained to help with issues triggered or worsened by COVID-19, said Jay Chaudhary, J.D., DMHA director. The trained counselors will be able to listen, provide support and promote personal resiliency.

The Be Well Crisis Helpline is funded by a Crisis Counseling Assistance and Training Program grant from the Federal Emergency Management Agency. In Indiana the program becomes part of the states new Be Well Indiana initiative. Additional information about the mental health resources available to Hoosiers is available at BeWellIndiana.org.

GENERATIONS MAGAZINE: Our magazine is geared toward adults in pre-retirement and retirement years and promotes active aging and preventive health. It is published three times a year and is free to subscribers. All we need is your name and address. If you would like to receive future copies of the magazine, contact Brenda Hancock at 812-888-5146 or bhancock@vinu.edu.

Generations, Area 13 Agency on Aging & Disability, is a program of Vincennes Universitys Community Services Division. Our agency connects individuals and caregivers to community resources and options for long-term care and in-home services. For more information, call 1-800-742-9002 or 812-888-5880 or visit our website at http://www.generationsnetwork.org

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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Clugston hopes to cash in on government infrastructure funds – Medicine Hat News

By MO CRANKER on July 31, 2020.

mcranker@medicinehatnews.com

With the province announcing more than $1 billion in funding for provincial municipalities earlier this week, Medicine Hats mayor is hoping to make use of the money.

The funding is a mixture of federal and provincial money and is aimed at building shovel-ready infrastructure projects starting this year. It is also there to help with municipal operating costs during the COVID-19 pandemic and to help support public transportation costs.

I think like every other municipality, well take what we can get, said Mayor Ted Clugston. We dont have the exact number yet, but were about 1.5 or 1.6 per cent of the population of Alberta. We expect to get about $8 million for capital and about $4 million for operating.

Again, we dont have the numbers yet, but those are a rough estimate of what we could be looking at in Medicine Hat.

Clugston says there are a lot of projects that could make use of the added funding.

Theres a number of capital projects that would benefit from this, he said. One I can think of is the water treatment plant upgrades.

On the operation side, weve been running transit at a loss and various other things at losses. Weve had to close down facilities like the leisure centre and the library, and theres been a lot of revenue lost in not having them open.

Were happy and were thankful for this funding.

Clugston hopes to see the money dispersed fairly.

A big concern for me is that Calgary and Edmonton havent looked after their finances as well as Medicine Hat has, he said. I dont think that would be a fair reason for them to get more than their fair share just because theyre in more trouble than we are.

I just hope Medicine Hat is able to get our per-capita amount, hopefully like everyone else does.

Clugston says the city was asked to submit a list of capital projects right at the beginning of the pandemic and that he believes funding is for projects that havent started yet.

I think the province is looking for projects that need some money to get past their tipping point, he said. The best example I have is the water treatment plant, because we need to do more with it and its very expensive.

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Clugston hopes to cash in on government infrastructure funds - Medicine Hat News

In these times, this comeback win was good medicine for the Red Sox – The Boston Globe

The Sox arrived at Citi Field having lost four consecutive games, their pitching staff in shambles. Two of those losses had come against the Mets at Fenway Park on Monday and Tuesday.

It looked like more of the same when Nate Eovaldi allowed a run in the first inning.

But Eovaldi hung in there against the imposing Jake deGrom and the Sox scored three runs in the eighth inning and held on to steal a 6-5 victory.

One game will not fix the rotation or turn the season around. But one game did prove this team is capable of fighting back and thats where it has to start.

deGrom was throwing triple-digit fastballs and vanishing changeups early in the game, running his streak of scoreless innings to 30 before Rafael Devers and Mitch Moreland had back-to-back doubles in the fourth inning to produce a run.

Moreland then made his way around on two wild pitches, not his usual way to find the plate.

After the Mets took a 3-2 lead in the sixth inning, Christian Vazquez belted a no-doubt home run in the seventh.

It only got more interesting from there. Sox manager Ron Roenicke, the proverbial good guy in a bad spot, went to Josh Osich in the bottom of the seventh. Osich was the opener on Monday and gave up a two-run homer to Michael Conforto, who was due up fourth in the inning.

When two hitters reached, it looked like a mistake. But Osich got Conforto to ground out. Heath Hembree then came in and struck out pinch hitter J.D. Davis on three pitches.

Roenicke continued to push buttons in the eighth inning. He pinch hit Kevin Pillar for Jackie Bradley Jr. against lefty Justin Wilson.

Pillar reached on a bloop single. Xander Bogaerts, who was too banged up to start, pinch hit and drew a walk. He also was too sore to run and Jonathan Arauz replaced him at first base.

(Who is that, you ask? Arauz is a 21-year-old Rule 5 pick from Houston.)

Andrew Benintendi, who to that point was 1 for 18 this season, put down a sacrifice bunt. The Mets intentionally walked J.D. Martinez to load the bases and Wilson struck out Devers.

Roenicke stuck with Moreland against a lefty and he drove in a run with a swinging bunt. When Vazquez poked a single to right, the Sox had a 6-3 lead.

Matt Barnes allowed a home run by Yoenis Cespedes leading off the bottom of the eighth inning before Robinson Cano singled. But he escaped further trouble when Jose Peraza started a double play that Arauz confidently turned with his bare hand.

Brandon Workman, in his first save situation of the season, loaded the bases with no outs. But he allowed only one run, somehow surviving a 30-pitch inning by getting Cano on a soft liner to end a game that lasted three hours and 44 minutes.

[Workman] was sweating a lot but he managed to get the job done, Vazquez said.

Roenicke acknowledged he managed the game with a sense of urgency, trying to find every advantage he could. In a 60-game season, a 1-4 start was essentially an emergency.

We need to do what we can to win some games, Roenicke said. Get that good feeling back, guys will relax and well start playing better baseball. Whatever we could do I felt we needed to do.

After a month of practicing and playing at Fenway Park, Roenicke and several of the players suggested that a new location helped. But there also was a definite sense that enough was enough after the bad homestand.

This one was big for us, Eovaldi said. Hopefully it gets the ball rolling.

Peter Abraham can be reached at peter.abraham@globe.com. Follow him on Twitter @PeteAbe.

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In these times, this comeback win was good medicine for the Red Sox - The Boston Globe

WVU Medicine hospitals earn recognition through U.S. News & World Report – Cumberland Times-News

MORGANTOWN, W.Va. Six WVU Medicine hospitals four member hospitals and two managed hospitals have been recognized in U.S. News & World Reports Best Hospitals 2020-21. This years rankings also include the WVU Medicine Urology Programs fourth consecutive national ranking and WVU Medicine J.W. Ruby Memorial Hospitals designation as theNo. 1 hospital in the state.

In addition to urology, which was ranked 40th in the country, Ruby Memorial Hospitals nephrology, neurology and neurosurgery, orthopedics and pulmonology and lung surgery programs were recognized as high performing specialties.

The six WVU Medicine hospitals designated as high performing in the procedures and conditions category are Berkeley Medical Center, Camden Clark Medical Center,Ruby Memorial,Uniontown Hospital, United Hospital Center andWheeling Hospital.

We are thrilled to have more specialties and more hospitals recognized by U.S. News and World Report. These rankings validate the strides we have made in strengthening our system and the care we provide throughout it, Albert L. Wright Jr., president and CEO of the West Virginia University Health System, said. Of course, none of this would be possible without the hard work and dedication of our employees, and we thank them for making WVU Medicine the world-class health care system that it is.

The annual Best Hospitals rankings and ratings, now in the 31st year, are designed to assist patients and their doctors in making informed decisions about where to receive care for challenging health conditions or for common elective procedures.

For the 2020-21 rankings and ratings, U.S. News evaluated more than 4,500 medical centers nationwide in 26 specialties, 10 procedures and conditions. In the 16 specialty areas, 134 hospitals were ranked in at least one specialty. In rankings by state and metro area, U.S. News recognized best regional hospitals based on high performing rankings across multiple areas of care.

For more than 30 years, U.S. News & World Report has been helping patients, along with the help of their physicians, identify the best hospitals in an array of specialties, procedures and conditions, said Ben Harder, managing editor and chief of health analysis at U.S. News. The hospitals that rise to the top of our rankings and ratings have deep medical expertise and each has built a track record of delivering good outcomes for patients.

The U.S. News Best Hospitals methodologies in most areas of care are based largely on objective measures such as risk-adjusted survival and discharge-to-home rates, volume and quality of nursing, among other care-related indicators.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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WVU Medicine hospitals earn recognition through U.S. News & World Report - Cumberland Times-News

INOVIO Receives Orphan Drug Designation From U.S. FDA for DNA Medicine INO-3107 To Treat Rare Disease Recurrent Respiratory Papillomatosis (RRP) -…

PLYMOUTH MEETING, Pennsylvania, July 29, 2020 /PRNewswire/ --INOVIO (NASDAQ: INO) today announced that the U.S. Food and Drug Administration (FDA) granted orphan drug designation for INO-3107, its DNA medicine being evaluated in a Phase 1/2 trial for treatment of recurrent respiratory papillomatosis (RRP).

RRP is a rare disease caused by human papillomavirus (HPV) types 6 and 11 infections. RRP causes noncancerous tumor growths leading to life-threatening airway obstructions and can progress to cancer in rare cases. Currently, the disease is incurable and is mostly treated by surgery to remove the tumor growths to temporarily restore the airway. The tumor almost always recurs and the surgery must be repeated, often multiple times a year. RRP can severely impact the quality of life for those living with the disease.

Orphan drug designation is intended to advance drug development for rare diseases. FDA grants orphan drug status to medicines intended for the prevention, diagnosis, and treatment of rare diseases or conditions. In the United States, an orphan disease is defined as a disease or condition with a prevalence of less than 200,000 patients in the United States annually. This orphan drug designation from the FDA qualifies INO-3107 for various development incentives, including a tax credit on expenditures incurred in clinical studies, a waiver of the New Drug Application (NDA) fee, research grant awarded by the FDA, and most importantly, 7 years of U.S. market exclusivity upon approval for the treatment of RRP.

Ami Shah Brown, Ph.D., MPH, INOVIO's Senior Vice President, Regulatory Affairs, said, "Receiving FDA's orphan drug designation for INO-3107 is an important milestone in the development of INOVIO's DNA medicine for this rare disease and clearly underscores the importance of addressing the unmet medical need for this debilitating condition."

The open-label, multicenter INO-3107 Phase 1/2 trial is currently open to enrollment to recruit 63 subjects in the U.S. and will evaluate the efficacy, safety, tolerability, and immunogenicity of INO-3107 in subjects with HPV 6 and/or 11-associated RRP who have required at least two surgical interventions per year for the past three years for the removal of associated papilloma(s). For this study, adult subjects will first undergo surgical removal of their papilloma(s) and then receive four doses of INO-3107, one every three weeks. The primary efficacy endpoint will be a doubling or more in the time between surgical interventions following the first dose of INO-3107 relative to the frequency prior to study therapy.

Last year, INOVIO published data from its pilot clinical study of INO-3106 (DNA medicine candidate targeting HPV 6-caused RRP) in the scientific journal Vaccines (MDPI). Study results demonstrated that INO-3106 generated immunogenicity and engagement and expansion of an HPV 6-specific cellular response, including cytotoxic T cells. The paper also showed that INOVIO's immunotherapy allowed two out of two patients who previously required approximately two surgeries per year for several years to manage this disease to delay the need for surgery to a robust degree; one patient was able to delay surgery for over a year and a half (584 days surgery-free) and a second remained surgery-free for over two and a half years (over 915 days surgery-free).

About RRP

Recurrent respiratory papillomatosis (RRP) is a rare disease (estimated at 15,000 active cases in the U.S.) that is characterized by the growth of tumors in the respiratory tract caused by the human papillomavirus. Although benign, papillomas can cause severe, even life-threatening airway obstruction and respiratory complications. A distinguishing aspect of this disease is the tendency for the papilloma to recur after surgical procedures to remove them. Left untreated, if RRP develops in the lungs, affected individuals can potentially experience recurrent pneumonia, chronic lung disease (bronchiectasis) and, ultimately, progressive pulmonary failure. In rare cases papillomas can become cancerous (malignant transformation) developing into squamous cell carcinoma. Additional symptoms of RRP can include hoarse voice, difficulty in sleeping and swallowing, and chronic coughing. RRP symptoms are usually more severe in children than in adults. In children, the disorder is most often diagnosed at or around the age of four years. In adults, the disorder occurs most often in the third or fourth decade.

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About INOVIO's DNA Medicines Platform

INOVIO has 15 DNA medicine clinical programs currently in development focused on HPV-associated diseases, cancer, and infectious diseases, including coronaviruses associated with MERS and COVID-19 diseases being developed under grants from the Coalition for Epidemic Preparedness Innovations (CEPI) and the U.S. Department of Defense. DNA medicines are composed of optimized DNA plasmids, which are small circles of double-stranded DNA that are synthesized or reorganized by a computer sequencing technology and designed to produce a specific immune response in the body.

INOVIO's DNA medicines deliver optimized plasmids directly into cells intramuscularly or intradermally using INOVIO's proprietary hand-held smart device called CELLECTRA. The CELLECTRA device uses a brief electrical pulse to reversibly open small pores in the cell to allow the plasmids to enter, overcoming a key limitation of other DNA and other nucleic acid approaches, such as mRNA. Once inside the cell, the DNA plasmids enable the cell to produce the targeted antigen. The antigen is processed naturally in the cell and triggers the desired T cell and antibody-mediated immune responses. Administration with the CELLECTRA device ensures that the DNA medicine is efficiently delivered directly into the body's cells, where it can go to work to drive an immune response. INOVIO's DNA medicines do not interfere with or change in any way an individual's own DNA. The advantages of INOVIO's DNA medicine platform are how fast DNA medicines can be designed and manufactured; the stability of the products, which do not require freezing in storage and transport; and the robust immune response, safety profile, and tolerability that have been demonstrated in clinical trials.

With more than 2,000 patients receiving INOVIO investigational DNA medicines in more than 7,000 applications across a range of clinical trials, INOVIO has a strong track record of rapidly generating DNA medicine candidates with potential to meet urgent global health needs.

About INOVIO

INOVIO is a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer, and diseases associated with HPV. INOVIO is the first and only company to have clinically demonstrated that a DNA medicine can be delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response. Specifically, INOVIO's lead candidate VGX-3100, currently in Phase 3 trials for precancerous cervical dysplasia, destroyed and cleared high-risk HPV 16 and 18 in a Phase 2b clinical trial. High-risk HPV is responsible for 70% of cervical cancer, 91% of anal cancer, and 69% of vulvar cancer. Also in development are programs targeting HPV-related cancers and a rare HPV-related disease, recurrent respiratory papillomatosis (RRP); non-HPV-related cancers glioblastoma multiforme (GBM) and prostate cancer; as well as externally funded infectious disease DNA vaccine development programs in Zika, Lassa fever, Ebola, HIV, and coronaviruses associated with MERS and COVID-19 diseases. Partners and collaborators include Advaccine, ApolloBio Corporation, AstraZeneca, The Bill & Melinda Gates Foundation, Coalition for Epidemic Preparedness Innovations (CEPI), Defense Advanced Research Projects Agency (DARPA)/Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND)/Department of Defense (DOD), GeneOne Life Science/VGXI, HIV Vaccines Trial Network, International Vaccine Institute (IVI), Medical CBRN Defense Consortium (MCDC), National Cancer Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Ology Bioservices, the Parker Institute for Cancer Immunotherapy, Plumbline Life Sciences, Regeneron, Richter-Helm BioLogics, Roche/Genentech, University of Pennsylvania, Walter Reed Army Institute of Research, and The Wistar Institute. INOVIO also is a proud recipient of 2020 Women on Boards "W" designation recognizing companies with more than 20% women on their board of directors. For more information, visit http://www.inovio.com.

CONTACTS:

Media: Jeff Richardson, 267-440-4211, jrichardson@inovio.comInvestors: Ben Matone, 484-362-0076, ben.matone@inovio.com

This press release contains certain forward-looking statements relating to our business, including our plans to develop DNA medicines, our expectations regarding our research and development programs, including the planned initiation and conduct of preclinical studiesand clinical trials, and the availability and timing of data from those studies and trials. Actual events or results may differ from the expectations set forth herein as a result of a number of factors, including uncertainties inherent in pre-clinical studies, clinical trials, product development programs and commercialization activities and outcomes, the availability of funding to support continuing research and studies in an effort to prove safety and efficacy of electroporation technology as a delivery mechanism or develop viable DNA medicines, our ability to support our pipeline of DNA medicine products, the ability of our collaborators to attain development and commercial milestones for products we license and product sales that will enable us to receive future payments and royalties, the adequacy of our capital resources, the availability or potential availability of alternative therapies or treatments for the conditions targeted by us or our collaborators, including alternatives that may be more efficacious or cost effective than any therapy or treatment that we and our collaborators hope to develop, issues involving product liability, issues involving patents and whether they or licenses to them will provide us with meaningful protection from others using the covered technologies, whether such proprietary rights are enforceable or defensible or infringe or allegedly infringe on rights of others or can withstand claims of invalidity and whether we can finance or devote other significant resources that may be necessary to prosecute, protect or defend them, the level of corporate expenditures, assessments of our technology by potential corporate or other partners or collaborators, capital market conditions, the impact of government healthcare proposals andother factors set forth in our Annual Report on Form 10-K for the year ended December 31, 2019, our Quarterly Report on Form 10-Q for the quarter ended June 30, 2020 and other filings we make from time to time with the Securities and Exchange Commission. There can be no assurance that any product candidate in our pipeline will be successfully developed, manufactured or commercialized, that final results of clinical trials will be supportive of regulatory approvals required to market products, or that any of the forward-looking information provided herein will be proven accurate. Forward-looking statements speak only as of the date of this release, and we undertake no obligation to update or revise these statements, except as may be required by law.

SOURCE INOVIO Pharmaceuticals, Inc.

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INOVIO Receives Orphan Drug Designation From U.S. FDA for DNA Medicine INO-3107 To Treat Rare Disease Recurrent Respiratory Papillomatosis (RRP) -...

Elon Musk selling LA homes and dreams of move to ‘self-sustaining’ Mars colony – Daily Star

Elon Musk is one of the richest people on the planet with a net worth estimated to be in the region of $69 billion.

But the tech innovator who founded PayPal, Tesla and SpaceX says hes thinking about becoming homeless.

Hes put two of his mansions up for sale, tweeting in May: I am selling almost all physical possessions. Will own no house.

He added that he would devote his life to Mars and Earth and said he didnt need any more money because possessions just weigh you down.

Now in a wide-ranging New York Times interview he said: I guess well just rent a place somewhere

I just have all these houses but nobody is using them, he said.

I use them infrequently. In the Bay Area, for example from 2002 to 2017, I never owned a house and I was there half the week so I would either sleep at the factory or in a friends spare bedroom or on a couch or in a hotel.

"I did that for 15 years.

Musk joked he could always crash with his fellow billionaires Larry Page and Sergey Brin, the founders of Google.

He says he used to enjoy sofa-surfing with his Silicon Valley pals.

He told the New York Times: It was actually, in retrospect, kind of good because you end up rotating through friends houses and you catch up with them and stay in contact, whereas these days, I have been staying in this strange Gatsby-like house, what I call the haunted mansion, and its a bit bleak, to be totally frank.

The house itself is beautiful but, you know, its like Wayne Manor without Alfred.

Musks focus is increasingly on building a self-sustaining city on Mars, which he says will require 1,000 spacecraft launches a year.

He predicts that the Mars habitat, which will be protected by a huge anti-radiation dome, will have an outdoorsy, fun atmosphere."

He told the Third Row Tesla podcast that there should be a direct democracy on Mars with the inhabitants making decisions for themselves rather than being ruled from Earth.

Musk also says there ought be simpler laws on Mars than there are on Earth.

Food for his first Mars city will be grown on solar-powered hydroponic farms, but Musk says he will probably die before the colony is completely self-sustaining but, he says, Id like to at least be around to see a bunch of ships land on Mars.

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Elon Musk selling LA homes and dreams of move to 'self-sustaining' Mars colony - Daily Star