Maryland University of Integrative Health approved for Cannabis Science program by Maryland Higher Education Commission – Reported Times

Aug 20, 2020 10:00 AM ET

iCrowd Newswire Aug 20, 2020

Laurel, Md. Maryland University of Integrative Health has been approved to offer a post-baccalaureate certificate in Cannabis Science: Therapeutics, Product Design, and Quality Assurance. This program is one of only a few graduate programs in the U.S. to focus on cannabis and to support this rapidly growing industry. The program educates students about cannabis-based products with an emphasis on health effects, safety, formulation, and quality assurance. The program addresses CBD-dominant hemp-based dietary supplements and wellness products, as well as THC-dominant medical and recreational marijuana.

MUIHs program uniquely approaches the cannabis field through the primary lenses of herbal medicine and health and wellness. It is designed for individuals who wish to promote evidence-informed, safe, and responsible use of legal high-quality cannabis-based products, especially those with a holistic approach and a focus on a health promotion model rather than a disease management model. The program is ideal for career starters and those seeking an initial career in the cannabis industry or looking to expand their job options within the field. The program is offered online and can be completed in one year.

Given the public interest in both CBD-dominant hemp products and medical marijuana, theres an increased need for a cannabis workforce and health care practitioners that understand issues of quality, safety, and appropriate use. This program is designed to meet that need, says Dr. James Snow, MUIHs Dean of Academic Affairs.

The program applies theory to practice in considering cannabis as an herb. MUIH has operated an herbal medicine dispensary since 2002. It has served as an educational setting for herbal medicine dispensary practices and quality assurance while providing herbal products to healthcare professionals, herbal medicine students, and the general public. The standards and practices from its herbal medicine dispensary, generalizable to working with a range of herbs for various health and wellness purposes in various settings, are leveraged to inform the theory and non-experiential aspects of the program and its courses.

The goal of the program is to promote safe and evidence-informed use of legal high-quality cannabis-based products while integrating both scientific and tradition-based use of herbal medicine into the therapeutic practice and product development innovations happening in this new field, says Program Director Dr. Michael Tims.

The program is grounded in MUIHs holistic and natural approach to health and wellness, and its long-standing expertise in herbal medicine. MUIH has offered masters and graduate certificate programs in herbal medicine since 2002.

About Maryland University of Integrative Health (MUIH)

Maryland University of Integrative Health (MUIH) is a leading academic institution focused on the study and practice of integrative health and wellness and one of the few universities in the U.S. dedicated solely to such practices. Deeply rooted in a holistic philosophy, its model for integrative health and wellness is grounded in whole-person, relationship-centered, evidence-informed care.

Since 1974, MUIH has been a values-driven community educating practitioners and professionals to become future health and wellness leaders through transformative programs grounded in traditional wisdom and contemporary science. MUIH has more than 20 progressive graduate degree programs in a wide range of disciplines, offered on-campus and online. In the on-campus Natural Care Center and community outreach settings, MUIH provides compassionate and affordable healthcare from student interns and professional practitioners, which delivers more than 20,000 clinical treatments and consultations each year. For more information visit http://www.muih.edu.

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Keywords:Cannabis, Cannabis Science, Integrative Health, Certification, Healthcare, Online Programs

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Maryland University of Integrative Health approved for Cannabis Science program by Maryland Higher Education Commission - Reported Times

UCI Health-Newport Beach center offers science-based integrative health – UCI News

Irvine, Calif., Aug. 18, 2020 UCI Health is pleased to announce the opening of its latest Newport Beach location, which is dedicated to preventing disease and managing health by considering all aspects of a patients mind, body and spirit. UCI Health-Newport Beach is the first to offer a comprehensive model of science-based medicine combined with a philosophy of care that makes use of all therapies and disciplines to achieve optimal health and healing.

At UCI Health, we make a daily commitment to stop at nothing to meet and exceed the expectations of every member of our community, said Chad T. Lefteris, CEO of UCI Health. Our multidisciplinary clinical care teams provide world-class primary and specialty care driven by the discovery and innovation of Orange Countys only university health system.

UCI Health is built to advance knowledge that improves patient health and wellness, Lefteris said.

Advances in medicine are made every day. Community-based health providers treat patients within the standards of care, while academic health systems like UCI Health conduct the research that improves these standards. For example, UCI Health integrative health faculty physicians publish research into the effect of diet, mood and stress on specific conditions that they then translate into cutting-edge patient care.

UCI Health-Newport Beach is located at 2161 San Joaquin Hills Road, Newport Beach, on the corner of San Joaquin Hills Road and Avocado Avenue.

We take a balanced approach to wellness, said Shaista Malik, MD, PhD, associate vice chancellor for integrative health at the Susan and Henry Samueli College of Health Sciences. Integrative health means that when we care for you, we take into account every aspect of your life your health history, lifestyle, stressors and other factors to restore your well-being and quality of life.

This whole-person approach allows UCI Health caregivers to understand each patients unique circumstances and determine the most appropriate treatments and therapies, Malik said.

Our providers work together to develop treatment plans that adapt to your specific needs, to help you live a healthy and balanced life, she added.

Services available at UCI Health-Newport Beach include:

For more information or to make an appointment, visit ucihealth.org/newportbeach or call 949-386-5700.

UCI Health comprises the clinical enterprise of the University of California, Irvine. Patients can access UCI Health at primary and specialty care offices across Orange County and at its main campus, UCI Medical Center in Orange, California. The 418-bed acute care hospital provides tertiary and quaternary care, ambulatory and specialty medical clinics, and behavioral health and rehabilitation services. U.S. News & World Report has recognized UCI Medical Center among Americas Best Hospitals for 20 consecutive years. The enterprise is home to Orange Countys only National Cancer Institute-designated comprehensive cancer center, high-risk perinatal/neonatal program and American College of Surgeons-verified Level I adult and Level II pediatric trauma center and regional burn center. It is the primary teaching hospital for the UCI School of Medicine. UCI Health serves a region of nearly 4 million people in Orange County, western Riverside County and southeast Los Angeles County. Follow us on Facebook and Twitter.

About the University of California, Irvine:Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 30,000 students and offers 192 degree programs. Its located in one of the worlds safest and most economically vibrant communities and is Orange Countys second-largest employer, contributing $5 billion annually to the local economy. For more on UCI, visitwww.uci.edu.

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UCI Health-Newport Beach center offers science-based integrative health - UCI News

Whole Grain Labels Confuse People Trying to Pick Healthy Options – Healthline

Whole grains may be better for your health, but figuring out which products are healthier by relying on whole grain labels can actually make it difficult to make healthy choices.

A new study found that these labels on cereal, bread, and crackers can be confusing for people trying to make smarter food choices.

The report published in the journal Public Health Nutrition detailed a survey of 1,030 U.S. adults. The participants were shown photos of real and hypothetical products with food labels. They were asked to identify healthier options for the hypothetical products or assess the whole grain content of the real products.

A significant number of respondents had the wrong answer for which product was healthier.

Our study results show that many consumers cannot correctly identify the amount of whole grains or select a healthier whole grain product, Parke Wilde, PhD, study author and professor at the Tufts University, said in a statement.

The authors wanted to find out if there was a strong legal argument that whole grain labels are misleading. Evidence could back up a movement for increased labeling requirements.

I would say when it comes to deceptive labels, whole grain claims are among the worst, added co-author Jennifer L. Pomeranz, an assistant professor of public health policy and management at New York University in New York City.

The labeling of whole grains has been a source of confusion and deception for a long time, said Dr. Amy Burkhart, an integrative medicine physician and registered dietitian based in Napa, California. Many brands use the term whole grain and others to influence customers purchasing decisions by creating a healthy product facade.

The term whole grain means that all portions of the kernel are included in the product, Burkhart explained.

The blurring of lines begins here, she said. The product only has to contain 51 percent whole grain ingredients to use the term whole grains.

For example, a label can say whole grain but up to 49 percent of the product may include processed grains.

There are whole grains and refined grains, said Vicki Shanta Retelny, RDN, a consultant for Northwestern Memorial Hospital in Chicago. Whole grains contain three parts: the bran, germ, and endosperm layers. Refined grains have been stripped of the bran and the germ layers and, in turn, are devoid of fiber, iron, B-vitamins, fatty acids, and antioxidants, which are inherent in the whole intact grain.

Refined grains are white flour products that may be enriched or fortified with vitamins and minerals to provide nutritional value.

Whole grains that are wheat-based contain gluten. Wheat-free grains are typically gluten-free unless there is cross-contamination during processing of the grain, Retelny said.

According to the U.S. Department of Health and Human Services and the U.S. Department of Agricultures 2015-2020 Dietary Guidelines for Americans, half of all grains consumed should be whole grains. Getting enough whole grains has been linked with lower risk of heart disease, type 2 diabetes, and cancer.

The most common types of whole grains that contain gluten include wheat, barley, rye, and spelt. Gluten-free whole grains include corn, oats, brown rice, quinoa, buckwheat, brown rice, sorghum, teff, millet, and amaranth, Burkhart said.

Ancient grains such as farro and spelt are those that have not been changed by modern breeding methods over the last several hundred years. Nonwheat ancient whole grains include sorghum, quinoa, and millet, she noted.

This doesnt mean they are necessarily more nutritious but they do require a lower amount of pesticides and water to be grown which is beneficial to the planet, Burkhart said.

As part of the survey, the packages on the hypothetical products either had no front-of-package whole grain label or were marked with multigrain, made with whole grains, or a whole grain stamp. The packages on the real products displayed the actual product markings, including multigrain, honey wheat, and 12 grain.

When looking at the hypothetical products, people had to answer if they thought the product was healthier. For the real products, they were asked to assess the whole grain content.

Of the hypothetical products, 29 percent to 47 percent incorrectly identified the healthier item. Specifically, they had the wrong answer 31 percent of the time for cereal, up to 37 percent for crackers, and 47 percent for bread items.

Of the real products that were not mostly composed of whole grains, 43 to 51 percent of respondents overstated the whole grain content depending on the products.

Researchers found 41 percent overstated the grain content for multigrain crackers, 43 percent for honey wheat bread, and 51 percent for 12-grain bread.

However, respondents more accurately identified the whole grain content of an oat cereal that mostly included whole grain.

While experts find the labeling standards by the Food and Drug Administration confusing, other groups have pushed for more transparency.

The Whole Grains Council, a nonprofit consumer advocacy group, has created three stamps to guide consumers but they are not on all products.

Companies must apply to use the stamp. The 100 percent stamp includes products where all grains are whole grain and the product contains at least 16 grams of whole grain per serving. The 50 percent stamp means that 50 percent or more of the grains in the product are whole and the product contains at least 8g of whole grain per serving. The basic stamp means the item contains at least 8 grams of whole grain per serving, Burkhart explained.

Terms such as wheat, semolina, durum wheat, organic flour, stoneground, multigrain, fiber, and cracked wheat may or may not be whole grains.

When youre buying a whole grain product, such as bread or crackers, look for the first ingredient to be a whole grain ingredient such as whole grain flour or whole wheat flour, said Amy Gorin, MS, a registered dietitian nutritionist in New Jersey. Many whole grain products are made with whole grains but dont contain them as a primary ingredient.

On bread labels, for example, the first ingredient should be whole grain flour, whole wheat flour, or another whole grain ingredient. It should not, for example, be enriched wheat flour.

The fiber content on the nutrition label is another giveaway whole grain products are likely to be good or excellent sources of fiber, Gorin said.

Retelny advises her clients to focus on the ingredients list of a product for the word whole before the grain. For example, look for whole wheat or whole oats instead of enriched wheat or oats, because those are refined versions of the grain, she said.

Just because its a brown bread doesnt mean its whole grain, Gorin said.

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Whole Grain Labels Confuse People Trying to Pick Healthy Options - Healthline

Reimagine Well and Kids Kicking Cancer Partner on Innovative Platform for Patients and Families – PRNewswire

LAGUNA BEACH, Calif., Aug. 18, 2020 /PRNewswire/ -- "Through an evidence-based innovative program that merges modern integrative medicine with traditional martial arts, Kids Kicking Cancer addresses the overwhelming needs of children with illness," said Rabbi Elimelech Goldberg, founder and global director for Kids Kicking Cancer. He adds, "We offer one-on-one training and group classes for both pediatric inpatients and outpatients in over fifty hospitals and institutions around the globe."

"We are thrilled to help this extraordinary organization expand their programs as broadly as possible," states Roger Holzberg, co-founder of Reimagine Well.

Together the two organizations are partnering to launch the Kids Kicking Cancer Infusionarium Platform, available to any pediatric hospital that would like to have the educational programs, immersive healing experiences, and live events as a part of what they offer to their patients and families as they undergo treatment. If your hospital would like access to the platform; contact us and we will find a way to make it available to you.

A patient and family version of the program is also available 24/7, to provide support whenever and wherever it's needed, over the course of the entire patient journey. Patients and families are able to use it on their smartphones, tablets, or home computers. If you, or someone you care about, would benefit from the Kids Kicking Cancer patient and family platform - click hereto get started.

All services provided by Kids Kicking Cancer are at no cost to the children and their families.

About Reimagine WellReimagine Well provides a proprietary platform and programs designed for infusion therapy, assisted living, and more; and has compiled an extensive library of patient-directed immersive healing experiences and disease-specific 'Learn Guides' hosted by clinicians and medical experts. Roger Holzberg and Leonard Sender, MD, founded Reimagine Well. Sender is the Medical Director of the Hyundai Cancer Institute at CHOC Children's Hospital, Orange County, California. He is board certified in Pediatric Hematology/Oncology and his primary interest is in immuno-oncology. Holzberg is the founder of My Bridge 4 Life, a former award-winning Disney Imagineer, the first (consulting) Creative Director of the National Cancer Institute and a 15-year cancer survivor.

About Kids Kicking Cancer Kids Kicking Cancer's mission is to ease the pain of very sick children while empowering them to heal physically, spiritually and emotionally.Kids Kicking Cancer provides services in 92 facilities in 7 countries. Their vision is to lower the pain of one million children by 2025. All services provided by Kids Kicking Cancer are at no cost to the children and their families. Children 3 years & older, and their siblings, are eligible for the program.

Contacts: Pam Carstens / (949) 793-8777 / [emailprotected]Cindy Cohen, MS, CCLS / (248) 864-8238 / [emailprotected]

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Reimagine Well and Kids Kicking Cancer Partner on Innovative Platform for Patients and Families - PRNewswire

Is The Placebo Effect Actually Real? – The Boca Raton Tribune

Millions of people who suffer from injuries or illness have heard about the placebo effect, but many of them continue to doubt its efficacy, arguing that it sounds far too good to be true. There are actually compelling reasons to believe that the placebo effect does indeed produce tremendous results in some patients, yet many doubters persist in asserting that its pseudoscience with no facts to back it. In reality, harnessing the power of the mind to achieve medical results is indeed possible, as using placebo effects elsehwere like in the business world can also be a roaring success.

Heres what you need to know about the placebo effect, and why you should be convinced of its effectiveness.

Medical experts agree on its efficacy

According to the National Center for Complementary and Integrative Health, part of the U.S. Department of Health and Human Services, the placebo effect is best described as a beneficial health outcome resulting from a persons anticipation that an intervention will help. In other words, you can trick your mind into thinking that your body is being helped by a forthcoming treatment option, even if its an inert substance that doesnt actually deliver anything special to your body. Mind over matter, as the saying goes, is evidently true in many instances.

Demonstrable health benefits and cognitive changes to how your brain functions may seem impossible to achieve with inert substances that dont actually possess any medicine, but medical experts have discovered that this tactic works time and time again. Research has even illustrated that so-called open placebos, or placebo treatments where people are made aware of the fact that its a placebo before consuming it, can produce positive results in patients. Modern medical technology is astounding its easier to get a cheap MRI with the help of a personal injury lawyer or a test for various genetic illnesses these days than ever before but sometimes all that it takes is a placebo to deliver results.

As the Harvard Mens Health Watch points out, your mind is an incredibly powerful healing tool if you give it the opportunity to help mend your body. They cant deliver miraculous results, of course, so theres no ending cancer or solving a brain tumor with the help of a placebo, but for mild conditions in many patients they can seriously help deliver relief to those who are otherwise bereft of comfort.

Various things can boost the placebo effect good branding that leads consumers to think that the medicine theyre consuming is more potent than it actually is can lead to positive medical results, for instance. The color of the pill in question could change how people perceive it in their minds. In some instances, taking more placebo pills at once can yield greater results than only taking a few of them. You should always contact a medical professional before ingesting any substance youre unfamiliar with, however, and refuse placebo treatments from those who lack valid medical certifications. Even placebo surgeries have been shown to have some effect, proving just how bright a future the field of placebo treatments is facing.

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Is The Placebo Effect Actually Real? - The Boca Raton Tribune

Acupuncture shown to regulate inflammation in mice – BioWorld Online

A Sino-U.S. collaborative study has demonstrated that acupuncture regulates inflammation by activating pro- or anti-inflammatory signaling pathways, while mitigating cytokine storms in mice with systemic inflammation, the study authors reported in the Aug. 12, 2020, edition of Neuron.

The study also found that the acupuncture site, intensity and timing determined how it affected response, which has important implications for acupuncture use in inflammatory diseases and as adjunctive cancer therapy.

Acupuncture was further shown to influence how mice coped with the aberrant immune system reaction of cytokine storm due to rapid excessive release of pro-inflammatory cytokines.

Our study provides an insight into how acupuncture can drive distinct autonomic pathways and modulate inflammation in acupoint-, stimulation intensity- and disease state-dependent manners, said study leader Qiufu Ma, a professor in the Dana Farber Cancer Institute and the Department of Neurobiology at Harvard Medical School.

Cytokine storms are a characteristic of inflammatory diseases, notably bacterial or viral infections causing sepsis, an organ-damaging, often-fatal inflammatory response.

Cytokine storms can also be caused by excessive inflammatory responses to traumatic tissue injury, some surgeries, and cancer immunotherapies such as immune checkpoint inhibition, but currently there are no FDA-approved treatments for severe cytokine storms, noted Ma.

For cancer patients receiving immunotherapy who develop inflammatory side effects, milder symptoms might be relieved by corticosteroids, which have their own side effects, he said.

In COVID-19 patients, early pilot studies have suggested using an antibody against the cytokine, interleukin-6 (IL-6), but larger clinical trials are needed to confirm the efficacy and safety of this approach, he told BioWorld.

A traditional Chinese medicine technique, acupuncture has become increasingly integrated into Western medicine, particularly for treating chronic pain and gastrointestinal disorders.

It involves mechanical stimulation of acupoints, supposedly triggering nerve signaling and affecting the function of internal organs corresponding to those acupoints, but acupunctures basic underlying mechanisms have not been fully elucidated.

In their new study, Ma and his research team investigated the use of electroacupuncture stimulation (ES), in which ultra-thin electrodes offer better control of stimulation intensity than traditional needles.

The researchers investigated two cell types secreting the neurotransmitters known to be important inflammatory mediators: adrenal gland chromaffin cells, the main producers of adrenaline, noradrenaline (NA) and dopamine, and peripheral NA neurons.

To determine the precise role these cells play in inflammatory responses, the researchers used a novel genetic tool to ablate chromaffin cells or NA neurons.

We genetically introduced the human diphtheria toxin receptor (DTR) selectively to molecularly defined sympathetic cells, such as those marked by expression of neuropeptide Y (NPY), explained Ma.

Injecting a modified diphtheria toxin that does not cross the brain-blood barrier can selectively ablate DTR-expressing cells, creating mice lacking both NPY-expressing chromaffin cells and NA neurons, or those with a more selective ablation of NPY-expressing chromaffin cells via injecting low-dose toxin only into the adrenal gland.

That allowed inflammatory response comparison in mice with and without those cells, to determine their role in modulating inflammation. The markedly different responses then identified those cells as key regulators of inflammation.

Hind-limb administration of low-intensity ES to mice with a bacterial toxin-induced cytokine storm was shown to activate the vagus-adrenal axis, inducing dopamine secretion from chromaffin cells.

We used the induction of a neuronal activation marker to show that low-intensity ES activated hind-brain vagal efferent neurons, which are known to innervate thoracic and visceral organs and tissues, said Ma.

We then showed that low-intensity ES could reduce cytokine storms and promote survival, and that these ES effects were lost in mice with transected vagal efferents or in those with ablation of NPY-expressing adrenal chromaffin cells, suggesting involvement of the vagal-adrenal anti-inflammatory axis.

Specifically, treated animals had more than 50% reductions in the cytokines, tumor necrosis factor-alpha (TNF-a), IL-6 and IL-1b, than untreated controls, and prolonged survival rates of 60% vs. 20%, respectively.

In addition, the vagus-adrenal axis was shown to be activated by hind-limb ES, but not by that using abdominal acupoints, demonstrating the importance of acupoint selectivity in driving specific anti-inflammatory pathways.

Treatment timing was also found to be critical, with high-intensity abdominal stimulation producing markedly different outcomes, depending on when treatment occurred.

For example, animals treated before developing cytokine storm had lower levels of inflammation during subsequent disease and their survival increased from a range of 20% to 30% to a range of 70% to 80%.

Conversely, those treated after disease onset and during the cytokine storm peak experienced worse inflammation and more severe disease.

Together, those findings suggest that ES could be a versatile treatment modality, from adjunct therapy for sepsis to targeted treatment of site-specific inflammation, such as in inflammatory intestinal diseases.

Acupuncture might also help modulate inflammation due to cancer immune therapy, which can trigger cytokine storms, and is currently used in integrative cancer treatment to help patients tolerate treatment side effects.

However, before considering any therapeutic use, those findings must be further confirmed in animals and humans, optimal ES parameters must be defined and its safety established.

Safety

High-intensity ES can drive spinal-splenic noradrenergic sympathetic neuronal pathway, potently reducing inflammation if performed before cytokine storm induction, said Ma.

However, after the first cytokine storm wave has peaked, high-intensity ES can exacerbate inflammation and increase fatality rates, due to altered NA receptor profiles in immune cells switching from anti-inflammatory to pro-inflammatory dominance.

As such, high intensity ES may be associated with unforeseen safety issues, but fortunately low intensity ES is sufficient to drive the vagal-adrenal axis and safely attenuate inflammation in a disease state-independent manner, Ma said.

In the future, he said, inflammation modulation needs to be fine-tuned, since excessive suppression could reduce the ability of the immune system to fight with infection, necessitating future human studies to optimize stimulation parameters.

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newsGP – Managing post-acute issues in COVID patients: What GPs need to know – RACGP

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UPDATED: Even people who experienced mild infection may have long-term symptoms.

UPDATED

Once the most severe phase of COVID-19 infection has passed, many patients experience long-term issues.These patients often describe themselves as long-haulers or as having long-COVID.As the number of Australians diagnosed with COVID-19 has grown, so too has the number of patients with post-acute issues.This has led many GPs to seek information on how to best manage these ongoing concerns. Melbourne-based GP Associate Professor Vicki Kotsirilos, founding Chair of the RACGP Specific Interests Integrative Medicine network, is one of them.I actually thought about that last week when I read an article about long-term effects [of COVID-19], she told newsGP.I thought, Okay, what will I be advising my patients?Associate Professor Kotsirilos says it is totally understandable that robust clinical guidelines are not yet in place to help GPs manage patients with long-term sequelae of COVID-19.COVID-19 is a new disease and it takes a while for health authorities to prepare clinical, treatment and even practice guidelines, she said.I dont think weve been slow to provide that information. In fact, if anything, I think the RACGP and health authorities have been excellent.That said, Associate Professor Kotsirilos says it is imperative GPs are provided with more detailed information when it comes to specific clinical guidelines on helping manage potential long-term effects, such as the hypercoagulable state seen in some patients.We clearly do need better and quicker clinical guidelines for us to access, she said.It is important for GPs to know the best evidence-based treatments in those situations from a long-term perspective.A new article, published in The BMJ on 11 August, explores management of post-acute issues in COVID-19 patients; though the authors acknowledge there are not yet definitive, evidence-based recommendations for management.We therefore used a pragmatic approach based on published studies on SARS and MERS, early editorials and consensus based guidance on COVID-19, a living systematic review, early reports of telerehabilitation (support and exercise via video link), and our own clinical experience, they wrote.According to the article, which is directed at primary care practitioners, approximately 10% of people remain unwell beyond three weeks after diagnosis with COVID-19.Post-acute COVID-19 long COVID seems to be a multi-system disease, sometimes occurring after a relatively mild acute illness, the authors wrote.They say such patients can broadly be divided into those who may have serious sequelae, such as thromboembolic complications, and those with a non-specific clinical picture, mainly characterised by symptoms such as fatigue and breathlessness.The authors define long-COVID as extending beyond three weeks from the onset of first symptoms, while chronic-COVID is defined as extending beyond 12 weeks.The authors list the symptoms of post-acute COVID-19 as:

On the other hand, severe breathlessness may require urgent referral. The following management principles apply:

Associate Professor Vicki Kotsirilos says clinical guidelines are needed to help GPs manage patients with post-acute symptoms of this infection.

FatigueFatigue is a common complaint following infection with COVID-19.It has also been called the most common and debilitating symptom in [ICU] survivors.A letter to the editor published in Medical Hypotheses on 27 June highlights the potential for a post-viral syndrome to manifest following COVID-19.After the acute SARS episode some patients, many of whom were healthcare workers, went on to develop a chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)-like illness, which nearly 20months on prevented them returning to work, the authors of the letter wrote.We propose that once an acute COVID-19 infection has been overcome, a subgroup of remitted patients are likely to experience long-term adverse effects resembling CFS/ME symptomatology such as persistent fatigue, diffuse myalgia, depressive symptoms, and non-restorative sleep.The authors of the BMJ article say they found no published evidence on the efficacy of either pharmacological or non-pharmacological interventions on fatigue after COVID-19.

They also say there is much debate and controversy about the role of graded exercise in chronic fatigue generally, and in COVID-19 in particular, referencing a recent statement from National Institute for Health and Care Excellence (NICE).Pending direct evidence from research studies, we suggest that exercise in such patients should be undertaken cautiously and cut back if the patient develops fever, breathlessness, severe fatigue, or muscle aches, the authors wrote.Understanding, support, and reassurance from the primary care clinician are a crucial component of management.Associate Professor Kotsirilos says she would advise patients experiencing fatigue to address lifestyle and behavioural factors.Ensuring that they eat well, that they rest, theyre cared for by other people, go to bed early for a good nights sleep and a graded exercise program, she said. It would be just like [management strategies for] patients suffering post-viral fatigue.Chest painThis is another common symptom after acute COVID-19, and clinical assessment should follow similar principles to that for any chest pain.Where the diagnosis is uncertain, or the patient is acutely unwell, urgent cardiology referral may be needed for specialist assessment and investigations (including echocardiography, computed tomography of the chest, or cardiac magnetic resonance imaging), the BMJ authors wrote.Ventricular dysfunctionThe authors advise intense cardiovascular exercise must be avoided for three months in all patients after myocarditis or pericarditis.Meanwhile, athletes are advised to take 36 months of complete rest from cardiovascular training followed by specialist follow-up.ThromboembolismIt is now recognised that COVID-19 can cause a hypercoagulable state with increased risk of thromboembolic events.The authors say many hospitalised patients receive prophylactic anticoagulation.Recommendations for anticoagulation after discharge vary, but higher risk patients are typically discharged from hospital with 10 days of extended thromboprophylaxis, they wrote.If the patient has been diagnosed with a thrombotic episode, anticoagulation and further investigation and monitoring should follow standard guidelines.It is not known how long patients remain hypercoagulable following acute COVID-19.Associate Professor Kotsirilos would like further detailed information for GPs on this topic, including whether the best anticoagulant in this situation is warfarin or another blood thinner, such as low-dose aspirin.That is important for GPs to know, she said.Clinical guidelines are required to help us keep up-to-date with evidence-based appropriate treatments such as the role of blood thinners when to prescribe them and for how long.Neurological sequelaePatients with serious complications such as stroke, seizures or encephalitis should be referred to a neurologist.Meanwhile, non-specific symptoms such as headaches, dizziness and brain fog require supportive management and symptom monitoring.Brain fog is a particularly common symptom reported by patients who describe themselves as long-haulers.Associate Professor Kotsirilos says measures that can help a patient manage fatigue are also applicable for brain fog.Brain fog has been seen with other post-viral chronic fatigue syndromes, she said.With brain fog, its all about resting, avoiding the computer, letting the head or brain rest, not returning to work too quickly, exercise especially outdoors for fresh air but gradually.Other measures include ensuring adequate sleep, reducing stress and eating well.Mental healthWhile a minority of patients may benefit from referral to mental health services, it is important not to pathologise the majority, the authors wrote.Patient organisations emphasise wellbeing, mindfulness, social connection, self-care (including diet and hydration), peer support, and symptom control.Associate Professor Kotsirilos agrees these measures can assist with mental health issues. However, she says regular check-ins with a GP and a mental health care plan may also be important if patients are not coping.Holistic management of the patientAssociate Professor Kotsirilos believes GPs are ideally placed to help manage COVID-19 patients with post-acute issues.When patients have suffered from COVID-19 infection and are suffering long-term effects like chronic fatigue, GPs are in a great position to validate their symptoms, reassure them, explain to them that it is a new disease, were only just coming to understand it, but it is common to get post-viral fatigue, brain fog and other symptoms, she said.GPs play an important role in helping patients make a full recovery post COVID-19 infection.She says GPs can also use this opportunity to discuss lifestyle measures, exercise, reducing stress and avoiding harmful substances like excessive alcohol and smoking.The BMJ authors agree primary care practitioners are in an ideal position to ensure ongoing patient care for those with post-acute symptoms of COVID-19.From the limited current evidence, we anticipate that many patients whose COVID-19 illness is prolonged will recover without specialist input through a holistic and paced approach, they wrote.GPs can also offer their patients much-needed reassurance throughout this process.Patients, many of whom were young and fit before their illness, have described being dismissed or treated as hypochondriacs by health professionals, the authors wrote.In these uncertain times, one key role that the primary care practitioner can play is that of witness, honouring the story of the patient whose protracted recovery was unexpected, alarming, and does not make sense.Log in below to join the conversation.

The RACGP Awards recognise outstanding achievements and exceptional individuals for their contribution to general practice. Visit theRACGP websitefor more information, or to nominate a GP or GP in training.

coronavirus COVID-19 long-COVID

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newsGP - Managing post-acute issues in COVID patients: What GPs need to know - RACGP

Johnson & Johnson Celebrates Role of Scientists In Society with 2020 Dr. Paul Janssen Award for Biomedical Research, Part of the Champions of…

NEW BRUNSWICK, N.J., Aug. 20, 2020 /PRNewswire/ --Johnson & Johnson(NYSE: JNJ) today announced Lewis Cantley, Ph.D., of Weill Cornell Medicine and NewYork-Presbyterian as the winner of the 2020 Dr. Paul Janssen Award for Biomedical Research for his incisive research revealing the fundamental aspects of metabolism that have profound implications for the understanding, diagnosis and treatment of human diseases such as cancer and diabetes.

"Like all of the past Dr. Paul Janssen Award winners, and indeed like Dr. Janssen himself, Dr. Cantley challenged the status quo, asked provocative questions, and tirelessly followed his curiosity to uncover scientific insights that have led to an expanded understanding of human biology and the development of solutions that can improve people's lives," said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson. "We are proud to honor the legacy of Dr. Janssen by celebrating today's research pioneers like Dr. Cantley."

Selected by an independent committee of world-renowned scientists, Cantley won for his discovery of phosphoinositide 3 kinase (PI3K), a key enzyme that promotes cell growth and division, and plays a critical role in diseases including cancer to diabetes, as well as rare diseases such as mosaicism. Hejoins 18 scientistswho have received the Dr. Paul Janssen Award since 2004, including threewho went on to win the Nobel Prize.

"I am honored to be named the winner of this year's Paul Janssen Award," said Dr. Cantley, the Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center and a professor of cancer biology at Weill Cornell Medicine. "I share Dr. Janssen's passion for scientific exploration, and I'm pleased to receive this recognition of the work done in my laboratory."

The Award is part of Johnson & Johnson's Champions of Science initiative to fuel public engagement, support and trust in science.

"The critical role of science in our society has been brought to the forefront by the COVID-19 pandemic," says Seema Kumar, Vice President, Innovation, Global Health and Science Policy Communication, Johnson & Johnson. "Today more than ever, we look to science to provide answers and new solutions to maintain our health and solve complex medical challenges. By sharing the stories of scientists across generations and geographies, from students to those at the pinnacle of their career, like the winners of the Dr. Paul Janssen Award, we hope to engage more people in becoming ardent champions of science."

Dr. Cantley's work will be celebrated during the Champions of Science: Dr. Paul Janssen Award 2020 webcast, open to the public, on Wednesday, September 16, 2020, at 12:30 p.m. ET via Johnson & Johnson's page on LinkedIn. This unique virtual celebration will honor Dr. Cantley, showcase young innovators at the start of their STEM journeys, and engage the public in a conversation about the importance of science in society.

In addition, Dr. Cantley will be honored at a virtual scientific symposium, presented in collaboration with the New York Academy of Sciences, on September 16, 2020, at 9 a.m. ET. The event will feature presentations from leading experts on the biology of cellular metabolism and its role in human health and disease, including Matthew Vander Heiden, M.D., Ph.D. of the Koch Institute for Integrative Cancer Research atMIT, Karen Vousden, Ph.D., of the Francis Crick Institute, and Ulrike Philippar, Ph.D., of Janssen Pharmaceuticals. Click here to register or for additional information.

"Dr. Cantley's discoveries have transformed our understanding of how human cellular metabolism works," said Richard P. Lifton, M.D., Ph.D., President of The Rockefeller University and Dr. Paul Janssen Award committee chair. "The discovery of PI3K has led to better treatment of a range of diseases, bringing hope to countless patients around the world."

"The research of Dr. Cantley has been illustrative in understanding the metabolic properties of malignant cells and in informing more targeted approaches in cancer treatment," said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. "Dr. Cantley's contributions have spurred innovations in oncology that have ultimately benefited many patients, and he has inspired many scientists to progress new research strategies."

About Champions of Science Science touches our lives in every imaginable way. From antibiotics and telecommunications, to genomics, precision medicine and 3D printing, science has improved the human condition leading to longer, healthier, happier lives for people all over the world. To continue to advance, science needs champions! As a global healthcare company, The Johnson & Johnson Family of Companies is uniquely positioned to champion the role of science in society. Champions of Science is a multi-faceted public engagement initiative to convene and catalyze champions of science and engage people of all generations and backgrounds to see the unlimited opportunities that science brings. To learn more, visit http://www.jnj.com/champions-of-science

About the Dr. Paul Janssen Award for Biomedical Research Dr. Paul Janssen was one of the 20th century's most gifted and passionate researchers. He helped save millions of lives through his contribution to the discovery and development of more than 80 medicines, four of which remain on the World Health Organization's list of essential medicines.

The Dr. Paul Janssen Award for Biomedical Research was established by Johnson & Johnson in 2004 to honor the memory of Dr. Paul. Since its inception, the Award has recognized 18 outstanding scientists, three of whom have gone on to win the Nobel Prize for the same work. Winners are chosen by an independent selection committee of the world's most renowned scientists. The Award, which includes a $200,000 prize, is presented at ceremonies in September.

Previous winners include:

Learn more about The Dr. Paul Janssen Award at http://www.pauljanssenaward.com

About Johnson & Johnson At Johnson & Johnson, we believe good health is the foundation of vibrant lives, thriving communities and forward progress. That's why for more than 130 years, we have aimed to keep people well at every age and every stage of life. Today, as the world's largest and most broadly based health care company, we are committed to using our reach and size for good. We strive to improve access and affordability, create healthier communities, and put a healthy mind, body and environment within reach of everyone, everywhere. We are blending our heart, science and ingenuity to profoundly change the trajectory of health for humanity. To learn more, visit http://www.jnj.com

SOURCE Johnson & Johnson

http://www.jnj.com

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Johnson & Johnson Celebrates Role of Scientists In Society with 2020 Dr. Paul Janssen Award for Biomedical Research, Part of the Champions of...

Bushu plans $100 million expansion for pharmaceutical inspection facility; RUCDR breaks away from Rutgers University, relaunches as IBX – Endpoints…

In an effort to become an Asia hub for pharmaceutical inspection and distribution, contract manufacturer Bushu Pharmaceuticals is pouring $100 million into the expansion of its Misato, Japan plant over the next 5 years.

Bushu is nearly done building its 42,000-square-foot cold chain warehouse in Misato. Upgrades include 8 new packaging lines, new inspection stations, and IT improvements to its production automation and laboratory information management systems. When construction is complete, the company will have 12 inspection stations for pre-filled syringes, and 7 stations each for liquid vials and lyophilized vials. In total, 23 stations will be supported by cameras.

We are excited about our capital expansion plans, Bushu COO Tadao Takano said in a prepared statement. Our Asia hub strategy is coming to life. The added space and additional inspection lines will allow us to bring more of our clients bulk products into the country, which will make their logistics and supply chain systems much more efficient. Nicole DeFeudis

RUCDR Infinite Biologics broke away from Rutgers University on Wednesday, and relaunched as Infinity BiologiX (IBX). The company will still conduct regenerative medicine and oncology research at the Rutgers campus but its now financially independent.

Rutgers University approved the sale of RUCDR in June. Andrew Brooks, an adjunct professor at Rutgers and former RUCDR COO, will remain at the helm as IBX CEO and CSO. RUCDR alums Robin Grimwood and Russell Hager will serve as president and COO, and executive VP of strategic operations, respectively. Viking Global Investors contributed a significant infusion of growth capital, according to the company.

In May, RUCDR became the first to get a EUA for a saliva-based Covid-19 test a method that Brooks touted as quicker and more scalable than nasal swabbing. The company has since developed an at-home saliva-based test with partners Spectrum Solutions and Accurate Diagnostic Labs.

The transition to IBX enables us to scale and innovate at a pace which will increase our footprint both here in the U.S. and abroad. RUCDR has made a profound impact in academia and industry in the areas of genomics, biological sciences, and medicine. We now look forward to the immense opportunity ahead as an organization independent from Rutgers while maintaining our core academic drive and mission, Grimwood said in a prepared statement. Nicole DeFeudis

Rakuten Medical, a biotech focusing on a form of cancer therapy known as photoimmunotherapy, has acquired a company that produces and commercializes a large range of catheters.

The biotech announced the acquisition of Medlight SA on Wednesday morning, emphasizing the need to ensure access to a supply chain vital to the development of diagnostics and therapeutic light technologies. Financial terms of the deal were not disclosed.

Wednesdays deal also brings Medlights network of subcontractors for optical devices on board and gives Rakuten more comprehensive oversight of its developmental supply chain.

Rakutens lead program is dubbed ASP-1929, which received fast track designation from the FDA. The candidate is an antibody-drug conjugate comprised of the antibody cetuximab, which binds to epidermal growth factor receptors, and a dye that locally activates the antibody through a non-thermal red light emitted via laser. ASP-1929 is currently in Phase III for the treatment of recurring head and neck cancers. Max Gelman

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Everything You Need To Know About Cyberpunk 2077s Anime, Edgerunners – Fiction Talk

During the first of many planned live stream updates for the upcoming game Cyberpunk 2077 (dubbed as Night City Wire Episodes), CD Projekt Red announced a partnership between themselves, streaming juggernaut Netflix, and the Japanese animation studio, Trigger Inc.

Netflix has made itself fairly familiar with both companies before; having produced The Witcher television show (originating as a series of novels that was later adapted and popularised into a highly successful trilogy of video games by CDPR), as well as curating Studio Triggers previous works, and subsequently licensing their latest anime series, BNA: Brand New Animal.

Based on the 1988 pen and paper role-playing game, Cyberpunk as a franchise has garnered a lot of attention in recent years, due to media outlets and fans alike contributing to the ever-growing hype-spiral since the teaser trailer in 2013. We may have hit peak hype seven years on, but even still, its no wonder that there is interest in the opportunities to expand the franchise (especially since, as of writing, the game wont be released for another three months!).

Those of you who are well versed in the anime industry will be familiar with their productions, and perhaps even their staff. Comprised of notable Gainax alumni, Cyberpunk: Edgerunners is to be helmed by those whove worked on a number of quintessential anime properties, such as Neon Genesis Evangelion, Gurren Lagann, and FLCL. Although the studio is relatively new, the team behind Trigger Inc. has already forged its own legacy as pioneers of action within the anime sphere from the get-go.

With an explosive debut like 2013s Kill la Kill, Trigger left its mark on the anime worlds stage. Instantly establishing a unique art style by way of an overtly expressive, aggressive, diverse, and flamboyantly fluid movement Kill la Kill indulges in its extremes, constantly finding ways to push things further.

Even the premise is absolutely barmy: Transfer student vows to uncover her fathers murderer, leading her into stumbling upon a sentient sailor school uniform; which, together they pursue to dismantle her schools fashion-obsessed hyper-authoritarian regime, wielding only a longsword (thats half of a pair of scissors), and a sheer determination for revenge

This being said, the series is acutely aware of itself; a series where the layers of meta anime tropes can get so dense, that the show itself has its own character and personality.

Where Kill la Kill allows itself to be the crazy horse, high off sticky-toffee apples; the reigns are reeled in when it comes to their next hit Little Witch Academia. A quirky, light-hearted tale of an idealistic and aspiring non-magic born witch, who attends a prestigious academy where it becomes painfully evident that she is severely inept. On the surface, LWA deals with confronting the cynicism and expectation from her peers to be professional; but our protagonist wears her influences on her sleeve, chiefly, her love of a magic performer. All she desires to be is a source of joy and light in the world, where the broader magical society looks down at entertainers as lowly.

Though it is still very much a Trigger production with its trademark chaotic energy and slapstick extremism, the franchise exercises some restraint on the excessive, as it focuses on the more whimsical and magical, as evident in its inspiration of western (namely, British) contemporary novels & mysticism as seen in the likes of the Harry Potter series (and The Worst Witch although that may be too much of a deep cut for those not from the UK!).

As for their latest release, BNA: Brand New Animal demonstrates the best of both aforementioned worlds; developing a structured formula through its plot, characters, and thematic devices. Taking elements of fantasy and action from each show, you get the sense that Trigger as a studio has been honing its craft as a production company throughout the series.

The show deals with the differences and similarities of people who identify as separate from each other in this case, humans and their disdain for anthropomorphic humanoids (known as Beastmen and not to be confused with Beastars a different anthropomorphic Netflix anime series). BNA centers around a teen runaway who inexplicably transforms from Human to Beastman, as she seeks solitude and a solution for her condition in the only city dedicated to Beastfolk.

The mold for Cyberpunk: Edgerunners has been cast and ready to be set since Trigger Inc. released BNA: Brand New Animal. The premise of both these titles parallel neatly along with one another young vagabond vies to survive in a city filled with problems outside their own. Its not hard to imagine that the ultra-violence and creativity of Kill la Kill would seep into the fabric of Edgerunners either; nor would it be a stretch to envision how much of Night City (where the action of Cyberpunk takes place) could come alive, like BNAs Anima City, or as fantastical as Little Witch Academias Luna Nova Academy, and Kill la Kills Honn City.

We dont know too much about the more nuanced aspects of Cyberpunk: Edgerunners, other than what was told from a press release shortly after the formal announcement: A ten-episode series following a street kid making his way up the ranks in wetwork as an Edgerunner (an elusive, high ranking mercenary). Within the lore of the pen and paper series, Edgerunners serve as one of the archetypes available to the player. The Street-kid class is unique to the upcoming video-game, presenting the role as more of a rookie merc than an established hired gun.

Hopefully, sooner rather than later, the Corpos at Netflix or the Rockerboys of CD Projekt Red & Trigger Inc. will release more details about the much-anticipated anime adaptation.

Cyberpunk: Edgerunners is set to premiere on Netflix in 2022

List of those who are confirmed to be working on Cyberpunk: Edgerunners:Director: Hiroyuki Imaishi (Gurren Lagann, Kill la Kill, Promare)Assistant Director: Masahiko tsuka (Gurren Lagann, Promare)Creative Director: Hiromi Wakabayashi (Kill la Kill)Character Designers: Yoh Yoshinari (Little Witch Academia, BNA: Brand New Animal) Yuto Kaneko (Little Witch Academia)Screenplay Writers: Yoshiki Usa (SSSS.GRIDMAN, Promare)Masahiko tsuka (Gurren Lagann, Kill la Kill, Promare).Composer: Akira Yamaoka (Silent Hill series).

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Everything You Need To Know About Cyberpunk 2077s Anime, Edgerunners - Fiction Talk

Cyberpunk 2077 May Repeat the Mistakes of Skyrim | Game Rant – GameRant

While Cyberpunk 2077 will likely be many's game-of-the-year pick this fall, one aspect from the game's previews has been universally criticized.

There's no doubt thatSkyrim is one of the best RPGs on the market. The expansive, seemingly never-ending homeland of the Nords housed numerous expansive quests, bolstered by its free-form RPG mechanics that allowed for unique characters. While sword-wielding warrior builds were probably some of the more common progressions inSkyrim, the melee combat did have its fair share of functional clunkiness. Now, it seemsCyberpunk 2077 is tackling a similar issue with its own melee combat.

Granted, in all fairness,crafting a fully-fledged RPG in a cyberpunk setting means nailing down the gunplay and the unique cyberware abilities first. Even still, one of the most common complaints from early previews of Cyberpunk 2077 has beenthe lackluster melee combat in the game's current state. Visual feedback and evoking weight in melee combat was an issue inSkyrim that CD Projekt Red will likely need to address withCyberpunk 2077, despite being so close to release.

RELATED:Cyberpunk 2077 Developer Addresses Fan Concerns Regarding the Game

For RPGs, it's tough to balance the priorities in development depending on what type of game is being made. ForCyberpunk 2077, melee combat will be just as much of a core gameplay mechanic as the gunplay is. Multiple media previews of the game consistently praised the gunplay as being pretty fantastic for an expansive RPG that's also a first-person-shooter. As for the melee combat, the general consensus is that it's sub par and doesn't necessarily have enough weight or visual feedback behind it for bare knuckle brawling to be enjoyable.

Skyrim evokes a similar problem too, as melee combat just doesn't have enough weight to punches or attacks. Across all weapons, visual and audio cues that make a hit seem strong and impactful just aren't really present in Skyrim. Enemies all start to feel like butter that the Dragonborn is slicing through, and not because the player's character is overleveled. Opponents don't always flinch or fall over when attacked, so combat ends up looking like aWorld of Warcraft combat scenario where one person swings and then the other swings. The player and the enemy's health gauges deplete over time, but the game doesn't evoke the feeling that either is truly fighting another person.

CD Projekt Red's development team has recognized this feedbackand has stated publicly it wants to make improvements toCyberpunk 2077's melee combat in the remaining development time before launch. That gives about three months time for the team to make any tweaks/adjustments beforeCyberpunk's November launch window.Cyberpunk 2077's senior gameplay designer Pawel Kapala has stated thatthe team has fully recognized the issues with melee combat and has already made great strides towards improving it. Kapala specifically mentions visual feedback and the weight of connecting hits on an enemy, a common criticism ofSkyrim's combat.

Of course withSkyrim, the fix nowadays is just to mod the game, which frankly is acceptable for a Bethesda game that's nearly 11 years old now. But forCyberpunk 2077 and CD Projekt Red, that's not the answer for a game that has quite good gunplay already. Plus consideringThe Witcher's solid sword fighting combat, settling for subpar just isn't the move here.CD Projekt Red and Kapala theoretically have enough development time between now and release to hone and refine the combat to evoke a more natural feeling.

RELATED:Cyberpunk 2077 Poll Shows Which Lifepath is Most Popular

Now that's not to say melee combat will become a simulatoryUFC-like experience, as any kind of animation overhaul would take far too long at this point in the development cycle. More than likely the existing combat animations and fighting systems already inCyberpunk 2077 will receive visual and haptic feedback changes to make melee combat more natural. That could be anything from enemy behavior when getting hit by light/strong attacks, adjusting the blocking animation, camera behavior during fistfights, and numerous other minutiae. Often it's the little details that players don't even think about that can bring combat down.

Honing and refining the existing animations and combat feel is all that's likely for now, but it should be enough to make melee combat serviceably good inCyberpunk 2077. Hopefully, CD Projekt Red makes enough adjustments so melee doesn't become a damper on what would otherwise could be many's game-of-the-year pick this fall.

Cyberpunk 2077 launches on November 19 for PC, PS4, and Xbox One. Stadia, PS5, and Xbox Series X versions are planned to release in 2021.

MORE:Cyberpunk 2077 Needs to Avoid Skyrims NPC Problem

Here Are the 10 Highest Rated Games of 2020 So Far

Not actually a distant relative of Bob Dole, Rob Dolen is a Features Writer for Game Rant. Big fan of expansive lore and game analysis, video games are cool. Freedom Fighters is underrated. Probably not good at competitive Halo anymore.

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Cyberpunk 2077 May Repeat the Mistakes of Skyrim | Game Rant - GameRant

The World of Cyberpunk 2077 Beyond Night City | Game Rant – GameRant

Cyberpunk 2077 is arguably one of the most anticipated games of the entire decade. In fact, that anticipation has lasted for almost the whole decade, as multiple delays mean that the first teaser trailer was released over 7 years ago.

Cyberpunk 2077 will be set in the vibrant and violent metropolis of Night City, in the Free State of Northern California. The rest of the Cyberpunk world, however, is also very different from the real. Here are a few key places in the world of Cyberpunk that, though players wont be visiting them in game, are sure to have an influence on Night City and its inhabitants.

RELATED:Areas of Cyberpunk 2077's World Have Been Impacted by Global Warming

The timeline of Cyberpunk and its affects on the world has undergone some different iterations, but in general fans can expect Cyberpunk 2077 to expand upon the timeline and political landscape established in Cyberpunk 2013 and 2020.

For a start, Cyberpunk 2077's Night City used to be Coronado City, California, and isrenamed in 1998 to Night City to honor its founder, Richard Night, after he was mysteriously killed. That same year, the landscape of Californiais changed by a huge earthquake registered at 10.5 on the Richter scale, killing 65000 people in Los Angeles and putting 35% of the city underwater.

New York is also heavily damaged back in 1993 when a small nuclear bomb is detonated by Colombian Drug-lords, killing 15,000 people. In 1998, a drought ravages the Midwest, and over the course of the coming century, chaos in America causes the Unification War which is triggered bythe establishment of Texas and Alaska as free states due to their huge oil reserves and ends in every other state fighting for independence for similar economic reasons.

In Central and South America, over one million contract workers are abandoned in 2010 at the end of the Second Central AmericanConflict War (2003-2010) becoming Nomads and triggering an event called The Long Walk as they tried to return home.

In Europe, the Soviet Union still collapses, but instead becomesthe Union of Sovereign Soviet Republics, keeping its Communist character but giving each state greater independence in a similar way to the USA's new divisions. The United Kingdom falls into political turmoil as the British Monarchy and a new faction called the Martial Law Authority battle for power of the nation.

In Germany, Hamburg is bought by the Euro Business Machines corporation and is peacefully declared an independent nation in 2005. Many other European countries are thrown into chaos over the course of the 21st century. Greeces government is ousted by a military coup in 2007, for example, and becomes an increasingly aggressive force in the region, causing relationships with Turkey to deteriorate further.

In 2013, Portugal sells itself to avoid bankruptcy, while the next year Vatican III is established with the neo-Catholic reformation, abolishing celibacy and allowing female priests. As a result, new conservative sects spring up worldwide. However, the Eurodollar, also called "eddies", becomes the main currency in both Europe and across the world in everywhere outside of the Soviet Sovereign Republics. This is the currency used in Night City.Under this economic union, thenon-Soviet European nations form the European Community.

Japan is one of the biggest military and economic powers in both Asia and the world of Cyberpunk at large. The mega-corporation Arasaka is established in Tokyo and dominates much of the new third world, which now includes America. In 2020, Arasaka began developing its own private army, and during the following Fourth Corporate War, the Japanese government nationalized the corporations' assets within its control to facein the international community, but was unable to reign in the company abroad.

China regains Hong Kong from Britain in 1997 but subsequently loses it to a biological weapons attack. By 2045, Hong Kong is enclosed within a 100-foot wall in order to stop the disease caused by the attack from spreading. It becomes a central base for Alt Cunningham, once girlfriend of Keanu Reeves character Johnny Silverhand, who by then has become a powerful AI. The Second Corporate War takes place between 2008 and 2010 in the South China sea, which destroys millions of lives in the region and causes a huge refugee crisis.

RELATED:Cyberpunk 2077 Dev Responds to Calls for Official Cookbook

In 1997, an event called The Meltdown takes place in Libya, which is covered by a radioactive cloud that also affectsAlgeria and Tunisia, temporarily halting the Islamic Movements. Risk tourism becomes a fad among Europes rich, though they avoid Algeria, dubbed the most dangerous country in the region. By 2019, an Islamic fundamentalist movement reemerges in Algeria after the country suffers considerably as a satellite state of the European Community.

New Zealand becomes host to the Papua New Guinea government in exile when Indonesia invades the country, renaming it East Irian Jaya. In 2010, experimental nano-tech designed to help clean up radioactive waste in Southern Australia gets out of control, taking over huge parts of the desert.

Australia's failure to recognize Aboriginal land causes both protests in the country and boycott from abroad, including New Zealand. Drought hits Adelaide,Australia in 2016, exacerbated by the pollution in the remaining water supply. Arasaka funds a desalination plant so that the Australians can make sea water potable, but in accepting their offer the Australians increase the corporation's influence over their nation.

Cyberpunk 2077 may be set in Night City, but there's no doubt the wider world will have a huge impact on what players can expect from the metropolis. Fans of Cyberpunk will know that nations themselves are increasingly less relevant than mega-corporations, making the far-reaching influence of companies like Arasaka felt all over the world. As a result, the world of Cyberpunk is very multicultural, with a particularly strong Japanese influence.

Furthermore, players can expect to see characters from all over the world who have set up new lives in Night City. With constant refugee crises as disasters and droughts devastate regions annually, Night City is sure to be as diverse as it is divided. For fans of Cyberpunk who want to find out more about the world and timeline of Cyberpunk at large, they can turn to the sourcebooks released for the table top games to which CD Projekt Red's upcoming title is a sequel. It remains to be seen how closely the studio sticks to all the details, but fans can be confident that the world of Cyberpunk will likely feel at once freshand strangely familiar.

Cyberpunk 2077launches November 19 on PC, PS4, and Xbox One, with PS5, Stadia, and Xbox Series X versions also in development.

MORE:Cyberpunk 2077's Star-Studded Voice Actor Cast List

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The World of Cyberpunk 2077 Beyond Night City | Game Rant - GameRant

Cyberpunk 2077 Is An RPG First, One Dev Reassures Fans (VIDEO) – Don’t Feed the Gamers

The recent installment of Night City Wire showed off some impressive gameplay, more on the music, and a lot of weapon action that will be featured in the game. However, after the episode, one developer made sure to reiterate that Cyberpunk 2077 is an RPG first, even with all of the FPS elements.

During a recent Discord discussion with Netrunner 2077 and some members of the community, senior quest designer Miles Tost made sure to reassure everyone that Cyberpunk 2077 is primarily a role-playing game. After all, we saw a lot of shooty bits in the recent Night City Wire episode, and the game is in a first person perspective, which has thrown some folks off. However, rest assured, for the title will run deep with the RPG goodies.

As for how much of an RPG Cyberpunk 2077 is, well, weve seen plenty so far. Everything from choosing a lifepath and customizing your character, to all of the dialogue that comes with these choices as well as the decisions that will need to be made, its going to be deep. Hell, players dont even need to finish the main story to beat the game, so you know there is some interesting things going on there that are related to the role-playing side of things. Plus, fans can go the entire game without killing anyone, so take that, FPS. Seriously, though: Cyberpunk 2077 is an RPG.

Cyberpunk 2077 is set to officially arrive on November 19th for PC, PlayStation 4, and Xbox One. As we approach the dreaded Day 91, lets brace for either disappointing news or one really good meme from the devs. Keep it tuned to Dont Feed the Gamers as this story develops, and for other gaming goodness going on right now, check out the following:

What say you, choombas? Excited to dive into Cyberpunk 2077 when it arrives later this year? Have you ever doubted the RPG-ness of the game? Sound off in the comments section below, and be sure to follow DFTG on Twitter for live gaming and entertainment news 24/7!

If you enjoy this writers work, please consider supporting them bytossing a KoFi their way! Every little bit helps and aims to keep DFTG independent and free of bias. Thank you so much for your support!

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Cyberpunk 2077 Is An RPG First, One Dev Reassures Fans (VIDEO) - Don't Feed the Gamers

From Cyberpunk 2077 to God of War: video games that will become anime and comics – Asap Land

The past year has seen the announcement of a multitude of reinterpretations, spin-offs and adaptations of videogame productions ready to bring their imaginaries to new media. You can easily range between genres and expressive channels: just think of the awaited TV series of The Last of Us or the success of the three anime seasons dedicated to Castlevania. An intriguing trend, which in no way seems to be going to slow down in the foreseeable future. The coming months will in fact be full of projects capable of drawing the attention of video players in the direction of other forms of entertainment, ranging from comics dedicated to God of War is Horizon: Zero Dawn to themed Netflix series Cyberpunk 2077 or Dragon's Dogma. We therefore propose an overview of the main ones comics and anime productions dedicated to video games currently in progress. Enjoy the reading!

We can only open our review with a production dedicated to one of the most anticipated titles of this year: Cyberpunk 2077. Ready to ferry players towards the next-gen, CD Projekt RED's ambitious RPG will debut on the gaming market on November 19th. The Polish software house, however, does not hesitate to already look to the future of IP, with an intriguing project destined to see the light in the course of 2022.

With the announcement of Cyberpunk: Edgerunners, the intention to expand the game universe through a anime series, created in collaboration with none other than Netflix. It will be to shape it TRIGGER study, a famous Japanese animation studio that has produced series such as Kill la Kill is Little Witch Academia, in addition to the feature film Promare. The team is not new to forays into the gaming world; on this front we can for example cite the work done on the Action RPG indivisible, for which the art team created the introductory sequence and some animations.

In presenting the project, the Polish software house affirmed the strong desire not to reproduce in an animated key what will be the contents of Cyberpunk 2077. For this reason, Cyberpunk: Edgerunners will tell a completely autonomous story, but set in the same universe as the video game. The background will still be the neon lights and dark alleys of Night City, but every other constituent element, starting from the characters, will be different. CD Projekt aims to make the series a potential entry point for the exploration of RPG, through a production capable of being attractive both for gamers and for those who do not know Cyberpunk 2077.

The narrative arc of Cybepunk: Edgerunners will unfold over ten episodes, and will tell the story of a street boy. Against the backdrop of a Night City that never sleeps, in which the human being has made the transformation of the body through artificial grafts a real religion, the protagonist will turn into an outlaw and a mercenary, to face a life in which hears of have nothing more to lose. Intriguing detail, the anime will be embellished with the soundtrack of Akira Yamaoka, former Sound Designer of the series silent Hill. For further details, on the pages of Everyeye you will find a preview of Cyberpunk: Edgerunners, written by our Alessio Micheloni.

At home CD Projekt RED, however, were not satisfied with an animated series to accompany the debut of the new IP. Intended to support the franchise of The Witcher, the latter it will also turn into a comic production; specifically, what appears to be a spin-off of Cyberpunk 2077, published by Dark Horse Comics. entitled Cyberpunk 2077: Trauma Team, the work accompanies us to the discovery of the Trauma Team International, one of the great Megacorporations of the paper GDR of Cyberpunk. Specialized in the recovery and rescue of its policyholders, the company offers medical assistance services to be implemented in every context and conducted for this reason by paramedics in combat gear.

A paradox like any other that takes place in the streets of the dystopian Night City, within which the story of Nadia. The protagonist is in fact a paramedic assistant who was involved in a rescue mission that ended in tragedy. The only survivor, the woman agrees to put her skills at the service of a further recovery operation for Trauma Team International. Nadia and her new team, however, will soon find themselves embroiled in an even more lethal and dangerous situation.

To give shape to the comic we find an interesting creative duo: the script bears the signature of Cullen Bunn (Harrow County, Uncanny X-Men), while the drawings are the work of none other than Miguel Varderrama (Giants). At the moment, it is not known what the exact number of books they will make up is Cyberpunk 2077: Trauma Team, but the first issue is expected for the next September 9.

Let's stay in the world of comics to discuss an IP that is already more than established, which over the years has become a real Sony icon. Following the huge critical and public success of Cory Balrog's God of War for PlayStation 4, Kratos in fact, he made his debut in print with a prequel adventure. Released in 2018, the God of War miniseries offered us a brief but intriguing insight into the relationship that binds the Ghost of Sparta to Faye and the young Atreus, as well as the inner struggle experienced by the protagonist to tame his own inner fury.

Well, a further comic production now returns to place itself among the events narrated in God of War III and in God of War, with the promise of taking us even further back in time. The new miniseries, baptized God of War: Fallen God, brings together the same artistic tandem of the previous saga, with Chris Roberson to the script, Tony Parker to the drawings and Dan Jackson to colors. Published in English by Dark Horse, the story narrated in God of War: Fallen God will unfold in four volumes, to follow the fate of Kratos at the end of the first videogame trilogy.

After ending the bloody hunt for Zeus, the Phantom of Sparta he now seems eager to leave everything behind, including his homeland. Deluding himself that he can control what his soul has turned into after the relentless pursuit of ferocious revenge, Kratos takes his steps towards a mysterious desert. On the sands he now paints bloody footprints, in a path that will bring his fury to unleash against the only enemy now at hand: himself. A battle that the protagonist does not seem to be able to win and that will lead him dangerously close to the abyss of madness. Originally expected for summer 2020, with the first volume out on June 24, God of War: Fallen God was postponed by Dark Horse following the COVID-19 emergency. The publishing house has announced that the miniseries will debut in the course of 2021, but at the moment a precise launch date is not available.

Let's stay at Sony, to briefly present another comic production inspired by a first party title of the videogame giant. We are talking about Horizon: Zero Dawn, an appreciated open-world that originally debuted on PlayStation 4 and recently also landed on PC. Developed by Guerrilla Games, a team known for their work on the Killzone, the game is shaped with the advanced Decima Engine, the graphic engine that later, offered by its authors to Kojima Productions, would also give shape to the Death Stranding by Hideo Kojima.

The entrance of Horizon: Zero Dawn in the world of comics is signed by Titan Comics, a publishing house that has assembled a very interesting creative team. In fact, we find the script Anne Toole, one of the authors involved in the drafting of the events narrated in the video game, flanked by the drawings by the artist Ann Maulina. Also in this case, the printed word will not reproduce what has already been experienced by console and PC users, but will offer a unreleased story arc, which is placed after the events narrated in the open-world.

At the center of the events we will find the character of Talanah, strong and skilled huntress, bewildered by the sudden death of dear friend Aloy, protagonist of the creation of Guerrilla Games. To complicate her existence the sudden emergence of a new and dangerous threat, which will force her to give up all her courage. Engaged in yet another hunt, Talanah will discover that a new generation of mechanical creatures are now trampling the earth's soil. The first volume of the series has debuted in the USA on 5 August. While waiting to learn where its evolution will lead us, the reading of Horizon: Zero Dawn could represent an interesting appetizer waiting for Horizon: Forbidden Lands, the sequel to the PS4 game, expected exclusively on PlayStation 5 in the course of 2021.

After the extraordinary success of the debut season of The Witcher TV series, Netflix has no intention of limiting investments in the franchise, which is also preparing to welcome a anime-style feature film. The reconstruction of the world of the Strigo carried out by the streaming giant obviously lays its foundations in the novels of Andrzej Sapkowski, but the imagery and aesthetics of The Witcher also draw heavily from videogame works by CD Projekt RED.

A short distance from the announcement of The Witcher: Nightmare of the Wolf, Netflix confirmed that the protagonist of the film will be Vesemir, the witcher who followed Geralt of Rivia's training. The production will take us on a journey into the past, at a time when Vesemir himself began his training as a Witcher, after being claimed by the mysterious Deglan through the Law of Surprise, made famous by the TV series.

To sign the project, we find two prominent characters in the script: Lauren Schmidt Hissrich is Beau DeMayo, respectively showrunner of The Witcher and author of the third episode of the series, "Traitor Moon". In terms of aesthetics and animations, it will be MIR study to affix their signature a The Witcher: Nightmare of the Wolf. Korean animation team, the latter is best known for their work on The Legend of Korra.

Is always Netflix is the parent company that hides behind a further revival in an anime key of a videogame universe: that of Dragon's Dogma. RPG signed by Capcom and debuted on Xbox 360 and PlayStation 3 during 2012, the title later found space on other platforms. In the revised edition Dragon's Dogma: Dark Arisen, the game has in fact also landed in PC, PlayStation 4, Xbox One and Nintendo Switch libraries.

In this case, the anime it seems to present itself more as an adaptation that not as an extension of the imagery created by Capcom. The synopsis proposed by Netflix does not differ significantly from the plot of the dark fantasy adventure. The protagonist identified for Dragon's Dogma he is therefore a boy determined to embark on a journey in search of revenge. The object of his hatred is none other than a dragon, responsible for having ripped out his heartwhile allowing him to stay alive.

With his chest scarred by a deep scar, the young man will find himself taking an active part in a centuries-old conflict, which sees dragons opposing the mysterious figure of Arisen, chosen to face the mythological creatures. The making of the anime of Dragon's Dogma was entrusted by Netflix to the animation studio Sublimation, former creator of 009 Re: Cyborg is Walkin Meat. The wait to be able to observe the result of the production effort will not be long: the debut of the series is in fact expected on Netflix for the 17 September 2020.

From a Capcom IP we pass to a Square Enix production: The World Ends with You. Released for the first time on Nintendo DS in 2007, the peculiar RPG signed by Testusya Nomura sees the protagonist Neku Sakuraba, a young Japanese expert in Shibuya, a well-known district of Tokyo. Not even time to realize what happened to him, that boy finds himself involved in the "Game of Demons", a tournament that pits the unfortunate victims against each other in a series of challenges hatched by cynical Shinigami. The prize up for grabs? Come back to life!

On the occasion of this year's Anime Expo Live, Square Enix has announced plans to make an anime series inspired by The World Ends with You, with release expected for 2021. A first teaser trailer presented us with what will be the aesthetic solution adopted by the animators stationed at the animation studios DOMERICA (Flying Witch Petit) is Shin-Ei Animation (Mysterious Joker, Doraemon).

Interesting element, Square Enix confirmed that The World Ends with You: The Animation will not propose a simple adaptation of the video game, but, on the contrary, will make some intriguing changes. Among these figures, for example, the desire to update the production, painting a contemporary Shibuya and not strictly linked to its 2007 version. At the moment, however, distortions of the narrative plot seem to be excluded, but to be sure it will be necessary to wait for new information. For further details, on the pages of Everyeye you will find a rich preview of The World Ends With You: The Animation, by our Antonello "Kirito" Bello.

Finally, we close our roundup with two productions not officially announced, both linked to home IPs Blizzard Entertainment. As we told you in our special on the Overwatch and Diablo anime series, a bizarre leak seems to have revealed the intention to transpose the two fascinating universes into the world of animation.

References to the productions were in fact revealed on Nick van Dyk's Linkedin profile, former president of Activision Blizzard's film and TV division. Subsequently removed, the latter have not yet found confirmation from the videogame giant. However, very few potential details were leaked on that occasion; for Overwatch, in particular, only a generic one was mentioned "animated series". A little richer the picture traced for Diablo, apparently destined to land on Netflix in a "anime style TV adaptation"BlizzCon 2020 was canceled due to the COVID-19 emergency, but it will be replaced by a digital event scheduled for early 2021: could this be the right occasion to find out more?

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From Cyberpunk 2077 to God of War: video games that will become anime and comics - Asap Land

2021 Genesis GV80 Preview: Hands On With the New Luxury SUV – AutoGuide.com

Ive seen the Genesis GV80 more this year than some family members.

Some of that has to do with, well, you know, but the other reason is that this mid-size SUV is a monumental model for the fledgling luxury brand. Ask anybody on the street what sells in the 2020 car market and theyll tell you its SUVs. Genesis has been racking up awards pretty much since inception for its cars, but the volume play was always going to need to be a high-rider.

Thats why we spent a portion of a day with the GV80as well as the G80, which will get its own preview articlepoking around the impressive new rig. Since its debut at the start of the year, Genesis has slowly trickled out more information on what prospective buyers can expect when it touches down soon. Its still a little while before we can drive it, but here are the highlights from our hands-on time with the new SUV.

Photo by Harry Zhou

Both Kia and Hyundai have been killin it with sales of the Telluride and Palisade. It wouldve been easy for Genesis to simply crib that platform for its first SUV. Instead, the brand is underpinning the GV80 with a foundation of its own design, one that also supports the 2021 G80 mid-size sedan. The rear-drive-based architecture should afford the GV80 the necessary level of dynamicism to challenge the BMW X5 and Mercedes-Benz GLEthough of course, well have to wait until proper go behind the wheel to know for sure.

Of course, the GV80 will also offer all-wheel driveand in fact, only that in Canada. Two turbocharged engine options will be available in both markets: a 2.5-liter four-cylinder and a 3.5-liter V6. The larger engine will only be available with AWD. These are both powerful engines, with the smaller model putting out an even 300 hp and 311 lb-ft, while the six-pot produces 375 hp and 381 lb-ft. For those keeping score at home, those stats compare favorably to the four- and six-cylinder models from the Germans.

Photo by Harry Zhou

Genesis may have debuted its current design language on the facelifted 2020 G90 sedanfull review on that coming later this monthbut the GV80 is the first clean-sheet example of the look. The face, with the bold diamond-shape grille and the twin-line headlights framing it, isnt subtle. But move around to the side and the flanks are clean and unfussy. The designers have split the difference between upright practicality and high-angle style for the rear hatch glass too, emphasizing the rear haunches. Enormous wheels are par for the course these days, and the GV80 obliges with massive 22-inch wheels in this pre-production form. Smaller rolling stock will be available too.

While Im sure not everyone will dig the new family look, its just that: familial. With the opportunity to look at the GV80 and G80 together, theres a cohesiveness to their looks without falling into Xerox territory. The GV80 is not simply a higher-riding G80 station wagon.

Genesis Canadas Jarred Pellat explains that designer SangYup Lee looks at the lineup as a chess set. When you look at a chess set, maybe its a marble set or a wood set, you can tell that all the piecesthe pawns, the rook, the queen and the kingtheyre all from the same family, explains Pellat. They all have the same finishes, they all have that same identity. But theyre all a different shape, they all have their own unique character. Thats what the Genesis lineup is becoming.

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Photo by Harry Zhou

Coming in either two- or three-row forms, the GV80 will likely be more of a family-hauling road trip machine than any Genesis before it. So the automaker has loaded it up with a laundry list of features, both standard and optional, that should help melt away the miles for driver and passengers alike.

Lets start with the Road Active Noise Cancellation (RANC). The system uses sensors and microphones dotted around the car to pick up exterior noise, and then pumps opposing sound waves through the sound system to cancel it out. It results in what Genesis is calling one of the quietest cars you can buy. Optional massaging seats should also go some way to relieving stress on the road.

The GV80 features an augmented reality navigation system. Similar to other setups on the market, this displays a live feed from the front camera on the central infotainment screen, with arrows overlaid. The nose of the GV80 also houses sensors to scan the road ahead to pre-emptively adjust the suspension for any uneven surfacesa segment first. Again, well have to reserve judgment for our first drive, but all of the above should combine to provide a serene mile-muncher.

Not all of the GV80s family-friendly appeal comes from high tech toys, either. One of the simplest design features is the height of the exterior door panels. The door takes the sill section with it on opening, ensuring no mud or road grit gets all over your pant leg on entrance or exit. Clever.

As I mentioned earlier, the GV80 will be more of a family vehicle than previous Genesis models. To that end, it comes with a panoply of standard safety features to keep you and yours safe. These include the usual automated emergency braking, lane keep assist, and blind spot warning systems. The latter uses side-mounted cameras to show a live feed in the infotainment screen whenever a turn signal is active. In addition, the GV80 will feature a rear cross-traffic alert and a driver attention warningon every trim.

Higher tech includes a machine learning-powered adaptive cruise control. This world-first application learns from the driver and then applies their habits to its own driving when active. Highway Driving Assist II is a partially-autonomous driving aid that helps in heavy traffic, including performing safe lane changes when the driver activates the turn signal.

Should the worst happen, the GV80 is equipped with 10 airbags. These include a segment-first central airbag between the driver and front passenger, keeping them safely separated in the case of an accident.

Photo by Harry Zhou

If youre considering the GV80, please do yourself a favor: buy one of the unique interior color schemes.

Nothing says old money quite like another somber, black leather interior. The GV80 offers a unique green-and-brown interior scheme that sets it apart from the pack. Diamond-quilted leather seats look good and are eminently adjustable. Even the little kneepads lining the center console are diamond-quilted. The fit and finish, even on this pre-production model, feels well on par with the establishment.

The overall interior design is calming and minimalist. A huge 14.5-inch touchscreen sits atop the dash, though users can also interact with it via a center console-mounted dial. Thisand all the dials found inside the GV80has that sort of tactile response found on a classic iPod. It clicks as you spin it, but can also be poked and prodded for simpler four-direction navigation. The center of the scroll wheel also accepts handwriting.

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These multiple input options were an intentional part of the design according to Genesis; the goal is to allow users to interact with the GV80 in whichever way they find most comfortable. Thats important: this is the biggest rethink of the brands infotainment since launch, and these systems ease-of-use are increasingly important to customers. Look no further than the annual J.D. Power Initial Quality Study, where Genesis scored as the top luxury brand for 2020. On initial encounter, the new system is naturally more complicated than the current one, but not so much that a few minutes of fiddling doesnt fix.

Theres other trick tech in here too. Look ahead of the steering wheel and youll find a head-up display and the worlds first 3D digital instrument panel. Its a clever bit of kit that I cant trick during my short time with it, but those that prefer a flat display will be happy to know it can be turned off.

Photo by Harry Zhou

So a static poke around the GV80 suggests the upstart will upset the established order when it lands later this year. With an entry price of $49,925 for a rear-drive four-pot in America including destination, it will seriously undercut rivals while maintaining a level of luxury buyers expect for that sort of sum. Canadians will be looking at $64,500 to hop inthough part of that has to do with standard all-wheel drive and added features. But the most important question remains: how does it drive?

Like it did to so many other car launches this year, COVID-19 delayed the GV80s roll-out too. Well be getting behind the wheel soon though, and then well really know for sure whether or not Genesis has another hit on its hands. Based on this latest meeting with the GV80 however, and the young brands track record, we wouldnt bet against it.

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2021 Genesis GV80 Preview: Hands On With the New Luxury SUV - AutoGuide.com

We Can Sue, Too: An Interview with Brooke Goldstein, Founder of The Lawfare Project – The Jewish Press – JewishPress.com

Photo Credit: Mark Harkin / Wikimedia

When Kuwait Airlines refused to sell tickets to Israelis, The Lawfare Project sued, forcing it to cancel all its inter-European flights and its popular JFK-London route.

When Saudi Arabia wouldnt allow Israeli players to participate in a chess tournament two years ago, The Lawfare Project again sprung into action, and the International Chess Federation ultimately moved the tournament to Russia.

Numerous Jewish organizations protest insults against Jews or Israel, but The Lawfare Project was founded 10 years ago to fight back in a very specific way: through the courts. And so far, it has achieved some remarkable victories.

To learn more, The Jewish Press recently spoke to its founder, Brooke Goldstein.

The Jewish Press: Whats your background?

Goldstein: I was born and raised in Canada. I went to McGill University and then to Cardozo Law School.

I come from a very proud Zionist Jewish family. My grandparents are Holocaust survivors, and I was raised with a love for my identity. I hope to give the same love for Jewish history and the Jewish people to my children.

Why did you start The Lawfare Project?

When I was in law school, I worked as in-house counsel for Daniel Pipes at the Middle East Forum, and I was also running The Legal Project, which was a litigation defense fund for people in the counter-terrorism and moderate Muslim communities who were being sued for speaking about radical Islam.

I started studying where the money for these lawsuits came from and learned that there were hundreds of thousands if not millions of dollars being funneled through organizations like the Council on American-Islamic Relations and Muslim Legal Fund.

I also studied how organizations like the ACLU and NAACP operate, and it occurred to me that the way that you really make change in this country is through seminal civil rights lawsuits.

I realized, though, that there has never been a Jewish litigation defense fund or a Jewish civil rights movement in this country. So in 2010 I founded The Lawfare Project, and since then we have filed over 80 groundbreaking civil rights cases in almost 20 jurisdictions around the world.

What would you say have been your biggest victories?

The most recent significant victory was a settlement we entered into with the National Lawyers Guild. We sued the National Lawyers Guild which is one of the oldest lawyers guilds in the United States for discrimination against our client, an Israeli company.

The guild had passed a resolution not to do business with Israelis, but enforcing such a resolution violates New York States anti-discrimination law. Just like you cant have a restaurant with a sign No Chinese allowed or a bar with a sign No blacks allowed, you cant have a business and say, No Israelis allowed.

Our client had attempted to buy ad space in the National Lawyers Guild annual journal, and the guild sent an e-mail back saying: Sorry, we dont do business with Israelis. So we sued them. The National Lawyers Guild realized it didnt have a case, so it settled with us and changed its anti-discrimination policy.

Its quite significant because it shows that if you engage in BDS, you will be held accountable, you will be sued, and eventually if youre stupid enough to go to court you will be held liable. In this case, they did the smart thing and settled and reversed their policy. Theyre doing business now with the Israeli company.

Is it true that you once successfully sued Google?

We have a lawyer who operates out of Europe, and he filed a legal action against Google. We ended up reaching an understanding with Googles lawyers to block defamatory content against the Jewish people, including material that promotes Nazi ideology and denies the Holocaust.

Our lawyer in Europe is now working very closely with Googles in-house counsel to make sure Google is following its own policy and abiding by European law, which is actually much more strict on Internet providers and search engines [than America] when it comes to content that defames people because of their race or ethnicity.

You also apparently once successfully blocked Hamas or Hezbollah from broadcasting in America.

Yes, that was actually one of our first legal actions. An intern who was working with us pointed out that Hamas TV and Hezbollah TV were being broadcast illegally in the United States through two U.S.-based companies. So we were able to put together a legal memo and share it with law enforcement, and they took down the two channels.

One of your more impressive victories is one you scored against Kuwait Airways. Can you talk a bit about that?

Its actually an ongoing action. We forced Kuwait Airways to cancel its route from JFK to London because its illegal in this country to discriminate against someone based on his or her national origin, which is exactly what Kuwait Airways is doing. [It bars Israeli from its flights.]

Weve also filed several actions against Kuwait Airways in different European jurisdictions. Some have been more successful than others, but we were successful in the sense that we got Kuwait Airways to cancel all its inter-European flight paths.

The last challenge is to work with European countries to ensure that their anti-discrimination laws are enforced even for Kuwait Airways flights that fly to Kuwait because we believe its completely unacceptable in the 21st century in the West to allow companies to do business in our countries and make money while engaging in barbaric discrimination.

Your organization has also been involved in fighting European laws that require products made in the West Bank to be labeled as such. Can you talk about that?

We were retained by Psagot, which is an Israeli winery in Judea and Samaria, and we challenged a French regulation that required Jewish products made in Judea and Samaria to be labeled a certain way which is discriminatory.

We ended up going all the way to the European Court of Justice, but in a really stunning ruling last November, it basically said that consumer protection requires labeling products to indicate anything a consumer may desire to know vis--vis ethics, and this includes whether or not a product is made by a Jew or a Muslim in the so-called disputed territories.

It was an outrageous and shocking decision that will have enormous implications and ripple effects. It has really opened the floodgates for consumers to sue companies for all sorts of things. For example, if youre buying a product form the United States and you want to know whether the owner of the manufacturing company voted for Trump, you should be able to demand, as an ethical consumer, that that information appear on the label.

I think courts are quickly going to realize how untenable enforcement of this European Court of Justice ruling really is.

Whats the most recent case youve taken on?

Well, we recently filed a Freedom of Information Law (FOIL) request to find out what was really was behind the blatant discriminatory treatment of the Jewish community when it came enforcing coronavirus regulations.

I think its pretty obvious that [Mayor Bill] de Blasio singled out the Jewish community. He blamed the Jewish community for the spread of the coronavirus and threatened members of the Jewish community with arrest.

You cant treat two categories of people differently based on their religion or viewpoint. The government cant say its okay to gather to protest for Black Lives Matters, but its not okay to gather to pray. If you have a regulation, it has to be applied equally across the board to all people regardless of their religion or skin color.

How many lawyers does The Lawfare Project have?

Right now, we have four full-time in-house staff including myself. We have one lawyer who works for us based out of Europe, based in Spain. And then we have a network of over 400 lawyers and over 35 major law firms that have dedicated themselves to working pro bono, or reduced rate, on cases we bring to them.

Why would they work pro bono or at a reduced rate?

Ive spent the last 11 years of my life recruiting firms and lawyers really, the best of the best. We have the top law firms and minds in the world working on our cases.

I think our cases appeal to them because were really at the forefront of the Jewish civil rights movement. Were using the legal system in a way that enforces the basic civil rights of the Jewish community which should have been done 50 years ago.

I think theyre also very moved by the quality of the cases and the plight of the plaintiffs that we bring to them. One of our clients, for example, was punched in the face at Temple University and subjected to anti-Semitic epithets. Theres no place for this in the United States or in the 21st century.

You once said the change you can make with one lawsuit or even one legal letter is enormous. So you dont even have to go to court? A letter does the trick?

Yes. And Id like to think that most of the time the people we write letters to have just forgotten what their obligations are under the law. Were just reminding them, and they do the right thing.

How often does a letter work?

Very often. Id say nine out of 10 times. A lawsuit is always the last resort. You dont want to waste your time and money in a court.

And were not in this game for monetary damages. Were in this game to change the national dialogue, to remind people and educate people that Jews deserve equal protection; that the civil rights laws that apply to other communities to the black community, to the Muslim community, and to women also apply to Jews.

Some people believe our country is too litigious. By taking all these actions, are you contributing to this litigious atmosphere? Or is it your contention that if every other group is doing it, we have to do it as well and that the benefits outweigh the costs?

The beautiful thing about living in a liberal democratic society is that the way you enforce change is not through violence. Its through lobbying, legislation, and the court system. Its a beautiful thing that if you have been wronged, you are able to negotiate a settlement with someone or go to a court of law and have a judge rule on the dispute.

Were not rioting. Thats not how we enforce change in this country. We enforce change civilly by using the court system. And Jews have every right to enforce their civil rights. The rights enjoyed by women, by blacks, and others in this country are all products of seminal civil rights cases that were brought to the courts, and they changed the fabric of our society.

When people accuse us of being a litigious society, the last thing I think theyre talking about is civil rights litigation. Were not talking about ambulance chasers. Were talking about plaintiffs bringing extraordinarily important cases before the courts of law of this country to enforce principles that every other minority community will benefit from.

As a minority community, we deserve equal protection. And thats the way forward to launch a civil rights campaign in this country to demand that we be treated with respect like every other minority community.

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We Can Sue, Too: An Interview with Brooke Goldstein, Founder of The Lawfare Project - The Jewish Press - JewishPress.com

This Trawlers Haul: Evidence That Antibodies Block the Coronavirus – The New York Times

A fishing vessel that left Seattle in May returned with an unexpected catch: the first direct evidence in humans that antibodies to the coronavirus can thwart infection.

More than a hundred crew members aboard the American Dynasty were stricken by the infection over 18 days at sea. But three sailors who initially carried antibodies remained virus-free, according to a new report.

Although the study is small, it addresses one of the most important questions in the pandemic: whether the immune response to one bout with the virus protects against reinfection.

Knowing the answer to this question is critical for vaccine design and epidemiology, tweeted Jesse Bloom, an evolutionary biologist at the Fred Hutchinson Cancer Research Center in Seattle and one of the studys authors.

The study was posted online last week and has not yet been published in a peer-reviewed journal. Still, the finding set off optimistic chatter among scientists, who have been relying on monkey studies for evidence of antibodies potency.

I thought it was very exciting good enough news that I was telling my family about it, said Michal Tal, an immunologist at Stanford University who was not involved in the work.

Several research teams have reported that an encounter with the virus triggers a robust immune response in most people, including in those who may have been only mildly ill. And the vaccine candidates now in trials also seem to elicit strong neutralizing antibodies, the kind that can block the virus.

But the amount of those antibodies needed to prevent the virus from returning is unclear. Scientists measure neutralizing antibodies in titers, an indication of their concentration in the blood.

The three sailors who remained protected from the virus had widely varying titers; two had only moderate quantities, a finding the researchers said was reassuring.

People have been so worried about the titers, and the titers going down, Dr. Alexander Greninger, a virologist at the University of Washington in Seattle, said.

The results indicate even moderate titers prevented reinfection in a situation in which exposure to the virus was high, he said: These are attainable titers, right? Hopefully, itll be helpful to see, and makes make me very optimistic about the vaccines.

The American Dynasty carried 113 men and nine women. All crew members had been tested for both virus and antibodies as part of a routine screening before setting sail. (The researchers did not have access to the results from two members.)

The trawler returned to shore after 18 days at sea when a crew member became ill enough to need hospitalization. The sailors were tested for the presence of virus and antibodies again and for up to 50 days after their return.

The three sailors confirmed to have neutralizing antibodies did not test positive for the virus during the course of the study; 103 of the remaining 117 became infected.

These numbers may be small, but theyre highly significant, Dr. Greninger said.

A lot of people, when they see this are like, Oh come on, it could be due to random chance, he said. In fact, the likelihood that the results are just chance is extremely low, he added.

Updated August 17, 2020

Other experts agreed. Just looking at the numbers, it becomes clear that its unlikely that all of these three people were protected by chance, said Florian Krammer, an immunologist at the Icahn School of Medicine at Mount Sinai in New York.

Dr. Krammer and his colleagues are tracking antibody levels in people who have recovered from the coronavirus once to see at what point they might be vulnerable to reinfection. The team began with people in New York, but the virus is circulating at such low levels in the city now that Dr. Krammer and his colleagues have had to expand the study to other locations.

Data from vaccine trials also will identify the antibody titers required to disarm the virus. But in the meantime, this is the first evidence in humans, Dr. Krammer said. It made my weekend.

The study raised other questions. Based on the Abbott Architect assay, six of the 120 people tested before the boats departure had antibodies to the virus indicating prior exposure.

But when the researchers reanalyzed those samples using more sophisticated tests, only three of the six were confirmed to have antibodies, suggesting that three test results were false positives.

The Abbott test is advertised as returning fewer than one false positive for every 100 samples. Thats a little concerning that the Abbott may be a little less specific than we thought, Dr. Tal said.

The researchers also looked at antibodies in the blood, as most teams do. But those levels may not be the same as those in the nose or in saliva, the two major entry points for infection, Dr. Tal added.

Were looking in the wrong place, she said. If we want to look at protection from reinfection, we need to be looking in the nose.

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This Trawlers Haul: Evidence That Antibodies Block the Coronavirus - The New York Times

NIH imposes ‘outrageous’ conditions on resuming coronavirus grant targeted by Trump – Science Magazine

Michael Lauer, deputy director for extramural researchat the National Institutes of Health

By Meredith WadmanAug. 19, 2020 , 10:55 AM

Sciences COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation.

The National Institutes of Health is requiring a small nonprofit research organization to take unusualand perhaps impossiblesteps to end a controversial suspension of an NIH grant related to bat coronavirus research in China. NIHs conditions for reinstating the funding to the EcoHealth Alliance are outrageous, former NIH Director Harold Varmus told The Wall Street Journal (WSJ) in an article published today that first reported the agencys demands.

The controversy began in April, after President Donald Trump complained about NIHs grant to the EcoHealth Alliance because it involved researchers at Chinas Wuhan Institute of Virology (WIV). Conservative commentators, Trump, and Trump administration officials have asserted, without evidence, that the novel coronavirus that causes COVID-19 escaped from WIV. Shortly after Trumps complaint, NIH abruptly canceled the grant, stating that its goal of studying bat coronavirus spillovers into humans did not align with agency priorities. NIHs move drew extensive criticism from the scientific community.

Last month, NIH Deputy Director for Extramural Research Michael Lauer sent the EcoHealth Alliance a letter stating the agency was reinstating the grant, but also instantly suspending it again pending the completion of certain actions. (ScienceInsider has now independently reviewed a copy of the 8 July letter.)Among the conditions included:

NIH declined interview requests for Lauer and agency Director Francis Collins, saying in a statement: NIH does not discuss internal deliberations on specific grants.

The EcoHealth Alliance said in a statement that NIHs letter cynically reinstates and instantly suspends the EcoHealth Alliances funding, then attempts to impose impossible and irrelevant conditions that will effectively block us from continuing this critical work.

Varmus, one of 77 Nobel laureates who wrote to current NIH Director Francis Collins in May demanding that he review the grants initial cancellation, told WSJ that NIHs list of conditions for reinstating the funding is outrageous, especially when a grant has already been carefully evaluated by peer review and addresses one of the most important problems in the world right nowhow viruses from animals spill over to human beings.

Peter Daszak, the EcoHealth Alliances president, called out Collins in an interview with ScienceInsider today, saying: It undermines biomedical science to give in to politics. I think thats a failure. And I think that Dr. Collins fell at the first hurdle. When challenged by the White House to cancel this grant he just gave in.

Jeremy Berg, who directed NIHs National Institute ofGeneral Medical Sciences from 2003 to 2011, notes that Collins is a political appointee who serves at the presidents pleasure. (Berg was also editor-in-chief of the Science family of journals until 2019.) He says: The question for anybody in [such] a leadership position is: Is there a line that you are not willing to cross? And that you think it would be more appropriate to stand on principle and resign rather than to give in? In my view, that line has been crossed with this.

With reporting by Kai Kupferschmidt.

*Update, 19 August,5:10 p.m.: This story has been updated to include additional material from NIHs 8 Julyletter to the EcoHealth Alliance,a statement from NIH,and comments from Jeremy Berg and Peter Daszak.

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NIH imposes 'outrageous' conditions on resuming coronavirus grant targeted by Trump - Science Magazine

Coronavirus updates: University of North Carolina temporarily suspends fall sports; Pope warns against the rich getting vaccine first – USA TODAY

You can work from home without feeling so isolated. Here are some great ways to stay connected with your team. USA TODAY

Florida, one of the hardest hit states from the coronavirus, just registered its 10,000th death due to COVID-19.

It came after the state recorded 174 new deaths Wednesday, giving it a total that's fifth highest among states around the country. It has recorded more than 584,000 cases of COVID-19 so far.

The virus, meanwhile, continues to play havoc with colleges' attempts to reopen classes.

A day after officials at University of North Carolina at Chapel Hill decided to pivot to online classes afterat least four clusters of outbreaks in student living spaces, North Carolina State University reported its firstcluster of positive cases in off-campus housing.Also Tuesday, the University of Notre Dame said it was movingto online classes for two weeks in hopes that infections won't surge.

And sports fans who thought they could get a break from the coronavirus fallout can't catch a break: new NFL rules will keep mascots and cheerleaders -- as well as sideline reporters -- off the field.

Some significant developments:

Today's numbers:The U.S. has 5.4million confirmed infections and more than 171,000 deaths. Worldwide, there have been more than 781,000deaths and 22.1 million cases, according toJohn Hopkins University data.

What we're reading:Wearing a mask inpublic restrooms should be mandatory during thepandemic, researchers say, because there'sincreasing evidence that flushingtoilets and now urinals can release inhalable coronavirus particles into the air.

This file will be updated throughout the day. For updates in your inbox,subscribe to the Daily Briefing.

Tourists visiting The Strip could befueling the pandemic,according to a ProPublica investigation. An analysis of smartphone data during four days,a Friday to Monday in mid-July,revealed how most of theU.S.is connected to Las Vegas a likely hot spot of COVID-19 spread.

During that time frame, about 26,000 devices were identified on The Strip, according to data mined by the companiesX-ModeandTectonix. Some of those smartphones thentraveled to every state on the mainland except Maine.

Heres a look at where those devices ended up during thosesame four days, according to Propublica:

The cellphone analysis highlights a reason the virus keeps spreading and shows how travel to Las Vegas could be fueling the pandemic, according to health officials.

Ed Komenda, Reno Gazette Journal

Just 48 hours after saying a COVID-19 outbreak on campuswouldn't affect plans to play football this fall, the University of North Carolina has suspended all athletic activities through at least Thursday afternoon. In addition, all recreational facilities on the Chapel Hill campus willbe closed to students, coaches and staff.

"After consulting with our health experts and University leadership, we are taking this action to protect our students, coaches and staff,''UNC athletics director Bubba Cunningham said. "We want to make sure we continue to do everything we can to ensure that that our teams, campus and community remain healthy.''

The school welcomed students back to campus for in-person classes last week, butafter at least four clusters of COVID-19 outbreaks,university officials reversed course and moved all classes online.

Steve Gardner

Georgia Gov. Brian Kemp defended his administrations handling of the coronavirus pandemic in fiery remarks Wednesday after a report from the White House coronavirus task force said Georgia led the nation last week in new cases per capita.

The White House report, dated Aug. 16, recommends several steps to curb the virus that Kemp has declined to take, including closing bars and issuing mask mandates in counties with 50 or more active cases.

Kemp was among the first governors to ease earlier restrictions this spring, and while infections declined for weeks afterwards, they began to rise in June and peaked in late July.

First reported by the Atlanta Journal-Constitution, the report says Georgias small gains are fragile and statewide progress will require continued, expanded, and stronger mitigation efforts, including in all open schools.

Kemp insisted Wednesday that other markers hes watching paint a different picture.

Associated Press

Puerto Ricos governor announced Wednesday that she will place the U.S. territory on a 24-hour lockdown every Sunday as part of stricter measures to fight a spike in coronavirus cases.

Gyms, theaters and bars will remain closed and only restaurants with outdoor areas will be allowed to seat people, but at 25% capacity. Gov. Wanda Vzquez said violators will be shut down for a month.

In addition, beaches will remain open only to those doing exercise such as runners and surfers, and businesses, malls and banks will be allowed to operate at only 25% capacity.

The new measures go into effect Saturday and will remain in place until Sept. 11. Face masks remain mandatory.

We have to adjust to living in a new reality, Vzquez said, blaming the jump in cases on careless people.

Associated Press

Cheerleaders and mascots will not be allowed to be on the field during NFL games this season.

The league-wide policy was part of new protocols unveiled Wednesday in conjunction with the NFL Players Association, a person familiar with the decision told USA TODAY Sports' Jarrett Bell. The person spoke on condition of anonymity because they were not authorized to speak publicly on the matter.

Previously, some of these decisions were being left to individual teams.

Sideline reporters and pregame panelists also will not be allowed on the field level, per the agreement.

Michael Middlehurst-Schwartz

A new study casts doubt on whether a virus can be transmitted by breast milk.

The study found only one of 64 samples of breast milk from 18 women in the U.S. who had become infected with the virustested positive. Further tests found that the virus couldn't replicate, making it unable to potentially infect a breast-fed infant.

The study by was conducted jointly by researchers at the University of California campuses in San Diego and Los Angeles and the results were published Wednesday in the online edition of the medical journal JAMA.

We hope our results and future studies will give women the reassurance needed for them to breastfeed. Human milk provides invaluable benefits to mom and baby, said Dr. Grace Aldrovandi, co-principal investigator of the study and chief of the Division of Infectious Diseases at UCLA Mattel Childrens Hospital.

Chinese government officials were involved in a coverup about the coronavirus, but not at the national level, says a U.S. intelligence report obtained by the New York Times.

Officials in the Wuhan and Hubei provinces in central China, where the virus first appeared, attempted to keep China's central leadership in Beijing from knowing key information about the early outbreak, concludes the report compiled by several U.S. intelligence agencies, including the CIA. Local officials feared reprisal from the central government.

The report, prepared in June with a mix of classified and unclassified data, backs the overall view that Communist Party officials hid important information from the World Heath Organization even as they sought to get details on the outbreak themselves from recalcitrant local officials.

President Donald Trump has repeatedly accused China of a coverup, alleging the virus could have been stopped much faster if it had been more forthcoming.

Deaths in Florida from the coronavirus surpassed 10,000, while teachers and state officials argued in court over whether in-person schools should reopen this month.

Florida reported 174 deaths on Wednesday, bringing the total confirmed deaths to at least 10,067 the fifth-highest death toll in the nation. The state reported an additional 4,115 confirmed coronavirus cases, bringing the total to 584,047. The positivity rate for coronavirus testing in Florida has averaged about 11.4% during the past week.

There were 5,351 patients being treated for the disease in Florida hospitals on Wednesday, down from peaks above 9,500 patients in late July.

Meanwhile, Floridas largest teachers union is seeking an injunction from a judge in Tallahassee to stop schools from reopening by this Friday.

Associated Press

Dreamed of actually snagging tickets to screenings at a major film festival? Because of the coronavirus pandemic, you make be able to see the films from your living room.

The festivals are where critics and insiders get early peeks at movies either slated for theaters or those hoping to receive the kind of breakout attention that will get them there. Because of the virus, the festivals have gone virtual streamed to living rooms.

The New York Film Festival is kicking off Sept. 25 with an opening night featuring Steve McQueens Lovers Rock, and will premiere two other of the Black filmmakers works, Mangrove and Red, White and Blue, part of the same anthology. Also on tap: Chloe Zhaos anticipated Nomadland with Frances McDormand, Sam Pollards documentary MLK/FBI, and the documentary Time, about a woman trying to get her husband released from his 60-year prison sentence.

Jeff Friday, founder of the American Black Film Festival, which runs through Aug. 30, has already seen the positives of making the move to virtual. Usually, 10,000 film fans show up for his annual June event in Miami; this year, he's predicting 200,000 people interested in streaming more than 90 films celebrating Black cinema, as well as panel discussions featuring Oscar-winning filmmaker Barry Jenkins, Candyman director Nia DaCosta, Mary J. Blige, Lena Waithe and Gabrielle Union.

Brian Truitt

Bars that cater to members of the LGBTQ community are not just bars: they serve as community hubs and safe spaces for lesbian, gay, bisexual, transgender and queer folks.So when they had to shut down due to the coronavirus pandemic in mid-March, those spaces were lost. Fighting back, some have launched crowdfunding campaigns to stay afloat until they are full back in business.

The owner of Harlem's Alibi Lounge, one of the only Black-owned LGBTQ bars in New York City, unveiled a campaign in May that has raised more than $166,000 and counting.

Julius Bar part of the National Register of Historic Places, the oldest gay bar in New York City and one of the oldest continually operating bars in the city overall has raised more than $97,000 via a GoFundMe campaign since early July.Its Greenwich Village neighbor, the Stonewall Inn, has raised more than $320,000 on the platform.

When, all of a sudden, a pandemic like COVID-19 tells you that you have to isolate, that you have to stay home and if you go to a bar, you go to a restaurant, you could be at a high risk to be exposed to the virus, it makes people not even think twice," said Alibi Lounge owner Alexi Minko. "They decide, Well, in that case I am not going to a bar, Im not going to a restaurant until I know that its safer.

Alex Biese, Asbury Park Press

Many furloughed workers were not being immediately called to report back to duty, a new study finds.In an analysis of its small business clients, payroll service Gusto found that only 37% of workers who were initially furloughed in March and 47% of those who were furloughed in April had returned to their jobs by July. Furthermore, among those furloughed in March who were able to go back to work, nearly 25% had their wages reduced.

Furloughed workers are counted as unemployed when determining the jobless rate, which means the fate of those still in limbo could drive unemployment up or down in the coming months.

Since April, the jobless rate has slowly declined, but if a large number of furloughed workers are able to return to their employers, we could see those numbers drop even more. That would spell good news for an economy that's stuck in a recession. On the other hand, a large chunk of furloughed workers could be permanently laid off in the coming months, too.

Maurie Backman, The Motley Fool

Pharmacists in all 50 states are now allowed to give childhood vaccinations under a new directive aimed at preventing future outbreaks of measles and other preventable diseases.

Alex Azar, the head of the U.S. Department of Health and Human Services, took the step using emergency powers he has during the coronavirus epidemic, which was declared a public health emergency.The directive announced Wednesday will temporarily preempt restrictions in 22 states starting this fall.

The move is designed to help prevent vaccination rates from falling during the pandemic, Azar said.

Separately, Massachusetts officials announced Wednesday that they will require flu vaccinations for all students, from child care to college. The vaccinations are required by Dec.31. Home-schooled students and those who are studying entirely remotely are exempted.

Associated Press

The New York Police Department announced its created a task force specifically to deal with a rise in hate crimes against Asian Americans during the coronavirus pandemic.

There have been 21 reported anti-Asian hate crimes leading to 17 arrests since March around the time the pandemic intensified in the United States, whichChief of Detectives Rodney Harrison told reporters is higher than normal Tuesday.

"Thisincrease was cultivated due to the anti-Asian rhetoric about the virus that was publicized and individuals began to attack Asian New Yorkers either verbal attack or physical assault," Harrison said. "We saw a spike in every borough throughout the city."

N'dea Yancey-Bragg

A patron who spent hours inside a bar during the Sturgis motorcycle rally in South Dakota, which ended last Sunday, has tested positive for COVID-19, health officials confirmed.

The person spent nearly six hours atOne-Eyed Jacks Saloon on Aug. 11. State officials are encouraging anyone at the bar to monitor themselves for any symptoms of the coronavirus.

The 2020 Rally drew more than 460,000 vehicles during the 10-day event, according to a count South Dakota transportation officials released Tuesday. The event was scaled down, but face coverings were not required during the event.

Michael Klinski, Sioux Falls Argus Leader

Pope Francis on Wednesday cautioned against prioritizing future coronavirus vaccines based on wealth. Deviating fromhis plannedweekly public address, he said that "we must come out better" from the COVID-19 pandemic.

How sad it would be if for the COVID-19 vaccine priority is given to the richest," he said. The pandemic has laid bare the difficult situation of the poor and the great inequality that reigns in the world."

The pontiff added that the vaccine should be "universal and for all," rather than "the property of this nation or another," not naming any countries in particular.

At least two dozen Maine residents tested positive for COVID-19 after a wedding reception in rural Maine the states first outbreak linked to a social gathering.

About 65 people attended theindoor event at the Big Moose Inn in Millinocket, said Maine CDC spokesman Robert Long. About 18 people in attendance and around 10others who came into contact with attendees all tested positive, according to WABI-TV in Bangor, Maine.

The owner of the Big Moose Inn could face a $10,000 fine if the state's executive orders limiting group gatherings to 50 were violated, officials said.

R-0 may be the most important scientific term youve never heard of when it comes to stopping the coronavirus pandemic. USA TODAY

During the pandemic, people are talking a lot about children missing classes, graduations and proms. What has received far less attention, child development experts say, is the impact the pandemic is having on the youngest children: babies, toddlers, preschoolers, kindergartners.

Birth to age five is a critical time for child development, research shows, and new data from the Rapid Assessment of Pandemic Impact on Development Early Childhood Household Survey Project (RAPID-EC Project) shows caregiver distress is cascading down to young children in ways science shows can be toxic in the short- and long-term.

The project has been conducting weekly surveys since April and has found caregivers of young children are experiencing distress, material hardship and loss of emotional supports. Since the project's data is sequential, it also is able to show a chain reaction. When a family is stressed about meeting basic needs, the next week they report more emotional distress, and the week after report increases in their child's emotional distress.

"if you can't buy food or you can't pay your rent, that you are experiencing the kind of stress that is going to be toxic to your children,"said RAPID project director Phil Fisher.

Alia E. Dastagir

Nearly 80 teachers in Utah's Salt Lake County have resigned or retired as in-person classes are set to resume at schools this year, the Salt Late Tribune reported.

The Tribune tallied 79 teachers who left their posts due to concerns about COVID-19. At least 16 of the resignations came in the last week, the newspaper reported.

Salt Lake County has the highest number of virus cases in the state, and teachers leaving the classroom told the newspaper that they'd rather resign or retire now than return in the fall, risking their own health or the health of their students.

Were just being told to jump in like nothing is wrong, Jan Roberts, a teacher of32 years who just retired, told the Tribune. Its not OK.

Health officials have identified a COVID-19 cluster at another North Carolina university.

A statement from North Carolina State University confirmed on Tuesday that Wake County health officials identified of COVID-19 cases at off-campus housing east of the Raleigh, North Carolina, campus.

The school said several people who have tested positive as part of this cluster have been identified, including some who are N.C. State students. Contact tracing has been initiated with direct communication to anyone known to have been in close contact with a person who has tested positive for COVID-19, according to the school.

The school said reports indicated a party or some type of gathering was hosted at the location on or around Aug. 6. The notice said it was not known how many people were at the gathering, but encouraged anyone who attended to visit their personal healthcare provider or Student Health Services.

Switching from in-person to online schooling has been hard on many families and on their budgets.

About one-quarter of parents say theyve gone into debt to pay for their kids at-home school expenses, and many blame the cost of their kids breakfasts and lunches when they switched to learning remotely from home.

A survey from Credit Karma examines how this school year could affect household finances. More than half of parents say they expect to spend slightly to significantly more on school supplies, the survey of more than 1,000 parents found.

The reasons for the debt are higher grocery prices and the sudden switch to at-home schooling in March.

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Coronavirus updates: University of North Carolina temporarily suspends fall sports; Pope warns against the rich getting vaccine first - USA TODAY

Faster test results and ‘robust’ immune response may offer hope of curbing the pandemic, experts say – CNN

Tests have been delayed and in short supply as the United States surpassed 5.4 million cases, leaving many uncertain about their risk of spreading the virus. And as researchers rush to develop vaccines, they've had little evidence to tell if antibodies that protect against Covid-19 last long enough to get the virus under control. But developments from researchers Monday brought optimistic outlooks to both fronts.

SalivaDirect, a test that does not require specialized supplies and can deliver results in less than three hours, could be available to the public in a matter of weeks, according to Anne Wyllie, an epidemiologist at Yale School of Public Health who was part of the team responsible for the protocol.

"It skips so many steps up front, so it makes it much more amenable to be used as a surveillance tool like in schools or universities," Dr. Brett Giroir, the White House coronavirus testing coordinator, told ABC's "Good Morning America" on Tuesday.

And though many are in early stages and have not been peer-reviewed, a recent batch of studies show that humans -- even those with mild symptoms -- have a "robust" immune response to coronavirus that could provide evidence that a vaccine could protect the public for more than just a short period of time, said Dr. Ian Lipkin, director of the Center for Infection and Immunity at Columbia University Mailman School of Public Health.

"This is very good news and it's optimistic," Lipkin said Monday. "You know, it is a bit of blue sky that we've been looking for."

How long that protection lasts is still unclear, but the studies indicate it could last for months.

The outbreaks at universities continue

Campus life is returning to full swing as college students come back to school -- and now several universities are reporting coronavirus outbreaks.

Add North Carolina State University, where there are two clusters of cases, to the list of schools with outbreaks on or near campus.

Eight members of the Greek Life system have tested positive for Covid-19, school spokeswoman Lauren Barker said in a statement.

Those students live in chapter houses that are either university-owned or privately owned.

Officials at the school said they were also notified by the Wake County Health Department of another cluster at an off-campus housing facility. The health department said reports indicated there was a gathering there August 6.

As part of the university's contact tracing program, close contacts have been advised to quarantine for 14 days, which in some cases could mean the entire house being quarantined, Barker said.

The university announced Tuesday that undergraduate students will shift to online classes for the next two weeks.

"We have seen a dramatic increase in the number of positive cases of Covid-19 in your first weeks back on campus," the Rev. John I. Jenkins, university president, said. "The spike in cases is very serious. And we must take serious steps to address it."

Analysis from contact tracers has shown that most infections have been the result of off campus gatherings, Jenkins said.

Some K-12 school districts are seeing outbreaks too.

In Florida, more than 25 districts are due to have started in-person instruction by week's end. Three districts -- in Baker, Bradford and Martin counties -- reported having to place students in quarantine after a week of in-person classes. Martin County alone has quarantined 321 students, district spokeswoman Jennifer DeShazo said Tuesday.

The school district -- the country's second-largest with more than 600,000 students -- is beginning the new school year without in-person classes. The hope, Superintendent Austin Beutner told CNN Tuesday, is to build a foundation for when the district opens for in-person learning.

"If we want to keep schools from becoming a petri dish and we want to keep all in the school community safe, we need to test and trace at schools," he said.

Study: No apparent racial difference in Covid-19 death rates if there's equal access to health care

The research found no difference in mortality among Black and White patients hospitalized for coronavirus infection, after adjusting for sociodemographic and clinical factors.

Dr. Baligh Yehia of Ascension Health in Missouri and colleagues studied 11,210 adult coronavirus patients between February and May in 92 hospitals across 12 states. They found no statistical difference in the risk of mortality between White and Black patients, after adjusting for age, sex, insurance status, comorbidity, neighborhood deprivation and site of care.

Of the 11,210 patients, 37.3% were Black. Black patients were younger, more likely to be women and more likely to have Medicaid insurance than their White counterparts. Black patients were also more likely to have other health conditions such as asthma, cancer, chronic kidney disease, congestive heart failure, diabetes, hypertension and obesity.

About 63.7% of patients were hospitalized and 39.4% were Black. After adjusting for outside factors, the team found that mortality was 19.2% among Black patients and 23.1% among White patients. The overall mortality rate was 20.3%.

Similar rates of Black and White patients needed an intensive care unit. Among those in the ICU, 35.2% of Black patients died and 36.4% of White patients died.

"Although current reports suggest that Black patients represent a disproportionate share of COVID-19 infections and death in the United States, in this study, mortality for those able to access hospital care did not differ between Black and White patients after adjusting for sociodemographic factors and comorbidities."

They called for additional research on coronavirus mortality by race.

CNN's Annie Grayer, Jamiel Lynch, Artemis Moshtaghian, Topher-Gauk Roger, Amanda Watts, Lauren Mascarenhas, Jason Hanna, Eric Levenson, Naomi Thomas and Jen Christensen contributed to this report.

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Faster test results and 'robust' immune response may offer hope of curbing the pandemic, experts say - CNN