Could Bee Venom Be the Key to Treating Triple-Negative Breast Cancer? – BioSpace

A study published in the journal npj Precision Oncology on Sept. 1 featured data that suggested honeybee venom can potentially destroy triple-negative breast cancer and HER2-enriched breast cancer cells.

Dr. Ciara Duffy from the Harry Perkins Institute of Medical Research and The University of Western Australia led the research. She and her colleagues tested the effect of venom on clinical subtypes of breast cancer, using the venom from 312 honeybees and bumblebees from Perth Western Australia, Ireland and England.

"No one had previously compared the effects of honeybee venom or melittin across all of the different subtypes of breast cancer and normal cells, Dr. Duffy said. "We tested honeybee venom on normal breast cells, and cells from the clinical subtypes of breast cancer: hormone receptor positive, HER2-enriched, and triple-negative breast cancer.

Dr. Duffy explained that the goal of the research was ultimately to determine if honeybee venom and its component compound, melittin, had anti-cancer properties.

"We found both honeybee venom and melittin significantly, selectively and rapidly reduced the viability of triple-negative breast cancer and HER2-enriched breast cancer cells, said Dr. Duffy. "The venom was extremely potent."

Melittin, in particular, also had a surprising effect. Within 20 minutes, the compound was able to reduce the chemical messages of cancer cells that are necessary for growth and cell division.

"We looked at how honeybee venom and melittin affect the cancer signaling pathways, the chemical messages that are fundamental for cancer cell growth and reproduction, and we found that very quickly these signaling pathways were shut down, said Dr. Duffy. "Melittin modulated the signaling in breast cancer cells by suppressing the activation of the receptor that is commonly overexpressed in triple-negative breast cancer, the epidermal growth factor receptor, and it suppressed the activation of HER2 which is over-expressed in HER2-enriched breast cancer.

Western Australia's Chief Scientist Professor Peter Klinken noted that this study significantly demonstrates the potential benefits of melittin, and overall, how compounds in nature can be utilized to combat human diseases.

The researchers note that studies will be necessary to formally assess the best way to deliver melittin to patients.

This is not the only positive news that has come out of the breast cancer treatment realm as of late. Athenex also announced on Sept. 1 that the U.S. Food and Drug Administration (FDA) had accepted its New Drug Application for oral paclitaxel and encequidar for the treatment of metastatic breast cancer, and it has been granted Priority Review.

We see oral paclitaxel as a potentially important alternative to IV infusions, especially during the current pandemic, as it may allow cancer patients to take the oral chemotherapy at home, said Dr. Johnson Lau, Chairman and Chief Executive Officer of Athenex. We believe the oral paclitaxel program validates our broader Orascovery platform, and we are committed to applying the technology to convert other IV chemotherapies into oral agents.

The NDA is based on data from a Phase 3 study of oral paclitaxel for the treatment of metastatic breast cancer. The trial was randomized and controlled, and looked at the safety and efficacy of oral paclitaxel monotherapy against IV paclitaxel monotherapy. It achieved its primary endpoint, demonstrating a statistically significant improvement in overall response rate, along with a lower neuropathy, compared to IV paclitaxel.

The FDA grants Priority Review to NDAs for potential drugs that, if approved, would make significant improvements to the way patients are treated for serious conditions, such as various types of cancer.

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Could Bee Venom Be the Key to Treating Triple-Negative Breast Cancer? - BioSpace

AB Science: New independent research reveals that masitinib has direct anti-viral activity against the SARS-CoV-2 virus in vitro and is a promising…

Paris, 02 September 2020, 8.15pm

New independent research reveals that masitinib has direct anti-viral activity against the SARS-CoV-2 virus in vitro and is a promising candidate for treating COVID-19

AB Science SA (NYSE Euronext - FR0010557264 - AB) today announced the publication of preclinical study results with masitinib in COVID-19. Research led by scientists from the University of Chicago has been posted on the bioRxiv preprint service as an article entitled, Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. The article [1] is freely accessible online from the bioRxiv site https://www.biorxiv.org/content/10.1101/2020.08.31.274639v1

This article reports results of an independent study led by Professor Savas Tay from the Pritzker School for Molecular Engineering (University of Chicago, USA). Starting from a library of 1,900 clinically used drugs, either approved for human use or in late stage clinical development, masitinib stood-out in its ability to completely inhibit activity of the SARS-CoV-2 main protease (3CLpro), thereby blocking viral replication. Remarkably, the research team elucidated masitinibs mechanism of action against SARS-CoV-2, showing that masitinib inhibits 3CLpro, SARS-CoV-2 protease that is crucial for virus infection and reproduction, by directly binding to the protease catalytic site.

This research has shown for the first time that masitinib exerts a direct anti-viral effect on the SARS-CoV-2 virus, under in vitro conditions. Considering these data in conjunction with masitinibs possible action against life-threatening complications arising from COVID-19 related cytokine storm, suggests that it could be an effective treatment of COVID-19. As such, the clinical development program of masitinib in COVID-19, which includes to date one ongoing phase 2 study, is given a new impetus to determine masitinibs potential to treat COVID-19, said Dr Nir Drayman, senior researcher at the Pritzker School for Molecular Engineering (University of Chicago) and one of the articles principal authors.

Masitinibs dual anti-viral and anti-inflammatory action is a highly attractive approach for combatting severe COVID-19 infections and is one that sets this compound apart from the majority of other drugs currently under development to treat COVID-19, said Professor Savas Tay, principal investigator of the study and author of the article (Pritzker School for Molecular Engineering, University of Chicago).

These data identify a novel mechanism of action by which masitinib could exert an anti-viral effect against viral diseases by targeting virus protease. In particular, results provide a new compelling biological rationale for the use of masitinib in the treatment of COVID-19. Positive results from masitinibs development in severe uncontrolled asthma also provide a good indication that masitinib could be beneficial in the treatment of respiratory disorders such as COVID-19. Taken together, these data highlight the importance of conducting clinical studies with masitinib in COVID-19, commented Olivier Hermine (President of the Scientific Committee of AB Science and member of the Acadmie des Sciences in France).

Masitinib recently received authorization by the French Medicine Agency (ANSM) to initiate a Phase 2 study evaluating masitinib in combination with isoquercetin for the treatment of COVID-19 [2]. This study (AB20001) is a randomized (1:1), open-label Phase 2 clinical trial to evaluate the safety and efficacy of masitinib combined with isoquercetin in hospitalized patients with moderate and severe COVID-19. The study will enroll 200 patients (age 18 without an upper age limit) at medical centers in France and other countries. The primary objective is to improve the clinical status of patients after 15 days of treatment.

[1] Drayman N, Jones KA, Azizi S-A, et al. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639

[2] AB Science press release. May 06,2020. http://www.ab-science.com/years/2020/

About bioRxivbioRxiv (pronounced "bio-archive") is a free online archive and distribution service for unpublished preprints in the life sciences. It is operated by Cold Spring Harbor Laboratory, a not-for-profit research and educational institution. By posting preprints on bioRxiv, authors are able to make their findings immediately available to the scientific community and receive feedback on draft manuscripts before they are submitted to journals.

About masitinibMasitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. Through its activity on mast cells and microglia and consequently the inhibition of the activation of the inflammatory process, masitinib can have an effect on the symptoms associated with some inflammatory and central nervous system diseases and the degeneration of these diseases.

About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Companys lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB).

Further information is available on AB Sciences website: http://www.ab-science.com.

Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance.

These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science with the Autorit des Marchs Financiers (AMF), including those listed in the Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligationor undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations.

For additional information, please contact:

AB ScienceFinancial Communication & Media Relations investors@ab-science.com

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Pregnant women with coronavirus are more likely to need intensive care and give birth early, finds study – MEAWW

Pregnant women are thought to be a high-risk group for Covid-19 infection and there are concerns about potential adverse effects of the virus on both mother and baby. However, published reviews on Covid-19 in pregnancy quickly become outdated as new evidence emerges. A new study now helps to shed light on the risks of Covid-19 for pregnant women and their babies.

An international team of researchers has found that pregnant women seen at the hospital with suspected or confirmed Covid-19 are less likely to have fever or muscle pain and symptoms of the disease, but seem to be at an increased risk of needing intensive care than non-pregnant women of similar age.

The findings also reveal that pregnant or recently pregnant women with Covid-19 are more likely to give birth prematurely and their newborns are more likely to be admitted to a neonatal unit. Researchers found that 1 in 4 of all babies born to women with Covid-19 were admitted to a neonatal unit, but data on causes of preterm births or indications for admission to neonatal units among these babies are lacking. Stillbirth and newborn death rates, however, are low.

"We found that one in 10 pregnant or recently pregnant women who are attending or admitted to hospital for any reason are diagnosed as having suspected or confirmed Covid-19, although the rates vary by sampling strategy. The Covid-19 related symptoms of fever and myalgia (muscle pain) manifest less often in pregnant and recently pregnant women than in non-pregnant women of reproductive age. Whereas testing for SARS-CoV-2 (the virus that causes Covid-19) in non-pregnant women is based on symptoms or contact history, testing in pregnant women is usually done when they are in hospital for reasons that might not be related to Covid-19," write the authors in the study published in BMJ.

The paper is a living systematic review that compares the clinical features, risk factors and outcomes of Covid-19 in pregnant and recently pregnant women with non-pregnant women of similar age. It has been led by experts at the University of Birmingham, UK, the World Health Organization (WHO), the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), and other collaborators. Living systematic reviews are useful in fast-moving research areas such as Covid-19 because they can be updated regularly as new information becomes available.

"With the establishment of several national and global prospective cohorts, we expect the sample size of our meta-analysis to increase further in the coming months. Our living systematic review and metaanalysis, with its regular search and analyses updates, is ideally placed to assess the impact of new findings on the rapidly growing evidence base," the researchers emphasize.

Dr Edward Morris, president of the Royal College of Obstetricians and Gynaecologists, who was not involved in the study, says that while overall risks to pregnant women from coronavirus are low, the findings of this study highlight the particular risks to pregnant women, especially those in the third trimester of pregnancy, should they become unwell with coronavirus. "Pregnant women are included in the list of people at moderate risk as a precaution and pregnant women should, therefore, continue to follow the latest government guidance on social distancing and avoiding anyone with symptoms suggestive of coronavirus," he suggests.

The report is based on 77 studies reporting rates, clinical features (symptoms, laboratory and X-ray findings), risk factors and outcomes for 11,432 pregnant and recently pregnant women admitted to the hospital and diagnosed as having suspected or confirmed Covid-19. The studies were designed differently and were of varying quality, but experts were able to allow for that in their analysis.

Compared with non-pregnant women of reproductive age, the investigators found that pregnant and recently pregnant women with Covid-19 were less likely to report symptoms of fever and muscle pain, but they were more likely to need admission to an intensive care unit and invasive ventilation. The odds of giving birth prematurely was also higher in pregnant and recently pregnant women with Covid-19 compared to those without the disease. A quarter of all babies born to mothers with Covid-19 were admitted to a neonatal unit and were at increased risk of admission than those born to mothers without the disease.

Marian Knight, professor of maternal and child population health, Nuffield Department of Population Health, University of Oxford, who was not involved in the study, emphasizes that reviews such as this can only be as good as the studies they summarise and it is important to note that a high proportion of the included studies have a substantial risk of bias.

"It is also important to recognize that, while this review reports high preterm birth rates, a number of women affected by Covid-19 in pregnancy are still pregnant, and thus are not included in the study data. This may make preterm birth rates appear artificially high. Preterm birth rates are likely to be lower once all women have given birth and their information is included. Nevertheless, some pregnant women affected by Covid-19 may have a subsequent preterm birth, and preventing infection remains essential. Pregnant women should thus continue to pay attention to hand washing and social distancing measures to reduce their risk of coronavirus," recommends Knight.

Evidence currently suggests that people who are non-White, are older, who are overweight and/or have a pre-existing medical condition, are more vulnerable to severe disease due to Covid-19. According to the new findings, pregnant women with Covid-19, who have pre-existing medical conditions, such as diabetes or chronic high blood pressure, or those who are older or overweight, are also more likely to suffer severe health complications due to coronavirus.

"Maternal risk factors associated with severe Covid-19 were increasing age, high body mass index, chronic high blood pressure, and pre-existing diabetes. Pre-existing maternal comorbidity was associated with admission to an intensive care unit and the need for invasive ventilation. These findings underline the need for pregnant women and recently pregnant women to take all precautions to avoid COVID-19 disease, in particular, if they have underlying conditions, says the team.

Researchers point to some study limitations that may have affected their results, including differences in study size, design, and definitions of symptoms, tests and outcomes. However, strengths include the large sample size and robust search methods to minimize the risk of missing studies and duplicate data, they explain.

According to the researchers, healthcare professionals should be aware that pregnant women with Covid-19 and their newborn babies might need access to intensive care and specialist baby care facilities. This is particularly true for pregnant women with Covid-19 alongside other underlying medical conditions. The experts suggest that mothers with pre-existing comorbidities will need to be considered as a high-risk group for Covid-19, along with those who are obese and of older age.

"Clinicians will need to balance the need for regular multidisciplinary antenatal care to manage women with pre-existing comorbidities against unnecessary exposure to the virus, through virtual clinic appointments when possible. Pregnant women with Covid-19 before term gestation might need to be managed in a unit with facilities to care for preterm neonates," the findings state.

The team believes it is crucial to stress that whether or not a woman has Covid-19, her right to a positive pregnancy and childbirth experience must be ensured. "It is also important to recognize the increased stress and anxiety caused by Covid-19, which may be particularly felt by pregnant women, recently-pregnant women, and their partners, children, and families; healthcare providers have a role in responding to pregnant women in an appropriate and compassionate way," suggest authors.

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Pregnant women with coronavirus are more likely to need intensive care and give birth early, finds study - MEAWW

The Renewal of the Socialist Ideal – Monthly Review

John Bellamy Foster is editor of Monthly Review and a professor of sociology at the University of Oregon.

This article is a revised and extended version of a talk presented on July 12, 2020, to the concluding session (of the Main Forum) of the Seventh South-South Forum on Sustainability: Climate Change, Global Crises, and Community Regeneration. The Conference/Webinar was organized by Lau Kin Chi and Sit Tsui through Lingnan University in Hong Kong.

Any serious treatment of the renewal of socialism today must begin with capitalisms creative destruction of the bases of all social existence. Since the late 1980s, the world has been engulfed in an epoch of catastrophe capitalism, defined as the accumulation of imminent catastrophe on every side due to the unintended consequences of the juggernaut of capital.1 Catastrophe capitalism in this sense is manifested today in the convergence of (1) the planetary ecological crisis, (2) the global epidemiological crisis, and (3) the unending world economic crisis.2 Added to this are the main features of todays empire of chaos, including the extreme system of imperialist exploitation unleashed by global commodity chains; the demise of the relatively stable liberal-democratic state with the rise of neoliberalism and neofascism; and the emergence of a new age of global hegemonic instability accompanied by increased dangers of unlimited war.3

The climate crisis represents what the world scientific consensus refers to as a no analogue situation, such that if net carbon emissions from fossil fuel combustion do not reach zero in the next few decades, it will threaten the very existence of industrial civilization and ultimately human survival.4 Nevertheless, the existential crisis is not limited to climate change, but extends to the crossing of other planetary boundaries that together define the global ecological rift in the Earth System as a safe place for humanity. These include: (1) ocean acidification; (2) species extinction (and loss of genetic diversity); (3) destruction of forest ecosystems; (4) loss of fresh water; (5) disruption of the nitrogen and phosphorus cycles; (6) the rapid spread of toxic agents (including radionuclides); and (7) the uncontrolled proliferation of genetically modified organisms.5

This rupturing of planetary boundaries is intrinsic to the system of capital accumulation that recognizes no insurmountable barriers to its unlimited, exponential quantitative advance. Hence, there is no exit from the current capitalist destruction of the overall social and natural conditions of existence that does not require exiting capitalism itself. What is essential is the creation of what Istvn Mszros in Beyond Capital called a new system of social metabolic reproduction.6 This points to socialism as the heir apparent to capitalism in the twenty-first century, but conceived in ways that critically challenge the theory and practice of socialism as it existed in the twentieth century.

In the United States, key sectors of monopoly-finance capital have now succeeded in mobilizing elements of the primarily white lower-middle class in the form of a nationalist, racist, misogynist ideology. The result is a nascent neofascist political-class formation, capitalizing on the long history of structural racism arising out of the legacies of slavery, settler colonialism, and global militarism/imperialism. This burgeoning neofascisms relation to the already existing neoliberal political formation is that of enemy brothers characterized by a fierce jockeying for power coupled with a common repression of the working class.7 It is these conditions that have formed the basis of the rise of the New York real-estate mogul and billionaire Donald Trump as the leader of the so-called radical right, leading to the imposition of right-wing policies and a new authoritarian capitalist regime.8 Even if the neoliberal faction of the ruling class wins out in the coming presidential election, ousting Trump and replacing him with Joe Biden, a neoliberal-neofascist alliance, reflecting the internal necessity of the capitalist class, will likely continue to form the basis of state power under monopoly-finance capital.

Appearing simultaneously with this new reactionary political formation in the United States is a resurgent movement for socialism, based in the working-class majority and dissident intellectuals. The demise of U.S. hegemony within the world economy, accelerated by the globalization of production, has undermined the former, imperial-based labor aristocracy among certain privileged sections of the working class, leading to a resurgence of socialism.9 Confronted with what Michael D. Yates has called the Great Inequality, the mass of the population in the United States, particularly youth, are faced with rapidly diminishing prospects, finding themselves in a state of uncertainty and often despair, marked by a dramatic increase in deaths of despair.10 They are increasingly alienated from a capitalist system that offers them no hope and are attracted to socialism as the only genuine alternative.11 Although the U.S. situation is unique, similar objective forces propelling a resurgence of socialist movements are occurring elsewhere in the system, primarily in the Global South, in an era of continuing economic stagnation, financialization, and universal ecological decline.

But if socialism is seemingly on the rise again in the context of the structural crisis of capital and increased class polarization, the question is: What kind of socialism? In what ways does socialism for the twenty-first century differ from socialism of the twentieth century? Much of what is being referred to as socialism in the United States and elsewhere is of the social-democratic variety, seeking an alliance with left-liberals and thus the existing order, in a vain attempt to make capitalism work better through the promotion of social regulation and social welfare in direct opposition to neoliberalism, but at a time when neoliberalism is itself giving way to neofascism.12 Such movements are bound to fail at the outset in the present historical context, inevitably betraying the hopes that they unleashed, since focused on mere electoral democracy. Fortunately, we are also seeing the growth today of a genuine socialism, evident in extra-electoral struggle, heightened mass action, and the call to go beyond the parameters of the present system so as to reconstitute society as whole.

The general unrest latent at the base of U.S. society was manifested in the uprisings in late May and June of this year, which took the form, practically unheard of in U.S. history since the U.S. Civil War, of massive solidarity protests with millions of people in the streets, and with the white working class, and white youth in particular, crossing the color line en masse in response to the police lynching of George Floyd for no other crime than being a Black man.13 This event, coming in the midst of the COVID-19 pandemic and the related economic depression, led to the June days of rage in the United States.

But while the movement toward socialism, now taking hold even in the United States at the barbaric heart of the system, is gaining ground as a result of objective forces, it lacks an adequate subjective basis.14 A major obstacle in formulating strategic goals of socialism in the world today has to do with twentieth-century socialisms abandonment of its own ideals as originally articulated in Karl Marxs vision of communism. To understand this problem, it is necessary to go beyond recent left attempts to address the meaning of communism on a philosophical basis, a question that has led in the last decade to abstract treatments of The Communist Idea, The Communist Hypothesis, and The Communist Horizon by Alain Badiou and others.15 Rather, a more concrete historically based starting point is necessary, focusing directly on the two-phase theory of socialist/communist development that emerged out of Marxs Critique of the Gotha Programme and V. I. Lenins The State and Revolution. Paul M. Sweezys article Communism as an Ideal, published more than half a century ago in Monthly Review in October 1963, is now a classic text in this regard.16

In The Critique of the Gotha Programmewritten in opposition to the economistic and laborist notions of the branch of German Social Democracy influenced by Ferdinand LassalleMarx designated two historical phases in the struggle to create a society of associated producers. The first phase was initiated by the revolutionary dictatorship of the proletariat, reflecting the class-war experience of the Paris Commune and representing a period of workers democracy, but one that still carried the defects of capitalist class society. In this initial phase, not only would a break with capitalist private property take place, but also a break with the capitalist state as the political command structure of capitalism.17 As a measure of the limited nature of socialist transition in this stage, production and distribution would inevitably take the form of to each according to ones labor, perpetuating conditions of inequality even while creating the conditions for their transcendence. In contrast, in the later phase, the principle governing society would shift to from each according to ones ability, to each according to ones need and the elimination of the wage system.18 Likewise, while the initial phase of socialism/communism would require the formation of a new political command structure in the revolutionary period, the goal in the higher phase was the withering away of the state as a separate apparatus standing above and in antagonistic relation to society, to be replaced with a form of political organization that Frederick Engels referred to as community, associated with a communally based form of production.19

In the later, higher phase of the transition of socialism/communism, not only would property be collectively owned and controlled, but the constitutive cells of society would be reconstituted on a communal basis and production would be in the hands of the associated producers. In these conditions, Marx stated, labor will have become not a mere means of life but itselfthe prime necessity of life.20 Production would be directed at use values rather than exchange values, in line with a society in which the free development of each would be the condition for the free development of all. The abolition of capitalist class society and the creation of a society of associated producers would lead to the end of class exploitation, along with the elimination of the divisions between mental and manual labor and between town and country. The monogamous, patriarchal family based on the domestic enslavement of women would also be surmounted.21 Fundamental to Marxs picture of the higher phase of the society of associated producers was a new social metabolism of humanity and the earth. In his most general statement on the material conditions governing the new society, he wrote: Freedom, in this sphere [the realm of natural necessity], can consist only in this, that socialized man, the associated producers, govern the human metabolism of nature in a rational wayaccomplishing it with the least expenditure of energy in the process of promoting conditions of sustainable human development.22

Writing in The State and Revolution and elsewhere, Lenin deftly captured Marxs arguments on the lower and higher phases, depicting these as the first and second phases of communism. Lenin went on to emphasize what he called the scientific distinction between socialism and communism, whereby what is usually called socialism was termed by Marx the first, or lower phase of communist society, whereas the term communism, meaning complete communism, was most appropriately used for the higher phase.23 Although Lenin closely aligned this distinction with Marxs analysis, in later official Marxism this came to be rigidified in terms of two entirely separate stages, with the so-called communist stage so removed from the stage of socialism that it became utopianized, no longer seen as part of a continuous or ongoing struggle. Based on a wooden conception of the socialist stage and the intermediary principle of distribution to each according to ones labor, Joseph Stalin carried out an ideological war against the ideal of real equality, which he characterized as a reactionary, petty-bourgeois absurdity worthy of a primitive sect of ascetics but not of a socialist society organized on Marxist lines. This same stance was to persist in the Soviet Union in one way or another all the way to Mikhail Gorbachev.24

Hence, as explained by Michael Lebowitz in The Socialist Imperative, rather than a continuous struggle to go beyond what Marx called the defects inherited from capitalist society, the standard interpretation of Marxism in the half-century from the late 1930s to the late 80s introduced a division of post-capitalist society into two distinct stages, determined economistically by the level of development of the productive forces. Fundamental changes in social relations emphasized by Marx as the very essence of the socialist path were abandoned in the process of living with and adapting to the defects carried over from capitalist society. Instead, Marx had insisted on a project aimed at building the community of associated producers from the outset as part of an ongoing, if necessarily uneven, process of socialist construction.25

This abandonment of the socialist ideal associated with Marxs higher phase of communism was wrapped up in a complex way with changing material (and class) conditions and eventually the demise of Soviet-type societies, which tended to stagnate once they ceased to be revolutionary and even resurrected class forms, heralding their eventual collapse as the new class or nomenklatura abandoned the system. As Sweezy argued in 1971, state ownership and planning are not enough to define a viable socialism, one immune to the threat of retrogression and capable of moving forward on the second leg of the movement to communism. Something more was needed: the continuous struggle to create a society of equals.26

For Marx, the movement toward a society of associated producers was the very essence of the socialist path embedded in communist consciousness.27 Yet, once socialism came to be defined in more restrictive, economistic terms, particularly in the Soviet Union from the late 1930s onward, in which substantial inequality was defended, post-revolutionary society lost the vital connection to the dual struggle for freedom and necessity, and hence became disconnected from the long-term goals of socialism from which it had formerly derived its meaning and coherence.

Based on this experience, it is evident that the only way to build socialism in the twenty-first century is to embrace precisely those aspects of the socialist/communist ideal that allow a theory and practice radical enough to address the urgent needs of the present, while also not losing sight of the needs of the future. If the planetary ecological crisis has taught us anything, it is that what is required is a new social metabolism with the earth, a society of ecological sustainability and substantive equality. This can be seen in the extraordinary achievements of Cuban ecology, as recently shown by Mauricio Betancourt in The Effect of Cuban Agroecology in Mitigating the Metabolic Rift in Global Environmental Change.28 This conforms to what Georg Lukcs called the necessary double transformation of human social relations and the human relations to nature.29 Such an emancipatory project must necessarily pass through various revolutionary phases, which cannot be predicted in advance. Yet, to be successful, a revolution must seek to make itself irreversible through the promotion of an organic system directed at genuine human needs, rooted in substantive equality and the rational regulation of the human social metabolism with nature.30

Building on G. W. F. Hegels philosophy, Engels famously argued in Anti-Dhring that real freedom was grounded in the recognition of necessity. Revolutionary change was the point at which freedom and necessity met in concrete praxis. Although there was such a thing as blind necessity beyond human knowledge, once objective forces were grasped, necessity was no longer blind, but rather offered new paths for human action and freedom. Necessity and freedom fed on each other, requiring new periods of social change and historical transcendence.31 In illustrating this materialist dialectical principle, Lenin acutely observed, we do not know the necessity of nature in the phenomena of the weather. But while we do not know this necessity, we do know that it exists.32 We know the human relation to the weather and nature in general inevitably varies with the changing productive relations governing our actions.

Today, the knowledge of anthropogenic climate crisis and of extreme weather events is removing human beings from the realm of blind necessity and demanding that the worlds population engage in the ultimate struggle for freedom and survival against catastrophe capitalism. As Marx stated in the context of the severe metabolic rift imposed on Ireland as a result of British colonialism in the nineteenth century, the ecological crisis presents itself as a case of ruin or revolution.33 In the Anthropocene, the ecological rift resulting from the expansion of the capitalist economy now exists on a scale rivaling the biogeochemical cycles of the planet. However, knowledge of these objective developments also allows us to conceive the necessary revolution in the social metabolic reproduction of humanity and the earth. Viewed in this context, Marxs crucial conception of a community of associated producers is not to be viewed as simply a far-off utopian conception or abstract ideal but as the very essence of the necessary human defense in the present and future, representing the insistent demand for a sustainable relation to the earth.34

But where is the agent of revolutionary change? The answer is that we are seeing the emergence of the material preconditions of what can be called a global environmental proletariat. Engelss Condition of the Working Class in England, published in 1845, was a description and analysis of working-class conditions in Manchester, shortly after the so-called Plug Plot Riots and at the height of radical Chartism. Engels depicted the working-class environment not simply in terms of factory conditions, but much more in terms of urban developments, housing, water supply, sanitation, food and nutrition, and child development. The focus was on the general epidemiological environment enforced by capitalism (what Engels called social murder and what Norman Bethune later called the second sickness) associated with widespread morbidity and mortality, particularly due to contagious disease.35 Marx, under the direct influence of Engels and as a result of his own social epidemiological studies twenty years later while writing Capital, was to see the metabolic rift as arising not only in relation to the degradation of the soil, but equally, as he put it, in terms of periodical epidemics induced by society itself.36

What this tells usand we could find many other illustrations, from the Russian and Chinese Revolutions to struggles in the Global South todayis that class struggle and revolutionary moments are the product of a coalescence of objective necessity and a demand for freedom emanating from material conditions that are not simply economic but also environmental in the broadest sense. Revolutionary situations are thus most likely to come about when a combination of economic and ecological conditions make social transformations necessary, and where social forces and relations are developed enough to make such changes possible. In this respect, looked at from a global standpoint today, the issue of the environmental proletariat overlaps with and is indistinguishable from the question of the ecological peasantry and the struggles of the Indigenous. Likewise, the struggle for environmental justice that now animates the environmental movement globally is in essence a working-class and peoples struggle.37

The environmental proletariat in this sense can be seen as emerging as a force all over the world, as evident in the present period of ecological-epidemiological struggle in relation to COVID-19. Yet, the main locus of revolutionary ecological action in the immediate future remains the Global South, faced with the harsh reality of imperialism in the Anthropocene.38 As Samir Amin observed in Modern Imperialism, Monopoly Finance Capital, and Marxs Law of Value, the triad of the United States, Europe, and Japan is already using the planets bio-capacity at four times the world average, pointing toward ecological oblivion. This unsustainable level of consumption of resources in the Global North is only possible because

a good proportion of the bio-capacity of society in the South is taken up by and to the advantage of these centers [in the triad]. In other words, the current expansion of capitalism is destroying the planet and humanity. The expansions logical conclusion is either the actual genocide of the peoples of the Southas overpopulationor, at the least, their confinement to ever-increasing poverty. An eco-fascist strand of thought is being developed which gives legitimacy to this kind of final solution to the problem.39

A revolutionary process of socialist construction aimed at building a new system of social reproduction in conformity with the demands of necessity and freedom cannot occur without an overall orienting principle and measure of achievement as part of a long-term strategy. It is here, following Mszros, that the notion of substantive equality or a society of equals, also entailing substantive democracy, comes into play in todays struggles.40 Such an approach not only stands opposed to capital at its barbaric heart but also opposes any ultimately futile endeavor to stop halfway in the transition to socialism. Immanuel Kant spelled out the dominant liberal view shortly after the French Revolution when he stated that the general equality of men as subjects in a state coexists quite readily with the greatest inequality in degrees of the possessions men have. Hence, the general equality of men coexists with great inequality of specific rights of which there may be many.41 In this way, equality came to be merely formal, existing merely on paper as Engels pointed out, not only with respect to the labor contract between capitalist and worker but also in relation to the marriage contract between men and women.42 Such a society establishes, as Marx demonstrated, a right of inequality, in its content, like every right.43 The idea of substantive equality, consistent with Marxs notion of communism, challenges all of this. It demands a change in the constitutive cells of society, which can no longer consist of possessive individualists, or individual capitals, reinforced by a hierarchical state, but must be based on the associated producers and a communal state. Genuine planning and genuine democracy can only start through the constitution of power from the bottom of society. It is only in this way that revolutions become irreversible.

It was the explicit recognition of the challenge and burden of twenty-first-century socialism in these terms that represented the extraordinary threat to the prevailing order constituted by the Venezuelan Revolution led by Hugo Chvez. The Bolivarian Republic challenged capitalism from within through the creation of communal power and popular protagonism, generating a notion of revolution as the creation of an organic society, or a new social metabolic order. Chvez, building on the analyses of Marx and Mszros, mediated by Lebowitz, introduced the notion of the elementary triangle of socialism, or (1) social ownership, (2) social production organized by workers, and (3) satisfaction of communal needs.44 Underlying this was a struggle for substantive equality, abolishing the inequalities of the color line and the gender line, the imperial line, and other lines of oppression, as the essential basis for eliminating the society of unequals.

In Communism as an Ideal, Sweezy emphasized the new forms of labor that would necessarily come into being in a society that used abundant human productivity more rationally. Many categories of work, he indicated, would be eliminated altogether (e.g. coalmining and domestic service), and insofar as possible all jobs must become interesting and creative as only a few are today. The reduction of the enormous waste and destruction inherent in capitalist production and consumption would open up space for the employment of disposable time in more creative ways.

In a society of equalsone in which everyone stands in the same relation to the means of production and has the same obligation to work and serve the common welfareall needs that emphasize the superiority of the few and involve the subservience of the many will simply disappear and will be replaced by the needs of liberated human beings living together in mutual respect and cooperation. Society and the human beings who compose it constitute a dialectical whole: neither can change without changing the other. And communism as an ideal comprises a new society and a new [human being].45

More than simply an ideal, such an organizing principle in which substantive equality and substantive democracy are foremost in the conception of socialism/communism is essential not only to create a socialist path to a better future but as a necessary defense of the global population confronted with the question of survival. Dystopian books and novels notwithstanding, it is impossible to imagine the level of environmental catastrophe that will face the worlds peoples, especially those at the bottom of the imperialist hierarchy, if capitalisms creative destruction of the metabolism of humanity and the earth is not stopped midcentury.

According to a 2020 article on The Future of the Human Climate Niche in the Proceedings of the National Academy of Sciences, based on existing trends, 3.5 billion people are projected to be living in unlivable heat outside the human climate niche by 2070, under conditions comparable to those of the Sahara desert.46 Even such projections fail to capture the enormous level of destruction that will fall on the majority of humanity under capitalist business as usual. The only answer is to leave the burning house and to build another now.47

Although untold numbers of people are engaged in innumerable struggles against the capitalist juggernaut in their specific localities all around the world, struggles for substantive equality, including battles over race, gender, and class, depend on the fight against imperialism at the global level. Hence, there is a need for a new global organization of workers based on the model of Marxs First International.48 Such an International for the twenty-first century cannot simply consist of a group of elite intellectuals from the North engaged in World Social Forum-like discussion activities or in the promotion of social-democratic regulatory reforms as in the so-called Socialist and Progressive Internationals. Rather, it needs to be constituted as a workers-based and peoples-based organization, rooted from the beginning in a strong South-South alliance so as to place the struggle against imperialism at the center of the socialist revolt against capitalism, as contemplated by figures such as Chvez and Amin.

In 2011, just prior to his final illness, Chvez was preparing, following his next election, to launch what was to be called the New International (pointedly not a Fifth International) focusing on a South-South alliance and giving a global significance to socialism in the twenty-first century. This would have extended the Bolivarian Alliance for Peoples of Our America to a global level.49 This, however, never saw the light of day due to Chvezs rapid decline and untimely death.

Meanwhile, a separate conception grew out of the efforts of Amin, working with the World Forum for Alternatives. Amin had long contemplated a Fifth International, an idea he was still presenting as late as May 2018. But in July 2018, only a month before his death, this had been transformed into what he called an Internationale of Workers and Peoples, explicitly recognizing that a pure worker-based International that did not take into account the situation of peoples was inadequate in confronting imperialism.50 This, he stated, would be an organization, not just a movement. It would be aimed at the

alliance of all working peoples of the world and not only those qualified as representatives of the proletariatincluding all wage earners of the services, peasants, farmers, and the peoples oppressed by modern capitalism. The construction must also be based on the recognition and respect of diversity, whether of parties, trade unions, or other popular organizations of struggle, guaranteeing their real independence. In the absence of [such revolutionary] progress the world would continue to be ruled by chaos, barbarian practices, and the destruction of the earth.51

The creation of a New International cannot of course occur in a vacuum but needs to be articulated within and as a product of the building of unified mass organizations expanding at the grassroots level in conjunction with revolutionary movements and delinkings from the capitalist system all over the world. It could not occur, in Amins view, without new initiatives from the Global South to create broad alliances, as in the initial organized struggles associated with the Third World movement launched at the Bandung Conference in 1955, and the struggle for a New International Economic Order.52 These three elementsgrassroots movements, delinking, and cross-country/cross-continent alliancesare all crucial in his conception of the anti-imperialist struggle. Today this needs to be united with the global ecological movement.

Such a universal struggle against capitalism and imperialism, Amin insisted, must be characterized by audacity and more audacity, breaking with the coordinates of the system at every point, and finding its ideal path in the principle of from each according to ones ability, to each according to ones need, as the very definition of human community. Today we live in a time of the perfect coincidence of the struggles for freedom and necessity, leading to a renewed struggle for freedom as necessity. The choice before us is unavoidable: ruin or revolution.

Read more:
The Renewal of the Socialist Ideal - Monthly Review

University of Illinois research: Decline in bird numbers related to nicotine-based herbicides – Agri News

URBANA, Ill. Bird biodiversity is rapidly declining in the United States. The overall bird population decreased by 29% since 1970, while grassland birds declined by an alarming 53%.

Valuable for so much more than flight and song, birds hold a key place in ecosystems worldwide. When bird numbers and varieties dwindle, pest populations increase and much-needed pollination decreases. Those examples alone negatively impact food production and human health.

Likely reasons for the far-reaching and devastating declines include intensified agricultural production, use of pesticides, conversion of grassland to agricultural land, and climate change.

A new study from University of Illinois points to increased use of neonicotinoid insecticides as a major factor in the decline, said Madhu Khanna, distinguished professor in agricultural and consumer economics at U of I and co-author on the paper, published in Nature Sustainability.

Khanna said numerous studies have shown neonicotinoids nicotine-based pesticides negatively affect wild bees, honey bees and butterflies, but large-scale studies on the pesticides impact on birds have been limited. She speaks more about the topic in a podcast from the Center for the Economics of Sustainability at Illinois.

This represents the first study at a national scale, over a seven-year time period, using data from hundreds of bird species in four different categories grassland birds, non-grassland birds, insectivores and non-insectivores, she said.

We found robust evidence of the negative impact of neonicotinoids, in particular on grassland birds, and to some extent on insectivore birds after controlling for the effects of changes in land use.

Khanna and co-authors Yijia Li, a graduate student at U of I, and Ruiqing Miao, assistant professor at Auburn University, analyzed bird populations from 2008 to 2014 in relation to changes in pesticide use and agricultural crop acreage.

The authors found that an increase of 100 kilograms in neonicotinoid usage per county a 12% increase on average contributed to a 2.2% decline in populations of grassland birds and 1.6% in insectivorous birds.

By comparison, the use of 100 kilograms of non-neonicotinoid pesticides was associated with a 0.05% decrease in grassland birds and a 0.03% decline in non-grassland birds, insectivorous birds and non-insectivorous birds.

Since impacts accumulate, the authors estimate that, for example, 100 kilograms neonicotinoid use per county in 2008 reduced cumulative grassland-bird populations by 9.7% by 2014.

These findings suggest that neonicotinoid use has a relatively large effect on population declines of important birds and that these impacts grow over time.

According to the study, the adverse impacts on bird populations were concentrated in the Midwest, Southern California and Northern Great Plains.

The researchers say the effect of neonicotinoids could result directly from birds consuming treated crop seeds and indirectly by affecting the insect populations they feed on. Consumption of just a few seeds is enough to cause long-term damage to the birds reproduction and development.

The study included data on bird population and species diversity from the North American breeding bird survey, a comprehensive database with data from about 3,000 bird routes across the United States. The researchers correlated the bird data with pesticide use, as well as satellite data on agricultural crop acreage and urban land use.

They examined whether intensified agricultural production and conversion of grassland to agricultural land also contributed to the bird decline. Results showed a small negative effect on grassland birds related to cropland expansion, but no significant effect on other types of birds.

While the use of other pesticides has been flat or declining, neonicotinoid usage has grown exponentially over the past two decades. Neonicotinoids are considerably more toxic to insects and persist longer in the environment, the researchers note.

This research provides compelling support for the re-evaluation of policies permitting the use of neonicotinoids by the U.S. Environmental Protection Agency by incorporating considerations of the implications of these pesticides for bird habitats, the authors conclude.

Read more:
University of Illinois research: Decline in bird numbers related to nicotine-based herbicides - Agri News

NEET 2020: Important topics, subject-wise revision tips to score better – The Indian Express

By: Education Desk | New Delhi | Updated: September 2, 2020 9:02:16 amNEET 2020 is to be held in September 13 (Representational image)

Written by Devadas Krishnan

NEET 2020: With the National Eligibility Entrance Tests (NEET) just two weeks away, it is time for students to gear up for the last phase of preparation before the D-Day. By now, most have already finished with thorough preparation and these last few days should be about revision, practice, and time management. You can do just that with these few helpful tips and enter the exam hall with confidence:

Do not try new study materials instead, focus on NCERT books for conceptual knowledge and revise the notes you have prepared to date. Distribute equal time for all the three sections of the exam physics, chemistry, and Biology. In each of the subjects, start with topics that carry more weightage.

Here are section-wise revision tips for NEET 2020

Biology: In NEET, biology has more weightage than physics and chemistry as it is an important subject for MBBS and BDS students. Naturally, it is also the tie-breaker when it comes to rank allocation after cut-off is released. If two aspirants are tied on the same score, the one who obtains higher marks in biology gets a higher rank. If both still have the same biology marks, those who score high in chemistry are given preference. The most important topics from which students can expect around 4-5 questions are biological classification, plant kingdom, the animal kingdom, cell, human health and disease, ecosystem, the principle of inheritance and variation, human reproduction. Be very thorough with the diagrams.

Read | Best medical colleges in India

Physics: The questions in this section will be a mix of theory and numerical problems allocate time for both. Start with theory as conceptual clarity is important to interpret and solve the numericals. Focus first on important topics including modern physics and semiconductor devices, magnetism and matter, current electricity, newton laws system of particles, and rotation motion.

Chemistry: Start with revising chemical bonding and molecular structure, S- and P- block elements, equilibrium, chemical kinetics, d and f block elements as these are some of the important chapters. Practice chemical reactions and equations.

Make sure that in these last days you can revise all your notes at least twice. Devote about 10-12 hours each day to studies combined with small breaks for an ideal last month study routine. The complete revision will ensure that you are not stressed out about missing topics or feeling unprepared. Solving mock tests and the last few years question papers will help you identify areas that need more attention along with boosting your confidence about topics you are easily able to tackle. With each test, thoroughly analyse your common and often silly mistakes and constantly work upon them.

JEE Main 2020 LIVE updates

While performing mock examinations, ensure that you are timing yourself according to the timeframe of the actual exam. It is best to create an atmosphere like an examination hall, set a three-hour timer, and perform last years question papers. This helps in determining the number of questions that can easily be solved during the exam will help them devise a strategy for the main examination.

Lastly, relax! Preparation for entrance examinations is indeed stressful that too in these unprecedented times where we have all been restricted to our homes. Ensure that you de-stress every day for an hour through any leisure, entertainment activity of choice. It is important to relax and study as stress hampers productivity and learning. Also, do not get overwhelmed with the preparation of your friends and peers.

The author is CEO, MySchoolPage, a Bengaluru-based ed-tech platform providing personalised online tutoring

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NEET 2020: Important topics, subject-wise revision tips to score better - The Indian Express

A feminist response to the pandemic – Resilience

The COVID-19 pandemic has put a spotlight on the essential roles care work and reproductive labor fulfill in our societies. But will it lead to gender liberation?

The COVID-19 pandemic has exacerbated nearly every kind of social injustice. In the Global North, it has disproportionately killed poor people, Indigenous people and people of color. Working-class women, and especially women of color, are not only more at risk of contracting COVID-19 and dying from it, they are also over-represented in essential care work roles including nursing, elderly care, childcare, food service and domestic labor. Confinement in the home has rendered the double burden of everyday domestic labor into an untenable situation even for white, relatively affluent women.

At the same time, the social crisis of COVID-19 has cast a spotlight on the ways that care workers both paid and unpaid keep us alive. Care work, of course, is overwhelmingly relegated to women, who are perceived as naturally nurturing, loving and gentle. Feminists have always raised issues of life and death. The pandemic has inspired and empowered social movements that place care workers in a position of moral and material leverage to enact change. For the second installment of the ROAR Roundtable series, I posed the following question to a panel of activists and scholars:

In retrospect, we should have asked the question in reverse;What does feminism have to contribute to the fight against COVID-19?Indeed, each respondent has, in her own way, answered that very question. With climate change, mass incarceration, intensified state violence, policing of the movement of people across borders, the twenty-first century is becoming a biopolitical century. Given the rapidly changing attitudes towards care work and reproductive labor as our globalized society combats COVID-19, it may finally be time to recognize gender liberation as a practical and necessary achievement.

Eleanor Finley, Associate Editor

COVID-19 has brutally demonstrated what we [at Barcelona en Com] have been saying in Barcelona for the past five years: that we need to put life at the center of municipal politics. Those who were vulnerable before the pandemic those on low incomes, in precarious jobs, with illness and disabilities, the elderly, or those with weak support networks have now been made even more so.

From a feminist perspective, the coronavirus will have serious consequences not just for women, but for everyone who does not fit the hegemonic model of the rich, white, heterosexual man. The more one deviates from this hegemonic profile, the more they will suffer the health, social and economic impacts of COVID-19. Racial inequalities, poverty, immigration status, culture and sexual-affective diversity are all intersectional factors that accumulate and exacerbate gender inequalities in our neighborhoods.

Care work has always been a feminized task, and therefore socially undervalued and underpaid. In the context of COVID-19, frontline work has become even more dangerous and undesirable, meaning that those who are doing it tend to be the most precarious and vulnerable women often migrant women or single parents. Similarly, female sex workers have seen their incomes dry up overnight.

Another important aspect is the double burden faced at home by women with caring responsibilities whether for children or other dependents. In Spain, we have seen women undertaking care work during the day and teleworking into the early morning, doubling their working hours to get everything done. Those who have male partners have seen them volunteering to go to the supermarket for the first time in a context where this was one of the few reasons to legally leave the house.

All of this is unfolding when reactionary political winds are blowing around the world. Thanks to social discontent and chronic poverty, politicians like Trump, Orbn and Bolsonaro have emerged in a manner that resembles the developments of the interwar period that eventually led to the rise of fascism. Such fascist movements feed off a romanticized vision of a non-existent past, promising a return to a natural order that criminalizes social difference and political dissidence. They promise a return to a time in which women were confined to the domestic sphere.

That is why the transformative power offeminizing politicsis so important. Measures like providing mental health support, investing in childcare and guaranteeing food security implicitly value the care work that sustains life itself. And only care and love, in the broadest and most universal sense of these terms, can trump hate.

Eva Abril, teacher, feminist activist and spokesperson of Barcelona En Com in Catalonia

Initially, while the media was reporting the explosion of domestic violence and a higher than usual number of deaths of women killed by violent partners,Southall Black Sisterswere seeing fewer enquiries for our assistance. It seemed counter-intuitive, but theEuropean Network of Migrant Womenreported the same thing. Their member organizations in Finland and Portugal faced a fall in enquiries. It was a mystery.

We speculated as to whether it was because migrant women had less access to technology, whether their movements were so closely monitored by families and spouses that they were unable to seek support, or whether they expected all services to be closed and were waiting it out. However, the situation did not last long and the enquiries quickly started to come in again.

We embarked on a huge re-organization in order to provide the same level of service virtually. The technology had to be overhauled to allow staff to work from home. Funders were generous enough to respond to the need. We were able to buy phones and phone cards for many of the women so that they could access online counseling and case worker support. Even the support group now meets online twice a week. Workers dropped off food parcels and toiletries for migrant women who have no recourse to public funds.

Finding accommodation for these women was the biggest issue. SBS initiated the COVID-19 crisis project, approaching hotels and hostels to provide free accommodation for three months. At first, they came up with nothing. But then, as a result of their efforts, a much better and cheaper accommodation became available. Yet SBS andSolace Womens Aid, who helped to deliver the project, met with real reluctance from the London mayor to fund the project and set aside enough rooms for migrant women.

They did succeed eventually; the women loved their accommodation. It reinforced their self-esteem. They asked why this could not be a permanent solution.

That is the key question to emerge from this crisis, one which should fire up our future political campaigns: if governments can magically find the funds admittedly in self-interest to treat people with humanity during a crisis, then we should settle for nothing less after COVID-19, all the while keeping an eye on whether this is the revolutionary moment to end a rotten system.

Rahila Gupta is a London-based journalist and author working with Southall Black Sisters (SBS), which provides direct services, information and guidance for women experiencing domestic abuse and violence, focusing on migrant women especially of Asian and African-Caribbean descent.

The COVID-19 pandemic exposed many of the social inequalities that shape the life and death conditions of people around the world. It demonstrated, quite graphically, that even in the context of a virus that spreads regardless of ones identity, human-made systems are at the heart of whose lives matter and whose can be discarded. The pandemic provided the occasion to struggle and organize worldwide.

The same groups that have been organizing mutual aid systems in their communities also tend to be those who demand the most radical changes. Black women and women of color have been at the forefront of organizing to meet their communities needs and demands, despite being among the most vulnerable groups affected by the pandemic. Through horizontal, direct actions that aim to solve problems collectively, these people demonstrate that the protection of life is impossible without social reproduction, care work, mutual aid and, frankly, love.

Feminist and revolutionary womens movements have long pointed out that we cannot appeal to the mercy of the state to find solutions to our problems. They recognize that the states bureaucratic system is simply not designed to keep people alive. Managing life and defending life are not the same.

Organizing during the COVID-19 pandemic has in many ways also helped feminize ideas about heroism. During the pandemic, transnational discussions around labor, value and life have bucked romanticized ideas around work and gender and instead asserted that social relations must change. Reforms are not enough for justice; we must change our way of life.

When the Turkish state decided to exclude thousands of political prisoners from COVID-19 amnesty, the Kurdish womens movement reached out to different womens struggles around the world to start an international campaign for the freedom of political prisoners Solidarity Keeps Us Alive.

But why struggle against prisons at such a time?

Despite its role in perpetuating violence, social conflict and injustice, the state often justifies police brutality, surveillance and carceral politics by presenting itself as the sole authority that can grant safety to communities. Who is going to protect you from murderers, rapists and thieves? they ask. The prison is the ultimate institution to represent the notion that human beings are fundamentally flawed, corrupt and evil. This deterministic view of life rejects the possibility of justice through social change; it only serves the authoritarian state.

At the heart of abolitionist perspectives such as those held by the Kurdish womens movement is the idea that freedom and justice are not simply utopias, but are indeed possible. Violence is not fate, but an outcome of systems that can and must be dismantled. In this light, feminists and womens struggles with abolitionist politics present some of the most revolutionary and hopeful visions and practices.

Abolishing injustice means building free societies, as Black abolitionist feminists point out. This mean abolishing rape, domestic violence, poverty and many other issues and not by locking people up but by creating the material conditions for a more just society. And that happens through what the Kurdish womens movement calls a mentality revolution.

Abolishing the system is a call for the radical reorganization of life with social relations that can serve as the new terms of life. In this sense, radical womens struggles embody in the here-and-now that which is necessary to address the COVID-19 crisis and which is imminently realizable: a life without violence and inequality.

Dilar Dirik, Kurdish feminist and research fellow at Oxford University:

As an international alliance of grassroots womens organizations, theInternational Womens Alliancehas witnessed its members battling with all of the contradictions that COVID-19 has exposed and intensified. State and domestic violence against women have reached pandemic proportions as the pressure on families, employment and livelihood increases and the lockdowns confine women at home with abusive partners.

At the same time, women have been forced to double and triple their workloads of unrecognized reproductive labor taking on the care of family, children and elderly relatives as lockdowns suspend schools and public services.

COVID-19 has also been no impediment to continuing wars of aggression by imperialist powers like the US and its allies, including Israels planned annexation of the West Bank and Jordan Valley and Indias growing occupation of Kashmir. While basic health and education systems are weakened, NATO countries are spending billions preparing for war and new ways of dividing the world. In these places, women are on the frontlines of the resistance.

For women, the militarization in response to the COVID-19 crisis also means they will be at risk of suffering more violence through rape, forced displacement, land-grabbing and openly misogynist policies and attitudes promoted by authoritarians like Trump, Bolsonaro, Duterte and Modi. In Latin America, violence against women, which is linked to drug trafficking andmaquiladoraindustries, has reached femicidal proportions. Campaigns to stop this violence are being coordinated across borders and are gaining visibility.

At the same time, COVID-19 has exposed the key role that working women play in society.

In the Global South, small farmers, particularly women, are the majority of food producers. COVID-19 lockdowns have prevented their productive activities. While announcing food scarcity and hunger for themselves and the planet, the monopolization of agribusiness continues unabated.

In the Global North, COVID-19 has starkly revealed the crucial, frontline role of women migrant workers as care workers and in food and agricultural production and distribution. Their plight and precarity as migrant and refugee workers have also been laid bare and sparked struggles and solidarity from other sectors even under the confinement rules.

In the face of all this, women are finding new ways to move forward in struggle through mutual aid, health care and community-based food preparation and distribution. The IWA soon to celebrate its 10th anniversary is connecting from the grassroots to form strong international alliances, build stronger solidarities, exchange analyses and share campaigns.

Members of IWA are at the forefront of food sovereignty struggles both through advocacy and grassroots organizing. Hand-in-hand with the International Migrants Alliance and others, we are helping coordinate struggles that demand fundamental protections and basic rights for migrant workers worldwide.

The very hardships of the COVID-19 crisis are pushing our Alliance forward. Progressive womens movements continue as a vibrant part of struggles for justice and equality by the peoples of the world.

TheInternational Womens Allianceis aglobal alliance of grassroots womens organizations, institutions, alliances, networks and individuals.

In Colombia, as with many other places in the world, the pandemic and the measures taken by the government have had a serious impact on poor communities and informal workers. While the focus of this roundtable is the impact on women involved in womens liberation struggle, it is necessary to highlight that all poor women are going through similar struggles.

The work that most Colombian women do is neither formally recognized nor economically compensated. The lockdowns have had a severe impact on them, because they lost their sources of income necessary to survive the pandemic. These women often rely on the public healthcare system as few can afford private insurance.

For more than a decade, Colombias public healthcare system has suffered cuts and been weakened in favor of a private system. As such, the public system cannot provide high-quality care and those that use the public system are at higher risk if they do get sick.

War in Colombia has also not ceased because of the lockdowns. In fact, many organized communities have reported that the conflict has gotten worse because the government is taking advantage of the situation to militarize many regions.

There has been a noticeable increase in attacks on theGuardias autonomous, unarmed community-based security organizations and the frequency of assassinations of social leaders is also increasing. There have been several cases of rape of Indigenous girls by soldiers, who know that very little can be done in response right now. Due to the focus on the pandemic, this increase in violence has been met with little public outcry.

In its campaign to militarize these regions, this same military has brought the coronavirus to remote parts of the country that had yet to be affected.

Despite these impacts, womens liberation movements and social movements against capitalism gain strength every day, as the current crisis further evidences the need to change the entire system. The means to do so are complicated.

The womens movement participated in the march for dignity walking from Cauca, Arauca and the North East region towards the capital. In the search for shelter, many women have also been participating in massive actions to take back the land in the peripheries of big cities.

The Peoples Congress brings together peasants, Afro-descendants, Indigenous, urban, workers, women, youth in Columbia. Through training, communication and social mobilization, the Congress aims to consolidate popular power in the territories and create an internationalist alternative against patriarchy, capitalism, colonialism and imperialism. The Peoples Congress in Columbia is represented here by Blandine Rachel

Women across the world, besides dealing with intersectional systems of oppression, often do the invisible labor of caring for the most vulnerable. The pandemic exacerbated the vulnerability of many women involved with care work, while simultaneously activating mutual aid networks focused precisely on these very issues. In our international project to gather stories about COVID-19 mutual aid, Colectiva Sembrar have found hopeful models of revolutionary care from Brazil to Portugal, Taiwan and beyond.

In Hsin-Kang, a rural community in Taiwan, the population is largely aged, and most of its households are poor peasant families. At a communal dining space in Hsin-Kang, where elders come and gather, a woman in her 60s contributes by cooking for the people every day. Despite having severe rheumatoid arthritis and constant physical pain, she still insists on providing for those in her community who are older and more vulnerable.

Similar examples of frontline community work can also be found in Lisbon, Portugal. Women in Lisbon have come together to form Plataforma Geni, an online platform to empower migrant women whose vulnerability has been exacerbated during the pandemic. Shortly after the Portuguese government announced that Lisbon would go under lockdown, these women started an online campaign connecting women who could offer free legal and counseling services with women in need of these services.

The platform also collected money to redistribute among undocumented, unhoused or unemployed women whose labor is often invisible, undervalued and overlooked. Plataforma Genis decolonizing feminist practices show us a more equitable future built upon redistribution of power and in which the structural inequalities of race, gender and nationality that sustain colonialism will not prevail.

So far, the governments of Taiwan and Portugal have contained with COVID-19 relatively successfully. However, other governments, such as Brazils, have utterly failed, making networks of care even more important.

In Brazil, again, these networks are led by women. Suzi Soares, who comes from an artistic collective in the periphery of So Paulo, has mobilized thousands of families. Helena Silvestre, also from So Paulo, used the power of Abya Yala, a feminist school she had previously founded, as a hub to provide material, psychological and legal support for mostly Black and Indigenous women in the peripheries andfavelasof the city.

In all cases, this mutual care work is done mainly by women and often remains hidden in the shadows. Yet, this work represents the possibility of a communal and better future. It must not only be made visible, but also redistributed and decolonized.

Chia-Hsu Jessica Chang, Lais Gomes Duarte and Vanessa Zettler of Colectiva Sembrar are co-authors ofPandemic Solidarity: mutual aid during the COVID-19 crisis(Pluto Press).

Teaser photo credit: By Vivian Morales C. from San Antonio, Chile 08/03/2020 Marcha Da Internacional de la Mujer 8M San Antonio, Chile, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=87872539

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A feminist response to the pandemic - Resilience

Trillion Trees: Reducing Wildfire Risk, Protecting People and Wildlife – USDA.gov

Posted by Aurora Cutler, Office of Sustainability and Climate, USDA Forest Service in Forestry

Aug 28, 2020

An opaque, autumn haze smothers much of the western United States from the millions of acres burning across forests in the Sierra Nevada and Rocky Mountains. Fire size and severity are rising in tandem with record heat, low winter snowpack, decreased summer rains, and abundant forest fuels. Wildfires in the West doubled in total size between 2000-2015 compared to the previous 15 years, burning an average 6.8 million acres annually in the last decade. This trend has wide-ranging consequences on the health and productivity of our national forests, our drinking water supplies, and wildlife habitat.

Thats why the U.S. Chapter of 1t.org (us.1t.org), launched today, and supported by the USDA Forest Service, will enhance the long-term resilience of national forests by planting trees and restoring ecosystems over the next 10 years. Planting trees after catastrophic wildfire is becoming increasingly more important to the sustainability of our forests, especially in areas where wildfire wipes out entire stands and the seed source necessary to forests natural regrowth.

The USDA Forest Service manages national forests using a variety of active management techniques to increase resource resilience while sustaining the many benefits and services wildlife and people need and enjoy. Healthy forests support natural stream systems and watersheds, filtering drinking water for 180 million Americans. Our national forests are an important source of rural prosperity, providing forest industry jobs to more than 2.5 million Americans. Wildlife thrives in our national forests.

In areas where we have lost forests to fire, the trillion trees platform provides an opportunity to accelerate the renewal or reproduction of forest benefits, like carbon sequestration and clean water, over natural rates by tapping the expertise and resources of our many partnership groups and other state and local agencies. Currently, the USDA Forest Service has opportunities to increase reforestation rates on 1.3 million acres of national forests, including 700,000 acres of tree planting and 600,000 acres of activities to ensure successful natural regeneration.

Current active forest management techniques, to regenerate, replace, and grow more resilient forests in the future, reduce the likelihood of severe wildfire. By using novel planting techniques we can create forests with more resilience to future wildfires.

The USDA Forest Service is protecting lives and property in forest adjacent communities, with timber harvests, reducing high fuel risk stands, and hazardous fuel treatments, including mechanical thinning and prescribed burning. Our primary tools to address these risks are reducing the amount of hazardous fuels and limiting the number of healthy trees on specified terrain. Hazardous fuel treatments on national forests protect roughly 60 million to 200 million trees per year from wildfire. This year, the USDA Forest Service plans to treat 3.5 million acres of hazardous fuels.

With the momentum of trillion trees platform, it is evident how active forest management can ensure sustainable and resilient forests will endure for future generations.

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Trillion Trees: Reducing Wildfire Risk, Protecting People and Wildlife - USDA.gov

pTeroWhite: a solution for skin brightening, sun protection and anti-ageing – Cosmetics Business

1-Sep-2020

Ingredients | Skin Care

Application of pTeroWhite cream twice daily for 8 weeks was safe, and improved skin texture tone, and helped in keeping skin moisturized, supple and young

Pterostilbene a natural ingredient, a more stable analogue of resveratrol, has been shown to be helpful in the management of several age-related disorders and aging symptoms by modulating age-related physiological mechanisms viz., antioxidant, anti-inflammatory and anti-glycation pathways (1). Preclinical evaluations have shown that the pterostilbene enriched extract has potential antioxidant ability by the virtue of its radicle scavenging activity. The extract effectively scavenged the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) free radical and the activity was comparable to resveratrol and kojic acid. The extract also inhibited the activity the tyrosinase enzyme in vitro and inhibited melanin production and UV induced damage in vivo in the melanocytes (2).

A clinical study evaluated the anti-aging and skin brightening effect of pTeroWhite cream in healthy volunteers. The study was carried out in 38 healthy volunteers by dermatological assessment, non-invasive instrument assessment, and imaging assessment. The cream effectively improved skin brightness, elasticity, reduced the appearance of fine lines, wrinkles, and improved skin texture as compared to baseline. The study concluded that application of pTeroWhite cream twice daily for 8 weeks was safe, and improved skin texture tone, and helped in keeping skin moisturized, supple and young (3).

The company ensures the sustainable supply of the active ingredient through its award-winning 10-year reforestation program in India to cultivate 166,600 kino samplings on 250 acres of forest land.

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pTeroWhite: a solution for skin brightening, sun protection and anti-ageing - Cosmetics Business

National Nutrition Week 2020: Medicinal Properties Of Food You Cannot Miss – NDTV

2020 National Nutrition Week: Eating healthy, homemade and natural foods is important for your health

National Nutrition Week is observed every year from 1st September to 7th September and can be considered a significant period to raise awareness on the therapeutic effects of foods. Food, in its most natural or raw form, can have considerable medicinal properties helping to keep chronic diseases at a bay. Hippocrates (460-377 BC), the well-recognized father of modern medicine, stated "Let food be thy medicine and medicine be thy food" to predict the relationship between appropriate foods for health and their therapeutic benefits. The truth in this saying is widely recognized even today and is gaining momentum.

The term "nutraceuticals" is an amalgamation of "nutrition" and "pharmaceutical" which precisely signifies a nutrition supplement obtained from natural food to prevent, manage, or treat diseases. Functional foods are health-benefiting foods in their raw or cooked form and not necessarily consumed in the form of diet supplements.

Also read:6 Nutritionist Recommended Homemade Detoxifying Teas You Must Try

Macronutrients like carbohydrates, fats, proteins, and micronutrients like vitamins, and minerals, along with phytochemicals, all contribute significantly to human health and well-being. Mentioned below are significant plant compounds and their subsequent therapeutic benefits on health:

1. Lycopene: Found in tomatoes, pink grapefruit, guava, papaya, and watermelon. Lycopene possesses strong antioxidant activity and may protect against the formation of cancer mainly prostate, bladder, and cervical cancer. Lycopene containing fruits and vegetables exert cancer-protective effect via a decrease in oxidative and other damage to DNA.

2. Phenolic acids: Found in berries, cherries, apples, kiwi, wheat, oats, and legumes. Phenolic acids have strong anti-inflammatory properties and are readily absorbed from the foods. They help prevent cell damage and reduce the oxidation of bad cholesterol (LDL), thereby reducing the risk of heart diseases.

3. Resveratrol: Found in grapes, peanuts, cocoa, blueberries, and raisins. Resveratrol helps manage blood pressure, help reduce high cholesterol levels, and prevent the risk of heart diseases and cancer. It also acts as an anti-inflammatory agent and can inhibit the growth of cancerous cells. The skin of dark grapes contains the highest amount of resveratrol.

Raisins contain resveratrolPhoto Credit: iStock

Also read:Ease PMS Symptoms With This Simple Morning Routine: Try It Today!

4. Saponins: Saponins are reported to possess antitumor and anti-mutagenic activities and can lower the risk of human cancers, by preventing cancer cells from growing. Saponins are phytochemicals that can be found in peas, soybeans, spinach, tomatoes, potatoes, alfalfa, and clover. Saponins can boost the immune system and can also help lower cholesterol levels.

5. Ellagic acid: Found in strawberries, cranberries, walnuts, pecans, pomegranates, and the best source, red raspberry seeds. It is also found in peaches and pomegranates. Ellagic acid and resveratrol are two important components to reduce the risk of cancer and coronary heart diseases. It can prevent various infections and can help your body to detoxify naturally.

6. Anthocyanins: Anthocyanins are the pigments that give cranberries their rich, red color. These are also found in blueberries and blackberries. Anthocyanins function as strong antioxidant compounds, counteract inflammation in the body and lower blood sugar levels in people with diabetes. Anthocyanins can help you manage your weight better because of their strong anti-obesity effects. They also possess antibacterial properties and can keep bacterial infections at a bay.

Also read:What Is Emotional Eating? Our Nutritionist Shares Tips On How You Can Stop Doing This

For a long time, natural products obtained mainly from plants have been used as a prominent source of therapeutic agents for the prevention and treatment of many chronic diseases. Diet alone may not replace medicines in all possible circumstances but it can definitely build the foundation of a strong and healthy body system that requires the least dependency on medicines.

(Nmami Agarwal is nutritionist at Nmami Life)

Disclaimer: The opinions expressed within this article are the personal opinions of the author. NDTV is not responsible for the accuracy, completeness, suitability, or validity of any information on this article. All information is provided on an as-is basis. The information, facts or opinions appearing in the article do not reflect the views of NDTV and NDTV does not assume any responsibility or liability for the same.

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Resveratrol Market In-Depth Analysis on the Future Growth Prospects and Industry Trends Adopted by the Competitors | (2020-2027) – The News Brok

The Global Resveratrol MarketIndustry Report is a professional and in-depth study on the current state of the Resveratrol Market by CMI. The Resveratrol market is supposed to demonstrate a considerable growth during the forecast period of 2020 2027. The company profiles of all the key players and brands that are dominating the market have been given in this report. Their moves like product launches, joint ventures, mergers and acquisitions and the respective effect on the sales, import, export, revenue and CAGR values have been studied completely in the report. The scope of this Resveratrol market report can be expanded from market scenarios to comparative pricing between major players. The emerging trends along with major drivers, challenges and opportunities in the market are also identified and analysed in this report.

Resveratrol help organizations to develop cogent, coherent plans of action to improve their performance.

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Resveratrol Market report provides a thoroughly researched abstract of the key players with considerable shareholdings at a global level regarding demand, sales, and income by providing better products and services. Research Report outlines a forecast for the Resveratrol market between 2020 and 2027. In terms of value, the Resveratrol industry is expected to register a steady CAGR during the forecast period.

The report offers a systematic presentation of the existing trends, growth opportunities, market dynamics that are expected to shape the growth of the Resveratrol market. The various research methods and tools were involved in the market analysis, to uncover crucial information about the market such as current & future trends, opportunities, business strategies and more, which in turn will aid the business decision-makers to make the right decision in future.

The report begins with a brief introduction and market overview of the Resveratrol industry followed by its market scope and size. Next, the report provides an overview of market segmentation such as type, application, and region. The drivers, limitations, and opportunities for the market are also listed along with current trends and policies in the industry.

The key players profiled in this report include:

SkinCeuticals, Evolva SA, DSM Nutritionals, Jeunesse Global, VitaMonk, Helix Healthstore, Terraternal, Andorra Life, ResVitale, LLC, Endurance Products Company, RevGenetics, SiChuan Xieli Pharmaceutical Co., Ltd., and others.

Regions included:

o North America (United States, Canada, and Mexico)

o Europe (Germany, France, UK, Russia, and Italy)

o Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)

o South America (Brazil, Argentina, Colombia)

o Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

Detailed Segmentation:

By Application:CosmeticsDietary SupplementsPharmaceuticalOthersGlobal Resveratrol Market, By Dosage Form:TabletCapsuleLiquid

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Key Benefits:

o This study gives a detailed analysis of drivers and factors limiting the market expansion of Resveratrol

o The micro-level analysis is conducted based on its product types, end-user applications, and geographies

o Porters five forces model gives an in-depth analysis of buyers and suppliers, threats of new entrants & substitutes and competition amongst the key market players

o By understanding the value chain analysis, the stakeholders can get a clear and detailed picture of this Resveratrol market

The research study can answer the following Key questions:

Table of Contents

Report Overview: It includes the Resveratrol market study scope, players covered, key market segments, market analysis by application, market analysis by type, and other chapters that give an overview of the research study.

Executive Summary: This section of the report gives information about Resveratrol market trends and shares, market size analysis by region and analysis of global market size. Under market size analysis by region, analysis of market share and growth rate by region is provided.

Profiles of International Players: Here, key players of the Resveratrol market are studied on the basis of gross margin, price, revenue, corporate sales, and production. This section gives a business overview of the players and shares their important company details.

Regional Study: All of the regions and countries analyzed in the Resveratrol market report is studied on the basis of market size by application, the market size by product, key players, and market forecast.

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Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Southeast Asia.

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Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having office at global financial capital in the U.S. Our client base includes players from across all business verticals in over 150 countries worldwide. We are uniquely positioned to help businesses around the globe deliver practical and lasting results through various recommendations about operational improvements, technologies, emerging market trends and new working methods.

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Resveratrol Market In-Depth Analysis on the Future Growth Prospects and Industry Trends Adopted by the Competitors | (2020-2027) - The News Brok

Phil Baran on the Quest to Make Chemistry Boring Again – Bio-IT World

September 3, 2020| Phil Baran of Scripps Researchdelivered the keynote address at the Drug Discovery Chemistry Virtual meeting last Thursday, providing a captivating mixture of hardcore synthetic chemistry and his underlying philosophy. The focus of his talk was translational chemistry, the synthetic techniques that move beyond esoteric academic pursuits to find mainstream use in creating successful pharmaceuticals.

Baran began by reviewing the most commonly used reactions in modern drug synthesis, finding that most are boring, not specific to any synthetic stage, and fall primarily into the four categories of amide bond formation, reductive amination, Suzuki coupling, and Buchwald-Hartwig Ullman Goldberg reactions. Baran says this is not because medicinal chemists lack creativity but is instead an indicator that a truly useful synthetic reaction implies a wide scope, is simple to run, and is an essential transformation of readily available starting materials, paraphrasing Barry Sharpless. Thus, If you can invent a reaction that becomes boring, thats a great compliment, according to Baran. Some of the reactions we thought of as being exciting 20 years ago, we take for granted today.

Barans group is focused on the synthesis of marine natural products, such aspalauamine, which often requires the development of new synthetic techniques. Baran quickly recounted how aMinisci-type radical-based reaction using silver to accomplish direct arylation of electron-deficient heterocycles started a new direction for the lab that culminated in the development of zinc sulfinate salts (now known asdiversinates, available from Sigma-Aldrich) that easily form radicals in the presence of Tert-butyl hydroperoxideand add to electron-deficient heterocycles. The facile nature of the reaction was demonstrated unconventionally by thedifluoromethylationof caffeine in oolong tea performed in a paper cup. Baran believes industry players saw this and said to themselves if this is working in this rather cowboy way on late-stage tea-derived material, its probably going to work at the end of my analog campaign to explore late-stage diversification.

Baran repeated at several points throughout his talk thathe wants his efforts to simplify synthesis.We dont want to do chemistry that is gimmicky; we want to enable a transformation that couldnt be easily or safely done before.He showed the example ofapharma-useful,5-step, weeklong synthetic effort toadd atrifluoromethylcyclopropanegroup to a heterocyclewith3% yield.Working in one-electron chemistry usinga sulfinate salt, the same product could be obtained in 2 steps, effectively removing theconcept ofstages from this synthesis.

He spoke about radical chemistry with heterocycles and reported collaborative work with Donna Blackmonds group to show that, contrary to some popular opinion that radical reactions are poorly controlled, substituted heterocycles have predictable and pH-modulable reactivity, work that was published inJACS(https://dx.doi.org/10.1021%2Fja406223k). He showed an example from a Gilead patent where a trifluoromethylation site could be easily predicted usingChemdraw13C NMR shift predictionsthe smallest shift indicating the most nucleophilic site is where substitution will occur.

Reviewing the scope of these reactions seven years after their development illuminated their ubiquity in pharmaceutical patents (https://doi.org/10.1021/acs.jmedchem.8b01303). According to Baran, What was remarkable to us, was that although the chemistry was developed from the vantage point of late-stage functionalization people were using this at any stage. He showed additional examples of similar chemistry to add olefins and to form carbon-nitrogen bonds, again greatly reducing steps and improving yields in select examples.

Baran discussed his labs development in collaboration with Pfizer to develop strain-release amination reagents, spring-loaded, highly strained bridged building blocks that can be used to quickly appendbioisosteressuch aspropellanes, azetidines, andcyclobutanes. Again, he discussed how this chemistry, using what were once considered molecular oddities and developed to work in late-stage modification, is amenable to all synthetic stages and can even be used in the extreme for bio-modification, such as selectively reacting with cysteine in a larger peptide molecule. This work found publication inScience(https://doi.org/10.1126/science.aad6252). He highlighted that the bicyclobutanes accessible with strain-release reagents arebioisosteresfor acrylamide and have very similar GSH reactivity. According to Baran, The strain-release reagents are fast ways of decorating your compounds kind of like you put ornaments on your Christmas tree.

The strain-release reagents were extended to the use of housanes, strained bridged five-membered rings that can be openedstereospecificallyby amines, alcohols, thiols, acids, selenides, amides, and even carbon nucleophiles to obtain useful products. This work appeared inJACS(https://doi.org/10.1021/jacs.6b13229). Onceagainhe shared a great example of a simple-lookingaminoflurocompound that previously required an 8-step synthesis but could be prepared rapidly in 2 steps using ahousane.

He highlighted other recent work involving the activation of carboxylic acids to redox-active esters for synthesizing ketones, alcohols, and amines through one-electron chemistry, work that was reported inJACS(https://doi.org/10.1021/jacs.9b02238).

Baran spent a few minutes discussing the hot new (but incredibly old) field of electrochemistry. Barans group worked closely with IKA to help develop theElectraSyn, a small benchtop device with apotentiostatfor accurately applying current to enable redox chemistry that he says basically every pharma company now has on hand. You cant get cheaper than an electron, but according to Baran, cost is not a sufficiently powerful motivator. You need to tell a medicinal chemist about enablement. An example of the utility of this setup was shown with the synthesis of a hindered ether, which Baran said could only previously be achieved after completing a miserable campaign of SN1 addition reactions over 6 days to obtain ~6% yield. Barans group expanded on an interrupted Kolbe-type reaction in which electrochemical oxidation frees carbocations from carboxylic acids to accomplish a direct decarboxylative etherification, and his group optimized reaction conditions to greatly improve yield and tolerate a vast range of substituents. The hindered ether shown prior could now be obtained in just 2 steps, in 15 hours, and with 51% yield. An additional example molecules synthesis was cut from 14 steps over 9 days with 5% yield to 3 steps, 21 hours, and 22% yield. That work was published recently inNature(https://doi.org/10.1038/s41586-019-1539-y).

Baran showedanexpansion of this techniqueto create C-N bonds,trimming thesynthesis of acereblonbinder compound from 6 stepsin6% yield to one step and 52% yield.Again, the method tolerates all sorts of different functionalgroups, and this work is not yet published.

Finally, he shared new unpublished work in which olefins can add to ketones using electrochemical nucleophilic addition and showed a 7-step synthesis of a steroidal hedgehog signaling inhibitor being shortened to a 2-step procedure (though theBocdeprotection step is being optimized). The mechanism is still being elucidated, but they believe a ketal-type radical is forming on the carbonyl, which adds to the olefin.

Baran summarized the synthetic technique developments of his lab and supplemented more philosophy. It started off fundamental, we start with natural products, and it ended up being something that translates to useful chemistry that medicinal chemists use to make useful molecules. Radicals can be really, really useful vehicles to get you into late-stage or early-stage functionalization, he adds.

Will these reactions become boring one day? I hope! he exclaims. Maybe, fiftyyears from now, well look back in curiosity at chemists of our age who had stages in their s
yntheses instead of making everything in 1-3 steps.

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Phil Baran on the Quest to Make Chemistry Boring Again - Bio-IT World

Emmitt Smith on Dak Prescott contract: Cowboys will ruin team chemistry if they ‘try to mess with him’ – CBS Sports

Try as they might, the Dallas Cowboys again failed to get a deal done with Dak Prescott in 2020. It's the second attempt in as many offseasons that's failed to bear fruit, this time the two sides coming as close as they've ever been before the bell finally tolled during last-second talks on July 15. And with that, Prescott will play the 2020 season under a franchise tag that will pay him $31.4 million, and a third attempt to secure a long-term deal will get underway in 2021 -- or the Cowboys will likely find themselves paying $37.7 million on a second tag. Time will tell how it all shakes out, but Emmitt Smith is unequivocal in his stance on the matter.

Smith told the Cowboys earlier this offseason they "can't play chicken" with Prescott, and has yet another warning for them as they ready for their Sept. 13 opener against the Los Angeles Rams. Never one to bite his tongue, Smith says the fate of the entire locker room is at stake when it comes to contract negotiations with Prescott.

"If you try to mess with Dak Prescott, trying to mess with him mentally, try to mess with him from a financial standpoint -- you're going to effect the whole chemistry of that entire team," Smith said on a recent episode of Tiki and Tierney, CBS Sports Radio/CBS Sports Network. "That's one of the things I've seen many coaches, organizations, and owners do too often and just destroy the chemistry of a ball-club. I've seen it happen and I don't think they need to do that with Dak."

Smith once drew the ire of some fans who felt he undervalued Prescott during the Ezekiel Elliott holdout in 2019, attributing much of the Cowboys offensive success to the prowess of the run game. He's since made it clear several times over his belief in Prescott is unwavering, in that he views the two-time Pro Bowler as the franchise quarterback of both now and the foreseeable future.

"I do think Dak is the guy going forward," said Smith. "There's no question in my mind about that. Dak Prescott is in control of that offensive unit, is in command of that offense, and he has earned the respect as the leader of that team. The way he plays the game translates in that."

Prescott, who believes he will "be a Cowboy for the rest of his career,"is once in again in prime position to increase his value on the open market -- something the Cowboys are desperately trying to keep him from reaching. He logged a career-best season in 2019 under first-year offensive coordinator Kellen Moore, and the addition of Mike McCarthy as head coach, another receiving weapon in rookie first-round pick CeeDee Lamb and the promotion of playmaking tight end Blake Jarwin to starter sets him up for even more dominance in 2020.

If all goes to plan, and the team's receivers don't again lead the league in drops, Prescott could set a franchise record in single season passing yards -- after just narrowly missing doing so last season -- en route to setting a much bigger franchise record: namely, highest-paid player in Cowboys history.

That is, of course, if they take Smith's advice.

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Greensburg Salem seeks right chemistry in pursuit of 700th win | Trib HSSN – TribLIVE

By: Bill Beckner Jr.Wednesday, September 2, 2020 | 10:54 PM

Shane Dunlap | Tribune-Review

Greensburg Salem quarterback Hayden Teska practices with teammates on Monday, July 27, 2020 at Offut Field in Greensburg.

Shane Dunlap | Tribune-Review

Greensburg Salems Alex Briggs works on conditioning on Monday, July 27, 2020 during varsity football practice at Offut Field in Greensburg.

Shane Dunlap | Tribune-Review

Greensburg Salems Billy McChesney works on conditioning on Monday, July 27, 2020 during varsity football practice at Offut Field in Greensburg.

Shane Dunlap | Tribune-Review

Greensburg Salems Jayden Stevens works on individual drills with teammates on Monday, July 27, 2020 at Offut Field in Greensburg.

Shane Dunlap | Tribune-Review

Greensburg Salem football players work on conditioning during team practice on Monday, July 27, 2020 at Offut Field in Greensburg.

Dont get too used to the starting lineup Greensburg Salem football coach Dave Keefer rolls out in the opening game.

Or, the following week. Or, maybe even the one after that.

We are going to try a lot of things and move guys around until we find something that works, Keefer said. Our lineup in (the first game) will be different from the one in Week 3. It might take until Week 3 to find a spot for everybody.

The Golden Lions, who are chasing history they sit one win away from No. 700 have a young and mostly inexperienced group, but one that shows flashes of talent nonetheless.

An abundance of seniors graduated, so Keefer and his staff are looking to fill key voids with players who look the part but are unproven.

We have a lot of young guys, Keefer said. Well see how everyone develops and grasps what we want to do. Last year we steered the truck. This year were building it.

As for the milestone victory, it would suit the team best to get it sooner rather than later so it can focus on a new spot in the Class 4A Greater Allegheny Conference. Imagine the delight that would have come with an opening-night win over Hempfield, but that cant happen because the first three weeks of the schedule were wiped out because of a delayed start to the season.

Well take it any way we can get it, Keefer said. It would be nice to get it early. Its one of those things, the elephant in the room.

Leading rusher Alex Briggs returns for his senior season and will have an experienced line blocking for him. He ran for 621 yards last fall on 108 carries.

Four linemen who started in last years quarterfinal playoff game against Blackhawk are back, including senior right guard Joe McGough, junior left guard Billy McChesney, senior right guard Joe Gongaware and senior right tackle Dakota Powell.

Powell will be a fourth-year starter, while McChesney and Gongaware will start for a third straight season.

A fifth would-be starter up front, senior Matt Metrosky, transferred to Greensburg Central Catholic.

With team leader Trent Patrick gone at quarterback, the Golden Lions will turn to junior Hayden Teska, who missed much of last season with a broken collarbone he sustained in Week Zero while playing defensive back.

Hayden is different than Trent in his style, Keefer said. He doesnt have Trents arm, but his accuracy is exceptional and his ability to read the field is really good. He is a really heady player. He is composed and confident in himself.

Keefer said sophomore Christian McChesney, junior Clayton Hudspath and sophomore Kaleb Riggs were competing to start at center.

Sophomore Rashad Canady and junior J.C. Wallish also should see carries in the backfield.

We have three good guys with good talent and ability, Keefer said. But Briggs will carry the majority of the mail.

About six or seven guys were looking to make an impact at receiver.

Linebacker looks like the strength of the defense, led by Briggs. Others are juniors Jayden Stevens and Preston Henry and Wallish.

Canady also could fit into that rotation if he doesnt line up in the secondary, and Teska is another top defensive back.

Keefer enjoyed competing in the Big Eight Conference, which included 4A heavyweights Thomas Jefferson and Belle Vernon, last years WPIAL finalists.

The Greater Allegheny will house Armstrong, Hampton, Highlands, Indiana, Knoch, Mars and Plum.

I wish we would have stayed where we were, to be honest, Keefer said. You know where you sit with those teams. We played four of the final four teams last year. From a coachs perspective there was a preparation aspect that went into it.

Dont get me wrong, I like the new conference. We play five 5A teams, basically, so it doesnt get any easier.

Schedule

Coach: Dave Keefer

2019 record: 5-6, 5-2 in Class 4A Big Eight Conference

All-time record: 699-389-39

Date, Opponent, Time

9.11, Plum*, 7

9.18, Knoch*, 7

9.25, at Indiana*, 7

10.2, Hampton*, 7

10.9, Armstrong*, 7

10.16, at Mars*, 7

10.23, at Highlands*, 7

*Class 4A Greater Allegheny Conference game

Statistical leaders

Passing: Trent Patrick*

62-154, 805 yards, 11 TDs

Receiving: Ryan Thomas*

12-171 yards, 2 TDs

Rushing: Alex Briggs

108-621 yards, 3 TDs

*Graduated

Fast facts

The Golden Lions next win will be the 700th in program history. Only Jeannette (756), New Castle (746), Aliquippa (734) and Washington (710) have more than 700 wins in the WPIAL.

Greensburg Salem averaged 18.6 points last season but scored 28 against Mars, a new conference opponent.

Briggs averaged 5 yards a carry as a junior.

Teska also plays baseball and was a starter as a freshman two years ago at catcher.

Bill Beckner Jr. is a Tribune-Review Staff Writer. You can contact Bill by email at bbeckner@triblive.com or via Twitter .

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Influencing the future of science | Sponsored – Chemistry World

Right now is the most exciting time to be part of the materials science industry, says Waters director of material sciences, Damian Morrison.The 21st century is not only an era of fully functioning 3-D printed human organs, its a time in which novel materials are revolutionising mobility with lightweight electric vehicles. It is also an age of collaboration, in which Waters provides a key supporting role in the R&D of higher performing, more sustainable and easier to manufacture polymers across industries. From consumer products to life-saving medical devices plus a myriad between when we talk about polymers, the potential is exponential.

Waters offers its clients the perfect forum in which to further advance the analytical expertise it has been cultivating since the introduction of its GPC 100 the first commercially available gel permeation chromatography (GPC) system in 1963.

Our goal is to get closer to the science and collaborators and 'help deliver innovation that has impact and directly relates to something that is happening in that industry today, Morrison enthuses.

Thats been the primary driver for forming the materials science business, he explains. It will enable us to better serve the dynamic and fast-changing material science industry, and better support Waters customers today, and in the future.

Understanding chemical structures and how they translate into physical properties is fundamental to polymer R&D. In fact, that enigmatic structure versus property relationship drives innovation in labs worldwide. As partners with their own ranges of Water and TA Instruments branded technologies, scientists at Rowan University and Virginia Tech in the US can glean precise and accurate information about those key elements and their relationship.

Specifically, it helpedTim Long and Chris Williams from Virginia Tech define the parameters for a polymer used in the design and manufacturing of a product component with a degradation temperature above 600C.

Through our collaborations, were not just supporting our industrial customers, we are also influencing the future of the science itself

Damian Morrison

And, it is by understanding structureproperty relationships that chemical engineersat Rowan University can effectively assess the biodegradability of polymeric compounds made from biomass feedstock like lignin from trees and the pulp industry. It is how compound chemists deliver against their polymeric objectives day after day.

The chemicalengineering labs at Rowan University are already a US focal point for lignin and biomass R&D, with students exploring routes to sustainable polymers using a suite of Waters and TA Instruments apparatus. But associate professor Joseph Stanziones research intothe potential for herbs and spices to improve energy devices is taking analytical chemistry to a new level.

We see that companies are increasing their commitment to R&D into sustainable polymer innovation

Damian Morrison

Its an altitude that Morrison is happy to help Stanzione andRowan University scale to. A high towards which Morrison sees material innovation businesses headed too. 'We are seeing that companies are in fact increasing their commitment to R&D into sustainable polymer innovation through the allocation of dedicated scientific resources whose sole mission is to develop more eco-conscious polymers and processes.

Morrison is keen to see sustainability as the launch pad for Waters continued growth in expertise. From the principles that underpin Waters' green ambassador Chris Stumpfs analytical chemistry to sharing molecular insight that scientists can draw on.

Our commitment to collaborate with our partners across select applications will remain a key objective for the foreseeable future, says Morrison. 'The nature of our collaborations best highlights our commitment to the materials industry, I feel. Through our collaborations, were not just supporting our industrial customers, we are also influencing the future of the science itself,he adds.

Chemists and polymer scientists across applications are benefitting from the combined analytical chemical structure characterisation capabilities of Waters using chromatography, chemistries and informatics with the property testing expertise of TA Instruments which includes thermal analysis and rheology. Combining these technologies across the extended materials workflow delivers better performing solutions into the materials space.

The synergies created by bringing together Waters' chromatography and mass spectrometry expertise with the robust performance of TA Instruments thermal analysis solutions becomes a huge asset to their partners. Chemists quest to fully understand the structureproperty relationship between chemicals and polymers is better served with the holistic approach that this consolidated offer makes possible.

Watersfelt more like a partnership than a vendor-customer transaction []that was intentional and part of the Waters culture

Damian Morrison

This video series of Waters scientific experts and its accompanying content not only outline how the Acquity Advanced Polymer Chromatography (APC) system enhances polymer analysis, they also emphasises the instrument makers collaborative approach. 'Its true that our insight has been both broadened and refined by our partnerships, and thats a relationship Ive seen from both sides,' says Morrison.

'When I was a compound chemist for Merck Sharp & Dohme back in the 1990s, Waters felt more like a partnership than a vendor-customer transaction. I know now that I was not just lucky in my engagement, and that the approach was intentional and part of the Waters culture.

That ethos is illustrated in Waters' partnership with Rowan University and Virginia Tech in the US as much as it is with its collaborations with Europe-headquartered analytical instrument maker Malvern Panalytical. The pair evaluated the degradation of drug delivery polymers, an analysis only made possible due to the unique combination of high resolution separation using the Waters' APC system with a true multi-detection system from Malvern, the Omnisec Reveal.

The collaboration demonstrated how the combined analytical capabilities of Waters and Malvern can provide R&D scientists higher sensitivity resolution data than ever before meaning better insight into their samples and better products for consumers.

Waters' series of short educational videosdemonstrate the APC system's ability to improve analytical insight into polymer samples faster and more efficiently than ever before.

In partnership with Waters Corporation, weve put together a bundle of free resources to support the precision polymer analysis collection.

Download resources

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Influencing the future of science | Sponsored - Chemistry World

From handprint to fingerprint: Polymer peak analysis | Sponsored – Chemistry World

An evaluation scientist at Waters for over seven years, Willis Martin describes Waters' Acquity advanced Polymer chromatography (APC) system as an 'all-in-one chromatographic analysis tool'.

Waters APC technology supportshigh speed gel permeation chromatography (GPC), normal and even reverse phase separations,gel permeation elution chromatography (GPEC) and hydrophilic interaction liquid chromatography (HILIC). In fact, says Martin,any type of chromatography needed.

In his assessment of products and software packages in Waters range, Martin draws on his experience analysing polymers as Dow analytical chemist. Having used the Acquity APC - specifically for GPC large molecules analysis -- during his lab career at the chemicals giant, his investigations are taken very much from a chemist's perspective.

'With the molecules that chemists work on getting smaller and smaller, it was time for the analytical chemistry solution providers to help scientist characterise at these diminishing molecular scales,' he says.

In terms of a timely analytical chemistry innovation, the more resolved and better defined peaks the APC delivers will ensure polymer scientists maintain pace with an ever-evolving materials science sector.'We need to know exactly what this polymer is because the slightest modification could mean completely different results in the end. What the APC provides is just that much more level of detail,' says Martin.

Using APC with polymer quaternary solvent manager (p-QSM) technology offers the ultimate flexibility to analyse the most complex polymer blends and additives, says Martin. It allows the APC to perform gradient separations that were otherwise impossible with the previous iteration of the APC. In fact, analysis of complex blends and additives is possible using standard polymer chromatography, gradient polymer elution chromatograph (GPEC), and reverse-phase liquid chromatography with a single system.

With its high tolerance of harsh organic solvent use, the APC helps polymer researcher achieve their high throughput goals using GPC technique use. With faster analysis, polymer scientists get proof of concept faster, which translates to faster time to market and greater market share.

In partnership with Waters Corporation, we've put together a bundle of free resources to support the precision polymer analysis collection.

Download resources

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From handprint to fingerprint: Polymer peak analysis | Sponsored - Chemistry World

Troopers: Truck driver charged in Monday Thruway chemical spill at Rotterdam – The Daily Gazette

ROTTERDAM -- The tractor-trailer driver state police say caused a massive spill of iron oxide down a stretch of the Thruway early Monday has been charged..

Mohamed M. Sheriff, 29, of Philadelphia, was charged with one count of misdemeanor reckless endangerment, as well as multiple traffic infractions that include leaving the scene of a property damage accident, state police said.

Troopers say Sheriff's tractor trailer struck the Gordon Road overpass just after midnight Monday, ripping open his trailer and spilling a bag containing iron oxide onto the Thruway.

Sheriff was aware of the damage and spill, but continued on to his destination at Benjamin Moore in Amsterdam, state police said.

Troopers found Sheriff there later Monday morning as he unloadedhis cargo, state police said.

State police tracked down the truck by following markings from the spilled iron oxide to the Thruway exit at Amsterdam. They found the truck and Sheriff at about 5 a.m. The truck was identified as from the N&V Group of Philadelphia.

The chemical spill affected about a half-mile of the highway. Crews spent most of the morning cleaning it up.

Iron oxide is deemed hazardous due to the possibility of it being inhaled. If inhaled at high rates, it can cause irritation to the respiratory tract and eyes. It can be safely removed from a vehicle by washing it.

The westbound lanes betweenExits 25 and 26 were closed for the entire morning. It had reopened just after noon. A final closed lane reopened later in the day.

Most of the material was swept up by contractors in protective clothing. Crews used water to rinse the remainder off the road. The DEC monitored the cleanup.

All westbound traffic was diverted off the Thruway at Exit 25 torenter at Exit 26, state police said.

Sheriff was processed and released to appear in court later this month.

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Troopers: Truck driver charged in Monday Thruway chemical spill at Rotterdam - The Daily Gazette

ExclusiveKendall Jenner and Devin Booker’s Chemistry Is ‘Off the Charts’ – inTouch Weekly

Heating up!Kendall Jennerand NBA starDevin Bookers chemistry is off the charts, a source exclusively tellsIn Touchof their blossoming romance.

They cant keep their hands off each other, the insider reveals, adding, They have a natural rapport that isnt forced.

The hunky athlete checks all of the boxes for the runway model, the source notes. Devin makes her laugh [and] makes her feel safe. Additionally, the new couple share a lot of the same interests. They love traveling together, they love eating really bad food, they like the same movies, there are no awkward moments.

Kendall and Devin first sparked dating rumors in April after being spotted on a road trip together to Sedona, Arizona. Just one month later, the brunette beauty was seen giving the athlete a lift from Van Nuys Airport in Los Angeles.

Since then, they have done little to stop the speculation and were seen flirting on social media on August 11. Only four days after, Kendall and Devin were photographed out to dinner with sisterKylie Jenneron August 15. In photos obtained by TMZ, the trio can be seen getting into a black SUV following their meal.

Shortly after their dinner date, the dynamic duo was pictured getting handsy during a beach trip in Malibu on August 22. While trying to hide from photographers behind a white fence, Devin was spotted kissing the supermodels chest as she wore a barely-there bikini.

On Sunday, August 30,Us Weeklyconfirmed the pair are officially dating, but they are taking things slow. Kendall and Devin are seeing each other but arent serious and are just having fun with each other, a source told the outlet. Its easy because they get along well and he also gets along great with her family.

When it comes to her relationships, theKeeping Up With the Kardashiansstar does her best to keep her romances under wraps. I got a glimpse of how my sisters dealt with [the attention] and its cool to learn from that, she toldVogue Australiain May 2019.

For me, a lot of things are very special and very sacred, like my friends and relationships, and I personally think that bringing things into the public makes everything so much messier.

When it comes to love, it looks like Kendall knows exactly what she wants!

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ExclusiveKendall Jenner and Devin Booker's Chemistry Is 'Off the Charts' - inTouch Weekly

The GLOBAL CHEMICAL, BIOLOGICAL, RADIOLOGICAL, AND NUCLEAR DEFENSE MARKET is expected to grow by $ 5.36 bn during 2020-2024 progressing at a CAGR of…

New York, Sept. 03, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "GLOBAL CHEMICAL, BIOLOGICAL, RADIOLOGICAL, AND NUCLEAR DEFENSE MARKET 2020-2024" - https://www.reportlinker.com/p05955038/?utm_source=GNW Our reports on CBRND market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors. The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by the growing chemical and biological warfare by militants and development of nuclear weapons. In addition, growing chemical and biological warfare by militants is anticipated to boost the growth of the market as well. The CBRND market analysis includes product segment and geographic landscapes.

The CBRND market is segmented as below: By Product CBRN protection CBRN detection CBRN decontamination CBRN simulation and training

By Geographic Landscape North America Europe APAC MEA South America

This study identifies the increased use of improvised explosive devices as one of the prime reasons driving the CBRND market growth during the next few years. " The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters. Our CBRND market covers the following areas: CBRND market sizing CBRND market forecast CBRND market industry analysis"

Read the full report: https://www.reportlinker.com/p05955038/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The GLOBAL CHEMICAL, BIOLOGICAL, RADIOLOGICAL, AND NUCLEAR DEFENSE MARKET is expected to grow by $ 5.36 bn during 2020-2024 progressing at a CAGR of...

Daniel Wang, Institute Professor and pioneer in biochemical engineering, dies at 84 – MIT News

Daniel I.C. Wang, an MIT Institute Professor who was considered one of the founding fathers of the field of biochemical engineering, died Saturday in Cambridge, Massachusetts. He was 84.

During his long career at MIT, Wang contributed to many aspects of biochemical engineering a field that involves genetically engineering microbes and human cells to produce useful proteins. His research spanned all phases of the process, including fermentation, monitoring and control of bioprocesses, enzyme technology, product purification, and protein folding.

In 1985, Wang was the driving force behind the launch of MITs Biotechnology Process Engineering Center (BPEC), which was founded as a multidisciplinary research center bringing together faculty from the departments of Biology, Chemistry, and Chemical Engineering.

Dannys work and impact in the field of biochemical engineering were profound, and led to a major shift in the growth of chemical engineering at the interface with biology, says Paula T. Hammond, the David H. Koch Professor and head of the MIT Department of Chemical Engineering. He extended chemical engineering concepts to bioreactors and the first efforts in bioprocesses, enzyme technology, and mammalian cell cultures, among many other accomplishments. Chemical engineering has lost a giant, and the department has lost a good friend and incredible mentor to our faculty, researchers, and numerous alumni.

The establishment of MITs BPEC coincided with the overall emergence of biotechnology as an industry and a research field. Wang and other early pioneers developed ways to use emerging knowledge about the genetics of microbes to engineer them to produce useful products. Among many other projects, Wang worked on engineering E. coli to increase their production of desired recombinant proteins. He also studied techniques for increasing yields of therapeutic recombinant proteins and monoclonal antibodies from mammalian cells.

He also worked closely with the biotechnology industry and was one of the original members of Biogens scientific board, where he was instrumental in the companys development of the manufacturing of complex biopharmaceuticals.

Born in Nanking, China, Wang worked to establish international ties between MIT and universities in other countries, particularly in Asia. He established a joint program in molecular engineering of biological and chemical systems with the National University of Singapore, which became part of the Singapore-MIT Alliance for Research and Technology (SMART).

Wang, who served as the Chevron Professor of Chemical Engineering before being named an Institute Professor, was also known for his dedication to his students. Noubar Afeyan, a former student of Wangs who is now the CEO of Flagship Pioneering and a member of the MIT Corporation, described him as a friend and cherished mentor.

Danny touched thousands all over the world by inspiring generations of students, industrial collaborators, and fellow professors. He was confident yet humble, tough yet caring, serious yet playful, with an insatiable appetite for good Chinese food. We will miss Danny and work hard to make his legacy proud, Afeyan says.

In recognition of Wangs pioneering research, MITs Frontiers of Biotechnology Lectureship was renamed for him in 2014. Now known as the Daniel I.C. Wang Lecture, the lectureship honors achievements at the frontiers of biotechnology, and the distinguished scientists and engineers responsible for them.

Dan Wangs influence as a teacher, mentor, researcher, and friend has been monumental to so many people who have become the leaders in building a biotech industry and biochemical engineering as a profession, says Charles Cooney, the Robert T. Haslam Professor of Chemical Engineering at MIT. Though saddened by his passing, we celebrate his legacy of unwavering nurturing of students and colleagues to address challenging problems with innovative solutions.

Wang earned two degrees from MIT a BS in 1959 and an MS in 1961. In 1963, he earned a PhD in chemical engineering from the University of Pennsylvania. He joined the MIT faculty in 1965 and was named an Institute Professor, MITs highest faculty honor, in 1995. He received numerous honors and awards, including the Amgen Biochemical Engineering Award in 1995 and the William H. Walker Award from the American Institute of Chemical Engineers in 1994. He was also a member both of the National Academy of Engineering and the American Academy of Arts and Sciences.

In 2019, the American Institute of Chemical Engineers established an award in his honor the D.I.C. Wang Award for Excellence in Biochemical Engineering. The award is given annually and recognizes individuals for their contributions to the field and to the practice of biochemical engineering through their position in industry or academia as exemplified by Professor Wang in his 50 years of contributions, according to the AIChE.

Wang also contributed to national efforts in biotechnology, as chair of the Membership Committee of the National Academy of Engineering, a member of the National Biotechnology Policy Board at the National Institute of Health, a member of the National Research Council Committee on Bioprocess Engineering, a member of the National Research Council Committee on Biotechnology, and a member of the Board of Biology of the National Research Council.

He also co-authored five books, published more than 250 papers, and was awarded 15 patents.

Wang is survived by his wife, Victoria; his son, Keith; his daughter-in-law Katherine; his two granddaughters, Veronica and Emily; his sister, Judy, and her family; and his sister-in-law, Cecile. Plans for a memorial will be announced at a later date.

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Daniel Wang, Institute Professor and pioneer in biochemical engineering, dies at 84 - MIT News