Dolphin reproductive research aided by UH drones – UH System Current News

A resident dolphin mother and her new calf at the Hilton Waikoloa Village are helping scientists to evaluate the increasing pressures on wild dolphin populations such as Hawaiis spinner dolphins. The University of Hawaii at Mnoas Marine Mammal Research Program (MMRP) and Dolphin Quest are collaborating on a scientific drone study aimed at better understanding the health of dolphin populations.

Scientists are concerned that frequent human activities in the spinner dolphins environment are disrupting the dolphins natural behaviors, which may be adversely affecting their reproduction.

Fabien Vivier, a PhD student with MMRP, has been operating a drone over a pregnant bottlenose dolphin at the Dolphin Quest facility at the Hilton Waikoloa Village on Hawaii Island. He collected baseline data in order to do the same on the open ocean to detect pregnancy in female dolphins. This will help to estimate pregnancy rates for the populations of dolphins in the wild.

Studying dolphins at Dolphin Quest is really helpful, because it allows us to verify our methodologies at a specific known stage of pregnancy, which couldnt be accomplished working only in the wild, Vivier said. This information is quite relevant to studying and conserving other species such as Hawaiis spinner dolphins because, even though the species are different, they share many similarities. If we are able to detect pregnancy from a drone perspective in the bottlenose dolphin, the likelihood of detecting pregnancy in a spinner dolphin is very good.

Scientists said continuing reproduction supports critical wildlife conservation and is also good for the dolphin social group.

Reproduction and calf-rearing is important for dolphin welfare. It is a natural and enriching social behavior for dolphins in the wild and in modern zoos, aquariums and marine life parks, said Dolphin Quest Marine Mammal Reproduction Specialist Holley Muraco. Accredited facilities like Dolphin Quest have excellent reproductive success, which leads to long-term population sustainability and eliminates the need for collection from the wild.

Vivier said the next step of surveying spinner dolphins in the wild is scheduled for October. He plans to tweet about the experience through the MMRPs Twitter account.

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‘You feel the risk of your decision no matter what’: How parents feel about the return to school – CNBC

Pupils wearing facemasks arrive to attend classes at Moor End Academy in Huddersfield, northern England on September 11, 2020.

OLI SCARFF | AFP | Getty Images

LONDON After months out of school, children around the world are returning to the classroom. And while parents feel it's best for their kids, shaking those first-day nerves has been a challenge.

Homeschooling has been the norm for many families over the last five months, as a lot of schools only stayed open to the children of key workers, due to the coronavirus pandemic.

Gillian Harvey, a writer who lives in a small town near Limoges in France, said that she was initially nervous about her five children returning to school.

"I made sure I told them all the facts properly before they went back, but also that they are human and there may well be a time when they forget a hygiene measure (e.g. forget to wash their hands properly) and that it's OK and human and they must just do their best and follow the rules to the best of their ability," Harvey told CNBC via email.

She's started to feel better about the situation since their return.

"I think the schools are handling it well," she said, with the use of social bubbles for younger children, along with social distancing and hand gel for older students.

Children in France returned to schools at the beginning of September. But by the end of the first week, French Education Minister Jean-Michel Blanquer said 22 schools had closed across the country and in its territories due to virus cases. On Mondayafter the sixteenth straight day of rising hospitalizations school trips and student parties were suspended in Marseille.

To date, France has reported 425,870 cases of Covid-19 and 30,958 related deaths, according to data compiled by Johns Hopkins University.

"I always thought there would be a couple of cases at first people are returning from holidays and I wish there'd been some sort of encouragement for families to stay at home the week before term started," Harvey said.

But she added that it was "a horrible time for parents you feel the risk of your decision no matter what it is."

Another mother in London, who preferred to remain anonymous, told CNBC over the phone that she felt her son's school had gone beyond the average measures to ensure a safe return to the classroom.

She welcomed her son's return to school, not only as a parent balancing childcare with working from home these past months, but also for his mental health.

U.K. Prime Minister Boris Johnson has emphasized this repeatedly in recent weeks, saying it is "vitally important" for children to return to school in September, with British parents possibly facing fines if they refuse to comply.

The mother CNBC spoke to, however, did indicate that she was concerned about rising infections among the wider public and how transmission could then filter through schools, referring to the reported coronavirus outbreaks in 339 schools in England and Wales last week. In the U.K., 373,559 people have contracted Covid-19 and 41,726 have died from the virus.

She felt that the U.K.'s contact tracing system was "not sufficient."

"I advocate for a strong local contract tracing and informing system, like what (South) Korea has put in the place," she said.

Knowing about an outbreak in a local school, restaurant or supermarket would keep people better informed and help manage community transmission more efficiently, she argued.

Transitional kindergartner Caleb Simon, 4, waits with fellow students outside Weaver Elementary School on the first day of in-person learning in Rossmoor, CA, on Tuesday, September 8, 2020.

Jeff Gritchen | Getty Images

Indeed, experts have highlighted some points that might be reassuring to parents.

Mike Tildesley, an associate professor who specializes in infectious disease control at the University of Warwick in the U.K., told CNBC that the highest risk of transmission was actually "probably within households" with "unregulated mixing" between groups.

He said this was the reason behind a lot of the localized restrictions that have been imposed in the north of England in recent weeks, clamping down on meetings between different households, due to rising cases. The U.K. government announced measures last week that meant from Monday, people were unable to meet socially in groups from other households of more than six people.

Tildesley said that one of the difficulties is that schools are one of the last public areas to re-open.

He said it was "unfortunate timing" with the "R" number the virus' reproduction rate hovering around one, which is when it is considered dangerous. He referred back to research Warwick University published in June that suggested the re-opening of schools alone was unlikely to lead to a second wave of coronavirus cases.

"My real worry is that schools could end up getting the blame for cases starting to rise, because all this other stuff has happened, but actually there's an awful lot that's happened to get to this point," Tildesley added.

Olivia Swann, a clinical lecturer in pediatric infectious disease at the University of Edinburgh, told CNBC via email that she had worked on a study of 138 hospitals across England, Scotland and Wales, looking at children admitted with the coronavirus.

Admissions for children under 19 years' old accounted for less than 1% of those across all age groups. And, of those 651 children that were admitted, six died from the virus all of which had "complex health issues." What's more, more than 40% of children in that study had one or more underlying health conditions, some which were very complex. But Swann added that most did not need intensive care input and made good recoveries.

"As a parent, a children's doctor, and a scientist, I find our study very reassuring at a time when children are returning to school," Swann said. However, she stressed that she was not suggesting people become complacent, but carry on with practices such as physical-distancing and hand washing.

Data published Tuesday by the Department for Education estimated that 12% of state school pupils in England did not attend class in the first week of September. During the last academic year, the overall absence rate was 4.7%.

Examining this estimate together with data from the most recent school census, which reported a state-school pupil population of just over 8 million, indicated that as many as 974,400 pupils were not present at school during the first week of term.

Similar statistics released at the beginning of September by the Scottish Government showed that over 15.5% of pupils missed school on the first Friday backover 100,000 pupilsthough only 22,821 of those absences were designated "Covid-19 related." The data from England's Department for Education includes pupils absent for both Covid-19 and non-Covid-19 related reasons.

Attendance figures for Welsh and Northern Irish schools are yet to be made available by their respective governments.

CNBC's Jordan Butt contributed to this report.

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'You feel the risk of your decision no matter what': How parents feel about the return to school - CNBC

Psychometric evaluation of the Swedish version of the 30-item endometriosis health profile (EHP-30) – BMC Blogs Network

Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D'Hooghe T, De Bie B, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29:40012.

CAS Article Google Scholar

Vetvicka V, Lagan AS, Salmeri FM, Triolo O, Palmara VI, Vitale SG, et al. Regulation of apoptotic pathways during endometriosis: from the molecular basis to the future perspectives. Arch Gynecol Obstet. 2016;294:897904.

CAS Article Google Scholar

Lagan AS, Vitale SG, Salmeri FM, Triolo O, Frange HB, Vrtanik-Bokal E. Unus pro omnibus, omnes pro uno: a novel, evidence-based, unifying theory for the pathogenesis of endometriosis. Med Hypotheses. 2017;103:1020.

Article Google Scholar

Vitale SG, Capriglione S, Peterlunger I, La Rosa VL, Vitagliano A, Noventa M. The role of oxidative stress and membrane transport systems during endometriosis: a fresh look at a busy corner. Oxidative Med Cell Longev. 2018;7924021.

Schomacker ML, Hansen KE, Ramlau-Hansen CH, Forman A. Is endometriosis associated with irritable bowel syndrome? A cross-sectional study. Eur J Obstet Gynecol Reprod Biol. 2018;231:659.

Article Google Scholar

Culley L, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, et al. The social and psychological impact of endometriosis on womens lives: a critical narrative review. Hum Reprod Update. 2013;19:62539.

Article Google Scholar

Young K, Fisher J, Kirkman M. Womens experiences of endometriosis: a systematic review and synthesis of qualitative research. J Fam Plan Reprod Heal Care. 2015;41:22534.

Article Google Scholar

Vitale SG, La Rosa VL, Rapisarda AMC, Lagan AS. Endometriosis and infertility: the impact on quality of life and mental health. J Endometr Pelvic Pain Disord. 2017;9(2):1125.

Article Google Scholar

La Rosa VL, De Franciscis P, Barra F, Schiattarella A, Tropea A, Tesarik J. Sexuality in women with endometriosis: a critical narrative review. Minerva Med. 2020;111(1):7989.

PubMed Google Scholar

Jia S-Z, Leng J-H, Shi J-H, Sun P-R, Lang J-H. Health-related quality of life in women with endometriosis: a systematic review. J Ovarian Res. 2012;5:29.

Article Google Scholar

Bourdel N, Chauvet P, Billone V, Douridas G, Fauconnier A, et al. Systematic review of quality of life measures in patients with endometriosis. PLoS One. 2019;14:e0208464.

CAS Article Google Scholar

La Rosa VL, De Franciscis P, Barra F, Schiattarella A, Trk P, Shah M. Quality of life in women with endometriosis: a narrative overview. Minerva Med 2020;111(1):6878.

Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118:6229.

CAS Article Google Scholar

Nnoaham K, Hummelshoj L, Webster P. Europe PMC funders group impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96:36673.

Article Google Scholar

Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27:12929.

Article Google Scholar

De Graaff AA, DHooghe T, Dunselman GA, Dirksen C, Hummelshoj L, Simoens S, et al. The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey. Hum Reprod. 2013;28:267785.

Article Google Scholar

Grundstrm H, Gerdle B, Alehagen S, Berter C, Arendt-Nielsen L, Kjlhede P. Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis. Acta Obstet Gynecol Scand. 2019;98:32736.

Article Google Scholar

Abbott JA. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up. Hum Reprod. 2003;18:19227.

CAS Article Google Scholar

Marques A, Bahamondes L, Aldrighi JM, Fernandes LF, Augusto K, Brilhante A, et al. Quality of life in Brazilian women with endometriosis assessed through a medical outcome questionnaire. J Reprod Med. 2004;49:11520.

PubMed Google Scholar

Neelakantan D, Omojole F, Clark TJ, Gupta J, Kahn K. Quality of life instruments in studies of chronic pelvic pain: a systematic review. J Obstet Gynaecol. 2004;24:8518.

CAS Article Google Scholar

Jones G, Kennedy S, Barnard A, Wong J, Jenkinson C. Development of an endometriosis quality-of-life instrument: the endometriosis health Profile-30. Obstet Gynecol. 2001;98:25864.

CAS PubMed Google Scholar

van de Burgt TJM, Hendriks JCM, Kluivers KB. Quality of life in endometriosis: evaluation of the Dutch-version endometriosis health profile30 (EHP-30). Fertil Steril. 2011;95:18635.

Article Google Scholar

Vincent K, Kennedy S, Stratton P. Pain scoring in endometriosis: entry criteria and outcome measures for clinical trials. Report from the art and science of endometriosis meeting. Fertil Steril. 2010;93:627.

Article Google Scholar

National Board of Health and Welfare (Socialstyrelsen). National Guidelines For Endometriosis Care (in Swedish). 2018. https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/nationella-riktlinjer/2018-12-27.pdf Accessed 28 Feb 2020.

Grundstrm H, Rauden A, Olovsson M. Cross-cultural adaptation of the Swedish version of endometriosis health Profile-30. J Obstet Gynecol. 2020. https://doi.org/10.1080/01443615.2019.1676215.

Terwee CB, Bot SDM, de Boer MR, van der Windt D, Knol D, Dekker J, et al. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60:3442.

Article Google Scholar

Cronbach LJ, Warrington WG. Time-limit tests: estimating their reliability and degree of speeding. Psychometrika. 1951;16:16788.

CAS Article Google Scholar

Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15:15563.

Article Google Scholar

Wickstrom K, Spira J, Edelstam G. Responsiveness of the endometriosis health Profile-30 questionnaire in a Swedish sample: an observational study. Clin Exp Obstet Gynecol. 2017;44:4138.

CAS PubMed Google Scholar

Jones G, Jenkinson C, Taylor N, Mills A, Kennedy S. Measuring quality of life in women with endometriosis: tests of data quality, score reliability, response rate and scaling assumptions of the endometriosis health profile questionnaire. Hum Reprod. 2006;21:268693.

Article Google Scholar

Statistics Sweden (Statistiska Centralbyrn) Higher education in Sweden (In Swedish) 2019. https://www.scb.se/hitta-statistik/sverige-i-siffror/utbildning-jobb-och-pengar/utbildningsnivan-i-sverige/ Accessed 4 Dec 2019.

Chauvet P, Auclair C, Mourgues C, Canis M, Gerbaud L, Bourdel N. Psychometric properties of the French version of the endometriosis health Profile-30, a health-related quality of life instrument. J Gynecol Obstet Hum Reprod. 2017;46:23542.

CAS Article Google Scholar

Jenkinson C, Kennedy S, Jones G. Evaluation of the American version of the 30-item endometriosis health profile (EHP-30). Qual Life Res. 2008;17:114752.

Article Google Scholar

Verket NJ, Andersen MH, Sandvik L, Tanbo TG, Qvigstad E. Lack of cross-cultural validity of the endometriosis health Profile-30. J Endometr Pelvic Pain Disord. 2018;10:10715.

Article Google Scholar

Jia S-Z, Leng J-H, Sun P-R, Lang J-H. Translation and psychometric evaluation of the simplified Chinese-version endometriosis health Profile-30. Hum Reprod. 2013;28:6917.

Article Google Scholar

Khong S-U, Lam A, Luscombe G. Is the 30-item endometriosis health profile (EHP-30) suitable as a self-report health status instrument for clinical trials? Fertil Steril. 2010;94:192832.

Article Google Scholar

Nogueira-Silva C, Costa P, Martins C, Barata S, Alho C, Calhaz-Jorge C. Validation of the Portuguese Version of EHP-30 (The Endometriosis Health Profile-30). Acta Med Port. 2015;28:34756.

Article Google Scholar

Nojomi M, Bijari B, Akhbari R, Kashanian M. The assessment of reliability and validity of Persian version of the endometriosis health profile (EHP-30). Iran J Med Sci. 2011;36:849.

PubMed PubMed Central Google Scholar

van de Burgt TJM, Kluivers KB, Hendriks JCM. Responsiveness of the Dutch endometriosis health Profile-30 (EHP-30) questionnaire. Eur J Obstet Gynecol Reprod Biol. 2013;168:924.

Article Google Scholar

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The effect of control measures on COVID-19 transmission in Italy: Comparison with Guangdong province in China – Infectious Diseases of Poverty -…

Collection of cases data

We obtained data of confirmed COVID-19 cases that were reported in Guangdong province, Italy and other places in the world from the Health Commission of Guangdong Province, the Ministry of Health of Italy, and the World Health Organization [2831]. The data include infected cases in the world and Europe since January 26 to March 12, 2020, the cumulative confirmed cases, newly reported cases, death cases, and recovered cases in Italy from January 30 to March 13, 2020 and in Guangdong from January 19 to February 26, 2020. The number of cumulative confirmed cases in Italy was 2 between January 30 and February 5, 2020, and was 3 from February 5 to February 19, 2020. The numbers of cumulative death and recovered cases were 0 from January 30 to February 19, 2020. We exclude the data in these periods and will focus on the Italian data between February 20 and March 13 because this is the early stage of the Italian outbreak, which allows us to compare the effectiveness of the prevention and control measures used in Italy and Guangdong by analysis of those datasets.

In Fig.1, we select February 20 as the first day when there were 4 cumulative confirmed cases in Italy, and January 19 as the first day when Guangdong had one cumulative confirmed case. On February 28 Italy closed schools in Lombardy, the most serious epidemic area, when the number of cumulative confirmed cases was already 650 (Fig.1a). This number is similar to the confirmed cases (i.e. 683) in Guangdong on February 2. In comparison, the Guangdong government took Seven Measures policy (e.g. blockade of unnecessary public places) on the third day (January 21) to prevent the spread of the epidemic and shut down all schools on January 28, when there were only 241 cumulative confirmed cases (Fig.1b). Therefore, Italy closed schools about 5 days (January 28 February 2) later than Guangdong. In Fig.1c we see that the number of cumulative cases has already exceeded 10 thousand in Italy, however, the newly confirmed cases in Guangdong began to decline since the 37th day and reached the peak of cumulative cases at only 1347 (Fig.1d). In summary, it took 14 days for Guangdongs reported cases to decline since its cumulative confirmed cases exceeded 1000.

In the early stage of the epidemic in Italy, the government did not take many prevention measures across the country. Thus, to study the epidemic of this stage, we extend the classical deterministic susceptible-exposed-infectious-removed (SEIR) epidemic model by dividing the population into susceptible (S), exposed (E), symptomatic/asymptomatic infected (I/A), confirmed (H) and recovered (R) compartments. The susceptible and exposed populations are further partitioned into quarantined susceptible (Sq) and quarantined suspected individuals (Eq). Based on the previous research [22], we adopt an autonomous model to study the early stage of the outbreak. We assume that the individuals exposed to the virus are quarantined with a proportion q by contact tracing. If the quarantined individuals are successfully infected, they will move to Eq compartment, otherwise they move to the Sq compartment. The individuals who exposed to the virus but were missed in the contact tracing with rate 1q can either move to the compartment E or still stay in compartment S, depending on whether they are infected or not. We assume that the successful transmission probability is and the contact rate is c. The infected individuals can be detected and then isolated at a rate of I or move to the compartment R at the rate of I due to recovery. The death rate of the infectious individuals with symptoms I and the isolated infected individuals H is . We also assume that the asymptomatic infectious is neither dead nor hospitalized. With these assumptions the model can be described by

$$ begin{array}{l} frac{dS}{dt}=-left(beta c+cq(1-beta)right)Sfrac{(I+theta A)}{N}+lambda S_{q},\ frac{dE}{dt}=beta c (1-q)Sfrac{(I+theta A)}{N}-sigma E,\ frac{dI}{dt}=sigma rho E-left(delta_{I}+alpha+gamma_{I}right)I,\ frac{dA}{dt}=sigma(1-rho)E-gamma_{A}A,\ frac{{dS}_{q}}{dt}=(1-beta)cqSfrac{(I+theta A)}{N}-lambda S_{q},\ frac{{dE}_{q}}{dt}=beta cqSfrac{(I+theta A)}{N}-delta_{q}E_{q},\ frac{dH}{dt}=delta_{I}I +delta_{q}E_{q}-left(alpha+gamma_{H}right)H,\ frac{dR}{dt}=gamma_{I}I+gamma_{A}A+gamma_{H}H.\ end{array} $$

(1)

The more detailed definitions of variables and parameters for model (1) are provided in Table1. As the population size is much larger than the size of the outbreak, i.e. S(t)/N1, the basic reproductive number R0 of model (1) is given by the following formula by utilizing the next generation matrix [32].

$$R_{0}=frac{betarho c(1-q)}{delta_{I}+alpha+gamma_{I}}+frac{beta(1-rho) ctheta(1-q)}{gamma_{A}}. $$

The above model will be used to study the early stage of the outbreak. However, with a series of prevention and control measures being implemented by the government, the autonomous model needs to be modified. Because of the difference before and after the implementation of control measures, piecewise functions of the contact rate and diagnosis rate are introduced to the autonomous model.

The contact rate is a constant in the autonomous model, i.e. the average number of susceptible individuals that an exposed people can contact without any control measures in a unit time. As the action of regional or national lockdown came into effect, peoples contact will gradually decrease. Thus, we assume that the contact rate is an exponential decreasing function of time t after the government has taken the control measures. The contact rate c(t) is assumed to take the following form:

$$ c(t)=left{begin{array}{l} c_{0}, tleq t^{*}+tau,\ left(c_{0}-c_{b}right)e^{-r_{1}(t-t^{*}-tau)}+c_{b}, t>t^{*}+tau.\ end{array}right. $$

(2)

Here c0 denotes the contact rate at the initial time without control measures, cb denotes the minimum contact rate under the current control strategies (cb

Similarly, because the efficiency of detection and availability of medical resources vary, we assume that the diagnosis rate is a time-dependent piecewise function rather than a constant. It is an increasing function when medical resources are adequate and a decrease function when they are not. The duration of diagnosis 1/I(t) is given by the following form:

$$ frac{1}{delta_{I}(t)}=left{begin{array}{l} frac{1}{delta_{I0}}, tleq t^{*},\ left(frac{1}{delta_{I0}}-frac{1}{delta_{If}}right)e^{-r_{2}(t-t^{*})}+frac{1}{delta_{If}}, t>t^{*},\ end{array}right. $$

(3)

where I0 is the diagnosis rate at the initial time. If the efficiency of detection is increasing with time t, then the diagnosis rate I(t) will increase. The parameter r2 measures how fast the diagnosis rate increases (i.e. the duration of diagnosis decreases) as more medical equipments or resources become available. The final diagnosis rate If is usually larger than I0. However, if the medical resource is inadequate, the diagnosis rate I(t) can decrease and the final diagnosis rate If can be less than I0.

According to the basic reproductive number R0, time-varying contact rate Eq. (2) and diagnosis rate Eq. (3), the effective reproductive number Rc(t) of time-dependent model is given by the following formula:

$$R_{c}(t)=frac{betarho c(t)(1-q)}{delta_{I}(t)+alpha+gamma_{I}}+frac{beta(1-rho) ctheta(1-q)}{gamma_{A}}. $$

Although the governments mandatory intervention plays a major role in epidemic control, peoples behavior changes such as keeping social distancing, wearing facial masks and washing hands due to media and expert suggestions cannot be ignored. Hence, the piecewise function similar to the previous contact rate and diagnosis rate is applied to the transmission rate . Considering that the impact of behavior change on the spread of the disease is not as great as the government mandatory intervention, the exponential change form is not used. If the number of reported confirmed cases increases, the public will enhance self-protection measures. Thus, we assume that the transmission rate is inversely proportional to reported confirmed cases H(t). The time-dependent transmission rate (t) takes the following form:

$$ beta(t)=left{begin{array}{l} beta_{0}, if frac{1}{klog(H(t))}>1,\ beta_{0}frac{1}{klog(H(t))} \ end{array}right. $$

(4)

where k represents the indicator measures strength of peoples awareness of self-prevention. The larger the value of k, the smaller the transmission rate.

According to the total population of Italy and the epidemic situation on February 20, 2020, we set initial values to be S(0)=60 480 000, H(0)=3 and R(0)=0. According to the WHO [33], the incubation period of COVID-19 is about 7 days. Thus, =1/7. The quarantined individuals were quarantined for 14 days, thus =1/14. We obtain other unknown parameter values by fitting data on reported number of cumulative confirmed cases, death cases and recovery cases from February 20 to March 10 in Italy. We utilized the nonlinear least-square (NLES) method in Matlab to fit model solution to the real data sets, as shown in Fig.2. The estimated parameter values are listed in Table1.

Fitting of the autonomous model to the data of COVID-19 in Italy from February 20 to March 10. (a) shows the number of cumulative confirmed cases, (b) shows the number of death cases, and (c) shows the number of recovered cases

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Scientists find possible signs of life in the clouds of Venus – The Economist

Sep 14th 2020

OF EARTHS TWO planetary neighbours, Mars and Venus, it is Venus which shines brighter in the sky, comes closer in space, and is more similar in size and physical structurealmost Earths twin. But over the past 60 years it has been to Mars that science has paid the most attention. There are currently six operational spacecraft in orbit around it and two more on its surface; more are on their way. Venus is observed by a single small satellite. Yet following a new discovery made with telescopes on Earth, it is Venus which arguably now looks more likely to harbour the thing that planetary science cares most about: life.

The telescopesthe James Clerk Maxwell Telescope (JCMT) in Hawaii and ALMA in Chilework not in visible light, but with sub-millimetre- and millimetre-wave radiation, which lies in between infrared light and radio waves. The hot depths of Venuss atmosphere give off a fair bit of radiation at these wavelengths. The molecules in the cooler air above them absorb some of it as it passes out into space; the specific wavelengths absorbed depend on the molecules doing the absorbing. As a team of scientists from various institutions has now reported in Nature Astronomy, one of the chemicals thus revealed appears to be PH3, or phosphine, a molecule composed of phosphorous and hydrogen.

This is a striking anomaly. In an atmosphere composed mostly of carbon dioxide, like Venuss, phosphine should be able to survive only briefly before chemistry destroys it. So for it to be present persistentlythe observers reckon it makes up perhaps 20 parts per billion of the atmospheresomething must be producing it at the same rate as atmospheric chemistry gets rid of it. But what?

On Earth, where there are on average a few parts per trillion of phosphine in the atmosphere, its presence seems to be almost entirely because of chemists (among other things, it is a potentially deadly by-product of badly run meth labs) and microbes. That means it has strong potential as what astrobiologists, who look for life and the things that make it possible in extraterrestrial contexts, call a biomarker.

This would be tantalising enough in itself. What makes it yet more fascinating is that for decades a small band of scientists has been suggesting that Venus might be able to support microbial life. The discovery in the 1960s that the surface of Venus was far hotter than the ovens used to sterilise surgical instruments seemed to rule out any chance of life there; the challenge which the extreme conditions pose both to life and to human technology did a lot to swing attention out towards Mars. But a few scientists wondered if there might be life above the searing surface. The water droplets in Earths clouds contain living bacteria; though Venuss clouds are incredibly acidic, might they too be inhabited by some sort of super-hardy bug? The detection of phosphine is thus a potential sign of life in a place people have previously imagined as habitable.

From the farthest planets to the nearestThe idea of detecting life through an otherwise inexplicable anomaly in a planets spectrum dates back to the 1960s, when it was given voice by James Lovelock, a British chemist and inventor. It came into its own when astronomers started discovering planets around other stars, or exoplanets. Most of these planets are in inhospitably unearthlike orbits, but some sit within what astronomers call the habitable zonethe zone in which, under various conditions, the surface might support liquid water. Astrobiologists like Sara Seager of MIT started putting real effort into working out what anomalous gases might be visible once they got telescopes good enough to analyse the spectra of such planets atmospheres.

A few years ago some of the scientists who work with Dr Seager and in her team started to get interested in phosphine. Though it is not clear how microbes make it, or something which decomposes into it, its association with life is pretty clear (among other things, penguin guano seems rich in the stuff). There seem to be no appreciable mechanisms for making it abiotically either in the depths of the Earth or through the photochemical reactions driven by sunlight which create other short-lived gases in the atmosphere. And it has some nice distinct spectral lines which should be eventually observable in the infrared light from some sorts of exoplanet.

In 2017 Jane Greaves of the University of Cardiff, thinking along similar lines, decided to see if the JCMT could be used to detect longer-wavelength phosphine lines (which are less affected by Earths atmosphere) in the atmosphere of Venusnot an exoplanet, but much easier to study. She and her colleagues saw something in the appropriate part of the spectrum; but the signal was weak. Dr Greaves decided to pursue the idea further using ALMA, an array of 66 antennae in the Atacama Desert which is much more powerful than the JCMT. Those observations, made last year, provided a significantly better signal-to-noise ratio.

After the first observations, Dr Greaves team and Dr Seagers heard about each other and pooled their resources. Dr Seagers team has worked out that any microbial metabolism producing phosphine would probably work best in a very acidic environmentrather like that of Venus, where much of the cloud deck is almost pure sulphuric acid. In the early 2000s some scientists suggested that curious features in the way that the clouds absorb ultraviolet light might be down to microbes making some sort of pigment or other compound to protect themselves from itperhaps pure sulphur, which could be made through photosynthesis. Dr Seager, Dr Greaves and some of their colleagues developed a new model for how such life might function, with cells reproducing in the cloud droplets and turning into desiccated spores as the droplets fall towards the surface; rising winds then bring some of these spores back up to the clouds, where they get absorbed intoor possibly catalyse the creation ofnew droplets in which to reproduce once again. This hypothesis is being published in the journal Astrobiology.

This speculation is fascinating, but also of a sort which might raise alarm bells. The team did not look at the whole spectrum dispassionately to see what was there; it specifically sought out a feature that could be explained by phosphine, a molecule in which at least some of the scientists were already invested, and found what they were looking for. What is more, as they say in their paper, we emphasise that the detection of PH3 is not robust evidence for life, only for anomalous and unexplained chemistry. Two things need to happen before things get truly exciting. Other teams need to make their own observations, ideally at other wavelengths. And a really thorough search for ways of making phosphine without biology under the conditions seen on and above Venus needs to draw a blank.

Mars retreatsOn the first of these two requirements, the history of methane on Mars provides a cautionary tale. In 2004 scientists using three Earth-based telescopes and a spacecraft orbiting Mars all thought they had detected what appeared to be the spectral signature of methane in the planets atmosphere. It was a classic Lovelock anomaly. Chemical models insist that methane does not last all that long in the Martian atmosphere, so these observations suggested there had to be a continuous source of the gas. And on Earth most, though not all, methane is produced by microbes. What was more, there was an increasingly widespread belief that, although there is now only a smidgen of water on the surface of Mars, there might be plenty more below it, perhaps in deep aquifers. On the Earth microbesincluding microbes that produce methaneare found many kilometres below the surface. Maybe Mars had a similar deep biosphere?

Maybe. But if so, there is currently no persuasive evidence that it is producing methane. In 2018 the European Space Agencys ExoMars Orbiter started to look at trace gases in Marss atmosphere with much more sensitive instruments than had been used before. It has seen no evidence of methane at anything like the level previously claimed, which makes it hard to credit the earlier observations. It is true that NASAs Curiosity rover has detected methane more recently; but with ExoMars coming up empty, those detections are hard to take at face value.

This tale of woe makes it very clear that looking through the Earths thick atmosphere for signs of a tiny amount of gas in the atmosphere of another planet is an exacting and error-prone undertaking. Hence the need for observations of phosphine over Venus from other groups using other instruments. At the same time, though, the chain of reasoning which made a deep Martian biosphere plausible applies to theories about life above Venus, too.

Mars appears always to have been a pretty cold, dry place. But in the distant past, when it had a thicker atmosphere, it clearly had running and standing water at its surface, at least sporadically; Curiosity is currently studying mudstones laid down in an ancient lake. As Mars lost its atmosphere its surface became ever more arid and frigid. That put evolutionary pressure on any microbes previously living in those surface waters to migrate deeper and deeper into the still warm and moist subsurface.

The surface of Venus, too, has dried out over its history: but through heating, not cooling. For billions of years the Sun has been growing brighter, thus changing the boundaries of its habitable zone. In the case of Mars, this warming was not enough to offset the cooling effect of losing most of the atmosphere. On Venus, though, it prompted what atmospheric scientists call a runaway greenhouse effect, boiling away the seas which many scientists believe to have graced the planets youth. If there had been microbes in the surface waters of Venus before this catastrophe, evolution would have urged them not into the depths, as it did on Mars, but into the skies, where even today the temperature remains bearable and water remains liquid, though admittedly in droplets not oceans.

This idea has been much further from the mainstream than that of subsurface life on Mars. One reason may be that, though the existence of Earths deep biosphere is quite widely appreciated, beyond some recherch microbiological circles the fact that there are also bacteria busily metabolising up in the sky is widely ignored. And to be fair, the high-biosphere analogy is not perfect. Though bacteria live in Earths cloud droplets there is as yet no evidence that they reproduce there. That may be because actually proving that it is happening is technically very difficult, but it may also be because the aerial microbes have no particular need to do so; the Earths surface, and the creatures that roam across it, provide bacteria with all the locales for reproduction they could possibly require.

The idea of Venuss atmosphere as a refuge is a beguiling story of life finding a way. But it remains very speculative. If the phosphine is indeed present as described, there needs to be a strenuous effort to find, or rule out, non-biological sources. The team behind the detection has done some of this; it argues convincingly that the phosphine cannot come up from volcanoes, drift down from comets, or be made in mid-air through photochemistry. But the chemistry that happens on surfaces can be very different to what happens in mid air, and Venuss atmosphere, as well as offering extremes of temperature, pressure and acidity, has surfaces to spare, both in its cloud decks and in the hazes that float above and below them. Imaginative chemists should have a field day working through ever more abstruse possibilitiesand may make some very interesting discoveries of their own on the way.

Then there is the possibility of going to take a closer look. NASA has not launched a mission to Venus since the 1980s, though some of its spacecraft have swung past it on their way elsewhere. But two Venus missions have reached the final stage of the selection process for the next round of its Discovery program of small planetary missions. One, VERITAS, is an orbiter mainly intended to map the surface in more detail; the other, DAVINCI+, features a small chemistry lab that would descend through the atmosphere beneath a parachute. If it can be made capable of detecting phosphine at a few parts per billion, the case for sending it would become even stronger than it already is. The next mission to Venus, though, is not American but Indian: the Shukrayaan-1 orbiter is currently pencilled in for launch in 2023, which should be enough time to put on a phosphine-optimised instrument.

If you can make it here...Carl Sagan, who wrote a rather remarkable article about the possibility of balloon-like creatures in the clouds of Venus in the 1960s, is well remembered in astrobiological circles for the dictum that extraordinary claims require extraordinary evidence. Planetary observations are full of anomalies: you cannot invoke extraterrestrials willy nilly to explain them, creating what the astrobiologist David Grinspoon calls aliens of the gaps.

No one is yet claiming that there is life on Venus, and so the current evidence can get by simply by being intriguing, which it definitely is. But if it does turn out that the phosphine is biological, the first half of Sagans dictum will need re-examining, at least as far as the hunt for life is concerned.

Not that long ago scientists had pretty much given up on finding life anywhere in the solar system beyond Earth. Now astrobiologists are investigating the possibility of life on, in or above Saturns moon Titan, or in the ice covered ocean of one of the planets other moons, Enceladus. Jupiters moon Europa is also a possibility, as are various other bodies which may contain subsurface oceans. And there is always Mars.

If science finds life on or in any of those bodies, the idea that its presence is in itself extraordinary will take a knock. If they find it over hellish Venus as well, or instead, life will come to look yet less like an odd exception. Indeed, at the microbial level at least, life may turn out to be quite ordinary.

But that will make it no less wonderful. In some ways, it may make it more so.

More here:
Scientists find possible signs of life in the clouds of Venus - The Economist

I’m An Integrative MD & You Have To Stop Neglecting Neck Health – mindbodygreen.com

Many of us are taught to consider our heart health, and know that we should eat less red meat and work out to keep our ticker happy. However, very few of us have spent much time thinking about our neck health. That's a shame, because the truth is, your neck is home to many important structures in your body's system, including your spinal cord, thyroid, the vagus nerve, and more.

The vagus nerve is one of the master nerves that controls many functions in the body, and it exits your brain at the base of your skull and travels down through the neck. This nerve impacts a wide range of bodily functions, including your heart rate and blood pressure, breathing, liver function, digestion, hunger, mood and mental health, and immune system. So there are a huge number of issues that can occur if your vagus nerve malfunctions.

Continue reading here:
I'm An Integrative MD & You Have To Stop Neglecting Neck Health - mindbodygreen.com

Doctors Demand Integrative Medicine Be Incorporated Into National Health Policy – Scoop.co.nz

Wednesday, 16 September 2020, 6:05 amPress Release: Australasian Integrative Medicine Association

Integrative medicine specialists are lobbying theAustralian and New Zealand governments to incorporateintegrative medicine into national health policy.

Twoof Australasias leading integrative medicineorganisations ACNEM and AIMA have written to state andfederal health ministers requesting a meeting to discussinclusion of evidence-based, cost- effective interventionsto improve public health.

200 integrative doctors andmore than 400 health practitioners have signed the letterwhich requests the inclusion of integrative medicine totreat chronic disease and improve immunity.

The letterIntegrativeMedicine: Essential to support the fight against COVID-19requests a meeting with health departments tooutline the evidence supporting integrative healthtreatments in reducing inflammation and increasing immunity(such as Vitamin D and Zinc) in response to COVID-19.

Chronic diseases such as diabetes, cardiovasculardisease and hypertension are important co-factors in themorbidity of COVID-19 patients. The petition states poornutrition and micronutrient depletion to be common in theseconditions and urges the Government to consider improvedhealth directives to boost societal immune function toprotect people from COVID-19 and other emergingviruses.

We are doctors wanting the best possibleoutcomes for our patients based on evidence and individualcare, AIMA President Dr Penny Caldicottsaid.

Now is the time to offer up our resources,skills and research to support the community to buildresilience not only to COVID-19 but also to the many chronicdiseases affecting our health.

Integrative medicalpractice successfully combines evidence-based nutritional,environmental and conventional strategies to treat chronicdisease and improve patient immunity, two crucial co-factors in the fight against COVID-19.

ACNEM PresidentDr Ron Ehrlich said integrative medicine can better preparehumanity for the novel viruses of the 21stCentury:

Government must acknowledge the future ofhealthcare lies with an integrative medicine approach. Aninvestment in this approach is an investment in our economyand our future, he said.

We are wanting aconversation with the Government to improve the health ofall people. We want to build a society which cares deeplyabout health and wellbeing for future generations. Byworking collaboratively with medicine and science we canachieve the best outcomes forall.

Scoop Media

Become a member Find out more

The rest is here:
Doctors Demand Integrative Medicine Be Incorporated Into National Health Policy - Scoop.co.nz

Tulsi And Ashwagandha Green Tea May Help Beat Stress And Anxiety – Experts Reveal – NDTV Food

Tulsi and Ashwagandha are potent adaptogens and can be consumed in form of kadha or tea

Highlights

Every chai-lover will agree to this that there's hardly anything a cup of hot tea can't fix. From reconnecting with your friends and loved ones over chai to rejuvenating yourself at any time of the day, a perfectly brewed tea does it all! And if you wisely add some herbs and spices to it, then it might go a long way to benefit your health too. As per health experts around the world, herb and spice-infused tea (green, black or olong tea) have often been considered to be a natural remedy for several ailments. Two such popular traditional herbs are Tulsi (Holy Basil) and Ashwagandha (Indian Ginseng).

For the unversed, both Tulsiand Ashwagandha have been an important part of traditional medical practice since centuries. These herbs are potent adaptogens and can be consumed in form of kadha or tea. As per Macrobiotic Nutritionist and Health Practitioner Shilpa Arora ND, "Ashwagandhaand Tulsi help balance hormones. It isthe root cause for stress, fluctuations of mood andweight gain. Imbalance in hormone also reducesbody's energy levels."

We bring you a herbal tea recipe that includes Tulsi and Ashwagandha, along with green tea, which may do wonders for relieving stress and anxiety after a long tiring day.

Tulsiis dubbed to maintain the level of cortisol hormone (stress hormone) in the body. According to a recent study published in the Journal of Ayurveda and Integrative Medicine, basil is a potent source of antidepressant and anti-anxiety properties.

Also Read:Tulsi Haldi Dalchini Laung Kadha May Be The Ideal Drink To Have Right Now For Good Immunity

According to Consultant Nutritionist Rupali Dutta, "This traditional herb has anti-ageing and de-stressing properties. It is used to fight depression, anxiety and boost cognitive functioning. In this regard, one must remember that the ashwagandharoots have several medicinal properties and one can consume the roots in various forms."

Also Read:Healthy Diet: This Moon Milk At Night May Help Induce Good Sleep

Benefit of green tea is no secret to the world. Other than improving metabolism, promoting weight loss and boosting immune system, it is also known to have calming effects on our nerves. It is enriched with Theanine that helps to beat stress and anxiety. A research by the University of Shizuoka, Japan, found that the students who consumed green tea consistently experienced lower levels of stress.

Also Read:Adding Cinnamon, Turmeric To Green Tea May Help Boost Immunity, Weight Loss And Overall Health

1.5 cups of water

Half teaspoon Ashwagandha roots

3-4 Tulsi leaves

1 teaspoon green tea

Step 1. Boil the water for 2-3 minutes.

Step 2. Switch of the flame and add green tea, ashwagandha roots and Tulsi leaves. Close the lid and let it infuse for 10 minutes.

Step 3. Strain it in a cup and sip on.

(Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.)

About Somdatta SahaExplorer- this is what Somdatta likes to call herself. Be it in terms of food, people or places, all she craves for is to know the unknown. A simple aglio olio pasta or daal-chawal and a good movie can make her day.

Continued here:
Tulsi And Ashwagandha Green Tea May Help Beat Stress And Anxiety - Experts Reveal - NDTV Food

Exercise and Diet Are More Important Than Ever With Virus at Large – Medscape

If your life these days is anything like mine, a pre-pandemic routine that included regular exercise and disciplined eating has probably given way to sedentary evenings on a big chair, binge-watching reruns of your favorite TV series while guzzling chocolate ice cream or mac 'n' cheese.

But let's not beat ourselves up about it. Several doctors I spoke with recently said most of their patients and many of their colleagues are struggling to maintain healthy habits amid the anxiety of the pandemic. "The Quarantine 15" (pounds, that is) is a real phenomenon.

The double challenge of protecting our health, including our immune systems, while battling unhealthy temptations "is a struggle everyone is dealing with," says Dr. David Kilgore, director of the integrative medicine program at the University of California-Irvine.

Well before COVID-19, more than 40% of U.S. adults were obese, which puts them at risk for COVID-19's worst outcomes. But even people accustomed to physical fitness and good nutrition are having trouble breaking the bad habits they've developed over the past five months.

Karen Clark, a resident of Knoxville, Tennessee, discovered competitive rowing later in life, and her multiple weekly workouts burned off any excess calories she consumed. But the pandemic changed everything: She could no longer meet up with her teammates to row and stopped working out at the YMCA.

Suddenly, she was cooped up at home. And, as for many people, that led to a more sedentary lifestyle, chained to the desk, with no meetings outside the house or walks to lunch with colleagues.

"I reverted to comfort food and comfortable routines and watching an awful lot of Netflix and Amazon Prime, just like everybody else," Clark says. "When I gained 10 pounds and I was 25, I just cut out the beer and ice cream for a week. When you gain 12 pounds at 62, it's a long road back."

She started along that road in July, when she stopped buying chips, ice cream and other treats. And in August, she rediscovered the rowing machine in her basement.

But don't worry if you lack Clark's discipline, or a rowing machine. You can still regain some control over your life.

A good way to start is to establish some basic daily routines, since in many cases that's exactly what the pandemic has taken away, says Dr. W. Scott Butsch, director of obesity medicine at the Cleveland Clinic's Bariatric and Metabolic Institute. He recommends you "bookend" your day with physical activity, which can be as simple as a short walk in the morning and a longer one after work.

And, especially if you have kids at home who will be studying remotely this fall, prepare your meals at the beginning of the day, or even the beginning of the week, he says.

If you haven't exercised in a while, "start slow and gradually get yourself up to where you can tolerate an elevated heart rate," says Dr. Leticia Polanco, a family medicine doctor with the South Bay Primary Medical Group, just south of San Diego. If your gym is closed or you can't get together with your regular exercise buddies, there are plenty of ways to get your body moving at home and in your neighborhood, she says.

Go for a walk, a run or a bike ride, if one of those activities appeals to you. Though many jurisdictions across the United States require residents to wear masks when out in public, it may not be necessary and may even be harmful to some people with respiratory conditions while doing strenuous exercise.

"It's clearly hard to exercise with a mask on," says Dr. Yvonne Maldonado, a pediatrician specializing in infectious diseases at Stanford University's School of Medicine. "We go hiking up in the foothills and we take our masks with us and we don't wear them unless somebody starts coming the other way. Then we will put the mask on, and then we take it off and we keep going."

If you prefer to avoid the mask question altogether, think of your house as a cleverly disguised gym. Put on music and dance, or hula-hoop, Polanco suggests. You can also pump iron if you have dumbbells, or find a cable TV station with yoga or other workout programs.

If you search on the internet for "exercise videos," you will find countless workouts for beginners and experienced fitness buffs alike. Try one of the seven-minute workout apps so popular these days. You can download them from Google Play or the Apple Store.

If you miss the camaraderie of exercising with others, virtual fitness groups might seem like a pale substitute, but they can provide motivation and accountability, as well as livestreamed video workouts with like-minded exercisers. One way to find such groups is to search for "virtual fitness community."

Many gyms are also offering live digital fitness classes and physical training sessions, often advertised on their websites.

If group sports is your thing, you may or may not have options, depending on where you live.

In Los Angeles, indoor and outdoor group sports in municipal parks are shut down until further notice. The only sports allowed are tennis and golf.

In Montgomery County, Maryland, the Ron Schell Draft League, a softball league for men 50 and older, will resume play early this month after sitting out the spring season due to COVID-19, says Dave Hyder, the league's commissioner.

But he says it has been difficult to get enough players because of worries about COVID.

"In the senior group, you have quite a lot of people who are in a high-risk category or may have a spouse in a high-risk category, and they don't want to chance playing," says Hyder, 67, who does plan to play.

Players will have to stay at least 6 feet apart and wear masks while off the field. On the field, the catcher is the only player required to wear a mask. That's because masks can steam up glasses or slip, causing impaired vision that could be dangerous to base runners or fielders, Hyder explains.

Whatever form of exercise you choose, remember it won't keep you healthy unless you also reduce consumption of fatty and sugary foods that can raise your risk of chronic diseases such as obesity, diabetes and hypertension all COVID-19 risk factors.

Kim Guess, a dietitian at UC-Berkeley, recommends that people lay in a healthy supply of beans and lentils, whole grains, nuts and seeds, as well as frozen vegetables, tofu, tempeh and canned fish, such as tuna and salmon.

"Start with something really simple," she said. "It could even be a vegetable side dish to go with what they're used to preparing."

Whatever first steps you decide to take, now is a good time to start eating better and moving your body more.

Staying healthy is "so important these days, more than at any other time, because we are fighting this virus which doesn't have a treatment," says the Cleveland Clinic's Butsch. "The treatment is our immune system."

This KHN story first published on California Healthline, a service of the California Health Care Foundation.

Read the original here:
Exercise and Diet Are More Important Than Ever With Virus at Large - Medscape

Exercise and diet are more important than ever with COVID at large – Salon

If your life these days is anything like mine, a pre-pandemic routine that included regular exercise and disciplined eating has probably given way to sedentary evenings on a big chair, binge-watching reruns of your favorite TV series while guzzling chocolate ice cream or mac 'n' cheese.

But let's not beat ourselves up about it. Several doctors I spoke with recently said most of their patients and many of their colleagues are struggling to maintain healthy habits amid the anxiety of the pandemic. "The Quarantine 15" (pounds, that is) is a real phenomenon.

The double challenge of protecting our health, including our immune systems, while battling unhealthy temptations "is a struggle everyone is dealing with," says Dr. David Kilgore, director of the integrative medicine program at the University of California-Irvine.

Well before COVID-19, more than 40% of U.S. adults were obese, which puts them at risk for COVID-19's worst outcomes. But even people accustomed to physical fitness and good nutrition are having trouble breaking the bad habits they've developed over the past five months.

Karen Clark, a resident of Knoxville, Tennessee, discovered competitive rowing later in life, and her multiple weekly workouts burned off any excess calories she consumed. But the pandemic changed everything: She could no longer meet up with her teammates to row and stopped working out at the YMCA.

Suddenly, she was cooped up at home. And, as for many people, that led to a more sedentary lifestyle, chained to the desk, with no meetings outside the house or walks to lunch with colleagues.

"I reverted to comfort food and comfortable routines and watching an awful lot of Netflix and Amazon Prime, just like everybody else," Clark says. "When I gained 10 pounds and I was 25, I just cut out the beer and ice cream for a week. When you gain 12 pounds at 62, it's a long road back."

She started along that road in July, when she stopped buying chips, ice cream and other treats. And in August, she rediscovered the rowing machine in her basement.

But don't worry if you lack Clark's discipline, or a rowing machine. You can still regain some control over your life.

A good way to start is to establish some basic daily routines, since in many cases that's exactly what the pandemic has taken away, says Dr. W. Scott Butsch, director of obesity medicine at the Cleveland Clinic's Bariatric and Metabolic Institute. He recommends you "bookend" your day with physical activity, which can be as simple as a short walk in the morning and a longer one after work.

And, especially if you have kids at home who will be studying remotely this fall, prepare your meals at the beginning of the day, or even the beginning of the week, he says.

If you haven't exercised in a while, "start slow and gradually get yourself up to where you can tolerate an elevated heart rate," says Dr. Leticia Polanco, a family medicine doctor with the South Bay Primary Medical Group, just south of San Diego. If your gym is closed or you can't get together with your regular exercise buddies, there are plenty of ways to get your body moving at home and in your neighborhood, she says.

Go for a walk, a run or a bike ride, if one of those activities appeals to you. Though many jurisdictions across the United States require residents to wear masks when out in public, it may not be necessary and may even be harmful to some people with respiratory conditions while doing strenuous exercise.

"It's clearly hard to exercise with a mask on," says Dr. Yvonne Maldonado, a pediatrician specializing in infectious diseases at Stanford University's School of Medicine. "We go hiking up in the foothills and we take our masks with us and we don't wear them unless somebody starts coming the other way. Then we will put the mask on, and then we take it off and we keep going."

If you prefer to avoid the mask question altogether, think of your house as a cleverly disguised gym. Put on music and dance, or hula-hoop, Polanco suggests. You can also pump iron if you have dumbbells, or find a cable TV station with yoga or other workout programs.

If you search on the internet for "exercise videos," you will find countless workouts for beginners and experienced fitness buffs alike. Try one of the seven-minute workout apps so popular these days. You can download them from Google Play or the Apple Store.

If you miss the camaraderie of exercising with others, virtual fitness groups might seem like a pale substitute, but they can provide motivation and accountability, as well as livestreamed video workouts with like-minded exercisers. One way to find such groups is to search for "virtual fitness community."

Many gyms are also offering live digital fitness classes and physical training sessions, often advertised on their websites.

If group sports is your thing, you may or may not have options, depending on where you live.

In Los Angeles, indoor and outdoor group sports in municipal parks are shut down until further notice. The only sports allowed are tennis and golf.

In Montgomery County, Maryland, the Ron Schell Draft League, a softball league for men 50 and older, will resume play early this month after sitting out the spring season due to COVID-19, says Dave Hyder, the league's commissioner.

But he says it has been difficult to get enough players because of worries about COVID.

"In the senior group, you have quite a lot of people who are in a high-risk category or may have a spouse in a high-risk category, and they don't want to chance playing," says Hyder, 67, who does plan to play.

Players will have to stay at least 6 feet apart and wear masks while off the field. On the field, the catcher is the only player required to wear a mask. That's because masks can steam up glasses or slip, causing impaired vision that could be dangerous to base runners or fielders, Hyder explains.

Whatever form of exercise you choose, remember it won't keep you healthy unless you also reduce consumption of fatty and sugary foods that can raise your risk of chronic diseases such as obesity, diabetes and hypertension all COVID-19 risk factors.

Kim Guess, a dietitian at UC-Berkeley, recommends that people lay in a healthy supply of beans and lentils, whole grains, nuts and seeds, as well as frozen vegetables, tofu, tempeh and canned fish, such as tuna and salmon.

"Start with something really simple," she said. "It could even be a vegetable side dish to go with what they're used to preparing."

Whatever first steps you decide to take, now is a good time to start eating better and moving your body more.

Staying healthy is "so important these days, more than at any other time, because we are fighting this virus which doesn't have a treatment," says the Cleveland Clinic's Butsch. "The treatment is our immune system."

This KHN story first published onCalifornia Healthline, a service of the California Health Care Foundation.

Kaiser Health News (KHN) is a national health policy news service. It is an editorially independent program of the Henry J. Kaiser Family Foundation which is not affiliated with Kaiser Permanente.

Go here to see the original:
Exercise and diet are more important than ever with COVID at large - Salon

Crafted Energy Expands Distribution Network Through Partnership With Downeast Bicycle Specialists – Bicycle Retailer

September 15, 2020

PHOENIX, Ariz. Crafted Energy, a premiere functional energy bar brand based out of Phoenix, Arizona, has announced a partnership with Downeast Bicycle Specialists, a leading bike parts and accessories distributor and a subsidiary of the Hans Johnsen Company, increasing distribution channels to more easily reach consumers in the cycling and ancillary communities. This partnership gives dealers across the Northeast and US increased access to sport-specific functional energy.

"One thing we consistently hear from our retail partners is how their customers are looking for cleaner sources of performance nutrition," explains Ryan Naboshek, co-founder of Crafted Energy. "These athletes are seeking clean, real-food, and purposeful alternatives to fuel their performance, rather than the processed sugars traditionally found in today's gels, chews, and drinks. Ever since our early discussions with Downeast, we felt that their team both understood the value proposition of functional cycling nutrition and shared a common belief in its potential within the athletic community. We're thrilled to partner with Downeast as we collaboratively bring functional energy to those athletes in the northeast and across the US."

Along with this partnership, Crafted Energy has announced an increased commitment to making their sport-specific nutrition more accessible to athletes nationwide. Crafted Energy currently produces unique energy bars specially engineered to three core activities; cycling, running, and rock climbing. So, what makes their bars sport-specific? During the product development stage, the Crafted Energy team first pinpoints the unique energy and recovery needs of a sport. Then, they look for plant-based and clean label ingredients to meet the nutritional profile and holistic benefits that were identified in the first step of the process. Lastly, they tailor the texture and consistency of each bar to meet the digestive needs of that athletic pursuit to ensure optimal performance and recovery. The result is a nutrient-dense, sport-specific, plant-based, clean-label, and easy-to-digest functional energy bar. This unique development approach of curating and leveraging the holistic benefits of ingredients as a means of sport-tailored energy and recovery is the core concept behind functional energy. Rigorous athlete testing and an ethic that leaves no room for sacrifice in product development, quality ingredients, and formulation have made Crafted Energy a trusted source of performance nutrition by athletes nationwide.

The partnership between Downeast Bicycle Specialists and Crafted Energy is a big step forward in bringing functional energy to athletes seeking to improve their performance through proper, clean, and curated nutrition.

About Crafted Energy Crafted Energy came to fruition initially through separate, but simultaneous 'aha' moments between long-time friends Darshan Shah, MD & Zach Olschwanger and childhood friends, Ryan Naboshek & Zach Olschwanger in 2014. Leveraging Darshan Shah's extensive background in Integrative and Holistic Medicine and Zach's passion for clean sports nutrition, Crafted Energy began discussing ways in which they could address the functional nutrition and sport-specific gap in the otherwise crowded energy bar market. Crafted Energy wants to challenge the 'one-size-fits-all' energy bar and has developed products that are unique to specific activities because they understand that all activities require something different from the body. This represents the underlying theme that Crafted Energy continues to operate with today.

About Downeast Bicycle Specialists Downeast Bicycle Specialists is a full service bicycle parts and accessories distributor servicing independent bicycle dealers throughout the United States. Our annual catalog features thousands of items from over 100 manufacturers around the world. We offer same day shipping, competitive pricing, free freight, group and kit programs, and online ordering. We can ship with 1 to 3 day delivery anywhere in the continental United States and we have one of the highest fill rates in the industry. Our knowledgeable and friendly staff are all cycling enthusiasts. Most have extensive shop experience and can answer just about any technical question thrown at them. We support the bicycle industry and the sport we love through national and local advocacy.

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Crafted Energy Expands Distribution Network Through Partnership With Downeast Bicycle Specialists - Bicycle Retailer

Can Forsythia Cure Coronavirus? Herb With Antibacterial, Antiviral Properties Is Popular in TCM – International Business Times, Singapore Edition

Coronavirus contagion spreads by just talking

Forsythia is a plant that produces fruits called Lian Qiao, which has been used in traditional Chinese medicine (TCM) to help treat various symptoms including fever, nausea, swelling, and sore throat.

There is limited evidence to prove the forsythia's effectiveness. The Chinese Journal of Integrative Medicine suggests that Lian Qiao can be used to treat or prevent Coronavirus. The journal also lists Radix astragali (Huangqi), Radix glycyrrhizae (Gancao), Radix saposhnikoviae (Fangfeng), Rhizoma Atractylodis Macrocephalae (Baizhu) and Lonicerae Japonicae Flos (Jinyinhua) for Coronavirus treatment.

As of now the majority of studies on forsythia's medicinal properties were conducted either in animals or in vitro, performed with microorganisms, cells, or biological molecules outside their normal biological context. That is why there is very little scientific evidence on its effectiveness in humans. But from animal and vitro studies, scientists have found many properties that could help explain some of its benefits in traditional Chinese medicine (TCM).

A 2017 study found that in vitro dried Lian Qiao has shown a potential to combat bacteria such as staphylococcus aureus, Escherichia coli, and streptococcus, while a 2013 research revealed the effects of both forsythia and Japanese honeysuckle on the influenza virus, the researchers found that they both restrain the virus from multiplying and boost immune cell function.

A vitro study, which came in 2010 in the Journal of Medicinal Plant Research, said that the plant, mostly native to eastern Asia, could be effective against H1N1. As per another 2017 study, which was conducted on mice, forsythia has shown promising signs in treating intestinal inflammatory conditions like ulcerative colitis.

Forsythia has been studied in treating certain cancers. In a study published in Molecular Medicine Reports, esophageal cancer cells were put into mice, and researchers found that forsythia inhibited the growth of the cancer cells. But further study is needed to completely understand the effectiveness of this herb.

The Use of Natural Remedy

The name 'forsythia' may sound familiar because it was mentioned in the 2011 movie, "Contagion," which became highly popular during the Coronavirus pandemic. There is no solid proof that forsythia can be useful to treat or cure Coronavirus. But, for its antibacterial, anti-inflammatory, and antiviral properties, the plant is used in traditional Chinese medicine to treat bacterial and viral infections.

As per the experts, the safest and best way to take forsythia is to discuss dosage with an herbal medicine expert, as there is not enough and reliable information to know the side effects of this herb. The Food and Drug Administration (FDA) in the U.S. has not approved forsythia products.

Deborah Ann Ballard, MD, MPH, internal medicine doctor at Duke Integrative Medicine said she does not prescribe forsythia to her patients and does not recommend anyone to take forsythia without consulting a Traditional Chinese Medicine doctor. "Proper use of this or any remedy requires an individualized assessment and approach," she added.

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Can Forsythia Cure Coronavirus? Herb With Antibacterial, Antiviral Properties Is Popular in TCM - International Business Times, Singapore Edition

ASU, Dignity Health partner on interprofessional primary care education – ASU Now

September 15, 2020

In the latest move to advance theirpartnership of five years and counting, Arizona State University and Dignity Health have announced the launch of a new project to design, implement and evaluate a new model for interprofessional primary care education that will build in changes and lessons learned from COVID-19, including the dramatic increase in remote visits, telemedicine, new teamwork models and distance education.

Primary care is the hub of our health care system, saidGerri Lamb, an Edson College of Nursing and Health Innovation professor who serves as co-principal investigator along withDr. Keith Frey, chief medical officer at Dignity Health Arizona and a professor of practice at ASUs W. P. Carey School of Business.

Primary care providers and teams are responsible for prevention of illness, helping patients manage chronic illnesses and coordination across various health care settings.

Even before COVID, we were seeing signs that primary care needed some reenvisioning, Lamb said. Not only in terms of quality of care, but also in how we educate students.

Some of the signposts of the need for change she and Frey listed include primary care workforce shortages, diminishing numbers of new residents (according to Lamb and Frey, 2019 saw the lowest number of residents applying for primary care positions in decades) and a decline in the number of younger and middle-age people scheduling visits with their primary care providers.

What happens then is everybody all the sudden shows up in the emergency room or urgent care, overwhelming those resources, Frey said. So this is a system issue, from a regional and national level.

Another issue with the current system he and Lamb hope to address is the lack of emphasis on interprofessional education.

We already know that when you're done with your training, your work environment is going to be a team sport, and yet historically, we don't train people together very well, Frey said. So the idea behind this is to create an environment where we can get the trainees physicians, advanced-practice nurses, physician assistants, behavioral health professionals, registered nurses and all members of the health care team to learn health care in a more integrative model.

Funded by a $525,000 grant from theASU Dignity Health Collaborative Strategic Initiatives Program, phase one of the Transforming the Primary Care Workforce project began Sept. 1 and will last 18 months, during which project investigators will conduct focus groups and stakeholder interviews, hold advisory meetings, and make facility site visits to design, test and analyze the new model for integrated primary care practice and education.

The way the project is framed is we are doing this with and from and about the stakeholders, Lamb said. Patients, families, students and providers. We will be inviting them and celebrating them at the table as our advisers in this. They know what they need, so we're going to listen to them, and were going to create something that works for them.

She and Frey had been discussing the possibility of such a project for some time when the opportunity arose for Dignity to create a new family medicine residency in the East Valley, a region of the Phoenix metropolitan area that is swiftly growing, making physician shortages even more acute. The decision to partner on the venture was a natural one.

Rather than set up a program on our own, we thought why not partner with colleagues who I've known for many years at ASU, like Gerri Lamb, who are national thought leaders in this space, Frey said. Why not stack hands, come together and build on this partnership that we already have enjoyed for several years and see if we can reconceptualize a new model that will get us where we always wanted to go.

Susan Pepin, ASUs managing director of health and clinical partnerships, praised Dignity Health in turn for its commitment to the communities it serves.

As a health system, they really care about the social determinants of peoples health and meeting people in underserved populations, she said. Theyre not a hospital on a hill. They really reach out into the community and want to make a difference.

Indeed, the purpose of this new model of interprofessional training is not only to prepare outstanding practitioners to deliver top quality care, but to attract top students who will stay in Arizona.

Keith has a vision for this, Lamb said. And his vision was very aligned with my vision for what was possible, and with Edson's vision, in terms of a community partnership and doing meaningful work while also addressing workforce issues.

They expect residents of the new program to begin in the summer of 2023, once the soon-to-be-developed clinical learning environment program has been tested and evaluated.

The project includes co-investigators from ASUs College of Health Solutions:Kristen Will, a clinical associate professor and current chair of the steering committee for the National Collaborative for Improving the Clinical Learning Environment (NCICLE); andBradley Doebbeling, professor of the science of health care delivery and biomedical informatics. It also involves collaboration between ASUsCenter for Advancing Interprofessional Practice, Education and Research(CAIPER) and ASUsCenter for Innovation in Healthy and Resilient Aging(CIHRA).

Of the many social determinants of health that the COVID-19 pandemic has laid bare, those that affect Arizonas aging population will be the main focus of phase one of Transforming the Primary Care Workforce. Later phases will examine others, such as poverty, racial inequities and food insecurity.

According to David Coon,CIHRA director and associate dean of research at Edson College, the pandemic has highlighted issues already of concern for older adults, such as social isolation and loneliness, and also raised awareness of the importance of telemedicine. Furthermore, he believes there should be more emphasis on the role of caregivers in the wellness and health outcomes of older adults.

As our society continues to age, we really need to be thinking about how we can up the game of the primary care workforce and prepare them to work with older adults and their family members and caregivers, because theyre not always seen as a part of that interprofessional care team, but they are critical members, Coon said.

If patient experience and outcomes are one half of the Transforming the Primary Care Workforce project, provider well-being is the other.

The amount of burnout in nurses and physicians and students is shocking, Lamb said. And COVID is making it worse. So there's huge need not only to reenvision primary care from a practice and learning perspective, but also because we really need to pay attention to the well-being of providers. All of that is part of this project.

Top photo courtesy of Pixabay

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ASU, Dignity Health partner on interprofessional primary care education - ASU Now

Are we mapping a path to CRISPR babies? | TheHill – The Hill

In November 2018, at a gene-editing summit hosted by scientific societies from the U.S., the U.K., and Hong Kong, a Chinese researcherannouncedthat he had created the worlds first genetically modified babies.He Jiankuifully expected to be celebrated for a scientific breakthrough; hementionedthe Nobel Prize. Instead, he was almost universally condemned.

Key figures associated with theU.S. National AcademiesandU.K. Royal Societyjoined in thecriticismbut did not reject heritable genome editing. Instead, they objected to the Chinese researchers timing. It was too soon, they said. It hadnt been done as they thought it should have been. But according to the researcher now being called a rogue, it was theNational Academies 2017 reportthat had given him the green light for his experiments.

In the aftermath of this headline-grabbing debacle, the scientific societies decided on a do-over. They declared it time to define a rigorous, responsible translational pathway toward clinical use of heritable genome editing. Theyset upa carefully selectedinternational commissionwith themandateto map the scientific details ofhowdesigner-baby technology could be brought to the fertility clinic.

This mandate was flawed from the start. The idea that now is the time to set aside the deeply controversial question ofwhetherheritable genome editing should be done at all so that a small group of experts can settle the nitty-gritty details ofhowit should take place is entirely backward. It flies in the face of the widely shared acknowledgment that scientists alone cannot make this decision; that we must have wide-ranging and inclusive public discussions aimed at buildingbroad societal consensus. It undermines policies in some70 countriesaround the world that prohibit heritable genome editing. And its a slap in the face to the manyscientists,biotech executives,human rights and social justice advocates, and others who support a moratorium or ban on altering the human germline.

The commissions 225-pagereport, released on Sept. 3, does have some strong points. It is more cautious than the previous report, recommending that heritable genome editing should initially be allowed only in the exceedingly rare cases where embryo screening for severe genetic conditions would not be an option. And it paints a vivid picture of the significant technical hurdles facing those eager to pursue heritable human genome editing: shortfalls in the editing tools, in the technologies necessary to test safety and efficacy, even in our understanding of the genetics underlying most heritable diseases.

These findings ought tolay to restthe unfounded assumption that engineering the genomes of human embryos will soon be safe and effective. But even the most cautious considerations of technical safety cant stand-in for the fundamental point that the decision about whether to allow heritable genome editing should be driven by our values, not settled by the science.

The commission claims they are not endorsing heritable genome editing, merely constructing maps of the technological path in case a country should wish to use them. At best, this puts the cart before the horse and sends both horse and cart down a one-way road.

Heritable genome editing cant be separated from its real-world consequences. There are already clear signs that legalizingit would lead to reproductive tourism, jurisdiction shopping, andmission creep. As an example, the U.K.sapprovalof so-called mitochondrial donation for a small number of women with certain mitochondrial DNA diseases wasquickly followedby fertility clinics inUkraine,Spain, and Greeceoffering this high-risk technique, with no evidence of effectiveness, for general and age-related infertility.

A similar trajectory is all too easy to foresee if heritable genome editing is approved, even for limited circumstances. Especially where fertility services are offered on a for-profit basis, its unlikely that any boundaries would hold. We could soon see fertility clinics marketing genetically upgraded embryos, tempting parents-to-be with ads about giving their child the best start in life. From there, a normalized system of market-based eugenics could emerge, exacerbating already existing discrimination, inequality, and conflict.

Amid our multiple ongoing crises, it would be easy to overlook another report on still speculative biotechnology. But this one represents a profoundly consequential step, one that tries to settle in advance the coming decision about whether to engineer genes and traits passed on to future children and generations. Its another attempt to focus discussion on the science, while minimizingthe complex social realities in which scientific and technological developments unfold.

KatieHassonis program director on genetic justice andMarcyDarnovskyis executive director of theCenter for Genetics and Society,a non-profit organization based in Berkeley, California that works to encourage responsible uses and effective governance of human genetic and assisted reproductive technologies.

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Are we mapping a path to CRISPR babies? | TheHill - The Hill

Illuminating the opaque pathways of depression – MSUToday

Depression is a dark horse.

The disease often goes unnoticed, but affects work performance, social interaction and the ability to take pleasure in everyday life. According to theNational Center for Biotechnology Information, antidepressants only help around 50 percent of those who struggle with depression and anxiety and, even when they are effective, scientists have yet to understand how they work in the brain.

MSU associate professor of physiology A.J. Robison and his lab used new CRISPR-based technology to uncover pathways of depression-like behavior in the mouse brain. Credit: College of Natural Science

But groundbreaking research in the lab of Michigan State University scientistA.J. Robison, associate professor in theDepartment of Physiologyand MSUsNeuroscience Program, is directing some new rays of light onto the molecular, cellular and circuit-level mechanisms underlying depression-like diseases.

Theresultswere recently published inNature Communications.

In this paper, we perform the first ever CRISPR-based gene editing [a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified] in a single circuit between two areas of the mouse brain, explained Robison about the culmination of five years of research funded by the National Institutes of Mental Health. We can reach into the mouse brain and manipulate specific genes in a circuit involved in depression and anxiety-like behaviors a critical advance on the road to genetic medicine for psychiatric diseases.

Scientists estimate there are roughly 80-100 billion neurons connecting regions of the brain. To accomplish the feat of locating and manipulating a single gene in a single circuit required new and sophisticated technology. With the expertise of co-author Rachael Neve, director of theGene Transfer Core at Massachusetts General Hospital, they developed it.

The key advance is that we designed a dual-vector system to manipulate a specific gene in the connections between two brain areas, and that has never been done before, Robison said.

Cross section of a mouse brain. The projections of the cells between the vHPC and NAc, shown here in neon green, are manipulated by the new CRISPR viral vector-based technology developed by Rachael Neve and the Robison Lab. Credit: Andrew Eagle

The neurons that Robison and his team zeroed in on originate in the ventral hippocampus (vHPC), a deep-seated structure that projects to regions in the brain important in stress susceptibility, mood and social avoidance. Neurons rooted in the vHPC reach out with branch-like structures called axons to connect with the nucleus accumbens, or NAc. The completed circuit is regulated by the star of the pioneering paper, the transcription factor known as DFosB.

Using the viral vector technology specifically designed and packaged by Neve, the team split the CRISPR system in half. Half of the system, inert on its own, was an enzyme that can mutate DNA in the vHPC. The other half, a guide RNA, was sent to all cells that project to the NAc and tells the enzyme where to bind and the specific gene to mutate. Only those cells specific to the circuit from the vHPC to the NAc got both halves, triggering the enzyme to bind with and turn off a single gene: FosB.

When the FosB gene was turned off in the neurons, we were able to get a circuit-specific behavioral effect relevant to a disease like depression, said Robison about the landmark discovery. When we put it back, or rescued it within the circuit, the effect was erased.

Claire Manning was a key contributor to the groundbreaking study and is now a postdoctoral researcher at Stanford University. Credit: Ken Moon

One of the most exciting findings from our investigations was the circuit-specific role of the FosB protein in conferring resilience to stress, Eagle said. We also discovered that FosB altered the excitability of hippocampal circuit neurons and may be affecting long-term downstream changes that lead to changes in the activity of this circuit. But removing DFosB permanently altered the expression of a suite of genes, in effect removing the conductor from the orchestra. To that end, the paper goes on to report in-depth experiments on DFosB largely done by the members of theRobison Labincluding co-first authorsClaire Manning, a 2019 neuroscience graduate, now a postdoc at Stanford University; andAndrew Eagle, a former postdoctoral researcher, now an assistant professor in the MSU Department of Physiology.

Andrew Eagle, shown here imaging a mouse brain, played a major role in conducting experiments to further probe the function of DFosB. Credit: Research@MSU.

Based on the findings in the paper, the Robison Lab will continue to develop highly collaborative and cutting-edge techniques, accelerated by MSUs newly completed Interdisciplinary Science and Technology Building. This work is important because it elucidates a potential mechanism, namely FosB, for how stress may contribute to depression, Eagle continued. Future clinical work may find ways to directly manipulate FosB, or more likely one of its gene targets, to provide resilience to stress and decrease the incidence of depression in vulnerable people.

The end of this paper, which shows us measuring the changes of expression in hundreds of genes when we remove DFosB, is only the beginning of years of work for our lab, Robison said. Which genes are important and what are they doing in the brain? This is the challenge of a lifetime for me and my lab.

This article is repurposed content originally featured on the College of Natural Sciences website.

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Illuminating the opaque pathways of depression - MSUToday

Long-term functional data from Sarepta Therapeutics’ Most Advanced Gene Therapy Programs to be Presented at Upcoming Annual Congress of the World…

-- Webcast conference call to be held on Monday, Sept. 28, 2020 at 8:30 a.m. Eastern Time --

-- Additional poster presentations at WMS will highlight data from Sareptas RNA and gene therapy programs --

CAMBRIDGE, Mass., Sept. 14, 2020 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that new data from its most advanced gene therapy programs will be presented at the WMS25 Virtual Congress, the 25th International Annual Congress of the World Muscle Society, being held Sept. 28 Oct. 2.

Sarepta will host a webcast and conference call on Monday, Sept. 28, 2020 at 8:30 a.m. ET, to discuss the results, which include two-year functional data from Study 101 of SRP-9001 for Duchenne muscular dystrophy and 18-month functional results from Cohort 1 in the study of SRP-9003 for Limb-girdle muscular dystrophy Type 2E.

This will be webcast live under the investor relations section of Sarepta's website at https://investorrelations.sarepta.com/events-presentationsand will be archived there following the call for one year. Please connect to Sarepta's website several minutes prior to the start of the broadcast to ensure adequate time for any software download that may be necessary. The conference call may be accessed by dialing (844) 534-7313 for domestic callers and (574) 990-1451 for international callers. The passcode for the call is 6793650. Please specify to the operator that you would like to join the "Long-term Functional Data from Sareptas Gene Therapy Programs call.

In total, Sarepta will present 16 abstracts at this years meeting. All posters will be available on-demand throughout the Congress beginning on Monday, Sept. 28 at 7:00 a.m. EST. The full WMS25 Virtual Congress program is available here: https://www.wms2020.com/programme/.

Gene Therapy:

RNA Platform:

Natural history and other presentations:

Presentations will be archived under the events and presentations section of the Sarepta Therapeutics website at http://www.sarepta.comforone year following their presentation at WMS25.

AboutSarepta TherapeuticsAt Sarepta, we are leading a revolution in precision genetic medicine and every day is an opportunity to change the lives of people living with rare disease. The Company has built an impressive position in Duchenne muscular dystrophy (DMD) and in gene therapies for limb-girdle muscular dystrophies (LGMDs), mucopolysaccharidosis type IIIA, Charcot-Marie-Tooth (CMT), and other CNS-related disorders, with more than 40 programs in various stages of development. The Companys programs and research focus span several therapeutic modalities, including RNA, gene therapy and gene editing. For more information, please visitwww.sarepta.com or follow us on Twitter, LinkedIn, Instagram and Facebook.

Internet Posting of Information

We routinely post information that may be important to investors in the 'For Investors' section of our website atwww.sarepta.com. We encourage investors and potential investors to consult our website regularly for important information about us.

Source: Sarepta Therapeutics, Inc.

Sarepta Therapeutics, Inc.

Investors: Ian Estepan, 617-274-4052, iestepan@sarepta.com

Media: Tracy Sorrentino, 617-301-8566, tsorrentino@sarepta.com

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Long-term functional data from Sarepta Therapeutics' Most Advanced Gene Therapy Programs to be Presented at Upcoming Annual Congress of the World...

Treatment with RNA-Targeting Gene Therapy Reverses Molecular and Functional Features of Myotonic Dystrophy Type 1 in Mice – PRNewswire

SAN DIEGO, Sept. 14, 2020 /PRNewswire/ -- Locanabio, Inc., a leader in RNA-targeted gene therapy, today announced that results from a preclinical study of the company's therapeutic systems for the potential treatment of myotonic dystrophy type 1 (DM1) were published in Nature Biomedical Engineering. For the full article, titled "The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy," please visit: https://www.nature.com/articles/s41551-020-00607-7

Scientists at Locanabio, working with academic collaborators at UC San Diego School of Medicine and the University of Florida, assessed whether an RNA-targeting CRISPR Cas9 system (RCas9) could provide molecular and functional rescue of dysfunctional RNA processing in a DM1 mouse model. The RCas9 system was administered with one dose of an AAV gene therapy vector. Results in both adult and neonatal mice and using both intramuscular and systemic delivery showed prolonged RCas9 expression even at three months post-injection with efficient reversal of molecular (elimination of toxic RNA foci, MBNL1 redistribution, reversal of splicing biomarkers) and physiological (myotonia) features of DM1.Importantly, there were no significant adverse responses to the treatment.

"These results are consistent with earlier findings from several in vitro studies in muscle cells derived from DM1 patients published by Locanabio's scientific co-founder Dr. Gene Yeo of UC San Diego and further indicate the significant potential of our RNA-targeting gene therapy as a DM1 treatment," said Jim Burns, Ph.D., Chief Executive Officer at Locanabio. "Data show that our RNA-targeting system is able to destroy the toxic RNA at the core of this devastating genetic disease and thereby correct the downstream molecular and biochemical changes that result in myotonia, which is a hallmark symptom of DM1. We are pleased that Nature Biomedical Engineering recognizes the value of these preclinical data and we look forward to further advancing this developmental program to the benefit of DM1 patients."

"Currently available treatments for DM1 can improve specific symptoms but do not target the underlying biology and cause of the disease. These data demonstrate that RNA-targeting systems may efficiently and specifically eliminate toxic RNA repeats that cause DM1 and potentially lead to a more effective treatment option for patients," said Dr. Yeo. "The results also indicate that RNA-targeting gene therapy has potential applications in the treatment of other diseases, such as Huntington's disease and certain genetic forms of ALS, which are also caused by a buildup of toxic RNA repeats."

These studies were funded in part by the Muscular Dystrophy Association (MDA). "We are delighted to support Locanabio's recent work in myotonic dystrophy. These preclinical results represent a promising advance and a novel scientific approach for a group of patients who represent a major unmet medical need," said Sharon Hesterlee, Ph.D., Chief Research Officer, MDA.

About Locanabio, Inc.

Locanabio is the global leader in developing a new class of genetic medicines. Our unique and multi-dimensional approach uses gene therapy to deliver RNA binding protein-based systems to correct the message of disease-causing RNA and thereby change the lives of patients with devastating genetic diseases. These broad capabilities delivered via gene therapy enable Locanabio to potentially address a wide range of severe diseases with a single administration. The company is currently advancing programs in neuromuscular, neurodegenerative and retinal diseases. For more information, visit http://www.locanabio.com.

About Myotonic Dystrophy

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disorder affecting skeletal muscle, cardiac muscle, the gastrointestinal tract, and the central nervous system. DM1 is caused by a mutation in the myotonic dystrophy protein kinase (DMPK) gene. This mutation leads to a repeat expansion of the CTG (cytosine-thymine-guanine) trinucleotide. The expanded CTG is transcribed into toxic CUG (cytosine-uracil-guanine) repeats in the DMPK messenger RNA (mRNA). These toxic mRNA repeats lead to disease symptoms including progressive muscle wasting, weakness and myotonia (delayed relaxation of skeletal muscle), a hallmark of DM1. The incidence of myotonic dystrophy has historically been estimated at one in 8,000 individuals worldwide or approximately 40,000 people in the United States.

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Treatment with RNA-Targeting Gene Therapy Reverses Molecular and Functional Features of Myotonic Dystrophy Type 1 in Mice - PRNewswire

Sarepta Therapeutics Provides Program Update for SRP-9001, its Investigational Gene Therapy for the Treatment of Duchenne Muscular Dystrophy -…

CAMBRIDGE, Mass., Sept. 09, 2020 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that it has completed a Type C written response only meeting with the Office of Tissues and Advanced Therapies (OTAT), part of the Center for Biologics Evaluation and Research (CBER) at the U.S. Food and Drug Administration (FDA), to obtain OTATs concurrence on the commencement of its next clinical trial for SRP-9001 using commercial process material. SRP-9001 (AAVrh74.MHCK7.micro-dystrophin) is Sareptas investigational gene transfer therapy for the treatment of Duchenne muscular dystrophy.

Among other items, OTAT has requested that Sarepta utilize an additional potency assay for release of SRP-9001 commercial process material prior to dosing in a clinical study. Sarepta has several existing assays and data that it believes could be employed in response to OTATs request. However, additional dialogue with the Agency is required to determine the acceptability of the potency assay approach.

We look forward to working with OTAT to potentially satisfy their requests and to obtain clarity on the timing of the commencement of our commercial supply study. We will provide further updates as we are able, said Doug Ingram, president and chief executive officer, Sarepta Therapeutics. Every day, thousands of children degenerate from the irreversible damage caused by Duchenne muscular dystrophy. It is for that reason that we will work relentlessly with the Division to satisfy any requests of OTAT and continue the advancement of a potentially transformative therapy for these patients.

About SRP-9001 (AAVrh74.MHCK7.micro-dystrophin)SRP-9001 is an investigational gene transfer therapy intended to deliver the micro-dystrophin-encoding gene to muscle tissue for the targeted production of the micro-dystrophin protein. Sarepta is responsible for global development and manufacturing for SRP-9001 and plans to commercialize SRP-9001 in the United States. In December 2019, the Company announced a licensing agreement granting Roche the exclusive right to launch and commercialize SRP-9001 outside the United States. Sarepta has exclusive rights to the micro-dystrophin gene therapy program initially developed at the Abigail Wexner Research Institute at Nationwide Childrens Hospital.

AboutSarepta TherapeuticsAt Sarepta, we are leading a revolution in precision genetic medicine and every day is an opportunity to change the lives of people living with rare disease. The Company has built an impressive position in Duchenne muscular dystrophy (DMD) and in gene therapies for limb-girdle muscular dystrophies (LGMDs), mucopolysaccharidosis type IIIA, Charcot-Marie-Tooth (CMT), and other CNS-related disorders, with more than 40 programs in various stages of development. The Companys programs and research focus span several therapeutic modalities, including RNA, gene therapy and gene editing. For more information, please visitwww.sarepta.com or follow us on Twitter, LinkedIn, Instagram and Facebook.

Sarepta Forward-Looking Statements

This press release contains "forward-looking statements." Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "will," "intends," "potential," "possible" and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements regarding Sareptas belief that its existing assays and data could be employed in response to OTATs request; the acceptability of Sareptas potency assay approach by the FDA; our plan to work with OTAT to potentially satisfy their requests and to obtain clarity on the timing of the commencement of our commercial supply study; and the potential of SRP-9001 to be a transformative therapy for DMD patients.

These forward-looking statements involve risks and uncertainties, many of which are beyond Sareptas control. Known risk factors include, among others: delays in the commencement of Sareptas next clinical study for SRP-9001 could delay, prevent or limit our ability to gain regulatory approval for SRP-9001; any inability to complete successfully clinical development could result in additional costs to Sarepta or impair Sareptas ability to generate revenues from product sales, regulatory and commercialization milestones and royalties; SRP-9001 may not result in a viable treatment suitable for commercialization due to a variety of reasons, including the results of future research may not be consistent with past positive results or may fail to meet regulatory approval requirements for the safety and efficacy of product candidates; Sarepta may not be able to execute on its business plans and goals, including meeting its expected or planned regulatory milestones and timelines, clinical development plans, and bringing its product candidates to market, due to a variety of reasons, many of which may be outside of Sareptas control, including possible limitations of company financial and other resources, manufacturing limitations that may not be anticipated or resolved for in a timely manner, regulatory, court or agency decisions, such as decisions by the United States Patent and Trademark Office with respect to patents that cover Sareptas product candidates and the COVID-19 pandemic; and those risks identified under the heading Risk Factors in Sareptas most recent Annual Report on Form 10-K for the year ended December 31, 2019, and most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) as well as other SEC filings made by Sarepta which you are encouraged to review.

Any of the foregoing risks could materially and adversely affect Sareptas business, results of operations and the trading price of Sareptas common stock. For a detailed description of risks and uncertainties Sarepta faces, you are encouraged to review the SEC filings made by Sarepta. We caution investors not to place considerable reliance on the forward-looking statements contained in this press release. Sarepta does not undertake any obligation to publicly update its forward-looking statements based on events or circumstances after the date hereof.

Internet Posting of Information

We routinely post information that may be important to investors in the 'For Investors' section of our website atwww.sarepta.com. We encourage investors and potential investors to consult our website regularly for important information about us.

Source: Sarepta Therapeutics, Inc.

Sarepta Therapeutics, Inc.

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Sarepta Therapeutics Provides Program Update for SRP-9001, its Investigational Gene Therapy for the Treatment of Duchenne Muscular Dystrophy -...

10x Genomics First to Market With Product to Simultaneously Capture Epigenome and TranscriptomeChromium Single Cell Multiome ATAC + Gene Expression…

PLEASANTON, Calif., Sept. 15, 2020 (GLOBE NEWSWIRE) --10x Genomics (Nasdaq: TXG) today announced it has begun shipping its Chromium Single Cell Multiome ATAC + Gene Expression solution to customers, marking the first commercial release of a product capable of simultaneously profiling the epigenome and transcriptome from the same single cell. This multi-omic approach provides customers with the ability to link a cells epigenetic program to its transcriptional output, enabling a better understanding of cell functionality and bypassing the need to infer relationships through computer simulations.

This is one of our most ambitious undertakings at the company, said Ben Hindson, co-founder and Chief Scientific Officer of 10x Genomics. By introducing the first solution that captures ATAC and gene expression simultaneously, researchers can gain even more clarity by combining two already powerful methods to profile biological systems at single cell resolution simultaneously for the first time.

The new solution builds on an array of new products launched by the company this year for both its Chromium platform for single cell analysis as well as its Visium platform for spatial genomics. Early customers already working with Chromium Single Cell Multiome ATAC + Gene Expression include Stanford University School of Medicine, Icahn School of Medicine at Mt. Sinai and Spains Centro Nacional de Anlisis Genmico.

My lab is interested in understanding why some immune cell types fail to fight the cancer, said Dr. Ansuman Satpathy, Assistant Professor of Pathology, Stanford University School of Medicine. We plan to use 10x Genomics' new assay to understand the epigenetic and transcriptional regulation of immune cell dysfunction directly in patient samples, and to use this information to precisely engineer more effective immunotherapies in the future.

Until now, we have relied on computational prediction to match a cell's epigenome to a single-cell gene expression profile, said Dr. Holger Heyn, leader of the single cell genomics team at Spains Centro Nacional de Anlisis Genmico that is working on delineating the dynamics underlying B-cell differentiation and activation. 10x Genomics new multiome assay will allow us to directly measure what before could only be predicted, and offers a new gold standard that will confirm how accurate these predictions had been.

"With this new technology, we can better understand the mechanisms affected by the non-coding risk genetic variation across a wide range of neuropsychiatric diseases, including Alzheimers, Parkinsons, Schizophrenia, bipolar disorder and major depression, along with different severity of neuropathology and clinical symptomatology," added Dr. Panagiotis Roussos, Associate Professor of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai.

By using Chromium Single Cell Multiome ATAC + Gene Expression, researchers can:

Chromium Single Cell Multiome ATAC + Gene Expression is shipping to customers. To learn more, visit https://www.10xgenomics.com/products/single-cell-multiome-atac-plus-gene-expression.

About 10x Genomics10x Genomics is a life science technology company building products to interrogate, understand and master biology to advance human health. The companys integrated solutions include instruments, consumables and software for analyzing biological systems at a resolution and scale that matches the complexity of biology. 10x Genomics products have been adopted by researchers around the world including 97 of the top 100 global research institutions and 19 of the top 20 global pharmaceutical companies, and have been cited in over 1,500 research papers on discoveries ranging from oncology to immunology and neuroscience. The companys patent portfolio comprises more than 775 issued patents and patent applications.

Forward Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements generally can be identified by the use of forward-looking terminology such as may, will, should, expect, plan, anticipate, could, intend, target, project contemplate, believe, estimate, predict, potential or continue or the negatives of these terms or variations of them or similar terminology. These forward-looking statements include statements regarding 10x Genomics, Inc.s partnership activities, which involve risks and uncertainties that could cause 10x Genomics, Inc.s actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on managements current expectations, forecasts, beliefs, assumptions and information currently available to management, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect 10x Genomics, Inc.s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. The forward-looking statements in this press release are based on information available to 10x Genomics, Inc. as of the date hereof, and 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing 10x Genomics, Inc.s views as of any date subsequent to the date of this press release.

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ContactsMedia:media@10xgenomics.comInvestors:investors@10xgenomics.com

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10x Genomics First to Market With Product to Simultaneously Capture Epigenome and TranscriptomeChromium Single Cell Multiome ATAC + Gene Expression...

Scientists uncover essential role of one gene in antibody production – UBC Faculty of Medicine

Scientists from UBCs faculty of medicine and the Institute of Molecular Biology of the Austrian Academy of Sciences (IMBA) have discovered that the gene, known as JAGN1, plays an important role in antibody production and the bodys ability to mount a defense against pathogens, including viruses.

The findings were published online today in the Journal of Experimental Medicine.

Dr. Josef Penninger

Antibodies play a fundamental role in medicine, and antibody-mediated immune response is the ultimate target in the quest for a vaccine to defeat the current pandemic, says the studys senior author Dr. Josef Penninger, a professor in the department of medical genetics and director of the Life Sciences Institute at UBC and a researcher at IMBA.

As part of their investigation, Dr. Penningers research groups at UBC and IMBA shed light on the role of JAGN1 in relation to B cells, which are white blood cells that can develop into plasma cells when they recognize foreign substances, such as chemicals, bacteria, viruses and pollen. In their plasma cell form, B cells can produce thousands of antibodies per second that target a specific intruder. This production occurs at a location within the cell known as the endoplasmic reticulum.

When we knocked out JAGN1 in B cells of mice, we were able to measure a drastic reduction in the number of antibodies, says the studys first author Dr. Astrid Hagelkruys, a senior research associate at IMBA.

The researchers also found that the altered sugar molecules, which coat antibodies, facilitate an antibodys ability to bind to other immune cells, thereby strengthening the bodys defensive reaction.

JAGN1 seems to influence the antibody factories in the cells, says Dr. Penninger. To our surprise, this change in the sugar structure also leads to a better ability of the antibodies to bind to other immune cells and strengthens the defense reaction.

The scientists were able to demonstrate this mechanism in human samples.

Rare genetic defects occur in only a handful of people, but they can sometimes help us decipher basic principles of biology, adds Dr. Penninger. In this case, we were able to prove that a certain gene affects the endoplasmic reticulum and is therefore essential for the mass production of antibodies.

The gene JAGN1 had been previously identified as a player in the bodys immune system by the Penninger lab in collaboration with the Klein lab at Ludwig Maximilian University in Munich among patients with severe congenital neutropenia (SCN)a disease caused by a mutation in the JAGN1 gene. Patients with SCN have abnormally low levels of white blood cells called neutrophils, and suffer from serious infections because their immune systems cannot effectively kill off bacterial or fungal invaders.

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Scientists uncover essential role of one gene in antibody production - UBC Faculty of Medicine