Church, anti-abortion groups seen threatening women’s health bill – Thomson Reuters Foundation

By Nita Bhalla

NAIROBI, Sept 18 (Thomson Reuters Foundation) - Anti-abortion and church groups in Kenya are spreading false information about a bill to tackle teenage pregnancy and maternal death, women's rights campaigners said on Friday, warning that lawmakers could be influenced and vote against it.

The Reproductive Healthcare Bill, which is set to be sent to the Senate for debate in the coming days, includes provisions for sex education in schools, assisted reproduction such as surrogacy, and access to safe abortion services when necessary.

"If this legislation is not approved, teenage pregnancies, school dropouts, maternal mortality will all get worse," said Stephanie Musho, a human rights lawyer, specialising in sexual and reproductive health issues.

"There has been a lot of false information being put out about the bill which is not helpful," said Musho, adding that this could influence Kenya's male-dominated upper house of parliament.

A similar bill was brought before the Senate in 2014, but failed to pass. If the bill passes in the Senate, it will then go to the National Assembly - or lower house - to be voted on, she said.

Some anti-abortion and faith groups in the mainly Christian nation have said the legislation normalises underage sex and would allow LGBT+ people to have children through surrogacy, something women's groups say is not contemplated in the bill.

Critics of the proposed law say it also promotes widespread abortion, which is only permitted under Kenya's constitution when a woman's life or health is in danger and emergency treatment is required.

The bill would not change that, women's groups say, but could save the lives of thousands of women who die from botched abortions in backstreet clinics.

An estimated2,600 women and girls die annually in Kenya from complications related to unsafe abortions, according to Health Ministry data. That accounts for 35% of all maternal deaths.

The bill also stipulates that every health care provider is obliged to provide family planning services to women who need them and directs authorities to provide free antenatal care, delivery care and postnatal care for all women and girls.

Plans for the provision of sex education for children aged 10-17 and for adolescents to be able to access sexual and reproductive health services would help reduce high rates of unwanted teenage pregnancy, women's groups say.

According todata from the United Nations children's agency, UNICEF, more than 23% of Kenyan girls get pregnant before they are 18.

No date has been set for the bill to be sent to the Senate, but groups such as the National Council of Churches of Kenya (NCCK) urged the chamber in a letter last month to scrap it.

"The bill normalises underage sex and goes further to open the children between the ages of 10-17 that they should receive contraceptives, safe abortion, and comprehensive sex education which teaches that sex is for pleasure and sexual pleasure is a right," said the letter, which was also sent to the Thomson Reuters Foundation.

"Such behaviour would lead to increase demand for abortion and eventually unstable families in Kenya," it said.

(Reporting by Nita Bhalla @nitabhalla, Editing by Helen Popper. Please credit the Thomson Reuters Foundation, the charitable arm of Thomson Reuters, that covers the lives of people around the world who struggle to live freely or fairly. Visit http://news.trust.org)

Our Standards: The Thomson Reuters Trust Principles.

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Church, anti-abortion groups seen threatening women's health bill - Thomson Reuters Foundation

ICE Is the New Face of America’s Legacy of Forced Sterilization – The New Republic

Earlier this week, multiple human rights organizations filed a complaint on behalf of women detained at an Immigration and Customs Enforcement facility in Georgia. Based on accounts from detainees and corroborated by a nurse who worked at the facility, the Irwin County Detention Center, the complaint alleges multiple examples of substandard medical care, particularly around coronavirus prevention and treatment. But what has drawn the most public outcry is allegations of what has been described as mass hysterectomies or sterilizations.

When I met all these women who had had surgeries, I thought this was like an experimental concentration camp. It was like theyre experimenting with our bodies, one detained immigrant told Project South, one of the groups who filed the complaint. She said she knew of five other women detained with her at ICDC who said they had undergone hysterectomies between October and December 2019. Ive had several inmates tell me that theyve been to see the doctor and theyve had hysterectomies and they dont know why they went or why theyre going, said Dawn Wooten, the nurse who worked at ICDC and has now come forward as a whistleblower, as quoted in the complaint. Weve questioned among ourselves like goodness hes taking everybodys stuff out. Thats his specialty, hes the uterus collector.

Since the complaint was made public, further specifics have been reportedone physician involved, more womens allegationsand others are still emerging. Detained women face risks and complications if they speak to the media, so what we know directly from them is limited. It is not clear how many have had hysterectomies, and if that was part of an explicit policy or widespread pattern at this detention center or possibly others. What we do know is horrific and, as health care providers and experts have noted, part of a troubling history of reproductive coercion, one that remains with us. The immigration detention system is part of this American system of population control.

The ideology of population control for the greater good is deeply embedded in U.S. policy, explained Dorothy Roberts, law and sociology professor at the University of Pennsylvania and author of Killing the Black Body: Race, Reproduction, and the Meaning of Liberty, speaking by phone this week after the ICE story broke. To discourage childbearing by people who are receiving government public assistancethats written into laws in many states. Efforts to expand womens reproductive choices have been entangled, too, with this ideology. The origins of the movement for birth control is both a feminist movement and a eugenicist movement, and thats going on in the 1920s and 30s, and was only discredited after the Nazi exterminations and their regime of eugenics. But in the United States, the eugenics project goes back furtherbuilt on top of the enslavement of African people and the denial of their reproductive autonomy altogether.

Roberts said she sees the same ideology of reproductive control in the present-day policies and practices targeting immigrants, like family separation and now, allegedly, coercive hysterectomies. Both forced sterilization and the forcible taking of children have been weapons the U.S. government has deployed for hundreds of years, she told The New Republic. Both are political weapons that the U.S. government has used against marginalized groups for political reasonsto terrorize them, to punish them, and to marginalize them further.

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ICE Is the New Face of America's Legacy of Forced Sterilization - The New Republic

3CL Protease Inhibitor NLC-001 Added to COVID-19-focused Joint Venture Between Todos Medical and NLC Pharma – BioSpace

NEW YORK, REHOVOT, Israel and SINGAPORE, Sept. 17, 2020 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- Todos Medical Ltd.(OTCQB: TOMDF), anin vitrodiagnostics company focused on developing and distributing comprehensive solutions for COVID-19, and developing blood tests for the early detection of cancer and Alzheimers disease, today announced that NLC Pharma has added the dietary supplement NLC-001 to its joint venture with Todos Medical. NLC-001 is an orally administered proprietary blend of plant extracts that includes a powerful potential 3CL protease inhibitor that could help support and maintain healthy immune function. The 3CL protease plays a vital role in the intracellular replication of coronaviruses, and 3CL protease inhibition is being evaluated as a potential therapeutic target for coronaviruses.

In looking at the landscape for COVID-19, it is becoming clear that despite the large number of alternatives being investigated and used today, some of our best weapons may in fact be natural oral compounds that help to boost immunity or reduce excessive inflammation, said Jorge Leon, Ph.D., Chief Medical and Scientific Officer for Todos Medical. Using 3CL protease inhibitors to help support immune function against coronaviruses is based on sound science. The role of a 3C protease inhibitor could be to slow or stop viral reproduction. This could support and maintain healthy immune function by giving the body time to recognize a coronavirus and mount an immune response to terminate the virus. Pfizer recentlyannouncedthe development of such an inhibitor as a potential pharmaceutical drug for COVID-19. NLC Pharma had worked in parallel with Agouron (later acquired by Pfizer) for many years to identify 3C inhibitors for Human rhinovirus (HRV). We believe the NLC-001 3CL protease inhibitor may ultimately prove to help support and maintain healthy immune function against various strains of coronaviruses, as it is based on a fundamental mechanism that does not change within the coronavirus family.

Under the terms of the agreement, Todos has been granted exclusive worldwide distribution rights for various formulations of NLC-001, excluding Israel, as well as a right of first refusal to develop pharmaceutical drugs based on the NLC technology. Todos is responsible for all commercial activities, including manufacturing, clinical testing, marketing and distribution outside of Israel. NLC will be responsible for the commercialization of NLC-001 in Israel. NLC-001s active ingredient is on the Israel Ministry of Healths authorized dietary supplement import list. The U.S. Food & Drug Administration (FDA) granted a Certificate of Free Sale for NLC-001 to the Joint Ventures U.S.-based contract manufacturer on August 28, 2020. NLC-001 has not received FDA approval as a prophylactic or as a therapeutic intervention for COVID-19. The companies will work together to meet the remaining regulatory requirements to distribute branded versions of NLC-001 as a dietary supplement to help support and maintain healthy immune function in the United States. NLC Pharma has filed multiple patent applications covering the NLC-001 program worldwide.

We started developing 3C protease inhibitors in 1987 as an antiviral against HRV and since early 2000, when SARS surfaced, we have been diligently advancing both our diagnostic and therapeutic understanding of the 3C protease, said Dorit Arad, Ph.D., President & Chief Scientific Officer of NLC Pharma. At a time when others are focused on a vaccine, we are targeting the reproduction mechanism of the coronavirus. Unlike vaccine targets, this mechanism does not change even when the virus mutates. A safe dietary supplement that can help support and maintain healthy immune function by slowing or stopping viral replication, giving the bodys immune system time to mount an appropriate response, is the best route to re-open economies safely and achieve the desired herd immunity. For this strategy to be effective, screening and diagnostic technologies will become more important than ever, and because of this, we believed that Todos was the right partner for this potentially game-changing dietary supplement.

We are extremely excited to add NLC-001 to our joint venture with NLC Pharma due to its strong safety profile, as demonstrated by being granted a Certificate of Free Sale by the FDA, said Gerald Commissiong, President & CEO of Todos Medical. Selected dietary supplements represent some of the most accessible and close-to-market alternatives to improve immune function. NLC is advancing clinical studies at hospitals in Israel to evaluate the efficacy of NLC-001 in the treatment of hospitalized COVID-19 patients. We believe NLC-001 certainly warrants commercialization in the United States as a dietary supplement, without therapeutic claims. We are currently evaluating the best commercialization path for NLC-001.

Key Scientific Publications related to potential of 3C Protease Inhibitors for COVID-19

Science Translational Medicine

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoVinfected mice (https://stm.sciencemag.org/content/12/557/eabc5332 )

Abstract

Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the newly emerged SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). We describe herein the structure-guided optimization of a series of inhibitors of the coronavirus 3C-like protease (3CLpro), an enzyme essential for viral replication. The optimized compounds were effective against several human coronaviruses including MERS-CoV, SARS-CoV, and SARS-CoV-2 in an enzyme assay and in cell-based assays using Huh-7 and Vero E6 cell lines. Two selected compounds showed antiviral effects against SARS-CoV-2 in cultured primary human airway epithelial cells. In a mouse model of MERS-CoV infection, administration of a lead compound 1 day after virus infection increased survival from 0 to 100% and reduced lung viral titers and lung histopathology. These results suggest that this series of compounds has the potential to be developed further as antiviral drugs against human coronaviruses.

International Journal of Microbial Agents

Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286838/ )

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same Betacoronavirus genus, induces severe acute respiratory disease that is a threat to human health. Since the outbreak of infection by SARS-CoV-2 began, which causes coronavirus disease 2019 (COVID-19), the disease has rapidly spread worldwide. Thus, a search for effective drugs able to inhibit SARS-CoV-2 has become a global pursuit. The 3C-like protease (3CLpro), which hydrolyses viral polyproteins to produce functional proteins, is essential for coronavirus replication and is considered an important therapeutic target for diseases caused by coronaviruses, including COVID-19. Many 3CLpro inhibitors have been proposed and some new drug candidates have achieved success in preclinical studies. In this review, we briefly describe recent developments in determining the structure of 3CLpro and its function in coronavirus replication and summarize new insights into 3CLpro inhibitors and their mechanisms of action. The clinical application prospects and limitations of 3CLpro inhibitors for COVID-19 treatment are also discussed.

For information related to Todos Medicals COVID-19 testing capabilities, please visit http://www.todoscovid.com

For testing and PPE inquiries, please email sales@todosmedical.com.

About NLC Pharma

NLC Pharma Ltd., an Israeli company, was founded by Dr. Dorit Arad, a leading physical organic chemist with more than 25 years of experience in the Life Science industry, specifically in research and development of infectious diseases.

NLC is in the process of producing developing and commercializing a COVID-19 rapid detection kit, to prevent further spread of the pandemic. In addition, NLC aims to develop an antiviral solution for prevention and treatment of the disease. Both products the rapid detection kit and the antiviral drug are based on thorough extensive research and development performed on a crucial viral enzyme the 3CLpro, a 3C-like protease that resembles the human Rhinovirus (HRV) 3C protease, which has a central role in the maturation of several coronaviruses, including the 2003 SARS-CoV and the recent SARS-CoV-2. These products can be globally deployed and serve as a platform to inhibit the spread of other viruses and infectious diseases.

About Todos Medical Ltd.

Headquartered in Rehovot, Israel, Todos Medical Ltd. (OTCQB: TOMDF) engineers life-saving diagnostic solutions for the early detection of a variety of cancers. The Company's state-of-the-art and patented Todos Biochemical Infrared Analyses (TBIA) is a proprietary cancer-screening technology using peripheral blood analysis that deploys deep examination into cancer's influence on the immune system, looking for biochemical changes in blood mononuclear cells and plasma. Todos' two internally-developed cancer-screening tests, TMB-1 and TMB-2, have received a CE mark in Europe. Todos recently entered into an exclusive option agreement to acquire U.S.-based medical diagnostics company Provista Diagnostics, Inc. to gain rights to its Alpharetta, Georgia-based CLIA/CAP certified lab and Provista's proprietary commercial-stage Videssa breast cancer blood test. The transaction is expected to close in the third quarter of 2020.

Todos is also developing blood tests for the early detection of neurodegenerative disorders, such as Alzheimer's disease. The Lymphocyte Proliferation Test (LymPro Test) is a diagnostic blood test that determines the ability of peripheral blood lymphocytes (PBLs) and monocytes to withstand an exogenous mitogenic stimulation that induces them to enter the cell cycle. It is believed that certain diseases, most notably Alzheimer's disease, are the result of compromised cellular machinery that leads to aberrant cell cycle re-entry by neurons, which then leads to apoptosis. LymPro is unique in the use of peripheral blood lymphocytes as a surrogate for neuronal cell function, suggesting a common relationship between PBLs and neurons in the brain. In July 2020, Todos completed the acquired Breakthrough Diagnostics, Inc., the owner of the LymPro Test intellectual property, from Amarantus Bioscience Holdings, Inc. (OTC: AMBS).

Additionally, Todos has entered into distribution agreements with companies to distribute certain novel coronavirus (COVID-19) test kits. The agreements cover multiple international suppliers of PCR testing kits and related materials and supplies, as well as antibody testing kits from multiple manufacturers after completing validation of said testing kits and supplies in its partner CLIA/CAP certified laboratory in the United States. Todos has formed strategic partnerships withMeridian Health,Moto-Para Foundationto deploy COVID-19 testing in the United States.

For more information, please visit https://www.todosmedical.com/.

Forward-looking Statements

Certain statements contained in this press release may constitute forward-looking statements. For example, forward-looking statements are used when discussing our expected clinical development programs and clinical trials. These forward-looking statements are based only on current expectations of management, and are subject to significant risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements, including the risks and uncertainties related to the progress, timing, cost, and results of clinical trials and product development programs; difficulties or delays in obtaining regulatory approval or patent protection for product candidates; competition from other biotechnology companies; and our ability to obtain additional funding required to conduct our research, development and commercialization activities. In addition, the following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: changes in technology and market requirements; delays or obstacles in launching our clinical trials; changes in legislation; inability to timely develop and introduce new technologies, products and applications; lack of validation of our technology as we progress further and lack of acceptance of our methods by the scientific community; inability to retain or attract key employees whose knowledge is essential to the development of our products; unforeseen scientific difficulties that may develop with our process; greater cost of final product than anticipated; loss of market share and pressure on pricing resulting from competition; and laboratory results that do not translate to equally good results in real settings, all of which could cause the actual results or performance to differ materially from those contemplated in such forward-looking statements. Except as otherwise required by law, Todos Medical does not undertake any obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. For a more detailed description of the risks and uncertainties affecting Todos Medical, please refer to its reports filed from time to time with the U.S. Securities and Exchange Commission.

Investor Contact:

Kim Sutton Golodetz

LHA Investor Relations

Senior Vice President

(212) 838-3777

kgolodetz@lhai.com

Corporate Contact:

Daniel Hirsch

Todos Medical

+972.52.6420.126

Dan.h@todosmedical.com

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3CL Protease Inhibitor NLC-001 Added to COVID-19-focused Joint Venture Between Todos Medical and NLC Pharma - BioSpace

Forced Sterilization Is Nothing New to Criminalized People in the US – Truthout

The United States has long used citizenship status and perceived criminality as a means to determine whether individuals deserve basic human rights. This weeks egregious allegations of mass hysterectomies at an immigrant jail in Georgia are consistent with the long U.S. tradition of state-sanctioned eugenics, medical abuse and forced sterilizations against those whose humanity the state does not recognize or value.

News reports on Monday revealed that gynecologists in an immigrant jail in Georgia have performed high rates of hysterectomies, often without the full awareness of the immigrant women themselves.

According to a complaint filed by Project South, the revelation came from a whistleblower named Dawn Wooten, a Black woman who was a nurse at Georgias Irwin County Detention Center. In the detailed account, Wooten shares not only the pervasive accounts of medical neglect and oversight, but also the ways that immigrant womens bodies have been infiltrated by the state.

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In the report, Wooten explains that incarcerated people would be sent to the doctor for medical procedures, including hysterectomies, and they dont know why they went or why theyre going. Often, these women were not given informed consent as the medical procedures were not explained in their native language. At times, these women experienced intimidation and yelling from nurses pressuring them to follow through with unwanted or unnecessary procedures. In one account, a migrant woman simply came to the conclusion that something was not right when incarcerated migrants were being coerced into procedures that werent clearly explained or consistently described by medical staff.

These disturbing reports from Georgia are not surprising within the larger context of human rights abuses in the U.S. Since 2016, the conditions facing migrant people interned by the U.S. Immigration and Customs Enforcement (ICE) have been a constant source of unrest and public upheaval. The images often depict dilapidated cells, makeshift bedding, and a lack of basic amenities like clean water and food for people jailed by ICE. While the treatment of migrant people on the border and the disregard for the lives and experiences of incarcerated people in this country has long been an issue, this moment has forced the public to grapple with the disparities in justice and liberty in new and disconcerting ways.

The reported resurgence of forced sterilizations at Georgias Irwin County Detention Center a form of violence rooted in white supremacy, xenophobia, patriarchy and the inherently racist tenets of American citizenship are an unfortunate recurrence in this nations short history. In times of contestation, sexual violence and reproductive injustice frequently become the currency of the state.

Many people are colloquially familiar with the story of the Tuskegee Experiments on Black men which began in 1932. It was officially called Tuskegee Study of Untreated Syphilis in the Negro Male. What many people dont know is that these experiments lasted approximately 40 years even though they were projected for only six months of experimentation. The study originally included roughly 600 Black men mainly from Macon County, Alabama, 201 of whom did not actually have syphilis. The study deceptively enrolled Black men without allowing them informed consent, as researchers told participants that they had bad blood and many were never treated at all.

The United States Public Health Service made the decision not to treat poor Black men for syphilis, but rather to watch them until they died and their bodies examined for ravages of the disease, according to The Washington Post.

The study officially ended in 1972 and has been linked to lower life expectancy among Black men over 45 and a deep distrust between Black communities and Western medicine. The emotional and mental effects of this study remain hidden from popular culture and mainstream news, leaving many Black communities to struggle against these sorts of medical disparities in relative isolation.

Eugenics is often associated with Nazi Germany but, in the early 20th century, the United States adopted these techniques in grand fashion. Our disgusting history with forced sterilizations is linked to a 1927 court decision in Buck v. Bell. The decision gave institutions like prisons and mental facilities the ability to sterilize any person in their custody for any reason deemed necessary to protect the better interests of society. Carrie Buck was determined to be feebleminded so the state took away her ability to reproduce children. This stemmed decades of state institutions using their authority to forcibly sterilize incarcerated people. Its estimated that some 70,000 people were sterilized until the 1970s.

But, Buck v. Bell has never been overturned. As late as 2006 to 2010, California prisons have been found to have enforced the coerced sterilizations on at least 150 incarcerated people, according to PBS. As recently as 2017, a judge in central Tennessee offered shorter jail times to incarcerated people if they consented to sterilization. These procedures are used by prison administrators to disproportionately target and harm Black and Brown women, deeming them unfit for reproduction and marking their wombs as sites of waste and decay.

The United Statess commitment to eugenics, medical abuse and forced sterilizations depicts the complex nature of perceived criminality in this country. By marking certain peoples bodies as inherently evil, anti-patriotic and outside of the community of citizenship, the state casts a veil over the grave human rights infringements and institutional abuses it enacts against nonwhite, non-wealthy, non-male, non-normative people. This is by design, not by happenstance.

In her 1994 essay, Not Just (Any) Body Can Be a Citizen, M. Jacqui Alexander wrote, criminalization functions as a technology of control, and much like other technologies of control becomes an important site for the production and reproduction of state power.

Criminalization is the mechanism by which people are transposed from humans into bodies through the eyes of the state. By criminalizing, ostracizing and excluding Black, Brown, queer, trans, immigrant and disabled people, the state sanctions all manner of macabre violence against those they see as merely bodies, organs, and a collection of pieces and parts.

The state is not invested in the humanity of all people but only in the humanity of a chosen few. Until we recognize and hold that truth to be self-evident, we will be powerless in holding these institutions and systems accountable for the injustices they continue to commit right in front of our faces.

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Forced Sterilization Is Nothing New to Criminalized People in the US - Truthout

Creighton painting professor takes on new role at the medical school teaching medical humanities – KMTV – 3 News Now

OMAHA, Neb. (KMTV) Medical humanities is something taught to medical students so they learn to understand patients more holistically. One Creighton University professor is taking an artistic and personal approach to her lessons.

Rachel Mindrup has been painting her whole life. It was her calling. But after her son was diagnosed with a genetic disorder before he even turned one, her calling changed.

Hes got an optic tumor and hes got about four tumors on his brain now," Mindrup said.

Her son Henry Mindrup has NF, or Neurofibromatosis. It's a genetic disorder that causes tumors to grow all over the body. To help deal with all the complications that come with that, Mindrup did what she knows how to do best.

I didnt really set out to start painting portraits of people with the some genetic disorder, I just didnt know what I was supposed to do," she said.

One in 3,000 people are affected by NF, but Rachel says no one knows about it. So, she began her series of portraits called "The Many Faces of Neurofibromatosis" to raise awareness.

Now, the painting professor is taking on a new role at the medical school to bring together the arts and medicine with medical humanities.

So the med students are going to be drawing and observing and actually asking themselves do they trust their eyes or are they just always going to go with whats on the patient chart," Mindrup asked.

Rachel says NF is different in each person. She wants to teach the medical students at Creighton to look past the patient chart with not only this disorder but all types of cases.

Kind of caring for the whole person and also thinking more holistically. Where does this person come from? What are the background experiences? Are they scared right now? What do they need from me? And it might not always just be an in an out, six minutes, heres a prescription, see you later," she said.

This is the first role of its kind at Creighton's newly formed Department of Medical Humanities at the medical school.

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Creighton painting professor takes on new role at the medical school teaching medical humanities - KMTV - 3 News Now

Medical schools pivot to prepare and protect students for front-line work – The Globe and Mail

Years of medical school, graduate school and clinical hours are meant to make doctors ready for anything. But no number of disaster-scenario trial runs or years of on-the-ground experience could have prepared health care professionals for the early weeks of the COVID-19 pandemic.

Nothing like whats happened with COVID-19 prepared us for what was coming, says Parveen Wasi, associate dean of postgraduate medical education at McMaster University.

Even in Toronto, with its handling of SARS1 in 2003 and H1N1 flu in 2009, the learning curve has been steep.

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The disease and the pattern [of the viruses] are different, but the principles were familiar, and we had some structures in place, explains Glen Bandiera, associate dean of postgraduate medical education at the University of Toronto. The magnitude of this response was bigger and the threat [the pandemic] posed to the system was greater because of the sheer numbers of [patients], the lack of personal protective equipment and the impact on the health work force.

Medical schools were doubly hit: Not only were they responsible for the continuance of studies and keeping student residents safe, they also had to change the way medical education was being delivered, and quickly. Medical students were pulled from all clinical settings in March across Canada and didnt start returning until August, which meant a large number of training hours had to be made up.

And while residents are still in training, theyre also hospital employees and, therefore, essential workers. We had to start from ground zero in terms of how we protected our residents and then how we planned education around the pandemic, Dr. Wasi says.

This meant identifying gaps in the system, such as issues around PPE. For example, health care professionals using N95 respirators are required to be fitted every two years. At some hospitals, many of the residents had never been fitted and there was no documentation to confirm who had. As PPE use is exacting, protocols must be followed to protect patients and health care workers; how its done changes, depending on the level of exposure to infectious agents.

I mask-fitted two years ago, but when I actually had to use one, I wasnt 100 per cent sure how to, Dr. Wasi says. Training for PPE how to don and doff appropriately, how to put on an N95 mask was hit and miss prior to this.

The pandemic has also highlighted the need for more training in infection control for postgraduate students. We just assumed it would also occur in the hospital setting, Dr. Wasi adds. So, lesson learned.

Over all, the response by medical schools to the new world has been overwhelmingly swift and often innovative. While U of Ts medical school includes pandemic planning in its curriculum, a specific COVID-19 curriculum was constructed for third-year students returning to clinical environments in the summer. The new program includes PPE instruction, a mask-fit for N95 and an in-depth study of the virus itself.

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Dr. Patricia Houston, vice-dean of medical education at the University of Toronto.

Thomas Bollmann/The Globe and Mail

Patricia Houston, vice-dean of medical education at U of T, says students learn about ethical concepts, palliative care and virtual delivery of health care. We give them tips about how the hospital [is] different in these pandemic times. We also help them to deal with it personally and talk about being resilient.

Within a week of COVID-19 being declared a pandemic, Dr. Houston says the school had moved lectures, small-group learning sessions and even clinical skills courses online. Our pivoting is all strategic, and [the changes] will form the new normal, which have to be robust enough and responsive enough to future needs.

Since mid-March Roger Wong, vice-dean of education at the faculty of medicine at the University of British Columbia, has been adapting the curriculum, beefing up sections on public health, social determinants of health and disease-specific treatment strategies, as well as developing COVID-19-specific sessions for final-year medical students.

UBC also moved to a blended mode of curriculum delivery, virtual and in-person when possible. It developed a free online learning module for medical and health professional students on how to use PPE appropriately. And over the summer, Dr. Wong and his team created a virtual anatomy lab, offering students three-dimensional scans of specimens to study at their leisure.

Its fair to say that everyone around the world is learning actively as the situation evolves, he says. [The pandemic] has catalyzed a large number of innovations in medical education that would have taken decades to happen otherwise. It would be almost unimaginable.

Alim Pardhan, assistant professor of emergency medicine at McMaster, says flexibility for medical schools, doctors and hospitals is key, for example, changing the focus of the health care system from a single discreet event with lots of patients to a longer-term event that might last a year or two where you have higher volumes, fewer beds available and extra precautions with certain patients.

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All agree that COVID-19 will have an enduring impact on health care. Dr. Houston hopes the experience of the past six months will increase the support for, and understanding and appreciation of, public health.

Were always looking for the next cutting-edge medicine, she says, but we need to understand how we can better take care of not just individuals, but populations and communities. And thats something public health teaches us to do.

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Medical schools pivot to prepare and protect students for front-line work - The Globe and Mail

Open Eyes and Hearts – Harvard Medical School

For 50 years, the Poussaint Prematriculation Summer Program (PPSP) at Dana-Farber Cancer Institute has given incoming Harvard Medical School students from underrepresented groups an opportunity to immerse themselves in the world of science and medicine before starting classes. The format of this years program may have changedbecoming all-virtual because of the coronavirus crisisbut the spirit of learning and professional apprenticeship was fully intact.

At a teleconference forum on July 24, the 12 participants spoke about their experience with the program and what they will take from it as they begin their medical education. The students had spent the previous two weeks learning about cancer care and research from Dana-Farber clinicians and scientists and began their HMS degree programs during the first week of August.

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In her opening remarks, Andrea Reid, director of the HMS Office of Recruitment and Multicultural Affairs (ORMA) and associate dean for students and multicultural affairs at HMS, thanked Dana-Farber faculty and others who led and administered the program. You are the bedrock of the PPSP, she said. As lecturers, workshop leaders and lunchtime speakers, you put the same thoughtfulness and enthusiasm into the virtual experience that were the hallmarks of PPSP in its more traditional format.

The PPSP was created in 1970 by Alvin Poussaint, professor of psychiatry, emeritus, and founding director of ORMA at HMS, to give underrepresented students an opportunity to take science courses the summer before their first year in medical school and gain exposure to laboratory research. By 2016, it had evolved into an oncology-focused program with courses, seminars and virtual clinical experiences led by HMS and Dana-Farber faculty. Now co-sponsored by Dana-Farber and ORMA, the PPSP is supported by the Richard and Natalie Jacoff Breast Oncology Fund in honor of Lorraine Hunt Lieberson.

One of the reasons Dana-Farber became involved in this program is our desire to diversify the workforce in oncology in general and DFCI in particular, taking advantage of the excellence of students entering HMS who will be based in the Longwood area and who can easily become engaged in our research and clinical activities, said Robert Mayer, faculty associate dean for admissions at HMS, faculty vice president for academic affairs at Dana-Farber and an administrator of the PPSP.

In their reflections, students spoke about how the program had changed their perceptions of cancer and broadened their understanding of its impact on patients and families.

We had the privilege of learning about both the pathophysiology of cancer and the real-life experience of a cancer diagnosis and treatment from patients, said Angela Marie Mercurio, who graduated from the University of Nebraska. I found myself questioning what cancer means for people who feel like their entire lives are upended by a single word, a diagnosis. I also found myself thinking about the power that physicians hold in delivering this life-changing information. The responsibility that a physician has to hold a patients history, family, dreams, purpose and experience in balance with the finality of a diagnosis that can change it all.

Arinzechukwu Nwagbata, a native of Nigeria and a graduate of the University of Texas, also found himself thinking about the role of the physician, as well as the molecular intricacies of cancer. Illnesses may affect the patients family as much as the patient, and its left to a physician to be sensitive to the needs and worries of a patients family, he said. In oncology, families often find themselves worrying about the patient, the possibility of the cancers predisposition to other family members and the alarming costs of health care.

Nearly all the participants spoke of their admiration for the patients theyd met, their fortitude in the face of a difficult diagnosis.

Interacting with the patients, listening to their stories and observing how they respond to their diagnosis was priceless, said Trinity Russell, a graduate of Wesleyan University.

Even when their condition was seemingly unfavorable, the patients were filled with admirable levels of hope. Of all the moments I experienced during the past two weeks, perhaps the most memorable one occurred when the mother of a young patient shared an image of beads on a string. Every bead represented a procedure or cancer milestone the child endured. I was shocked by the length of the string, especially since the patient was only a few years old. The image of all the treatments strung in succession is one that I will hold close to my heart, Russell said.

Adapted from a DFCI Online article.

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Open Eyes and Hearts - Harvard Medical School

Ald. George Cardenas lavished with cash, luxury trips by Omni Medical Student Training program for Caribbean – Chicago Sun-Times

A Chicago doctor is suing his business partner, accusing her of looting more than $3.7 million from their business to finance an extravagant lifestyle and to lavish Ald. George Cardenas (12th) with luxurious trips, an expensive watch and a monthly stipend for consulting services.

Cardenas had been hired to drum up business for Omni Medical Student Training, which places students from Caribbean medical schools in residency programs with Chicago hospitals. The alderman wasnt very successful in getting hospitals to sign up, though, according to the suit.

Omnis owners Dr. Vivek Gupta and Theresa Siaw are fighting in court over her use of Omnis money the past five years, including payments to Cardenas, for Siaws mortgage and as much as $370,000 spent on her failed bid to defeat Ald. Robert Maldonado (26th) last year.

Three months after Siaw lost that election, Gupta filed suit in Cook County circuit court, accusing his partner of spending Omnis money without his approval.

Gupta says in the lawsuit that he discovered this after the Internal Revenue Service began auditing the company. He says the unauthorized expenses continued this summer, with Siaw withdrawing $251,442 from an Omni bank account, according to the suit.

Siaw, 33, says she didnt spend money without Guptas approval. In sworn pretrial testimony in a deposition she gave earlier this year, Siaw says Gupta gave her permission to use Omnis money to run for alderman and that he sued her because she ended their sexual relationship.

Gupta and his lawyer William Quinlan wont comment.

City Hall Inspector General Joseph Ferguson questioned Siaw earlier this year as part of an investigation into Cardenas campaign finances. Siaw fought his subpoena in court for nearly a year before agreeing to talk with his staff.

Cardenas, 55, wont talk about the $6,000 in campaign contributions he got from Siaw, their trips to Miami and Los Angeles seeking hospitals to accept the Caribbean medical students or the $5,000 watch he got as a bonus from Omni and then wouldnt return when a hospital decided against working with the company after all.

The alderman whose ward includes Little Village and Brighton Park says he provided consulting services to Theresa Siaw years ago. He referred question to his lawyer Ricardo Meza, a former federal prosecutor and state inspector general, who says, George Cardenas has done nothing wrong.

Siaw says she met Cardenas in 2012 when her boyfriend, Dr. Amer Rustom, ran the San Pablo Medical Center inside a building the alderman and his family owned at 2829 W. Cermak Rd. Siaw, who was pregnant with Rustoms son, signed a five-year lease with a minimum yearly rent of $32,400.

He didnt tell me he was an alderman, Siaw says of Cardenas. When my sons father drowned, thats when I started to get close to Cardenas. I was just mutual friends with Cardenas.

Rustom was boating on Lake Michigan with friends in September 2014 when he drowned, leaving behind four sons he had with three women.

Siaw met Gupta months later, and, in June 2015, they started Omni Medical Training, a program similar to Siaws previous business, International Medical Placement. Omni Medical Training operated out of Weiss Memorial Hospital until August, according to a Weiss spokeswoman who says the lease ended and that the North Side hospital no longer uses Omni to place students.

In her deposition, Siaw says the alderman recommended the company hire his brother Jose Cardenas as Omnis accountant and that Jose Cardenas prepared the 2016 federal tax returns that the IRS later audited.

Between 2016 and 2017, Siaw says she paid Cardenas Consulting $28,900, using Omnis money.

In 2016, Siaw made two contributions, totaling $6,000, to the aldermans campaign. She says she made those political contributions using Omnis money.

Cardenas helped Gupta get a contract with Cook County Care, a Medicaid plan run by the Cook County Health and Hospitals System, according to Siaws deposition. She says the alderman also helped Gupta join the Chicago Housing Authoritys health partners program.

Siaw says Cardenas was paid between $2,200 and $2,500 a month to help Omni try to arrange to place medical students at Mount Sinai Hospital, Rush University Medical Center and St. Anthony Hospital but they struck out.

I always consulted with George Cardenas because he has brought contracts to Omni, Siaw says in the sworn testimony. Hes helped me, you know, get a connection with some hospitals.

Siaw testified that she had agreed to give Cardenas a $5,000 bonus if he could help Omni secure a contract with Rush and that Cardenas asked for a watch from Razny Jewelers on the Gold Coast.

I discussed it with Dr. Gupta, Siaw told attorneys in the civil case. I never had somebody ask me for something like that before.

Siaw testified she bought the watch for Cardenas but that the deal with Rush fell through, and the alderman wouldnt return the watch: He basically told me that hes not giving it back.

Meza denies that.

Cardenas was not paid for services rendered and was owed a substantial amount of money by one or more of the business partners, Meza says. The watch was payment for some but not all past-due services owed.

He says Cardenas was supposed to have been paid $2,000 a month but that, For many months, he was not paid at all.

He says the aldermans work for Omni ended in 2017.

Cardenas accompanied Siaw on two trips, trying to land deals for Omni to place Caribbean medical school students at hospitals in Miami and Los Angeles, records show. In December 2016, they stayed in a two-bedroom suite at the luxury Fontainebleau Miami Beach hotel, costing the company more than $19,000, according to records. Siaw testified that no other rooms were available. She also spent $17,199 at a Miami nightclub.

In June 2017, they stayed at the Four Seasons Hotel in Beverly Hills, according to the suit, which doesnt detail the cost.

Siaw also used Omnis checking account to buy two vehicles for $88,854, including a BMW that Cardenas was allowed to drive. Siaw says Cardenas drove the car for just 12 miles but refused to return it to her.

I thought he was avoiding me when I asked him for the car, Siaw told the Chicago Sun-Times. Our relationship ended over a car.

We were really good friends for a long time. It soured because he wasnt delivering what I was paying for.

On Aug. 25, Siaw was removed as Omnis manager by an arbitrator, former federal prosecutor James S. Montana Jr., who is presiding over the case under the terms of Omnis operating agreement.

The record in this matter is brimming with evidence of Ms. Siaws unauthorized, personal use of Omni Student funds, including extensive admissions by Ms. Siaw during hearing testimony, Montana wrote. Ms. Siaw has demonstrated she is essentially incapable of not using Omni Students funds for her personal use.

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Ald. George Cardenas lavished with cash, luxury trips by Omni Medical Student Training program for Caribbean - Chicago Sun-Times

OUWB Anesthesiology Interest Group wins top honor in US – News at OU

Oakland University William Beaumont School of Medicines Anesthesiology Interest Group was recently named the American Society of Anesthesiologists Outstanding Anesthesia Interest Group for 2019-20.

It was the fourth consecutive year that OUWB students in the Anesthesiology Interest Group (AIG) were awarded a top honor from the American Society of Anesthesiologists (ASA). (The announcement came just a couple of weeks after OUWBs Pediatric Interest Group was named Pediatric Interest Group of the Year by the American Academy of Pediatrics.)

According to the society, awards are presented annually to those AIGs that show an exceptional level of participation, enthusiasm, program quality, professionalism, and involvement in their university, community, and at (ASAs) annual meeting.

The OUWB AIG currently at about 240 members edged out similar organizations from medical schools across the U.S., including last years winner from University of California San Francisco. (OUWB was named ASAs Most Innovative AIG in 2019.)

Through this award, the American Society of Anesthesiologists recognizes OUWB as an outstanding school for what we do in our group and the opportunities that we provide for students, said Alan Nguyen, the OUWB student who served as president for 2019-20. This lets program directors and other students know that (OUWB) is a contender.

The fact that weve won an award four years in a row is really saying something about our students and the dedication that they put into events, he added.

OUWBs AIG, launched in 2013, is designed to increase awareness of the spectrum of clinical practice in anesthesiology as well as encourage medical students to explore career opportunities within the field of anesthesiology.

The group aims to go beyond whats available through the OUWB curricular experience by providing opportunities for mentorship, education, and hands-on experience with anesthesiology faculty and residents.

Anesthesiology is one of those specialties where you might not get that much exposure in your first and second years (of medical school), said Paul Patel, current president of OUWBs AIG. The role we play in offering those anesthesiology-related connections and activities is crucial in providing early exposure to a field they otherwise might not get until their fourth year.

Patel said the group aims to hold an event once a month. Among other events held by OUWBs AIG in the last year were:

We put a lot of effort into making events that participating students, residents, and doctors will enjoy, said Nguyen. To get the Outstanding AIG Award offers proof positive that our hard work really does pay off.

Prior to last year, ASA annually awarded three schools an Outstanding AIG Award.

In 2018, OUWB shared the honor with the University of Miami Miller School of Medicine and the University of Oakland College of Medicine.

In 2017, OUWBs AIG was named outstanding alongside the University of Oklahoma College of Medicine and Vanderbilt University College of Medicine.

Nguyen said ASA changed the program starting in 2019. Changes included having only one school named Outstanding along with categories for Best New AIG and Most Innovative AIG.

Stacie Griebahn, president, ASA Medical Student Component, ASA, congratulated OUWBs AIG on being one of the top AIGs in an email announcement.

Your AIG deserves recognition as a model AIG that exemplifies the mission of the ASA Medical Student Component to encourage medical student participation in anesthesiology, provide resources for medical students pursuing careers in anesthesiology and providing leadership, research and education in the field of anesthesiology within your school, she said.

For more information, contact Andrew Dietderich, marketing writer, OUWB, atadietderich@oakland.edu.

Follow OUWB onFacebook,Twitter, andInstagram.

NOTICE: Except where otherwise noted, all articles are published under aCreative Commons Attribution 3.0 license. You are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute Oakland University William Beaumont School of Medicine as the original creator and include a link to this article.

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OUWB Anesthesiology Interest Group wins top honor in US - News at OU

How medical students are innovating during COVID-19 – American Medical Association

The pandemic has been an all-hands-on-deck situation for health care. That has meant channeling the brainpower and energy of those who are just starting their careers in medicine: medical students.

Medical students have contributed in the clinical realm, through volunteer work and through embracing challenges in the digital health realm. That has been evident in the work done by Sling Health, an innovation incubator led by medical students and engineering students. The incubator aims to bridge the divide between clinicians and clinical problems.

A recent episode of the AMA COVID-19 Update highlights the way in which student innovation has driven solutions during the pandemic.

For students interested in contributing to innovation during the pandemicand with most internship and development opportunities limitedSling Health offered a digital boot camp. Vithika Nag, a graduate student at Duke's Pratt School of Engineering, was among the attendees.

It was very fast paced, but I think the pressure kept us all on a really good timeline, kept us really productive, so it was just a very rewarding experience, she said. At the end of every week, we had some design reviews as well that kept us on a really nice milestone, and just checking all the things off our list.

Here's how medical student entrepreneurs can find out whether their idea has investor appeal.

Avik Som, MD, is co-founder of CareSignal Health. Both he and his company are Sling Health alumni. The pandemic forced CareSignala digital health company that focuses on deviceless remote patient monitoringto adapt on the fly.

When COVID really struck the United States, we rapidly saw that there was an immediate need among clinicians and hospital systems to get information out there for patients that are potentially experiencing some variation of symptoms, Dr. Som said. We generated, effectively, a text messaging support line, something we call the COVID Suite, and that we ended up giving for free to anyone.

Some medical students may be hesitant to get involved in innovation during their undergraduate medical training. Dr. Som advises students not to let their place in the pecking order work as a deterrent.

As a student, it can sometimes be very intimidating to go into clinic and make the claim, or think, that you can make it better, he said. The game is: Be proactive and don't ever be intimidated by titles. Don't be intimidated by all of the venture capital firms versus the chief medical officers. I found out as a student that just asking questions and bringing itpeople are so excited for the initiative and everybody wants to make it better for the patients.

The AMA has curateda selection of resourcesto assist residents, medical students and faculty during the COVID-19 pandemic to help manage the shifting timelines, cancellations and adjustments to testing, rotations and other events at this time.

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How medical students are innovating during COVID-19 - American Medical Association

"Welcome to Medicine" in-Training, the online peer-reviewed publication for medical students – Pager Publications, Inc.

You dont deserve abuse because youre a medical student.

You dont have to tough it out because youre a medical student.

You dont have to sit in silence and painfully nod along with an attendings racist, misogynistic lectures because youre their medical student. You dont need to pick the skin off your cuticles to stop yourself from replying. You dont need to learn how to hide your grimaces behind your mask because you know youll have to listen to them attack your identity for the next several weeks.

My first interaction with my new attending immediately set off alarm bells in my head: when I introduced myself, he commented on what a difficult name I had and asked twice if he could call me Abby. Throughout the day, he would go on to flippantly joke about mental illness, insist COVID-19 was a liberal political ploy, scoff openly at the message of the Black Lives Matter movement and call every female in the office (including patients as well as myself) inappropriate pet names like baby girl and little lady.

As he casually spouted countless racist or sexist views, I held my tongue and hid my discomfort. He was a white male attending in a suburban clinic and worked exclusively with other white male attendings; it didnt appear he had ever been challenged about his views or his behavior. As a woman of color and a student, I certainly wasnt going to speak up myself. This rotation was 1:1 with the attending and without other medical students, interns or residents to validate my concern, I convinced myself I would just have to make it through the next two months.

From just one day in the clinic, I had compiled a list of 13 bullet points that outlined the most flagrantly inappropriate comments and actions from my attending. But I still didnt trust my experience was I overreacting? Was I being too sensitive? Was I going to ruin this attendings life by voicing my concerns? As just a med student, did I even deserve the right to feel uncomfortable?

When I tentatively mentioned to colleagues and mentors the litany of offensive, problematic statements my attending physician had said during the first two days of my rotation, a common response was, welcome to medicine. That struck a nerve. I didnt want to accept that statement as fact, I didnt want to accept this environment as inevitable, and I didnt feel that we, as the next generation of physicians, should have to. More than my own discomfort, it was the frustrating complacency of that welcome to medicine statement that finally convinced me to reach out to my school about the attending.

I wasnt alone in my hesitancy to bring my concerns to my administration. The 2019 graduation questionnaire by the American Association of Medical Colleges (AAMC) noted that though 40.1% of graduating medical students experienced mistreatment during their time in medical school, only 23.2% of those students reported their experience. Students cited fear of retaliation, doubt that an event was important enough to report and the belief that nothing would be done about the situation as reasons for not reporting.

These were all thoughts that ran through my head; at the bottom of the hierarchy of medical education, we dont trust ourselves enough to believe that what feels wrong might actually be wrong. Most insidiously, a 2018 study found that one of the leading reasons medical students dont report mistreatment during their clinical years is the perception that mistreatment is a normal part of medical education, a rite of passage if you will Welcome to medicine.

When I came forward, I realized I was lucky because I had the most supportive medical school administration I could have hoped for. When I tentatively asked, Is this really that bad? they replied with a resounding YES! making it clear that they were on my side. They took me seriously and removed me from that rotation the minute they heard my concerns. I felt like my safety was their highest priority and Im grateful for that.

While my medical school acted swiftly in my defense, I later learned that other medical professionals were less supportive. After I left my rotation, I heard from students working in the same office that the other attending physicians were whispering about that poor medical student who did the right thing by leaving the clinic. Those physicians discussed amongst themselves how that attending had been becoming increasingly problematic, how his conspiracy theories were getting increasingly incredulous and he was becoming increasingly irreverent towards patients and students. They had known before my name had ever even shown up in the office inbox that this attending was a questionable teacher and provider, but never brought their concerns to the attending himself or the schools who subjected their students to him.

I struggled with pangs of betrayal and loneliness: these physicians had nodded to me in public and had gossiped about that poor medical student in private. While I was fielding microaggressions one-on-one across a desk, berating myself to get a grip, fighting against my own instincts, they had known all along that I was going to struggle and left me to flounder anyways. Those white male physicians, who held the most power in that clinic and would face few consequences by speaking up about a sexist and racist colleague, did nothing.

It genuinely baffled me that they could have these discussions about how inappropriate this attending was and still smile at me walking beside him every morning. I cant help but wonder- perhaps they were so complacent because they didnt see this as an anomaly in medicine. Perhaps they thought it was something students needed to get used to. Perhaps they too thought, Welcome to medicine.

I didnt learn much medicine the first week of my rotation, but I learned something else: I dont want to subscribe to the culture of medicine that makes students believe they have to tough it out. Medicine isnt an old boys club anymore. If we cant expect attendings to speak up on our behalf, then we will have to advocate for ourselves. I dont mean to say that there arent thoughtful, supportive attendings that continue to fight for us there are, and Ive had the privilege of working with many of them.

This experience has shown me, however disappointing the thought may be, that I cant necessarily count on that. But the old guard is not the future of medicine we are. Even as medical students, when we see things that we believe are wrong whether that is sexist and racist comments from attendings, overly harsh treatment of trainees or impolite comments about patients we have both the opportunity and the responsibility to act on them by bringing them up to the administration that oversees medical education. And when we eventually find ourselves in those positions of power as senior residents, attendings or medical school faculty, we must remember what it felt like to be at the bottom of the hierarchy and speak up for those below us. We can work towards a better system than, Welcome to medicine.

Image Credit: Best Shoes for Nurses(CC BY 2.0)bygm.esthermax

Contributing Writer

Saint Louis University School of Medicine

Apshara Ravichandran is a third-year medical student at Saint Louis University School of Medicine in St. Louis, MO. In 2018, she graduated from Williams College with a Bachelor of Arts in anthropology and chemistry. She enjoys reading, running, and going to the local dog park in her free time. After graduating medical school, Apshara would like to pursue a career in a pediatric specialty or child psychiatry.

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"Welcome to Medicine" in-Training, the online peer-reviewed publication for medical students - Pager Publications, Inc.

Can you have both COVID-19 and the flu at the same time? – NJ.com

As flu season approaches some people are asking if it is possible to contract COVID-19 and the flu at the same time.

Unfortunately, yes, you can have both viruses, says Dr. Carl S. Goldstein, Clinical Professor of Medicine at Rutgers-Robert Wood Johnson Medical School.

These are different viruses and because they are structurally different, there is no cross-immunity, Goldstein says.

And if you have both? The risk of respiratory failure requiring a ventilator or cardiopulmonary death is much greater, he says.

The concern is that both of these diseases converge on respiratory failure, Goldstein explains. So COVID independently can lead to ventilator-dependent respiratory failure, as can influenza, and influenza notoriously can set the stage for a bacterial pneumonia occurring on top of influenza. So the risk is that if you are infected with both COVID and influenza, they will both exact harm independently and, likely, synergistically.

Goldstein says those who are already at risk for poor outcomes from COVID are exactly the same people who are at risk for poor outcomes when it comes to the flu.

"That population over 65, underlying cardiac or pulmonary disease, chronic kidney disease, diabetes, HIV, AIDS, cancer or cancer chemotherapy, organ transplant recipient that whole list of people who are at-risk people,' now become at really high risk people, he says, but adds that the the strategies which protect against COVID (masks, hand hygiene and physical distance) are "exactly the same strategies that protect against influenza, making these protective behaviors even more important.

How to tell whether you have COVID-19, the flu or both is a call best made by your physician, Goldstein says, adding that early intervention is critical for high-risk patients.

Clinically they both may present with fever, cough, muscle aches and pains. You cannot rely on symptoms to discriminate between these two diseases or between more common viral infections, he says. And if youre a person at risk and you develop respiratory symptoms any of them: fever, chills, cough, congestion shortness of breath, any of them if those symptoms are anything other than really ordinary, that probably deserves medical assessment because both influenza and COVID can get really ugly, fairly quickly.

And if its just the flu, an early diagnosis can often lead to effective therapy with Tamiflu or other antiviral agents, which, in some cases, could be lifesaving, Goldstein says.

Tell us your coronavirus stories, whether its a news tip, a topic you want us to cover, or a personal story you want to share.

Our journalism needs your support. Please subscribe today to NJ.com.

Jessica Remo may be reached at jremo@njadvancemedia.com.

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Can you have both COVID-19 and the flu at the same time? - NJ.com

$25 million donated to the TCU and UNTHSC School of Medicine – TCU 360

The TCU and UNTHSC School of Medicine received a $25 million donation, contributing to the Lead On campaign.

Chancellor Victor Boschini announced the donation from Anne Marion, who died in February, and the Burnett Foundation on Tuesday in an email to students and faculty.

Instituted as The Anne W. Marion Endowment, the donation will be used to help the school become a top provider of medical education, equipping its students with the skills they need to handle complex health care issues, including those involved with serving patients during the COVID-19 pandemic.

The endowment will enhance the School of Medicines communication-based curriculum designed to cultivate empathetic scholars.

Marions Fort Worth family has been a contributor to TCU for over a century, and individually, she was known as a philanthropic leader and a supporter of the universitys advancement.

I am inspired by the vision of the School of Medicine to transform medical education, Marion said before she died. This school is bringing considerable advances and innovations that are reshaping curriculum and preparing its graduates to better serve the community. I am pleased to make this gift.

The Burnett Foundation has been a longtime benefactor to the Fort Worth community, enriching the citys arts, humanities, education, and health and human services.

This contribution bring the Lead On campaigns total funds raised to $671 million, putting it closer to the goal of $1 billion announced last October.

Read more: Lead On campaign to raise $1 billion

The campaign was initiated to strengthen the universitys endowment and its support of scholarships and academic programs, as well as to increase the diversity and inclusiveness of the student population.

With a goal of $1 billion, Lead On is the most ambitious campaign in the schools history.

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$25 million donated to the TCU and UNTHSC School of Medicine - TCU 360

Westerhouse honored with AAMC Distinguished Service Award – Washington University School of Medicine in St. Louis

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Head of Medical Public Affairs recognized by Association of American Medical Colleges Group on Institutional Advancement

Westerhouse

Joni Westerhouse, associate vice chancellor and associate dean in the Office of Medical Public Affairs at Washington University School of Medicine in St. Louis, has received the 2020 Distinguished Service Award from the Group on Institutional Advancement (GIA) of the Association of American Medical Colleges (AAMC).

The honor presented to Westerhouse on Sept. 17 recognizes her for significant and longstanding contributions to the group, the AAMC and her profession.The GIA is a national professional-development group devoted to the role of institutional advancement in academic medicine.

Westerhouse has overseen the School of Medicines public relations, communications and marketing efforts as associate vice chancellor and associate dean since 2014. She joined the office in 1987 as medical editor of the Record and as a media relations specialist. Over the years, she has taken on myriad roles as a spokesperson, writer, editor, and director and executive director of medical communications before being named an assistant vice chancellor in 2011. She also has had leadership roles in events on the Danforth Campus, including as a member of several presidential and vice presidential debate planning committees.

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Westerhouse honored with AAMC Distinguished Service Award - Washington University School of Medicine in St. Louis

Seeing COVID-19 through a cloud of cigarette smoke The Cancer Letter – The Cancer Letter

publication date: Sep. 18, 2020

Alan Blum, MD

Professor and Endowed Chair in Family Medicine,

Director, The Center for the Study of Tobacco and Society,

University of Alabama School of Medicine, Tuscaloosa

Eric Solberg, MS

Vice president, academic & research affairs,

University of Texas Health Science Center at Houston;

Faculty associate, McGovern Center for Humanities and Ethics,

McGovern School of Medicine, Houston

This story is part of The Cancer Letters ongoing coverage of COVID-19s impact on oncology. A full list of our coverage is availablehere.

The unprecedented COVID-19 pandemic makes it possible to compare and contrast the public health and political responses to previous health crises.

The most obvious comparison is to the influenza epidemic of 1918-19, which took the lives of 675,000 Americans in less than two years.

Yet a comparison with cigarette smoking, which has killed untold millions of Americans in the 20th century and continues to take the lives of 500,000 a year, is arguably more illuminating. At first glance, comparing COVID-19 to cigarettes seems illogical. Yes, people who take up smoking do so willingly, although most do so before they reach adulthood. And yes, those who contract COVID-19 do not willingly seek out the virus.

Disease and death from smoking take years, even decades to occur. Deaths from COVID-19 can occur within days or weeks, albeit in less than 2.9% of victims, most of whom have comorbid conditions such as hypertension, obesity, and emphysema.

As we assess the 50-year War on Cancer that was declared when President Richard M. Nixon signed the National Cancer Act of 1971, some parallels and lessons from the past that can be gleaned from anti-smoking campaigns and applied to the efforts against COVID-19.

As defiant and skeptical as President Trump may be of the preventive behavioral measures that all health agencies agree are the first step to contain the spread of the virus, his magical-thinking approach mirrors the playbook of previous presidents to ending the cigarette pandemic, even decades after it was recognized as the nations leading avoidable cause of death and disease.

Should anyone really be surprised that when it comes to public health and health care, money and politics take precedence over science?

In early April, no sooner had Anthony Fauci, of the White House COVID-19 Task Force, come to the conclusion that all Americans, not just front-line health workers and patients, needed to wear face masks, practice social distancing, and wash their hands to prevent the spread of COVID-19, President Trump began subverting this message by retweeting Faucis original assertion in March that mask-wearing by the general public was not yet necessary.

By mid-summer, Trump had rejected the recommendations by the Centers for Disease Control and Prevention on protecting meat processing plant workers, teachers, other school personnel, and children from COVID-19. Trump not only muted, muzzled, and marginalized the CDC, he had also become its de facto spokesperson.

Even as he has publicly played down the ease of spread and the adverse health consequences of COVID-19, last week we listened to the recording of his February interview by reporter Bob Woodward, in which Trump acknowledged the ferocity of the new virus.

This called to mind the response by another president to the efforts by the top health official in his administration to launch the federal governments first anti-smoking campaign. In January 1978, U.S. Secretary of Health Education and Welfare Joseph A. Califano, Jr., announced that HEW would place the weight of its scientific authority behind programs to inform the publicespecially the youngabout why they should not smoke and how they can quit if they wish. As the chief health officer of government, I have the duty to see that we do just that.

Within weeks, Califanos efforts were being undermined by President Jimmy Carter, who traveled to North Carolina to assure tobacco famers that the government would make cigarette smoking even safer than it is today. As Califanos campaign continued to gain momentum, and after HEW published the most comprehensive indictment yet of cigarette smoking in its 1979 Surgeon Generals Report, Carter fired Califano. There was little doubt that the main reason was his fervent anti-smoking stance.

The present-day Republican-led opposition to state and local ordinances mandating the wearing of face masks in public places is akin to the vocal opposition in 1964 to federal legislation to require an understated warning on the side of cigarette packs (Caution: Cigarette Smoking May Be Hazardous to Your Health).

The staunchest opponents of the warning were not just the cigarette manufacturers and tobacco state congressmen, but also the American Medical Association, which claimed that the public was already well informed about the dangers of smoking.

In those days, Republican Sen. Jesse Helms were beating back anti-smoking bills introduced by Democratic Sens. Ted Kennedy and Dick Durbin and Reps. Henry Waxman and Ron Wyden. Today, we can take in the spectacle of Republican Sen. Rand Paul (a physician) and Republican House Members Matt Goetz, Luis Gohmert, and Mark Meadows deriding the recommendation to wear face masks.

All four contracted COVID-19, with Gohmert blaming his infection on having to wear a mask.

At his nationally televised town meeting on Sept. 15, in which he claimed that herd mentality could make the virus disappear, Trump also claimed that the repeated putting on and taking off a mask could increase the chances of becoming infected with COVID-19.

The other two physicians in the Senate, Republicans John Barrasso and Bill Cassidy, have stood behind Trump every step of the pandemic. In May, Barrasso, an orthopedic surgeon until he was appointed to the Senate in 2007, cited his medical background to support Trumps call to end COVID-19 containment shutdowns and echoed Trumps comment that we cannot allow the cure to be worse than the disease.

Granted, oversimplifying the comparison between the response to COVID-19 and the fight against smoking risks reducing it to a body count competition. Yet, that is just what Stanford historian Robert Proctor did in a book review in the July 7 issue of JAMA:

It all seems so February. Cigarettes remain the leading preventable cause of death, but that morbid fact is easily lost in more pressing pandemics. It is worth keeping in mind that even if the novel coronavirus 2019 (COVID-19) ends up killing 200,000 people in the U.S., that number will not be even half the annual toll from cigarettes, which still kill half a million Americans every year.

Such a comment is as simplistic and cold-hearted as any of Trumps unempathetic pronouncements downplaying the catastrophic impact of COVID-19. One hears echoes of the claim that the virus will just disappear, but smoking will remain.

Sadly, this is the same narrative that all too many individuals who work in the field of tobacco control have used for other emerging health crises such as the rapid rise in obesity, namely that smoking is always the bigger killer.

They seem to see other health issues as a threat to their turf. Proctor calls the assertion that his smoking dog is bigger than your COVID dog an enduring constancy and insists that scholars need to pay more attention to cigarettes, even in these distressing days of plague.

Any focus on disease that ignores the cigarette or the cigarette industry is like pretending to have an interest in malaria while paying no attention to mosquitoes or swamps. Nicotine addiction is likely to outlive coronavirus, shackling millions in chains that lead to suffering and death. The havoc wreaked on human health is worse than any virus.

Nathan Schachtman, an attorney and lecturer at Columbia Law School who has written on tobacco litigation, is appalled by Proctors claim. This type of comparison between COVID-19 and smoking is inapposite, he says. COVID puts me at risk from even a brief encounter with an infected person. I have no control as an individual over the risk of this infectious disease; it absolutely requires coordinated action by government. We can all agree that both smoking and COVID are public health problems, while refraining from making inane comparisons. The thing about COVID-19 is that a pandemic ensures that there will be innocent victimspeople who did not assume the risk, but had the risk of death and disability foisted upon them by fellow citizens.

Two hundred thousand deathsin addition to hundreds of thousands of potential long-haulers suffering from crushing fatigue, lung and heart damage, and other problemscaused by a single pathogen in just six months extrapolates to 300,000 deaths this year, plus a lingering morbidity comparable to that caused by cigarette smoking. And there is no cure in sight, but rather false promises by the president of a breakthrough vaccine just around the corner before Election Day.

Instead of trying to make the case that smoking is worse than COVID-19, we should instead be applying the lessons weve learned from anti-smoking efforts to reduce the toll of COVID-19, argues Michael Siegel, professor of community health sciences at Boston University School of Public Health. Most obviously, the chronic conditions of emphysema and cardiovascular disease that help COVID take hold are frequently due to smoking. The successes and failures of the past five decades of anti-smoking actions are playing out now in the daily COVID-19 death tallies.

Writing in Financial Times on Aug. 4, Sir Richard Feachem, who served as under-secretary-general of the United Nations and founding executive director of the Global Fund to Fight AIDS, Tuberculosis, and Malaria, warns that counting on a COVID-19 vaccine to come to our rescue soon is not only unlikely but is a dangerous assumption on which to plan the overall response to the pandemic.

Politicians and vaccine developers have incentives to reinforce this assumption, he notes, in spite of the long odds against a vaccine with high efficacy, a protracted duration of protection, a convenient dosing schedule, and the ability to administer billions of doses.

Is this not reminiscent of the never-ending quest for the Holy Grail of the safe cigarette? Can anyone doubt that the biggest failure in the history of the National Cancer Institute is not to have dispelled the myth that filtered cigarettes can prevent lung cancer?

The tobacco industrys view, as reflected in the Tobacco Observer, a publication of the Tobacco Institute, April 1982.

Following the release of the 1964 Surgeon Generals Report, there was a dramatic increase in advertising claims by the tobacco companies implying that filtered cigarettes were safer than non-filtered ones.

This campaign extended to Hollywood, where TV and movie heroes and heroines smoked filtered brands while the crooks and tramps smoked non-filters. Alas, the history of the filter is at the heart of why the reduction in smoking has been so slow.

Beginning in the early-1950s, when the devastating reports of the impact of smoking on health were making front-page news and beginning to drive down cigarette sales, the tobacco industry took the upper hand by proclaiming in full-page newspaper advertisements across the U.S. that it would fund research to identify and remove any harmful ingredients from cigarette smoke.

By the late 1960s and throughout the 1970s, the National Cancer Institutes research efforts on smoking were almost entirely directed toward finding a safer cigarette. This dead-end research didnt get the ax until 1980, when Vincent DeVita became director of NCI and began shifting the focus of smoking research to getting heavy smokers to quit.

Even then, a far more heavily funded NCI research project in the 1980s was chemoprevention, which aimed to reduce lung cancer in smokers with large doses of vitamin A. The highly promoted study was halted when it was found that this caused an increase in lung cancer.

The unequivocal conclusion of the landmark 1964 U.S. Surgeon Generals report on smoking and health that cigarettes cause lung cancer and other diseases was to have ended a debate that had raged for decades.

Instead, the tobacco industry made a preemptive strike by funneling a total of $18 million over 14 years to the American Medical Associationthe only major health organization to withhold its endorsement of the reportin a research program to identify and remove any possible harmful components of cigarette smoke.

Why did the AMA choose not to campaign against smoking, but rather to conduct the same kind of research that the report had already found sufficient for its indictment of smoking?

It did so in order to remain in the good graces of tobacco state senators, whom it counted on to help prevent the creation of Medicare by Congress. This, in turn, leads to another villain that has gone unnoticed: the insurance industry, which never lifted a finger to fight smoking, even long after a small Massachusetts insurer, State Mutual Life Assurance Company, offered the first non-smoker discount after the SG report came out in 1964.

Because the anti-smoking narrative has been revised as a great victory instead of an abject failure, the rogues gallery is endless. One of the genuine leaders was the fearless Sen. Maureen Neuberger, who castigated not just the tobacco companies but also the see-no-evil, hear-no-evil, speak-no-evil AMA in her 1964 book Smoke Screen: Tobacco and the Public Welfare.

The AMA/tobacco industry collaboration distributed research funds to dozens of universities to keep scientists in their laboratories and not out testifying to the need to end smoking now. Columbia University, although not a participant as an institution with the AMA program, went so far as to market a patented super-filter that it claimed would remove the cancer-causing tar and prevent lung cancer. It didnt.

The filter con endures to the present day. Ninety-nine percent of cigarettes sold are filtered brands, in spite of the fact that filters likely increase the risk of death and disease from smoking by virtue of the smoker needing to inhale more deeplyand by fostering complacency about the dangers of smoking.

Essentially the same kind of players that fought efforts to pass clean indoor air legislation or bills to ban or restrict cigarette advertising and promotion are at it again with COVID-19. The cigarette companies filter and low-tar hucksterism is not unlike the touting by Trump of oleander, hydroxychloroquine, zinc, bleach, Lysol, and UV light for the prevention of COVID infections.

Meanwhile, Trumps COVID-19 advisers include individuals untrained in infectious disease, notably retired Stanford radiologist Scott Atlas. In a scathing op-ed in the Los Angeles Times on Sept. 10 by Stanford epidemiologists Steven Goodman and Melissa Bondy, co-signed by all of their epidemiology colleagues at the university, the authors castigate Atlas for recommending less COVID-19 testing and less mask-wearing in indoor public spaces, as well as for downplaying the nonfatal health risks of the virus and its transmissibility by children.

The Washington Post and The New York Times were criticized by an editorialist at The Wall Street Journal for questioning Atlas fitness and credentials, even though Atlas got the job after espousing his unconventional views on Fox News. Both the Journal and Fox News are controlled by the pro-Trump Murdoch family, whose patriarch Rupert Murdoch served on the board of Philip Morris from 1989 to 1998; Philip Morris executives in turn have served on the board of Murdochs News Corp.

To think that in 1854, fully 40 years before Robert Koch discovered the bacterium that causes cholera, a lone London obstetrician named John Snow identified the source of a cholera outbreak with pencil, paper, and shoe leather.

By interviewing surviving family members of many of the more than 500 victims, he realized that the fatalities were clustered around a single water pump in Broad Street, from which most of the victims had obtained their household supply.

Countless lives were saved when the pump was ordered shut, over the objections of the water companies, which blamed the cholera epidemic on bad air, or miasma. Religious zealots blamed divine intervention.

Ironically, it was a minister, Rev. Henry Whitehead, who at first contended that the outbreak was not caused by tainted water but by Gods will, who surprised himself to discover that the cause was a soiled diaper emptied into a leaky cesspool near the pump.

More than half a century after the causes of the epidemic of lung cancer and emphysema became known through epidemiologic studies, the tobacco industry, like the water companies of Snows London, insisted that their product was not to blame. They were backed up by administration after administration as the cigaretteand its tax revenuesbecame a mainstay of the economy.

Arguably the best single summary of government policy on smoking came from the United Kingdoms Royal College of Physicians in the 1971 sequel Smoking and Health Now to its pioneering report on smoking and health in 1962: Castigating the government for spending little to educate the public about the dangers of smokinga tenth of the amount spent on traffic safety.

The report dryly observes, It seems that Ministers, while accepting the evidence that cigarette smoking is dangerous to health, are guided in their actions by the view that the risks are regrettable but inevitable consequences of a habit which they believe to be an essential source of revenue.

The economy-over-lives approach to COVID-19 by the current president is reminiscent of other administrations approach to curbing smoking.

College football, get out there and play football, Trump said on Aug. 11, when the only major universities left whose officials had given the season a green lightin the Atlantic Coast and Southeastern conferencesare located in the very region with the least adherence to personal COVID-19 health precautions and a steady rise in the number of cases.

By his masks-be-damned rallies and his tweets to Liberate Michigan! and other battleground states with Democratic governors from the inconvenience of wearing a mask and washing hands, Trump has become a 21st century Typhoid Mary, a super-spreader of COVID-19 through his crowded campaign rallies.

By stoking the embers of anti-scientific thinking for years in regard to the safest and most effective vaccines, by mocking the wearing of masks and social distancing, and by claiming that there is a COVID-19 vaccine just around the corner, Trump has undermined confidence in the safety and efficacy of any such rushed-out vaccine by those who would normally support vaccination.

In addition, HHS and FDA have been corrupted by political pressure to approve hydroxychloroquine and convalescent plasma as treatments for COVID-19 in spite of the absence of safety data. Fauci has been told to refrain from stating that children can transmit COVID-19. And CDC has been forced to walk back recommendations on school reopening and contact tracing, and its venerable publication, MMWR has been censored by the administration.

On June 23, Financial Times published the marvelously understated headline, Resistance is low at U.S. disease-control body. This week we finally learned that the source of this chaos and the sharp decline in the publics and health professionals confidence in the CDC has been a troubled Trump appointee, Michael Caputo, a far-right conspiracy-monger and protg of convicted felon Roger Stone.

It is dj vu all over again. In 1987, one of us (AB) would be told upon assuming a faculty position at Baylor College of Medicine that he could not use his academic affiliation when speaking publicly on smoking and that he should consider getting into something more socially acceptable, like cocaine.

This meant, of course, that studying illicit drugsnot cigaretteswas where the grant funding wasand dont you keep messing with the folks at the tobacco companies who have influence over Capitol Hill and the NIH!

One year later, he would be offered the editorship of the journal of the American Academy of Family Physicians, American Family Physiciancontingent on his not speaking publicly on the subject of smoking.

The AAFP was a recipient of advertising revenue from food subsidiaries of RJ Reynolds and Philip Morris. AB turned down the job.

What is the fairest way to compare strategies to contain the virus with the efforts to reduce cigarette smoking? Why not begin with those who are made ill by a known agent through no fault of their own, as well as through willfully misleading directives by elected officials?

The turning point in the effort to reduce cigarette smoking came in the early 1980s, when studies in Japan and Greece found that long-term exposure to cigarette smoke could cause lung cancer in a person who did not smoke.

Certainly, those individuals who were involuntarily exposed to cigarette smoke over many years at the workplace and who developed terminal lung cancer or emphysema would be unequivocal innocent victims of smoking.

What about those who contract COVID-19?

The only ones in this population who arent unequivocally innocent victims are those who refuse to wear masks, practice physical distancing, wash hands frequently, and refrain from participating in social gatherings, political rallies, or protest demonstrations.

Another way to look at smoking-related deaths is through the number of those who had chosen to continue to smoke in spite of knowing that it could kill them.

One could argue that nicotine addiction is too powerful to overcome, and that, therefore, all of the blame must be laid at the feet of tobacco industry executives and the leaders of allied businesses that have engaged in the promotion of cigarettes in spite of the dangers.

But what about the accountability of public health agencies, which are tasked both with curbing infectious outbreaks and improving the health of the entire population? If a commissioner of health were found to have failed to allocate funds to mosquito control after an outbreak of West Nile, dengue, St. Louis encephalitis, or zika, then that individual would be held partially responsible for the cases that resultedand criminally negligent if the funds were deliberately withheld because the commissioner didnt believe that mosquitoes were the vector, or if he or she pocketed the money.

Analogously, why shouldnt a health commissioner or health agency that chooses not to allocate funding to discourage smoking be held accountable for a failure to reduce tobacco-related deaths and diseases and/or cigarette consumption? Fanciful? But if the number one avoidable cause of death and disease in the health district doesnt receive sufficient funding, then why shouldnt there be accountability?

Although Surgeon General Luther Terry called for appropriate remedial action on smoking in 1964, it would be fully 25 years before every state had even a single individual assigned to reduce smoking.

Nor were health department commissioners permitted to endorse efforts to pass clean indoor air regulations to protect nonsmokers.

And what about academia, organized medicine, and the voluntary health organizations, such as the American Cancer Society? What did they do as the battles over restrictions on cigarette advertising heated up in the 1980s? Most were nowhere to be found.

Individual tobacco product liability lawsuits brought against the tobacco industry beginning in 1983 by New Jersey attorney Mark Edell (Cipollone v Liggett Tobacco Group Inc.), followed by class action suits brought by several state attorneys general in the mid-1990s, began to expose the myth of organized medicine as an enemy of Big Tobacco.

In a TV interview in 1996, the president of the American Medical Association, Lonnie Bristow, famously claimed, We were duped.

This is in spite of the AMA having accepted cigarette ads in its journal from the early-1930s to the mid-1950s, the same time period when the epidemiological and pathological research showing the association between smoking and disease was being published.

This was also in spite of the publication of the Surgeon Generals Report in 1964, following which the AMA, as noted here, spent 14 years conducting research funded by the tobacco industry in lieu of taking action or even calling for action against smoking, apart from advising the public not to smoke in bed.

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Brightseed raises $27m to support its phytonutrient discovery tech – FoodBev.com

Brightseed, the developer of an AI-powered phytonutrient discovery solution, has raised $27 million in a funding round led by Lewis & Clark AgriFood.

Founded in 2017, Brightseed has developed Forager, an AI solution that can reportedly search for undiscovered compounds in plants which provide proven health benefits, as well as searching for new benefits in existing plant-based products and ingredients.

In humans, phytonutrients such as lycopene and resveratrol support health by boosting anti-inflammatory, cardioprotective and neuroprotective activities. Brightseed claims that this latest investment follows Foragers discovery of a powerful phytonutrient with the potential to support metabolic health, helping those at risk of metabolic diseases such as diabetes, liver diseases and weight management issues.

This new financing round means Brightseed has now raised $52 million in total funding, after factoring in the $25 million raised in previous a funding round led by Seed 2 Growth Ventures, Horizons Ventures, CGC Ventures, Fifty Years, Germin8 Ventures, and AgFunder.

Brightseed has partnered with a number of major food companiesto trial the Forager platform. This includes a multi-phased partnership with Danone North America to find previously unknown health benefits of plant-based ingredients in Danones consumer products portfolio.

David Russell of Lewis & Clark AgriFood and Elaine Leavenworth, former SVP, and chief marketing and external affairs officer at Abbott, will join Brightseeds board of directors.

Jim Flatt, Brightseed co-founder and CEO, said: Were thrilled to work with visionary partners to accelerate innovation in food, health, and wellness.

Were in an unprecedented public health crisis, and people are looking for plant-based products that will contribute to a healthier life. With millions of phytonutrients hidden in plants, its crucial that we discover these compounds and understand how they help us.

Much like mapping the human genome opened up a new era for medicine, using Forager AI to map the connections between plants and people is one of the most exciting new frontiers of science.

Elaine Leavenworth, added: Brightseeds Forager AI is leading the search for natural phytonutrients that will provide dramatic health benefits.

Given todays health crises this has even greater urgency. Brightseed has the strong support of their investors and advisors as they move forward on this path.

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National Peanut Day 2020: The Amazing Health Benefits Of Peanut – Broadcast Cover

National Peanut Day happens on September 13, 2020. Peanuts are known by numerous other nearby names, for example, earthnuts, ground nuts, goober peas, monkey nuts, dwarf nuts and pig nuts. Notwithstanding its name and appearance, the nut isnt a nut, yet rather a vegetable. Peanuts are wealthy in supplements, giving more than 30 fundamental supplements and phytonutrients. Peanuts are a decent wellspring of niacin, folate, fiber, nutrient E, magnesium and phosphorus. They additionally are normally liberated from trans-fats and sodium, and contain about 25% protein.

Peanuts have numerous employments. They can be eaten crude, utilized in plans, made into solvents and oils, meds, material materials, and nutty spread, just as numerous different employments. In the US, peanuts are utilized in confections, cakes, treats, and different desserts. They are additionally delighted in cooked and salted. Nutty spread is one of the most mainstream nut based nourishments in the US, and for a long time, plans for nut soup have been available in the South, Virginia specifically. In some southern bits of the US, peanuts are bubbled for a few hours until delicate and sodden. Peanuts are likewise southern style, shell what not.

Despite the fact that the nut was predominantly a nursery crop for a great part of the provincial time of North America, it was generally utilized as creature feed stock until the 1930s. In the United States, a US Department of Agriculture program (see beneath) to empower rural creation and human utilization of peanuts was initiated in the late nineteenth and mid twentieth hundreds of years. George Washington Carver is notable for his support in that program in which he created many plans for peanuts.

1. Heart-accommodating

The presence of elevated levels of monounsaturated fats and polyunsaturated fats in peanuts help to keep the heart solid. Oleic corrosive in peanuts likewise assists with bringing down the terrible cholesterol and thus increment the great cholesterol levels in the blood, just to forestall coronary conduit illness and strokes by advancing sound blood lipid profile.

2. Brain food

It is because of the presence of nutrient B3 or niacin that improves the working of the cerebrum and further lifts memory. They likewise contain a flavonoid known as resveratrol that helps in improving blood stream to the cerebrum.

3. Helps weight reduction

The mix of fiber, fat and protein in peanuts helps keep you full for more and brings down your hunger. Along these lines, you avoid the pointless cravings for food and want less for shoddy nourishment that further prompts weight reduction. Peanuts are likewise a decent wellspring of vitality that help increment the metabolic rate.

4. Helps manage stress and anxiety

Stress and uneasiness are two manifestations of wretchedness; on account of the amino corrosive known as tryptophan present in peanuts, which helps in delivering serotonin, a cerebrum substance that is engaged with temperament guideline. This compound further aides in keeping you quiet and intellectually mindful.

5. One of the best snacks for diabetics

Peanuts make an incredible nibble alternative for diabetics because of the presence of manganese, a mineral that assumes a significant part in utilizing fat and starch, calcium retention and glucose guideline. They are known to have a low glycemic record that makes it an ideal go-to nibble for diabetics.

6. Useful for skin and hair

The monounsaturated fats and nutrients present in peanuts make them helpful for the skin. It is additionally known to contain nutrient C and E that help postpone noticeable indications of maturing. It likewise contains resveratrol that goes about as an intense enemy of maturing phytochemical, which additionally gives you clear and shining skin. Then again, peanuts are acceptable wellsprings of B-nutrients that convert in to biotin just to initiate hair development.

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National Peanut Day 2020: The Amazing Health Benefits Of Peanut - Broadcast Cover

Biochemist – Wikipedia

Scientist specialized in biochemistry

Biochemists are scientists that are trained in biochemistry.

Biochemists study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological chemist."

Biochemists also research how certain chemical reactions happen in cells and tissues[1] and observe and record the effects of products in food additives and medicines.

Biochemist researchers focus on planning and conducting research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create grant proposals to obtain funds for future research.[2]

Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to cancers, and manage laboratory teams and monitor laboratory work. Biochemists also have to have the capabilities of designing and building laboratory equipment and devise new methods of producing correct results for products.[3]

The most common industry role is the development of biochemical products and processes. Identifying substances' chemical and physical properties in biological systems is of great importance, and can be carried out by doing various types of analysis. Biochemists must also prepare technical reports after collecting, analyzing and summarizing the information and trends found.

In biochemistry, researchers often break down complicated biological systems into their component parts. They study the effects of foods, drugs, allergens and other substances on living tissues; they research molecular biology, the study of life at the molecular level and the study of genes and gene expression; and they study chemical reactions in metabolism, growth, reproduction, and heredity, and apply techniques drawn from biotechnology and genetic engineering to help them in their research. About 75% work in either basic or applied research; those in applied research take basic research and employ it for the benefit of medicine, agriculture, veterinary science, environmental science, and manufacturing. Each of these fields allows specialization; for example, clinical biochemists can work in hospital laboratories to understand and treat diseases, and industrial biochemists can be involved in analytical research work, such as checking the purity of food and beverages.

Biochemists in the field of agriculture research the interactions between herbicides with plants. They examine the relationships of compounds, determining their ability to inhibit growth, and evaluate the toxicological effects surrounding life.

Biochemists also prepare pharmaceutical compounds for commercial distribution.

Modern biochemistry is considered a sub-discipline of the biological sciences, due to its increased reliance on, and training, in accord with modern molecular biology. Historically, even before the term biochemist was formally recognized, initial studies were performed by those trained in basic chemistry, but also by those trained as physicians.

Some of the job skills and abilities that one needs to attain to be successful in this field of work include science, mathematics, reading comprehension, writing, and critical thinking. These skills are critical because of the nature of the experimental techniques that are used as well as the need to convey orally and written the trends found in research.

A degree in biochemistry or a related science such as chemistry is the minimum requirement for any work in this field. This is sufficient for a position as a technical assistant in industry or in academic settings. A Ph.D. (or equivalent) is generally required to pursue or direct independent research. To advance further in commercial environments, one may need to acquire skills in management.

Biochemists must pass a qualifying exam or a preliminary exam to continue their studies when receiving a Ph.D. in biochemistry.

Biochemistry requires an understanding of organic and inorganic chemistry. All types of chemistry are required, with emphasis on biochemistry, organic chemistry and physical chemistry. Basic classes in biology, including microbiology, molecular biology, molecular genetics, cell biology, and genomics, are focused on. Some instruction in experimental techniques and quantification is also part of most curricula.

In the private industries for businesses, it is imperative to possess strong business management skills as well as communication skills. Biochemists must also be familiar with regulatory rules and management techniques.[4]

Biochemistry Blog publishes high quality research articles, papers, posts and jobs related to biochemistry. Biochemistry 2019, biochemistry papers latest. [5]

Due to the reliance on most principles of the basic science of Biochemistry, early contemporary physicians were informally qualified to perform research on their own in mainly this (today also related biomedical sciences) field.

Biochemists are typically employed in the life sciences, where they work in the pharmaceutical or biotechnology industry in a research role. They are also employed in academic institutes, where in addition to pursuing their research they may also be involved with teaching undergraduates, training graduate students, and collaborating with post-doctoral fellows.

The U.S. Bureau of Labor Statistics (BLS) estimates that jobs in the biochemist, combined with the statistics of biophysicists, field would increase by 31% between 2004 and 2014 because of the demand in medical research and development of new drugs and products, and the preservation of the environment.

Because of a biochemists' background in both biology and chemistry, they may also be employed in the medical, industrial, governmental, and environmental fields. Slightly more than half of the biological scientists are employed by the Federal State and local governments. The field of medicine includes nutrition, genetics, biophysics, and pharmacology; industry includes beverage and food technology, toxicology, and vaccine production; while the governmental and environmental fields includes forensic science, wildlife management, marine biology, and viticulture.

The average income of a biochemist was $82,150 in 2017. The range of the salaries begin around 44,640 to 153,810, reported in 2017. The Federal Government in 2005 reported the average salaries in different fields associated with biochemistry and being a biochemist. General biological scientists in nonsupervisory, supervisory, and managerial positions earned an average salary of $69,908; microbiologists, $80,798; ecologists, $72,021; physiologists, $93,208; geneticists, $85,170; zoologists, $101,601; and botanists, $62,207.[6]

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Biochemist - Wikipedia

Scientist takes a closer look at the genome – University of Miami

With a $1.82 million grant, computer scientist and bioinformatic researcher Zheng Wang is poised to help researchers see every aspect of the genome in super-resolution 3D.

Breakthrough advances in biomedical technology have come a long way, especially with three-dimensional mapping of the structure of the genome. For years, scientists and researchers have attempted to obtain and analyze the entire 3D structure of an organism's DNA to observe and understand its complex organization and how the genes function and interact.

Now, by combining cutting-edge computer science techniqueswith leading biomedical technologies, computer scientist and bioinformatic researcher Zheng Wang ispoised to help researchers see every aspect of the genome in super-resolution 3D formalmost an impossibility through the microscopeto better interpret its biological meaning.

Wang, who specializes in bioinformatics research, an interdisciplinaryfield combining biology, statistics, and computer science, recently received a five-year, $1.82 million Maximizing Investigators' Research Award (MIRA), considered one of the most prestigious National Institutes of Health grants for outstanding investigators, to develop more complex computational algorithms that will enable closer looks at the 3D genome.

"This is very exciting news, said Wang. This award will help me develop a new 3D perspective for studying the genome. Over the next five years, I hope to develop computational algorithms toreconstruct the 3D genome structures of single cells and builddeep-learning algorithms toenhance the resolution of whats known as Hi-C, the biochemistry experiment for detecting spatial proximity between different parts of the genome.

Although Wang is the sole principal investigator of the award, he said he cannot do his work without collaborators. He already has enlisted the help of Miller School of Medicine neuroscientists Vance Lemmon and John Bixby. Their lab is providing samples of mouse genomes to help Wang examine the changes of the 3D genome structures during the regenerative process of damaged neuron cells.

The scientist is also using Hi-C data generated by other biochemistry labs that use human brain, liver, spleen, stomach, and cancer cells. Neither a computer program nor the Hi-C experiment can directly detect the 3D genome structure. But a biochemical wet lab can provide the cells, or Hi-C data, that will enable me to create the intelligent algorithms to build the 3D genome structures and then analyze them very, very closely, Wang explained.

The award also will help Wang answer scientific questions on how the structure of the genome influences gene regulation and other important biological processes of the cells, as well as the role of the long non-coding RNAs in the formation of genome structures.

The scientific question that fascinates me is why the 3D genomestructures are different and what consequences these differences will lead to, said Wang. With this award, I hope to answer fundamental and biological questions that can then be used when studying the genome. One of my goals is to help other scientists develop further research so that they can go deeper into the genome and be able to study specific diseases.

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Scientist takes a closer look at the genome - University of Miami

Postdoctoral studies on the molecular mechanisms that regulate aging – Nature.com

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Aging is one of the main risk factors for morbidity and mortality. Thus, a better understanding of the mechanisms that regulate this process is highly desirable. One of our efforts focuses on arguably the most important aging regulator known to date, the transcription factor DAF-16/FOXO. It resides downstream of the nutrient-sensing insulin/IGF signaling pathway and in response to low nutrients activates gene expression programs that slow down the aging process. DAF-16/FOXO depends on a diverse range of binding partners and regulators to fulfill its role, and we are studying their functions by diverse biochemical, genetic, and cytological techniques. (See Lin et al., Nature Communications 2018, or Sen et al., Nature Communications 2020, for examples of such work from our lab.)

Your mission

We are looking for a Postdoc to join our research group, the lab of Christian Riedel. Focus of this position is to explore a new binding partner of DAF-16/FOXO which we found to be required for DAF-16/FOXO to promote longevity in response to low nutrient signals. This work is conducted both in the model organism C. elegans and in human cells. You will synergize with aging biologists and bioinformaticians from the Riedel lab and be part of a larger aging-focused research environment at our department, which also contains the labs of Martin Berg and Maria Eriksson.

We are looking for a talented and highly motivated scientist with a doctoral degree and strong background in Molecular Biology, Cell Biology, Genetics, and/or Biochemistry. Good expertise in either C. elegans methods or in mammalian cell culture techniques is desired. Also, a background in the biology of aging is appreciated, even though it is not essential.

Applicants are expected to work independently but as part of an enthusiastic team and to be proficient in English. They are expected to play a leading role in the design and execution of their experiments as well as the analysis and the presentation/publication of the resulting data. Before and while being in the lab, the applicant will be encouraged to apply for competitive national and international postdoctoral fellowships and career grants and will receive support in those endeavors.

This position will be financed by a postdoc scholarship paid out by Karolinska Institutet.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the worlds leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden.

Location: Department of Biosciences and Nutrition, Neo Building, Flemingsberg

Links: https://ki.se/en/bionut/department-of-biosciences-and-nutrition https://ki.se/en/bionut/christian-riedel-group http://riedellab.org/

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

An application must contain the following documents in English:

You are welcome to apply at the latest by 16 October 2020.

The application has to be submitted through the Varbi recruitment system.

More here:
Postdoctoral studies on the molecular mechanisms that regulate aging - Nature.com