Biotechnology Market research, Industry Outlook, Current Trends and Forecast by 2025 – The Research Process

A new report on Biotechnology market that provides a comprehensive review of this industry with respect to the driving forces influencing the market size. Comprising the current and future trends defining the dynamics of this industry vertical, this report also incorporates the regional landscape of Biotechnology market in tandem with its competitive terrain.

Favorable government initiative and growing demand for synthetic biology will drive the biotechnology industry growth over the forecast timeframe. Also rising demand for agro-based products should fuel global biotechnology market growth.

Decreasing cost of DNA sequencing from last couple of decades owing to the advances in the field of genomics will stimulate the global biotechnology market. Furthermore, increasing scarcity of natural resources across the globe should propel the industry growth.

Request Sample Copy of this Report @ https://www.theresearchprocess.com/request-sample/6111

Biotechnology Market to exceed USD 775 billion by 2024 as per a new research report.

Request Sample Copy of this Report @ https://www.theresearchprocess.com/request-sample/6111

Bio-agriculture segment will show the significant growth due to the inadequacy of the natural resources to meet the requirement of increasing global population. Increased crop yield as well as profitability are some of the advantages of genetically modified plants owing to which the segment is predicated to show significant growth in near future.

Bio-industrial segment will show growth as improved micro-organisms and enzymes are showing wide range of applications in chemical industry. Increasing demand for biofuels due to high price of natural oil and environmental concerns associated with the traditional fuels will further boost the biotechnology market.

However, the risk of food allergy and increased toxicity associated with the genetically modified organism and crops will limit the market growth over the forecast timeframe.

The tissue engineering focus on developing the cure for different chronic diseases. Increasing prevalence of chronic diseases is expected to drive the demand for tissue engineering and regeneration segment. Increasing cost of organ transplant and organ shortage will further boost the market growth as biotechnology provides better alternatives through tissue engineering technology.

PCR technology plays a key role in the DNA and genomics related research aimed at developing the better treatment for chronic diseases such as heart diseases and cancer. Increasing application of PCR in the field of diagnostics and several other fields such as archeology will boost the growth of the segment.

Major Highlights from Table of contents are listed below for quick lookup into Biotechnology Market report

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Biotechnology Industry Insights

Chapter 4. Company Profiles

Request Customization on This Report @ https://www.theresearchprocess.com/request-for-customization/6111

Go here to read the rest:
Biotechnology Market research, Industry Outlook, Current Trends and Forecast by 2025 - The Research Process

Should You Buy Vir Biotechnology Stock on the Dip? – Motley Fool

One of the biggest winners among coronavirus stocks in 2020 has been Vir Biotechnology(NASDAQ:VIR). The company's shares have more than doubled in the span of one year, turning a $10,000 investment from last September into about $22,700 today. That substantially outperformed the S&P 500, which gained 15% over the same period.

But sometimes, the higher you climb, the harder you fall. Recent controversy surrounding the company's progress with its COVID-19 programs caused the stock to fall more than 40% from its peak in late August. Should investors expect this company and its stock to rebound? Let's take a look at whether buying Vir on the dip is a golden opportunity or whether the company's drug pipeline spells trouble for its future.

Image Source: Getty Images.

Vir has two antibody treatments and a small interfering RNA (siRNA) treatment against COVID-19 in its pipeline. siRNA therapeutic candidates are based on tiny double-stranded RNA sequences coded to destroy genetic material responsible for a virus' protein synthesis, rendering it unable to replicate. The RNA treatment is undergoing preclinical studies, the results from which are expected by the end of the year. Meanwhile, one of the company's antibodies, VIR-7832, will enter phase 2 clinical trials in the fourth quarter, while the other, VIR-7831, is in phase 2/3 clinical trials. The latter candidate could made available first under an early access program like an Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA) in the early months of 2021, if trial results are positive.

Vir has partnered with GlaxoSmithKline(NYSE:GSK) to develop its COVID-19 programs. The company is responsible for research and development (R&D) costs while GlaxoSmithKline is handling commercialization costs. Under the agreement, 72.5% of costs and profits go to Vir while the remaining 27.5% are GlaxoSmithKline's.

Without a doubt, Vir's pipeline has potential. However, there are already coronavirus treatments on the market, including Gilead Sciences'(NASDAQ:GILD) antiviral, remdesivir, and the generic steroid, dexamethasone. What's more, large-cap biotechs such as Moderna(NASDAQ:MRNA) andPfizer(NYSE:PFE) are already far along in their efforts to develop coronavirus vaccines. In fact, a vaccine could be available as soon as October. While there are no guarantees that any one of the vaccine candidates in particular will prove effective against COVID-19, it is likely that by 2022, the need for coronavirus treatments will have significantly diminished as people around the world are (hopefully) inoculated.

The company's hepatitis B pipeline is facing similar problems. Even though its treatment candidates for the disease are well into phase 2 trials, the question of their commercial feasibility is a key concern. There are already a number of effective hepatitis B vaccines available worldwide, meaning that the need for a treatment is limited to those who don't get immunized (or those whose immunizations are ineffective) and subsequently contract the virus. While 257 million people are currently living with hepatitis B, many are in developing nations and may not have the purchasing power to afford a pricey treatment course.

If that wasn't enough, Arrowhead Pharmaceuticals (NASDAQ:ARWR) andJohnson & Johnson (NYSE:JNJ) are also on their way to developing a treatment for hepatitis B. Clinical data for their candidate has looked solid. Whatever comes out of Vir's pipeline would have to compete with both existing standard-of-care treatments such as Entecavir and Tenofovir and new ones from other biotechs. This would significantly affect the company's pricing power in the event of its drug's approval.

Vir only brought in $67 million in combined licensing plus collaboration revenues in the past quarter. But currently, it has about $552.4 million in cash and investments, is operating at a net loss of $31.2 million per quarter, and has a $4.05 billion market cap. So in terms of its ability to keep moving forward with research and development, Vir's financial position is fair.

However, I don't think its shaky pipeline can justify its stock price, even after a recent decline. The market opportunities for hepatitis B and COVID-19 treatment candidates are too unstable and full of heavyweight pharma competitors. Buying Vir Biotechnology now could be like catching a falling knife. Investors looking at coronavirus stocks may wish to consider other opportunities.

Excerpt from:
Should You Buy Vir Biotechnology Stock on the Dip? - Motley Fool

Is Fate Therapeutics Inc (FATE) a Winner in the Biotechnology Industry? – InvestorsObserver

A rating of 82 puts Fate Therapeutics Inc (FATE) near the top of the Biotechnology industry according to InvestorsObserver. Fate Therapeutics Inc's score of 82 means it scores higher than 82% of stocks in the industry. Fate Therapeutics Inc also received an overall rating of 66, putting it above 66% of all stocks. Biotechnology is ranked 29 out of the 148 industries.

Finding the best stocks can be tricky. It isnt easy to compare companies across industries. Even companies that have relatively similar businesses can be tricky to compare sometimes. InvestorsObservers tools allow a top-down approach that lets you pick a metric, find the top sector and industry and then find the top stocks in that sector.

These scores are not only easy to understand, but it is easy to compare stocks to each other. You can find the best stock in an industry, or look for the sector that has the highest average score. The overall score is a combination of technical and fundamental factors that serves as a good starting point when analyzing a stock. Traders and investors with different goals may have different goals and will want to consider other factors than just the headline number before making any investment decisions.

Fate Therapeutics Inc (FATE) stock has gained 2.6% while the S&P 500 has fallen -1.39% as of 1:41 PM on Friday, Sep 18. FATE is up $0.96 from the previous closing price of $36.91 on volume of 636,100 shares. Over the past year the S&P 500 is up 10.09% while FATE is up 112.04%. FATE lost -$1.57 per share the over the last 12 months.

Click Here to get the full Stock Score Report on Fate Therapeutics Inc (FATE) Stock.

Read this article:
Is Fate Therapeutics Inc (FATE) a Winner in the Biotechnology Industry? - InvestorsObserver

2025 Food Biotechnology Market |Top Companies, Trends and Future Prospects Details for Business Development – The Research Process

New research report on Food Biotechnology market, which is a detailed analysis of this business space inclusive of the trends, competitive landscape, and the market size. Encompassing one or more parameters among product analysis, application potential, and the regional growth landscape, Food Biotechnology market also includes an in-depth study of the industry's competitive scenario.

Rising concern pertaining to global food insecurity in developing countries with rising population will propel the food biotechnology market. As per FDA, area under biotech crop production increased by 4.7 million hectares in 2017 due to higher commodity prices for consumable products and increasing demand in developing economies. India, Brazil, Pakistan, Mexico, Colombia, etc. have increased the area under genetically modified crop production to meet the rising demand with growing population.

Changing dietary patterns and growing demand for processed items has urged the food & beverage manufacturers to improve the nutritional content in their products. Global processed-food industry is estimated to be valued over USD 3.2 trillion in 2018 and 80% of agricultural products in the developed countries get processed and packaged. Strong demand for high-quality functional ingredients by food processing companies will create lucrative opportunities for food biotechnology market players over the forecast period.

Request Sample Copy of this Report @ https://www.theresearchprocess.com/request-sample/5455

Increasing technological advancements in food industry will drive the food biotechnology market. Shifting consumer focus towards food quality, taste, nutrition and shelf life will support demand for genetically modified plants and animals. Changing climatic conditions and farming loss are expected to support production of genetically modified crops. Growing concern pertaining to usage of pesticides and herbicides for the crop yield will support penetration of innovative technologies over the projected timeframe.

Request Sample Copy of this Report @ https://www.theresearchprocess.com/request-sample/5455

Transgenic crop is expected to observe growth over 9% in terms of revenue up to 2025. Factors such as low labor & production cost, reduced application of chemical inputs and better economic gains are among the key factors that will positively influence the segment growth. In addition, growing subcontract agreements between private firms and the farmers to boost genetically modified crops production, will foster overall food biotechnology market over the forecasted timeframe.

North America food biotechnology market is anticipated to hold over 29% share in 2018. U.S. is the largest producer of genetically modified crops for commercial purpose, thus supporting overall regional growth. More than 93% of the corn, soy and cotton cultivated in the country are genetically modified. About 70% of the processed food in the U.S. are manufactured using genetically modified ingredients. In addition, increasing demand for processed and packaged products owing to busy lifestyle will foster the regional food biotechnology market share.

Rapid expansion of beverage sector will also provide new growth opportunities in the food biotechnology market share. Fermentation is the key process used in beverage and bakery industry, thus creating new avenues for industry participants. Emerging middle-class consumers in developing economies with rapid urbanization is anticipated to propel implementation of biotechnology solutions in beverage sector. Increasing demand for high-quality & premium beverages accompanied rising disposable income will support manufacturers investment in new product development.

Global food biotechnology market is competitive in nature due to the presence of large multinational and regional players. Key industry participants include BASF SE, Bayer Crop Science AG, AquaBounty Technologies, Dow AgroSciences LLC, ABS Global, Arcadia Biosciences, BDF Ingredients Zuchem, Camson Bio Technologies Ltd and Monsanto. New product development, mergers and acquisition, geographical expansion are few strategies adopted by the participants.

Major Highlights from Table of contents are listed below for quick lookup into Food Biotechnology Market report

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Food Biotechnology Industry Insights

Chapter 4. Company Profiles

Request Customization on This Report @ https://www.theresearchprocess.com/request-for-customization/5455

Read this article:
2025 Food Biotechnology Market |Top Companies, Trends and Future Prospects Details for Business Development - The Research Process

Agricultural Biotechnology Market 2020 Growth Analysis, Opportunities Forecasts Report till 2025 By Top Companies- Syngenta AG, Monsanto, DuPont,…

This elaborate research report presented on Agricultural Biotechnology market is committed to present a deep-dive analysis of the product overview, sectioning details on decisive growth opportunities, development trends as well as growth deterrents, restricting growth at the world forum.

Our in-house research experts, subject matter experts and researchers have followed an extensive research analysis methodology, following stringent market research protocols such as the like of PESTEL and PORTERs Five Force analysis to arrive at logical deductions based on which market players and aspiring new entrants may witness seamless entry.

Leading Companies Reviewed in the Report are:

Syngenta AG, Monsanto, DuPont, Performance Plants Inc., Global Bio-Chem Technology Group, and ADAMA Agricultural Solutions are some of the key players in this industry

Get Exclusive Sample of Report on Agricultural Biotechnology market is available @ https://www.adroitmarketresearch.com/contacts/request-sample/113

Internal and external growth propellants inclusive of administrative initiatives, rigorous and aggressive investments made by various market participants, market players as well as aspiring new entrants seeking seamless integration in the global Agricultural Biotechnology market space are highly dominant alterations in global Agricultural Biotechnology market, opine our leading in-house R&D veterans and research analysts who invest in massive research activities.

This research report presentation gives complete access to highly discernable market specific developments in the realm of core development and growth facets, elaborating on vendor behavior as well as activity, complete with relevant information on market player investments and growth models that contribute towards a consistent growth trajectory in global Agricultural Biotechnology market.

Segment Assessment: Global Agricultural Biotechnology Market, 2020-25

This delicately orchestrated market representation, evaluating multiple factors and growth determinants are poised to assist high end growth directed business decisions in global Agricultural Biotechnology market.

The report. This decisive report presentation makes critical headways in defining the developments of the market comprising each of the segments and performance-based analysis across regions, besides also roping in significant details on country-specific performance.

Quick Read Table of Contents of this Report @ https://www.adroitmarketresearch.com/industry-reports/agricultural-biotechnology-market

DROT Review: Global Agricultural Biotechnology Market

Driver Analysis: This dedicated section of the report throws ample light on various favorable conditions and triggers prevalent in the market that induce optimum momentum

Threat & Barrier Diagnosis: This section of the report lends thoughts on distinctive evaluation and identification of market deterrents that stagnate high potential growth in the global Agricultural Biotechnology market

Opportunity Mapping: The section is highly incumbent in guiding market participants in diverting investments towards tapping new opportunities on both regional and global perspectives.

Report Investment a Logical Investment, Know Why?

* The report upholds a systematic presentation of all the tangible segments and their role in revenue optimization

* Further, the report also allows manufacturers and vendors to design appropriate investment discretion

* The report resonates critical findings on decisive factors such as downstream needs and requirement specifications as well as upstream product and service development

* The report aids in reader comprehension of the market based on dual parameters of value and volume.

* This report also helps market participants to organize R&D activities aligning with exact market requirements

Do You Have Any Query Or Specific Requirement? Ask to Our Industry [emailprotected] https://www.adroitmarketresearch.com/contacts/enquiry-before-buying/113

About Us :

Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a Markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable Market insights to help create opportunities that increase their revenues. We follow a code- Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

Contact Us :

Ryan JohnsonAccount Manager Global3131 McKinney Ave Ste 600, Dallas,TX75204, U.S.A.Phone No.: USA: +1 972-362 -8199/ +91 9665341414

Follow this link:
Agricultural Biotechnology Market 2020 Growth Analysis, Opportunities Forecasts Report till 2025 By Top Companies- Syngenta AG, Monsanto, DuPont,...

Is Ultragenyx Pharmaceutical Inc (RARE) the Top Pick in the Biotechnology Industry? – InvestorsObserver

The 63 rating InvestorsObserver gives to Ultragenyx Pharmaceutical Inc (RARE) stock puts it near the top of the Biotechnology industry. In addition to scoring higher than 76 percent of stocks in the Biotechnology industry, RAREs 63 overall rating means the stock scores better than 63 percent of all stocks.

Finding the best stocks can be tricky. It isnt easy to compare companies across industries. Even companies that have relatively similar businesses can be tricky to compare sometimes. InvestorsObservers tools allow a top-down approach that lets you pick a metric, find the top sector and industry and then find the top stocks in that sector.

Our proprietary scoring system captures technical factors, fundamental analysis and the opinions of analysts on Wall Street. This makes InvestorsObservers overall rating a great way to get started, regardless of your investing style. Percentile-ranked scores are also easy to understand. A score of 100 is the top and a 0 is the bottom. Theres no need to try to remember what is good for a bunch of complicated ratios, just pay attention to which numbers are the highest.

Ultragenyx Pharmaceutical Inc (RARE) stock is trading at $80.17 as of 1:39 PM on Friday, Sep 18, a decline of -$2.25, or -2.73% from the previous closing price of $82.42. The stock has traded between $80.00 and $84.80 so far today. Volume today is below average. So far 199,806 shares have traded compared to average volume of 323,592 shares.

Click Here to get the full Stock Score Report on Ultragenyx Pharmaceutical Inc (RARE) Stock.

See the original post:
Is Ultragenyx Pharmaceutical Inc (RARE) the Top Pick in the Biotechnology Industry? - InvestorsObserver

Is MannKind Corporation (MNKD) a Winner in the Biotechnology Industry? – InvestorsObserver

A rating of 86 puts MannKind Corporation (MNKD) near the top of the Biotechnology industry according to InvestorsObserver. MannKind Corporation's score of 86 means it scores higher than 86% of stocks in the industry. MannKind Corporation also received an overall rating of 70, putting it above 70% of all stocks. Biotechnology is ranked 29 out of the 148 industries.

Searching for the best stocks to invest in can be difficult. There are thousands of options and it can be confusing on what actually constitutes a great value. Investors Observer allows you to choose from eight unique metrics to view the top industries and the best performing stocks in that industry. A score of 70 would rank higher than 70 percent of all stocks.

Our proprietary scoring system captures technical factors, fundamental analysis and the opinions of analysts on Wall Street. This makes InvestorsObservers overall rating a great way to get started, regardless of your investing style. Percentile-ranked scores are also easy to understand. A score of 100 is the top and a 0 is the bottom. Theres no need to try to remember what is good for a bunch of complicated ratios, just pay attention to which numbers are the highest.

MannKind Corporation (MNKD) stock has gained 2.85% while the S&P 500 has fallen -0.51% as of 11:45 AM on Friday, Sep 18. MNKD is up $0.06 from the previous closing price of $1.93 on volume of 1,755,208 shares. Over the past year the S&P 500 is higher by 11.07% while MNKD is up 50.76%. MNKD lost -$0.21 per share the over the last 12 months.

Click Here to get the full Stock Score Report on MannKind Corporation (MNKD) Stock.

Go here to see the original:
Is MannKind Corporation (MNKD) a Winner in the Biotechnology Industry? - InvestorsObserver

Biotechnology Crop Seeds Market Projected To Show Massive Growth By 2028 With Major Players Bayer, Corteva, KWS SAAT, Limagrain, China National…

The Biotechnology Crop Seeds Market share was valued at USD 50.82 billion in 2019 and it is projected to reach USD 86.59 billion by 2028 growing at a CAGR of 6.1% during the forecast period, 2016-2028. The market for Biotechnology Crop Seeds market has been segmented in major regions to understand the global development and demand patterns in this market. The Biotechnology Crop Seeds market has been segmented in North America, Eastern Europe, Western Europe, Asia Pacific, Middle East, & the Rest of the World.

Sample Copy of This Report: https://www.quincemarketinsights.com/request-sample-68404?utm_source=Radhika/DC

With an emphasis on strategies, there have been several primary developments done by major companies such as Bayer, Corteva, KWS SAAT, Limagrain, China National Chemical

In terms of revenue and consumption of Biotechnology Crop Seeds, the Asia Pacific held a major market share globally in 2019. The Asia Pacific is expected to emerge as a relatively fast-growing region owing to the increasing demand from the paints & coating industry along with the growth in wood and plastic industries.

The market has been segmented as: By Product Type (Herbicide Tolerant, Insect Tolerant), By Application (Corn, Soybean)

Get ToC for the overview of the premium report @ https://www.quincemarketinsights.com/request-toc-68404?utm_source=Radhika/DC

This comprehensive market analysis explores market growth potential for Biotechnology Crop Seeds market that can help the stakeholders understand key developments and expectations in the market for Biotechnology Crop Seeds market-defining opportunities for growth and competitive scenarios. Moreover, the utilization of those products in industrial applications is beneficial for the reduction of cost and ensure fast cycle time.

Some of the key Impact Factors:

Make an Enquiry for purchasing this Report @ https://www.quincemarketinsights.com/enquiry-before-buying-68404?utm_source=Radhika/DC

ABOUT US:

QMI has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the worlds most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

Contact:

Quince Market Insights

Office No- A109

Pune, Maharashtra 411028

Phone: APAC +91 706 672 4848 / US +1 208 405 2835 / UK +44 1444 39 0986

Email: [emailprotected]

Web: http://www.quincemarketinsights.com

See the rest here:
Biotechnology Crop Seeds Market Projected To Show Massive Growth By 2028 With Major Players Bayer, Corteva, KWS SAAT, Limagrain, China National...

Is OncoCyte Corp (OCX) the Top Pick in the Biotechnology Industry? – InvestorsObserver

A rating of 22 puts OncoCyte Corp (OCX) near the bottom of the Biotechnology industry according to InvestorsObserver. OncoCyte Corp's score of 22 means it scores higher than 22% of stocks in the industry. OncoCyte Corp also received an overall rating of 34, putting it above 34% of all stocks. Biotechnology is ranked 29 out of the 148 industries.

Analyzing stocks can be hard. There are tons of numbers and ratios, and it can be hard to remember what they all mean and what counts as good for a given value. InvestorsObserver ranks stocks on eight different metrics. We percentile rank most of our scores to make it easy for investors to understand. A score of 34 means the stock is more attractive than 34 percent of stocks.

These rankings allows you to easily compare stocks and view what the strengths and weaknesses are of a given company. This lets you find the stocks with the best short and long term growth prospects in a matter of seconds. The combined score incorporates technical and fundamental analysis in order to give a comprehensive overview of a stocks performance. Investors who then want to focus on analysts rankings or valuations are able to see the separate scores for each section.

OncoCyte Corp (OCX) stock is up 3.23% while the S&P 500 has fallen -0.51% as of 11:36 AM on Friday, Sep 18. OCX has gained $0.05 from the previous closing price of $1.55 on volume of 271,925 shares. Over the past year the S&P 500 is higher by 11.07% while OCX has fallen -27.27%. OCX lost -$0.51 per share the over the last 12 months.

Click Here to get the full Stock Score Report on OncoCyte Corp (OCX) Stock.

More:
Is OncoCyte Corp (OCX) the Top Pick in the Biotechnology Industry? - InvestorsObserver

Is Hepion Pharmaceuticals Inc (HEPA) The Right Choice in Biotechnology? – InvestorsObserver

The 65 rating InvestorsObserver gives to Hepion Pharmaceuticals Inc (HEPA) stock puts it near the top of the Biotechnology industry. In addition to scoring higher than 82 percent of stocks in the Biotechnology industry, HEPAs 65 overall rating means the stock scores better than 65 percent of all stocks.

Finding the best stocks can be tricky. It isnt easy to compare companies across industries. Even companies that have relatively similar businesses can be tricky to compare sometimes. InvestorsObservers tools allow a top-down approach that lets you pick a metric, find the top sector and industry and then find the top stocks in that sector.

This ranking system incorporates numerous factors used by analysts to compare stocks in greater detail. This allows you to find the best stocks available in any industry with relative ease. These percentile-ranked scores using both fundamental and technical analysis give investors an easy way to view the attractiveness of specific stocks. Stocks with the highest scores have the best evaluations by analysts working on Wall Street.

Hepion Pharmaceuticals Inc (HEPA) stock has gained 7.06% while the S&P 500 is down -1.54% as of 11:45 AM on Thursday, Sep 17. HEPA has risen $0.24 from the previous closing price of $3.40 on volume of 759,104 shares. Over the past year the S&P 500 has risen 10.86% while HEPA has risen 20.53%. HEPA lost -$2.61 per share the over the last 12 months.

Click Here to get the full Stock Score Report on Hepion Pharmaceuticals Inc (HEPA) Stock.

Read the original:
Is Hepion Pharmaceuticals Inc (HEPA) The Right Choice in Biotechnology? - InvestorsObserver

Seattle AVM Biotechnology announces second IND for AVM0703: clinical trial permitted to treat COVID-19 and Influenza ARDS with its…

SEATTLE, Sept. 16, 2020 /PRNewswire/ -- AVM Biotechnology has received FDA permission to proceed with clinical trials to evaluate its proprietary drug AVM0703 in the treatment of Acute Respiratory Distress Syndrome (ARDS) mediated by COVID-19 or Influenza patients. This is AVM's second "safe to proceed" clinical trial authorization from the FDA within the past six months and demonstrates the broad potential of AVM's lead drug.

The previously approved study will evaluate AVM0703 in refractory/relapsed Non-Hodgkin's Lymphoma patients. This second study consists of two different ARDS patient populations: one with COVID-19-mediated moderate to severe ARDS and the other with Influenza-mediated severe ARDS.

AVM0703 is a novel and proprietary formulation of high concentration of dexamethasone. In addition to its recognized immunomodulatory properties, an acute high or suprapharmacologic dose of AVM0703 mobilizes highly active Natural Killer T- (NKT) and cytotoxic T- cells and dendritic cells. Within 6 hours of a single administration, there is evidence that AVM0703 "kick-starts" additional NKT cell activation. These cells have robust activity against very aggressive difficult-to-treat cancer models; this is directly relevant to COVID-19- and Influenza-mediated ARDS because NKT cells are programmed to eliminate abnormal cells, whether cancer or virus-infected.

Although generic formulations of dexamethasone are available, and daily low dosing has become a standard of care for moderately to severely ill COVID-19 patients, generic dexamethasone cannot be used at the high doses necessary to activate Natural Killer T (NKT), cytotoxic T and dendritic cells, and to stimulate monocyte ablation and reduce neutrophils. The excipients in these generic formulations exceed safe levels at the required doses needed to activate these immune cells. Importantly, one single dose of AVM0703 triggers this critical immune system activation.

While vaccines may play a part in thwarting COVID-19, it is entirely possible that COVID-19 infection will still occur in a significant number of people. Even with Influenza vaccines and antiviral drugs, a minimum of 17,000 Influenza patients develop ARDS in the USA each year. Therefore, therapies such as AVM0703 will most likely play a critical and continuing role in the future treatment of these patients.

"Quickly harnessing the body's own immune system to produce its own Natural Killer and cytotoxic T-cells and its own dendritic cells is appealing on many levels in treating seriously ill patients. Doing so has potentially broad applications in other diseases, including cancers." Janet R. Rea, AVM Biotechnology COO.

Rapid elimination of infected monocytes in COVID-19 patients could reduce ICU stays and decrease long-term lung damage. NKT mobilization could also provide long-term T-cell immunity. Due to its striking immunomodulatory properties, AVM0703 may have therapeutic effects in a variety of blood cancers, solid tumors, and infectious diseases such as COVID-19 and Influenza. Because NKT cells eliminate virus-infected cells independent of the strain or type of virus, this could provide immediately available therapy for future pandemics from any virus.

AVM Biotechnology is led by Dr. Theresa Deisher, a biotech veteran with a productive history including 47 patents and three discoveries in clinical trials. Its COO, Janet R. Rea, has a proven track record working with federal regulators and successfully bringing drugs to market. The Executive Board is comprised of world leaders in the areas of respiratory illness, regulatory affairs, and vaccine development, and AVM is guided by a global Advisory Board including well-respected leaders in the areas of cancer and immunology. The company has received two SBIR grants, has filed for five worldwide Methods of Use patent families, has a worldwide Composition of Matter patent pending, and is committed to developing products that improve outcomes without additional suffering. They believe side effects from treatments should never be worse than the diseases themselves. This approval to begin an additional trial utilizing AVM0703 to treat ARDS patients is an exciting further step in support of that mission.

For more information, please contact Jena Dalpezjdalpez@avmbiotech.com

This contains certain statements that constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These statements do not relate strictly to historical or current facts and they may be accompanied by words such as "could," "would," "may," "potentially," "suggest," "believes," "expects," "should," and similar words or expressions. These forward-looking statements reflect our current views as of the date this is published, and are subject to risks, uncertainties, assumptions, changes in circumstances, and other factors; drug development and commercialization are highly risky and early clinical results in animals or humans may not reflect the full results from later stage or larger scale clinical trials. These forward-looking statements are subject to risks and uncertainties that could cause our actual results, performance, and expectations to differ materially from those expressed or implied by these statements, including statements about: future and ongoing drug development and timing; the applications of drugs to specific diseases; the potential for ongoing preclinical or clinical trial results; FDA or other regulatory findings and approvals; potential market opportunities; and the occurrence of future events or circumstances. There are risks and uncertainties involving and not limited to our ability to progress in our research and development efforts, complete clinical testing, achieve our expected results, commercialize our products, avoid infringement of patients, trademarks and other proprietary rights of third parties, protect products from competition, navigate the political environment, maintain sufficient capital and funding, avoid problems with our manufacturing processes, maintain our operations, and obtain regulatory approval to sell and market the drugs in the United States and elsewhere. The reader should not place any undue reliance on such forward-looking statements. We have no obligation to release publicly the results of any revisions to any of our forward-looking statements to reflect events or circumstances after the date these statements are made or to reflect the occurrence of unanticipated events, except as may be required by law.

View original content to download multimedia:http://www.prnewswire.com/news-releases/seattle-avm-biotechnology-announces-second-ind-for-avm0703-clinical-trial-permitted-to-treat-covid-19-and-influenza-ards-with-its-supercharged-version-of-dexamethasone-301131932.html

SOURCE AVM Biotechnology, LLC

See original here:
Seattle AVM Biotechnology announces second IND for AVM0703: clinical trial permitted to treat COVID-19 and Influenza ARDS with its...

Vir Biotechnology Inc. (VIR) market price of $32.01 offers the impression of an exciting value play – The InvestChronicle

At the end of the latest market close, Vir Biotechnology Inc. (VIR) was valued at $32.96. In that particular session, Stock kicked-off at the price of $32.36 while reaching the peak value of $34.08 and lowest value recorded on the day was $31.29. The stock current value is $32.01.

Recently in News on September 9, 2020, Vir Biotechnology to Present at Cantor Global Virtual Healthcare Conference. Vir Biotechnology, Inc. (Nasdaq: VIR), a clinical-stage immunology company focused on treating and preventing serious infectious diseases, today announced that Phil Pang, M.D., Ph.D., chief medical officer of Vir will present at the Cantor Global Virtual Healthcare Conference on Tuesday, September 15th at 8:20 am PT/ 11:20 am ET. You can read further details here

Price records that include history of low and high prices in the period of 52 weeks can tell a lot about the stocks existing status and the future performance. Presently, Vir Biotechnology Inc. shares are logging -57.32% during the 52-week period from high price, and 174.75% higher than the lowest price point for the same timeframe. The stocks price range for the 52-week period managed to maintain the performance between $11.65 and $75.00.

The companys shares, operating in the sector of Healthcare managed to top a trading volume set approximately around 1815527 for the day, which was evidently higher, when compared to the average daily volumes of the shares.

When it comes to the year-to-date metrics, the Vir Biotechnology Inc. (VIR) recorded performance in the market was 154.55%, having the revenues showcasing -14.23% on a quarterly basis in comparison with the same period year before. At the time of this writing, the total market value of the company is set at 4.05B, as it employees total of 253 workers.

During the last month, 4 analysts gave the Vir Biotechnology Inc. a BUY rating, 0 of the polled analysts branded the stock as an OVERWEIGHT, 1 analysts were recommending to HOLD this stock, 1 of them gave the stock UNDERWEIGHT rating, and 1 of the polled analysts provided SELL rating.

According to the data provided on Barchart.com, the moving average of the company in the 100-day period was set at 40.11, with a change in the price was noted -1.04. In a similar fashion, Vir Biotechnology Inc. posted a movement of -3.15% for the period of last 100 days, recording 1,363,658 in trading volumes.

Total Debt to Equity Ratio (D/E) can also provide valuable insight into the companys financial health and market status. The debt to equity ratio can be calculated by dividing the present total liabilities of a company by shareholders equity. Debt to Equity thus makes a valuable metrics that describes the debt, company is using in order to support assets, correlating with the value of shareholders equity The total Debt to Equity ratio for VIR is recording 0.00 at the time of this writing. In addition, long term Debt to Equity ratio is set at 0.00.

Raw Stochastic average of Vir Biotechnology Inc. in the period of last 50 days is set at 17.44%. The result represents downgrade in oppose to Raw Stochastic average for the period of the last 20 days, recording 18.61%. In the last 20 days, the companys Stochastic %K was 18.00% and its Stochastic %D was recorded 15.66%.

Bearing in mind the latest performance of Vir Biotechnology Inc., several moving trends are noted. Year-to-date Price performance of the companys stock appears to be pessimistic, given the fact the metric is recording 154.55%. The shares increased approximately by 13.19% in the 7-day charts and went up by -39.55% in the period of the last 30 days. Common stock shares were lifted by -14.23% during last recorded quarter.

Continued here:
Vir Biotechnology Inc. (VIR) market price of $32.01 offers the impression of an exciting value play - The InvestChronicle

Where Does OncoSec Medical Inc (ONCS) Stock Fall in the Biotechnology Field? – InvestorsObserver

OncoSec Medical Inc (ONCS) is around the top of the Biotechnology industry according to InvestorsObserver. ONCS received an overall rating of 68, which means that it scores higher than 68 percent of all stocks. OncoSec Medical Inc also achieved a score of 88 in the Biotechnology industry, putting it above 88 percent of Biotechnology stocks. Biotechnology is ranked 31 out of the 148 industries.

Finding the best stocks can be tricky. It isnt easy to compare companies across industries. Even companies that have relatively similar businesses can be tricky to compare sometimes. InvestorsObservers tools allow a top-down approach that lets you pick a metric, find the top sector and industry and then find the top stocks in that sector.

These scores are not only easy to understand, but it is easy to compare stocks to each other. You can find the best stock in an industry, or look for the sector that has the highest average score. The overall score is a combination of technical and fundamental factors that serves as a good starting point when analyzing a stock. Traders and investors with different goals may have different goals and will want to consider other factors than just the headline number before making any investment decisions.

OncoSec Medical Inc (ONCS) stock is trading at $3.67 as of 1:07 PM on Monday, Sep 14, an increase of $0.40, or 12.23% from the previous closing price of $3.27. The stock has traded between $3.23 and $3.76 so far today. Volume today is 320,627 compared to average volume of 323,190.

Click Here to get the full Stock Score Report on OncoSec Medical Inc (ONCS) Stock.

Read more here:
Where Does OncoSec Medical Inc (ONCS) Stock Fall in the Biotechnology Field? - InvestorsObserver

God, Brad Pitt Is So Good at This – Vulture

Hes a master class in how to play the game as a celebrity. Case in point: his Fast Times at Ridgemont High table-read performance. Photo: CORE/YouTUbe

To succeed at celebrity is to master the art of image construction and management. It is to turn yourself into a brand in which performance is the method and the point. The step and repeat on the red carpet. The reaction to a seemingly impromptu paparazzi swarm. The interviews. The magazine covers. The charity events. Its all in service of an image created, not born. Throughout the history of Hollywood, there have been figures who buckled against the weight of the personas they walked behind, like Errol Flynn and Lana Turner during the height of the studio system. There have been others whose image-making was so refined as to make it hard to tell where the real person began and the star ended, la Archibald Leach, better known as the debonair Cary Grant. After the fall of the classic studio system in the 1960s, much changed in the imagination of what Hollywood could be. Chiefly, stars were free agents unwed to a single studio. But the tricksy, mercurial alchemy that goes into becoming and remaining a star endured. No one has proved more adept at playing this game lately than Brad Pitt.

In the wake of his contentious, ongoing divorce from Angelina Jolie on the heels of their grand, volcanic romance that bloomed on the set of Mr. and Mrs. Smith, when he was still married to Jennifer Aniston, causing a tabloid obsession that continues to this day 15 years later Pitt has played the celebrity game with slippery splendor. While Jolie has kept relatively quiet, Pitt has been more forward-facing. His star persona is that of the high-school quarterback: charismatic and beloved. (If anything, Hollywood at large comes across as a more knotted version of petty high-school politics anyway.) Pitt hasnt played the game perfectly so much as invisibly his relationship with his new 27-year old girlfriend, whom he took to the chateau he shared with Jolie, might read like a rote, midlife-crisis sort of scenario. And one of the most cunning turns in Pitts recent approach to his own image is to once again position himself in solidarity with his ex-wife, Jennifer Aniston, an alliance that bloomed during the 20192020 awards season, perhaps helping him nab an Academy Award for his supporting performance in Once Upon a Time in Hollywood. Now, in the middle of a pandemic, hes sidling up to Aniston once more, for a recent Fast Times at Ridgemont High table read.

What better way to shore up goodwill than painting yourself as the breezy, charming man who easily spends time with an ex-wife with whom people are still obsessively hold out hope youll reunite? Hi, Aniston, he croons. Hi, Pitt she replies before calling him honey. I could practically feel the heat index increase on Twitter in that moment. Personally, I have never been invested in the Pitt and Aniston relationship; I was far more intrigued by the sexual heat and emotional complexity between Pitt and Jolie. But the dynamic between Pitt and Aniston demonstrates the ways in which the personal can be leveraged for the professional for celebrities. And Pitt isnt just good at it, he ranks as one of the best, a talent fully on display during this table read. Hes more than merely charming, hes a supernova of lightning-bright presence. Hes more than willing to be silly and carefree, listening with full-bodied attention. Its a way of being hes mastered, that helps him to create indelible moments in celebrity history, like his suburban-themed photo shoot of curdled domestic bliss with Jolie in the pages of a 2005 issue of W magazine and now this video alongside Julia Roberts and Morgan Freeman. Pitts unique skill comes in how effortless he makes everything look, which takes his star image away from feeling studied and makes it seem natural. Every celebrity is playing the same game. But the ones who make it seem like they arent performing, and instead are speaking directly to us with some conspiratorial intimacy, are able to carve the kind of immortality actors dream of.

View post:
God, Brad Pitt Is So Good at This - Vulture

Woodburn: Every town has its own ‘Moonlight’ – VC Star

Woody Woodburn, Columnist Published 8:56 a.m. PT Sept. 18, 2020

As long as Shoeless Joe Jackson and the other ballplayers in the movie Field of Dreams stay on the magical baseball diamond in an Iowa cornfield, they remain forever young.

We learn this when young outfielder Moonlight Graham steps across the first-base foul line and becomes his elderly self as Dr. Archibald Graham, giving up immortality in order to save Ray Kinsellas young daughter from choking.

In response to my column last week, readerLindsay Nielson shared a humorous anecdote about feeling like he had crossed the foul line in the opposite direction during his annual physical with Dr. Geoff Loman.

I told him, Doc, I think I am immortal, Nielson wrote in an email. Really? Why is that?came his response.

I rattled off all the things I had been through two heart attacks; a fall that resulted in three screws to hold my hip together and a titanium bar in my femur; a few stent implants; back surgery that resulted in eight screws in my spine; and my second home in Palm Springs had burned to the ground, etc.

Dr. Loman said, Wow, Lindsay, that is something. But, I went to a pretty good medical school and it is my opinion that you probably arent immortal.

As the mortal Dr. Graham, Burt Lancasters character sagely says of his disappointing one-game career in the Big Leagues without an at-bat: If Id only gotten to be a doctor for five minutes now thatwould have been a tragedy.

Rick Throckmorton feels it would have been a tragedy had his own family doctor not had a long medical career, writing: Your column brought back old memories of Dr. Albert Crites, who founded the Port Hueneme Belinda Hospital, later Adventist Hospital. I dont know if he was a poet or not, but I remember him as surely being an angel or saint in disguise on earth.

Dr. Crites treated my grandmother, who was a sad hypochondriac, and who visited him almost daily with her alleged aches and pains. Once, I accompanied her while I was on a leave from the Army. I remember him saying, Bessie, now you know theres nothing wrong with you, but I have something that might help. Its a wonder medicine. He would give her a vial of what I later learned were plain sugar pills, but Grandmom was always better after taking them!

Dr. Crites once fixed my broken finger (before splinting it) by pulling it straight after telling me, Ricky, this is gonna hurt a little! I was in the seventh grade and a fly ball had hit squarely on top of my ring finger and broke it to 90 degrees. It hurt like heck, but Dr Crites soothing words calmed the tears.

Some years later, I was involved in a serious accident while in Hueneme High School and the ambulance took me to Adventist Hospital. I had not seen Dr. Crites since the broken-finger incident and there he was. He said again, Ricky, looks like this is gonna to hurt a little as he treated my severe burns.

Dr. Crites took care of my mom, too, as she had to have full hysterectomy; and my WWII veteran dads bad heart; and I was there with Dr. Crites when dad passed away early from a massive heart attack.

In the movie Field of Dreams, James Earl Jones character Terence Mann says, Every town has a Doctor Graham, Throckmorton concluded. Andevery town has, or should have, a Doctor Crites.

If not, now thatwould be a tragedy.

Woody Woodburn writes a weekly column for The Star and can be contacted atWoodyWriter@gmail.com. His books are available atwww.WoodyWoodburn.com.

Read or Share this story: https://www.vcstar.com/story/opinion/columnists/2020/09/18/woodburn-every-town-has-its-own-moonlight/3482855001/

Continued here:
Woodburn: Every town has its own 'Moonlight' - VC Star

Dating in the Kitchen cast: Meet the stars of the latest hit Chinese drama – HITC – Football, Gaming, Movies, TV, Music

The first season of Dating in the Kitchen has just premiered on Tencent Video, but who are the cast of this new romantic-comedy-drama?

If you are a fan of romantic-comedy dramas, Dating in the Kitchen is definitely a series you should check out.

The first season has only just debuted on Tencent Video, but fans are already falling in love with the characters as they start to fall for each other, but who are the stars of the show?

Zhao Lu Si (English name Rosy Zhao) is a popular Chinese actress from Chengdu in Sichuan Province.

Viewers will recognise Rosy from her roles in Untouchable Lovers (2018) as Ma Xue Yun, Oh! My Emperor (2018) as Luo Fei Fei, I Hear You (2019) as Bei Er Duo, Love of thousand Years (2020) as Qin Chuan and in The Romance of Tiger and Rose (2020) as Chen Xiao Qian.

The 21-year-old has also appeared in Love Better Than Immortality (2019), Prodigy Healer (2019), Autumn Fairy Tale (2019) and Cinderella Chef (2018).

Rosy is set to have a busy few years ahead of her, with main roles in The long Ballad (2020), A Female Student Arrives at the Imperial College (2021), Please Feel At Ease Mr. Ling (2021) and New Generation (2021).

You can follow Rosy on Instagram @rosy.zls.

This content could not be loaded

Lin Shen (also known as Lin Yushen) is a popular Chinese actor from Longyan in Fujian who has appeared in a variety of blockbuster movies and television shows.

The 39-year-old is best known for his performances in Heavenly Sword and Dragon Slaying (2019) as Yang Xiao, If Paris Downcast (2018) as Dai King Jie, Under Cover (2017) as Bao Yu, To Love Somebody (2014) as Lin Fan and Crazy in Love (2007) as Ah Kang.

Shen has also appeared in The Twin Flower Legend (2020), Im Lucky (2017), Flower Pinellia (2013), Single Child (2013), Stand By Me (2011) and The Frightening Night (2011), amongst many others.

Shen will play the main role in the upcoming drama Detective A & B, which premieres in 2021.

Visit link:
Dating in the Kitchen cast: Meet the stars of the latest hit Chinese drama - HITC - Football, Gaming, Movies, TV, Music

How To Support Racial Justice, Diversity And Activism This Weekend In Louisville (9/18) – Louisville Eccentric Observer

FRIDAY, Sept. 18

Old School FridaysThe Palm RoomNo cover | 5 p.m.-closeJoes Palm Room, the famous Russell jazz club, has been reopened and reinvented by Black business owner Marcus Withers. Check it out at the Palm Rooms new, weekly event, Old School Fridays, featuring The Palm Room House Band and happy hour from 5 to 9 p.m. and music and live visuals from DJ K-Dogg from 9 p.m. to close. Calling all steppers and ballroom dancers, organizers say.

Arrest the Cops RallyOffice of the Attorney General, Louisville Branch OfficeFree | 5:30 p.m.Protesters, led by the family of Breonna Taylor, are rallying at the Kentucky Attorney Generals Office to demand that the police officers who fired their weapons in the raid that led to Breonna Taylors death are arrested. This event is also organized by Until Freedom and Louisville activists.

Statements After an Arrest Under the Immortality ActOnlineFree | 8 p.m.UofLs Department of Theatre Arts presents this reading of a play about a white librarian and a Black school principal in South Africa, whose love affair is reported to the police during apartheid. You can watch virtually on Friday or on Saturday at the same time. After the performance, there will be talkbacks with specials guests. On Friday, hear from Actors Theatre of Louisville Executive Artistic Director Robert Barry Fleming, playwright and translator Amlin Gray and UofL Associate Dean for Diversity, Equity and Inclusion Cherie Dawson-Edwards. And, on Saturday, playwright Larry Muhammad, former South African resident Shachaf Polakow and UofL law professor Enid Trucious-Haynes, will discuss the show.

Voter Services Pop-upPortland KrogerFree | 11 a.m.-1 p.m.The Louisville Democrats will have a booth at the Portland Kroger offering help for voters. You can get started on requesting an absentee ballot, register to vote and, if youre formerly incarcerated, volunteers can check to see if your voting right has been restored. Then, on Sunday, the League of Women Voters is sponsoring a rally encouraging the public to vote. Bring noisemakers and signs to the corner of Douglass Boulevard and Eastern Parkway from 4 to 6 p.m. (The event is nonpartisan; organizers ask that you do not bring signs promoting specific candidates.)

Taking Up Space: Art as BusinessChange Today, Change TomorrowFree | 7-10:30 p.m.This is a new, monthly networking and educational space for Black creatives, created by Change Today, Change Tomorrow and A Well Written Photograph. This month, Ashley Cathey, a Louisville painter, will speak about Art as a Business over free cocktails and food from My Cafe, a locally-owned Back eatery.

See the original post:
How To Support Racial Justice, Diversity And Activism This Weekend In Louisville (9/18) - Louisville Eccentric Observer

The Water Man | TIFF 2020 Review | The GATE – The GATE

With his feature directorial debut, the Spielbergian family adventure and drama The Water Man, actor David Oyelowo shows that he might have a true knack for big budget blockbuster filmmaking. An unabashed love letter to young adult literature and the slightly-scary coming of age stories that were all the rage in the 1980s, The Water Man is a moving, well performed, and gorgeously shot effort that should entertain viewers of almost any age.

Twelve-year-old bookworm and budding graphic novelist Gunner Boone (Lonnie Chavis) sets aside his dream of writing a detective series when he learns his mother (Rosario Dawson) is battling an aggressive form of leukemia. With his father (Oyelowo) not offering much support, Gunner puts all his bookish efforts into trying to find a cure for moms suffering. One day, he stumbles upon a young girl named Jo (Amiah Miller) telling a bunch of kids about her encounter with a mythological legend known as The Water Man, an immortal humanoid creature that dwells in the forests. Gunner goes down another rabbit hole of research and begs Jo to help him find The Water Man, believing that the mythological beings immortality holds the key to curing his mothers cancer.

Oyelowo and screenwriter Emma Needell refuse to take easy or hammy shortcuts with their story, instead preferring old school, layered storytelling and character work over jump scares, set pieces, and teary eyed manipulation. Unlike many family films pitched at a similar level, The Water Man (executive produced by Oprah Winfrey) comes about its adventure and heart-tugging emotions naturally, with Oyelowo preferring to focus on performance and story. Its a story that couldve been cheesy in lesser hands, but Oyelowo and his young stars who boast exceptional chemistry together have crafted a genuine, cynicism-free bit of wonderment.

The Water Man is nostalgic and modernist in equal measure, with lots of nice touches that enhance the overall tone and entertainment value. Theres some clever use of animation, delightful supporting performances from acting luminaries Alfred Molina and Maria Bello (as a local historian and the town sheriff, respectively), and it builds to a perfect emotional payoff. Hopefully this film finds the audience it deserves, because The Water Man has the potential to be a family movie classic in the making.

The Water Man screens at the 2020 Toronto International Film Festival outdoors at the Visa Skyline Drive-In at Cityview on Saturday, September 19 at 7:30 pm and indoors at TIFF Bell Lightbox on Saturday, September 19 at 4:00 pm. It will also be available to stream online for a limited time during TIFF 2020 via Bell Digital Cinema starting at 6:00 pm on Saturday, September 19. All online screenings during TIFF 2020 are geolocked to Canada. If seeing a film in cinemas, please take all necessary precautions. Practice social distancing, wear a mask, and stay home if feeling ill.

Subscribe to our mailing list and get interesting stuff and updates to your email inbox.

Thank you for subscribing.

Something went wrong.

Read more from the original source:
The Water Man | TIFF 2020 Review | The GATE - The GATE

Cubs: 3 players whose futures with team are doomed after shortened season – Cubbies Crib

Use your (arrows) to browse

Cubs pitcher Tyler Chatwood has likely thrown his last pitch for the team. (Photo by Duane Burleson/Getty Images)

Despite carrying the second-best record in the National League into Wednesday nights matchup with the Cleveland Indians, the Chicago Cubs have a great deal of uncertainty around them.

The pitching staff feels like trying to plug holes in a sinking ship using your fingers, guys you counted on to carry the offense havent showed up and beyond 2020, the financials for the organization will be a huge focus for ownership.

Underperforming stars like Kris Bryant, Anthony Rizzo, Willson Contreras, Kyle Schwarber and Javier Baez arent going anywhere. Why? Because Theo Epstein isnt about to sell low on any of them. It seems far more likely the club hopes for a return to form with eyes cast toward some potential trade deadline deals in 2021.

Chicago is hoping to pull off one more deep postseason run before the group that gained baseball immortality in 2016 begins to go its separate ways. Next years Cubs could look vastly different and for a variety of reasons, these three guys seem highly unlikely to be a part of the 2021 club.

Use your (arrows) to browse

See the article here:
Cubs: 3 players whose futures with team are doomed after shortened season - Cubbies Crib

I’m Thinking Of Ending Things: Who The Caller On The Phone Is – Screen Rant

In I'm Thinking of Ending Things, a young female character receives mysterious phone calls, so who's on the other end? Here's our breakdown.

WARNING: Spoilers for I'm Thinking of Ending Things.

In I'm Thinking of Ending Things, a young female characterreceives mysteriousphone calls, so who's on the other end? The Netflix film initially plays out like a quirky relationship drama, but then evolves into a surrealist character study about love, loss, and regret. Written and directed by the eclectic filmmaker Charlie Kaufman, I'm Thinking of Ending Thingsis based on Iain Reid's 2016 eponymous novel.

Starring Jesse Plemons andJessie Buckley,I'm Thinking of Ending Things' titular concept stems from insecuritiesfaced by a couple during the early stages of their relationship. On a snowy evening, Jake (Plemons) drives girlfriendLucy (Buckley) to his parents' home for a first meeting, only something feels off from the start. Jake can seemingly hear Lucy's inner dialogue, and then behaves oddly when arriving at the country destination; he refuses to enter his formerhome right away, and instead gives Lucy a property tour while explaining the deaths of various sheep and pigs. When the couple finally joins "Mother" (Toni Collette) and "Father" (David Thewlis) for dinner, Lucy comes to realize that Jake most likely had a difficult childhood. But what troubles her the mostare incoming phone callsthat she doesn't respond to.

Related:I'm Thinking Of Ending Things: How The Movie Compares To The Book

Within the first 10 minutes of I'm Thinking of Ending Things, Lucy receives a call from someone named "Lucy."Shortly after, Jake references an early 19th century poem by English writerWilliam Wordsworthentitled "Ode: Intimations of Immortality from Recollections of Early Childhood." Jake then informs his girlfriend Lucy thatWordsworth once wrote a series of poems for a woman named Lucy, whom he describes as a "beautiful, idealized woman who dies young." Later, during the family dinner, Lucy notices that she has several missed calls from "Lucy" and now"Louisa." After the family dinner, she spots a photo that appears to be herself as a child, and theface then changes to a younger version of Jake during a second glance. Seconds later, Lucy receives a phone call from "Yvonne." From this point forward, it's heavily implied in I'm Thinking of Ending Things that Lucy is a figment of Jake's imagination, and that the older janitor (Gus Boyd) - who frequently appears in side sequences -has dreamed up the entire narrative while reflecting about his life. The mysterious calls are messages from the janitor to his subconscious.

The cryptic phone calls in I'm Thinking of Ending Things thematically link tothe opening minutes. During voiceover narration, Lucy states that "It feels like I've known Jake longer than I have." The character stands on a city sidewalkand looks to the sky as snow falls, and then feels drawn to something in the second or third level of a nearby building. The aforementioned janitor looksdown at Lucy and mutters to himself: "The assumptions are right. I can feel my fear growing. Now is the time for the answer. Just one question." Seconds later, Plemons' Jake shows up, and the narrative properly begins, or so it seems. With this early passing moment in I'm Thinking of Ending Things, Kaufman establishes the premise for the cryptic phone calls, evidenced by the fact that the mid-movie voicemail from"Yvonne" includes a line from the opening: "There's only one question to answer."

Here is the original post:
I'm Thinking Of Ending Things: Who The Caller On The Phone Is - Screen Rant