Verizons #Next20: The growing impact and influence of Gen Z – Yahoo Lifestyle

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A new survey that began to circulate on Wednesday, provides a grim picture of how little Americans really know about the Holocaust. The event that has been called the greatest crime of the century has apparently escaped the consciousness of a large swath of the American public specifically young Americans who fall into the Millennial and Gen Z age frames.The survey was conducted by the Conference on Jewish Material Claims Against Germany (Claims Conference) and included 1,000 Millennials and Gen Z-ers between the ages of 18 and 39 from all 50 states. It found that its not just the details that many Americans are unaware of there are plenty who think the Holocaust never happened or who have never even heard the term before.According to their findings, nearly two-thirds of respondents did not know 6 million Jews were killed during the Holocaust, nearly half cannot name a single concentration camp, and 11 percent believe Jews caused the Holocaust, while 12 percent say they havent heard (or dont think theyve heard) the word Holocaust before.The results are both shocking and saddening and they underscore why we must act now while Holocaust survivors are still with us to voice their stories, Gideon Taylor, President of the Claims Conference, said in a statement. Its concerning that a survey conducted in the U.S. suggests that nearly two-thirds of US young adults are unaware that 6 million Jews were murdered during the Holocaust, the Holocaust Memorial Day Trust said on Twitter. This is why Holocaust education and commemoration is so important today.Some states fared better than others: Wisconsin, Minnesota, Massachusetts, Maine, Kansas, Nebraska, Pennsylvania, Idaho, Iowa, and Montana had what the survey called the highest Holocaust Knowledge Scores (calculated using the percentage of respondents who had definitively heard of the event, knew 6 million Jews had died, and could name at least one concentration camp). States that had the lowest scores were Alaska, Delaware, Maryland, New York, Georgia, Hawaii, Louisiana, Florida, Mississippi, and Arkansas.The results are likely due to a combination of a lack of Holocaust education in schools and an increasing number of Holocaust denial and conspiracy theory content online from the alt-right. This reality is dangerous, contributing to the rising antisemitic attitudes the United Staes is currently seeing, as well as an inability to properly contextualize the current warning signs and parallels like the news of the forced sterilizations being performed by ICE or the fact that concentration camps on the border exist at all.Other findings included in the report detailed that almost a quarter of respondents (23%) believed the Holocaust was just a myth, with over half (56%) claiming to have seen Nazi symbols on their social media channels.The Claims Conference said that their mission in conducting this study was to provide a measure of justice for Jewish Holocaust victims, particularly as Holocaust survivors are becoming fewer, and younger generations will have less tangible references.We need to understand why we arent doing better in educating a younger generation about the Holocaust and the lessons of the past, Taylor said. This needs to serve as a wake-up call to us all, and as a road map of where government officials need to act.Like what you see? How about some more R29 goodness, right here?I'm An Orthodox Jew & This Is Why I Wear A WigA Nurse Reveals ICE Is Performing HysterectomiesWhat's Happening In The Migrant Detention Centers

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Verizons #Next20: The growing impact and influence of Gen Z - Yahoo Lifestyle

What ‘O Brother, Where Art Thou?’ Gets Right (and Wrong) About America – PopMatters

The one-eyed dude abides.

Well actually, John Goodman, playing bible salesman Big Dan Teague, doesn't so much abide, as he assails.

Breaking a massive branch right off the tree for use as club, Teague wallops two main protagonists in a scene that has become a hallmark of the Coen brothers' O Brother, Where Art Thou? The scene is film school clip-effective. Teague, only slightly taller than George Clooney's Ulysses Everett McGill, seems to tower over his victims, thanks to careful camera angles. For a moment, Teague seems to embody Polyphemus, Homer's massive mountain of a cyclops, as he robs the two men of their ill-gotten aims.

Yes, the general outline of the Greek epic is there, but there is much more. First, there is the swipe at Bible Belt morality; Teague admits early in the scene that he's only in the scripture trade for the money. Then there's the cartoon-like violenceTom and Jerry skirting the contours of the Classics Illustrated-version of the Odyssey with some allusions to Twain. Finally, there's the sly nod to the amphibian-focused sadism of the Beavis and Butthead characters as first introduced in Mike Judge's 1992 festival short, Frog Baseball.

Unlike in the epic, however, Ulysses Everett and Delmar O'Donnell (Tim Blake Nelson) don't outwit the big galoot. Teague prevails. Telling the tale of the cyclops through the lens of high and low culture, the Coens hammer home a fatalistic criticism about the ways that commerce, violence, and cosmetic Christianity prevail in American society.

John Goodman as Big Dan Teague (IMDB)

October marks the 20th anniversary of US theatrical release of the Coens' first music-focused comedy. Although initial reviews were mixed, O Brother, Where Art Thou? has weathered well, becoming, next to 1998's The Big Lebowski, perhaps the most universally loved of the Coens' films even if critics at the time, such as Roger Ebert, wondered whether the brothers left too many threads incomplete. One can hardly quibble with Ebert. A music-packed satire that stages Homer's Odyssey in the Jim Crow South, created in part to answer the philosophical ponderings of a 1940s screwball comedy? That must have been one hell of a pitch meeting.

These unfinished but occasionally brilliant threads nevertheless are what is most endearing about the film. A perfect film, no. But one that even my 11-year-old son thinks is hilarious and which raises interesting questions about what it means to be a decent human being in the age of the COVID-19 pandemic and Black Lives Matter demonstrations against police violence, yes.

My interest in the film's flaws and strengths led me to incorporate O Brother into a college topics class that I periodically teach about the culture, music, and political history of the South during the first half of the 20th century.

The decision to center the class around the film didn't come easily. The first time we watched it, I worried that the larger-than-life storytelling stylea facet early reviewers derided as fluffmight present a false view of a region already subject to too much caricature. But as the students and I dug deeper, we realized that dissecting the film led us to greater insights about the untruths surrounding some of the myths about the South as well as the legacy and the origins of actual Southern mythologies such as Stagger Lee and John Henry. We also concluded that key institutions depicted in the film such as the racist Solid South political system and the notable offspring of that system, such as Huey Long and Memphis Boss Edward "Red Snapper" Crump were indeed deserving of the caricature.

The most obvious byproduct of the film is a mini-folk revival that encourages Americans to revisit the blues and reclaim overlooked genres such as bluegrass. Listeners today may still be navigating the half-life of this resurgence in the lingering radio yawp of Caamp, the Lumineers, Mumford & Sons, and their imitators.

But beyond reviving interest in musical Americana, the film gets many things right about the American South. At first glance, the politicians in O Brother appear to be cartoonish, attention-seeking buffoons who seem to have no parallel in postwar American history. I mean, putting yourself back in the year 2000, could you imagine Bob Dole or Al Gore acting like that?

Now, in these times of the Trump administration, we understand that cartoonish buffoons not only capture attention but get elected to the highest offices in the land. From a historical standpoint, we now know that large segments of the country have been electing cads for some time, many of whom, like governors Pappy O'Daniel in Texas (memorably depicted by Charles Dunning in the film), Jimmie Davis in Louisiana, Big Jim Folsom in Alabama, and Fiddlin' Bob Taylor in Tennessee, actually performed country music to get elected.

(IMDB)

These figures, so deftly satirized in O Brother, were pioneers in combining celebrity, entertainment, and political ambitions generations before Ronald Reagan, Trump, and Arnold Schwarzenegger, as I relate in my recent book I'd Fight the World: A Political History of Old Time, Hillbilly, and Country Music. Like villain Homer Stokes (Wayne Duvall) in the film, Big Jim even hauled out a bucket and mop pledging to "clean out the capitol", some 68 years before Trump and his promises about draining the Washington, D.C. "swamp".

Then there's the Greek mythology thing. The Coens must have been divining the fustiest crannies of Southern gentility when writing thatfor upper-class white Southerners in the late 19th and early 20th century were simply gaga for the Classics. We all know of the Doric columns on Gone with the Wind's Terra, but four Southern cities and college towns were vying to be "Athens of the South" while builders were erecting Greek-influenced Plantation Revival architecture faster than Huey Long could skim the Louisiana state coffers. Nashville even erected a full-scale replica of the Parthenon, complete with an intact 40 foot tall statue of the goddess Athena!

You see, when the planters of the Old South met up with the industrialists of the New, Ancient Greece was appealing: a mythically democratic yet decidedly nonegalitarian slave-owning society. The Confederate monuments that protestors are toppling today are often drawn from the same font of Greco-Roman influences, especially in their depictions of women as goddesses and allegorical figures.

O Brother falls down a bit when it comes to actual depictions of Black people. Critics such as Matthew W. Hughey have attacked the film for offering abbreviated and uni-dimensional portraits of its few notable Black characters: bluesman Tommy Johnson and an unnamed blind seer. The Johnson character, an on-again-off-again comrade of the three white heroes played by talented musician Chris Thomas King, is a mashup of the real-life blues performers Tommy Johnson and Robert Johnson, whose supposed deal with the devil O Brother touts uncritically. The blind prophet (Lee Weaver), on the other hand, can be read as a simple spinoff of the "Magical Negro", that silver screen stereotype whose race appears to give him affinity with strange or spiritual forces.

Chris Thomas King as Tommy Johnson (IMDB)

I reached out to Grammy-winning artist Rhiannon Giddens on this question, wondering what a working musician who has done a lot to educate the public on the African American sources of country, bluegrass, and traditional music thought about the depictions in the film. Giddens said that while the music of O Brother had a "huge impact" on her, she too feels circumspect about the way Black music and culture was portrayed in the film. "Unfortunately the portrayal of black music followed the same old tropes," she says, "but they are very strong tropes that have been forced upon the American narrative and we are only just beginning to challenge and dismantle them in a significant way."

My students weren't especially upset at these depictions and the way they contributed to the softly anti-racist arc of the film. They didn't expect much more from Hollywood, but they also wished there was more screen time for Black characters and more attention to the storylines connected to Black music history. Several told me they appreciated the way the film introduced them, as hip-hop fans, to music their grandparents performed or were partial too. Many were excited about the way our class challenged them to make connections between contemporary releases and older forms of the blues and gospel.

The film's depictions of women are likewise somewhat weak. Penny, played by Holly Hunter and loosely based on Homer's Penelope, makes a few appearances and exerts a smidgeon of agency over her life, but her personal choices are erratic and barely rise above the stereotype offered in the original epic.

Perhaps next to the cyclops affair, one of the more memorable scenes involves three backwoods Sirens, expertly voiced but not portrayed by Emmylou Harris, Alison Krauss, and Gillian Welch. Bathing in a river, the three Sirens lull Ulysses, Delmar, and Pete to sleep with their highly sexualized version of "Didn't Leave Nobody But the Baby". One of the students in my class noticed in her paper that the song, a slave lullaby often titled "Go to Sleep Little Baby," stemmed way back in Black southern folk culture. She was particularly struck by Bessie Jones's version and her explanation about how it reflects a precious, perhaps stolen, moment between a Black mother and child. That something so personal is used commercially to support the most sexualized scene in the movie just didn't sit so well, when the class talked about it.

Christy Taylor, Musetta Vander, Mia Tate as the Sirens [ Touchstone Pictures / Universal Pictures - All Rights Reserved / (IMDB)]

There are, of course, other threads that the film gets right. The critique of the carceral state and police brutality, though brief, is compelling. I noticed when preparing for the class that the prominently-placed Dapper Dap pomade probably draws from a real-life cosmetic, Sweet Georgia Brown pomade, marketed by the Valmor Products Co. to African Americans in the early to mid-20th century. Ulysses Everett's devotion to this product and his use of a hair net, as my students observe, gives new dimension to the accusations made by the cinematic villain Homer Stokes that the three heroes are of "miscegenated" origins.

Other subthemes age surprisingly well: the satire, for instance, aimed at the zany Oz-like Klansmen who march in strange formations and could probably O-wee-o their own with the best of today's cowardly groypers and armchair alt-right trolls. The unsettling aspect is the renewed visibility of such miscreants, whether spreading antisemitic conspiracies on social media or carrying Tiki torches, as they did in Charlottesville, Virginia, in August 2017.

(IMDB)

Political writer and podcaster Mark Hemingway similarly has pointed out that the film makes profound distinctions between thoughtful, authentic Christianity and the superficial Lotus Eater-like faith of those mesmerized by "Down to the River to Pray".

But of course, there are threads that run afoul. The size-ism of the Stokes rally seems frankly just plain embarrassing today.

Not everything holds up in this film's critique of the American South. Not everything passes the test of time. But it still touches us in deep and important ways, making us think about how myth, history, and cultural inheritances filter into the present, and about what elements of myth and history we choose to hold onto.

It's important to remember that when the Coens released O Brother on the heels of the 1999 Seattle World Trade Organization protests, they were partially trying to answer director Preston Sturges's query about the meanings of art in Sullivan's Travels (1941), the movie from which O Brother inherits its title. Sturges poses the question of whether challenging audiences to respond politically to stark realities is more effective in making the world a better place than simply making audiences laugh.

The Coens' rejoinder, it seems, is that comedy can make life more enjoyable and provoke thoughtful conversations about the associations between history and injusticejust as long as the storyline is immersed in old-timey music magic and a digitally-corrected yellow-sepia tone. Given the COVID-19 quarantine and the seemingly never-ending onslaught of bad news these days, perhaps blending a little joyful nostalgia with an appeal to thought and action is not the worst combination one can imagine.

Perhaps O Brother's appeal lies in these compelling but unfinished threads, which surprise us and make us hunger to learn more. Or perhaps we enjoy the film because we are a broken society, still waiting to be perfected and finished like the film itself. As Clooney in his role as Ulysses notes: "it's a fool that looks for logic in the chambers of the human heart."

(IMDB)

* * *

Works Cited

Alpine, Mary Kate. "The Complicated Politics of O Brother, Where Art Thou?". Medium.com. 8 November 2017.

Clayman, Andrew. "Valmor Products Co., est. 1926". Made in Chicago Museum. n.d.

Filene, Benjamin. "O Brother, What Next?: Making Sense of the Folk Fad". Southern Cultures 10, No. 2 (summer 2004).

Ebert, Roger. Review of O Brother, Where Art Thou? RogerEbert.com. 29 December 2000.

Hughey, Matthew W. "Cinethetic Racism: White Redemption and Black Stereotypes in 'Magical Negro' Films". Social Problems 56, no. 3 (August 2009).

La Chapelle, Peter. I'd Fight the World: A Political History of Old-Time, Hillbilly, and Country Music. University of Chicago Press. University of Chicago Press, 2019.

Orr, Christopher. "30 Years of Coens: O Brother, Where Art Thou?"The Atlantic. 17 September 2014.

Rooney, Kathleen. "'Why Do You Feel Comfortable': On Morgan Parker's 'Magical Negro'". LA Review of Books. 25 February 2019.

Senior, Rebecca. "The Confederate Statues That Have Been Overlooked: Anonymous Women". Washington Post, 10 July 2020.

Siegel, Janice. "The Coens' O Brother, Where Art Thou? and Homer's Odyssey". Mouseion: Journal of the Classical Association of Canada 7, no. 3 (2007)

Stone, Peter, and Ellen Harold. "Bessie Jones." Association for Cultural Equity. n.d.

Walker, Jesse. "Before Trump, There Was Pappy". Reason.com, 25 February 2016.

Winterer, Caroline. The Culture of Classicism: Ancient Greece and Rome in American Intellectual Life, 1780-1910. Johns Hopkins University Press, 2004.

Winterer, Caroline. The Mirror of Antiquity: American Women and the Classical Tradition, 17501900. Cornell University Press, 2009.

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What 'O Brother, Where Art Thou?' Gets Right (and Wrong) About America - PopMatters

Three Things Hulu’s Bay Area-Inspired ‘Woke’ Gets Right and Three Things It Doesn’t – SFist

Lets first address the off-putting elephant in the room: Woke is a terrible name for any television or internet show especially right now. Nevertheless, here we are, reviewing Hulus confusingly-received Woke, which depicts a fictionalized (and modernized) version of the life and career of beloved local cartoonist Keith Knight through the various stunts he pulled in the 90s and 00s.

The show tries to center on timely topics and narratives through all those dated anecdotes but as weve discovered, it isnt usually successful. Over the course of its first season, Woke starring New Girls Lamorne Morris as Keef, an illustrator based on Knight (who also co-created the series), Blake Anderson of Workaholics as his roommate Gunther, SNLs Sasheer Zamata as local alt-weekly reporter Ayana, and more clumsily stumbles far more than it confidently strides.

TL;DR: Woke is a mildly fun, surface-level watch that lacks the nuance it needs to fill an opening in all of our already hectic binging schedules.

Heres a rundown of three things Woke sort of gets right and three things it absolutely does not.

Of the shortlist of concrete goals Wokes first season manages to accomplish, one is its portrayal of the PTSD, crippling anxiety, and another manner of mental health woes that accompany trauma. After being accosted by an all-white police group in a very public manner while flyering Keefs uneasy subconscious starts to express itself outwardly in everyday inanimate objects trash cans, 40-ounce malt liquor bottles, and, most notably, a marker. His struggles also highlight the larger narrative of the mental health plights many actually face when becoming woke, themselves. Amid a long list of missteps, this is one of the few through-lines the streaming series manages to unquestionably land.

Aside from a lack of face coverings, its odiously clear that Woke was a pre-pandemic, pre-George Floyd dive into the murky waters of racial inequalities weve seen in 2020. The controversial topics the series addresses couldnt feel less nuanced or timely; they all seem to lack the certain urgency and rage millions of Americans now feel as Black men and women continue to die en masse. Though the plunges into Black America appear suitable, yes they seem to exist in a greater, more removed narrative than the one were currently all confronted with on a daily basis. However, should the series be renewed for a second season, it would be interesting to see how the show chooses to look more inwardly at the murders of George Floyd and Breonna Taylor at the hands of police officers, as well as the recent shooting of Jacob Blake.

Its almost hard not to cringe at Gunthers overtly West Coast liberal hipness and you cant help but feel thats exactly how Knight wants you to endure watching him go about his life. The entire eight episodes ebb and flow on a sort of newfound hipster convergence for the controversial cartoonist, too. And in that meeting, no quote lefty topic is off-limits to tackle: police brutality, white liberal racism, cancel culture, queerness and gender conformity, Black creative integrity (and appropriation), and, of course, mental health.

Watching Woke, youre enveloped in the Bay Area and SFs historically bohemian qualities and creative twangs around every plot turn. But whats sorely lacking is an honest, not-so-pretty portrayal of the many financial struggles hundreds of thousands face across the Bay Area, all of which have been exacerbated by the pandemic. (Again, the show was written and shot a while ago.) A passive watch through the series leaves you understanding that "its expensive" to live in the region, but otherwise viewers are merely presented with digestible, sliding-screen-door glimpses into the homelessness problem, rather than ever tackling it in its complexity. But I guess it's a comedy, so...

Even just two episodes in, you (as a viewer) are immediately reminded about the prankster, pot-stirring genius that is the IRL Keith Knight. The show thoroughly highlights his sharp wit and antics like, for example, posting flyers around SF for a bogus service that would allow customers to rent Black people. The show also relays the well-documented and wide-ranging reactions his flyers received, allowing for some space to have uncomfortable conversations with those you may be watching with. Moreover, when Woke manages to pepper in those kinds of moments, it provides some much-needed seasoning for an otherwise bland viewing experience.

Wokes most egregious disappointment isnt in its blind-eyeing of certain topics or its bouts of hollow humor, but rather in how the scripts are clearly manifested under the idea of white palatability. Every detail the cadences, the cinematography, the depictions of Black America of the show come across as diluted... as if Hulus executive board (which doesnt include a single Black individual) was afraid the intended final product would be too Black for a broader audience to get behind. Alas, were left with flashes of authenticity that merely get overshadowed by an umbrella of lukewarm convictions.

And that, reader, is the opposite of being "woke."

Related: Bay Area-Based 'Dilbert' Cartoonist Scott Adams Sparks Outrage For Using Gilroy Shooting To Promote His App

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Forty thousand moments of mourning | Art | santafenewmexican.com – Santa Fe New Mexican

Technically, a spreadsheet that lists migrants and refugees who have died while trying to get into Europe isnt art. The efficiently ordered data isnt beautiful to look at or otherwise aesthetically pleasing. Its a brutal mix of briefly described violence and incomplete sentences. Names and ages, if theyre known, go in one column; countries of origin go in another. The most detailed column reveals the ways in which the migrants died.

Some drowned in the Mediterranean Sea. Some were crushed trying to get from raft to land. Some killed themselves after their applications for asylum were denied.

Every year since 1993, the European NGO network UNITED for Intercultural Action has maintained and updated what is known as the List of Deaths as a way to monitor the human cost of Europes strict immigration policies. The list is free to download at unitedagainstracism.org, and as of June 19, the PDF document contains information about the deaths of 40,555 people at European borders. Turkish artist Banu Cennetolustumbled upon the list in 2002 and decided it needed to be seen by as many people as possible. Because of her efforts and those of other like-minded artists and curators around the world, the list has been displayed, in a variety of formats, in Athens, Barcelona, Berlin, and Los Angeles, among other locales, since 2006.

SITE Santa Fe features The List of Deaths printed on 16 pages of standard 8.5 x 11-inch paper and displayed behind Plexiglass on a 20-foot-long wall.

A detail from The List of Deaths PDF, which can be downloaded and printed at unitedagainstracism.org

SITE Santa Fes assistant curator, Brandee Caoba, co-curated Displaced with Irene Hofmann, SITEs Phillips director and chief curator. Caoba points out that when the media reports on war and the accompanying immigration crises, confusing or impersonal language can render death into nothing but a numbers game. If a soldier loses their life, theyre called a troop instead of by their name, and a troop sounds like more than one person, she says. If you say that 40 people lost their lives this week crossing the Mediterranean, it doesnt have the same gravity as [knowing] where they were going, where they were coming from, and why they left.

The list offers this information in a way that feels akin to found poetry. Grim as they are, the causes of death have flow and pacing; they have repeated imagery. Body found in river. Found dead in sea. Hit by car. Hit by car. Found dead on boat. Even when the dead cannot be identified by their names, the list allows for a moment to reflect on them as individuals.

At first, Cennetoluhanded printed lists for friends and strangers. She left copies in cafs, and even put stickers referencing the list on ATMs. But she wanted a larger format, such as a billboard, to display it on. She couldnt afford it by herself. Because shes an artist, she concentrated on funding sources in that arena, even though she didnt actually consider the list to be an artwork. For five years, every potential funder shared that perspective and didnt support the project.

According to a June 2018 article in The Guardian by Charlotte Higgins, funding from an unnamed American organization allowed Cennetoluto publish sections of the list on 150 poster sites and hold associated events at the Stedelijk Museum in Amsterdam in 2007. Since then, the list has appeared in newspapers, as posters in train stations, and in other public settings. In the summer of 2018, it was posted on large hoardings (roadside boards for public advertisements) in Liverpool, as part of the citys art biennial. Vandals ripped it down twice. Higgins lamented the crime in the pages of The Guardian that August.

It is hard to imagine the failure of compassion that would impel any individual or group to do this, especially as the list is so modest: it asks nothing of passersby other than that it should be seen. But then, we are living in dangerously fraught times. The arts, in their broadest sense, can no longer be regarded as a dull backwater some distance away from the real business of politics. Culture is the new front line. Those within the alt-right are training their big guns on fresh targets: liberal Hollywood; the press; that defensively constructed catch-all, political correctness.

Caoba invites visitors to take their time with the list in a quiet setting that theyve created. She says its an opportunity to connect with a massive amount of difficult information using the old-fashioned medium of paper, rather than scrolling through it on a screen.

Reading something digitally, youre just glancing. With paper, you have to stop and turn the page.

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Forty thousand moments of mourning | Art | santafenewmexican.com - Santa Fe New Mexican

Breaking: Alyse Galvin sues Division of Elections over transparency ballot – Must Read Alaska

Candidate for U.S. Alyse Galvin has filed a lawsuit against the Division of Elections because, although she sought the nomination of the Democratic Party, she wants the Division of Elections to tell voters that she is an independent on the General Election ballots.

The Division has decided that those independents who run on the Democrat primary ballot will be labeled as yes winners of the Democrat primary.

Galvin has not been completely authentic with Alaskans. She has run against Congressman Don Young with the blessing and endorsement of the Democratic Party, and with Democrat resources, donors, and tools, such as ActBlue.

Now she is trying to run away from the party and has filed a lawsuit to force the Division of Elections to sanction her shapeshifting candidacy.

More details as they become available. Related story below.

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Emily Leproust, Ph.D., to Receive 2020 Rosalind Franklin Award – Business Wire

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Twist Bioscience (Nasdaq: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, today announced that its CEO and co-founder, Emily M. Leproust, Ph.D., will receive the 2020 Rosalind Franklin Award for Leadership at the Biotechnology Innovation Organization (BIO) IMPACT conference. The award will be presented on Tuesday, September 22, 2020 during a virtual fireside chat with Julianna Lemieux of Genetic Engineering News and the Rosalind Franklin Society.

It is a great honor to receive the BIO Rosalind Franklin Award, particularly in 2020, the year she would have turned 100, said Dr. Leproust. At Twist, we stand on the shoulders of giants like DNA pioneer Rosalind Franklin, advancing DNA-based products to write the future of chemical, medical, food and even data storage. We continue to push the boundaries of what is possible, disrupting markets to improve health and sustainability through precisely written DNA.

Emily Leproust is a driven, authentic and thoughtful leader, disrupting the synthetic biology marketplace; she actively works with industry and government leaders to drive innovation and further the bioeconomy, commented Stephanie Batchelor, vice president of BIOs industrial and environmental section. Twists focus on the power of synthetic DNA to revolutionize multiple markets directly reflects the spirit of the Rosalind Franklin Society and Award.

About the BIO Rosalind Franklin Award

Just as Rosalind Franklin paved the way for women in the biotechnology field, the BIO Rosalind Franklin Award is presented to a pioneering woman in the industrial biotechnology and agriculture sectors who has made significant contributions to the advancement of the biobased economy and biotech innovation. The Rosalind Franklin Award will stand as a lasting memory to the legacy left by Rosalind Franklin, who was instrumental in the discovery and our greater understanding of the molecular structure of DNA, by honoring those women who too have made significant contributions in industrial biotechnology and agriculture. With this award BIO honors Rosalind Franklins legacy, but also those women who have shown exemplary leadership and led the way through previously uncharted territory. The Award is sponsored by the Rosalind Franklin Society, whose goal is to support and showcase the careers of eminent women in science.

Rosalind Franklin conceived and captured Photograph 51 of the "B" form of DNA in 1952, while at King's College in London. This photograph, acquired through 100 hours of X-ray exposure from a machine Dr. Franklin herself refined, revealed the structure of DNA. The discovery of the structure of DNA was the single most important advance of modern biology. James Watson and Francis Crick, working at Cambridge University, used Photograph 51 as the basis for their famous model of DNA, which earned them a Nobel Prize in 1962. Though sometimes overlooked, Rosalind Franklins critical work and discovery in the field has allowed the biotechnology industry to become what it is today.

About Twist Bioscience Corporation

Twist Bioscience is a leading and rapidly growing synthetic biology company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by writing DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.

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Legal Notice Regarding Forward-Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical facts contained herein are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve known and unknown risks, uncertainties, and other important factors that may cause Twist Biosciences actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the risks and uncertainties of the ability to attract new customers and retain and grow sales from existing customers; risks and uncertainties of rapidly changing technologies and extensive competition in synthetic biology could make the products Twist Bioscience is developing obsolete or non-competitive; uncertainties of the retention of a significant customer; risks of third party claims alleging infringement of patents and proprietary rights or seeking to invalidate Twist Biosciences patents or proprietary rights; and the risk that Twist Biosciences proprietary rights may be insufficient to protect its technologies. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Twist Biosciences business in general, see Twist Biosciences risk factors set forth in Twist Biosciences Quarterly Report on Form 10-Q dated August 12, 2020. Any forward-looking statements contained in this press release speak only as of the date hereof, and Twist Bioscience specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

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Genome Editing/Genome Engineering Market Research Report by Technology, by Application – Global Forecast to 2025 – Cumulative Impact of COVID-19 -…

New York, Sept. 18, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Genome Editing/Genome Engineering Market Research Report by Technology, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05953106/?utm_source=GNW

The Global Genome Editing/Genome Engineering Market is expected to grow from USD 4,901.67 Million in 2019 to USD 14,012.67 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 19.13%.

Market Segmentation & Coverage:This research report categorizes the Genome Editing/Genome Engineering to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Technology, the Genome Editing/Genome Engineering Market studied across Antisense, Crispr, Talen, and Zfn.

Based on Application, the Genome Editing/Genome Engineering Market studied across Cell Line Engineering, Diagnostic Applications, Drug Discovery & Development, and Genetic Engineering. The Genetic Engineering further studied across Animal Genetic Engineering and Plant Genetic Engineering.

Based on Geography, the Genome Editing/Genome Engineering Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles:The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Genome Editing/Genome Engineering Market including Creative Biogene, Crispr Therapeutics, Editas Medicine, Epigenie, Eurofins Scientific SE, Genscript Biotech, Horizon Discovery Group PLC, Integrated DNA Technologies, Inc., Intellia Therapeutics, Inc., Lonza Group AG, Merck & Co., Inc., New England Biolabs, OriGene Technologies, Inc., Oxford Genetics Ltd., Precision Biosciences, Sangamo Therapeutics, Synthego Corporation, Thermo Fisher Scientific Inc., Transposagen Biopharmaceuticals, Inc., and Vigene Bioscience Inc..

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Genome Editing/Genome Engineering Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as:1. What is the market size and forecast of the Global Genome Editing/Genome Engineering Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Genome Editing/Genome Engineering Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Genome Editing/Genome Engineering Market?4. What is the competitive strategic window for opportunities in the Global Genome Editing/Genome Engineering Market?5. What are the technology trends and regulatory frameworks in the Global Genome Editing/Genome Engineering Market?6. What are the modes and strategic moves considered suitable for entering the Global Genome Editing/Genome Engineering Market?Read the full report: https://www.reportlinker.com/p05953106/?utm_source=GNW

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New molecular therapeutics center established at MIT’s McGovern Institute – MIT News

More than 1 million Americans are diagnosed with a chronic brain disorder each year, yet effective treatments for most complex brain disorders are inadequate or even nonexistent.

A major new research effort at the McGovern Institute for Brain Research at MIT aims to change how we treat brain disorders by developing innovative molecular tools that precisely target dysfunctional genetic, molecular, and circuit pathways.

The K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience was established at MIT through a $28 million gift from philanthropist Lisa Yang and MIT alumnus Hock Tan 75. Yang is a former investment banker who has devoted much of her time to advocacy for individuals with disabilities and autism spectrum disorders. Tan is president and CEO of Broadcom, a global technology infrastructure company.This latest gift brings Yang and Tans total philanthropy to MIT to more than $72 million.

In the best MIT spirit, Lisa and Hock have always focused their generosity on insights that lead to real impact," says MIT President L. Rafael Reif. Scientifically, we stand at a moment when the tools and insights to make progress against major brain disorders are finally within reach. By accelerating the development of promising treatments, the new center opens the door to a hopeful new future for all those who suffer from these disorders and those who love them. I am deeply grateful to Lisa and Hock for making MIT the home of this pivotal research.

Engineering with precision

Research at the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience will initially focus on three major lines of investigation: genetic engineering using CRISPR tools, delivery of genetic and molecular cargo across the blood-brain barrier, and the translation of basic research into the clinical setting. The center will serve as a hub for researchers with backgrounds ranging from biological engineering and genetics to computer science and medicine.

Developing the next generation of molecular therapeutics demands collaboration among researchers with diverse backgrounds, says Robert Desimone, McGovern Institute director and the Doris and Don Berkey Professor of Neuroscience at MIT. I am confident that the multidisciplinary expertise convened by this center will revolutionize how we improve our health and fight disease in the coming decade. Although our initial focus will be on the brain and its relationship to the body, many of the new therapies could have other health applications.

There are an estimated 19,000 to 22,000 genes in the human genome and a third of those genes are active in the brain the highest proportion of genes expressed in any part of the body. Variations in genetic code have been linked to many complex brain disorders, including depression and Parkinsons disease. Emerging genetic technologies, such as the CRISPR gene editing platform pioneered by McGovern Investigator Feng Zhang, hold great potential in both targeting and fixing these errant genes. But the safe and effective delivery of this genetic cargo to the brain remains a challenge.

Researchers within the new Yang-Tan Center will improve and fine-tune CRISPR gene therapies and develop innovative ways of delivering gene therapy cargo into the brain and other organs. In addition, the center will leverage newly developed single-cell analysis technologies that are revealing cellular targets for modulating brain functions with unprecedented precision, opening the door for noninvasive neuromodulation as well as the development of medicines. The center will also focus on developing novel engineering approaches to delivering small molecules and proteins from the bloodstream into the brain. Desimone will direct the center and some of the initial research initiatives will be led by associate professor of materials science and engineering Polina Anikeeva; Ed Boyden, the Y. Eva Tan Professor in Neurotechnology at MIT; Guoping Feng, the James W. (1963) and Patricia T. Poitras Professor of Brain and Cognitive Sciences at MIT; and Feng Zhang, James and Patricia Poitras Professor of Neuroscience at MIT.

Building a research hub

My goal in creating this center is to cement the Cambridge and Boston region as the global epicenter of next-generation therapeutics research. The novel ideas I have seen undertaken at MITs McGovern Institute and Broad Institute of MIT and Harvard leave no doubt in my mind that major therapeutic breakthroughs for mental illness, neurodegenerative disease, autism, and epilepsy are just around the corner, says Yang.

Center funding will also be earmarked to create the Y. Eva Tan Fellows program, named for Tan and Yangs daughter Eva, which will support fellowships for young neuroscientists and engineers eager to design revolutionary treatments for human diseases.

We want to build a strong pipeline for tomorrows scientists and neuroengineers, explains Hock Tan. We depend on the next generation of bright young minds to help improve the lives of people suffering from chronic illnesses, and I can think of no better place to provide the very best education and training than MIT.

The molecular therapeutics center is the second research center established by Yang and Tan at MIT. In 2017, they launched the Hock E. Tan and K. Lisa Yang Center for Autism Research, and, two years later, they created a sister center at Harvard Medical School, with the unique strengths of each institution converging toward a shared goal: understanding the basic biology of autism and how genetic and environmental influences converge to give rise to the condition, then translating those insights into novel treatment approaches.

All tools developed at the molecular therapeutics center will be shared globally with academic and clinical researchers with the goal of bringing one or more novel molecular tools to human clinical trials by 2025.

We are hopeful that our centers, located in the heart of the Cambridge-Boston biotech ecosystem, will spur further innovation and fuel critical new insights to our understanding of health and disease, says Yang.

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New molecular therapeutics center established at MIT's McGovern Institute - MIT News

Recreational pot wins nod in Downtown Crossing and across the city – Universal Hub

The Boston Cannabis Board yesterday approved a proposal by the city's first medicinal-marijuana dispensary, on Milk Street, to add recreational pot to its offerings and approved a number of proposed pot shops from East Boston to Roslindale.

The votes by the board do not mean the shops can now open - they still need to win approval from the Massachusetts Cannabis Control Commission, which can prove a lengthy process.

However, Patriot Care, which won city approval for its medical dispensary at 21 Milk St. after promising it would not seek to add "adult use" products, will get an expedited review for its shop because it already has approval to sell medical marijuana.

In its vote yesterday, the city board set several conditions on its approval, including that the new shop sell recreational pot only on an appointment basis for its first six months and that it would have to return to that model if, starting in the seventh month, lines start forming outside. Also, the shop can't sell "pre-rolled cannabis products," has to set a minimum order of $35, and has to include educational information about marijuana in each products.

Also yesterday, the board approved:

The board rejected a proposal by Dragon Vapors, LLC for a pot shop at 354-358 Chestnut Hill Ave. in Brighton and deferred until October a vote on a proposal by New Dia LLC for a pot shop that would share space in the building housing the Cask and Flagon across from Fenway Park.

The board approved a proposal by Beacon Compassion, Inc. for a medical dispensary at 1524 VFW Parkway in West Roxbury - it would go in the basement of the building that already houses a liquor store and a sex-toys shop.

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Recreational pot wins nod in Downtown Crossing and across the city - Universal Hub

Poseida Therapeutics Added to Membership of US Small-Cap Russell 2000 Index – Monterey County Weekly

SAN DIEGO, Sept. 18, 2020 /PRNewswire/ --Poseida Therapeutics, Inc., (Nasdaq: PSTX), a clinical-stage biopharmaceutical company dedicated to utilizing its proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure, today announced its addition as a member of the US small-cap Russell 2000Index, effective September 18, 2020, as part of the index's quarterly initial public offering (IPO) additions.

"We are pleased to be added to the US small-cap Russell 2000 Index, which will help increase investor exposure to our Company's mission of providing cell and gene therapies for patients with high unmet medical need," said Eric Ostertag, M.D., Ph.D., Chief Executive Officer ofPoseida. "We look forward to the opportunity to expand awareness around our pipeline of differentiated product candidates for the treatment of a variety of oncology indications and orphan genetic diseases."

Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $9 trillion in assets are benchmarked against Russell's US indexes. Russell indexes are part of FTSE Russell, a leading global index provider.

For more information on the Russell 2000 Index and the Russell indexes IPO additions, please visit the "Russell U.S. Index IPO Additions" section on the FTSE Russell website.

About Poseida Therapeutics, Inc.Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBacDNA Modification System, Cas-CLOVER site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

About FTSE RussellFTSE Russell is a leading global index provider creating and managing a wide range of indexes, data and analytic solutions to meet client needs across asset classes, style and strategies. Covering 98% of the investable market, FTSE Russell indexes offer a true picture of global markets, combined with the specialist knowledge gained from developing local benchmarks around the world.

FTSE Russell index expertise and products are used extensively by institutional and retail investors globally. Approximately $16 trillion is currently benchmarked to FTSE Russell indexes. For over 30 years, leading asset owners, asset managers, ETF providers and investment banks have chosen FTSE Russell indexes to benchmark their investment performance and create investment funds, ETFs, structured products and index-based derivatives. FTSE Russell indexes also provide clients with tools for asset allocation, investment strategy analysis and risk management.

A core set of universal principles guides FTSE Russell index design and management: a transparent rules-based methodology is informed by independent committees of leading market participants. FTSE Russell is focused on index innovation and customer partnership applying the highest industry standards and embracing the IOSCO Principles. FTSE Russell is wholly owned by London Stock Exchange Group.

For more information, visit http://www.ftserussell.com

Forward-Looking StatementsStatements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding the impact of Poseida's addition to the US small-cap Russell 2000Index, the potential benefits ofPoseida'stechnology platforms and product candidates andPoseida'splans and strategy with respect to developing its technologies and product candidates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based uponPoseida'scurrent expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described inPoseida'sfilings with theSecurities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made.Poseidaundertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

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Poseida Therapeutics Added to Membership of US Small-Cap Russell 2000 Index - Monterey County Weekly

Illuminating the opaque pathways of depression | MSUToday – MSUToday

Depression is a dark horse.

The disease often goes unnoticed, but affects work performance, social interaction and the ability to take pleasure in everyday life. According to theNational Center for Biotechnology Information, antidepressants only help around 50 percent of those who struggle with depression and anxiety and, even when they are effective, scientists have yet to understand how they work in the brain.

MSU associate professor of physiology A.J. Robison and his lab used new CRISPR-based technology to uncover pathways of depression-like behavior in the mouse brain. Credit: College of Natural Science

But groundbreaking research in the lab of Michigan State University scientistA.J. Robison, associate professor in theDepartment of Physiologyand MSUsNeuroscience Program, is directing some new rays of light onto the molecular, cellular and circuit-level mechanisms underlying depression-like diseases.

Theresultswere recently published inNature Communications.

In this paper, we perform the first ever CRISPR-based gene editing [a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified] in a single circuit between two areas of the mouse brain, explained Robison about the culmination of five years of research funded by the National Institutes of Mental Health. We can reach into the mouse brain and manipulate specific genes in a circuit involved in depression and anxiety-like behaviors a critical advance on the road to genetic medicine for psychiatric diseases.

Scientists estimate there are roughly 80-100 billion neurons connecting regions of the brain. To accomplish the feat of locating and manipulating a single gene in a single circuit required new and sophisticated technology. With the expertise of co-author Rachael Neve, director of theGene Transfer Core at Massachusetts General Hospital, they developed it.

The key advance is that we designed a dual-vector system to manipulate a specific gene in the connections between two brain areas, and that has never been done before, Robison said.

Cross section of a mouse brain. The projections of the cells between the vHPC and NAc, shown here in neon green, are manipulated by the new CRISPR viral vector-based technology developed by Rachael Neve and the Robison Lab. Credit: Andrew Eagle

The neurons that Robison and his team zeroed in on originate in the ventral hippocampus (vHPC), a deep-seated structure that projects to regions in the brain important in stress susceptibility, mood and social avoidance. Neurons rooted in the vHPC reach out with branch-like structures called axons to connect with the nucleus accumbens, or NAc. The completed circuit is regulated by the star of the pioneering paper, the transcription factor known as DFosB.

Using the viral vector technology specifically designed and packaged by Neve, the team split the CRISPR system in half. Half of the system, inert on its own, was an enzyme that can mutate DNA in the vHPC. The other half, a guide RNA, was sent to all cells that project to the NAc and tells the enzyme where to bind and the specific gene to mutate. Only those cells specific to the circuit from the vHPC to the NAc got both halves, triggering the enzyme to bind with and turn off a single gene: FosB.

When the FosB gene was turned off in the neurons, we were able to get a circuit-specific behavioral effect relevant to a disease like depression, said Robison about the landmark discovery. When we put it back, or rescued it within the circuit, the effect was erased.

Claire Manning was a key contributor to the groundbreaking study and is now a postdoctoral researcher at Stanford University. Credit: Ken Moon

One of the most exciting findings from our investigations was the circuit-specific role of the FosB protein in conferring resilience to stress, Eagle said. We also discovered that FosB altered the excitability of hippocampal circuit neurons and may be affecting long-term downstream changes that lead to changes in the activity of this circuit. But removing DFosB permanently altered the expression of a suite of genes, in effect removing the conductor from the orchestra. To that end, the paper goes on to report in-depth experiments on DFosB largely done by the members of theRobison Labincluding co-first authorsClaire Manning, a 2019 neuroscience graduate, now a postdoc at Stanford University; andAndrew Eagle, a former postdoctoral researcher, now an assistant professor in the MSU Department of Physiology.

Andrew Eagle, shown here imaging a mouse brain, played a major role in conducting experiments to further probe the function of DFosB. Credit: Research@MSU.

Based on the findings in the paper, the Robison Lab will continue to develop highly collaborative and cutting-edge techniques, accelerated by MSUs newly completed Interdisciplinary Science and Technology Building. This work is important because it elucidates a potential mechanism, namely FosB, for how stress may contribute to depression, Eagle continued. Future clinical work may find ways to directly manipulate FosB, or more likely one of its gene targets, to provide resilience to stress and decrease the incidence of depression in vulnerable people.

The end of this paper, which shows us measuring the changes of expression in hundreds of genes when we remove DFosB, is only the beginning of years of work for our lab, Robison said. Which genes are important and what are they doing in the brain? This is the challenge of a lifetime for me and my lab.

This article is repurposed content originally featured on the College of Natural Sciences website.

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Illuminating the opaque pathways of depression | MSUToday - MSUToday

Muscular Dystrophy Condition in Mice Reversed by RNA-Targeting Cas9 – Genetic Engineering & Biotechnology News

Myotonic dystrophy type I (DM1) is the most common type of adult-onset muscular dystrophy. DM1 is caused by mutations in the DMPK gene. A normal DMPK gene has 3 to 37 repetitions of the CTG sequence, while in DM1, there are hundreds to thousands of repetitions of this sequence. When a DMPK gene with too many CTG repeats is transcribed, the resulting RNA is too long. This abnormally long RNA is toxic to cells, and those affected experience progressive muscle wasting and weakness.

CRISPR-Cas9 is a technique increasingly used in efforts to correct the genetic defects that cause a variety of diseases. Now a research team from the University of California, San Diego (UCSD), School of Medicine, reports they redirected the technique to modify RNA in a method they call RNA-targeting Cas9 (RCas9), to eliminate the toxic RNA and almost fully reverse symptoms in a mouse model of myotonic dystrophy.

Their findings, The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1, was published in Nature Biomedical Engineering and led by Gene Yeo, PhD, professor of cellular and molecular medicine at UCSD School of Medicine.

Myotonic dystrophy is part of a group of inherited disorders called muscular dystrophies. There are two major types of myotonic dystrophy: type 1 and type 2. The muscle weakness associated with type 1 particularly affects muscles farthest from the center of the body, such as those of the lower legs, hands, neck, and face. Muscle weakness in type 2 primarily involves muscles close to the center of the body, such as those of the neck, shoulders, elbows, and hips. The two types of myotonic dystrophy are caused by mutations in different genes.

Many other severe neuromuscular diseases, such as Huntingtons and ALS, are also caused by similar RNA buildup, explained Yeo. There are no cures for these diseases. Yeo led the study with collaborators at Locanabio and the University of Florida.

CRISPR-Cas9 works by directing Cas9 to cut a specific target gene, allowing researchers to inactivate or replace the gene. However, the Cas9 in the RCas9 method is guided to an RNA molecule instead of DNA. In a previous study, Yeo and his team established RCas9 as a means to track RNA in living cells in a programmable manner without genetically encoded tags. In a 2017 study, in lab models and patient-derived cells, the researchers used RCas9 to eliminate 95% of the abnormal RNA linked to myotonic dystrophy type 1 and type 2, one type of ALS and Huntingtons disease.

In the current study, the method goes further, by reversing myotonic dystrophy type 1 in a mouse model of the disease. Toxic RNAs expressed from such repetitive sequences can be eliminated using CRISPR-mediated RNA targeting, yet evidence of its in vivo efficacy and durability is lacking, noted the researchers. Here, using adult and neonatal mouse models of DM1, we show that intramuscular or systemic injections of adeno-associated virus (AAV) vectors encoding nuclease-dead Cas9 and a single-guide RNA targeting CUG repeats results in the expression of the RNA-targeting Cas9 for up to three months, redistribution of the RNA-splicing protein muscleblind-like splicing regulator 1, elimination of foci of toxic RNA, reversal of splicing biomarkers and amelioration of myotonia.

The researchers packaged RCas9 in a non-infectious virus. They then gave the mice a single dose of the therapy or a placebo. RCas9 reduced the abnormal RNA repeats by more than 50%, varying a bit depending on the tissue, and the treated myotonic dystrophy mice became indistinguishable from healthy mice.

To prevent the potential of the RCas9 proteins, developing an immune reaction in the mice, the researchers tried suppressing the mices immune systems briefly during treatment. As a result, they were surprised to see that they successfully prevented immune reaction and clearance. The researchers did not see signs of muscle damage, but found an increase in the activity of genes involved in new muscle formation.

Yeo believes the findings will open a new avenue of understanding and lead the way for treating other genetic diseases. This opens up the floodgates to start testing RNA-targeting CRISPR-Cas9 as a potential approach to treat other human genetic diseasesthere are at least 20 caused by buildup of repetitive RNAs, Yeo added.

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Muscular Dystrophy Condition in Mice Reversed by RNA-Targeting Cas9 - Genetic Engineering & Biotechnology News

Gene Editing Market Trends, Companies, Driver, Segmentation, Forecast to 2024 – The Research Process

Latest updates on Gene Editing market, a comprehensive study enumerating the latest price trends and pivotal drivers rendering a positive impact on the industry landscape. Further, the report is inclusive of the competitive terrain of this vertical in addition to the market share analysis and the contribution of the prominent contenders toward the overall industry.

Rising prevalence of cancer and other genetic disorders coupled with increasing demand for personalized medicine should stimulate gene editing industry expansion. As per WHO 2018 report, cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths. Increasing use of the gene editing tools for treatment of these chronic disorders will favor business growth. Moreover, increased government funding programs will significantly impact industry growth over the forecast timeframe.

Many biopharmaceutical companies are focused on developing innovative drugs for various genetic disorders because of high disease burden across the world and their considerable market potential. Other parameters contributing to the industry growth are increasing demand for synthetic genes, extensive investments in R&D, technological advancements in the field of molecular biology. However, ethical issues regarding misuse of genome editing is a major concern and may hamper the industry growth.

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Gene Editing Market will exceed USD 7.5 billion by 2024; as per a new research report.

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Zinc Finger Nucleases (ZFNs) segment will witness 14.5% CAGR from 2018 to 2024. The segment growth is attributed to increasing adoption of these advanced gene editing tools in research institutes and biotech industries. ZFNs technology offers various advantages including, the mutations made by this technology are permeant and heritable. Zinc finger nucleases are useful to manipulate the genomes of many plants and animals and also has important role in gene editing processes.

Research institutes segment accounted for 30.2% revenue share in 2017 owing to increasing focus on developing innovative therapeutics models in CRISPR and ZFN. Moreover, growing incidences of rare genetic diseases has resulted in high demand for research activities for developing new therapies will propel segmental growth over the coming years.

Animal genetic engineering segment was valued at USD 785.4 million in 2017 and is projected to grow significantly over the forecast timeframe. Growing applications of products obtained from domestic animals has boosted the demand for gene editing technique. In addition, wide applicability of these techniques in animal genetic engineering is also a contributing factor for business growth. For instance, Pigs are susceptible to an infection called Porcine Reproductive and Respiratory Syndrome (PRRS). Gene editing techniques have managed to produce pigs that are resistance to this disease.

U.S. gene editing market will witness 14.5% CAGR by 2024 owing to increasing funding for research and development in genetic editing technologies. As per National Center for Advancing Translational Sciences 2018 report, National Institute of Health (NIH) got $86 million funding for improving genome editing techniques. Moreover, rising prevalence of Alzheimer, cancer and infectious diseases in country. As per Alzheimer?s association 2018 report, an estimated 5.7 million Americans of all ages are living with Alzheimer's. Increasing patient preference towards advanced gene editing tools such as CRISPR/Cas9 for the treatment of Alzheimer's should drive gene editing business expansion.

China gene editing market was valued at USD 154.6 million in 2017 and is estimated to experience considerable growth due to rising R&D expenditure and growing number of industry players. Moreover, various initiatives taken by the Chinese government for promoting life science research in biotechnology sector will stimulate gene editing market growth in forthcoming years.

Major Highlights from Table of contents are listed below for quick lookup into Gene Editing Market report

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Gene Editing Industry Insights

Chapter 4. Company Profiles

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Gene Editing Market Trends, Companies, Driver, Segmentation, Forecast to 2024 - The Research Process

Nanoscale Reflective Coating Reverse-Engineered From Fly Eyes – Technology Networks

The eyes of many insects, including the fruit fly, are covered by a thin and transparent coating made up of tiny protuberances with anti-reflective, anti-adhesive properties. An article published in the journalNaturereveals the secrets of how this nano-coating is made. The authors, from the University of Geneva (UNIGE) and University of Lausanne (UNIL) - together with ETH Zurich (ETHZ) - show that the coating only consists of two ingredients: a protein called retinin and corneal wax. These two components automatically generate the regular network of protuberances by playing the roles of activator and inhibitor, respectively, in a morphogenesis process modelled in the 1950s by Alan Turing. The multi-disciplinary team even succeeded in artificially reproducing the phenomenon by mixing retinin and wax on different kinds of surface. This process, which is very inexpensive and is based on biodegradable materials, was used to obtain nano-coatings with a morphology similar to that of insects, with anti-adhesive and anti-reflective functionalities that could have numerous applications in areas as diverse as contact lenses, medical implants and textiles.

"The nano-coating that covers the surface of the eyes of some insects was discovered in the late 1960s in moths," begins Vladimir Katanaev, a professor in the Department of Cell Physiology and Metabolism in UNIGE's Faculty of Medicine and the study's lead investigator. "It's made up of a dense network of small protrusions about 200 nanometres in diameter and several dozens of nanometres in height. It has the effect of reducing light reflection."

The cornea of an insect without a coating typically reflects about 4% of the incident light, whereas the proportion drops to zero in insects that do have the covering. Although an improvement of 4% may seem small, it is enough of an advantage - especially in dark conditions - to have been selected during evolution. Thanks to its anti-adhesive properties, the coating also provides physical protection against the tiniest dust particles in the air.

Professor Katanaev moved into this research field ten years ago. In 2011, he and his team were the first to discover the nano-coating on the eyes of fruit flies (Drosophila melanogaster). This insect is much more suited to scientific research than moths, in particular because its genome has been completely sequenced.

The Geneva-based researcher has now gathered more evidence to support this hypothesis. Thanks to biochemical analyses and the use of genetic engineering, Professor Katanaev and his colleagues have succeeded in identifying the two components involved in the reaction-diffusion model developed by Turing. This hinges on a protein called retinin and wax produced by several specialised enzymes, two of which have been identified. Retinin plays the role of activator: with its initially unstructured shape, it adopts a globular structure upon contact with the wax and begins to generate the pattern. The wax, on the other hand, plays the role of inhibitor. The powerplay between the two leads to the emergence of the nano-coating.

Initial tests have shown that the coating is resistant to 20 hours of washing in water (it is easily damaged by detergent or scratching, although technological improvements could make it more robust). The anti-reflective properties have already aroused a certain degree of interest among manufacturers of contact lenses, while the anti-adhesive properties could appeal to the producers of medical implants. Indeed, this type of coating could make it possible to control where human cells hook on. Industry already has the techniques needed to obtain this outcome. But they use harsh methods, such as lasers or acids. The Geneva team's solution has the advantage of being inexpensive, benign and totally biodegradable.Reference:

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Nanoscale Reflective Coating Reverse-Engineered From Fly Eyes - Technology Networks

Whats Wrong With the Meritocracy – The New York Times

What, he wonders, if the highly educated harden into a hereditary aristocracy? And what if this occurs under a flag of fairness, during a time when B.A.s and higher degrees are ever more closely tied to income and prestige? Lets set aside the case of rich parents who bribe corrupt officials or donate huge sums to get their child into a good college. Lets focus instead, Sandel writes, on the inequity that creeps in without breaking any rules. At Princeton and Yale, for example, more students come from families in the top 1 percent of income than from the bottom 60 percent. Two-thirds of students in all the Ivy League schools come from families in the top 20 percent. This is very largely because of the head start woven into upper-income life itself: engaging dinner conversation, better schools, private tutors, foreign travel.

Sandel is not about guilt-tripping anxious parents of front-row kids; theyre suffering too, he says. But the credentialed have come to imagine themselves as smarter, wiser, more tolerant and therefore more deserving of recognition and respect than the noncredentialed. One reason for this, he suggests, lies in our American rhetoric of rising. Both rich and poor parents tell their kids, if you try hard enough, you can achieve your goals. For the upper strata, things may work out, but for the downwardly mobile blue collar and poor, theres a Catch-22. If they fail to reach their goals which a torpid economy almost guarantees they blame themselves. If only I could have gotten that degree, they say. Even the poorly educated, Sandel notes, look down on the poorly educated.

Donald Trump has reached out to this group with open arms I love the poorly educated. He has harvested their demoralization, their grief and their shame, most certainly if they are white. But, Sandel notes, two-thirds of all American adults lack four-year degrees. And in the wake of automation, in real wages, the white man without a B.A. earns less now than he did in 1979. The dignity of his labor has steeply declined. And since 1965, high-school-educated men in the very prime of life 25 to 54 have been slipping out of the labor force, from 98 percent in 1965 to 85 percent in 2015. Of all Americans whose highest degree is a high school diploma, in 2017 only 68 percent worked. And with rising deaths of despair, many are giving up on life itself. So you who are highly educated, Sandel concludes, should understand that youre contributing to a resentment fueling the toxic politics you deplore. Respect the vast diversity of talents and contributions others make to this nation. Empathize with the undeserved shame of the less educated. Eat a little humble pie.

But we are left with an important issue Sandel does not address: the targeting by the right wing of colleges themselves. This isnt new: Running parallel to the rise of the meritocracy in America has been a suspicion of the egghead who cant skin a rabbit, build a house or change a tire. As the historian Richard Hofstadter observed in Anti-Intellectualism in American Life, and Tocqueville before him, many Americans have valued not simply the cultivated intelligence of heroes in a culture of merit but also the creative genius of the common man in a culture of survival.

Today this has taken a shockingly partisan turn. For the first time in recent history, the less education you have, the more you lean right and distrust higher education itself. In a 2019 Pew survey, 59 percent of Republicans (and Republican-leaning independents) agree that colleges have a negative effect on the way things are going in the country these days, whereas only 18 percent of Democrats (and those leaning left) agree.

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Whats Wrong With the Meritocracy - The New York Times

Covid-19: What you need to know today – Hindustan Times

How seriously does one take Dr Li-Meng Yan? And how seriously does one take the paper Unusual Features of the Sars-CoV2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of its Probable Synthetic Route, published by her and co-authors, under the aegis of the Rule of Law Society and the Rule of Law Foundation, New York, on September 14? As the title suggests, the paper claims the coronavirus was man-made, in a laboratory.

The paper was uploaded on open-source research repository Zenodo, run by CERN, and was reported by Hindustan Times on Wednesday (bit.ly/33uFyy4). It wasnt as widely reported as Dr Yans comments in Loose Women, a segment of a TV show hosted by a UK TV channel, on which she pretty much said the same thing, albeit without any of the scientific arguments -- unsubstantiated ones -- presented in the paper.

Heres what that paper claimed:

One, ZC45, a bat virus, or a closely related variant or mutant, bears a striking similarity with Sars-CoV2, as shown by genome sequencing, with a 94%-100% similarity of key viral proteins.

The spike protein of Sars-CoV2 is essentially a trimer (essentially three parts) each of which has an S1 and S2 part with a furin cleavage site at the boundary between the two. Other research has already established that the human cellular enzyme furin cleaves, or breaks, the S1 and S2 unit at the cleavage site, and that the S1 unit then attaches to the ACE receptor, another protein found on the surface of most human cells. This binding then facilitates the entry of the viral protein into human cells. The virus ability to bind with the receptor, and the presence of the cleavage site that responds to a cannon human enzyme, are the reasons Covid-19 is as infective as it is.

Click here for complete coverage of the Covid-19 pandemic

Both the furin cleavage site, and the binding ability of the spike protein with the ACE2 receptor arent natural, the paper argued.

In their preface to this scientific hypothesis, the authors also claim that the process of creating such a virus in a laboratory could take only six months. They ask for further research and investigation into the origin of the virus. Even if their hypothesis is subsequently proven erroneous, this is a recommendation that no can argue with the origin of the virus needs to be investigated, not so much to assign blame (although there will be some that too), but to prepare for the next virus and the next pandemic.

Dr Yan, currently in the US, where she fled to in late April, is a virologist who used to work at the University of Hong Kong School of Public Health, and who has for long claimed that China knew of the virus and the fact that human-to-human transmission of the infection was happening, long before it let on. Her claims on the virus being man-made are more recent.

Interestingly, a March paper in Nature titled The Proximal Origin of Sars-Cov2, authored by Kristian G Andersen of Californias Scripps Research Institute, argued, again picking on the same two distinctive features of Sars-CoV2, that the virus was natural. The viral protein showed a high affinity to bind with the receptor, they said, but this interaction wasnt ideal or optimal. In plain English this meant that if anyone had set out to engineer the virus, they would have picked the ideal binding relation, not just another optimal one. The paper also said that there were other coronaviruses that had similar cleavage sites and that this wasnt unique to Sars-CoV2.

However, the two papers differ in one significant aspect. The one published in Nature said the genetic data irrefutably show that Sars-CoV2 is not derived from any previously used virus backbone. Dr Yans said (again, without substantiation that) a genomic sequence analysis reveals that ZC45, or a closely related bat coronavirus, should be the backbone used for the creation of Sars-CoV2.

Also read|Over 5,000 Indians died in West, East Asian countries amid Covid-19 pandemic: Govt informs Parliament

Dr Yans claims are also being seen through a political lens, with scientists in the US pointing out that the two non-profits that published the paper were linked to Steve Bannon, former Trump adviser and former executive chairman of the far-right Breitbart News, casting aspersions on the studys findings.

Clearly, only further research and investigation can shed light on the origin of the virus which has thus far infected 29,927,685 and killed 942,564 around the world. India ended Wednesday with 5,115,846 cases and 83,230 deaths.

But as Vivek Wadhwa, a columnist for this paper, a top technology thinker, and distinguished fellow at Harvard Law Schools Labor and Worklife Program, said in a recent article in Foreign Policy: If genetic engineering wasnt behind this pandemic, it could very well unleash the next one. Thats because, genetic engineering with all its potential for good and bad has become democratised, Wadhwa wrote.

Thanks to a technological revolution in genetic engineering, all the tools needed to create a virus have become so cheap, simple, and readily available that any rogue scientist or college-age biohacker can use them.

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Covid-19: What you need to know today - Hindustan Times

CRISPR Market to Witness Exponential Growth by 2020-2027 | Leading Players Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR…

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CRISPR Market to Witness Exponential Growth by 2020-2027 | Leading Players Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR...

Indian farmers cant wait anymore, they are sowing seeds of GM crops one Bt brinjal at a time – ThePrint

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Earlier this month, the Narendra Modi government reportedly sanctioned biosafety field trials of two new transgenic varieties of brinjal, developed by a public sector research institute. The news created quite the buzz.

Brinjal is among the most widely available and consumed vegetables in India, after potato, onion and tomato. But a brinjal crop is susceptible to pests, particularly the fruit and shoot borer (FSB), which often affects 50-80 per cent of the crop. Farmers frequently spend over half their input costs on pest control, and insecticides may have to be sprayed 30 to 70 times in a five-month crop cycle.

Many farmers spray products derived from naturally occurring soil bacterium, Bacillus thuringiensis (Bt), as a bio-pesticide to control several destructive pests, particularly in vegetable crops. But now, advanced molecular biology tools have enabled scientists to identify certain genes in the bacterium that produce insecticidal proteins that specifically kill a certain group of insect pests, and incorporate them in the desired plant by genetic engineering. When the target insects feed on such transgenic plants, they ingest Bt protein and get killed. Thus, this technology provides a built-in control mechanism against the pests, thereby greatly reducing the need to use chemical insecticides. Bt Brinjal has been developed to achieve this objective.

Also read: GM brinjals are helping Bangladesh farmers earn more, save more, study finds

There are two basic technology platforms offering Bt Brinjal today. One, developed by Maharashtra-based company Mahyco, is built on the gene Cry1Ac, with the event EE-1. This has been commercially grown in Bangladesh since 2013. Another Bt Brinjal technology was indigenously developed by the Indian Agriculture Research Institute (IARI), using the gene Cry1Fa1, with the Event-142.

Bt Brinjal Cry1Ac, EE-1: 2001 to 2010

Bt Brinjal Cry1Fa1, Event-142: 2001-2010

This transgenic Bt Brinjal expressing the gene Cry1Fa1 was developed by IARI in 2001-2004.

But eventually, the science of both these Bt Brinjals failed the political test. On 9 February 2010, the Ministry of Environment, Forest and Climate Change (MoEF) announced an indefinite moratorium on Bt Brinjal following a round of national consultations. Subsequently, all field trials of the GM crops were stopped in 2013.

Also read: APMC laws had shackled farmers, Modi govts ordinance makes them as free as other sectors

In 2009, Bangladesh began tests and trials for Bt Brinjal Cry1Ac with EE-1. It approved the first Bt Brinjal (EE-1) variety for commercial release, with 20 farmers sowing the new seeds in 2013.

The year 2018 marked the fifth anniversary of Bt Brinjal in Bangladesh. During its meeting in September 2018, the GEAC noted that nearly 50,000 farmers in Bangladesh were growing Bt Brinjal.Over 27,000 farmers had adopted Bt brinjal in 2017-18, not including the farmers who had saved their own seeds from the previous season.

The International Food Policy Research Institute (IFPRI), together with Bangladesh Agricultural Research Institute (BARI), carried out a randomised control trial among Bt Brinjal and non-Bt Brinjal farmers in Bangladesh in 2018. The key findings showed that net yields were 42 per cent higher for Bt Brinjal farmers. The Bt Brinjal farmers also witnessed a 31 per cent reduction in costs per kg of produce, and a 27.3 per cent increase in gross revenue per hectare.

While the quantity of pesticides used decreased by 39 per cent, the rate of FSB infestation in Bt Brinjal plants was only 1.8 per cent, in contrast to 33.9 per cent of the other. A report published in 2020, assessed the impact based on a survey of brinjal farmers in five districts. Results indicated that Bt Brinjal provided an average of 19.6 per cent higher yield and 21.7 cent higher revenue compared to non-Bt varieties.

Bangladesh recognises that Bt Brinjal needs to be made available in more varieties suitable for different agro-climatic areas in the country, and in varieties that appeal to local tastes.

Also read: Halt Bt brinjal trials, it is against the national interest, RSS affiliate writes to Modi

Prime Minister Modis 2014 claim that there was a possibility of genetic engineering in ancient India raised expectations among many farmers on the prospects of genetically modified (GM) crops. But here is a glance at what really happened to the GM crops.

Also read: Why farmers are still having to protest for their right to sow GM seeds, even in a pandemic

The second decade of the 21st century, 2011 to 2020, has turned out to be the lost decade for India, as far as agriculture biotechnology is concerned. The GEAC has held only 35 meetings in 10 years, and even recommended trials were not held. This contrasts sharply with the previous decade, when the GEAC held almost 81 meetings, and over a dozen GM crops were in various stages of development.

In May 2020, the GEAC, once again granted permission to BSSPL to conduct BRL-II confined field trials with two transgenic Bt Brinjal hybrids (Event-42), in at least two of the eight designated states, provided the state governments issue NOCs. This is a repeat of the recommendations for confined field trials issued in 2010, and again in 2014, both of which had failed to make any difference on the ground. In September, BSSPL said that it hopes to begin the field trials in April 2021.

This chronology of Bt Brinjals development in India suggests that policymakers have merely used the regulatory mechanism to avoid taking a clear decision, focussing on hypothetical risks rather than real ones. The endless demand for trials and tests only suggests that in the name of science, there is an attempt to choke the progress of science and stop its adoption for practical use.

This is a complete reversal of the fundamental legal philosophy of modern civilisation, which holds that one is innocent unless proven guilty. The yardstick now being used for GM crops is that these crops are inherently dangerous, and therefore presumed guilty, unless it can be shown that they are not. But a negative can never be proven.

As any toxicologist knows, it is the dosage that makes a poison.

Increasingly, it is the farmers, who bear the daily risks of agriculture, who are now speaking up in support of technologies that could reduce their risks and improve their wellbeing. It is the farmers who are defying the legal diktat. By taking the risk of sowing unapproved GM crops without any assurance of quality, they are engaging in the largest field trial ever possible. These brave farmers are demonstrating their capacity to take on the risk society is imposing on them by denying them access to new technologies, including GM crops.

Indian farmers are the true representatives of Aatmanirbhar Bharat, and their produce is the original Make in India, long before these slogans were coined.

The author isan independent policy analyst and the former founder-director of Liberty Institute.He has an interest in agriculture reforms and is working with farmers networks on the ground. Views are personal.

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Indian farmers cant wait anymore, they are sowing seeds of GM crops one Bt brinjal at a time - ThePrint

Microbes, the third pillar in the alternative protein industry: ‘The rationale is simple: Fermentation is just more efficient’ – FoodNavigator-USA.com

Its early days, says the Good Food Institute (GFI), but microbial fermentation is rapidly emerging as the third pillar in the alternative protein industry [alongside cell-cultured and plant-based]," attracting $435m in investment capital in 2020 alone.

Right now, producing protein whether from peas and soybeans or cows and chickens is resource-intensive and time-consuming, requiring large amounts of land, energy and water, says the GFI, which has just released a 72-page reporton fermentation in the alternative protein industry, arguing that itspotential is still largely untapped.

Put another way, it takes years to grow animals, and months or years to grow plants, while microbes can double their biomass in a matter of hours, as Natures Fynd CEO Thomas Jonas recently observed: Microbes are pretty damn efficient. They make great protein and they do it really fast.

Many microorganisms also offer innately high protein content (over 50% by dry weight) coupled with extraordinarily fast and self-sufficient growth, requiring only simple and inexpensive nutrient feedstocks, noted the GFI.

Fermentation-based products can also be manufactured from a distributed network of local production facilities using a fraction of the land, water, and inputs required to raise and feed animals with the added appeal of consistent quality, a lack of price volatility, and security of supply (plus it does not require killing animals on an industrial scale).

While many food ingredients, from enzymes (chymosin, a coagulating enzyme used in cheese production) to sweeteners (Reb M), vitamins (B12, Riboflavin), and colors (beta carotene) have been made via microbial fermentation for years, investment in a new wave of fermentation players focused on the alternative protein industry has exploded over the past two years.

Approaches vary, with some startups using synthetic biology (so-called precision fermentation) to write DNA sequences that can be inserted into microorganisms to instruct them to produce substances currently produced by mammals, from whey and casein proteins (Perfect Day), egg white (Clara Foods), and collagen (Geltor) to proteins found in human breast milk (Triton Algae Innovations).

Other are deploying precision fermentation to produce components that are found in plants, but can be produced more efficiently via fermentation. For example, Impossible Foods uses a genetically engineered yeast strain to produce its flagship meaty-tasting and red-colored ingredient leghemoglobin - heme - which is found in nodules attached to the roots of nitrogen-fixing plants such as soy.

A third group of companies (using so-called biomass fermentation) such as Natures Fynd,Meati Foods, Brewed Foods (Plentify), Air Proteinand Noblegen are growing naturally occurring organisms from protists and bacteria to extremophiles that are inherently high in protein.

Globally, fermentation companies devoted to alternative proteins received more than $274m in venture capital funding in 2019 and $435m in the first seven months of 2020 from investors such as Bill Gates-backed Breakthrough Energy Ventures, Temasek and Horizons Ventures to major CPG and ingredients players such as Kellogg, ADM, Danone, Kraft Heinz, Mars and Tyson.

By mid-2020, 44 fermentation companies focused on alternative proteins had formed around the globe, while several of the worlds largest food and life science companies, including DuPont, Novozymes, and DSM, have also been developing fermentation-derived product lines and solutions tailored to the alternative protein industry, said GFI.

But they're still just scratching the surface, argued report authors Dr Liz Specht and Nate Crosser.

While fermentation has a rich history of use in food, as the modern era has demonstrated, its innovative potential is still largely untapped.

The vast biological diversity of microbial species, coupled with virtually limitless biological synthesis capabilities, translates to immense opportunity for novel alternative protein solutions to emerge from fermentation-based approaches.

Fermentation is a key means of producing animal-origin-free growth factors for cell-cultured meat production, with firms such as ORF Genetics, Richcore, and Peprotech now working in this space.

While some of the strain development work to identify and optimize microbes with potential in this segment uses tools such as gene editing and genetic engineering, noted the GFI, vast progress is also possiblethrough simple adaptation and breeding strategies powered by advanced genomic insights.

The urgency of the moment calls for bold research to explore novel hosts that could significantly outperform the incumbents.

More work is also needed to identify more cost effective or sustainable feedstocks (for the microbes) via converting waste products or agro-industrial byproducts into high-quality protein biomass, says the GFI, noting that the extremophile microorganism developed by Natures Fynd, for example, exhibits wide metabolic flexibility and therefore suitability to diverse feedstocks.

The organism used byAir Protein,meanwhile, uses components found in the air - notably carbon dioxide as feedstock.

This is just the beginning: The opportunity landscape for technology development is completely untapped in this area. Many alternative protein products of the future will harness the plethora of protein production methods now available, with the option of leveraging combinations of proteins derived from plants, animal cell culture, and microbial fermentation.

Dr. Liz Specht, associate director of science and technology, The Good Food Institute

But what about price?

According to the GFI, there is reason to believe that fermentation can achieve price parity with most products through a combination of approaches including increasing scale, improving volumetric productivity (better yields), and prolonging continuous bioprocessing (the longer a process runs continuously at its peak in steady-state growth, the more efficient the overall run will be because the cells are continuously harvested from their maximum productivity).

Fermentation is not just valuable in its own right, offering competitive prices, unparalleled functionality and scalability, and validated mechanisms for establishing and ensuring safety; it stands to revolutionize the entire alternative protein industry, with spillover applications in both plant-based products and cultivated meat.

In 2019, fermentation companies raised over 3.5 times more capital than all cell-cultured meat companies combined.

One aspect of the technology that is less explored in the report is consumer perception, which is less of an issue for companies using microbes to produce ingredients consumers already recognize such as whey or collagen, but could present novel challenges for companies making new-to-the-world ingredients, as Lever VC managing partner Nick Cooney told FoodNavigator-USA in a recent interview.

Consumer acceptance is definitely something we think about in the alternative proteins space when were evaluating companies, and I do think there will be an increased challenge for companies producing novel proteins.

Clearly, bacteria-sourced protein is not something youd find in Grandmas kitchen cupboard, Brewed Foods co-founder Dr Jonathan Gordon, told Food Navigator-USA.

But its not some kind of sci-fi fantasy either, he stressed:The notion of consuming bacteria has become very well established thanks to probiotics, although in our case, the bacteria are not live, but are fully deactivated, so theyre entirely dead, and non spore-forming.

KarunaRawal, CMO at Natures Fynd, added: What we found was that consumers just want to know what it is [the protein source], they dont like it when companies cloud things in[euphemistic]language, and we dont want to confuse anyone.

But Id say were in a different time to when Quorn[a soil micro-organism described on pack as mycoprotein]came to market and since then, the notion of good bacteria, and fermented products have become very mainstream and the landscape has changed.

The GFI breaks the market down into three segments:

Perfect Day,a startup producing milk proteins via microbial fermentation (minus the cows), recently expanded its Series C round from a previously-announced $140m, up to $300m through a new tranche led by CPP Investments and bolstered by long-time supporters Temasek and Horizons Ventures.

The cash injection -bringing its cumulative funding to over $360m -was announced as Berkeley, Calif.-based Perfect Day revealed a series of incremental improvements in recent months enabling it to increase the efficiency of its production process, substantially reducing costs two years ahead of expectations.

While Perfect Day is a b2b company, it recently moved into the b2c space via spinoff The Urgent Company, which is focused on consumer brands, beginning with animal-free ice cream Brave Robot.

Plentify a novel protein sourced from a strain of bacteria that naturally produces high levels of protein is more efficient to produce than plant-based proteins, and compared to animal husbandry, is ludicrously efficient,"claims Brewed Foods co-founder Dr Jonathan Gordon.

The obvious advantage here is the incredible compactness of production. You can basically use waste products to fuel the process. We can produce tons of protein in an incredibly small footprintconsistently and efficiently.

"Protein production is also the primary purpose of the process[whereas most plants harvested for protein also contain large quantities of starch, oil or other components that producers need to find a market for, both for economic and sustainability reasons].

Air Protein(which utilizes single-cell organisms called hydrogenotrophs first studied by NASA in the 1960s),is using components found in the air - notably carbon dioxide - as a low-cost feedstock.

See the article here:

Microbes, the third pillar in the alternative protein industry: 'The rationale is simple: Fermentation is just more efficient' - FoodNavigator-USA.com

The limits of synthetic biology through the origins of SARS-CoV-2 – Drug Target Review

Conspiracy theories about COVID-19 have been spreading since the early days of the outbreak. But how do we know whether a biological entity is artificially made or has occurred naturally? Marc Baiget Francesch explores the capabilities of current scientific approaches in terms of virus engineering and how this applies to the present pandemic.

OVER THE LAST few months, numerous theories relating to the origin of the novel coronavirus SARS-CoV-2 have invaded the internet. Sometimes, these theories can give rise to more interesting discussions than what is originally intended by the authors. For example, the theory that the new coronavirus has been purposely made as a biological weapon would mean that SARS-CoV-2 is a synthetic organism, which simultaneously implies that scientists can create synthetic viruses. How much truth is there in that implication? How far can current technologies go in terms of artificial microorganisms design? To answer these questions, we first need to understand the current state of synthetic biology as a field and acknowledge its limitations.

While making a new virus from scratch is not technically impossible, it would require a level of knowledge that is implausible to imagine in any scientific institution at present

Synthetic biology greatly relies on predictive models and computer simulated structures. Computer programmes use the information collected by years of research in molecular biology, which is stored in huge libraries of microorganisms, molecules and domains, to explore their potential when modified or combined in silico that is, on a computer. The idea of these programmes is to form combinations that, presumably, do not exist in nature in order to analyse potential structures for multiple uses. However, despite in silico models providing valuable information and saving time and money on in vitro experimentation, they are far from perfect.

Professor JA Davies, from the University of Edinburgh, published a paper in the open access journal Life that analysed the current flaws of the engineering approach in synthetic biology. While he recognises that this approach, based on the design-build-test dogma, is interesting and that relying on standard pre-existing parts simplifies the overall design of synthetic structures, it lacks biological understanding.1

In biology, every component from a microorganism has a metabolic cost, ie, the more components you add to a cell, the less energy the cell can direct to each part. Therefore, the fewer parts used for a function, the better. In genetic engineering this is a crucial consideration, since adding new genes normally supposes that pre-existing genes are deleted in order for the organism to be viable. In addition, the interactions between two different pre-existing parts might affect its original function. Hence, as Professor Davies argues, using a novel part, designed for a specific function, might prove easier than trying to reproduce the same function with two pre-existing ones. Ultimately, evolution is based on constant changes of previous structures induced by a huge number of factors and not on the combination of unchanging structures. So, while synthetic biology can cover a lot of unexplored possibilities, it is still far from being an almighty tool or competing with natural evolution.

This brings us to the next question: how capable are current scientific approaches in terms of virus engineering? Researchers can recreate an existing virus from scratch, and this is what many research teams have been attempting since the coronavirus started to spread in order to understand the virus better.2 However, creating a new one is another story. It is possible to create new viruses from original ones; though, there are some restrictions. As aforementioned, synthetic biology relies on the use of pre-existing parts, which means we would need to use different parts of existing viruses and assemble them in order to produce a new virus. Dr Robert F Garry, a microbiologist specialising in virology, commented in Business Insider that there is no consensus on what exactly makes a virus pathogenic.3 Therefore, while making a new virus from scratch is not technically impossible, it would require a level of knowledge that is implausible to imagine in any scientific institution at present. Nevertheless, our current knowledge of molecular science allows us to identify potentially man-made structures or microorganisms.4 This is possible because they are based on pre-existent parts; an engineered virus would have identifiable segments of DNA that belong to other viruses whose sequences are stored in libraries. This means that we should be able to identify if a new virus was artificially designed or is a product of natural evolution.

To study the case of the novel coronavirus, we need to have access to its genetic sequence. This has been a major advancement in epidemiology, as for previous pandemics researchers had to wait from months to years in order to study the microorganism responsible for the outbreak, whereas the structure of SARS-CoV-2 was available within weeks. By analysing its genetic structure, scientists have realised that the backbone of the virus is, indeed, a new one.5 However, this does not mean that the virus was not artificially made; we just know that the backbone was not copied from another virus.

What about prompting an existent virus to mutate? It could be that biotechnologists induced mutations to a known virus in order to produce a novel one, like what we see in nature. However, when scientists evaluated the structure of SARS-CoV-2 and compared it to other viral structures, the closest relative they found was SARS-CoV RaTG13, which showed a 96 percent similarity to the novel coronavirus.6 Although 96 percent may seem a lot, considering the size of SARS-CoV-2, which is close to 30,000 nucleotides long, this four percent difference is quite significant around 1,200 nucleotides.7

Studying evolution and natural processes is key for synthetic biology to expand and become an even more powerful tool

Nevertheless, there may still be some resistance to debunking certain theories. One might argue that, while using known parts of similar viruses, targeted mutations could have been applied to give the virus the ability to attach to human cells which is essentially what makes this virus able to infect humans. One of the most curious facts about the coronavirus is that the receptor binding domain the part that makes SARS-CoV-2 able to attach to human cells was simulated in silico once the sequence of the virus was made available. This sequence showed poor efficiency on the simulations, meaning that nature has found a mechanism that we had not been able to predict.3 If we put together all the facts and reflect on the fact that 75 percent of the new emerging diseases are from zoonotic origin, it appears the theories around SARS-CoV-2 being a man-made virus are quite unrealistic, to say the least.8

Something I have found interesting since the search of the origin of the SARS-CoV-2 started, is that we have confirmed that synthetic biology still has a long way to go. We still need to understand a lot about nature to get a bigger picture of how things work and to grasp all the possibilities that molecular biology has to offer. Studying the evolution of viruses not only benefits the epidemiologists, but also the synthetic biologists, who gain insights into how molecular interactions work. This newfound knowledge can be used to improve current models and propose frameworks for the creation of new molecules. Therefore, one can conclude that studying evolution and natural processes is key for synthetic biology to expand and become an even more powerful tool.

Marc Baiget Francesch is an MSc in Pharmaceutical Engineering and currently works as an Assistant Editor for the International Journal of Molecular Sciences. He also writes articles and innovation grants as a freelancer.

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The limits of synthetic biology through the origins of SARS-CoV-2 - Drug Target Review