Expanding access to the world’s top medical minds – MIT News

Earlier this year, a little girl was struggling with a neurological condition that caused her to have 20 to 30 seizures a day. Her parents were working with a neurologist on a treatment plan, but they wanted a second opinion. Rather than trying to find a far-away, top-rated neurologist to get an appointment with, they used the services of InfiniteMD, a company that virtually connects patients and their families with some of the top medical specialists in the world.

Through the service, a leading pediatric neurologist reviewed a summary of the girls medical records and advised a different medication. Today, the girl is nearly seizure-free and is being weaned off some of her previous treatments. The parents report their daughter is now regaining the ability to eat soft food and is laughing and kicking playfully during bath times.

The breakthrough shows the power of broadening access to the worlds leading medical minds. Thats what InfiniteMD has been doing for the last four years, often with dramatic results.

The company combines a network of top physicians with a platform that pairs patients with specialists, organizes patient files for review, and facilitates connections via video chats or written reports. The consultations can help patients with treatment plans, diagnoses, test results, and more.

Second opinions and expert consults are inherently complex, InfiniteMD co-founder and Chief Operating Officer Christopher Lee PhD 18 says. Someone has a serious diagnosis or disease, then they have 30 minutes or 60 minutes to share everything about their care with a world-leading expert. In order for [the specialist] to be brought onto the same page and create a valuable interaction, there are a million moving parts that need to come together.

Today, nearly 5 million people have access to InfiniteMDs platform, primarily through their employers. The company says that over 70 percent of its consultations lead to a revised treatment plan, and more than a fifth of consultations lead to a revised or corrected diagnosis.

As Covid-19 has increased the demand for telehealth services, InfiniteMDs team has taken steps to bolster its offerings in hopes of further improving access to the worlds top physicians. In August, the company agreed to be acquired by ConsumerMedical, a large organization that helps guide patients through the health care system, among other patient advocacy work.

Right now, we basically say to patients, for example, You shouldnt get this surgery, you should do physical therapy instead, InfiniteMD co-founder and Chief Executive Officer Babak Movassaghi MBA 14 says. But then what? Where should patients go? ConsumerMedical has an algorithm to connect you with the right doctor. They can make an appointment for you, and follow up with you, so [the acquisition] just made sense.

A problem thats personal

Movassaghi had an unconventional path to entrepreneurship, having first enjoyed a 13-year football career in NFL Europe before studying theoretical physics as a graduate student in his home country of Germany. After earning his PhD in medical physics from the University of Utrecht in 2005, he began a career in the health care industry. But a passion for entrepreneurship brought him to MIT, first to participate in the MIT Sloan School of Managements Entrepreneurial Development Program (EDP) in 2011, then as part of the Sloan Fellows program two years later.

While Movassaghi was at Sloan, Lee was beginning his PhD in the Harvard-MIT Program in Health Sciences and Technology. The two students decided to team up for an MIT Hacking Medicine event, and went on to pursue various startup ideas throughout their time at MIT.

In 2015, Movassaghis close relative in Europe was diagnosed with cancer. He asked for their medical records, translated them from German to English, and had a contact at the Dana-Farber Cancer Institute take a look. The experience sparked an idea that resonated with both founders.

We have immigrant backgrounds, and weve both been lucky to be educated, and weve both been very keen to playing a role for our family and extended family as health care advocates, says Lee, who studied biomedical engineering before coming to MIT. We realized this isnt just a problem that affects us, it affects everyone around the world.

Working on the idea as part of MITs Healthcare Ventures course, the founders pieced together existing services like Zoom to make a prototype. They also brought on a third co-founder, Harvard Medical School trained physician Liz Kwo, who was crucial in building the companys early network of physicians. Kwo initially served as CEO but left the company in 2018.

Although the founders initially focused on helping international patients, they began expanding access to their service in the U.S. through partnerships with large employers and health insurers.

Today about 80 percent of InfiniteMDs cases come from the U.S. The companys network of more than 2,400 medical specialists were chosen based on their affiliations with leading hospitals, their experience, and research publications.

InfiniteMDs software condenses disparate patient medical records into two-page summaries for doctors that can include things like MRIs and ultrasound images. The company can also facilitate collaboration between experts in different medical fields to handle complex cases.

When it comes to connecting patients and doctors, InfiniteMD can schedule live video consultations or, depending on patient preference, the two sides can communicate via asynchronous video snippets or messaging.

Overall, the company has focused on streamlining the telemedicine experience for patients and doctors without losing the value of expert consultations.

For the patients, it couldnt be more simple: Its basically, Hi, I have this, these are my questions, Lee says. On the back end, we have all these different roles for different people to allow thousands of these cases to be managed. Physicians also want it to be super simple. Theyre like patients they barely remember their log-ins. So we made an interface thats also super easy for the physicians.

Making every medical expert local

Movassaghi says InfiniteMDs services have helped people avoid thousands of unnecessary surgeries in the U.S. over the years. One woman, a former Olympic skier, was scheduled to have her leg amputated before a second opinion facilitated by InfiniteMD led to a less life-altering procedure. Today the woman sends the founders pictures of herself hiking.

Covid-19 has changed things dramatically for InfiniteMD as more people prefer virtual consultations instead of hospital visits. With the ConsumerMedical acquisition, the founders, who will be joining the larger company, say they can move from a point solution to a part of a larger service to help patients get the most out of the health care system.

With Covid-19, weve proven a lot of things are possible from home, and so theres going to be an increase in virtual offerings, Lee says. Everything from physical therapy to wellness to simple checkups, all of these are headed in the direction of virtual. The beautiful thing about InfiniteMD is were agnostic in terms of what information is delivered. Were really in the information business, so all of those offerings can be slotted into the IMD platform easily.

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Expanding access to the world's top medical minds - MIT News

Stem cells can repair Parkinson’s-damaged circuits in mouse brains – University of Wisconsin-Madison

The mature brain is infamously bad at repairing itself following damage like that caused by trauma or strokes, or from degenerative diseases like Parkinsons. Stem cells, which are endlessly adaptable, have offered the promise of better neural repair. But the brains precisely tuned complexity has stymied the development of clinical treatments.

In a new study addressing these hurdles, University of WisconsinMadison researchers demonstrated a proof-of-concept stem cell treatment in a mouse model of Parkinsons disease. They found that neurons derived from stem cells can integrate well into the correct regions of the brain, connect with native neurons and restore motor functions.

The key is identity. By carefully tracking the fate of transplanted stem cells, the scientists found that the cells identity dopamine-producing cells in the case of Parkinsons defined the connections they made and how they functioned.

Coupled with an increasing array of methods to produce dozens of unique neurons from stem cells, the scientists say this work suggests neural stem cell therapy is a realistic goal. However, much more research is needed to translate findings from mice to people.

Su-Chun Zhang talks with a postdoctoral student in his research lab at the Waismam Center. Photo: Jeff Miller

The team, led by UWMadison neuroscientist Su-Chun Zhang, published its findings Sept. 22 in the journal Cell Stem Cell. The research was led by Zhang lab postdoctoral researchers Yuejun Chen, Man Xiong and Yezheng Tao, who now hold faculty positions in China and Singapore.

Our brain is wired in such an accurate way by very specialized nerve cells in particular locations so we can engage in all our complex behaviors. This all depends on circuits that are wired by specific cell types, says Zhang, a professor of neuroscience and neurology at UWMadisons Waisman Center. Neurological injuries usually affect specific brain regions or specific cell types, disrupting circuits. In order to treat those diseases, we have to restore these circuits.

To repair those circuits in the Parkinsons disease mouse model, the researchers began by coaxing human embryonic stem cells to differentiate into dopamine-producing neurons, the kind of cells that die in Parkinsons. They transplanted these new neurons into the midbrains of mice, the brain region most affected by Parkinsons degeneration.

Several months later, after the new neurons had time to integrate into the brain, the mice showed improved motor skills. Looking closely, Zhangs group was able to see that the transplanted neurons grew long distances to connect to motor-control regions of the brain. The nerve cells also established connections with regulatory regions of the brain that fed into the new neurons and prevented them from being overstimulated.

Both sets of connections feeding in and out of the transplanted neurons resembled the circuitry established by native neurons. This was only true for dopamine-producing cells. Similar experiments with cells producing the neurotransmitter glutamate, which is not involved in Parkinsons disease, did not repair motor circuits, revealing the importance of neuron identity in repairing damage.

To finally confirm that the transplanted neurons had repaired the Parkinsons-damaged circuits, the researchers inserted genetic on-and-off switches into the stem cells. These switches turn the cells activity up or down when they are exposed to specialized designer drugs in the diet or through an injection.

When the stem cells were shut down, the mices motor improvements vanished, suggesting the stem cells were essential for restoring Parkinsons-damaged brains. It also showed that this genetic switch technology could be used to fine-tune the activity of transplanted cells to optimize treatment.

Zhang found that neurons derived from stem cells can connect with native neurons and restore motor functions. But more research is needed to translate the findings from mice to people.

The Zhang group and other researchers have spent years developing methods to turn stem cells into the many different types of neurons within the brain. Each neurological disease or injury would require its own specialized nerve cells to treat, but the treatment plans would likely be broadly similar. We used Parkinsons as a model, but the principle is the same for many different neurological disorders, says Zhang.

The work has personal meaning to Zhang. As a physician and scientist, he often receives letters from families desperate for help treating neurological disorders or brain trauma. Its also an experience he can relate to. Six years ago, Zhang was in a bike accident and broke his neck. When he awoke partially paralyzed in the hospital, his first thought was of how stem cells which he had already researched for years could help him recover.

Now, largely rehabilitated after years of physical therapy, Zhang still believes that the right stem cell treatments could, in the future, help people like him and the families he hears from.

To that end, Zhangs group is currently testing similar treatments in primates, a step toward human trials.

There is hope, but we need to take things one step at a time, he says.

This work was supported in part by the National Institutes of Health (grants NS096282, NS076352, and NS086604, MH099587 and MH100031).

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Stem cells can repair Parkinson's-damaged circuits in mouse brains - University of Wisconsin-Madison

Pediatric Neurology Device Market Detailed analysis of current Industry figures with forecasts growth by 2026 | Elana, Inova Healthcare System,…

Pediatric Neurology Device Market Scenario 2020-2026:

The Global Pediatric Neurology Device market exhibits comprehensive information that is a valuable source of insightful data for business strategists during the decade 2014-2026. On the basis of historical data, Pediatric Neurology Device market report provides key segments and their sub-segments, revenue and demand & supply data. Considering technological breakthroughs of the market Pediatric Neurology Device industry is likely to appear as a commendable platform for emerging Pediatric Neurology Device market investors.

This Pediatric Neurology Device Market Report covers the manufacturers data, including shipment, price, revenue, gross profit, interview record, business distribution, etc., these data help the consumer know about the competitors better.

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The complete value chain and downstream and upstream essentials are scrutinized in this report. Essential trends like globalization, growth progress boost fragmentation regulation & ecological concerns. This Market report covers technical data, manufacturing plants analysis, and raw material sources analysis of Pediatric Neurology Device Industry as well as explains which product has the highest penetration, their profit margins, and R&D status. The report makes future projections based on the analysis of the subdivision of the market which includes the global market size by product category, end-user application, and various regions.

Topmost Leading Manufacturer Covered in this report:Elana, Inova Healthcare System, Medtronic, The Nemours Foundation, Stryker, Boston Scientific, B.Braun Melsungen, Integra LifeSciences, St. Jude Medical

Product Segment Analysis: Neurosurgery Devices, Neurostimulator, Cerebrospinal Fluid (CSF) Management Devices

Application Segment Analysis:

HospitalsHealthcare CentersNeurological Research Centers

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Regional Analysis For Pediatric Neurology DeviceMarket

North America(the United States, Canada, and Mexico)Europe(Germany, France, UK, Russia, and Italy)Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)South America(Brazil, Argentina, Colombia, etc.)The Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

Market Synopsis:The market research report consists of extensive primary research, as well as an in-depth analysis of the qualitative and quantitative aspects by various industry specialists and professionals, to gain a deeper insight into the market and the overall landscape.

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To analyze and forecast the market size of Pediatric Neurology DeviceIndustry in theglobal market. To study the global key players, SWOT analysis, value and global market share for leading players. To determine, explain and forecast the market by type, end use, and region. To analyze the market potential and advantage, opportunity and challenge, restraints and risks of global key regions. To find out significant trends and factors driving or restraining the market growth. To analyze the opportunities in the market for stakeholders by identifying the high growth segments. To critically analyze each submarket in terms of individual growth trend and their contribution to the market. To understand competitive developments such as agreements, expansions, new product launches, and possessions in the market. To strategically outline the key players and comprehensively analyze their growth strategies.

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At last, the study gives out details about the major challenges that are going to impact market growth. They also report provides comprehensive details about the business opportunities to key stakeholders to grow their business and raise revenues in the precise verticals. The report will aid the companys existing or intend to join in this market to analyze the various aspects of this domain before investing or expanding their business in the Pediatric Neurology Device markets.

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Pediatric Neurology Device Market Detailed analysis of current Industry figures with forecasts growth by 2026 | Elana, Inova Healthcare System,...

COVID-19 Impact on 2015-2025 Fully Automatic Biochemistry Analyzer Market Research, Size, Growth And Trends 2020 to 2025 (Five Years Forecast)|…

The Fully Automatic Biochemistry Analyzer Markethas been riding a progressive growth trail over the recent past. The first two quarters of the year 2020 have however witnessed heavy disruptions throughout all the industry facets, which are ultimately posing an unprecedented impact onFully Automatic Biochemistry Analyzer market. Although healthcare & life sciences industry as a whole is witnessing an influx of opportunities in selected sectors, it remains a matter of fact that some of the industry sectors have temporarily scaled back. It becomes imperative to stay abreast of all the recent updates and predict the near future wisely.

The report primarily attempts to track the evolution of growth path of market from 2019, through 2020, and post the crisis. It also provides long-term market growth projections for a predefined period of assessment, 2020 2025. Based on detailed analysis of industrys key dynamics and segmental performance, the report offers an extensive assessment of demand, supply, and manufacturing scenario. Upsurge in R&D investments, increasing sophistication of healthcare infrastructure, thriving medical tourism, and rapidly introducing innovations in Fully Automatic Biochemistry Analyzer and equipment sector are thoroughly evaluated.

NOTE: Our team is studying Covid-19 impact analysis on various industry verticals and Country Level impact for a better analysis of markets and industries. The 2020 latest edition of this report is entitled to provide additional commentary on latest scenario, economic slowdown and COVID-19 impact on overall industry.

Request Free Sample Report Fully Automatic Biochemistry Analyzer industry outlook @ Key players in the global Fully Automatic Biochemistry Analyzer market covered in Chapter 4: Danaher, Roche, Siemens Healthcare, Abbott, Hitachi, Mindray Medical, Thermo Scientific, KHB, Abaxis, Horiba Medical, ELITech, Gaomi Caihong

In Chapter 11 and 13.3, on the basis of types, the Fully Automatic Biochemistry Analyzer market from 2020 to 2025 is primarily split into:General Type

In Chapter 12 and 13.4, on the basis of applications, the Fully Automatic Biochemistry Analyzer market from 2020 to 2025 covers:HospitalClinic

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:

United States, Canada, Germany, UK, France, Italy, Spain, Russia, Netherlands, Turkey, Switzerland, Sweden, Poland, Belgium, China, Japan, South Korea, Australia, India, Taiwan, Indonesia, Thailand, Philippines, Malaysia, Brazil, Mexico, Argentina, Columbia, Chile, Saudi Arabia, UAE, Egypt, Nigeria, South Africa and Rest of the World

Some Points from Table of Content

Global Fully Automatic Biochemistry Analyzer Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026

Chapter 1Report Overview

Chapter 2Global Market Growth Trends

Chapter 3Value Chain of Fully Automatic Biochemistry Analyzer Market

Chapter 4Players Profiles

Chapter 5Global Fully Automatic Biochemistry Analyzer Market Analysis by Regions

Chapter 6North America Fully Automatic Biochemistry Analyzer Market Analysis by Countries

Chapter 7Europe Fully Automatic Biochemistry Analyzer Market Analysis by Countries

Chapter 8Asia-Pacific Fully Automatic Biochemistry Analyzer Market Analysis by Countries

Chapter 9Middle East and Africa Fully Automatic Biochemistry Analyzer Market Analysis by Countries

Chapter 10South America Fully Automatic Biochemistry Analyzer Market Analysis by Countries

Chapter 11Global Fully Automatic Biochemistry Analyzer Market Segment by Types

Chapter 12Global Fully Automatic Biochemistry Analyzer Market Segment by Applications

Chapter 13Fully Automatic Biochemistry Analyzer Market Forecast by Regions (2020-2026)

Chapter 14Appendix

Impact of Covid-19 in Fully Automatic Biochemistry Analyzer Market: Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Fully Automatic Biochemistry Analyzer market in 2020. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

In the context of China-US trade war and COVID-19 epidemic, it will have a big influence on this market. Fully Automatic Biochemistry Analyzer Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China).

In this report, the global Fully Automatic Biochemistry Analyzer market is valued at USD XX million in 2020 and is projected to reach USD XX million by the end of 2024, growing at a CAGR of XX% during the period 2020 to 2024.

The report firstly introduced the Fully Automatic Biochemistry Analyzer basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

Points Covered in the Report

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COVID-19 Impact on 2015-2025 Fully Automatic Biochemistry Analyzer Market Research, Size, Growth And Trends 2020 to 2025 (Five Years Forecast)|...

Latest News:: Biochemical Diagnostic Reagent Market is expected to witness an exponential growth over forecast year 2020-2025| Roche, Siemens…

Global Biochemical Diagnostic Reagent Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19 Worldwide Spread)

Global Biochemical Diagnostic Reagent Market Report offers an entire study of the Impact of COVID-19 on Biochemical Diagnostic Reagent Market, Industry Outlook, Opportunities in Market, and Expansion By 2025 and also taking into consideration key factors like drivers, challenges, recent trends, opportunities, advancements, and competitive landscape. This report offers a clear understanding of this also as a future scenario of the worldwide Biochemical Diagnostic Reagent industry. Research techniques like PESTLE and SWOT analysis are deployed by the researchers. They need also provided accurate data on Biochemical Diagnostic Reagent production, capacity, price, cost, margin, and revenue to help the players gain a clear understanding of the general existing and future market situation.

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Biochemical Diagnostic Reagent Market competition by top manufacturers/Key player Profiled:Roche, Siemens Healthineers, Beckman Coulter, Randox, BioSino, Beijing Leadman Biochemistry, FosunPharma, Beijing Strong Biotechnologies, Dojindo Laboratories, Sysmex, KAINOS Laboratories, DAAN Gene

The study objectives of Biochemical Diagnostic Reagent Market report are: 1.To identify opportunities and challenges for Global Biochemical Diagnostic Reagent .2.To provide insights about factors affecting market growth. To analyze the Biochemical Diagnostic Reagent market based on various factors- price analysis, supply chain analysis, SWOT analysis, etc.3.To identify and analyze the profile of leading players involved within the manufacturing of worldwide Biochemical Diagnostic Reagent .4.To provide country-level analysis of the market regarding the present Biochemical Diagnostic Reagent market size and future prospective.5.To examine competitive developments like expansions, new product launches, mergers & acquisitions, etc., in Global Biochemical Diagnostic Reagent .6.To provide a detailed analysis of the market structure alongside forecast of the varied segments and sub-segments of the worldwide Biochemical Diagnostic Reagent market.

By Types, the Biochemical Diagnostic Reagent Market can be Splits into:

Liquid Double ReagentDry Powder Double Reagent

By Applications, the Biochemical Diagnostic Reagent Market can be Splits into:

HospitalClinicLaboratory

Global Biochemical Diagnostic Reagent Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during the 2021-2026. The report analyses the global Biochemical Diagnostic Reagent market, the market size and growth, as well as the major market participants.

The analysis includes market size, upstream situation, market segmentation, market segmentation, price & cost and industry environment. In addition, the report outlines the factors driving industry growth and the description of market channels.The report begins from overview of industrial chain structure, and describes the upstream. Besides, the report analyses market size and forecast in different geographies, type and end-use segment, in addition, the report introduces market competition overview among the

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Regions Covered in these Report:

Asia Pacific (China, Japan, India, and Rest of Asia Pacific)Europe (Germany, the UK, France, and Rest of Europe)North America (the US, Mexico, and Canada)Latin America (Brazil and Rest of Latin America)Middle East & Africa (GCC Countries and Rest of Middle East & Africa)

Global Biochemical Diagnostic Reagent Market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Biochemical Diagnostic Reagent Market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Reasons To Buy: Make strategic business decisions using in-depth historic and forecast market data associated with the Biochemical Diagnostic Reagent market, and every category within it.Extensive price charts draw particular pricing trends within recent yearsPosition yourself to realize the most advantage of the Biochemical Diagnostic Reagent markets growth potentialTo understand the latest trends of the Biochemical Diagnostic Reagent marketTo understand the impactful developments of key players within the market, their strategic initiatives and comprehensively study their core competencies

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Table of Contents

Report Overview:It includes major players of the global Biochemical Diagnostic Reagent Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the global Biochemical Diagnostic Reagent Market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the global Biochemical Diagnostic Reagent Market are discussed.

Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type:This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application:Besides an overview of the global Biochemical Diagnostic Reagent Market by application, it gives a study on the consumption in the global Biochemical Diagnostic Reagent Market by application.

Production by Region:Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region:This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

Company Profiles:Almost all leading players of the global Biochemical Diagnostic Reagent Market are profiled in this section. The analysts have provided information about their recent developments in the global Biochemical Diagnostic Reagent Market, products, revenue, production, business, and company.

Market Forecast by Production:The production and production value forecasts included in this section are for the global Biochemical Diagnostic Reagent Market as well as for key regional markets.

Market Forecast by Consumption:The consumption and consumption value forecasts included in this section are for the global Biochemical Diagnostic Reagent Market as well as for key regional markets.

Value Chain and Sales Analysis:It deeply analyzes customers, distributors, sales channels, and value chain of the global Biochemical Diagnostic Reagent Market.

Key Findings: This section gives a quick look at important findings of the research study.

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Latest News:: Biochemical Diagnostic Reagent Market is expected to witness an exponential growth over forecast year 2020-2025| Roche, Siemens...

Servoss and Thallapuranam to Jointly Serve as Co-Directors of Undergraduate Research – University of Arkansas Newswire

University Relations

Shannon Servoss, associate professor of chemical engineering, and Suresh Thallapuranam, professor of biochemistry, will serve as co-directors of undergraduate research.

During the summer months, theOffice of Research and Innovation conducted an internal search to fill the position of an undergraduate research director. Out of the candidate pool, two UofA professors impressed the panel with their career experience and passion for working with undergraduate students. Shannon Servoss, associate professor of chemical engineering, and Suresh Thallapuranam, professor of biochemistry, were offered appointments as co-directors of undergraduate research and both agreed to share the title and responsibilities thereof.

The duties of this position entail supporting undergraduate research and creative activities across academic disciplines. The two professors will report to Wesley Stites, associate vice chancellor for research and innovation. They will coordinate withHonors College and the Office of Research and Innovation to fulfill their mission. Tasks vary from year to year. For the 2020-2021 academic school year, duties will include relaunching the undergraduate research journal, Inquiry, engaging in conversations with colleges and departments to encourage research activity among non-Honors students, and gathering regular feedback from undergraduate participants and faculty mentors about how to maintain and improve programs.

We are thrilled to have Professors Servoss and Thallapuranam to take the leadership role for UAs Undergraduate Research Office, Vice Chancellor Daniel Sui said. As research increasingly becomes an integral part of the experiential learning experience for undergraduates worldwide, I am confident Professors Servoss and Thallapuranam will work with the rest of the faculty on campus to bring UAs undergraduate research to a new level of excellence in the coming years.

Servoss and Thallapuranam will also oversee the implementation of improvements in student programs and routinely assess their effectiveness. They will also frequently communicate with theOffice for Student Success and offices of undergraduate research at peer institutions. Another item in their interest is to develop zero credit hour courses related to research methods and ethics for students not enrolled in the Honors College. The co-directors will also work with research administration staff in the tracking and tracing of funding and expenditures which support research activities at the undergraduate level.

With theI3R Initiative on the horizon, there is an enormous opportunity for expanding undergraduate research at the UofA. The new co-directors of undergraduate research are excited to continue sparking innovation and encouraging collaboration among the student body.

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Servoss and Thallapuranam to Jointly Serve as Co-Directors of Undergraduate Research - University of Arkansas Newswire

Safeguard to Prevent Passengers from Catching Infectious Diseases – Healthcare Tech Outlook

A new anti-microbial film has been launched in the UK that can remove 99.9% of deadly infectious diseases like E.coli and MRSA.

FREMONT, CA: The COVID-19 pandemic has made the situation crucial due to which the aviation industry is also trying to apply severe cleaning measures so that it can protect its passengers and employees. During such critical condition, a new anti-microbial film has been launched in the UK that can remove 99.9 percent of deadly infectious diseases like E.coli and MRSA according to biochemical tests conducted by BioLabs.

As per GlobeAir, around 700 touchpoints are endangering passengers to the risk of getting contaminated on a single commercial flight. According to Protective Film Solutions, the distributor and installer of the SafeTouch film, the airports and airlines which has high-traffic areas typically and numerous touchpoints like screens, handrails, and handles must install the clear film. Such films are made from over 60 percent anti-microbial copper to eradicate deadly germs.

The pioneering film that is presently being trialed by one of the prominent supermarket chains has been tested and certified by biochemistry laboratory BioLabs. It has confirmed that the product can kill 99.86 percent of Escherichia coli and 99.85 percent of MRSA. Therefore, the tests on its ability to slow down the spread of COVID-19 will start when permission for non-vaccine trials are given.

Chris Gould, Commercial Director of Protective Film Solutions, commented, following the impact of COVID-19, we all expect businesses and public sector professionals to treat hygiene with the utmost importance for the sake of public health.

SafeTouch is undoubtedly a game-changing solution for airports and airlines, and indeed almost any industry looking to reduce transmission of respiratory viruses be it for patients, customers or employees. We are pleased to be able to bring the film to the UK market and hope to see it adopted by those with high turnovers of people such as retailers, fast food outlets, medical centres and the aviation industry.

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Safeguard to Prevent Passengers from Catching Infectious Diseases - Healthcare Tech Outlook

Scientists discover genetic and immunologic underpinnings of some cases of severe COVID-19 – National Institutes of Health

Media Advisory

Thursday, September 24, 2020

New findings by scientists at the National Institutes of Health and their collaborators help explain why some people with COVID-19 develop severe disease. The findings also may provide the first molecular explanation for why more men than women die from COVID-19.

The researchers found that more than 10% of people who develop severe COVID-19 have misguided antibodiesautoantibodiesthat attack the immune system rather than the virus that causes the disease. Another 3.5% or more of people who develop severe COVID-19 carry a specific kind of genetic mutation that impacts immunity. Consequently, both groups lack effective immune responses that depend on type I interferon, a set of 17 proteins crucial for protecting cells and the body from viruses. Whether these proteins have been neutralized by autoantibodies orbecause of a faulty genewere produced in insufficient amounts or induced an inadequate antiviral response, their absence appears to be a commonality among a subgroup of people who suffer from life-threatening COVID-19 pneumonia.

These findings are the first published results from the COVID Human Genetic Effort, an international project spanning more than 50 genetic sequencing hubs and hundreds of hospitals. The effort is co-led by Helen Su, M.D., Ph.D., a senior investigator at the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH; and Jean-Laurent Casanova, M.D., Ph.D., head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University in New York. Major contributions were made by Luigi Notarangelo, M.D., chief of the NIAID Laboratory of Clinical Immunology and Microbiology (LCIM); Steven Holland, M.D., director of the NIAID Division of Intramural Research and senior investigator in the NIAID LCIM; clinicians and investigators in hospitals in the Italian cities of Brescia, Monza and Pavia, which were heavily hit by COVID-19; and researchers at the Uniformed Services University of the Health Sciences in Bethesda, Maryland.

The wide variation in the severity of disease caused by SARS-CoV-2, the virus behind COVID-19, has puzzled scientists and clinicians. SARS-CoV-2 can cause anything from a symptom-free infection to death, with many different outcomes in between. Since February 2020, Drs. Su and Casanova and their collaborators have enrolled thousands of COVID-19 patients to find out whether a genetic factor drives these disparate clinical outcomes.

The researchers discovered that among nearly 660 people with severe COVID-19, a significant number carried rare genetic variants in 13 genes known to be critical in the bodys defense against influenza virus, and more than 3.5% were completely missing a functioning gene. Further experiments showed that immune cells from those 3.5% did not produce any detectable type I interferons in response to SARS-CoV-2.

Examining nearly 1,000 patients with life-threatening COVID-19 pneumonia, the researchers also found that more than 10% had autoantibodies against interferons at the onset of their infection, and 95% of those patients were men. Biochemical experiments confirmed that the autoantibodies block the activity of interferon type I.

Q Zhang et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science DOI: 10.1126/science.abd4570 (2020).

P Bastard et al. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science DOI: 10.1126/science.abd4585 (2020).

NIAID Director Anthony S. Fauci, M.D., NIAID Senior Investigator Helen C. Su, M.D., Ph.D., and Luigi Notarangelo, M.D., chief of the NIAID Laboratory of Clinical Immunology and Microbiology, are available for interviews.

To schedule interviews, please contact NIAID Office of Communications, (301) 402-1663, NIAIDNews@niaid.nih.gov.

NIAID conducts and supports research at NIH, throughout the United States, and worldwide to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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Excerpt from:
Scientists discover genetic and immunologic underpinnings of some cases of severe COVID-19 - National Institutes of Health

Heres how you can control eczema and psoriasis flare-up during changing weather – The Indian Express

By: Lifestyle Desk | New Delhi | Updated: September 22, 2020 10:39:01 pmThe lesions usually occur on cooler places of the skin like the elbows, the knees, the scalp, on the palms, soles, etc. (Source: Pixabay)

The body reacts differently to the changing weather, and those who suffer from skin conditions would know that weather always factors in whenever there is a sudden deterioration of the condition.

Eczema (or dermatitis) is a condition wherein the patient develops severely-itchy lesions with fluid-filled vesicles/oozing during an acute exacerbation phase, and psoriasis is a skin disease wherein the turnover of the skin speeds up. Instead of the average two months, the skin turns over in three or four days, leading to red or pink lesions with silvery-white scaling. The lesions usually occur on cooler places of the skin like the elbows, the knees, the scalp, on the palms, soles, etc.

Dr Smriti Naswa Singh, Consultant Dermatologist, Fortis Hospital, Mulund, says the reason for developing eczema could be external (sun, aero-allergens, some irritant applications, etc.) or internal (familial allergic tendency, endogenous eczema, old age, or a manifestation of other internal diseases like diabetes, chronic liver or kidney disease, cancer, HIV, etc.). While psoriasis and eczema do not spread to others, they do flare up during winters or cooler seasons, since the dryness of the skin increases, leading to more itchiness; when a person scratches, the patches aggravate.

ALSO READ |Home-based care for COVID-19 infection; here are some dos and donts

Dr Singh suggest the following ways to control the outbursts:

* Change of weather to cooler weather makes the skin dry. Applying a moisturizer is key. Moisturizers work best on wet skin and have to be frequently applied throughout the day.

* Itch-scratch is a vicious cycle that needs to be broken to control the exacerbation. So whenever one feels itchy, they should apply moisturizer and not scratch the area. Oral and topical medications help in controlling the itching sensation; do consult a dermatologist for guidance.

* Weather-change is usually associated with an increase in aero-allergens, so those suffering from atopic dermatitis (eczema due to allergic tendency running in family) suffer more. They should try to keep their immunity high by consuming fruits and vegetables, taking adequate rest and staying away from common allergens like dust, sweat, synthetic clothes, wool etc. Cotton clothing is the preferred choice.

* Stress is known to exacerbate both psoriasis and eczema, and hence, should be avoided. Adequate rest and work-life balance are important factors.

ALSO READ |What patients on dialysis need to know about controlling diabetes

* Psoriasis is directly linked to metabolic syndrome. Psoriatic patients have a tendency to be more prone to lifestyle diseases like diabetes, hypertension and altered lipid profile. If the person indulges in oily foods, junk foods, gains weight, does not exercise, psoriasis can worsen. Adopting appropriate lifestyle measures will help in such scenarios.

* During the COVID-19 pandemic, people have been overzealous in washing hands and using hand sanitizers. Detergent strips off the skin from natural moisturizing factors for at least 6 hours before the skin replenishes it. Sanitizers can be irritant/allergic to sensitive skin. Refrain from excessive use of soaps/washing detergents/sanitizers. Applying a moisturizer after washing/cleaning your hands/feet will help prevent the aggravation.

A patient can prevent exacerbation of psoriasis and eczema by keeping in mind the aforementioned methods. But for treatment of the lesions, one needs a carefully-formulated, tailor-made prescription of oral/systemic and topical medications. You should visit your dermatologist at first instance of the flare-up, or when the rashes are noted; these can be treated with topical cream formulations alone.

ALSO READ |How do COVID-19 triggered blood clots affect the heart? A doctor answers

If unfortunately, there is delay and the disease becomes extensive, oral medications may be required and sometimes, especially in psoriasis and certain cases of endogenous eczemas, there may be a need for control of acute exacerbation. We call such cases as acute skin failure with risk of hypovolemia, infection, electrolyte imbalance and thermal dysregulation, Dr Singh explains.

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Heres how you can control eczema and psoriasis flare-up during changing weather - The Indian Express

Hopes of breakthrough for psoriatic arthritis patients after Sanger Institute and Oxford University discovery – Cambridge Independent

A third of patients with the skin condition psoriasis develop psoriatic arthritis, for which are some treatments but no cure.

The long-term condition, which causes affected joints to become swollen, stiff and painful, can worsen over time. In the worst cases, it can permanently damage joints, meaning surgery is required.

But there was new hope for those with the condition on Monday, when a study was published showing psoriatic arthritis may be activated by the same trigger in different patients.

The research by the Wellcome Sanger Institute and University of Oxford gives the strongest evidence yet of a single cause for the disease after identifying high levels of a specific receptor in immune cells from patients.

It could help scientists find the exact molecular trigger, which would raise hopes of finding a targeted treatment.

The researchers used single cell technology and machine learning to analyse thousands of individual immune cells from fluid drained from the knees of patients with psoriatic arthritis.

Dr Hussein Al-Mossawi, honorary research associate at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) at the University of Oxford, said: Our data suggest that psoriatic arthritis doesnt just appear out of nowhere. Each receptor is like a unique lock that recognises a molecular key and we discovered, that across the patients, they are recognising a common molecule.

This gives the first evidence that the T cells are seeing and reacting to the same molecule, which acts as a trigger for the disease. We dont know the exact culprit yet, but this is a great step forward in understanding the disease.

Dr Sam Behjati, group leader and Wellcome Trust intermediate clinical fellow at the Wellcome Sanger Institute , said: Our study produced the largest single cell dataset from psoriatic arthritis patients to date.

It is helping us to understand the intricate mechanisms behind psoriatic arthritis, including starting to unravel the signals that tell the T cells to cross over into the joint fluid.Imagine the cells as train passengerswith a ticket that tells them at which station to get off - the single cell data is allowing us to read that destination for each cell, and understand the signals.

Paul Bowness, professor of experimental rheumatology at NDORMS said: Our findings indicate that specific T cells are likely to be targeted to enter the joint, where they are triggered to expand, creating inflammation and causing psoriatic arthritis.

The next stage of research will be to find the key that is unlocking the disease in patients - from the signals that direct cells to the joint, to what then triggers them to expand. If we can understand these, we could move towards creating therapies that would prevent this, potentially providing a cure.

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Hopes of breakthrough for psoriatic arthritis patients after Sanger Institute and Oxford University discovery - Cambridge Independent

Greater Joint and Skin Improvement With Ixekizumab vs Adalimumab in Patients With Psoriatic Arthritis – Rheumatology Advisor

Among patients with psoriatic arthritis (PsA), ixekizumab may be superior to adalimumab in terms of joint and skin improvement, according to study results published in Annals of the Rheumatic Diseases.

Results of the SPIRIT head-to-head trial indicated that ixekizumab was superior to adalimumab with regard to the achievement of the American College of Rheumatology (ACR)50 and Psoriasis Area and Severity Index (PASI)100 responses at 24 weeks..

The 52-week, multicenter, phase 3b/4, open-label, randomized, blinded-assessor study (ClinicalTrials.gov Identifier: NCT03151551) aimed to investigate the efficacy and safety of ixekizumab compared with adalimumab in adults with PsA. Patients with inadequate response to conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and no previous exposure to biologic DMARDs were randomly assigned 1:1 to receive either ixekizumab or adalimumab. The primary outcome was superiority of ixekizumab to adalimumab according to ACR50 and PASI100 responses after 24 weeks. Prespecified outcomes after 52 weeks included musculoskeletal, psoriasis, quality of life outcomes, and safety.

The study cohort included 566 patients, of whom 283 received ixekizumab and 283 received adalimumab. Of the total cohort, 246 participants (87%) who received ixekizumab and 237 (84%) who received adalimumab completed the 52-week study visit.

At week 52, treatment with ixekizumab vs adalimumab was associated with a higher percentage of patients achieving both ACR50 and PASI100 (39.2% vs 26.1%, respectively; P <.001). Differences between the groups were evident after 8 weeks, and maintained throughout the study. A significantly higher percentage of patients who received ixekizumab achieved PASI100 (64.3% vs 41.3%, respectively; P .001). However, similar response rates for ACR50, ACR20, and ACR70 were observed with ixekizumab and adalimumab, as were other efficacy outcomes, including treat-to-target outcomes, enthesitis, and dactylitis resolution.

When used as monotherapy for 52 weeks, ixekizumab was superior to adalimumab for simultaneous achievement of ACR50 and PASI100 (38% vs 19%, respectively; P =.007), and PASI100 responses (66% vs 35%, respectively; P <.001). While response rates were higher with a combination of adalimumab and conventional synthetic DMARDs vs adalimumab monotherapy, response rates for ixekizumab were consistent irrespective of concomitant conventional synthetic DMARD use.

There were no new safety findings for either ixekizumab or adalimumab.

The study had several limitations, including the open-label design, potential assessment bias, and no available data on antidrug antibodies to ixekizumab or adalimumab.

SPIRIT-H2H study comparing ixekizumab [vs] adalimumab is the first fully disclosed direct head-to-head study in PsA; its findings over 52 weeks will inform future treatment recommendations and may impact selection of therapy in bionaive patients with active PsA, the researchers concluded.

Disclosure: This clinical trial was supported by Eli Lilly and Company. Please see the original reference for a full list of authors disclosures.

Reference

Smolen JS, Mease P, Tahir H, et al. Multicentre, randomised, open-label, parallel-group study evaluating the efficacy and safety of ixekizumab versus adalimumab in patients with psoriatic arthritis nave to biological disease-modifying antirheumatic drug: final results by week 52. Published online July 13, 2020. Ann Rheum Dis. doi:10.1136/annrheumdis-2020-217372

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Greater Joint and Skin Improvement With Ixekizumab vs Adalimumab in Patients With Psoriatic Arthritis - Rheumatology Advisor

Psoriasis Biologics and Heart Disease Risk – Everyday Health

People with psoriasis who are on biologic therapies may get an added boost to their overall health: a reduced risk of heart disease.

According to a study published in the September 2020 issue of the journal Circulation: Cardiovascular Imaging, people who received biologics like adalimumab and ustekinumab for one year to manage their psoriasis had lower levels of a type of coronary plaque called lipid-rich necrotic core (LRNC) compared with people who didnt receive the drugs.

LRNC has been linked with higher risk of heart attack and stroke in people with coronary artery disease.

The Centers for Disease Control and Prevention (CDC) describes plaque as cholesterol deposits that accumulate on the walls of arteries, causing blockages that can lead to coronary artery disease. Coronary artery disease is the most common form of heart disease in the United States, affecting an estimated 18 million people, the CDC says.

[Our] current hypothesis is that treatment of psoriasis may result in a lowering of the risk of cardiovascular disease over time, explains Joel M. Gelfand, MD, director of the Psoriasis and Phototherapy Treatment Center at University of Pennsylvanias Perelman School of Medicine Philadelphia, who was one of the coauthors of the new study.

RELATED: The Consumers Guide to Biologics for Psoriasis

It seems biologic therapy as well as phototherapy two commonly used treatments for psoriasis may both work to reduce levels of LRNC in the blood. LRNC is among several leading biomarkers (measurable signs) that can predict future heart attacks, Dr. Gelfand says.

Biologics, which target specific areas of the immune system, have been used for psoriasis treatment since the early 2000s. The biologics used to treat psoriatic disease block the action of a specific type of immune cell a T cell or proteins in the immune system, such as tumor necrosis factor-alpha (TNF-alpha), interleukin 17-A, or interleukins 12 and 23, according to the National Psoriasis Foundation.

TNF-alpha and the interleukins all play a major role in psoriasis and psoriatic arthritis.

RELATED: 7 Signs You May Need to Change Your Psoriasis Treatment

For the new study, Gelfand and his colleagues enrolled 209 people with psoriasis who had not yet been treated with biologics. Roughly one-half were prescribed biologic therapies to treat their condition, while the rest were not.

LRNC for people in both groups was assessed using coronary computed tomography angiography, with measurements taken at the beginning of the study and, again, one year later.

On average, those who received biologic therapy saw their LRNC decline from 3.12 square millimeters (mm2) to 2.97 mm2 or about 5 percent. Conversely, those who werent on biologic therapy saw LRNC increase from 3.12 to 3.34 mm2, on average a 6 percent rise.

RELATED: 8 Health Conditions Linked to Psoriasis

Although larger studies are needed to confirm the positive effects of biologics on LRNC and heart disease risk, the findings are exciting, Gelfand says, because recent research suggeststhat people with psoriasis are at increased risk for heart disease.

And this risk is more clinically significant in those with more severe skin disease, Gelfand notes. People with psoriasis should be screened for traditional cardiovascular risk factors such as high blood pressure, diabetes, and high cholesterol, and they should adopt a heart-healthy lifestyle whether theyre on biologics or not.

RELATED: Psoriasis and Heart Disease: The Hidden Connection

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Psoriasis Biologics and Heart Disease Risk - Everyday Health

Psoriasis Treatment Market Size, Analytical Overview, Key Players, Growth Factors, Demand, Trends And Forecast to 2027 – The Daily Chronicle

Fort Collins, Colorado Reports Globe recently added the Psoriasis Treatment Market Research Report that provides a thorough investigation of the market scenario of the market size, share, demand, growth, trends, and forecast from 2020-2027. The report covers the impact analysis of the COVID-19 pandemic. COVID-19 pandemic has affected the export-import, demands, and trends of the industry and is expected to have some economic impact on the market. The report provides a comprehensive analysis of the impact of the pandemic on the overall industry and offers insights into a post-COVID-19 market scenario.

The report primarily mentions definitions, classifications, applications, and market overview of the Psoriasis Treatment industry. It also covers product portfolios, manufacturing processes, cost analysis, structures, and gross margin of the industry. It also provides a comprehensive analysis of the key competitors and their regional spread and market size.

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The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

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Additionally, the report is furnished by the advanced analytical data from SWOT analysis, Porters Five Forces Analysis, Feasibility Analysis, and Investment Return Analysis. The report also provides a detailed analysis of the mergers, consolidations, acquisitions, partnerships, and government deals. Along with this, an in-depth analysis of current and emerging trends, opportunities, threats, limitations, entry-level barriers, restraints and drivers, and estimated market growth throughout the forecast period are offered in the report.

Market Breakdown:

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Psoriasis Treatment Market Segmentation, By Type

Psoriasis Treatment Market Segmentation, By Applications

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The report provides additional analysis about the key geographical segments of the Psoriasis Treatment Market and provides analysis about their current and previous share. Current and emerging trends, challenges, opportunities, and other influencing factors are presented in the report.

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Psoriasis Treatment Market Size, Analytical Overview, Key Players, Growth Factors, Demand, Trends And Forecast to 2027 - The Daily Chronicle

Immune system may trigger anxiety in response to infection – Medical News Today

A new study in mice adds to the evidence suggesting that the immune system not only attacks invading pathogens but can also influence mood.

Over the past few years, scientists have discovered some intriguing links between immunity and the mind.

One of the immune signaling molecules, or cytokines, that mediates these links is called interleukin-17a (IL-17a).

IL-17a plays a role in psoriasis, which is an autoimmune skin condition, but it may also contribute to the depression that many people experience. Indeed, a study involving a mouse model of psoriasis found that IL-17a caused depression-like symptoms.

In humans, researchers have also linked the molecule to treatment resistant depression.

Research in mice has even implicated IL-17a in the development of autism.

The brain and the body are not as separate as people think, says Prof. Jonathan Kipnis, a neuroscientist at the Washington University School of Medicine in St Louis, MO.

While working at the University of Virginia School of Medicine in Charlottesville, Prof. Kipnis and colleagues found that IL-17a causes anxiety-like behavior in mice.

We are now looking into whether too much or too little of IL-17a could be linked to anxiety in people, says Prof. Kipnis.

The scientists have published the results of their mouse study in the journal Nature Immunology. Kalil Alves de Lima, a postdoctoral researcher who is also now at the University of Washington, led the research.

Immune cells called gamma-delta T cells produce IL-17a. The cells are present in the meninges, which are the membranes surrounding the brain and spinal cord.

To determine what effect IL-17a might have on behavior, the scientists studied mice whose gamma-delta T cells did not produce any IL-17a and mice who lacked the cells completely.

They put the mice through standard tests of memory, social behavior, foraging, and anxiety. The mice performed just as well as normal mice on all tests apart from two that measure anxiety levels.

In those tests, the mice who lacked gamma-delta T cells or did not produce any IL-17a were more likely to explore open areas. In the wild, this kind of behavior would put them at greater risk of being eaten by predators.

The researchers interpreted this as a sign of reduced anxiety in animals without IL-17a signaling in their central nervous system.

Next, the scientists investigated how the signal affects neurons in their brains. They found receptors for IL-17a on a type of stimulatory nerve cell called a glutamatergic neuron.

When they genetically manipulated the neurons to prevent them from making these receptors, the mice exhibited less anxiety-like behavior.

Previous animal research has revealed a multitude of possible links between bacteria living in the gut and behavior, including anxiety-like behaviors.

This connection is known as the gut-brain axis, and scientists have proposed the immune system as one possible way that messages pass between them.

To investigate the role of IL-17a in the gut-brain axis, Alves de Lima and colleagues injected the mice with lipopolysaccharide. This is a toxin that bacteria produce. It provokes a strong immune reaction.

In response to the injection, gamma-delta T cells in the meninges surrounding the animals brains produced more IL-17a.

In another experiment, when the researchers treated the mice with antibiotics to kill the bacteria in their guts, the animals produced less IL-17a.

Together, the results of these experiments suggest that the immune system has evolved not only to fight infection but also to adjust behavior to keep animals safe while they are in a weakened state.

Selecting special molecules to protect us immunologically and behaviorally at the same time is a smart way to protect against infection. This is a good example of how cytokines, which basically evolved to fight against pathogens, also are acting on the brain and modulating behavior.

Kalil Alves de Lima

The team is now investigating how gamma-delta T cells in the meninges surrounding the brain can detect the presence of bacteria elsewhere in the body.

The researchers are also looking into exactly how IL-17a signaling in the brain changes behavior.

In their paper, they conclude:

Our findings provide new insights into the neuroimmune interactions at the meningealbrain interface and support further research into new therapies for neuropsychiatric conditions.

Although the physiology of mice and humans is very similar, scientists need to carry out much more research to explore the possible links between the human immune system and mood.

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Immune system may trigger anxiety in response to infection - Medical News Today

The infrastructure of Kick Ecosystem – hackernoon.com

We launched KickICO in 2017 to create a safer means of raising capital for enterprises in the blockchain sector, and to open that safer new channel to a community of investors.

In its first two years, the KickICO platform had played a key role in helping over 35 startups to raise 800,000 ETH.

However, ICOs have vanished and IEOs have been labeled as scam right in the beginning since its non-transparent realization that various exchanges have implemented and did not make it fair and transparent like was described in our White Paper.

Anticipating this back in 2017, and clearly understanding that the ICOs that were done in such way will soon die out, we began to build not just another platform for fundraising, but a large ecosystem in which fundraising is just one core element of our broader vision for a new financial paradigm driven by mainstream use of digital assets.

The primary services and pioneering concepts at the heart ofKick Ecosystemcame about through necessity. The Initial Coin Offering model was broken, creating opportunities for rogue developers and providing zero transparency or protection for consumers.

We found no exchange using a better model, and so we created our own; The initial exchange offering (IEO) and auction-based initial coin offering (AIO). It was not just the sale models that needed fixing, but exchanges too. Many were using ICO and IEOs for their own benefit, to the detriment of all other market participants, so we decided to launch our own exchange,KickEX, which could lead the way in open, trustworthy token finance.

In developing the exchange infrastructure, it became obvious that many services could be developed for enterprise use or harnessed by other projects.KickID, for example, is used in WHIRL, and our subsidiary blockchain-powered crowdfunding platform is used for private individuals, not companies.

Until now, the fintech sector has consisted of myriad apps scattered across the cryptoverse, defined more by their poor user journeys and barriers to entry than their innovation and traction. There has been no single entry point into the world of fintech, which helps to explain the gap between rapid technological progress and adoption. No single platform exists that brings together every service that individuals and businesses need, that anyone can use. That is the Kick Ecosystem vision. Every service, made for all: Beginners, professionals, and everyone in between.

We believe a one-stop hub for cryptocurrency services will be the driving force in mainstream adoption, but also that individual products and services can be useful to traditional enterprises without dependency on mainstream adoption of cryptocurrencies.

Using Kick Ecosystem as the foundation, we are releasing autonomous global services that allow for interoperability to create an ambitious financial services network that far exceeds any current model.

By harnessing critical elements from P2P, B2B, and SaaS technologies, were able to design and implement a range of autonomous services that can function both independently and in synergy with each other as part of the ecosystem.

With unparalleled usability and integration at their core, our services can be applied to a virtually limitless range of commercial applications in non-crypto projects, from gaming to e-commerce and retail.

Every element within the Kick Ecosystem performs an important role in the exponential growth of users and partners.

KickEX is the primary entry point for new users including traders, investors and miners. Users are then able to access the fundraising platform and to other services and back. All services are linked to KickID the unified ID services, a B2B solution, which is offered to external business, that will become a part of our ecosystem.

KickID andKickWalletare the core tools which enable users to seamlessly navigate the network of products and services, while KickRef gives them a role in the organic scaling of our user base.

For commercial partners, the advantages and synergies of operating within the Kick Ecosystem are obvious. Businesses can transform their bottom lines, access a qualified consumer base and bring the benefits of Kick to their existing database of users.

Reliable implementation and the development of standards will be key to the success of Kick.

Each service is developed by a separate team with a single protocol, standards and API. Services are modular in design, with the ability to function as a stand-alone product and as part of the wider ecosystem. All Kick services are compatible with cryptocurrencies and digital assets, although they can be configured to operate with or without them.

Thanks to a single standard of communication between services and IPAs, the ecosystem can be easily expanded with other services that do not yet exist.

From the very beginning of exchange development, security and decentralization of user funds have been key priorities for us. We employ CISCO next-generation hardware firewalls, DELL server hardware stacks, geographically distributed data centers and cloud hosting services based on private networks with the latest generation of encryption.

We also use the most advanced and modern data access algorithms, and third-party detection and prevention mechanisms with updated real-time signatures of new types and methods of attack.

Security is further enhanced with proprietary, provider-level mitigation services for DDoS attacks, automatic start-of-the-attack protection mode if suspicious activity is detected and Trusted Platform Module systems that protect against physical access to servers.

These and many other security measures and technologies allow us to guarantee the clear and uninterrupted operation of all services and the safety of user funds.

Our fundamental strategy for the expansion of Kick Ecosystem is to design tools and services that solve the challenges we face ourselves. Thats how KickID andKickRefwere born.

That strategic vision flows through everything we do, from high-level roadmaps to each service and mechanic. This is the reason that the entire architecture of the Kik Ecosystem is built using a microservices model. Each service can function independently, which increases fault tolerance a problem in one part of the system does not affect other services and the chance to operate each service as a stand-alone project.

Our team mirrors our technology, with a large group of developers divided into smaller teams responsible for each product. Microservices communicate with each other through a common, unified communication protocol that allows us to make B2C products such as KickEX exchange and then evolve them for enterprise use.

Our strategy can be seen in the creation and evolution of the KickID and KickRef services. First, we created them for ourselves, debugged, optimized, and further understood what features were necessary for success. Now we are transforming these services into B2B products suitable for third-party use.

The evolution of microservices into independent B2B products expands the entire Kick Ecosystem exponentially. Each new user who registers via KickID or KickEX becomes part of our ecosystem, with the opportunity to utilise and easily switch between any services. Having registered and verified once, each users journey through the ecosystem will be seamless.

Our strategy is based on synergy, the snowball effect, and business virality. By implementing new parts of the ecosystem, new services, which will then be distributed by other companies, projects and businesses, we believe our technology and values can transform any sector for the good of every enterprise and its end users.

Each new member of the ecosystem will enjoy all the benefits that were created by members that came before them and create value for the community they join. Using these principles of leverage and synergy to drive our exponential growth strategy, we are creating right now, the connected digital world of tomorrow.

KickIDis an end-to-end authorization and authentication service that connects all of our services and enables full access to the Kick Ecosystem through registration and universal KYC verification. As well as being an essential component of Kick Ecosystem, KickID is also the perfect tool for businesses seeking access to a single database of users already registered in the ecosystem, or who need an effective stand-alone solution for registering and verifying their users.

KickID was designed to slash the cost of KYC by requiring users to be verified only once. As the ecosystem grows and more users install KickID, KYC overheads decrease further. Over time, that cost will drop to virtually zero, saving businesses who operate on Kick millions of dollars.

By removing the need for new customers to complete verification more than once, KickID optimises consumer user journeys and has the potential to dramatically increase conversion rates for all third-party businesses that have integrated KickID for themselves.

Access to a pool of active accredited consumers gives business not only a valuable new acquisition channel but also enables them to develop more competitive offers and reward programmes. Businesses who use KickID can also reduce or eliminate the time and cost involved in processing data, payments and verification while ensuring they meet all compliance obligations for their jurisdiction.

KickRefis a zero-cost multi-level marketing solution that can be used to drive quality traffic to almost any online product or service. In just 6 months and with no marketing budget, KickRef has proven its effectiveness by acquiring 1 million users with a genuine interest in KickEX.

KickRef uses a 10-level referral model that any online business can harness to create viral growth with minimal cost, effort, or risk.

By distributing a part of the companys profits proportionally throughout a users network of referrals, the KickRef model is perfectly suited to businesses such as online games, gambling, and e-commerce. Just as KickID is able to improve registration and conversion rates, KickRef can increase traffic, create an instant user base, improve average customer value and reduce churn.

Like every proven Kick product that is tested and optimised within our own Ecosystem first, KickRef can be customized to specific business requirements. Rewards can be configured to suit specific business models and audiences using real money, game points, bonuses, and other virtual items.

Affiliate programmes should be simple, quick, and effective tools for its user-evangelists. With built-in tools such as leagues, ratings, statistics, and messengers, KickRef is a powerful enterprise affiliate solution for promotion and growth.

TheKickEXdigital asset exchange is the core feature of Kick Ecosystem. With pioneering trading functionality, enhanced security, and innovative reward mechanisms, we are certain that believe our exchange can become the gold standard for cryptocurrency exchanges.

Most cryptocurrency exchanges suffer from a limited selection of order types: market order, limit order, and simple stop-order. As a result, traders have to use various third-party services and software to implement their strategies. KickEX smart orders such as trailing or double stops, chain orders, and others, allow users to automate their trading and maximise profits. These features also allow novices to trade professionally without the need to buy and master additional software tools, reducing the skill gap between beginners and professional traders.

Three years after the first initial coin offerings rewrote the rules of fundraising, token sales are still the primary means of fundraising for blockchain projects. But not all ICO platforms are equal. KickICO is a fundraising platform underpinned by a ready-made audience engaged by social features.

From the technology we use to the features weve provided and messaging across every, KickICO reflects the wider values of Kick Ecosystem. With such a high profile history of fraud and unethical behavior, its critical that fundraising is open, transparent, fair, and safe.

Launching a fundraising campaign is just the first step for blockchain projects. We empower projects to exceed their campaign goals with a complete toolkit which includes automated advertising capabilities to maximise reach with minimal effort.

KickICO has remained at the forefront of crypto fundraising with a pioneering Auction Initial Offering (AIO) fundraising model invented by the Kick team. Projects will soon have access to a new Security Token Offerings (STO) model too.

Campaigns launched via KickICO have greater potential thanks to integrations with KickEX exchange and other Kick services such as KickID. By allowing projects to conduct multi-platform token sales through KickICO, KickEX, and their own channels using a simple, secure widget, Kick Ecosystem offers blockchain projects the best possible chance of success.

We recognise that social fundraising is an increasingly important means of attracting investment and generating early demand for innovative technology. As a result, KickICO comes pre-loaded with widgets for forums, websites, and blogs, as well as integrations with KickRed referral marketing features which allow users to earn money by attracting backers to fundraising campaigns.

By connecting KickICO with KickEX and KickRef, we supply projects with an organic, free flow of verified users with a confirmed interest in emerging technologies that only the most expensive PR campaigns could achieve.

Together, the Kick Ecosystem tools make KickICO the most powerful, one-stop fundraising and marketing platform in crypto.

KickMessengeris an instant communication tool created for use with KickRef as well as, but now available for a wide range of B2B use cases.

Unlike other messenger applications that facilitate anonymity, KickMessenger requires users to be verified, although communications and content remain secure and private.

By integrating KickMessenger with the Kick Ecosystem, fraudulent or spam users can be identified and blocked throughout the network with a single click, reducing the impact and cost of criminal or unethical behavior.

We believe transparency and accountability are crucial to the long term success of Kick services and are also fundamental requirements for enterprise use. Unlike most messenger applications where illegal behavior is allowed by platform owners to flourish, KickMessenger does not support anonymity and ensures that users who breach the law or platform terms will be held accountable for their actions.

We made KikMessenger both for ourselves and for all projects who require a simple and easy-to-integrate messenger. Although originally designed for Kick Ecosystem users, we will release a stand-alone version of KickMessenger software which can be easily integrated with external B2C and B2B platforms.

KickWalletis our native solution which allows users to conveniently and safely store, send and spend their funds.

Users can easily store a range of digital assets, manage their portfolio, deposit, convert, and withdraw. The KickWallet roadmap includes support for credit and debit cards, and once released, gives users a single payment gateway for all businesses within the ecosystem, and enables businesses to quickly integrate a wallet solution into their applications.

Currently, KickWallet is a B2C service within the KickEX exchange, and fully functions as a custodian service. For B2B use, we are combining the technology behind KickWallet andKickMobile to offer a portfolio of funds and tokens, deposit and withdrawal of fiat funds, and simple and quick conversion of fiat and cryptocurrencies.

Depending on demand, we may also introduce a physical payment card linked to KickWallet.

KickAcquire is a planned crypto-enabled payment gateway for personal and enterprise use which allows users to deposit to, transact with and withdraw funds from cryptocurrency projects.

For crypto projects that cannot access traditional banking services, KickAcquire will give them the ability to accept payments and guarantee secure custody of funds.

Thanks to one-click integration with products and services as well as simple widgets, merchants can accept cryptocurrencies without the usual hassle or risk involved in creating their own infrastructures.

As with all Kick Ecosystem services, KickAcquire will also leverage the power of KickID to increase conversion, as many users will already be verified.

KickAcquire will be a B2B solution for enterprise use.

KickCPA is more than just a dedicated digital advertising tool for the cryptocurrency sector. As a means of reaching bigger audiences and rewarding acquisition in an honest and transparent way, KickCPA is a blessing for everyone in the cryptosphere.

Existing ad networks do not serve the needs of blockchain organisations and particularly fundraising projects. For crypto projects looking for initial investment, acquiring investors through digital marketing has become prohibitively expensive. And with some of the biggest ad networks, crypto marketing may not be possible at all.

Advertisers often end up paying for vanity metrics such as clicks and views and are at higher risk of fraud.

KickCPA solves these problems by enabling projects to raise funds through KickICO and pay only when leads convert from a visit to investment.

KickCPA also enables publishers, bloggers, and individuals with an online audience to generate revenue by serving ads that drive meaningful traffic to KickICO campaigns and result in backing.

Once it has proven its worth on KickICO, the technology behind KickCPA will be extended beyond KickICO fundraising to provide an independent advertising network that third-party businesses

We believe in empowering our users with both effective products and vital knowledge.KickAcademyis an online learning centre which covers all aspects of cryptocurrencies and trading. With tools such as our unique trailing stop constructor, inexperienced traders can accelerate their learning curve, understand how markets function and how to place orders without risking their own funds.

Our institute also publishes comprehensive and exclusive data about the latest academic research in the crypto markets, investments, exchanges, and fintech fields:

One in Two Crypto Users is a Referral ProgramStudy of the crypto community opinion and level of trust in stablecoinsResearch on the usage of orders on crypto-exchangesWhat is KYC and why the global crypto community needs user identification?

There are also educational articles for beginners and professional crypto traders to learn the basics oftechnicalandfundamental analysis, trading strategies,risk management,indicators, and other crypto trading professional tools. All the materials are available on the official academy website for free.

The studies made by KickAcademy team are being regularly published in top crypto media like DeCenter, Hackernoon, Coinspeaker.

After being credited to the clients exchange wallet, the cryptocurrency is transferred to the Mosaic Wallet to ensure reliable storage and eliminate the risk of cryptocurrency theft from the clients cryptocurrency wallet.

In Mosaic Wallet, cryptocurrency during its life-time is not stored in the same cryptocurrency wallet but moves between different cryptocurrency wallets at a certain frequency. At the same time, Mosaic Wallets, on which the cryptocurrency was already stored, do not participate in the further stages of the cryptocurrency life-cycle. The frequency of movement of cryptocurrency between Mosaic Wallets is set in the system settings. This approach can significantly reduce the risks of theft of clients money from the Mosaic Wallet cryptocurrency wallets.

In addition, various types of cryptocurrency wallets are installed within the Mosaic Wallet, depending on the maximum amount of cryptocurrency allowed to be stored in this wallet.

Thus, the risk is divided into different areas, such as R1, R2, R3. For example, the R1 wallet does not allow storing cryptocurrency in the equivalent of more than 100 USDT, the R2 wallet does not allow storing cryptocurrency in the equivalent of more than 1000 USDT, and the R3 wallet does not allow storing cryptocurrency in the equivalent of more than 10000 USDT. In case of the compromise of private keys for one of the wallets, the risk does not apply to the other wallets.

The cryptocurrency is stored on Mosaic Wallet until a command is received from the client to withdraw the cryptocurrency asset to an external wallet that does not belong to the exchange.

Mosaic Wallet private keys are not stored on electronic storage devices. When creating a private key, several responsible persons of the company receive one character string each, which is the basis for obtaining a private key. Thus, one employee of the company cannot single-handedly access the Mosaic Wallet cryptocurrency wallets. To gain access to the Mosaic Wallet cryptocurrency wallets, all responsible persons of the company must simultaneously enter all the strings of characters transferred to them for storage. This approach minimizes the risks of internal fraud and collusion of company employees.

To minimize operational risks associated with the unavailability of company employees and/or the loss of character strings handed over to them for storage the company introduces the roles of deputy responsible persons and duplicates of character strings required to obtain Mosaic Wallet private keys are stored in the safe deposit boxes or other secure offline data vaults.

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The infrastructure of Kick Ecosystem - hackernoon.com

This is the size of undisturbed ecosystems lost in 13 years – World Economic Forum

Between 2000 and 2013, Earth lost an area of undisturbed ecosystems roughly the size of Mexico.

That's the mind-melting finding of a new study published in One Earth and the researchers say it has "profound implications" for global biodiversity and for humans who rely on natural resources.

"We were expecting there to be high levels of intact ecosystem and wilderness loss, but the results were shocking," lead researcher Brooke Williams of the University of Queensland told The Guardian. "We found substantial area of intact ecosystems had been lost in just 13 years nearly two million square kilometres which is terrifying to think about. Our findings show that human pressure is extending ever further into the last ecologically intact and wilderness areas."

In total, the researchers found that 1.9 million square kilometers (approximately 700,000 square miles) of previously intact ecosystem area had been "highly modified" during the study period. They also found that 58.4 percent of Earth's land ecosystems were under "moderate or intense" pressure from human activity, while only 41.6 percent of ecosystems were intact and 25 percent were true wilderness.

The 1.9 million square kilometers lost were mostly tropical and subtropical grasslands in Asia, South America and Africa, according to the Wildlife Conservation Society (WCS), which participated in the research. The rainforests of Southeast Asia also suffered significant human encroachments.

The 1.9 million square kilometers lost were in Asia, South America and Africa.

Image: One Earth

To achieve these results, an international team of 17 scientists from six countries used satellite imagery to assess the human footprint on land-based ecosystems and how it had changed between 2000 and 2013, The Guardian explained. The researchers found that human pressure increased on nearly 20 percent of the globe and decreased on only around six percent.

"Data does not lie," senior author James Watson from WCS and the University of Queensland said in the WCS press release. "Humanity keeps on shrinking the amount of land that other species need to survive. In a time of rapid climate change, we need to proactively secure the last intact ecosystems on the planet, as these are critical in the fight to stop extinction and halt climate change."

The study comes amidst other dire news for wildlife and biodiversity. A UN study released last week found that world governments had failed to achieve any of the 20 targets they had set for preserving biodiversity by 2020. Another study published this month found that wildlife populations had plummeted 68 percent on average over the last 50 years.

Williams explained to WCS why the loss of intact ecosystems is such a big deal for humans and other animals.

"Intact lands are relied on by biodiversity for habitat, and by people for ecosystem services such as climate regulation and clean water," Williams said. "We continue to take these last functioning places for granted, and our results show urgent action is needed to protect those lands that do remain intact."

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This is the size of undisturbed ecosystems lost in 13 years - World Economic Forum

Humans Destroyed Intact Ecosystem Land the Size of Mexico in Just 13 Years – EcoWatch

Where would you go if, say, a flood devastated the city you live in? Millions of people around the world have been forced to answer this question. In 2017, 68.5 million people were displaced more than at any point in human history, according to the Brookings Institute. More than one-third of those were uprooted by sudden weather events, including floods, forest fires and intense storms. A 2018 report from the World Bank, which focused on three regions Sub-Saharan Africa, South Asia and Latin America found that without tangible climate action, more than 143 million people in just these three areas will be forced to move to escape the impacts of climate change by 2050.

But more than 1 billion people worldwide will live in countries with insufficient infrastructure to withstand climate change by 2050. The Pacific Islands are expected to be affected especially hard. Sea level there is already rising at almost 0.5 inches per year. Eight islands have already been submerged and two more are close to vanishing. By the year 2100, experts fear 48 more islands in the Pacific will be completely underwater.

So what about the people who live there? What do we call these people who will be displaced? It's actually complicated. It's difficult to determine what category these migrants should fall under because no global definition exists. Why does that matter? Without a standard method of classification, there's no way to track how many people are affected or displaced by an environmental or climate event. So the most commonly used term is "environmental refugee."

Experts credit the term and its definition to UN Environment Program (UNEP) researcher Essam El-Hinnawi, who in 1985 wrote the United Nations report titled "Environmental Refugees." El-Hinnawi defined environmental refugees as:

... those people who have been forced to leave their traditional habitat, temporarily or permanently, because of a marked environmental disruption (natural and/or triggered by people) that jeopardized their existence and/or seriously affected the quality of their life.

This working definition has been the baseline for current debate.

But according to the 1951 Geneva Refugee Convention, a refugee "is someone who is unable or unwilling to return to their country of origin owing to a well-founded fear of being persecuted for reasons of race, religion, nationality, membership of a particular social group, or political opinion" [source: United Nations High Commissioner for Refugees]. Environmental refugees do not legally fall under this status.

Why environmental refugees flee their homes is a complicated mixture of environmental degradation and desperate socioeconomic conditions. People leave their homes when their livelihoods and safety are jeopardized. What effects of climate change put them in jeopardy? Climate change triggers, among other problems, desertification and drought, deforestation, land degradation, rising sea levels, floods, more frequent and more extreme storms, earthquakes, volcanoes, food insecurity and famine.

The September 2020 Ecological Threat Register Report, by the Institute for Economics & Peace, predicts the hardest hit populations will be:

  • Sub-Saharan Africa, South Asia, the Middle East and North Africa
  • Afghanistan, Syria, Iraq, Chad, India and Pakistan (which are among the world's least peaceful countries)
  • Pakistan, Ethiopia and Iran are most at risk for mass displacements
  • Haiti faces the highest risk of all countries in Central America and the Caribbean
  • India and China will be among countries experiencing high or extreme water stress

The report also suggests that developed countries like the United States and regions like Europe are not immune. "The European refugee crisis in the wake of wars in Syria and Iraq in 2015 saw 2 million people flee to Europe and highlights the link between rapid population shifts with political turbulence and social unrest." Developed countries including Sweden, Norway, Ireland face little to no threat, the report found.

Climate change does not impact all people and all parts of the world in the same way. While floods ravage some areas, deserts are spreading in others. Desertification and depleted resources, including shortages of water and fertile land, are long-term consequences of climate change. But one of the biggest threats will be food insecurity.

"Ecological threats and climate change pose serious challenges to global peacefulness," Steve Killelea, founder and executive chairman of the Institute for Economics and Peace said in the in the 2020 Ecological Threat Report. "Over the next 30 years, lack of access to food and water will only increase without urgent global cooperation. In the absence of action civil unrest, riots and conflict will most likely increase. COVID-19 is already exposing gaps in the global food chain."

The report suggests global demand for food will increase by 50 percent by 2050. That means if there's no increase in food supply, many people could starve or be forced to flee in search of food. Currently, more than 2 billion people around the world are already food insecure.

When faced with the decision to flee, most people want to stay in their own country or region. Leaving a country requires money and could mean leaving behind family; simply relocating from a rural to urban area in search of work and resources may be easier. Plus, the chance to return and resettle back home is unlikely if a family leaves their country entirely. In instances when an area is temporarily inhabitable, like after a destructive hurricane, returning home may be an option. But when coastlines or entire islands are underwater, the possibility of going home is out of the question.

The future impacts of climate change will disproportionately affect the world's poorest but will also pressure countries around the globe through mass migration of refugees. Adaptation and resilience will be the key to reducing displacement risk both temporary and permanent in the forms of early warning systems and flood-defense infrastructure, sustainable agriculture and drought-resistant crops, as well as other protections.

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Humans Destroyed Intact Ecosystem Land the Size of Mexico in Just 13 Years - EcoWatch

maurices Partners with TCS to Build Greenfield IT Ecosystem for its Growth and Transformation – PRNewswire

SAINT PAUL, Minn. andMUMBAI, Sept. 24, 2020 /PRNewswire/ --Tata Consultancy Services (TCS) (BSE: 532540, NSE: TCS), a leading global IT services, consulting, and business solutions organization, has partnered with maurices, a women's fashion-apparel retail chain in the US and Canada, to help create a new flexible and scalable IT landscape for the latter.

Followingits journey as a standalone organization, maurices selected TCS as its digital transformation partner to help build its greenfield IT ecosystem that will optimize more than 200 existing applications and software components in the next 17 months of their transformational journey. TCS will help maurices strategize, create and operationalize the new scalable, secure and future-proof architecture for the underlying IT infrastructure, security layer, and a new application stack, as well as remediate its technical debt. Leveraging TCS' Machine First Delivery Model, powered by ignio, its cognitive automation software,maurices' technology transformation will drive synergy across the enterprise, integrating business, operations and IT teams without disruption to existing services.

In addition, TCS will help maurices build a brand-new data analytics platform with extensive reporting features. The project will also involve a refreshed, upgraded ecommerce platform that will facilitate quicker business decisions and faster go-to-market responses to industry or fashion trends.

"We are creating a greenfield IT and Infrastructure that will lay the foundation for the growth of maurices' business and operations. TCS being the industry leader has been chosen as our SI partner to implement the Project Split Rock, the initiative to standup the IT Ecosystem. We look forward to leverage TCS' Partnership Skills, Tools, Processes, Practices and Thought Leadership to ensure the success of Project Split Rock," saidFred Argir, Chief Information Officer & Chief Digital Officer, maurices.

"We are delighted to partner with maurices as they embark on their IT ecosystem transformation. The new resilient, agile, and scalable platform, powered by MFDM and ignio, will help them accelerate innovation, improve customer experience, build competitive differentiation, and fuel future growth," said PC Thomas, Head of Retail, North America S&W, TCS. "We look forward to building a long-term, trusted relationship with maurices."

TCS is utilizing its pioneering Secure Borderless Workspaces, a transformative operating model that allows organizations to fully and seamlessly transition to virtual workspaces, to enable a remote program kick-off from multiple locations.

About Tata Consultancy Services Ltd. (TCS)

Tata Consultancy Services is an IT services, consulting and business solutions organization that has been partnering with many of the world's largest businesses in their transformation journeys for over 50 years. TCS offers a consulting-led, cognitive powered, integrated portfolio of business, technology and engineering services and solutions. This is delivered through its unique Location Independent AgileTM delivery model, recognized as a benchmark of excellence in software development.

A part of the Tata group, India's largest multinational business group, TCS has over 443,000 of the world's best-trained consultants in 46 countries. The company generated consolidated revenues of US $22 billion in the fiscal year ended March 31, 2020, and is listed on the BSE (formerly Bombay Stock Exchange) and the NSE (National Stock Exchange) in India. TCS' proactive stance on climate change and award-winning work with communities across the world have earned it a place in leading sustainability indices such as the Dow Jones Sustainability Index (DJSI), MSCI Global Sustainability Index and the FTSE4Good Emerging Index. For more information, visit us at http://www.tcs.com.

For TCS global news, follow@TCS_News.

About maurices

Maurices is a women's specialty apparel retailer that celebrates feel good fashion for real life.

Maurices is committed to its service with stylepromise and offering affordable fashions that take women from workday to weekend, and all of life's adventures in between. With inclusive sizing from 0-24, maurices is famous for its versatile styles including key categories such as denim, dresses, tops and more. Established in 1931, maurices operates 916 stores in communities across the U.S. and Canada and offers even more fashion at maurices.com. maurices is headquartered in Duluth, Minnesota.

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maurices Partners with TCS to Build Greenfield IT Ecosystem for its Growth and Transformation - PRNewswire

Helping the UN Guide Ecosystem Restoration Into the Mainstream – CSRwire.com

WSP USA is a key participant in the United Nations Decade on Ecosystem Restoration, a major global initiative to bring awareness to the fight against climate change.

Sep. 22 /CSRwire/ - When the United Nations General Assembly declared 20212030 as the Decade on Ecosystem Restoration, it did so with an objective of taking a leadership role to find nature-based solutions to restore vital ecosystems around the globe.

The UN Decade on Ecosystem Restoration aims to massively scale up the restoration of degraded and destroyed ecosystems as a proven measure to fight the climate crisis and enhance food security, water supply and biodiversity. It is targeting widespread engagement with governments, UN agencies, international non-government organizations, academia and large corporations.

This initiative moves ecosystem restoration from a fringe movement to an essential response necessary to protect our global food and water supply and help change the trajectory of climate change, said Jennifer Brunton, WSP USA national practice lead for ecosystem restoration.

For its part, WSP provided feedback for the strategy report,United Nations Decade on Ecosystem Restoration 2021-2030 - Strategy for the Decade.

As identified in the report, The global public is largely unaware of the extent to which ecosystem degradation is impacting the well-being and livelihoods of billions of people, the costs of this degradation, and the profound benefits that would accrue with major investments in ecosystem restoration.

At the end of the decade, my hope is that the political support and public will is behind the scale of restoration needed, Brunton said. Policies, regulations, and legislation are changed to promote smart growth and habitat protection/restoration, and the financial mechanisms for supporting ecosystem restoration are in place.

Key Objectives

The UN Decade on Ecosystem Restoration has set several key objectives. The effort aims to:

showcase successful government-led and private initiatives to halt ecosystem degradation, restore those ecosystems that have already been degraded;

enhance knowledge exchange on what works and why (policy, economics and biophysical aspects), and how to implement restoration at scale;

connect initiatives working in the same landscape, region, or topic, to increase efficiency and impact;

create links between ecosystem restoration opportunities and initiatives with businesses interested in building a solid portfolio of sustainable production and impact investment; and

bring a wider spectrum of actors on board, especially from sectors that are not traditionally involved, by demonstrating the importance of ecosystem restoration to conservation as well as generation of social and economic benefits.

I have seen the transformation that can happen when ecosystem restoration projects are implemented, Brunton said. Its a powerful thing to witness a barren landscape change into lush breeding and foraging grounds supporting a diverse array of species. It can be done.

The UN initiative is raising the understanding that widespread improvements on a local scale will have a profound impact on the global environment.

Our ecosystems are connected in a complex web, and that includes us humans, Brunton said. The fish we buy at the market may breed in marshes, rivers, or streams but spend their adult life migrating in the open ocean. This results in an interconnectedness between us as individuals and habitats that extend well beyond our borders.

She added that the UN initiative aims at articulating these links to target shifts in culture and political/economic drivers so the act of restoring habitat is part of a broader initiative and ecological restoration is mainstreamed. Brunton stressed that there must be complete ownership of responsibility for the environment, even when it is not in our own backyard.

For example, the destruction of rainforests do affect us through this network; it is not some far way problem for someone else, Brunton said. The products we buy connect us to these degradations. For example, the fruit we buy at the store may be grown in fields developed from clearing the rainforest.

Environmental Partnerships

Currently, the UN lacks the technical capacity to implement a strategy to address the scale of restoration needed on its own and is looking to corporate partners like WSP to help guide its successful development.

WSP has over three decades of experience restoring habitats, which has culminated in over 10,000 acres of restored habitats, Brunton said. We have one of the largest benches of restoration experts in any organization. Pairing our technical strength both by numbers and range of expertise we have with our global reach makes our firm an ideal partner for this initiative.

WSP has been involved in several ecological restoration projects that exemplify the goals of the UN Decade on Ecosystem Restoration initiative, including:

Higbee Beach Tidal Wetland Restoration The restoration of several hundred acres of marsh into a greenway near Cape May, New Jersey is providing habitat for migratory species, and supports maritime and early successional forest, as well as a public access network. WSPs restoration design is grounded in science and supported by extensive baseline studies, including hydrodynamic modeling, extensive sediment sampling, and detail threatened and endangered species surveys.

Saw Mill Creek Wetland Mitigation Bank A 68-acre wetlands area on Staten Island has been threatened by flooding, invasive weeds and illegal dumping for years, and suffered severe degradation following Superstorm Sandy in 2012. To turn the tide, the New York City Economic Development Corporation selected WSP to provide wetland restoration for New York Citys first wetland mitigation bank.

Comprehensive Everglades Restoration Plan WSP is providing the South Florida Water Management District with scientists, engineers and restoration specialists to protect the water supply and control flooding in the region by preventing saltwater intrusion, encouraging responsible agriculture and urban development, and preserving fish and wildlife habitat in the Everglades.

Lincoln Park Wetlands Restoration A large tidal marsh was designed by WSP to fit into the natural landscape adjacent to Lincoln Park in Jersey City, which had become a landfill without a permit. Today the wetlands, streams and salt marshes, once blighted with debris, are now restored with 42 acres of tidal habitats, new inter-tidal channels, and public walking trails.

Wisconsin Point Dune Restoration A three-mile-long natural sand spit along Lake Superior, part of one of the longest freshwater sandbars in the world and a popular recreation area, had become degraded by excessive heavy foot traffic and activity, destabilizing the shoreline. WSP provided environmental and resilient design services to restore and stabilize 48,000 square feet of sand dune habitat.

Future Generations

The work carried out today will leave a legacy for future generations, and Brunton believes that this initiative is one way to establish tangible positive impacts in our own generation.

We have the understanding of the negative impacts of habitat degradation on climate change, food security, and biodiversity; and we also know the substantial benefits gained from uplifting degraded habitat to high functioning systems, Brunton said. What we have not done effectively is integrate these facts into the political and economic engines that are driving protection and restoration of habitat. This initiative aims to infuse a respect for habitat health into the global culture.

She believes it is possible to map ways for development to progress in balance with the global health.

We have not run out of time to repair the imprint we have left on the earths landscape, Brunton said. It will require slicing the problem from many angles economic, political, cultural. The UN is the one entity infused globally whose network and influence can forge the change needed.

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Helping the UN Guide Ecosystem Restoration Into the Mainstream - CSRwire.com

Don’t eat the rainforests: Top brands complicit in Indonesia’s ecosystem destruction, probe alleges – Down To Earth Magazine

Companies procuring oil from and financing the Royal Golden Eagle, which set up palm oil and pulp plantations in Indonesia, finds investigation

Palm oil is the go-to-product for food companies trying to meet the zero transfats limit in their products. But this shift has implications for the rainforests in Indonesia from where most companies source this oil.

An investigation by global watchdog Rainforest Action Network (RAN) has shown that food and cosmetic companies as well as financial institutions have links with companies implicated in the destruction of the Leuser Ecosystem, a forest area on the island of Sumatra, Indonesia.

This rainforest is said to be the only place left on Earth where tigers, orangutans, elephants and rhinos still coexist in the wild.

The investigationclaimed the following companies for procured oil from and financed the Royal Golden Eagle (RGE) group, which has established the destructive oil palm and pulp plantations in the area through subsidiary companies.

RGE, for example, procures palm oil from a mill supplied by PT Tualang Raya, a palm oil producer in the Leuser Ecosystem, the investigation claimed.

PTTualang Raya is also known to have cleared at least 60 hectares of lowland rainforest in the Leuser Ecosystem over the past six months. This is three times the rate of clearance in the last six months.

RAN investigation pointed out that many of these companies and banks had pledged to conserve the environment. For example, Kao, the Japanese Consumer Goods manufacturer, was the first company to adopt a No Deforestation, No Peatland and No Exploitation policy.

Similarly, MUFG and ABN AMRO, which were found to providefunds to RGE, are signatories to the United Nations Principles for Responsible Banking and have policies on financing sustainable palm oil.

These brands and banks must all suspend sourcing from, or joint-ventures and financing of, the Royal Golden Eagle group and all its subsidiaries and associated companies until the corporate group can prove its compliance with No Deforestation, No Peatland and No Exploitation benchmarks, said Gemma Tillack of RAN.

Palm oil is also detrimental to human health. As the world moves towards zero industrially produced transfat status in cooking mediums, palm oil has found favour because it is naturally saturated.

The adverse effects of palm oil are often contested, but a meta-analysis showed connection between palm oil consumption in 23 countries and mortality from ischaemic heart disease.

India is currently grappling with self-sufficiency in edible oil and has for long explored the possibility of plantations of palm oil. In 2019, the Andaman and Nicobar administration approached the Supreme Court to revoke a 16-year-old ban on monoculture plantations in the fragile ecosystem.

In 2014, Union minister and BJP leader Nitin Gadkari urged the authorities to consider oil palm because the hot and humid tropical climate of the island was suitable for its growth. But the idea was mooted again at the meeting on oil palm promotion policy held at the Prime Ministers Office on July 9, 2018.

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