GLOBAL MARKETS LIVE: Tech giants in the hot seat – Marketscreener.com

Apple launching new audio products? Apple has stopped marketing the wireless headphones and speakers of its rivals, including SONOS Bose and Logitech International, a sign that the apple company is preparing to launch new audio products, according to Bloomberg.

McAfees founder in jail. John McAfee, the McAfee software creator indicted for fraud in the United States, was in jail today pending extradition procedures after being arrested in Barcelona airport at the weekend, Reuters reports.

A thousand pieces? The report to be submitted this week by the antitrust committee of the U.S. House of Representatives concerning Amazon.com, Apple, Facebook and Alphabet contains "a thinly veiled call for the split" of these companies, according to corroborating rumors. Republican Congressman Ken Buck shares Democrats' fears about the omnipotence of these players, but does not believe that dismantling them is the answer.

Oil backlash. Exxon Mobil is going to cut 1600 jobs by the end of 2021 in Europe. This represents 11% of its workforce in the region. The company did not give details on the geographical distribution of the cuts.

Golden merger. Northern Star will buy Saracen Mineral in shares, for a valuation of approximately AUD 5.20 per share. The transaction creates the 8th largest player among gold mining companies.

In other news. Southwest Airlines offers its employees the opportunity to accept salary reductions in exchange for the absence of short-time work. BHP will buy an additional 28% interest in the Shenzi project, in the Gulf of Mexico, for $505 million from Hess Corp. Cisco will appeal a judgment that condemns it to pay $1.9 billion in a patent infringement case. Vontier will replace Noble Energy in the S&P500. K+S AG sells its US subsidiary to a consortium for $3.2 billion. Sonova will enter the Chinese hearing market. Dufry publishes the terms of its capital increase.

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GLOBAL MARKETS LIVE: Tech giants in the hot seat - Marketscreener.com

Cloud Computing Market Worth $760.98 Billion at 18.6% CAGR; Tech Giants Such as IBM and Microsoft to Focus on Introducing Advanced Cloud Solutions:…

Pune, Oct. 01, 2020 (GLOBE NEWSWIRE) -- The global cloud computing market size is projected to reach USD 760.98 billion by 2027, exhibiting a CAGR of 18.6% during the forecast period. Rising preference for omni-cloud systems will prove highly beneficial for the growth of this market, states Fortune Business Insights in its report, titled Cloud Computing Market Size, Share & Industry Analysis, By Type (Public Cloud, Private Cloud, Hybrid Cloud), By Service (Infrastructure as a Service (IaaS), Platform as a Service (PaaS), Software as a Service (SaaS)), By Industry (Banking, Financial Services, and Insurance (BFSI), IT and Telecommunications, Government, Consumer Goods and Retail, Healthcare, Manufacturing, Others (Energy and Utilities, Education, Media and Entertainment etc.)), and Regional Forecast, 2020-2027.

Omni-cloud computing is a cloud solution that allows multiple cloud services to smoothly integrate and streamline their data on a single platform. The omni-cloud system is being increasingly preferred over the multi-cloud system owing to its multiple advantages and leading the cloud computing market trends. For example, an omni-cloud tool makes possible accessing real-time information from any location. In a departmental store, for instance, whenever there is an inventory shortfall, the cloud will send notification to the authorities, who will then take the necessary action. Similarly, storage of data on a unified platform also enables efficient analysis, enhances productivity, and elevates the quality of services. These, along with a few other benefits, are widening the applicability of omni-cloud computing across a variety of industries.

The emergence of COVID-19 has brought the world to a standstill. We understand that this health crisis has brought an unprecedented impact on businesses across industries. However, this too shall pass. Rising support from governments and several companies can help in the fight against this highly contagious disease. There are some industries that are struggling and some are thriving. Overall, almost every sector is anticipated to be impacted by the pandemic.

We are taking continuous efforts to help your business sustain and grow during COVID-19 pandemics. Based on our experience and expertise, we will offer you an impact analysis of coronavirus outbreak across industries to help you prepare for the future.

Click here to get the short-term and long-term impact of COVID-19 on this Market.

Please visit: https://www.fortunebusinessinsights.com/enquiry/covid19-impact/cloud-computing-market-102697

According to the cloud computing market research report, the value of the market stood at USD 199.01 billion in 2019. The other highlights of the report are:

Market Restraint

Potential Risk of Cyber Attacks to Negatively Influence Adoption of Cloud Systems

Today, majority of organizations and many government departments and agencies have shifted their databases onto the cloud to improve efficiency and productivity of resources as well as bring down costs. Unfortunately, this move has exposed sensitive information to hackers, who have frequently launched cyber-attacks to retrieve and misuse data. For instance, the US-based Center for Strategic & International Studies (CSIS) revealed that in April 2020 hackers from Iran attempted to breach personal files of World Health Organization (WHO) staffers while the world was reeling under the coronavirus pandemic. In February 2020, two Chinese hackers were persecuted by the US Department of Justice for performing cryptocurrency laundering activities for North Korean nationals. Such attacks are prompted by the availability of delicate data on cloud platforms and the constant threat of privacy infringement may hinder the cloud computing market growth in the upcoming years.

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Regional Analysis

Strong Presence of Tech Bigwigs to Augment the Market in North America

North America is home to some of the biggest technology companies such as Google, Microsoft, and IBM and this factor has enabled the region to boast a market size of USD 61.59 billion in 2019. Moreover, the regulatory and research environment in the region is extremely favorable for development and adoption of advanced cloud technologies based on Artificial Intelligence (AI) and Machine Learning (ML). As a result, North America is slated to dominate the cloud computing market share during the forecast period. Increasing penetration of the internet and rising usage of smartphones will aid Asia-Pacific register a high CAGR, while rapid deployment of 5G will favor market growth in Latin America and Middle East & Africa.

Competitive Landscape

Advent of IoT to Create Numerous Innovation Opportunities for Market Players

The market leaders such as Oracle and SAP are directing their research and investment energies toward efficiently utilizing the opportunities generated by the Internet of Things (IoT) phenomenon. Most of the players in this market are focused of making their products and services smarter and more streamlined using IoT-based tools.

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Industry Developments:

List of Key Players Profiled in the Cloud Computing Market Report:

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Detailed Table of Content

TOC Continued...!!!

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Cloud Computing Market Worth $760.98 Billion at 18.6% CAGR; Tech Giants Such as IBM and Microsoft to Focus on Introducing Advanced Cloud Solutions:...

Which Scottish island would you put these asylum seekers on, Ms Patel? – The National

SOPriti Nasty Patel is thinking about using a Scottish island as a "holding pen"for asylum seekers coming to the UK?

The Jouker got to thinking what island she could have in mind, and since we have 900-plus islands off our shores and plenty more in our lochs, Priti Nasty has got a lot to choose from.

Purely as a service to the Queen of the Hostile Environment, heres a few islands we think she should visit before making her decision, if only to rule them out.

Lets start with the furthest out, namely Rockall. Wee problem here is the Republic of Ireland also claims this uninhabited and uninhabitable islet just 100ft (30m) wide and 70ft ( 21m) high. Probably not worth starting a fight with Dublin, so we can leave that off the list.

READ MORE: Alison Phipps:We must stand firm against cruelty of the Tory immigration system

St Kilda was inhabited for centuries until its few remaining residents famously left en masse in 1930. At least theres a military presence already there and we all know how much this Tory Government loves threatening to get the army involved in things.

Main trouble is that St Kilda is owned by the National Trust for Scotland and its former President Neil Oliver isnt around to fix it for his Unionist pals. Oh, and its a UNESCO World Heritage Site and we dont think the United Nations would be too happy to have the archipelago used to house asylum seekers.

If shes checking on the Outer Hebrides, Priti Nasty should be aware that certain localities are very hot on doing nothing but pray on a Sunday, so they couldnt provide the 24-7 service she is looking for.

Shetland has to be ruled out because if you believe the Unionist press, the islands want independence from Scotland never mind the UK, and at 6.5 miles across the Pentland Firth at its narrowest, Orkney is probably a bit too close to the mainland for the kind of people who have trekked thousands of miles and dinghied their way 20-odd miles across the English Channel.

READ MORE:Nicola Sturgeon slams Home Office plan to treat migrants like 'cattle'

Mull, Arran and Bute are full of the friendliest people imaginable and would be great hosts for asylum seekers, but those islanders are also just not prepared to be pushed around, so possibly best not to go there, Ms Patel.

The Bass Rock was often used as a prison over the centuries, and Hamish MacPherson will soon be telling its extraordinary story, and in any case, theres about 150,000 gannets on the island and they would love to dump a ton of guano on any Minister spoiling their peace.

So the message to Priti Nasty is this keep your holding pen well away from Scotland. In fact, theres a perfectly good isle not far from Westminster that would surely satisfy the Isle of Dogs. All those Tory bankers and meejah types on Canary Wharf will surely back the Home Secretary should she choose their backyard, wouldnt they?

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Which Scottish island would you put these asylum seekers on, Ms Patel? - The National

Get in the fall spirit when you stock up on $20 flannels from Uniqlo – Thehour.com

Men's and women's flannels, $19.90 at Uniqlo

Men's and women's flannels, $19.90 at Uniqlo

Photo: Uniqlo/Hearst Newspapers

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Get in the fall spirit when you stock up on $20 flannels from Uniqlo

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As I said last week, fall means flannel. It's an unwritten rule of the season that we all need to wear flannel, especially when headed to pick pumpkins and apples. It's an essential fall uniform. If you love flannel, you can get it for just under $20 at Uniqlo.

Normally $29.90, men's and women's flannel are marked down to $19.90. You can get a flannel shirt for every day of the week if that's the style you're looking to rock all fall. Check out some of the best styles on sale below:

WOMEN FLANNEL CHECKED LONG-SLEEVE SHIRT

WOMEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

Shirt in 44 Yellow

WOMEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

Shirt in 69 Navy

WOMEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

MEN FLANNEL CHECKED LONG-SLEEVE SHIRT

MEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

Shirt in 58 Dark Green

MEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

Shirt in 01 in Off White

MEN FLANNEL CHECKED LONG-SLEEVE SHIRT - uniqlo.com

Don't expect to find these prices in storesthe prices are online and in the app, only.

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Get in the fall spirit when you stock up on $20 flannels from Uniqlo - Thehour.com

Here’s a video of all the times GOP Senate candidate John James was caught in public not wearing a mask – Detroit Metro Times

Sure, it doesn't help that even the Centers for Disease Control and Prevention and Dr. Anthony Fauci initially advised against widespread mask use, fearing a shortage for frontline workers. But experts now agree that wearing a mask helps stop the spread of the virus. Many leaders, including Michigan Gov. Gretchen Whitmer, have called for them to be worn in public, while many businesses won't let people enter without wearing one.

The Republicans have had a really hard time with this one, though, probably because President Donald Trump has for the most part refused to be seen wearing a mask. On Tuesday's debate, he even made fun of his rival Joe Biden for wearing one. On Friday, it was revealed that Trump was in the hospital for COVID-19. (Also on Friday, Biden doubled down on his support for wearing masks at a Grand Rapids campaign stop. "Its not about being a tough guy. Its about doing your part," he said.)

With the eyes now on Republicans to see if they will change their tune regarding COVID-19, WXYZ-TV asked Republican Senate nominee John James on Sunday if he always wears a mask. In the clip, James says he has "always done everything he can to protect folks who are vulnerable."

But that's not true, according to leaked photos shared by John James Revealed, a website run by the Michigan Democratic Party. The group posted a photo slideshow of every time James has been caught in public this year not wearing a mask, including appearances with Vice President Mike Pence and Trump lapdog Kid Rock, all set to "In the Hall of the Mountain King" for dramatic effect.

You can watch the video below.

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Here's a video of all the times GOP Senate candidate John James was caught in public not wearing a mask - Detroit Metro Times

Ohio State has a BOOMING recruiting weekend – Land-Grant Holy Land

Unless you were hiding under a rock all weekend long, you probably know by now that Ryan Day and the Ohio State Buckeyes football program locked up another class of 2021 verbal commitment when three-star offensive tackle and one-time University of Louisville pledge Zenuae Zen Michalski publicly shut down his recruitment once again.

Deciding to call Columbus his soon-to-be college home over the Cardinals, Penn State, and Florida State, the 6-foot-6, 288-pound Indiana native gives Ohio State their 20th commitment of the 2021 cycle.

Committing to the Buckeyes via his Twitter page nearly a week after making a trip to Columbus to get more familiar with Ohio State University campus, Michalski didnt get to mingle with his now future coaches, but at the end of day saw enough to know it was the right spot for him on and off the gridiron.

I am going to be going to Ohio State, the future Buckeye told Rivals.com. I am a very young offensive lineman and I havent been playing the position that long. I want to go somewhere I can develop the best physically and technically. The coaches are amazing there, and I dont think Ive met a better group of people in this whole process. That was a big thing for me.

Currently looked at as the 48th offensive tackle, and 625th overall prospect in the entire senior class per the 247Sports Composite Rankings, Michalski might not be pegged as a five-star prospect, but has the potential to one day hear his name called in the NFL Draft. Just now growing into his frame and the position, hes put on over 60 pounds in the last year, turning him into one of the most sought after linemen in the Midwest this fall.

Using his new physic to help lead his Floyd Central High upfront, Zen is a key reason why the 5-2 Highlanders offense attack averages nearly 400 yards per contest this season.

Always looking for line depth on the recruiting trail, Michalski is the third offensive lineman to give Day and crew their word. He joins fellow big guys Donovan Jackson and Ben Christman in the Buckeyes class of 2021.

With all the excitement surrounding Michalski and what he brings to Ohio State, some of his future coaches and teammates took to their Twitter pages to personally welcome the offensive lineman to Buckeye Nation:

Originally posted here:

Ohio State has a BOOMING recruiting weekend - Land-Grant Holy Land

ZWALD For Polly Anna – We All Want Someone To Shout For

ZWALD - "For Polly Anna" - We All Want Someone To Shout For at We All Want Someone To Shout For

By Will Oliver, October 5th 2020 Other

ZWALD is the indie side project of lead singer and guitarist Jason Wade and Steve Stout of the band Lifehouse.They have returned with their brand new single For Polly Anna the first single and title track from our bands fourth LP in two years.

The track has an easy-breezy summery feel with a mix of some retro pop elements and classic rock, all made with a youthful shine that feels like a nice farewell to summer.

The band adds this description to the track, which you can stream below:

For Polly Anna is the first single and title track from our bands fourth LP in 2 years. The song is semi biographical from Jays past and echos some scenes of some family drama from a long time ago new fictional characters are introduced into the album as well.. so the album is loosely based on a true story with a through-line narrative. This is our first experiment in making a record in this way and were excited to share it with you.

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ZWALD For Polly Anna - We All Want Someone To Shout For

AC/DC Announces New Album ‘Power Up’ & Shares ‘Shot In The Dark’ Single – JamBase

Its offical, AC/DC confirmed the upcoming release of Power Up, their 17th studio album. Power Up is set to drop on November 13 via Columbia Records with the band previewing the 12-track LP by unveiling its lead single, Shot In The Dark.

The follow-up to 2014s Rock Or Bust features the latest incarnation of AC/DC with vocalist Brian Johnson, lead guitarist Angus Young, rhythm guitarist Stevie Young, drummer Phil Rudd and bassist Cliff Williams. Brendan OBrien produced the album, which was recorded at Warehouse Studio in Vancouver.

While co-founding member and Angus brother, Malcolm Young, died in 2017, Power Up contains songs based on riffs he wrote before he passed. It was pretty much written a while back, Angus said of Shot In The Dark to Ultimate Classic Rock. All of the tracks that weve got on the album were written by me and Malcolm. A lot of them were ideas we had that we knew were good AC/DC ideas at the time. But we just never got around to getting them on record.

Johnson, Rudd and Williams each left the band under different circumstances in the mid-2010s but have returned to the fold for the new LP. Power Up is available for pre-order in a variety of formats including a deluxe edition.

Stream Shot In The Dark below:

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AC/DC Announces New Album 'Power Up' & Shares 'Shot In The Dark' Single - JamBase

Baldur’s Gate 3 Early Access preview: A perfect playground to push Larian’s RPG to its narrative limits – GamesRadar+

Steam Early Access wasnt built for RPGs. The games that have thrived on Valves platform are mostly roguelikes and survival sims - experiences designed to be started and restarted. When these games are updated, theres no downside: the loop begins again, punctuated with new surprises.

RPGs, by contrast, tend to be long and persistent. Players agonise over their choices, knowing their ramifications could last well beyond what's currently on their screen. They carefully kit out their characters with complementary skills, laying the foundations for 100 hour marathons. In that context, a reset button is a nuclear event; the save game wipes that tend to plague Early Access anathema to the genre.

Or so I had always felt. Then Larian changed the dominant paradigm in RPGs - replacing the chat-and-fight formula of Mass Effect with something more experimental. Drawing on Ultima and the immersive sims of the 90s, the Belgian studio built volatile simulations in which any given situation could go a number of ways - depending on whether you engaged a guard in conversation, slipped the key from his belt, or coated him in oil and set fire to the whole joint.

The potential for systemic play is what makes Baldurs Gate 3 a vital game, even now in Early Access.

This potential for systemic play is what makes Baldurs Gate 3 a vital game, even now in Early Access. Its new public build may not be the most polished way to experience the first chapter of its story - but repeated runs of a reduced game encourage a more playful, exploratory approach to a genre in which players tend to just pick a path and stick to it.

Think of Metal Gear Solid 5: Ground Zeroes, or the episodic release of Hitmans levels. Though some players initially balked at their short length, many found that focusing on a single location made each game richer over time. The sensation of gradually mastering a space makes it one worth staying in - just as, if you stare at one patch of the night sky for long enough, it slowly reveals ever-more complex and marvellous networks of stars.

Baldurs Gate 3s Early Access build could hardly be called short - its 25 hours would be a respectable length for a finished RPG - but it settles on an unnamed stretch of the Sword Coast and leaves the Underdark-delving sprawl for Acts 2 and 3, which are at least a year away. As with Ground Zeroes and Hitmans Sapienza, the narrower space pushes you to go deep rather than broad. Larian rewards the attention with a knotted, layered environment.

My first bumpy landing on the beach - amid the wreckage of a Nautiloid, best imagined as a cross between a spaceship and a conch shell - fires me into the path of Shadowheart, a cleric who instantly challenges me to open a large wooden door set into the cliffside. Im a rogue, and so I do, making short work of the lock and leading our new party of two inside.

Im scarcely aware of having made a choice at all - until, hours of dungeon-crawling later, I happen back across the beach from a new vantage point, and realise Ive cut out first encounters with three other potential party members. In terms of navigation, Baldurs Gate 3 reminds me most of Dark Souls: a tangle of routes that curl back on themselves, like twisting vines (be wary of those - they do 1D6 piercing damage per turn).

An open world might not sound particularly groundbreaking, no matter how cleverly its threaded together. But your angle of approach can have a profound impact on combat and its outcome. When I emerged from the crypt Shadowheart had led me into, I looked up into the faces of four dug-in bandits. A dash across exposed ground ensued, followed by a desperate battle to even the odds.

If Id instead scaled the hill from the beach, I could have taken the crucial high ground, shoved the groups archer from his perch, and crushed two fighters beneath a falling rock - all practically simultaneously, thanks to the ability to trigger turn-based mode before a skirmish begins.

The fighting feels a tad more grounded than its Divinity: Original Sin equivalent. Though Dungeons & Dragons hasnt left Larian short on spells, and there are still many opportunities to combine the elements, the battlefield less regularly devolves into a boiling pool of electrified blood. Instead theres more focus on tactile pugilism - the hurled objects and desperate pushes with both hands that put distance between you and a marauding enemy.

Sneaking plays a surprisingly central role, too, since it unlocks more options for all-important positioning as hostilities open. With the addition of a mouse indicator that highlights whether youre about to move into light or shadow, plus illusions that pull the attention of enemies away from their usual patrol routes, Larian has the makings of a full-featured stealth engine on its hands. It seems feasible to avoid some encounters altogether, though I was loath to pass up the chance for elaborate backstabs, not to mention more XP. In D&D, for all its flexibility, personal development is still synonymous with killing.

Said killing often highlighted the bugs in the build I was playing, however. At the point of death, some enemies would warp horribly like John Carpenter monsters, their features unfolding across the terrain. One halflings hand merged with a nearby ladder, becoming a strange extra appendage for climbers to hold onto. Later, I saw a goblin thwack an archer so hard that he flattened into canvas, his body stretching like a tarpaulin that would have shielded the battlefield had it started raining.

These werent isolated cases: missing sound effects and jumpy animations abounded, and at one point a duplicate Shadowheart appeared just behind my companion; not unheard of in the Forgotten Realms, but in this case, not intentional.

Todays public build is already improved on the one I played yesterday, and Larian has been upfront about the number of bugs players can expect to face in Early Access. But its worth emphasising: though Baldurs Gate 3 might already have as much dialogue and as many distractions as a finished game, it certainly isnt one.

There will be some for whom the idea of an Early Access RPG feels intrinsically wrong - like racing the Nrburgring while its still being paved, or reading a series of epic fantasy novels before knowing whether the author will live to write the last one. Theres no arguing with the fact that, by playing Baldurs Gate 3 now, youre embarking on a journey you cant yet finish.

Yet theres something positive in that: the limited scope is an invitation to play - really play, to muck about and test the possibilities - rather than simply push to complete yet another RPG. This ones worth hanging around in.

Find some modern classics to keep you going while you wait for Baldur's Gate 3 in our list of thebest RPG games. And if you want to try the game that started it all, here's how to play D&D online.

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Baldur's Gate 3 Early Access preview: A perfect playground to push Larian's RPG to its narrative limits - GamesRadar+

High school golfers lose federal case over virus rules that kept them from D-10 tourney – GoErie.com

Ed Palattella|Erie Times-News

Four high school golfershave come up short of the legal pin in trying to sue their way into the boys District 10 championshiptournament in Meadville this week.

Their emergency motion, docketedin federal court in Erie on Thursday,claimed thatCOVID-19 restrictions that limitedthe number of the tournament's participants and kept each of the four boys from qualifying were unconstitutional.

In a ruling filed lateThursday night, U.S. District Judge Susan Paradise Baxter rejected the arguments of the golfers and their parents, who claimed thatthe Pennsylvania Interscholastic Athletic Associationand the District 10 Committeeviolated their civil rights by imposing the virus-related restrictions.

She said the PIAA and the D-10 Committee, which followed the PIAA's guidance,based the rules on medical advice, and that the restrictions were not "arbitrary and capricious," as the golfers and their parents contended.

"The Court will and should always err on the side of safety, which was the basis for the ruling by the PIAA to lower the numbers of golfers in the tournament," Baxter wrote in a 10-page opinion filed at 11:17 p.m. on Thursday.

"It is not the Courts job to decide the better course, but to ensure the one taken was not arbitrary and capricious, or for a wrongful purpose," Baxter wrote. "Although the decision was a painful one for the Plaintiffs, it was done with a rational basis and passes muster under the law."

The four boys and their parents asked Baxter to issue a preliminary injunction that would have prohibited the PIAA and the D-10 Committee from enforcing the restrictions. Such a ruling would have forced the D-10 Committee to add the four to thefield for the tournament for the boys, which startedFriday with first-round and team play at The Country Club ofMeadville. The D-10 tournament for the girls started on Thursday with first-round and team play.

The D-10 tournaments will conclude with the second and final individual rounds for both boys and girls on Saturday.

District 10 covers Erie County and the rest of northwestern Pennsylvania, Two of the four golfers whose familiessued are seniors at Conneaut Area High School, in Linesville, Crawford County,according to Baxter's ruling. The other twoattend Slippery Rock Area High School, in Butler County, where one is a junior and the other a senior.

Baxter's ruling and the other court records in the case identify the students only by their initials: A.M. and J.V. from Conneaut and L.W. and J.H. from Slippery Rock. All of the court records identify the students' parents by name, and several of theparents testified at a virtual hearing before Baxter on Thursday, according to her ruling. Baxter in her ruling identifiedthe parents who testified asJamie McKalip, Barbra Vaughn, Diana Wolakand Kevin Hadley.

The parents sued on behalf of their sons in Crawford County Court on Wednesday. The other plaintiffs were the Conneaut School District and the Slippery Rock Area School District.

The PIAA and the D-10 Committeewerethe defendants, and they transferredthe case to federal court in Erie on Thursday. They said the move wasappropriate because theplaintiffs claimed, among other things, that the students wereentitled to protection under the equal protection clause of the Fourteenth Amendment.

Baxter held the virtual hearing at 3:30 p.m. on Thursday, when she heard arguments from all sides for about 2 hours. She issued her ruling about five hours later, filing itbefore the boys D-10 tournament started on Friday.

The case is the latest example of litigation that has occurred across Pennsylvania to challenge restrictions that government authorities have issued to try to curb the spread of the novel coronavirus.

In another recent case, the 3rd U.S. Circuit Court of Appeals, based in Philadelphia, on Thursday stayed a federal district judge's decision that invalidated Gov. Tom Wolf's statewide limits on crowd size and other measures designed to combat COVID-19. The Circuit Court said the restrictions can remainin place as the court hears Wolf's appeal of the Sept. 14 ruling fromU.S. District Judge William Stickman IV in Pittsburgh.

Strickman and Baxter are colleagues on the federal bench for the Pittsburgh-based Western District of Pennsylvania, which includes U.S. District Court in Erie. Both Strickman and Baxter are appointees of President Donald Trump, though President Barack Obama first nominated Baxter and Trump renominated her.

In her ruling in the golfers' case, Baxter referred tothe hardships that the pandemic has created. But she said the PIAA and the D-10 committee acted properly under the law.

"The changes in the D-10 tournament rules that are at issue in this case have no doubt wrought genuine disappointment for the student athletes who were adversely affected by the change, as well as for their families," Baxter wrote."COVID-19 has affected all of our lives and normal dealings, and none more than students who have had their world turned upside down.

"Although the Court is grieved for the students and all they have lost this year, especially the four fine golfers who were dealt this blow just a week ago," Baxter wrote, "we all have to deal with the reality that nothing is the same as it was prior to this pandemic."

The PIAA on Sep. 23 approved reducing the number of golfers who could participate in the state championship tournament. The D-10 Committee the next day followed the PIAA's lead and reduced the number of golfers eligibleto participate in the D-10 championship tournament "and thereby compete for a berth in the state playoffs," Baxter wrote.

In previousD-10 boys championship golf tournaments, the D-10 Committee allowed eightplayers from Region 3, which includes Conneaut Area High School,and nineplayers from Region 2, which includes Slippery Rock AreaHigh School, Baxter wrote in her decision. The virus-related changes dropped the number of eligible Region 3 golfers in the boys D-10 tournament by four, to four golfers. The changes dropped the number of eligible Region 2 golfers by four, to five.

In their petition for a preliminary injunction, the plaintiffs argued that the reductions would"irreparablyharm" the golfers because their opportunity to play in the D-10 tournament"would be forever lost,"especially for the golfers who are seniors.

The plaintiffs' lawyers, Andrew Schmidt and George Joseph, of Erie, also questioned the efficacy of the COVID-19 rules that restrict the number of golfers. The "reduction in numbers has no quantifiable relationship on the spread of COVID-19 as it related to outdoor activities such as golf," they wrote in their petition.

In the PIAA's response, its lawyers Brian H. Simmons, of Pittsburgh, and Alan R. Boyton Jr., of Harrisburg wrote that the PIAA and D-10 Committee based their decisionson sound medical advice. Though the decisions are "certainly subject to review and second guessing," the lawyers wrote, the PIAA and D-10 Committee acted to achievea legitimate purpose.

"Here, the purpose was to reduce numbers of participants to make the spread of infection less likely," the lawyers wrote."The purpose and means of achieving it were both appropriate."

Contact Ed Palattella at epalattella@timesnews.com. Follow him on Twitter @ETNpalattella.

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High school golfers lose federal case over virus rules that kept them from D-10 tourney - GoErie.com

Black History Month: Are these the 10 most influential black musicians of all time? – Radio X

As Black History Month begins, Radio X takes a look at some of the most iconic black artists of all time and their influence on rock music. Does your favourite make the cut?

Today marks the beginning of Black History Month in the UK.

The annual event, which spans from 1-31 October each year, encourages us to recognise some of the outstanding contributions people of African and Caribbean descent have made to our lives.

Naturally, one of those contributions is music. Whether you look to the likes of Muddy Waters, Nina Simone or Jimi Hendrix, there are so many examples of trailblazers who continue to inspire and influence artists through the generations.

So who are some of the most influential and iconic black musicians of all time? Read our list and find out if your favourite artist makes the cut.

Remember: This list isn't exhaustive nor is it in order of preference, it's just an acknowledgement of some of the artists who changed the course of music history and who we have to thank for some of the biggest artists today.

McKinley Morganfield - known professionally as Muddy Waters - was a crucial figure in the post-war blues scene. The American blues singer-songwriter, who grew up on Stovall Plantation in Clarksdale Mississippi, began playing the guitar and Harmonica by the age of 17 and he was first recorded in the Library of Congress in 1941. After moving to Chicago to become a full-time musician, he recorded his first records for Columbia and Aristocrat Records in 1946.

Often cited as the godfather of modern Chicago blues, Muddy Waters and his band are known for their renditions of Hootchie Coochie Man, Baby Please Don't Go (which was covered by The Rolling Stones) I Just Want to Make Love to You and Got My Mojo Working.

Travelling to England in 1958, he laid the foundations for the resurgence of blues in the country and was a crucial influence on many of the legendary British bands we know and love today. The Rolling Stones named themselves after his 1950 song Rolling Stone, Led Zeppelin's Whole Lotta Love is based on the Muddy Waters hit You Need Love, Hoochie Coochie Man has had too many covers to mention and everyone from Eric Clapton to Jimi Hendrix cite him as influences.

St Louis-born Berry took rhythm and blues and made it palatable for white teenagers. Starting with Maybellene in 1955, Berry unleashed a string of hits that defined rock 'n' roll. Elvis covered his hit Johnny B. Goode, The Beatles covered Rock And Roll Music, The Rolling Stones' debut single was a cover of Berry's Come On.

Without Chuck Berry's ground breaking work, rock 'n' roll would't have been so big. And, let's not forget, one of the big moments in Pulp Fiction is John Travolta and Uma Thurmann dancing to Berry's You Never Can Tell.

Robert Nesta Marley (Bob Marley to me and you) considered to be one of the pioneers of reggae music. The Jamaican star - who fused elements of the genre with ska and rocksteady - stood out because of his blend of the musical styles and distinctive vocals and lyrics, which brought Jamaican music and culture to the masses.

Starting his professional career in 1963 after forming Bob Marley and The Wailers, they went on to release their debut album The Wailing Wailers in 1965, which featured the single One Love/People Get Ready. Other than being responsible of the enduring hits No Woman No Cry, Is This Love, Buffalo Soldier, Get Up Stand Up and I Shot The Sheriff, Marley is also considered as a Rastafari icon and was known for his unapologetic support for the legalisation of marijuana.

In 1977, Marley was diagnosed with cancer and sadly died as a result of it in 1981, aged just 36. However, he left a huge legacy behind - influencing a host of artists from across the musical spectrum and becoming one of the most instantly recognisable faces of all time.

The Godfather Of Soul. The Hardest Working Man In Show Business. Mr Dynamite. Whatever you call James Brown, you cannot deny his influence on 20th Century music. He was a huge R&B star in the 60s with songs like Papa's Got A Brand New Bag and I Got You (I Feel Good), but could still belt out a soulful ballad like It's A Man's Man's Man's World.

When civil rights leader Dr Martin Luther King Jr was assassinated in 1968, riots erupted in many US cities - and it was James Brown who publicly appealed for calm. He produced one of the key civilc rights songs of the era: Say It Loud, Im Black and Im Proud.

JB's commitment to the groove intensified as the 1970s arrived - Get Up (I Feel Like Being A) Sex Machine forged a new music in funk, where the riffs were relentless. Brown was surprised when some of his grooves began to be sampled by hip hop stars and beyond in the 80s.

The break from 1970's Funky Drummer was one of the most sampled recordings of all time, with Brown associate Bobby Byrd's cover of Hot Pants forming the backbone of The Stone Roses' Fools Gold.

Marvin Gaye - born Marvin Pentz Gay Jr. - helped shape the Motown sound of the 1960s, earning him the monikers, the Prince of Motown and the Prince of Soul. Known most for the likes of Let's Get It On, Heard It Through The Grapevine, and Sexual Healing, Gaye's songs continually get the cover treatment and his iconic 1971 What's Going On single - which was originally inspired by police brutality - has long been considered one of the most important songs of all time.

Shot dead by his own father on April 1 1984, the day before his 45th birthday, Marvin Gaye's life was senselessly cut short, but his impact on music and culture still remain today. In fact, Marvin Gaye is more relevant than ever, recently topping of Rolling Stone's 500 Greatest Albums of All Time with his What's Going On album, which knocked off The Beatles' Sgt. Pepper's Lonely Hearts Club Band to boot.

Francis Nicholls Jr - or Frankie Knuckles to his fans - may not have been a household name like some of the other musicians on this list, but his importance in the history of house music can't be ignored. A New Yorker by birth, he spent much of the 70s in the city, DJing at clubs with his friend Larry Levan. Together, they moved the genre on from disco to something more adventurous. When Knuckles moved to Chicago in 1977, he launched a club called The Warehouse, that began to play electronica and synth-pop. Aiming to boost some of his own remixes, Knuckles bought his own drum machine and the sound of The Warehouse became known as "House music" for short.

By '86, Knuckles was one of the most influential musicians on the planet, releasing the classic Your Love with Jamie Principle, later sampled by The Source featuring Candi Staton for You've Got The Love. His pioneering of house music led British bands like New Order and Pet Shop Boys to adopt the style, leading US DJs to take inspiration from them in turn. Frankie Knuckles died in 2014 aged 59, but his legacy lives on.

Nina Simone - born Eunice Kathleen Waymon - might be one of the hardest artists to pin down with her musical styles ranging from classical to folk, jazz, pop, gospel, jazz and blues. Born to a poor family in North Carolina and trained for a summer at Julliard, she might not seem like a rock star to you now, but the she lived every inch of her life like one. After adopting the name Nina Simone to in 1954 to stop her family discovering she was playing the "devil's music" she never looked back. Her enduring tracks include the likes of Ain't Got No, I Got Life, I Put a Spell on You, Don't Let Me Be Misunderstood, I Wish I Knew (How It Would Feel To Be Free) and Feeling Good, which gave Muse an unlikely hit in 2001.

However, to call Simone a singer-songwriter is only half her story. She was a hugely prominent figure during the civil rights era, where she spoke as well as performed. Simone's talent was as big as her troubled personal life, but her impact on music and culture has remained.

Artists to cite Nina Simone as an important musical influence include the likes of Aretha Franklin, David Bowie, Elton John, Bono, Lana Del Rey, Arctic Monkeys' Alex Turner, Jeff Buckley, Lauryn Hill, Matt Bellamy, Peter Gabriel and Adele. The list goes on and on...

James Marshall Hendrix was playing guitar from the age of 15 and after a brief spell in the US Army, wound up playing in backing bands for Little Richard and The Isley Brothers.

Moving to the UK in the mid-60s, he launched his power trio The Jimi Hendrix Experience and his unique technique of blues guitar and wild soloing quickly made him a superstar. With tracks like Purple Haze, Foxy Lady and Voodoo Chile, Hendrix took the electric guitar to whole new, often psychedelic levels.

He died in 1970, aged just 27, but every rock guitarist who ever threw a shape - from Prince to Matt Bellamy - is trying to capture some of that Hendrix magic.

Aretha Franklin's impact on the musical cannon cannot be understated. The Tennesee-born and Detroit-raised star, who started off as a church singer, brought her unique brand of soul to the masses. By the late 60s, songs such as Respect, (You Make Me Feel Like) A Natural Woman, Chain of Fools, Think and I Say a Little Prayer secured her status as one of the most prominent singers in US history and earned her the title of the Queen of Soul. But she didn't stop there.

Aretha used her voice and status for activism and she continued to record and release critically acclaimed albums such as Young Gifted and Black (1972) and Amazing Grace (1972) - while being known globally for her breathtaking performances and collaborations. Her rendition of Nessun dorma at the 1998 GRAMMY Awards (where she stood in for Pavarotti) remains one of the most iconic moments music award ceremony history. Aretha's impact on soul and R&B singers cannot be understated and everyone from Amy Winehouse to Adele (whose Rolling In The Deep song she herself covered) was heavily influenced by the icon.

If it wasn't enough to have left such indelible mark on our culture, Aretha lived through some of the most memorable moments in US history and performed at both the inaugurations of President Bill Clinton and President Barack Obama. Her death on 16 August 2018 prompted a tidal wave of tributes from all over the world and culminated in one of the most elaborate, star-studded funerals in music history.

When Prince Rogers Nelson signed his first record contract aged just 19, it was clear from the outset that he was a genius: the Minneapolis musician played every instrument on his debut album For You. Prince's music mixed 70s funk and the post-punk sounds of the New Wave, but his love for music was too great to be constrained by genres. If his musical talent wasn't enough to stop you in your tracks, then his image would. Prince didn't just defy genre, he also defend genders. Picking up from where Little Richard left off, Prince wasn't afraid to sport anything from fishnet stockings to suspenders and heels.

1999 was his big cross-over hit album - mixing in rock, pop, R&B and blues. MTV, who claimed they were a "rock" station and therefore couldn't play black artists, had to concede when Prince made Purple Rain - the album, the movie and the song that was the perhaps the biggest power ballad of the decade. From that point on, Prince released music in a dazzling array of styles, the highpoint of which was the ambitious double album Sign 'O' The Times in 1987. He died in 2016 aged just 57, but has left a huge vault unreleased recordings that proved the man genuinely loved making music.

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Black History Month: Are these the 10 most influential black musicians of all time? - Radio X

Digital Medicine And Remote Monitoring Receives Boost From New Playbook – Forbes

Digital medicine

A new Digital Measures Playbook was unveiled to help doctors and companies develop safe and effective clinical measures across patient care, research and public health. This is the latest multidisciplinary effort co-led by Elektra Labs and the Digital Medicine Society (DiME), a volunteer professional group created to drive scientific progress and broad acceptance of digital medicine to enhance public health in partnership with industry and academia.

The goal of The Playbook is to is provide an essential guide for successful remote monitoring across clinical research, clinical care, and public health. It is the result of collaborators from Genentech, a member of the Roche Group, Elektra Labs, Koneksa, Myokardia, Sage Bionetworks, Scripps Research as well as DiME. This first guide will be followed by an educational series, The PlaybookMasterclass, with interdisciplinary experts leading instructional sessions.

The value of remote patient monitoring dramatically increased with the COVID-19 pandemic as doctors need to closely track concerning symptoms such as worsening dyspnea from a distance. Physician scientists have called for digital systems that can provide vigilant evaluations of patients in the home for COVID-19 and also could be adapted to manage a variety of clinical conditions including hypertension, diabetes, or heart failure, where frequent human contact might be supplemented or partially replaced with digital automation and remote monitoring.

The current public health crises requires improvements in remotely monitoring and managing clinical research, routine care, and public health initiatives.The Playbookwill help address clinicians possible lack of experience implementing remote technologies by merging various frameworks for a 'how to' guide. Remote monitoring technologies are now advanced in their capabilities to detect symptoms of health and disease," said Jennifer Goldsack, executive director of DiME.

A critical benefit of remote monitoring using connected sensors is to offer a more holistic view of disease and lived experience by collecting important medical information continuously. The Playbookwill provide the foundational elements of developing and deploying high quality digital clinical measures that cut across use cases and positioning our field for a shared digital health data ecosystem, said Andy Coravos, CEO of Elektra Labs.

COVID-19 has been called an digital accelerant for remote monitoring while patients stay away from clinical settings. As research and care shift from hospital to home, there has been more adoption in the past few months in remote technologies. However, the need for sophisticated use of endpoints and digital data continues. For example, questions persist such as which digital clinical measures will best predict COVID-19 while patients are still pre-symptomatic.

Healthcare data

Efforts like the Playbook help address some concerning aspects of healthcare as costs continue to be unacceptably high coupled with with poor outcomes. Remote monitoring systems have the potential to shift this trend and be more patient-centered. Simultaneously, consumer technology giants such as Apple, Google Verily, Fitbit and Samsung have gotten clearances for personal monitoring devices, and are beginning to get broad adoption with the public, yet researchers and doctors need guidelines for how to use digital health data from remote devices.

Benchmarking digital clinical measures is an essential step in building confidence in how doctors interpret data from remote monitoring. The Playbook helps establish a roadmap for foundational processes in successful remote monitoring. Additionally different types of digital endpoints can be used in clinical trials, and to provide different levels of evidence about new medical product and interventions.

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Digital Medicine And Remote Monitoring Receives Boost From New Playbook - Forbes

Construction begins on new UW Medicine teaching facility in Spokane – Dailyuw

The UW-Gonzaga health partnership, UW School of Medicines Eastern Washington program, had been hoping for its own building since its establishment in 2016.

Right after we launched our partnership with them, we increased our class size by 20 students, Kim Blakeley, the UW Medicine director of communications for medical education, said. We were pretty packed.

The new medical education, health sciences, and innovation building which broke ground last week in Spokane will be the future home of 120 first- and second-year medical students, 30 to 35 MEDEX Northwest physician assistant (PA) program students, 225 human physiology students, and over 300 nursing and undergraduate health science students.

According to Blakeley, integrating so many disciplines of health science into one building allows for interprofessional proximity that encourages training across specialties.

It will give our medical students the opportunity to work more closely with nursing students, with PA students, Blakeley said. Theres also undergraduate health science students taking courses in the facility. It may interest a number of students in pursuing a career in medicine.

Previously, medical students had been renting the anatomy lab from Washington State University in Spokane. The upcoming four-story building will feature classrooms and labs, research space, administrative offices, and solar energy generation. It will also house a new anatomy lab to call its own.

The building is being built and managed by McKinstry, with UW Medicine and Gonzaga as the anchor tenants. McKinstry owns the Spokane & Inland Empire Railroad (SIERR) building next door, historically an electric streetcar repair station, which will be included in the new medical education hub and house MEDEX Northwest student classrooms.

The entire fourth floor of the new building will likely be dedicated to research and, according to Blakeley, other private industries related to health, wellness, and medicine.

Dedicating a 90,000-square foot building to health science education in Spokane reflects UW Medicines commitment to training physicians to practice in rural areas. Each of the WWAMI states (Washington, Wyoming, Alaska, Montana, Idaho) have UW Medicine campuses partnered with a local university that train residents and coordinate clerkship rotations among all five states once students reach their third year.

When they graduate, they all have UW School of Medicine diplomas, and the curriculum is the same throughout the region, Blakeley said. The opportunity to travel around, its a really unique system.

The interest in rural medicine appears to be increasing among new generations of medical schools. According to Blakeley, when UW Medicine first began in Pullman nearly 50 years ago, students who intended to attend the Seattle campus would say they had been WWAMI-ed to Spokane when the school placed them there instead.

Now that has flipped around, Blakeley said. All of the students in Spokane now are students who choose to be there.

Blakeley cites that over 50% of the graduates in Spokane remain in Eastern Washington to practice. Establishing more opportunities for residency in non-urban areas is the challenge of retaining physicians, since the location of residency is a major predictor of where someone will practice.

In rural areas, the physician work force is not adequate, Blakeley said. Thats the reason WWAMI was started in the first place: to train a physician workforce for the five-state region that struggles to get physicians to work in these small towns.

UW-Gonzaga hopes the new building set to open in August 2022 will expand the medical program from its current capacity of 60 per cohort to 80.

Reach reporter Theresa Li at news@dailyuw.comTwitter: @lithere_sa

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Construction begins on new UW Medicine teaching facility in Spokane - Dailyuw

Caladrius Biosciences to Present at the Alliance for Regenerative Medicine’s Virtual Cell and Gene Meeting on the Mesa – GlobeNewswire

BASKING RIDGE, N.J., Oct. 07, 2020 (GLOBE NEWSWIRE) -- Caladrius Biosciences, Inc. (Nasdaq: CLBS) (Caladrius or the Company), a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse, not manage, disease, announced today that its Chief Medical Officer, Douglas W. Losordo, M.D., FACC, FAHA, will present at the Alliance for Regenerative Medicines (ARM) Cell and Gene Meeting on the Mesa, being held virtually on October 12-16, 2020.

The 2020 Cell and Gene Meeting on the Mesa will be delivered in a virtual format over the course of five days where attendees will be able to watch company presentations on-demand, in addition to two live-streaming panels each day. The Cell and Gene Meeting on the Mesa is the sectors foremost annual conference, bringing together senior executives and top decision-makers in the industry to advance cutting-edge research into cures. Tackling the commercialization hurdles facing the cell and gene therapy sector today, this meeting covers a wide range of topics from clinical trial design to alternative payment models to scale-up and supply chain platforms for advanced therapies.

For more information on the conference, or to register, please visithttps://www.meetingonthemesa.com.

About Caladrius Biosciences

Caladrius Biosciences, Inc. is a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse, not manage, disease. We are developing first-in-class cell therapy products based on the notion that our body contains finely tuned mechanisms for self-repair. Our technology leverages and enables these mechanisms in the form of specific cells, using formulations and modes of delivery unique to each medical indication.

The Companys current product candidates include CLBS119, a CD34+ cell therapy product candidate for the repair of lung damage found in patients with severe COVID-19 infection who have experienced respiratory failure, for which the Company plans to initiate a clinical trial in the coming weeks as well as three developmental treatments for ischemic diseases based on its CD34+ cell therapy platform: HONEDRA (formerly CLBS12), recipient of SAKIGAKE designation and eligible for early conditional approval in Japan for the treatment of critical limb ischemia (CLI) based on the results of an ongoing clinical trial; CLBS16, the subject of a recently completed positive Phase 2 clinical trial in the U.S. for the treatment of coronary microvascular dysfunction (CMD); and CLBS14, a Regenerative Medicine Advanced Therapy (RMAT) designated therapy for which the Company has finalized with the U.S. Food and Drug Administration (the FDA) a protocol for a Phase 3 confirmatory trial in subjects with no-option refractory disabling angina (NORDA). For more information on the company, please visit http://www.caladrius.com.

Contact:

Investors:Caladrius Biosciences, Inc.John MendittoVice President, Investor Relations and Corporate CommunicationsPhone:+1-908-842-0084Email:jmenditto@caladrius.com

Media:W2O GroupChristiana PascalePhone: +1-212-257-6722Email:cpascale@w2ogroup.com

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Caladrius Biosciences to Present at the Alliance for Regenerative Medicine's Virtual Cell and Gene Meeting on the Mesa - GlobeNewswire

CLINE FAMILY MEDICINE PRESENTS 13TH ANNUAL HEALTH AND FITNESS FAIR: Friday, October 16 – The Light and Champion

CLINE FAMILY MEDICINE PRESENTS13 TH ANNUAL HEALTH AND FITNESS FAIR

The 13 th Annual Health and Fitness Fair, Presented by Cline Family Medicine will be held nextweek on Friday, October 16th at the Windham Civic Center from 9:00 a.m. until 12 noon. GoldSponsors Focused Care of Center, Hope Community Medicine and Nacogdoches MedicalCenter also helped in making the event a success.

This years theme is Healthy Living. Healthy Living is when our physical and mental health arein balance and functioning well. Healthy Living is a lifestyle choice which includes healthyeating, regular exercise and good sleep habits. Experts will be available at the Fair withinformation to help you achieve your Healthy Living goals.

Clines Family Medicine will be offering Flu Shots. There will be new vendors and newinformation.

A Scavenger Hunt will be held again with three drawings at the end of the Health Fair. Prizesinclude ear buds, a healthy gift basket and a 32-Inch Flat Screen TV. Attendees and vendorsare invited to participate in finding items throughout the fair.

The fair is free to the public featuring over 30 vendors with give aways and door prizes. Maskswill be required and available.

The purpose and goal of the Shelby County Chamber of Commerce Healthcare Committee andthe Health and Fitness Fair is to educate Shelby County and the surrounding areas about healthcare resources available in the area and about their personal health. There will be a variety ofhealth screenings available including glucose, cholesterol, bone density, spinal screenings,heart awareness, diabetes information, allergy testing information and vision.

For more information please contact the Shelby County Chamber of Commerce at(936) 598-3682, email info@shelbycountychamber.com or visit http://www.shelbycountychamber.com.

Here is some more info - Cline's Flu Shots for $25.00 or insurance card and info on the new Body Lab. Hope Community Medicine - Mental Health and Breast Cancer Awareness info. CHI St. Lukes - Diabetes Information. Cornerstone Physical Therapy and Balance Center - Balance Testing. Stanley Center for Speech and Language Disorders (SFA) - Hearing Screenings.

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CLINE FAMILY MEDICINE PRESENTS 13TH ANNUAL HEALTH AND FITNESS FAIR: Friday, October 16 - The Light and Champion

Global Precision Medicine Market 2020-2030: Market to Reach $278.61 Billion by 2030 – A Frontier in the Genesis of Patient-centric Medicine – WFMZ…

DUBLIN, Oct. 7, 2020 /PRNewswire/ -- The "Global Precision Medicine Market: Focus on Ecosystem, Technology, Application, Country Data (21 Countries), and Competitive Landscape - Analysis and Forecast, 2020-2030" report has been added to ResearchAndMarkets.com's offering.

Global Precision Medicine Market to Reach $278.61 Billion by 2030

Precision medicine refers to the medicine developed as per an individual's genetic profile. It provides guidance regarding the prevention, diagnosis, and treatment of diseases. The segmentation of the population is done depending on the genome structure of the individuals and their compatibility with a specific drug molecule.

In the precision medicine market, the application of molecular biology is to study the cause of a patient's disease at the molecular level, so that target-based therapies or individualized therapies can be applied to cure the patient's health-related problems.

This industry is gaining traction due to the increasing awareness about healthcare among individuals, integration of smart devices such as smartphones and tablets into healthcare, and increasing collaborations and agreements of IT firms with the diagnostics and biopharmaceutical companies for the development of precision diagnostic tools.

Within the research report, the market is segmented on the basis of product type, ecosystem application, and region, which highlight value propositions and business models useful for industry leaders and stakeholders. The research also comprises country-level analysis, go-to-market strategies of leading players, future opportunities, among others, to detail the scope and provide 360-degree coverage of the domain.

Key Topics Covered:

1 Product Definition

2 Research Scope

3 Research Methodology

4 Global Precision Medicine Market Overview4.1 Market Definition4.2 Precision Medicine: A Frontier in the Genesis of Patient-centric Medicine4.3 Precision Medicine: Remodeling the One-Size-Fits-All Theory to Individually Tailored Therapy4.4 Initiatives and Programs4.5 Precision Medicine: Enabling Technologies and Applications4.5.1 Innovators4.5.1.1 3D DNA Printing4.5.1.1.1 Introduction4.5.1.1.2 Role of 3D DNA Printing4.5.1.2 RNA-Seq4.5.1.2.1 Introduction4.5.1.2.2 Role of RNA-Seq in Precision Medicine4.5.1.2.3 Key Players4.5.1.3 4D Molecular Imaging4.5.1.3.1 Introduction4.5.1.3.2 Role of 4D Molecular Imaging in Precision Medicine4.5.1.3.3 Key Players4.5.2 Early Adopters4.5.2.1 CRISPR4.5.2.1.1 Introduction4.5.2.1.2 Role of CRISPR in Precision Medicine4.5.2.1.3 Key Players4.5.2.2 Blockchain4.5.2.3 Imaging Informatics4.5.3 Early Majority4.5.3.1 Artificial Intelligence (AI)4.5.3.2 Circulating Free DNA (cfDNA)4.5.3.3 Big Data4.5.3.4 Next-Generation Sequencing (NGS)4.5.3.5 Health Informatics4.5.3.6 Bioinformatics4.5.4 Late Majority4.5.4.1 Polymerase Chain Reactions (PCR)4.5.4.2 Microarray4.6 COVID-19 Impact on the Global Precision Medicine Market

5 Market Dynamics5.1 Overview5.2 Market Drivers5.2.1 Advancement of Sequencing Technologies5.2.2 Rising Prevalence of Chronic Diseases5.2.3 Growing Demand for Preventive Care5.2.4 Shifting the Significance in Medicine, from Reaction to Prevention5.2.5 Reducing Adverse Drug Reactions Through Pharmacogenomics Test5.2.6 Potential to Reduce the Overall Healthcare Cost Across the Globe5.3 Market Restraints5.3.1 Unified Framework for Data Integration5.3.2 Limited Knowledge about Molecular Mechanism/ Interaction5.3.3 Lack of Robust Reimbursement Landscape5.3.4 Regulatory Hurdles5.4 Market Opportunities5.4.1 Targeted Gene Therapy5.4.2 Expansion into the Emerging Markets5.4.3 Collaboration and Partnerships Across Value Chain to Accelerate the Market Entry

6 Industry Insights6.1 Patent Analysis6.2 Legal Requirements and Regulations6.3 Pipeline Analysis6.4 Legal Requirements and Framework by the FDA6.5 Legal Requirements and Framework by the EMA6.6 Legal Requirements and Framework by the MHLW

7 Competitive Landscape7.1 Synergistic Activities7.1.1 Product launches, Enhancements, and Upgradation7.1.2 Product Approvals7.1.3 Mergers and Acquisitions7.1.4 Business Expansion7.2 Market Share Analysis7.2.1 Market Share Analysis by Applied Sciences, 20197.2.2 Market Share Analysis by Precision Diagnostics, 20197.2.3 Market Share Analysis by Precision Therapeutics, 20197.2.4 Market Share Analysis by Digital Health and IT, 2019

8 Global Precision Medicine Market (by Ecosystem)8.1 Overview8.2 Applied Sciences8.2.1 Genomics8.2.2 Global Precision Medicine Genomics Market (by Technology)8.2.2.1 Polymerase Chain Reaction (PCR)8.2.2.2 Next-Generation Sequencing (NGS)8.2.2.3 Genome Editing8.2.2.4 Other Technologies8.2.3 Pharmacogenomics8.2.4 Other Applied Sciences8.3 Precision Diagnostics8.3.1 Molecular Diagnostics (MDx)8.3.2 Global Precision Medicine Molecular Diagnostics Market (by Type)8.3.2.1 Non-Invasive Prenatal Testing (NIPT)8.3.2.2 Companion Diagnostics8.3.2.3 Liquid Biopsy8.3.2.4 Other Molecular Diagnostics8.3.3 Medical Imaging8.3.3.1 Global Precision Medicine Medical Imaging Market (by Type)8.3.3.1.1 Imaging Analytics8.3.3.1.2 Imaging Computer-Aided Detection (CADx)8.3.3.2 Global Precision Medicine Medical Imaging Market (by Region)8.4 Digital Health and Information Technology8.4.1 Global Precision Medicine Digital Health and Information Technology Market (by Type)8.4.1.1 Clinical Decision Support Systems (CDSS)8.4.1.2 Big Data Analytics8.4.1.3 IT Infrastructure8.4.1.4 Genomics Informatics8.4.1.5 In-Silico Informatics8.4.1.6 Mobile Health8.5 Precision Therapeutics8.5.1 Global Precision Medicine Therapeutics Market (by Type)8.5.1.1 Clinical Trials8.5.1.2 Cell Therapy8.5.1.3 Drug Discovery and Research8.5.1.4 Gene Therapy

9 Global Precision Medicine Market (by Application)9.1 Overview9.2 Oncology9.2.1 Cancer Precision Medicine Drugs and Indications9.3 Infectious Diseases9.3.1 Infectious Diseases Precision Medicine Drugs and Indications9.4 Neurology9.4.1 Neurology Precision Medicine Drugs and Indications9.5 Cardiovascular9.5.1 Cardiovascular Precision Medicine Drugs/Tests/ and Indications9.6 Lifestyle and Endocrinology9.6.1 Endocrinology Precision Medicine Drugs and Indications9.7 Gastroenterology9.7.1 Gastroenterology Precision Medicine Drugs and Indications9.8 Other Applications9.8.1 Precision Drugs for Other Applications

10 Global Precision Medicine Market, (by Region)

11 Company Profiles11.1 Company Overview11.2 Role of Abbott Laboratories in Global Precision Medicine Market11.3 Financials11.4 Key Insights About Financial Health of the Company

For more information about this report visit https://www.researchandmarkets.com/r/45j44d

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Global Precision Medicine Market 2020-2030: Market to Reach $278.61 Billion by 2030 - A Frontier in the Genesis of Patient-centric Medicine - WFMZ...

Lesson of the Day: Laughter May Be Effective Medicine for These Trying Times – The New York Times

Option 1: Create a Laughter First-Aid Box.

In the article, Mary Laskin, a nurse case manager, said she recommended laughter first-aid boxes for her patients, where they can stash joke books, funny toys and other props for this purpose.

Assemble your own laughter first-aid box. It can be a physical kit like the one pictured above, or a collection of digital artifacts, such as funny video and movie recommendations, entertaining social media accounts to follow, a playlist of songs that make you chuckle, or anything else.

Make a list of all the things you would include in your box. Then, if you have time, put it together and send it to someone you care about or squirrel it away for yourself when youre in need of cheering up.

Option 2: Play With Your Pain.

Try this exercise suggested in the article:

Charlie Chaplin once said, In order to truly laugh you need to be able to take your pain and play with it, said Paul Osincup, the president of the Association for Applied and Therapeutic Humor. Write down all of the most difficult and annoying things about quarantine, Mr. Osincup recommends. Play with those. See if you can find any humor in your situation.

Once youve created your list, see if you can find something to laugh about in any of the things you wrote down. Then choose one of those experiences and make something funny from it. You might write a joke or a tweet, perform a comedy sketch or a stand-up bit, create a meme or a TikTok video. Whatever you make, share it with someone to make them laugh.

Then, reflect: What was it like to take your pain and play with it? What was the response when you shared your joke with others? How did that feel?

Option 3: Weigh In on Our Related Student Opinion Question.

In the early days of the coronavirus pandemic, we asked students, Is It OK to Laugh During Dark Times?

Many students said yes. Julia Grandpre from Sarasota, Fla., wrote:

It is very important that we continue to laugh during these times. As a person who tends to dwell in negative thoughts, I believe that laughter is the best medicine right now. To find the fun in this situation, is not to take away from its severity, its just a coping mechanism As people we need a bright side to look for, and since we are quarantined, laughter and the sharing of creativity is the best way to bring us together.

But a few, like Lauren Ackermann from Glenbard West High School in Glen Ellyn, Ill., warned:

Honestly, I see our generation as one where it has become easier than ever to make what some would call insensitive jokes about pretty much anything because its easier to laugh at a dark joke on a screen just like its easier to cyber bully someone through a screen. In both cases, you dont directly see who you would impact by making a comment so you become disconnected from possible consequences. It might make you feel better to post that witty comment about people dying from coronavirus, but we all need to be mindful about how that comment would be perceived by people whose lives have been torn apart by the event you just laughed at.

What do you think? Read what else teenagers had to say, then add your voice to the conversation.

About Lesson of the Day

Find all our Lessons of the Day in this column. Teachers, watch our on-demand webinar to learn how to use this feature in your classroom.

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Lesson of the Day: Laughter May Be Effective Medicine for These Trying Times - The New York Times

Penn Medicine finds hydroxychloroquine ineffective in preventing COVID-19 – The Daily Pennsylvanian

Researchers did not see an effect associated with hydroxychloroquine among the study participants. (Photo by Ajale on Pixabay)

Hydroxychloroquine is no more effective than a placebo in preventing COVID-19, researchers at the Perelman School of Medicine found.

There was no difference in infection rates among health care workers who took the drug daily and those who took a placebo, according to Penn Medicine News. The study was published on Sept. 30 in the Journal of the American Medical Association: Internal Medicine.

A placebo is a medical treatment designed to deceive a participant in a clinical experiment because it does not contain any active ingredients.

While the researchers did not see an effect associated with HCQ, overall infection rates remained low among participants, Penn Medicine News reported. The researchers believe this is the result of the effectiveness of other prevention methods, such as social distancing, use of personal protective equipment, and proper hand hygiene.

The study included 125 health care workers from the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center, including the emergency departments and COVID-19 units.

Associate professor of medicine Ravi Amaravadi and professor of emergency medicine Benjamin Abella led the clinical trials. Between April 9 and July 14, roughly half of the participants received HCQ and roughly half received a matching placebo.

At the end of the study, 6.3% of those who took HCQ tested positive and 6.6% of those who took the placebo tested positive. There was also no difference detected in the heart rhythms of either group, which showed that while the drug did not prevent against COVID-19, it was not detrimental aside from temporary side effects, Penn Medicine News reported.

To really test the potential of HCQ as a prevention drug, we felt it was key to recruit health care workers with many hours of direct physical exposure to COVID-19 patients, then randomize them in a double-blind manner between hydroxychloroquine or a matching placebo, and treat them for a long period of time, Amaravadi told Penn Medicine News.

At the start of the pandemic, studies suggested HCQ which is used to treat arthritis and malaria could be an effective treatment for COVID-19, but follow-up studies have found less promising results, The New York Times reported.

The drug gained national prominence in March when President and 1968 Wharton graduate Donald Trump tweeted about it as a potential COVID-19 treatment. Trump, who announced he tested positive for the virus on Friday, announced in May that he was taking the drug.

A lot of good things have come out. Youd be surprised at how many people are taking it, especially the front line workers, Trump said at the White House. "I happen to be taking it."

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Penn Medicine finds hydroxychloroquine ineffective in preventing COVID-19 - The Daily Pennsylvanian

Penn Medicine Researchers Receive Prestigious National Institutes of Health Directors Awards – Newswise

Newswise PHILADELPHIA Picture a future where embedded medical devices not only treat and teach patients, but learn from them. Imagine chronic pain being managed without the negative side effects of opioids. Penn Medicine researchers are working to make those scenarios a reality. These initiatives are among innovative new National Institutes of Health (NIH) funded efforts that are mapping the future of medicine.

The NIH has selected two researchers from the Perelman School of Medicine at the University of Pennsylvania to receive its prestigious Directors Awards, part of the NIH Common Funds High-Risk, High-Reward Research Program honoring exceptionally creative scientists. Brian Litt, MD, a professor of Neurology, Neurosurgery, and Bioengineering, was honored with a Pioneer Award for $5.6 million, supporting novel neurodevice research. Gregory Corder, PhD, an assistant professor of Psychiatry and Neuroscience, was selected as a New Innovator Award winner, receiving $2.4 million for research investigating the mechanisms of chronic pain.

This NIH initiative, designed to fuel research endeavors that are more opened-ended and have a potentially broader effect on scientific understanding compared to more traditional research, awards these to scientists to support research over a five-year period. The 2020 Penn recipients are among 85 awardees nationally:

Pioneer Award Ghost in the Machine: Melding Brain, Computer and Behavior

The Pioneer Award challenges investigators to pursue new research directions and develop groundbreaking, high-impact approaches to a broad area of biomedical or behavioral science. This award supports Litts work to develop a new generation of autonomous neurodevicesimplanted machines that can question, record, and combine learning algorithms based on neurological signals and feedback to act and alter human behavior on the fly.

In epilepsy, for example, these devices would predict and prevent seizures; in Parkinsons patients, implants will measure and communicate with patients to improve mobility, reduce tremor and enhance responsiveness. Other implants might improve hearing or psychiatric symptoms by querying patient perceptions, feelings, and altering stimulation patterns algorithmically to improve them. The loop is closed in real time, so the host can change their behavior based upon device feedback to improve their health.

Imagine this: A 30 year-old veteran walks into a bar. None of the patrons are aware of the anti-seizure device in his brain, or the traumatic brain injury that requires it. After he drinks a beer, his phone vibrates with a text from the implantable device asking what hes doing and sharing his probability of a seizure has increased. And with a quick explanation from the veteran, the device stimulates and suggests avoiding a second beverage, Litt explains. Were working towards this future, with the help of the Pioneer Award.

This is a paradigm shift from todays simple devices, which rely on physicians to give device feedback to patients and change simple parameters by hand during occasional office visits. Litts goal is to build a foundation for responsive implants that can collaborate with hosts, linking human experience and perception to machine algorithms, actions, and therapy, predicting and preventing events before they start. Not only will the patient teach the device, but the device will teach the patient.

Grant ID: DP1 NS122038-01.

New Innovator Award Harnessing Cortical Neuromodulation to Disrupt Pain Perception

The New Innovator Award supports unusually innovative research from early career investigators who have not yet received a research project grant or equivalent NIH grant. The award will support Corders efforts to research the mechanisms of chronic paina major health crisis in the United States, affecting millions, and a driver of the opioid epidemic.

Corders goal is to identify which parts of the brain are important for pain perception and which circuits impact pain relief from opioids. He hopes to decode how this neural activity evolves during chronic pain. Once the brain circuits and pathways that contribute to the suffering and perception of pain are identified, they can be targeted for potential therapeutics which could be more effective at reducing pain and without the addictive elements of prescription opioids.

Corder envisions these next generation pain therapeutics leveraging viral-delivered cell-specific gene therapies to disrupt the pain-processing circuits in the cortex. This would will allow patients to sense pain but without the unpleasant aversion.

We currently have a limited understanding of the neural pathways in the brain that contribute to pain, which has been a significant barrier for treating pain efficiently, without negative side effects. But, if we can identify and understand these circuits, we can then try to rewrite the neural code of pain, Corder said. Picture being able to specifically target the one desired brain region or circuit that processes pain in order to provide pain relief. This research will help us lay the groundwork for new classes of therapeutics, which could have a profound and broad impact for treating patients with chronic pain, while reducing the burden of the national opioid crisis.

Grant ID: DP2 GM140923-01.

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Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $8.6 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $494 million awarded in the 2019 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 43,900 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2019, Penn Medicine provided more than $583 million to benefit our community.

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Penn Medicine Researchers Receive Prestigious National Institutes of Health Directors Awards - Newswise

Medicine Nobelist wants science awards to be ‘more inclusive’ – Times Higher Education (THE)

The British-born virologist who shared this years Nobel prize for medicine has called on award committees to be more inclusive and expansive when recognising scientific achievements but has dismissed speculation that he might have turned down sciences top award because his collaborators had not been recognised.

When Michael Houghton was named one of three winners of the Nobel Prize in Physiology or Medicine for his work on the hepatitisC virus on 5October, some pundits flagged the London-born scientists previous criticism of other academic awards that, like the Nobels, have chosen to honour only a select group of individuals linked to a scientific discovery.

In 2013, Professor Houghton, who is the Canada Excellence research chair in virology and LiKaShing professor of virology at the University of Alberta, turned down the C$100,000 (58,000) Canada Gairdner International Award because his colleagues Qui-Lim Choo and George Kuo, with whom he worked for seven years at the California-based biotech firm Chiron, were not recognised.

However, at a press conference this week, Professor Houghton said in response to a question from Times Higher Education that it would be too presumptuous of me to turn down aNobel.

The Nobel is the longest traditional prize in all fields, not just biomedicine and their regulations and processes are based on Alfred Nobels will, said Professor Houghton.

His decision to reject the Gairdner Prize was an entirely different situation, he explained. That prize, first awarded in 1958, was not as long-standing as the Nobel, and other newer scientific prizes had been more flexible with their rules, Professor Houghton said.

In his case, he had engaged in a discussion with the prizes committee in the hope that it could break a few rules, he explained.

However, discussions had become alittle heated and he felt unable to accept the prize, despite regretting the embarrassment that he, avisitor, had caused by snubbing one of Canadas top biomedicine prizes, he said.

I was trying to influence how awards are given, explained Professor Houghton, who said he believed that newer prizes that modelled themselves on the Nobel with itsmaximum of three winners per prize could instead be more inclusive and expansive.

Major breakthroughs in modern science were notachieved by just three people but probably six or seven, he said, adding that, in future, anumber of committees that are not steeped in the tradition [that] the Nobel [committeeis] could be more inclusive and expansive in recognising these broader scientific teams.

Great science comes from groups of people, and somehow we need to include that into [award] policies, Professor Houghton said of future prize-giving.

In the case of the Nobel committee, it was not feasible to discuss these things with them, he said, referring to its long-standing three-person maximum and the fact that it notifies winners only minutes before announcing their honour.

Professor Houghton, who shared this years medicine prize with the US scientists Harvey Alter and Charles Rice, is only the second Canada-based scientist to claim a medicine Nobel, almost a century after its first winner, insulin co-discoverer Frederick Banting, was honoured in 1923. Professor Houghton took a PhD in biochemistry at Kings College London after undergraduate study at the University of East Anglia. He later moved to Alberta and now splits his time between Canada and California, where his family is based.

David Pendlebury, a senior researcher at Clarivate Analytics, commented that Professor Houghton was a worthy recipient of the Nobel given the public health dimensions of hepatitisC and the importance of this discovery, but his stance on awards had jeopardised not just his inclusion on the award, but recognition of the achievement altogether.

History tells us that the Nobel committee has to make hard choices among possible and competing honorees in order to stay within the Nobel prize rule of three limit, said Dr Pendlebury. With so many worthy discoveries and discoverers waiting, it is always a safer option to choose an award that does not have a priority or credit controversy builtin, he said.

The surprise was the decision to award [the Nobel to hepatitisC researchers] based on the fact that more than three researchers were instrumental in this discovery, demonstrating how much more global and collaborative the research ecosystem is today than in Nobels day.

jack.grove@timeshighereducation.com

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Medicine Nobelist wants science awards to be 'more inclusive' - Times Higher Education (THE)