How disassociation occurs in the brain – Medical News Today

Researchers may now have gained a better understanding of how the brain causes the disorienting, disruptive sensation of being outside of ones body.

Most of the time, the mind and body operate seamlessly as a single entity. At times, however, a person may experience a disconcerting sense of disassociation, during which they feel as if they are somewhere outside of their body looking in.

According to Dr. Karl Deisseroth who is a professor of bioengineering, psychiatry, and behavioral sciences at Stanford University in California almost 3 out of 4 people who experience trauma report this phenomenon occurring either during or some time afterward.

Also, around 210% of the general population experience it at some point in their lives, he adds.

Recently, Dr. Deisseroth and colleagues conducted a study that allowed them to identify, for the first time, the brain mechanism that initiates disassociation.

They have now reported their findings in the journal Nature.

The feeling of disassociation begins with nerve cells in the brains posteromedial cortex firing synchronously at a specific rate.

Disassociation can be both troubling and disruptive, and it may become chronic. In order to develop treatments, and to understand the biology, we needed to know more, says Dr. Deisseroth.

Now, he adds, This study has identified brain circuitry that plays a role in a well-defined subjective experience.

Beyond its potential medical implications, it gets at the question, What is the self? Thats a big one in law and literature, and important even for our own introspections.

The study also describes the molecular foundation underlying the mechanism that causes disassociation.

Dr. Deisseroth describes disassociation metaphorically as the perception of being on the outside looking in at the cockpit of the plane thats your body or mind and what youre seeing you just dont consider to be yourself.

Indeed, the study is, in part, based on observations of a person who described the experience as being outside the pilots chair, looking at, but not controlling, the gauges.

The study authors were working with this individual as part of the Stanford Comprehensive Epilepsy Program. He experienced disassociation during preseizure auras, which refers to the time period directly preceding seizures.

The researchers recorded electrical signals from the individuals cerebral cortex in an attempt to identify the brain activity causing his seizures. They noticed a particular pattern of electrical activity that coincided with the aura. It was occurring in the posteromedial cortex.

The researchers observed a particular rhythm being generated by nerve signals firing synchronously. The signal pulsed at 3 Hertz (Hz), or three times per second.

They subsequently found that if they deliberately stimulated this area of the brain electrically, the individual experienced a disassociation aura but no subsequent seizure.

Previous research has suggested that mice experience disassociation as indicated by changes in their behavior.

For example, if a mouse located on an uncomfortably warm surface simply lifts its foot without licking it to soothe it as would be expected it is likely experiencing disassociation. Scientists can induce this state using the drug ketamine.

In the recent study, the researchers attempted to cause disassociation in mice by using light to optogenetically stimulate neurons in the rodent equivalent of the human posteromedial cortex.

When they applied stimulation at the same 3-Hz rate they saw in the human brain, they saw disassociative behavior without the presence of ketamine.

Additional research led to the discovery that a specific protein type called an ion channel is necessary for the generation of the 3-Hz pulse.

Recognizing the role of these proteins could lead to the development of new therapies that more effectively address disassociation and the conditions with which it is often associated, such as epilepsy, borderline personality disorder, and PTSD.

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How disassociation occurs in the brain - Medical News Today

The Horror of Medical School Captured on Film – Medscape

This Q&A has been edited for clarity.

What if the figurative terror faced by medical students was turned into literal, tangible horror?

Phillip Anjum, a third-year medical student at The Ohio State University College of Medicine in Columbus, Ohio, wanted to find a new way to demonstrate the stress, anxiety, and isolation experienced by medical trainees. Drawing upon his background in film, he made History of Present Illness, a horror short that tackles med student burnout in a more visceral way.

We spoke with Anjum about what he hopes school administrators and others in medicine take from his project, as well as his experience of balancing filmmaking with becoming a doctor.

The first 2 years of medical school are rough. I don't think anyone has a smooth ride. I wanted to represent that in a way that was unique and also not in a way that is constantly sugarcoated by medical schools. I think all medical schools suggest that, when you come there, you are taken care of. You have your classmates and your advisors, and everyone is supporting you and you get through it. But when you actually get there, you realize that medical training in general is a very isolating experience.

I think there's no way that you can get around that, and I think the sooner that you realize that and develop ways to deal with the stress and anxiety, the sooner you can be successful in your training.

We all feel lonely. I think there's a lot of fear of physicians expressing their insecurities, expressing their shortcomings and saying, "I'm stressed. I'm depressed." I think I just wanted to get that out there through the film and say that everyone is struggling in some aspect. That's the biggest thing I wanted to capture.

Writer/director Phillip Anjum and actress Caitlin Wilson discuss a scene from the film.

Yes, that part always made me nervous! I think it's important to be critical of the administration, of your teachers, at times. I have had advisors who I love, people that I can talk to. That's not the point. The point is that especially with the COVID pandemic and with the ongoing protests there is definitely a feeling that support from the administration is lacking at certain times when we need it the most.

I wanted to make something that was critical and more than just saying something in an email. I think emails and words get brushed aside a lot more easily than a video piece that's speaking to someone emotionally. I wanted to say, "This is what it feels like. This is what it looks like when you're not there for a medical student."

I think, from the students, it's gotten pretty universal praise. Every single medical student or resident who has watched it has said that they have felt pretty similar at times. I've also gotten a lot of comments that every medical school seems to have a scary basement, which is a little bit unnerving...

In terms of the administration, I've kind of avoided spreading it too far, just because of the fear that it is critical. I've gotten a bit more measured responses from administration. I think there's a hesitancy from students to produce anything that's critical.

Medical schools could do a much better job of simply taking what the students say and then implementing that. I think a lot of our classmates feel that administration just doesn't listen. They say that they'll do something but then they don't actually do it. I would say more follow-through.

Actors Stephen Manos and Caitlin Wilson in a scene from History of Present Illness.

I do have a bigger project on the way. It's about the fourth year of medical school. It's almost the exact opposite of this short. History of Present Illness is a horror film. It's about feeling isolated. It's about feeling like you are on your own.

This other film, tentatively called A Place For Us, is about two medical students who are about to graduate. They're looking back on the people and the doctors that they have become. That one is more of a drama. It comes from a place of strength. It's meant to be a foil to History of Present Illness.

I think, for all doctors and providers, it's so much more important nowadays to have an awareness of your media presence. People need to be aware of how you can use a photo on Instagram or a TikTok video to your advantage in terms of providing clinical care, clinical information, and also just good PR. I mean, we've seen throughout this pandemic I won't go into specifics about anything political but there's definitely been a lot of back-and-forth from providers and non-providers in terms of advice about the coronavirus. I think that with better PR and better communication, you can swing what people listen to.

I feel like I'm urged to choose something medical, but... I'd recommend two films that really influenced me. One is Moonlight, which I really just love. In general, whether you're a provider or just whoever you are, I recommend that movie. It covers a lot of topics, like racial disparities, disadvantaged populations, healthcare insecurity, drugs, and just everything. It's a beautiful film.

Speaking of beautiful, the other one that I really love is the movie Biutiful. Both of those films are about men who struggle with who they are and what they want to do with their lives. I think that's something that speaks to me.

Editor's note: History of Present Illness was first published on in-Training.

Ryan Syrek, MA, is the section editor for medical student and resident content at Medscape.

Phillip Anjum is a third-year medical student at The Ohio State University College of Medicine in Columbus, Ohio. He enjoys making films and spending time with his wife.

For more news follow Medscape on Facebook, Twitter, Instagram, and YouTube

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What Are Your Chances of Getting Into Medical School? – Yahoo News

Only about 41% of applicants to U.S. medical schools who sought admission for the 2019-2020 school year matriculated, according to official statistics released by the Association of American Medical Colleges.

That's one reason why medical school admissions experts advise applicants to get a realistic perspective of their credentials before deciding when and where to apply.

Glen Fogerty, an associate dean of admissions and recruitment at the University of Arizona College of Medicine--Phoenix, encourages med school hopefuls to look up statistics on the MCAT scores and GPAs of admitted students at their target schools.

"Past that, they could also review previous class profiles and see if these medical schools provide any type of overview of clinical or research experience or the type of extracurricular activities their students participated in," he wrote in an email. "Now, with this said, I would recommend that applicants gain the clinical, research and extracurricular activities that are meaningful to them and not try to fit into any medical school profile. Following their own path will serve the applicant best as the person will then find the medical school that is the best match for them as well."

[Read: Why It's Hard to Get Into Medical School Despite Doctor Shortages.]

One resource experts recommend applicants use to estimate their chances of getting into medical school is an MCAT-GPA grid published by the AAMC. The grid notes the acceptance rates among premeds with various combinations of GPAs and Medical College Admission Test scores using aggregated data from the 2017-2018 through the 2019-2020 admissions cycles.

For instance, the grid shows that 87.8% of applicants to U.S. med schools who had both an MCAT score that exceeded 517 and a GPA that surpassed 3.79 were accepted.

"Metrics like GPA and MCAT scores are often where students start to assess their competitiveness for medical school, but there's more to it than just metrics," wrote Dr. Renee Volny Darko, founder and CEO of admissions consulting firm Pre-med Strategies Inc., in an email. "Life experiences play an important role in establishing a student's ability to compete. Extracurricular activities such as employment, volunteering, clinical experience, research, and shadowing doctors are where students can not only showcase themselves to admissions committees, but also solidify for themselves that medicine is worth pursuing."

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Darko says there are situations when it makes sense for a prospective student to wait a year to apply to medical school to allow time to improve his or her candidacy. "Sometimes being patient and deferring the application is the best strategy," she says. "It gives time to become more competitive and the applicant doesn't have to explain previous rejection from medical school."

Medical school admissions officers urge premeds to remember that numbers are not the only component of their application that matters.

"Most medical schools these days use what we call holistic review, which means that they put an equal emphasis on the academic record and the experiences that the candidate has had and, finally, the personal attributes of the candidate," says Dr. Quinn Capers IV, vice dean of faculty affairs and professor of cardiovascular medicine at the Ohio State University College of Medicine.

He says med schools care about candidates' communication skills, collegiality, teamwork abilities and how well they take feedback. Capers recommends that med school hopefuls apply to no fewer than 16 schools to maximize their admissions chances.

Capers says that, in past eras, medical schools focused primarily on academic factors, such as GPAs and MCAT scores, but now these schools have expanded the number of factors they consider when making admissions decisions.

"You have to have a strong academic record, but in addition, you also have to have a strong record of experiences that show you want to help your fellow man, and you have to be able to prove that you have the attributes that we want to see in medicine," he says.

Capers adds that his school evaluates the quality of prospective students' extracurricular activities, including leadership experiences, health-related activities, research and community service. A lack of community service experience can be a deal breaker in the admissions process, he says, since that type of experience is something that medical schools specifically look for.

[Read: 4 Activities That Make Strong Medical School Candidates.]

David Lenihan, president of Ponce Health Sciences University in Puerto Rico, says he looks for well-rounded individuals who have done something interesting in college beyond studying hard and doing well in courses. Lenihan, who has a Ph.D. in neurosurgery and electrophysiology, says he appreciates when premeds have participated in extracurricular activities such as sports, band or drama.

"A well-rounded student makes a much better doctor in the long run, and I believe that it's that well-rounded student that's more likely to go into areas of need and practice," he says. For example, Lenihan says he was intrigued by a candidate who was a concert violinist, because the activity was memorable, distinctive and required commitment.

He suggests that students with passions outside of their schoolwork can bring those up during their medical school interviews in order to distinguish themselves. Candidates who pursued a nonacademic project while preparing for the MCAT could discuss how they maintained a balance and juggled those two commitments, he says.

Lenihan also notes that students should look for schools that have a strong academic program in whatever medical specialty they are most fascinated by, whether it is rural medicine or psychiatry, for example. He also advises that students should look for med schools with mission or vision statements that align with their personal goals. "They'll pick up on that, and that will help improve your odds," he says.

Highly ranked research-focused medical schools tend to seek students with sterling academic statistics and scholarly achievements, Lenihan says, since a core component of those schools' missions is to train leaders in the academic sphere of medicine, such as medical school professors and physician scientists.

In contrast, Lenihan says his primary objective is to recruit med students who have the potential to become great clinicians, and he argues that premeds with 4.0 undergraduate GPAs aren't necessarily the ones who will be most effective at treating patients.

Dr. G. Richard Olds, president of St. George's University, an international academic institution with a campus in the Caribbean, says the most common mistakes in the med school admissions process are either not applying to a sufficient number of schools or not applying to the most appropriate types of schools. Olds says it's crucial to apply to a wide range, including reach, match and safety schools.

Residency and citizenship status are also an important factor in the medical school admissions process, particularly at state schools that have a strong preference for admitting in-state students, says Dr. McGreggor Crowley, a medical school admissions counselor with the admissions consulting firm IvyWise.

"Some states are uber-competitive, like California and Massachusetts, where the large populace of state citizens makes admission to their medical schools quite challenging ... In states where the population is smaller, and the pool of qualified applicants is proportionally smaller, competition can be a bit less severe, and out-of-state residents may have better chances," Crowley wrote in an email. "National citizenship status is also important, and international citizens, even if they matriculate in American colleges and universities for their undergraduate degrees, are still at a disadvantage in the selection process."

[Read: How to Find U.S. Medical Schools That Accept International Students.]

Crowley says prospective students need to do an honest self-assessment to figure out whether they are competitive for medical school and whether they should apply now or later.

"Some students, however, may never be in a position to submit a very strong application to medical school, and those are the students I enjoy working with the most," he says. "Helping them to understand their core interests, talents and opportunities outside of becoming a physician is very rewarding for me, because being a physician is not for everyone, and there are a plethora of careers that a student may find even more rewarding once they begin to investigate them."

However, Dr. Louis Levitt, executive vice president and secretary of The Centers for Advanced Orthopaedics, suggests that his own life story of applying four times to medical school until he got in shows what is possible.

Levitt notes that he eventually graduated in the top 5% of his medical school class at Virginia Commonwealth University School of Medicine, which was previously known as the Medical College of Virginia. He also won admission to the Alpha Omega Alpha Honor Medical Society, a selective and prestigious club for high-achieving medical students, residents, faculty members and alumni.

"I'm at the end of my career at this point, but when I look back on it, I would never do anything different other than medicine," says Levitt, an associate professor of orthopedics at the George Washington University School of Medicine and Health Sciences and a clinical instructor at the Georgetown University School of Medicine.

"You know, every day, I go to work and I can make people feel better and have an impact daily on people's lives. ... If I had tried to do anything other than this, I would have been a miserable human being, I think. So ... my persistence paid off for me. It may not pay off for other people, but it certainly did for me."

Searching for a medical school? Get our complete rankings of Best Medical Schools.

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What Are Your Chances of Getting Into Medical School? - Yahoo News

Why I Want to Be a Doctor Now: Med Students Discuss What Makes Them Want to Help and Heal – Newswise

Students Write White Coat Ceremony Oath Pledging to Serve as Agents for Social Justice

*Students Available for Interviews*

Newswise (New York, NY October 15, 2020 - The White Coat ceremony represents a rite of passage, launching first-year medical students on their formal careers in a gathering of faculty, colleagues, and family. In this era of social distancing, the Icahn School of Medicine at Mount Sinais White Coat ceremony takes place via Zoom on Tuesday, October 13.

But why become a doctor now, in a pandemic, when providing care can be potentially life-threatening to the clinician? Incoming students describe what makes them want to help and heal, and the oath they have written togetherat this unprecedented time in the history of American medicineas a guide to their future careers as physicians.

Candida Damian, who is Black/Guamanian and was raised in Alabama, never went to the doctor as a young girl because her single mom could not afford health insurance. All I knew about doctors was what I saw on TV, she says. I wanted to work and care for patients at an intimate level. It was in nursing school that I gained the exposure I needed to realize that I not only wanted to change careers to become a doctor, but I needed to do it so I could provide the level of care necessary for my patients.

Candida says that inequities in health care have always been there but are just more visible now, making this a critical time to join the profession. My deepest ambition as a doctor is to ensure that everyone, no matter who they are, has access to health care. As a Black /Guamanian future physician, who will represent diverse and under-resourced communities, it will be my duty to use my voice to advocate for change and to remove the barriers that I experienced as a young girl," she says.

Stephen McCroskery suffered for years with untreated sleep apnea before it was noticed by his brother on a visit home from college. The diagnosis, delivered by a tactful physician, would set him on a path into medicine. The doctors style was so gentle, says Stephen. While I did have a weight problem, the way he suggested that I lose weight helped me understand my diagnosis and the need to lose the necessary weight to control the sleep apnea. It had been wreaking havoc in my life for years, he says.

Stephen begins medical school with a running start, having graduated from the Icahn School of Medicines Master of Science in Biomedical Science (MSBS) program. While studying for his Masters, he worked in the lab of Peter Palese, PhD, a world-renowned microbiologist who oversees a lab committed to understanding viruses, their makeup, and how they spread.

While working on a universal influenza vaccine, the lab has also pivoted to understanding the Sars-Cov2 virus and developing a vaccine candidate. We are hopeful it will go to clinical trials. One thing we like about this vaccine is that it would be manufactured in chicken eggs, making it much less expensive to produce and therefore more accessible to countries that are not as wealthy as the United States, he says. Unfortunately a lot of people dont believe in vaccines. In light of this, I want to advocate for science and medicine and give my patients the best information on which to make the best decisions for their health.

Jerrel Catlett says the pandemic served as a major turning point in his life and career. I would sayas an African Americanthe pandemic has made me acutely aware of how vulnerable my community is, he says. Teaming up with three other Icahn students, he developed an anti-racism discussion series open to faculty, physicians, and hospital administrators across the Mount Sinai Health System to engage in small group conversations focusing on how anti-Black biases and prejudices manifest in medical practice and research. I feel more empowered now because we are gaining the literacy and language to describe what is happening around us, and identifying ways to be a part of the solution.

He wants to be a physician-scientist in pediatric oncology. Prior to embarking on the MD program at the Icahn School of Medicine, he worked at the Broad Institute of MIT and Harvard, and Dana-Farber Cancer Institute. However, it was the young patients he met conducting research in childhood bone tumors who started him on a medical career. I was incredibly moved by the kids I met while shadowing at Dana-Farber, he says. The extent to which they seemed to be aware of the impact of their disease on themselves and their families at such a young age was heartbreaking, but they are among the strongest people I have ever met. Knowing them made me really want to help.

Calista Dominy represented one of 18 writing groups working together to write the oath to be recited by her classmates at the White Coat ceremony. Crafting the oath is an annual process to reflect the sentiments and promises of the class of 140 incoming students.

Her group wanted to focus on empathy and humility. We wanted to use the word ally to reflect that we as doctors must be on the same level with our patients, she says. Weaving into the oath a strong commitment to fighting the inequities that surround us became a collective priority. I think we all really feel an incredibly strong commitment to social justice as a collective group. This year, for the first time, the oath references current events, including police brutality.

The schools commitment to social advocacy was one of the prominent reasons she was drawn to Mount Sinai. My eyes have been open to several injustices as a woman who is half Filipina. In my search for a medical school, finding an environment committed to racial justice was extremely important. I am so happy to be at Mount Sinai now because the hospital and the school are really doing as much as they can to eradicate racism, especially in medicine, and especially now.

Suvruta Iruvanti works as a volunteer at Mount Sinais clinic for the uninsured, the East Harlem Health Outreach Partnership (EHHOP), helping patients who require specialized care or financial assistance navigate the hospital system. Removing barriers and helping under-resourced patients obtain care has long been a career priority. As an undergraduate pursuing simultaneous degrees in Molecular and Cell Biology and Business at the University of California, Berkeley, he led a team of students into the northern Himalayan region of India to set up a clinic that would provide dental care for rural residents, many of whom had never seen a dentist.

Having studied prostate and ovarian cancer at the Broad Institute, he is interested in the possibilities of medicine to uncover new treatments for patients with advanced stage diseases. The why in disease has always intrigued me and propelled me toward medicine to find answers, he says.

Suvruta, who took on the role of scribe in writing the school oath, says the writing process was remarkably smooth as groups came together to submit contributions, then collaborated on editing through remote tools. Zoom is definitely a different modality, but we are still moving at the same pace even though we are not physically together.

One of the positives of a virtual White Coat ceremony, he says, is that he can invite as many family members from as many far-flung locations as he wishes to witness his big moment, via Zoom.

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About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality carefrom prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty by U.S. News & World Report.

For more information, visithttps://www.mountsinai.orgor find Mount Sinai onFacebook,TwitterandYouTube.

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Why I Want to Be a Doctor Now: Med Students Discuss What Makes Them Want to Help and Heal - Newswise

Harvard Medical School Professor Lisa Iezzoni to speak at URI Oct. 27 on health care disparities and disability – URI Today

KINGSTON, R.I. October 16, 2020 Lisa Iezzoni, M.D., a professor of medicine at Harvard Medical School, will speak Tuesday, Oct. 27, as part of the University of Rhode Island Honors Colloquium, Challenging Expectations: Disability in the 21st Century.

Iezzoni, who is based at the Health Policy Research Center, Mongan Institute of Massachusetts General Hospital, will give the online lecture, Healthcare Disparities for People with Disability at 7 p.m.

The link to the lecture can be found on the day of the event in the colloquium schedule, next to Iezzonis name. The lecture is free and open to the public.

Her early career focused on risk adjustment methods for costs and clinical outcomes and assessing quality of care. She wrote and edited Risk Adjustment for Measuring Health Care Outcomes, now in its fourth edition.

Iezzoni has conducted numerous studies for the Agency for Healthcare Research and Quality, National Institutes of Health, the Medicare agency and private foundations. Since 1998, her research has focused on improving the experiences of and health care quality for adults with disabilities.

Her book, When Walking Fails, was published in 2003, and More Than Ramps: A Guide to Improving Health Care Quality and Access for People with Disabilities, co-authored with Bonnie L. ODay, appeared in 2006.

Iezzoni also spends much of her time advocating for people with disabilities. Representing the Boston Center for Independent Living, she chaired the Medical Diagnostic Equipment Accessibility Standards Advisory Committee for the U.S. Access Board from 2012 through 2013. Iezzoni is a member of the National Academy of Medicine in the National Academy of Sciences.

Gianna Carderelli, a University of Rhode public relations major and intern in its Department of Marketing and Communications, wrote this press release.

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Harvard Medical School Professor Lisa Iezzoni to speak at URI Oct. 27 on health care disparities and disability - URI Today

Michigan Medicine notifies patients of email information breach – University of Michigan Health System News

ANN ARBOR, Mich. Michigan Medicine is notifying 1062 patients about an email that may have exposed their email addresses and health information to others.

Emails containing information about an Inflammatory Bowel Disease event were sent to patients in late September without the blind copy function being used to hide email addresses, so patients email addresses were visible to all recipients.

The patient information involved is limited, as the email only included an email address and an invitation for the event. The data did not contain addresses, phone numbers, Social Security numbers, credit card, debit card or bank account numbers so the risk of identity theft occurring is extremely low.

General medical records were not in the information that was emailed.

As soon as Michigan Medicine learned of the error, no additional emails were sent. Separate emails were sent to explain the error, and included a request that the recipients delete the prior email.

Affected patients were mailed letters Oct. 16 notifying them of the breach.

Patient privacy is extremely important to us, and we take this matter very seriously. Michigan Medicine took steps immediately to investigate this matter and is implementing additional safeguards to reduce risk to our patients and help prevent recurrence, said Jeanne Strickland, Michigan Medicine chief compliance officer.

To prevent future errors like this, the department involved will be adopting different processes for sending emails to patients.

Michigan Medicine officials believe the risk of identity theft is low because of the limited information involved. However, it is always recommended to monitor patient insurance statements for any transactions related to care or services that have not actually been received. Patients were sent a list of suggested steps to protect against identity theft.

Affected Michigan Medicine patients are expected to receive letters in the mail notifying them of this incident within the next few days. Patients who have concerns or questions may call the University of Michigan IBD Program at 734-647-2964 between 8 a.m. and 5 p.m. or email debratan@med.umich.edu.About Michigan Medicine: At Michigan Medicine, we advance health to serve Michigan and the world. We pursue excellence every day in our three hospitals, 125 clinics and home care operations that handle more than 2.3 million outpatient visits a year, as well as educate the next generation of physicians, health professionals and scientists in our U-M Medical School.

Michigan Medicine includes the top ranked U-M Medical School and the University of Michigan Health System, which includes the C.S. Mott Childrens Hospital, Von Voigtlander Womens Hospital, University Hospital, the Frankel Cardiovascular Center and the Rogel Cancer Center. Michigan Medicines adult hospitals were ranked no. 11 in the nation by U.S. News and World Report in 2020-21 and C.S. Mott Childrens Hospital was the only childrens hospital in Michigan nationally ranked in all 10 pediatric specialties analyzed by U.S. News and World Report for 2020-21. The U-M Medical School is one of the nation's biomedical research powerhouses, with total research funding of more than $500 million.

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Michigan Medicine notifies patients of email information breach - University of Michigan Health System News

How UGA students are applying to grad schools amid COVID-19 – Red and Black

Seniors at the University of Georgia are gearing up to apply for graduate school programs as their final year on campus draws to a close. While this semester isnt what they thought it would look like, neither is the process of applying to postgraduate programs.

From law school and masters degree programs to physicians assistant school, UGA students are maneuvering their way through COVID-19s hurdles to continue their academic careers. With no certainty about fall 2021, applying to upper-level schools and programs has been more uncertain than ever.

UGA Graduate School DeanRon Walcott said the number of fall 2020 applications increased by 9%.

Walcott said changes were made to applications for COVID-19 based on the specific programs requirements.

For example, international students were permitted to submit final transcripts after registration, and some programs extended application deadlines, Walcott said. The popular language learning app Duolingo was added as an English proficiency test for international students as well, Walcott said.

Some graduate programs and schools have announced their plans for the return of students for fall 2021 while still keeping precautions in place due to the COVID-19 pandemic.

Some of the medical schools senior biology major Shea Fincher applied to will require faculty, staff, students and visitors to wear face coverings while inside campus facilities and buildings along with required social distancing inside each classroom.

Kassie Hogan, a senior majoring in biology and psychology, explained some of the major differences in applications this year as opposed to other years.

Normally schools require GRE scores, but this year none are, Hogan said. As for the lengthy interview process, Hogan said interviews will also likely be conducted over Zoom.

Some schools are waiving the Graduate Record Examination for summer and fall 2021 and or spring 2021 because of COVID-19 complications. Some of these schools include Auburn University, The University of Alabama and Florida State University, according to Study.com.

Jenna Swaboiwicz, a senior communication sciences and disorders major, also said the absence of a GRE requirement was the biggest change this year due to COVID-19. However, Swabowicz opted to take the GRE at home, a new option in the wake of the COVID-19 pandemic.

Having to take it at home with online proctoring software was completely new to me, and after the fact, having to find out which schools were still requiring it, which would consider it but not make it mandatory and which wouldn't even look at it presented a new boundary, Swaboiwicz said.

Swabowicz also said many schools held modified Zoom information sessions to promote their graduate programs. COVID aside, I think this was a really great way to get students across the country to learn about each program, Swabowicz said.

Fincher said that all of her interviews for medical school will be conducted online as opposed to normally traveling to schools for interviews.

Virtually attending interviews instead of traveling to schools helps my budget, but I believe virtual interviews can be a disadvantage in getting to know a person like you can during a normal interview process, Fincher said.

Similarly, Swabowicz said the process for choosing schools to apply to was very difficult without any in-person component of touring.

Deciding which schools to apply to without in-person information sessions and campus tours was definitely daunting, Swabowicz said.

Hogan said that the optional GRE test is the only lenient part of the application process this year as opposed to previous years.

I think it has been harder [to complete the application during COVID-19] because usually you can go to advisors or career centers and ask questions and even talk to your programs of interest, Hogan said.

Fincher said the medical school application was more difficult this year because of opportunities missed due to quarantine and COVID-19 precautionary measures.

I believe this application was harder amid the COVID-19 changes because different research and volunteering opportunities of mine were canceled or postponed over the spring until further notice, Fincher said.

This forced Fincher to find new non-contact volunteer opportunities to still have a competitive application for medical school.

Overall, I believe the application process has not changed in rigor, but instead it has adapted through the COVID-19 pandemic to better understand applicants during this stressful time, Fincher said.

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How UGA students are applying to grad schools amid COVID-19 - Red and Black

Medical researcher credits Rugby High with helping to shape career – Pierce County Tribune

Dr. Caleb Skipper poses for a photo in North Dakota Medicine, the University of North Dakotas School of Medicine and Health Sciences Fall 2020 magazine.

A 2005 Rugby High School graduate credits experiences from his hometown with shaping his work as a medical doctor and researcher.

Dr. Caleb Skipper and a team of University of Minnesota infectious disease researchers made news on the healthcare front last spring when they tested the effects of a controversial treatment for COVID-19.

Skipper said the idea to test hydroxychloroquine, a medication commonly used for malaria, on patients exposed to the novel coronavirus came to his team when they found themselves stranded in the United States and away from their work in Uganda.

When coronavirus hit, I had come back to the US for a routine medical conference, Skipper said. That week was the week everything shut down and everything changed. But, since we were (in the United States), my team actually had some infectious disease researchers who were all here, and our stuff was in Uganda, which was shut down like most of the world.

We asked ourselves, What can we contribute while were here in light of whats going on?' Skipper added.

Caleb Skippers senior photo appeared in Rugby High Schools 2005 yearbook.

So, we studied hydroxychloroquine. Youve probably heard of that. We were interested in it because as infectious disease doctors, thats a drug traditionally used to treat malaria, and we had some familiarity with it, Skipper said, noting he had been a part of a team in East Africa studying malaria.

There were some papers that had come out where, when they looked at it, at least in a test tube, the hydroxycholorquine had efficacy against the SARS COV-2 virus (a name for the virus that causes the disease known as COVID-19), Skipper said. It was very early on, and there were no treatments yet, so we rallied together and decided that we were going to launch a randomized clinical trial to study the hydroxychloroquine to see if that could be an efficacious treatment. We actually ended up turning our trial into three independent trials, each asking a different question but all using hydroxychloroquine.

We did try to set up trials to basically remove bias as much as possible. Thats what good scientists should do. We did randomized, double-blinded placebo trials. We actually gave our patients a placebo or hydroxychloroquine. They were blinded (didnt know what they were receiving), and we were blinded as well. Thats the most robust trial you can do to remove bias, Skipper added.

We found basically, in all three trials, looking at whether you can prevent getting the disease after youd been exposed to someone with it, called post-exposure prophylaxis, and another arm was, looking at once someone had gotten the virus, if you gave it early to them in the course, if it could mitigate the disease and prevent them from needing to go to the hospital and ICU.

Skipper said of the trials, We found hydroxychloroquine was no better than a placebo in doing that. Our randomized clinical trials failed to find a benefit.

My specific team are now not doing any active COVID research, Skipper said. Were back to doing HIV/AIDS research. Thats been restarted back in Uganda.

Skipper, whose father, Dr. Ronald Skipper serves as a surgeon for Heart of America Medical Clinic, said medicine has always figured prominently in his life.

Its definitely an influence, for sure. Growing up in Rugby, wed go to the grocery store and someone would come up to my dad and say, Dr. Skipper, thank you so much for helping me. So, growing up, I saw my dad was well appreciated and respected in the community and made an impact on people. That was attractive to me, Skipper said. That was definitely an influence.

An Ohio native, Skipper said, I consider myself being from Rugby because I spent all my formative years there fifth grade through high school.

Skipper said his time in Rugby shaped his life One hundred percent. Like I said, I feel like all my formation as a young man was in Rugby. So, between the different opportunities I had being involved in activities (had a benefit).

Its funny, he added. In a small town, there may not be as much of a breadth of opportunities as there are in a larger city but in some ways those opportunities are more available. There are only so many of you. Even if youre not good at sports, you can be on the teams. So, I have very fond memories of growing up in Rugby and going to school there, and the high school in particular.

Rugby Highs 2005 yearbook features Skipper on several pages; he served on the student council and participated on the schools Science Olympiad team.

I remember Jan Hagen, Skipper said. She was one of the science teachers. She in particular was a really key figure in my interest in the sciences and ultimately going to medical school.

But I think there are a bunch of people in Rugby (who were influential), Skipper added.

After graduating from RHS, Skipper studied at the University of North Dakota, moving to Ethiopia for a year after receiving his bachelors degree.

But I think what really got me particularly into the infectious diseases piece was after college, I went to Ethiopia for a year, kind of out in the middle of nowhere, working on some malaria projects, Skipper said.

Thats what cemented my interest in medicine, but it kind of shifted my focus into infectious diseases, he added.

Skipper said hes returned to his work on HIV and AIDS in Africa now. However, he still thinks of his youth in Rugby often. I feel like Rugby and my high school experience were very pro-family impactful on me becoming the man I am today, he said.

Skipper said he still follows stories about the global COVID-19 pandemic, too.

In Rugby, things seem pretty stable there, he said, referring to the communitys health. But in North Dakota as a whole, the coronavirus isnt being kept well-controlled there. I think, in a small town, people sometimes have perspectives. What applies to a larger city doesnt apply to a small town, Skipper added. In North Dakota, people are very independent, and in my opinion, I appreciate that independence. But at the same time, sometimes Mother Nature throws a curve ball bigger than politics or bigger than what you think the world should be.

I would encourage people to take COVID-19 seriously and protect their neighbors by wearing masks and doing small things, he added. I hope people basically look at this as something they have a part to play in as well. They can do the small things to help each other out.

Its such a small inconvenience to potentially provide some benefit, you know? Skipper added.

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Medical researcher credits Rugby High with helping to shape career - Pierce County Tribune

What is osteopathic medicine? A D.O. explains – The Conversation US

When President Trump was diagnosed with COVID-19, many Americans noticed that his physician had the title D.O. stitched onto his white coat. Much confusion ensued about doctors of osteopathic medicine. As of a 2018 census, they made up 9.1% of physicians in the United States. How do they fit into the broader medical field?

Andrea Amalfitano is a D.O. and dean of the Michigan State University College of Osteopathic Medicine. He explains some of the foundations of the profession and its guiding principle: to use holistic approaches to care for and guide patients. And dont worry, yes, D.O.s are real doctors and have full practice rights across the U.S.

In the years after the Civil War, without antibiotics and vaccines, many clinicians of the day relied on techniques like arsenic, castor oil, mercury and bloodletting to treat the ill. Unsanitary surgical practices were standard. These treatments promised cures but often led to more sickness and pain.

In response to that dreadful state of affairs, a group of American physicians founded the osteopathic medical profession. They asserted that maintaining wellness and preventing disease was paramount. They believed that preserving health was best achieved via a holistic medical understanding of the individual patients, their families and their communities in mind, body and spirit. They rejected reductionist interactions meant to rapidly address only acute symptoms or problems.

They also embraced the concept that the human body has an inherent capacity to heal itself decades before the immune systems complexities were understood and called for this ability to be respected and harnessed.

Doctors of osteopathic medicine D.O.s, for short can prescribe medication and practice all medical and surgical specialties just as their M.D. counterparts do. Because of the focus on preserving wellness rather than waiting to treat symptoms as they arise, more than half of D.O.s gravitate to primary care, including family practice and pediatrics, particularly in rural and underserved areas.

D.O. training embraces the logic that understanding anatomic structures can allow one to better understand how they function. For example, alongside contemporary medical and surgical preventive and treatment knowledge, all osteopathic physicians also learn strategies to treat musculoskeletal pain and disease. These techniques are known as manual medicine, or osteopathic manipulative treatment (OMT). They can provide patients an alternative to medications, including opioids, or invasive surgical interventions.

D.O.s pride themselves on making sure their patients feel theyre treated as a whole person and not simply reduced to a symptom or blood test to be rapidly dealt with and then dismissed. We say we aspire to care for people, not patients, with an empathetic attitude and an emphasis on making sure those closest to those in their care, such as family and loved ones, as well as other social factors, are all taken into account.

The osteopathic philosophy around prevention and wellness might seem like common sense today, but it was revolutionary. Aspects of osteopathic medicine, including the use of alternative therapies such as OMT, were originally met with skepticism or outright hostility by some medical doctors who questioned their scientific bases. Indeed, in 1961, the American Medical Associations code of ethics declared it unethical for an M.D. physician to professionally associate with doctors of osteopathy.

So with the guidance of the American Osteopathic Association, D.O.s created their own D.O. hospitals, residency and fellowship programs, and four-year D.O. degree-granting medical schools. Instruction around the current science of health and illness is similar between D.O.s and M.D.s its the philosophical delivery of that knowledge thats different.

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Certainly a holistic approach to health is no longer exclusive to D.O.s. In fact, many M.D., nursing, physician assistant and other health professional schools now embrace parts of it as they deliver care. And now, D.O.s and M.D.s often work side by side in medical settings across the country. More recently, the AMA has recently recognized the D.O. licensing exams as equivalent to the exams M.D.s take. D.O.s compete for the same training residencies as M.D.s and, eventually, the same jobs.

Osteopathic medicine is now one of the fastest-growing health professions, with over 150,000 D.O.s and D.O. medical students practicing in the U.S. and internationally. One in four newly minted U.S. physicians in the class of 2019 graduated from an osteopathic medical school.

Osteopathic medicine is now a mainstay of contemporary medical practice, with D.O.s active in all aspects of the nations health care systems.

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What is osteopathic medicine? A D.O. explains - The Conversation US

Effect on endometriosis recurrence with postoperative hormonal suppression – Contemporary Obgyn

Postoperative hormonal suppression had a statistically significant effect on reducing endometriosis recurrence and improving pain, according to a systematic review and meta-analysis published in the journal Human Reproduction Update.

As surgeons, our primary goal is to make patients feel better and we often accomplish this by surgically treating endometriosis, said co-author Ally Murji, MD, MPH, an associate professor of ob/gyn at the University of Toronto and Mount Sinai Hospital in Toronto, Canada. However, it is especially disheartening, despite our best surgical efforts, when disease recurs and patients relapse.

The authors sought to evaluate whether postoperative hormonal suppression decreases disease recurrence, compared with placebo/expectant management.

MEDLINE, Embase, Cochrane CENTRAL and Web of Science databases were searched from inception to March 2020 for randomized clinical trials (RCTs) and prospective observational cohort studies of premenopausal women undergoing conservative surgery and initiating hormonal suppression within 6 weeks postoperatively with one of the following medical therapies: combined hormonal contraceptives, progestins, levonorgesterel-releasing intrauterine system (LNG-IUS) and gonadotropin-releasing hormone (GnRH) agonists.

The review consisted of 17 studies (13 RCTs and 4 cohort studies), totaling 2,137 patients: 1,189 receiving postoperative suppression and 948 controls.

The mean follow-up ranged from 12 to 36 months, with outcomes assessed at a median of 18 months postoperatively.

Among 14 studies (11 RCTs, 3 cohort studies; 1,766 patients total), there was a significantly decreased risk of endometriosis recurrence in patients receiving postoperative hormonal suppression compared with expectant management/placebo: relative risk (RR) 0.41; 95% confidence interval (CI): 0.26 to 0.65.

However, when we limited the analysis to only RCTs, we found that the risk of postoperative endometriosis recurrence was consistently decreased with hormonal suppression, Dr. Murji told Contemporary OB/GYN.

In addition, among seven studies (6 RCTs, 1 cohort study; 652 patients total), patients receiving postoperative hormonal suppression achieved significantly lower pain scores compared with controls: standard mean difference (SMD) -0.49; 95% CI: -0.91 to -0.07.

Our review provides new evidence that postoperative hormonal suppression decreases endometriosis recurrence and pain, Dr. Murji said. This contradicts the last Cochrane review on the topic.

Furthermore, although there was significant heterogeneity in the studies included in the review, I am confident in the results, he said. We found that there is only a 4% probability that any future RCT would contradictour findings.

Dr. Murji was surprised by the magnitude of the effect. As few as eight women would need to be treated with postoperative hormonal suppression for at least 6 months to prevent one endometriosis recurrence, he said.

Dr. Murji said it is essential that clinicians educate their patients that endometriosis is a chronic condition and that surgery is not a panacea. Extensive patient counseling before surgery is necessary to educate patients and manage their expectations, according to Dr. Murji. For patients not seeking to conceive immediately after surgery, I offer hormonal suppression, he said. The plan for postsurgical prevention is also formalized preoperatively.

Due to the recent COVID-19 pandemic-related surgical delays, there is increased opportunity to help patients find the ideal medical treatment option that aligns with their individual needs so as to bridge patients to their surgery and thereafter, he said.

Dr. Murji and his colleagues have found that hormonal contraceptives, progestins, the LNG-IUS and a GnRH agonists are all consistently effective in decreasing pain and disease recurrence.

In particular, the LNG-IUS, which can be inserted under laparoscopic visualization at the time of surgery, avoids some of the issues related to discomfort/placement and provides excellent long-term suppression, Dr. Murji said.

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Dr. Murji serves on the speakers bureau/advisory boards of Abbvie, Allergan, Bayer, Hologic, and Pfizer.

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Effect on endometriosis recurrence with postoperative hormonal suppression - Contemporary Obgyn

Whats At Stake This November And How You Can Get Out The Vote – Forbes

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Unless youve been living under a rock for the last 6 months, you likely know that we have an important presidential election coming up on Tuesday, November 3rd. We are constantly being inundated with political ads and told about the important issues. But with all the noise, it can be difficult to understand what is truly at stake.

I recently interviewed Kelley Robinson, who is currently the Executive Director ofPlanned Parenthood Action Fundand as the Vice President of Advocacy and Organizing atPlanned Parenthood Federation of America. We talked about what is at stake with this 2020 presidential election, especially related to our healthcare, finances, reproductive rights, and beyond.

So, whats really at stake for all of us this November? Here are just a few things:

Since the Affordable Care Act was signed into law in 2010, Republicans in Congress have been trying to have it overturned. It has repeatedly been upheld by the Supreme Court, but that hasnt stopped the Republicans from continuing to try to get rid of it. In case you dont remember (since its been over a decade), before the Affordable Care Act was law of the land, health insurance was only available through your employer or from expensive private insurance companies. Pre-existing conditions (which can be pretty much anything) were not covered by insurance, so you could be denied coverage if you have any history with illness or injury, which most of us have. Children would also get kicked off their parents insurance when they turned 18 - now, they can stay on until they are 26 years old. We are currently in the middle of a global pandemic, which means health care coverage is more important than ever. And remember, medical costs are the number one cause of bankruptcy in the United States. If thats still true even with the Affordable Care Act in place, imagine how much worse things will get without it.

Another issue that Republicans have been relentless about is to make abortion illegal across the board in the United States. Despite what you might think based on the political rhetoric, the majority of Americans actually support the decision in Roe v. Wade. In fact, 61% of Americans say that abortion should be legal in all or most cases. Regardless, there is legislation introduced seemingly everyday that seeks to restrict abortion access and reproductive rights overall. Many of these bills are already being challenged and are set to be heard by the Supreme Court any day. I will discuss what is at stake when it comes to the Supreme Court further down in this piece, but we need politicians that will protect reproductive health and access.

A number of studies have established connections between abortion access and economic outcomes. And it seems like common sense; if you have control over your reproduction, you will have more control over and access to financial security. This paper from the Institute for Womens Policy Research outlines the ways that reproductive rights influences educational attainment, workforce participation, and more.

In September, there was widespread flash flooding in my town. Many of my neighbors homes and cars were damaged or destroyed. On the same day, wildfires were raging in Northern California. These are just two examples of ways climate change will continue to impact our lives. And it will get worse if we dont mitigate the damage. When it comes to climate change, one political party denies that it is a problem or they say it is not caused by human behaviors. The other party acknowledges that climate change is a massive problem and accepts the proven science that shows what is causing it - burning fossil fuels such as oil, gas, and coal. We need a national commitment to fighting climate change and a strategy for embracing clean energy solutions. Otherwise, people will continue to suffer and die in rampant wildfires, floods, stronger and more frequent storms, and droughts.

If youre paying attention this week, you know that the Senate is currently holding hearings regarding the Supreme Court nominee Amy Coney Barrett. Regardless of your political views, this process is being forced through, much faster than ever before, while were in the middle of a pandemic and just weeks away from a presidential election. It makes it impossible for our voices to be heard and impossible for the necessary vetting to be done in time. But on top of that, this nominee is someone who is seemingly against any and all progressive strides weve made in the past several decades.

This week, she even said she could not immediately say whether or not she thinks Medicare is constitutional. Medicare is massively important for Americans over the age of 65. People who are retired or living on a fixed income would not have many options for their health care if Medicare were to be somehow eliminated in the future. Plus, she is on record opposing Roe v. Wade and the Affordable Care Act. And remember, a Supreme Court appointment is a lifetime job. Coney Barrett is only 48 years old. She could be on the Court for at least the next 40 years.

All of that being said, its easy to feel hopeless and overwhelmed when you consider everything that is at stake right now. And there are many things at stake beyond what I outlined above, including LGBTQ+ rights and racial equality. But in my conversation with her, Kelley Robinson said something incredibly inspiring: This is not a moment to be afraid. This is a moment for us to lean in and know that we've got some important decisions to make to ensure that we achieve change that makes lives better at the end of the day.

There are things we can all do to make a difference during this election and ensure that our trajectory starts going in the right direction. So, what are some of those things?

Even if you voted in the last election, its important that you make sure that you are registered to vote at your current address, under your current name. You never know if the voter rolls in your state have been purged, so err on the side of caution and double check your voter registration. Visit vote.org to see if your voter registration is up to date. To find out if you still have time to register to vote in your state, go here.

Its much easier to follow through with something if you have thought out and planned out what you are actually going to do. Whether youre requesting a mail-in ballot, voting early, or showing up on Election Day, its important that you identify that plan now. That way, you can rearrange your schedule or take other actions that will allow voting to be easier. For me, my original plan was to vote by mail, but my ballot seems to be lost in the mail somewhere! So my backup plan, after speaking to the state board of elections, is to vote early, in-person, via a provisional ballot. Once they confirm that I didnt send in my mail-in ballot, they will count my in-person vote.

Whats your plan?

As I said above, its easier to follow through with something if there is a plan in place. That applies to the people you know too! So start asking your friends and family members what their voting plan is. If they dont have an answer right away, ask them if they need help or suggestions. Check back in later if they need a little time to think about it.

Everything is more fun with a buddy. Of course, during a global pandemic, you might not be able to drive together, and you might have to keep your physical distance, but get a friend to join you while you vote! You can meet up at the polls at the same time or you can even vote together from afar, if your polling places are different.

We are still in the midst of a global pandemic, even if a major presidential election is coming up. If youre worried about staying safe while still getting out the vote, consider voting early. In many states, you can still request a mail-in or absentee ballot so that you can vote by mail. If youre uncomfortable with that, or if you already missed the deadline, many states also allow for early voting. Find out if and when early voting begins in your state and make a plan to get there to vote. And dont forget to wear your mask and keep your physical distance from others.

Already registered to vote and have a voting plan, but you still want to be involved? You can volunteer with an organization that fights for the things you most believe in. For example, I have been volunteering to do text banking with RAICES, which is an immigrants rights organization. There are many other organizations doing the same to get out the vote and encourage folks to vote for human rights, immigrant rights, reproductive rights, and more.

Lets do this! Make sure you get out and vote on November 3rd!

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Whats At Stake This November And How You Can Get Out The Vote - Forbes

A multimillennial climatic context for the megafaunal extinctions in Madagascar and Mascarene Islands – Science Advances

Madagascar and the Mascarene Islands of Mauritius and Rodrigues underwent catastrophic ecological and landscape transformations, which virtually eliminated their entire endemic vertebrate megafauna during the past millennium. These ecosystem changes have been alternately attributed to either human activities, climate change, or both, but parsing their relative importance, particularly in the case of Madagascar, has proven difficult. Here, we present a multimillennial (approximately the past 8000 years) reconstruction of the southwest Indian Ocean hydroclimate variability using speleothems from the island of Rodrigues, located 1600 km east of Madagascar. The record shows a recurring pattern of hydroclimate variability characterized by submillennial-scale drying trends, which were punctuated by decadal-to-multidecadal megadroughts, including during the late Holocene. Our data imply that the megafauna of the Mascarenes and Madagascar were resilient, enduring repeated past episodes of severe climate stress, but collapsed when a major increase in human activity occurred in the context of a prominent drying trend.

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A multimillennial climatic context for the megafaunal extinctions in Madagascar and Mascarene Islands - Science Advances

Global Biologic Medication in COVID-19 Market 2020 by Company, Regions, Type and Application, Forecast to 2025 – re:Jerusalem

Global Biologic Medication in COVID-19 Market added by MarketQuest.biz provides a basic overview of the industry including definitions, classifications, applications, and industry chain structure. The report compiled and organized is a visionary output aimed at guiding report readers by offering high-end growth prospects about the market. The report primarily focuses on the market trends, demand spectrum, geographical opportunities, and contributions by prominent industry share contenders, future prospects of this industry over the forecast period from 2020 to 2025. The report furnishes with market size, market share estimates, information of drivers, market constraints, and discussion of key developments in the global Biologic Medication in COVID-19 industry.

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The report gives statistical as well as other types of analysis of leading manufacturers in the global Biologic Medication in COVID-19 market. It assesses each and every player studied in the report on the basis of the main business, gross margin, revenue, sales, price, competitors, manufacturing base, product specification, product application, and product category. In addition, the report incorporates competitive situations and trends, expansions, merger and acquisition deals, and other subjects. It also shows how different companies are progressing in the global market in terms of revenue, production, sales, and market share.

The well-established players in the market are: Roche, Regeneron Pharmaceuticals, Merck, Sanofi, Biogen, Novartis, Junshi Biosciences, Shutaishen, Bayer, Vir Biotech, Anke Biotechnology, OncoImmune

The breakdown of all regional markets by country and split of major national markets by product type and application over the study years are also included. The study offers guidance to help investors & stockholders identify emerging opportunities, manage and minimize the risks, develop appropriate business models, and make wise strategies and decisions. The report evaluates key global Biologic Medication in COVID-19 market features, including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, market share, CAGR, and gross margin.

Market by Product: This section carefully analyzes all product segments of the global market. Based on product type, the global market is segmented into the following sub-markets with annual for 2020-2025 included in each section: Neutralizing Antibodies, Anti-inflammatory Drugs

Market by Application: Here, various application segments of the global market are taken into account for the research study. Based on application, the global market is segmented into the following sub-markets with annual revenue for 2020-2025 included in each section: COVID-19, Influenza, Malaria, Others

Get COVID-19 Full Report Analysis: https://www.marketquest.biz/report/24106/global-biologic-medication-in-covid-19-market-2020-by-company-regions-type-and-application-forecast-to-2025

Geographically, the following regions together with the listed national/local markets are fully investigated:

North America (United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia)

South America (Brazil, Argentina, Colombia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

This Market Research Report Encloses Importance On:

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This report can be customized to meet the clients requirements. Please connect with our sales team (sales@marketquest.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Biologic Medication in COVID-19 Market 2020 by Company, Regions, Type and Application, Forecast to 2025 - re:Jerusalem

Where Does AnaptysBio Inc (ANAB) Stock Fall in the Biotechnology Field? – InvestorsObserver

AnaptysBio Inc (ANAB) is around the bottom of the Biotechnology industry according to InvestorsObserver. ANAB received an overall rating of 21, which means that it scores higher than 21 percent of all stocks. AnaptysBio Inc also achieved a score of 10 in the Biotechnology industry, putting it above 10 percent of Biotechnology stocks. Biotechnology is ranked 27 out of the 148 industries.

Finding the best stocks can be tricky. It isnt easy to compare companies across industries. Even companies that have relatively similar businesses can be tricky to compare sometimes. InvestorsObservers tools allow a top-down approach that lets you pick a metric, find the top sector and industry and then find the top stocks in that sector.

These rankings allows you to easily compare stocks and view what the strengths and weaknesses are of a given company. This lets you find the stocks with the best short and long term growth prospects in a matter of seconds. The combined score incorporates technical and fundamental analysis in order to give a comprehensive overview of a stocks performance. Investors who then want to focus on analysts rankings or valuations are able to see the separate scores for each section.

AnaptysBio Inc (ANAB) stock is trading at $23.80 as of 11:03 AM on Friday, Oct 16, an increase of $1.85, or 8.45% from the previous closing price of $21.94. The stock has traded between $22.00 and $24.44 so far today. Volume today is less active than usual. So far 187,181 shares have traded compared to average volume of 318,777 shares.

Click Here to get the full Stock Score Report on AnaptysBio Inc (ANAB) Stock.

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Where Does AnaptysBio Inc (ANAB) Stock Fall in the Biotechnology Field? - InvestorsObserver

Is Selecta Biosciences Inc (SELB) the Top Pick in the Biotechnology Industry? – InvestorsObserver

Selecta Biosciences Inc (SELB) is near the middle in its industry group according to InvestorsObserver. SELB gets an overall rating of 48. That means it scores higher than 48 percent of stocks. Selecta Biosciences Inc gets a 51 rank in the Biotechnology industry. Biotechnology is number 27 out of 148 industries.

Trying to find the best stocks can be a daunting task. There are a wide variety of ways to analyze stocks in order to determine which ones are performing the strongest. Investors Observer makes the entire process easier by using percentile rankings that allows you to easily find the stocks who have the strongest evaluations by analysts.

This ranking system incorporates numerous factors used by analysts to compare stocks in greater detail. This allows you to find the best stocks available in any industry with relative ease. These percentile-ranked scores using both fundamental and technical analysis give investors an easy way to view the attractiveness of specific stocks. Stocks with the highest scores have the best evaluations by analysts working on Wall Street.

Selecta Biosciences Inc (SELB) stock is trading at $2.30 as of 9:46 AM on Friday, Oct 16, a rise of $0.19, or 8.79% from the previous closing price of $2.11. The stock has traded between $2.20 and $2.31 so far today. Volume today is below average. So far 223,208 shares have traded compared to average volume of 2,413,171 shares.

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Is Selecta Biosciences Inc (SELB) the Top Pick in the Biotechnology Industry? - InvestorsObserver

Should You Buy Amicus Therapeutics, Inc. (FOLD) in Biotechnology Industry? – InvestorsObserver

The 63 rating InvestorsObserver gives to Amicus Therapeutics, Inc. (FOLD) stock puts it near the top of the Biotechnology industry. In addition to scoring higher than 76 percent of stocks in the Biotechnology industry, FOLDs 63 overall rating means the stock scores better than 63 percent of all stocks.

Trying to find the best stocks can be a daunting task. There are a wide variety of ways to analyze stocks in order to determine which ones are performing the strongest. Investors Observer makes the entire process easier by using percentile rankings that allows you to easily find the stocks who have the strongest evaluations by analysts.

Our proprietary scoring system captures technical factors, fundamental analysis and the opinions of analysts on Wall Street. This makes InvestorsObservers overall rating a great way to get started, regardless of your investing style. Percentile-ranked scores are also easy to understand. A score of 100 is the top and a 0 is the bottom. Theres no need to try to remember what is good for a bunch of complicated ratios, just pay attention to which numbers are the highest.

Amicus Therapeutics, Inc. (FOLD) stock is trading at $16.99 as of 10:56 AM on Friday, Oct 16, a gain of $0.05, or 0.27% from the previous closing price of $16.95. Volume today is 1,514,519 compared to average volume of 1,983,887. The stock has traded between $16.57 and $17.67 so far today.

Click Here to get the full Stock Score Report on Amicus Therapeutics, Inc. (FOLD) Stock.

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Should You Buy Amicus Therapeutics, Inc. (FOLD) in Biotechnology Industry? - InvestorsObserver

Agriculture Biotechnology Market Forecasts 2020-2026 : Growth Analysis By Key Drivers, Regions, Sorts and Applications – PRnews Leader

The recent report titled Global Agriculture Biotechnology Market Size, Status and Forecast 2020-2026 offered by Researchmoz.us, comprises of a comprehensive investigation into the geographical landscape, industry size along with the revenue estimation of the business. Additionally, the report also highlights the challenges impeding market growth and expansion strategies employed by leading companies in the Agriculture Biotechnology market.

This is the most recent report inclusive of the COVID-19 effects on the functioning of the market. It is well known that some changes, for the worse, were administered by the pandemic on all industries. The current scenario of the business sector and pandemics impact on the past and future of the industry are covered in this report.

Grab A Free Sample Copy of the Agriculture Biotechnology Market Report

In market segmentation by manufacturers, the report covers the following companies : ADAMA Agricultural Solutions, Vilmorin, Bayer, Biocentury Transgene, Certis, DowDuPont, Eurofins, Evogene, Global Bio-chem Technology, Syngenta, KWS Saat, Marina Biotech, Monsanto and among others.

Exploring Growth Rate Over a Period:

Business owners looking to scale up their business can refer this report that contains data regarding the rise in sales within a given consumer base for the forecast period, 2020 to 2026. Product owners can use this information along with the driving factors such as demographics and revenue generated from other products discussed in the report to get a better analysis of their products and services. Besides, the research analysts have compared the market growth rate with the product sales to enable business owners to determine the success or failure of a specific product or service.

Agriculture Biotechnology Market is segmented as below:

Analysis by Application:

Analysis by Product Type:

Global Agriculture Biotechnology Market Report 2020 Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Agriculture Biotechnology industry.

The Report at a Glance

The Agriculture Biotechnology market report focuses on the economic developments and consumer spending trends across different countries for the forecast period 2020 to 2026. The research further reveals which countries and regions will have a better standing in the years to come. Apart from this, the study talks about the growth rate, market share as well as the recent developments in the Agriculture Biotechnology industry worldwide. Besides, the special mention of major market players adds importance to the overall market study.

Market segment by Region/Country including:

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The research provides answers to the following key questions:

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To summarize, the global Agriculture Biotechnology market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Agriculture Biotechnology Market Forecasts 2020-2026 : Growth Analysis By Key Drivers, Regions, Sorts and Applications - PRnews Leader

Aro Biotherapeutics Appoints Biotechnology Executive Dr. Christopher Mirabelli to its Board of Directors and Nucleic Acid Therapeutics Expert Dr….

Oct. 13, 2020 12:00 UTC

PHILADELPHIA--(BUSINESS WIRE)-- Aro Biotherapeutics today announced the appointments of Christopher K. Mirabelli, Ph.D., to its Board of Directors and Masad J. Damha, Ph.D., to its Scientific Advisory Board. Drs. Mirabelli and Damha will provide strategic and scientific counsel on the development of novel Centyrin-RNA therapeutic candidates.

We are excited to welcome Chris, a well-recognized leader in drug development, to our Board of Directors. As the founder of multiple successful biotechnology companies, and an industry veteran with demonstrated experience in the development of new therapies, his insight and guidance will be invaluable as we advance the development of our pipeline of Centyrin-based therapeutic candidates, said Susan Dillon, Ph.D., Co-Founder and Chief Executive Officer of Aro.

Dr. Mirabelli has spent over 35 years in the pharmaceutical and biotechnology industries as a research scientist, senior executive, and venture capital investor. Currently, he is a managing director of the venture capital firm HealthCare Ventures. Dr. Mirabelli is currently Chairman of the Board of Directors of Leap Therapeutics, where he was the Chief Executive Officer from its founding in 2015 until 2020. Previously, Dr. Mirabelli was Chief Executive Officer and Chairman of the Board of Directors of LeukoSite from its founding in 1993 until its acquisition by Millennium Pharmaceuticals in 1999. Dr. Mirabelli was also a Co-Founder of Ionis Pharmaceuticals. He began his industry career in R&D at SmithKline & French Laboratories, and earned his Ph.D. in Molecular Pharmacology from Baylor College of Medicine and his B.S. in Biology from State University of New York (SUNY) at Fredonia.

I am looking forward to serving on Aros Board of Directors and working with Sue and her team to further advance their proprietary drug-targeting technology, commented Dr. Mirabelli. The use of antibodies to target drugs to sites of disease in patients has many limitations. Aros novel approach to overcoming these barriers is unique, and Im excited to contribute to the continued development of their pipeline of next-generation biotherapeutic candidates.

We are pleased to have Masad join Aros Scientific Advisory Board. His work in nucleic acid drug discovery and development has been at the forefront of oligonucleotide research, and his scientific insights will be instrumental as we continue to leverage the promise of Centyrins to achieve new therapeutic mechanisms of action, said Karyn ONeil, Ph.D., Co-Founder and Chief Scientific Officer of Aro.

Dr. Damha is a Distinguished James McGill Professor of Chemistry at McGill University. His research group focuses on synthesis and structural analyses of chemically modified oligonucleotides directed toward biomedical and diagnostic applications. His 200+ publications and dozens of issued patents have been widely cited and used in both fundamental sciences and oligonucleotide-based therapeutic applications. Dr. Damha is the recipient of several awards from the Canadian Society for Chemistry, the Queen Elizabeth II Diamond Jubilee Medal (Governor General of Canada), and McGills Fessenden Professorship in Science Innovation. He is currently President of the International Society of Nucleosides, Nucleotides, Nucleic Acids, and he has served as President of the Oligonucleotide Therapeutics Society. Dr. Damha was awarded a Ph.D. in Organic Chemistry and B.Sc. in Chemistry from McGill University.

Dr. Damha commented, I am very pleased to join Aro Biotherapeutics Scientific Advisory Board and contribute to the development of innovative therapies that enable efficient and specific delivery of nucleic acid conjugates that address important disease targets.

About Aro Biotherapeutics

Aro is a biotechnology company focused on the research and development of a new generation of protein biologics called Centyrins. The company is developing a wholly-owned pipeline of Centyrins and is working with leaders in the industry on leveraging Centyrins for tissue-specific targeting of therapeutics, including nucleic acid drugs for a diverse set of diseases. For more information, visit http://www.arobiotx.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20201013005040/en/

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Aro Biotherapeutics Appoints Biotechnology Executive Dr. Christopher Mirabelli to its Board of Directors and Nucleic Acid Therapeutics Expert Dr....

Marine Biotechnology Market 10-year Forecast and Trends Analysis Research Report – The Think Curiouser

This report also researches and evaluates the impact of Covid-19 outbreak on the Marine Biotechnology industry, involving potential opportunity and challenges, drivers and risks. We present the impact assessment of Covid-19 effects on Marine Biotechnology and market growth forecast based on different scenario (optimistic, pessimistic, very optimistic, most likely etc.).

Global Marine Biotechnology Market Overview:

The research report, titled [Global Marine Biotechnology Market 2020 by Company, Regions, Type and Application, Forecast to 2025], presents a detailed analysis of the drivers and restraints impacting the overall market. Analysts have studied the key trends defining the trajectory of the market. The research report also includes an assessment of the achievements made by the players in the global Marine Biotechnology market so far. It also notes the key trends in the market that are likely to be lucrative. The research report aims to provide an unbiased and a comprehensive outlook of the global Marine Biotechnology market to the readers.

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Global Marine Biotechnology Market: Segmentation

For clearer understanding of the global Marine Biotechnology market, analysts have segmented the market. The segmentation has been done on the basis of application, technology, and users. Each segment has been further explained with the help of graphs figures. This breakdown of the market gives the readers an objective view of the global Marine Biotechnology market, which is essential to make sound investments.

The major players profiled in this report include:Aker BioMarineBASFCP KelcoCyanotech Lonza Group

To understand the changing political scenario, analysts have regionally segmented the market. This gives an overview of the political and socio-economic status of the regions that is expected to impact the market dynamic.

Global Marine Biotechnology Market: Research Methodology

To begin with, the analysis has been put together using primary and secondary research methodologies. The information has been authenticated by market expert through valuable commentary. Research analysts have also conducted exhaustive interviews with market-relevant questions to collate this research report.

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Global Marine Biotechnology Market: Competitive Rivalry

The research report also studied the key players operating in the global Marine Biotechnology market. It has evaluated and elucidated the research and development statuses of these companies, their financial outlooks, and their expansion plans for the forecast period. In addition, the research report also includes the list of strategic initiatives that clearly explain the achievements of the companies in the recent past.

The end users/applications and product categories analysis:On the basis of product, this report displays the sales volume, revenue (Million USD), product price, market share and growth rate of each type, primarily split into-General Type

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate of Marine Biotechnology for each application, including-Marine

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Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Marine Biotechnology market

Chapter 2: Evaluating the leading manufacturers of the global Marine Biotechnology market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Marine Biotechnology market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

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Marine Biotechnology Market 10-year Forecast and Trends Analysis Research Report - The Think Curiouser

Neurelis Announces Four Poster Presentations For The Joint Meeting Of The International Child Neurology Association And Child Neurology Society -…

SAN DIEGO, Oct. 16, 2020 /PRNewswire/ -- Neurelis, Inc., announced today the company has four posters being presented at the 16th annual International Child Neurology Association Congress/49th annual Child Neurology Society Meeting. Due to the COVID-19 pandemic, posters are available online during the organizations' virtual meetings.

Neurelis Chief Medical Officer Enrique Carrazana, M.D., said the poster presentations continue to validate the safety, pharmacokinetics, and tolerability of VALTOCO (diazepam nasal spray) in children with epilepsy aged 6 and older. VALTOCO was approved by the U.S. Food and Drug Administration (FDA) on January 10, 2020, for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in adult and pediatric patients 6 years of age and older. In its approval, the FDA also granted VALTOCO 7 years of Orphan Drug Exclusivity. The FDA recognized VALTOCO's intranasal route of administration as clinically superior to the previously approved standard-of-care treatment (a rectal gel formulation of diazepam) as part of the Orphan Drug Exclusivity designation.

"The data continue to demonstrate that VALTOCO is an important treatment option for children with epilepsy suffering from seizure clusters,"Dr. Carrazana said.

Adrian L. Rabinowicz, M.D., Senior Vice President of Clinical Development and Medical Affairs, said, "It's important to note that similar to what we have seen in adults, a single dose of VALTOCO was used in 88 percent of seizure episodes in children studied. This gives physicians and parents confidence that VALTOCO has a sustained response."

The details for the poster presentations are as follows and are available online here; type VALTOCO in search bar to view.

Abstract: Time to Second Doses in Children With Epilepsy Treated With Valtoco (Diazepam Nasal Spray): Interim Subgroup Results From a Phase 3, Open-Label, Repeat Dose Safety Study

Abstract: Safety of Valtoco (NRL-1; Diazepam Nasal Spray) in Children With Epilepsy: Updated Interim Subgroup Results From a Phase 3, Open-Label, Repeat Dose Safety Study

Abstract: Importance of Seizure Time of Day in Children With Epilepsy Treated With Valtoco (Diazepam Nasal Spray): Interim Subgroup Results From a Phase 3, Open-Label, Repeat Dose Safety Study

Abstract: Valtoco (Diazepam Nasal Spray) in Children With Epilepsy Aged 6-11 Years: Interim Subgroup Results By Frequency of Usage From a Phase 3, Open-Label, Repeat Dose Safety Study

About VALTOCO

VALTOCO is a proprietary formulation of diazepam incorporating the science of Intravail. Intravail transmucosal absorption enhancement technology enables the noninvasive delivery of a broad range of protein, peptide, and small-molecule drugs. In its approval of VALTOCO, the FDA also granted Neurelis Orphan Drug Exclusivity and recognized VALTOCO's intranasal route of administration as a clinically superior contribution to patient care over the previously approved standard-of-care treatment (a rectal gel formulation of diazepam). In a long-term, open-label, repeat-dose clinical trial, the safety of VALTOCO was evaluated and more than 4,000 seizures were treated. The clinical trial included adult and pediatric patients aged 6 and older. VALTOCO was generally safe and well tolerated during clinical studies. The most common adverse reactions for diazepam (at least 4%) were somnolence, headache, and nasal discomfort.For more information on VALTOCO, please visit http://www.valtoco.com.

About Neurelis

Neurelis, Inc., is an innovation-driven neuroscience company providing a highly differentiated approach to target unmet medical needs. Neurelis is focused on the development and commercialization of product candidates for epilepsy and the broader central nervous system (CNS) market. On January 10, 2020, the U.S. Food and Drug Administration (FDA) approved Neurelis' VALTOCO(diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from an individual's usual seizure pattern in adult and pediatric patients 6 years of age and older. In addition to VALTOCO, the company is developing NRL-2 for intermittent use to control acute panic attacks, NRL-3 as a noninvasive acute therapy to stop seizures that have progressed to status epilepticus, and NRL-4 as a noninvasive rescue therapy to address the escalation of psychomotor agitation (PMA) symptoms outside of the medical setting. The Neurelis technology platform includes Intravail, ProTek and Hydrogel, three proprietary, noninvasive drug-delivery and stabilization technologies applicable to a wide range of molecules, including therapeutic proteins, peptides, non-peptide macromolecules, and small molecules. For more information on Neurelis, please visit http://www.neurelis.com.

Important Safety Information about VALTOCO:

Indication

VALTOCO (diazepam nasal spray)is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 6 years of age and older.

IMPORTANT SAFETY INFORMATION

RISK FROM CONCOMITANT USE WITH OPIOIDS

Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.

Contraindications: VALTOCO is contraindicated in patients with:

Central Nervous System (CNS) Depression

Benzodiazepines, including VALTOCO, may produce CNS depression. Caution patients against engaging in hazardous activities requiring mental alertness, such as operating machinery, driving a motor vehicle, or riding a bicycle, until the effects of the drug, such as drowsiness, have subsided, and as their medical condition permits.

The potential for a synergistic CNS-depressant effect when VALTOCO is used with alcohol or other CNS depressants must be considered, and appropriate recommendations made to the patient and/or care partner.

Suicidal Behavior and Ideation

Antiepileptic drugs (AEDs), including VALTOCO, increase the risk of suicidal ideation and behavior. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or unusual changes in mood or behavior. Advise patients and caregivers to be alert for these behavioral changes and to immediately report them to a healthcare provider.

Glaucoma

Benzodiazepines, including VALTOCO, can increase intraocular pressure in patients with glaucoma. VALTOCO may only be used in patients with open-angle glaucoma only if they are receiving appropriate therapy. VALTOCO is contraindicated in patients with narrow-angle glaucoma.

Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preservative

VALTOCO is not approved for use in neonates or infants. Serious and fatal adverse reactions, including "gasping syndrome," can occur in neonates and low-birth-weight infants treated with benzyl alcohol-preserved drugs, including VALTOCO. The "gasping syndrome" is characterized by central nervous system depression, metabolic acidosis, and gasping respirations. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known.

Adverse Reactions

The most common adverse reactions (at least 4%) were somnolence, headache, and nasal discomfort.

Diazepam, the active ingredient in VALTOCO, is a Schedule IV controlled substance.

To report SUSPECTED ADVERSE REACTIONS, contact Neurelis, Inc. at 1-866-696-3873 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Please read full Prescribing Information, including Boxed Warning, for additional important safety information.

For More Information:Mark Leonard[emailprotected]858-251-2100

SOURCE Neurelis, Inc.

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Neurelis Announces Four Poster Presentations For The Joint Meeting Of The International Child Neurology Association And Child Neurology Society -...