Puma Biotechnology to Present at the Credit Suisse 29th Annual Virtual Healthcare Conference – Yahoo Finance

TipRanks

Americans went to the polls today under the shadow of a resurging pandemic, with a substantial increase in cases nationwide and the number of people hospitalized with COVID-19 reaching record highs in a growing number of states. Meanwhile, it's still unclear what a second stimulus package from the federal government may look like and how long it will be until that arrives.To add fuel to this, there are several European governments that are starting to lock down their respective countries all over again in order to prevent the further spread of COVID.With all of this uncertainty, what is an investor to do? Adding dividend stocks as a potential defensive play can add protection to your portfolio.Weve opened up theTipRanks database, finding three stocks whose profile justifies the entry risk in todays conditions. All three offer at least 5% dividend yield, and backed by several analysts, enough to earn a strong buy consensus rating. Let's take a closer loo. AbbVie (ABBV)AbbVie is a pharmaceutical company, one of Big Pharmas major names. Pharmaceutical and biotech companies are known for their combination of high risk and high reward potential. The rewards and risks are both typified in Humira, the companys successful immunosuppressive anti-inflammatory drug. Humira is expected to bring in ~40% of AbbVies 2020 drug division revenues but with an expired patent, competition is growing. Against this backdrop, AbbVie had acquired another pharmaceutical company, Allergan, that increased top-line revenues by $16B for AbbVie while the combined companies bring in $2B in synergies. The acquisition showed investors that AbbVie is simultaneously looking beyond their holdings in Humira.Future guidance has revenues moving higher along with earnings. Guidance on revenues has been increased to $10.47 - $10.49 EPS versus $10.35 - $10.45 EPS. The earnings were enough to allow management to raise the dividend from $1.18 to $1.30. At $5.20 annualized, this dividend yields 6.11%, more than 2.5x the average dividend found among S&P listed companies. The payout ratio of 49.7% indicates that the dividend is safe current earnings easily cover it, and there is plenty of room for further growth.Covering the stock for SVB Leerink, analyst Geoff Porges noted, "AbbVie had another strong beat and raise in Q3, demonstrating their very resilient business during the pandemic and highlighting strong growth prospects for their core business. Guidance was once again raised, and the companys comments about mid- to long-term revenue potential for their core products were very positive [...] AbbVies valuation seems very attractive at todays price, and we see substantial upside potential as we expect the stock to revert to its more normalized absolute and relative multiple after the current election blues are resolved in the new year."To this end, Porges rates AbbVie an Outperform (i.e. Buy) along with a $119 price target. This figure suggests a potential upside of 35% over the next year. (To watch Porges track record, click here)Overall, Wall Street is very bullish on Abbvie. There are a total of 8 ratings; 7 Buys and 1 Hold -- all add up to a Strong Buy consensus rating. The stocks current price is $88 and the average price target is $110.13 suggesting 25% one-year upside move. (See ABBV stock analysis on TipRanks)WesBanco (WSBC)Next up is WesBanco, a bank operating in the region of western Pennsylvania, West Virginia, Ohio and Kentucky with 236 branches. The pandemic has struck financial institutions because of loans in default. Loan losses, or their potential, have forced banks and lenders to start building up reserve ratios and set aside revenue for loan losses.WesBanco has spent the past two quarters building up their reserve ratio with a large amount being set aside in Q2 and a smaller amount in Q3 and currently has an above-peer ratio level.Turning to the dividend, WSBC currently pays out 32 cents per common share, and even in the coronavirus crisis it held that payment steady. The 52-cent payment annualizes to $1.32 per share, and gives a considerable yield of 5.16%.Raymond James analyst William Wallace is standing squarely with the bulls, noting: "PTPP earnings came in above expectations as noted, driven largely by lower operating expenses and higher fee income. Ultimately, we expect investors to remain honed in on credit in the nearer-term, where the company's bolstered reserve continues to provide us with a certain degree of comfort. All in, with shares trading essentially in line with peers, we continue to view the risk/reward dynamic positively given the company's solid capital levels (+9% TCE), along with both promising core earnings and deferral trends."Unsurprisingly, Wallace rates WesBanco an Outperform (i.e. Buy) along with a $29 price target. This target suggests a potential upside of 15% over the next year. (To watch Wallaces track record, click here)Wallace is not the only fan of WSBC on Wall Street, as TipRanks analytics exhibit the stock as a Strong Buy. Based on 4 analysts tracked in the last 3 months, 3 rate the stock a Buy, while one says Hold. The 12-month average price target stands at $26.88, marking a 6.5% upside from where the stock is currently trading. (See WSBC stock analysis on TipRanks)CatchMark Timber (CTT)CatchMark Timber is an owner and operator of timberlands located in various parts of the country. The pandemic has not directly affected the timber industry. However, timber itself has maintained higher prices as home builders in the United States have seen increased demand. A lot of this new demand is generated from individuals moving out of cities into suburban areas.In the most recent quarter, Q3 2020 EBITDA for CatchMark Timber was above expectations coming in at $12.4MM versus $11MM consensus. The above-expectation earnings were attributed to cost controls from logging and hauling as well as SG&A costs. At the same time that CatchMark reported Q1 earnings, it also declared the Q3 dividend. The payment remains steady at 13.5 cents per share, yielding a solid 6%. The company has a 6-year history of keeping up its dividend payments, in all economic conditions.Adding to the good news, RBC Capital analyst Paul Quinn, rated 5-stars with TipRanks, has upgraded CTT to Outperform (i.e. Buy), while keeping his price target at $10. (To watch analyst track record, click here)As Quinn states, CatchMark reported Q3 results that were in line with our forecasts but above consensus expectations. Although there have been minimal changes in business prospects over the last few months, CatchMark shares have moved in a wide range around our target price of $10. With the share price having pulled back to an attractive level and future prospects remaining solid, we are increasing our rating."Overall, CTTs Strong Buy analyst consensus is derived from 3 "buy" and 1 "hold" ratings. Shares are priced at $8.91, and the average price target of $10.88 indicates potential for 22% growth. (See CTT stock analysis on TipRanks)To find good ideas for dividend stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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Puma Biotechnology to Present at the Credit Suisse 29th Annual Virtual Healthcare Conference - Yahoo Finance

Global Biotechnology/ Pharmaceutical Services Outsourcing Market 2020: Classification, Application And Specifications, Industry Overview, Analysis Of…

The report on global Biotechnology/ Pharmaceutical Services Outsourcing market is positioned to harness a clear perspective highlighting both value based and volume based market size estimations to encourage profit driven business decisions in the forecast tenure, 2020-25.

The report follows a systematic top-down analytical review to highlight note-worthy developments and lucrative business tactics that set the growth track effectively, complying with future ready business returns.

Access the PDF sample of Biotechnology/ Pharmaceutical Services Outsourcing market report @ https://www.orbisresearch.com/contacts/request-sample/2480889?utm_source=Atish

Incessant research efforts towards catering to divulge Biotechnology/ Pharmaceutical Services Outsourcing market relevant information have been employed gauging optimally into various ongoing market developments that have reflected and impacted market progression in multiple ways.

The key players covered in this studyQuantic GroupQuintilesIMSParexel International CorporationLachman AssociatesGMP PharmaceuticalsManagement ForumQuality ContextInspired PharmaConcept Heidelberg GmbHRSSL

Based on thorough research in the lines of primary and secondary research practices, global Biotechnology/ Pharmaceutical Services Outsourcing market is likely to witness extensive growth in foreseeable times. The report makes relevant efforts in drawing necessary attention towards unravelling significant data pertaining to both current and past developments.

Market segment by Type, the product can be split intoConsultingAuditing & AssessmentRegulatory AffairsProduct MaintenanceProduct Design & DevelopmentProduct Testing & ValidationTraining & EducationOthers

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[Application]

The report assessing Biotechnology/ Pharmaceutical Services Outsourcing market is poised to present accurate market relevant information across vertices such as M&A investments, business objectives set by frontline players as well as other contributing players and their elaborate references of business and commercial agreements, potential investment chains and a brief of their market positioning, besides profit and revenue cycles that remain highly relevant growth determinants.

Browse the complete Biotechnology/ Pharmaceutical Services Outsourcing market report @ https://www.orbisresearch.com/reports/index/global-biotechnology-pharmaceutical-services-outsourcing-market-size-status-and-forecast-2019-2025?utm_source=Atish

Additionally, this intense research report synopsis highlighting key developments have been referenced from the multi-stage developments across regions and countries. The report defining Biotechnology/ Pharmaceutical Services Outsourcing market specifically refers to elaborate developments across North and South America, besides harnessing discernable information on Europe. MEA, and APAC specific terrains.

About Us:Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customized reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

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Agricultural Biotechnology Market Size | Incredible Possibilities and Growth Analysis and Forecast To 2027 – Eurowire

The Global Agricultural Biotechnology Market report, published by Verified Market Research, is an extensive compilation of the essential aspects of the global Agricultural Biotechnology market, assessed thoroughly by our team of researchers. The market intelligence report offers insightful data and information relevant to the market to acquaint the readers with the lucrative growth prospects existing in this industry, eventually helping them formulate effective business strategies. The global Agricultural Biotechnology market report has been methodically curated using industry-verified data to offer information concerned with the leading manufacturers and suppliers engaged in this sector. It further focuses on their pricing analysis, gross revenue, product portfolio, sales network & distribution channels, profit margins, and financial standing.

Agricultural Biotechnology Market was valued at USD 35.6 Billion in 2018 and is projected to reach USD 74.92 Billion by 2026, growing at a CAGR of 9.70% from 2019 to 2026.

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Competitive Landscape:

The global Agricultural Biotechnology market is highly consolidated due to the presence of a large number of companies across this industry. The report discusses the current market standing of these companies, their past performances, demand and supply graphs, production and consumption patterns, sales network, distribution channels, and growth opportunities in the market. Moreover, it highlights the strategic approaches of the key players towards expanding their product offerings and reinforcing their market presence.

The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

The report further sheds light on the various strategic business initiatives undertaken by the key market contenders to fortify their foothold in this business sector. These strategies majorly include mergers & acquisitions, partnerships & collaborations, joint ventures, government and corporate deals, brand promotions, new product launches, and numerous others. In the later part of the report, the major components of the Agricultural Biotechnology industry, such as product type, application gamut, end-use industries, and the solutions and services offered by the leading manufacturers, have been analyzed. Numerical data and subjective information pertaining to each market segment have been featured in the report for better understanding.

Therefore, the latest research document includes competitive analysis, key market players, crucial industry-related facts & figures, sales revenue, product prices, gross margins, market shares, business strategies, dominant regions, and key developments.

Agricultural Biotechnology Market, By Organism Type

Plants Animal Microbes

Agricultural Biotechnology Market, By Application

Vaccine Development Transgenic Crops & Animals Antibiotic Development Nutritional Supplements Flower Culturing Biofuels

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The report encompasses the significant effects of the coronavirus pandemic on the Agricultural Biotechnology market and its key segments. The report offers a vivid picture of the current market scenario, closely investigating the impact of the pandemic on this specific business sphere, its leading players, supply chains, distribution channels, and its global scenario. The pandemic has affected the global industry extensively, subsequently disrupting the Agricultural Biotechnology market mechanism. Furthermore, the research study examines the Agricultural Biotechnology market and the recent disruptive changes in the business setting that followed the outbreak. Also, the future effects of the pandemic on the market have been assessed in the report.

Key Geographies Encompassed in the Report:

North America (U.S., Canada)Europe (U.K., Germany, Italy, France, Rest of EU)Asia Pacific (India, Japan, China, Australia, Rest of APAC)Latin America (Brazil, Argentina, Rest of Latin America)Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of MEA)

Market Taxonomy:

Chapter 1: Methodology & Scope

Definition and forecast parametersMethodology and forecast parametersData Sources

Chapter 2: Executive Summary

Business trendsRegional trendsProduct trends

Chapter 3: Industry Insights

Industry segmentationIndustry landscapeVendor matrixTechnological and innovation landscape

Chapter 4: Regional Landscape

Chapter 5: Competitive Outlook

Company ProfileBusiness OverviewFinancial DataProduct LandscapeStrategic Outlook

To read more about the report, visit @ https://www.verifiedmarketresearch.com/product/agricultural-biotechnology-market/

Advantages of the Agricultural Biotechnology Market Report:

The report offers a clear description of the global Agricultural Biotechnology market, containing the current market growth inclinations and future estimations to help businesses identify the potential investment areas.

The report covers the major market growth drivers, and constraints, alongside an extensive COVID-19 impact analysis.

The all-inclusive market feasibility reveals the profit-making trends to obtain a powerful foothold in the Agricultural Biotechnology industry.

The SWOT analysis and Porters Five Forces Analysis explicate the effectiveness of the customers and providers from a global perspective.

About us:

Verified Market Research is a leading Global Research and Consulting firm servicing over 5000+ customers. Verified Market Research provides advanced analytical research solutions while offering information enriched research studies. We offer insight into strategic and growth analyses, Data necessary to achieve corporate goals, and critical revenue decisions.

Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance use industrial techniques to collect and analyze data on more than 15,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

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Global Pharmaceutical & Biotechnology Environmental Monitoring Market 2020 by Company, Regions, Type and Application, Forecast to 2026 – Aerospace…

MarketsandResearch.biz has published the latest and most trending report entitled Global Pharmaceutical & Biotechnology Environmental Monitoring Market 2020 by Company, Regions, Type and Application, Forecast to 2026 that collates in-depth study and assessment of the market. The report frames an in-depth evaluation of this industry space, analyzed it in terms of numerous parameters. The report underlines crucial elements about the market taking into consideration the current scenario and the industry size as well as forecast scenario (2020-2025) dependent on the revenue and volume parameters. This report is dedicated to rewarding the requirements of the clients by giving them thorough insights into the global Pharmaceutical & Biotechnology Environmental Monitoring market. It also gives a point by point breakdown dependent on the in-depth research of the market elements like market size, opportunities, and operation landscape and trend analysis. It also highlights the overall market presence in terms of segmentation based on different aspects.

Key Player Classification:

The report has recognized major key players as top brands across different regions. These key players are manufacturing the products to meet the demand request of the consumers. The global Pharmaceutical & Biotechnology Environmental Monitoring market has immense demand that the supply falls short at times. These key players give in collective efforts to ensure that the market reaches to a strong position. The report assesses each and every player on the basis of the main business, gross margin, revenue, sales, price, competitors, manufacturing base, product specification, product application, and product category.

The global Pharmaceutical & Biotechnology Environmental Monitoring market is highly competitive and consists of a number of major manufacturers like: Danaher Corporation, Thermo Fisher Scientific, Merck KGaA, Eurofins Sinensis, Lonza, Biomerieux, VAI, Cosasco, RMONI, Amphenol Advanced Sensors, Vaisala,

NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

DOWNLOAD FREE SAMPLE REPORT: https://www.marketsandresearch.biz/sample-request/46003

Market Size Estimation:

Experts have used top-down and bottom-up approaches to validate the global product market size market and estimate the market size for company, region segments, product segments, and application (end users). The global Pharmaceutical & Biotechnology Environmental Monitoring market estimations in this report are based on the marketed sale price of the product. The percentage splits, market share, and breakdown of the product segments are derived. The regional splits of the overall product market and its sub-segments are based on the percentage adoption or utilization of the given product in the respective region or country.

The product types covered in the report include: Monitoring Equipment, Media, Software, Microbiology Services

The application types covered in the report include: Pharmaceutical Industry, Biotechnology Industry, Academic & Research Institutes,

On the basis of geographical boundaries, the market is classified into: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Alnylam Wins Prestigious Prix Galien Award for Best Biotechnology Product with First-Ever Approved RNAi Therapeutic, ONPATTRO (patisiran) – Business…

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today announced it has won the 2020 Prix Galien USA Award for Best Biotechnology Product for ONPATTRO (patisiran). The award, which recognizes excellence in scientific innovation that improves the state of human health, was presented by the Galien Foundation during the 50th Annual Prix Galien USA Awards ceremony yesterday.

We are thrilled to receive this prestigious recognition for ONPATTRO and want to share this award with the incredible patients, caregivers, scientists, healthcare professionals, and colleagues that helped us succeed in making RNAi therapeutics, an entirely new class of medicines, a reality for patients, said John Maraganore, Ph.D., Chief Executive Officer of Alnylam. The breakthrough approval of ONPATTRO was a result of nearly two decades of determination to deliver the first-ever FDA-approved treatment to adult patients living with the polyneuropathy of hereditary ATTR (hATTR) amyloidosis. We also want to recognize the continued industry efforts in helping those living with this progressive, debilitating condition.

In 2019, ONPATTRO won the Prix Galien Award for Best Biotechnology Product in Italy and the Netherlands.

About ONPATTRO (patisiran)

ONPATTRO is an RNAi therapeutic that was approved in the United States and Canada for the treatment of the polyneuropathy of hATTR amyloidosis in adults. ONPATTRO is also approved in the European Union, Switzerland and Brazil for the treatment of hATTR amyloidosis in adults with Stage 1 or Stage 2 polyneuropathy, and in Japan for the treatment of hATTR amyloidosis with polyneuropathy. ONPATTRO is an intravenously administered RNAi therapeutic targeting transthyretin (TTR). It is designed to target and silence TTR messenger RNA, thereby blocking the production of TTR protein before it is made. ONPATTRO blocks the production of TTR in the liver, reducing its accumulation in the bodys tissues in order to halt or slow down the progression of the polyneuropathy associated with the disease. For more information about ONPATTRO, visit ONPATTRO.com.

ONPATTRO (patisiran) lipid complex injection Important Safety Information

Infusion-Related Reactions

Infusion-related reactions (IRRs) have been observed in patients treated with ONPATTRO. In a controlled clinical study, 19 percent of ONPATTRO-treated patients experienced IRRs, compared to 9 percent of placebo-treated patients. The most common symptoms of IRRs with ONPATTRO were flushing, back pain, nausea, abdominal pain, dyspnea, and headache.

To reduce the risk of IRRs, patients should receive premedication with a corticosteroid, acetaminophen, and antihistamines (H1 and H2 blockers) at least 60 minutes prior to ONPATTRO infusion. Monitor patients during the infusion for signs and symptoms of IRRs. If an IRR occurs, consider slowing or interrupting the infusion and instituting medical management as clinically indicated. If the infusion is interrupted, consider resuming at a slower infusion rate only if symptoms have resolved. In the case of a serious or life-threatening IRR, the infusion should be discontinued and not resumed.

Reduced Serum Vitamin A Levels and Recommended Supplementation

ONPATTRO treatment leads to a decrease in serum vitamin A levels. Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking ONPATTRO. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with ONPATTRO, as serum levels do not reflect the total vitamin A in the body.

Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g. night blindness).

Adverse Reactions

The most common adverse reactions that occurred in patients treated with ONPATTRO were upper respiratory-tract infections (29 percent) and infusion-related reactions (19 percent).

For additional information about ONPATTRO, please see the full Prescribing Information.

About hATTR Amyloidosis

Hereditary transthyretin (TTR)-mediated amyloidosis (hATTR) is an inherited, progressively debilitating, and often fatal disease caused by mutations in the TTR gene. TTR protein is primarily produced in the liver and is normally a carrier of vitamin A. Mutations in the TTR gene cause abnormal amyloid proteins to accumulate and damage body organs and tissue, such as the peripheral nerves and heart, resulting in intractable peripheral sensory-motor neuropathy, autonomic neuropathy, and/or cardiomyopathy, as well as other disease manifestations. hATTR amyloidosis, represents a major unmet medical need with significant morbidity and mortality affecting approximately 50,000 people worldwide. The median survival is 4.7 years following diagnosis, with a reduced survival (3.4 years) for patients presenting with cardiomyopathy.

About RNAi

RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as a major scientific breakthrough that happens once every decade or so, and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines, known as RNAi therapeutics, is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of todays medicines by potently silencing messenger RNA (mRNA) the genetic precursors that encode for disease-causing or disease pathway proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.

About Alnylam Pharmaceuticals

Alnylam (Nasdaq: ALNY) is leading the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system (CNS)/ocular diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach for the treatment of a wide range of severe and debilitating diseases. Founded in 2002, Alnylam is delivering on a bold vision to turn scientific possibility into reality, with a robust RNAi therapeutics platform. Alnylams commercial RNAi therapeutic products are ONPATTRO (patisiran), approved in the U.S., EU, Canada, Japan, Brazil, and Switzerland, and GIVLAARI (givosiran), approved in the U.S, EU, Brazil and Canada. Alnylam has a deep pipeline of investigational medicines, including six product candidates that are in late-stage development. Alnylam is executing on its Alnylam 2020 strategy of building a multi-product, commercial-stage biopharmaceutical company with a sustainable pipeline of RNAi-based medicines to address the needs of patients who have limited or inadequate treatment options. Alnylam is headquartered in Cambridge, MA. For more information about our people, science and pipeline, please visit http://www.alnylam.com and engage with us on Twitter at @Alnylam or on LinkedIn.

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Alnylam Wins Prestigious Prix Galien Award for Best Biotechnology Product with First-Ever Approved RNAi Therapeutic, ONPATTRO (patisiran) - Business...

Biotechnology Market 2020: Global Industry Size, Share, Future Challenges, Revenue, Demand, Industry Growth and Top Players Analysis to 2027 – The…

Beathan Report published a new report, titled, Biotechnology Market. The report offers an extensive analysis of key growth strategies, drivers, opportunities, key segment, Porters Five Forces analysis, and competitive landscape. This study is a helpful source of information for market players, investors, VPs, stakeholders, and new entrants to gain thorough understanding of the industry and determine steps to be taken to gain competitive advantage.

The report offers key drivers that propel the growth in the global Biotechnology market. These insights help market players in devising strategies to gain market presence. The research also outlined restraints of the market. Insights on opportunities are mentioned to assist market players in taking further steps by determining potential in untapped regions.

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The research offers a detailed segmentation of the global Biotechnology market. Key segments analyzed in the research include type, drive system, application and geography. Extensive analysis of sales, revenue, growth rate, and market share of each type, drive system, application, and geography for the historic period and the forecast period is offered with the help of tables.

The market is analyzed based on regions and competitive landscape in each region is mentioned. Regions discussed in the study include North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa). These insights help to devise strategies and create new opportunities to achieve exceptional results.

The following players are covered in this report:

Johnson & Johnson Services, Inc.

F. Hoffmann-La Roche Ltd

Pfizer

Merck &

Sanofi

AstraZeneca

Gilead

CELGENE CORPORATION

Biogen

Amgen, Inc

Abbott

Novo Nordisk A/S

Novartis AG

Lonza

Biotechnology

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Key Benefits:

The market player positioning segment provides an understanding of the current position of the market players active in the Biotechnology industry.

Breakdown Data by Type

DNA Sequencing

Nanobiotechnology

Tissue engineering and Regeneration

Fermentation

Cell Based Assay

PCR Technology

Chromatography Market

Others

Biotechnology Breakdown Data by Application

Health

Food & Agriculture

Natural Resources & Environment

Industrial Processing

Bioinformatics

Others

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Key offerings of the report:

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For I+I’s Selam Kelati, Natural Remedies Are an Ages-Old Family Tradition – CBD Today

After a 20-year career in the corporate world, Selam Kelati was ready for a change. Born and raised in Ethiopia, she grew up in a culture where plants and herbs were part of everyday life and utilized in an array of food, medicines, and cosmetics. So, when she decided to build a business of her own, she constructed the frame around her knowledge of natural remedies and homeopathic plants.

Launching a startup in the competitive U.S. cosmetics-and-skincare sector was no small endeavor. The industry is dominated by powerful multinational brands. But with estimated revenues of $645 million in 2019, the CBD segment of the market still offers plenty of room for startups. Kelati, along with business partner Jennifer Culpepper, seized the opportunity and created I+I Botanicals. (The name is pronounced I and I.)

The company takes an eco-conscious, holistic approach that upholds the traditions and ethics Kelati learned at an early age. Our core message is good for the earth, good for the soul and, of course, good for the body, she said. I and I comes from the Rastafarians, who use the words to mean you and I are the same. The message is that the love you give to yourself, try to give it to another.

Kelati and her eight siblings were raised by Eritrean parents and an extended family that passed down recipes for plant-based foods and medicine. Her grandmother was known in her village as an herbal medicine expert who had a deep knowledge of plants in the region and used them to create concoctions for health, beauty, and wellness.

People would come from near and far to get some kind of something that she would mix for medical purposes, so this was in our house and our family, Kelati explained. Anything to do with herbs or medicine or cooking was just a natural thing in our household. You sit with your grandmother and your aunties and your mom and you learn, but you dont even understand you are learning at that age, because its part of your life, right? So thats where my passion for natural ingredients comes from, and its something Ive carried with me throughout my life.

The prickly pear cactus grows abundantly in Eritrea and is utilized in a number of different ways, from making jams to feeding livestock. Pressing the seeds creates an oil that is beneficial for skin and hair, Kelati said, and it also has anti-aging and anti-inflammatory properties. Another ingredient widely used in her native region is moringa oil. The substance is created by processing the seeds and leaves of the moringa tree, which has been dubbed the miracle tree due to its bountiful medicinal and nutritional attributes.

Moringa oil mimics the natural oil we create in our body, so it does help with your hair shine and keeping it healthy and not breaking, Kelati said. And for the skin as well. Its nutrient-dense, which helps reduce the appearance of wrinkles.

There are a lot of people who dont understand that its not just about working hard. Its also about having a starting point.

Kelati has been experimenting with her own natural plant remedies for most of her life and enjoys sharing her creations with friends and family to gather feedback about what works and what does not. Soon after she heard about CBDs anti-inflammatory, antioxidant, and skin-soothing properties, she immersed herself in research. She went to trade shows and networked with operators in the industry. During her investigation, one product, in particular, stood out to her. It was an under-eye cream that [my business partner] Jennifer shared with me, and I remember seeing the puffiness under my eye being reduced within three or four days of using it, she said. That made me a believer.

I told Jennifer I wanted to have my own beauty line based on natural ingredients, because this is what I know and have been taught since childhood, she continued. Theres some kind of magic we can create using CBD. So, Jennifer and I brainstormed and I+I was born in the process.

As working mothers, Kelati and Culpepper understand the unique pressures women face on a daily basis, juggling roles from caregiver to breadwinner and trying to squeeze in time for themselves when and where they can. As such, one of their goals is to give women an easy way to incorporate CBD products into their daily routines and enjoy a relaxing moment or two amid the hustle and bustle.

The global CBD skincare market is expected to reach $1.7 billion by 2025, according to a report by Grand View Research Inc. North America, which accounted for more than 40 percent of the market in 2018, will lead the way, Grand View projected. For brands like I+I, which has a relatively small footprint at this point, establishing a presence in the lucrative space early is crucial. The effort starts with creating unique, compelling products that will stand out from the crowd.

The process Kelati uses to formulate new products is a combination of her homespun plant knowledge and ad hoc testing, with some modern science and technology to clinch the deal. [Jennifer and I] experiment with [a new formulation] ourselves to see how it feels, to get the texture and viscosity we want and the result we want to get, she said. Then we have chemists that we work with, and they produce the product at their facilities.

I+Is original CBD products include moisturizing Dry Oil Body Mist (jojoba oil, moringa oil, and a blend of citrus essential oils), hydrating Face Serum (prickly pear seed oil and hyaluronic acid), and relaxing Bath Tea Blend (essential oils). One of the most popular products, Kelati said, is Coffee Body Scrub, a foaming exfoliator that contains a combination of seven plant extracts, CBD, and fair-trade Ethiopian coffee. This is something we actually use back home after we finish drinking coffee, Kelati said. Using the leftovers, you can scrub it around your feet to make them smooth.

Other ingredients in traditional Ethiopian and Eritrean health and beauty regimens happen to be on-trend in Western markets right now. Called adaptogens, the materials comprise nontoxic plants and plant derivatives that are believed to help the body resist stress. Scientific research and validation for adaptogens is scarce, but adaptogenic concoctions have been used for centuries in Chinese, African, and other cultures. I realized when I looked at the list of ingredients that I knew growing up, they are actually considered adaptogens, although we didnt call them that, Kelati said. So we decided it makes sense to follow up and create products using those ingredients.

The importance of sourcing products from sustainable, eco-conscious farmers and manufacturers cannot be overstated, she said. All the CBD and most other essential ingredients in I+I products are sourced in the U.S., but Kelati also maintains several key partnerships back home. The main ingredients that represent the product are coming from somewhere we actually source ourselves, she revealed.

I+I primarily operates in the beauty segment, but Kelati wants to grow the business into other verticals and develop products that appeal to a wider audience. One thing we are working on is beard oil so we can give something to the guys, she said.

As legalization has swept across the U.S., social equity has become one of the hottest of the hot-button issues in the cannabis and hemp industries. People of color and their advocates are fighting for a bigger stake in a space that is overwhelmingly controlled by White investors and operators. Despite legislation and other efforts designed to promote ownership and participation by Black, Indigenous, and people of color (BIPOC) stakeholders, very little progress has been made thus far.

As a Black female entrepreneur, Kelati understands the challenges. She is all too familiar with the discrimination and other issues people of color face as they try to build brands from the ground up with scarce access to investment or business loans. But none of this has tempered her enthusiasm, and Kelati is eager to build I+Is momentum across the country in 2021, one mist and scrub at a time.

Being a Black woman, I did recognize at an early stage that were going to have a lot of challenges, Kelati said. People are going to have doubts about everything we say. But I do see theres a lack of mentorship and representation, and when we go to trade shows, we dont see a lot of buyers who are minorities. So, its justI have to prepare myself more than my colleagues or my competition [must], because I just want to make sure I am representing myself fully so I can capture the audience.

On a more optimistic note, she said Black women are one of the fastest growing groups in business, and in the beauty industry she believes the situation is becoming more favorable for BIPOC and women. She cited the 15-percent pledge as one example of the changing tides. In June, Sephoraa French multinational chain of personal care and beauty storesannounced its U.S. unit would pledge to grow the share of Black businesses it helps empower to at least 15 percent. The company created an advisory group that includes brands owned by people of color to help make changes. Sephora currently works with about 300 brands in the U.S., where it has more than 400 retail storefronts plus kiosks in J.C. Penney stores.

One of the most critical factors for young businesses is raising capital, and Kelati said that has been a difficult hurdle to surmount. When it comes to attracting investors, or even getting grants or any kind of loan, its not that easy for women of color, she said. Weve been trying to get investors to be attracted to our message and product, but it has been very, very challenging. Definitely, if there is more mentorship and representation, those can make a big difference.

Kelati also noted most Black business owners are new to the business world and dont have the same level of experience, capital, or the connections enjoyed by many White business owners. Everybody does not start from the same beginning, and Black business owners dont have that foundation. We start everything from scratch, she said. So, to expect to go the same speed as the competition who actually have a good jumpstart, its really not fair. When you go networking, you dont see someone who looks like you or someone who understands your struggle. There are a lot of people who dont understand that its not just about working hard. Its also about having a starting point. The experience is not the same.

Kelati has seen some signs over the past year that give her hope for a brighter future for BIPOC-owned businesses. In the meantime, I+I is doing its part to highlight a proud legacy with roots in East Africa being carried forward by modern-day female entrepreneurs.

To be honest, it makes me comfortable now to say that, yes we have a Black woman business owner, and we always promote ourselves as a woman-owned business and my face is out there, she said, explaining that even in the cosmetics industry, women-owned businesses face a steep climb. It just makes us more comfortable now because we feel like the [equity] movement [in cannabis] is genuine, and people are trying to make a difference and inviting diversity into this industry.

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For I+I's Selam Kelati, Natural Remedies Are an Ages-Old Family Tradition - CBD Today

From COVID-19 To Cancer: James Drake Discusses the Potential Health Benefits of Resveratrol – EconoTimes

Resveratrol could be the key to numerous future medical treatments.

Resveratrol is a natural polyphenol that has been suggested to benefit a myriad of health conditions: indeed, a search on the worlds largest medical journal library delivers almost 40,000 results for resveratrol. The naturally occurring compound can be found in several foods, including berries, peanuts and wine, and although its widely claimed to benefit diseases from coronavirus to cancer, there is as-yet no hard evidence to prove the benefits of the supplement.

Given the lack of hard data around resveratrol and lack of regulation, many healthcare professionals are reluctant to officially recommend it to patients, yet it remains popular as a supplementary medicine, not least for its most recent fame as a potential anti-coronavirus agent. Science philanthropist James Drake is a life-long believer in the compounds health benefits, and believes it is a valuable natural supplement, both in the fight against disease and to maintain healthy aging.

The Health Benefits of Resveratrol

Resveratrol is thought to have many pharmaceutical properties, including antioxidant, anti-aging, anti-inflammatory, anti-cancer, neuro-protective and more. While there is scant conclusive data on the exact molecular mechanisms and benefits of resveratrol on human health, there are a multitude studies showing benefit to both animals and humans. Studies have postulated a range of mechanisms of action potentially responsible for the reported benefits of resveratrol, including:

The triggering of a range of antioxidant enzymes, ultimatively leading to reduced oxidative stress

Causing overexpression of the enzyme SIRT1, which is involved in the regulation of metabolism in multiple body tissues

Inhibition of enzymes associated with neurological disorders

As a result, resveratrol has been implicated in health conditions including:

Reducing the risk or level of:

Osteoarthritis

Neurodegenerative disease

Cancer

Malaria

Insulin resistance

Respiratory viral infections, including COVID-19

High blood pressure

Cardiovascular disease

Skin inflammation

Hepatitis

Urinary tract infections

Fungal diseases

Improving the condition of:

Inflammatory responses

Blood flow

Circulation

Skin and eye health

The immune system

Weight loss

Here, James Drake explores seven of the major diseases, infections, and conditions that resveratrol has been claimed to relieve or prevent and explores why the chemical compound has so much potential on the medical scene.

Some people who struggle with osteoarthritis value resveratrols anti-inflammatory properties and find that supplements can effectively reduce pain. Though the antioxidant doesnt repair damaged tissue, it is thought that it can help to prevent tissue erosion by inhibiting some cell signalling proteins that are involved in inflammation, therefore reducing articular cartilage breakdown. and serum biomarkers. One recent study found that resveratrol supplements, when taken in combination with meloxicam, can reduce pain and inflammation in patients suffering from knee osteoarthritis.

Several studies have demonstrated that resveratrols antioxidant properties reduce oxidative stress, thereby improving cognitive function, memory, and cerebral blood flow. Oxidative stress is a driver of various neurodegenerative diseases, such as Alzheimers, multiple sclerosis, and Parkinsons. James Drake, who funds a series of research studies into neurodegenerative decline, highlights that developing safe drugs to treat neurological disease is a major challenge for the medical sector, but that resveratrol could play a role in neuroprotection because of its antioxidant properties and low toxicity.

Research shows that resveratrol can have an anti-ageing effect on animals, though we dont yet know for sure whether the effects are the same for humans. To explore this, Alzheimers News Today details recent studies into resveratrols potential effects on dementias. Though there is no current conclusive evidence for resveratrols effectiveness in treating dementia, the chemical compound could become essential to future neurodegenerative treatments as research progresses.

Cancer

Resveratrol has long been highlighted for its anti-cancer properties, though there are still few evidence-based human studies to support this. Animal research suggests that the chemical compound may stop cancer cells from multiplying, enhance the effectiveness of chemotherapy, and reduce the side effects of radiation. Research suggests that resveratrol could also suppress cell proliferation in human tumour cells and have further therapeutic effects on cancer patients. In particular, a study from the MD Anderson Cancer Center concludes that resveratrol can break down cancer cells in various ways to treat cervical neoplasia.

Malaria

Various studies, including research from The National Institutes of Health, show that resveratrol can help to fight malaria. As a result, scientists are developing candidate vaccinations that they hope will combat the illness, which kills over one-million people around the world every year. The National Institutes of Health shows that resveratrol can significantly reduce malarias ability to adhere to blood vessels in cells. When combined with antimalarial chemotherapy, resveratrol could be key to treating the disease.

Diabetes and Metabolic Disorders

Both anecdotal and evidence-based studies have linked resveratrol with improving metabolic conditions and diabetes. For example, one such clinical trial published in 2016 investigated the effect of resveratrol on insulin resistance, glucose and lipid metabolism in non-alcoholic fatty liver disease. The study found that resveratrol supplementation may benefit patients with the disease, after seeing a marked decrease in cholesterol, glucose and other factors, and an improvement in inclusion resistance. Another study from 2017 examined the effect of resveratrol on artery stiffness in people with diabetes, finding that resveratrol supplementation correlated with a reduction in aortic stiffness in patients with particularly stiff aortas. This effect is attributed to the compounds role in activating the SIRT1 protein, and therefore slowing the effects of aging.

Respiratory Viral Infections

Many studies into the effectiveness of resveratrol focus on its antioxidant, anti-inflammatory, and anti-microbial benefits. However, a recent review from the Department of Public Health and Infectious Diseases at the University of Rome has highlighted resveratrols promising antiviral activity against viruses that cause respiratory infections. The study concludes that resveratrol could be key to preventing and treating respiratory syncytial virus, influenza virus, and SARS-CoV-2.

COVID-19

Amongst these respiratory viral infections, COVID-19 is the newest global threat. Over the last year, scientists and medical professionals have been grappling to develop effective coronavirus treatments. However, back in 2017, BioMed Central published a study that analysed resveratrols antiviral performance and its ability to protect against MERS-CoV, a viral pathogen that caused the MERS epidemic (and which is similar to the COVID-19-causing virus, SARS-CoV-2). The research team found that resveratrol significantly inhibits the virus and prolonged cellular survival, concluding that the natural polyphenol is a potent anti-MERS agent in vitro. Given the similarities between the viruses, its possible that resveratrol could offer some protection against SARS-CoV-2. Indeed, several research studies are already ongoing in this area.

Taking Resveratrol Supplements

The possible health benefits of resveratrol are seemingly endless, with new studies being published every week on its links with improving a multitude of conditions and diseases. However, it should be noted that resveratrol is as yet unregulated and is not prescribed by medical professional. A large amount of the existing information on resveratrol is based on animal or in vitro studies, rather than evidence-based human trials, so we do not yet know the exact benefits of the supplement, nor whether it causes any significant side effects in humans.

That being said, resveratrol is naturally abundant in food stuffs including berries, peanuts, grapes, and by extension red wine. However, the level of resveratrol in these foods is so low that we cannot absorb a therapeutic dose through dietary sources alone. James Drake has taken resveratrol supplements for many years without any known side effects. He highlights that the human body only absorbs around 10% of a supplement, which is why he takes 250 mg capsules. You can buy resveratrol from most reputable health food shops.

About James Drake

James Drake is a science-focused philanthropist who has founded multiple non-profit organisations, including The Drake Foundation and the Drake Calleja Trust. The Drake Foundation funds essential studies into the connection between repetitive head injuries obtained in sports and neurodegenerative decline. Its hoped that these studies will help to inform safe sporting protocols when it comes to head injuries and accelerate vital knowledge share in the medical space. Since its launch in 2014, The Drake Foundation has invested over 2 million into sports-related concussions research.

Meanwhile, Future Science Group (FSG) is a progressive scientific publisher, curating trusted online, print and in-person resources to serve the scientific and medical communities. Although FSGs foundation is in cutting-edge, peer-reviewed scientific journals, the Group has expanded over the years to publish digital/virtual hubs and run events, as well as creative services and publishing solutions.

When James isnt focusing his philanthropic ventures on scientific missions, his other passion lies in the arts. Among his philanthropic projects in music and art is the Drake Calleja Trust, which funds scholarships for talented young classical musicians as they aim to further their musical careers and studies.

Learn more about James Drake at http://www.jamesdrake.com. Alternatively, get in touch by emailing james@jamesdrake.com or connecting on Twitter at @jamesjpdrake.

This article does not necessarily reflect the opinions of the editors or management of EconoTimes

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From COVID-19 To Cancer: James Drake Discusses the Potential Health Benefits of Resveratrol - EconoTimes

The Specter of Endothelial Injury in COVID-19 – The Scientist

In early March, in a conference call with researchers in China, hematologist Alfred Lee, George Goshua, and others at the Yale School of Medicine were forewarned about an unusual finding in COVID-19 patients in advanced stages of the disease. Doctors were observing ischemic digits, or black fingers and toes. To Lee and Goshua, this sounded like a microvascular thrombosis, minute blood clots in small blood vessels. A few weeks later, the Yale physicians were confronted with their first COVID-19 death, ostensibly due to a major blood clot in the patients lung, which prompted them to set up a panel of clotting tests for COVID-19 patients.

What came back was something Lee had never seen before: levels of the von Willebrand factor (VWF), a protein involved in blood clotting, were through the roof; they had surpassed the upper limit of detection of the laboratory assay the group was using. Because VWF is released from endothelial cells that line blood vessels, Lees natural inference was that the endothelium was somehow damaged and releasing enormous amounts of VWF that was then contributing to blood clots.

The Yale team then ran a series of screens for other markers of endothelial damage on 68 COVID-19 patients, and the results published in The Lancet Haematology in June show that proteins such as soluble P-selectin were also elevated in critically ill COVID-19 patients compared with healthy controls. One of the markers, soluble thrombomodulin, even correlated with how long patients stayed in the hospital and whether they died. From these data, the investigators deduced that endothelial injury is linked to disease severity in COVID-19 and that strategies geared toward palliating this damage could improve disease outcomes.

Its impossible to say which came firstthe coronavirus infection or the endothelial damage, which is a known feature of diabetes, hypertension, and other diseases, notes Miriam Merad, an immunologist at the Icahn School of Medicine at Mount Sinai in New York who was not involved in the study. Conditions such as diabetes, hypertension, obesity, and agingcomorbidities present among Lees COVID-19 patientscould have also played a part in the vascular damage, she adds. Still, I think studying the vasculature is very important [in COVID-19], she tells The Scientist.

Goshua comments that to be able to see an endothelial cell signal despite having only one blood sample per patient was something quite profound. In fact, researchers have come to view the vasculature as the tissue most vulnerable to damage from SARS-CoV-2 infection, Thomas Lscher, a cardiologist at Imperial College London who has been studying the endothelium for more than three decades, tells The Scientist.The concept that the endothelium is the main target of this virus is really very important. Endothelial cells in the lungs play a central role in orchestrating damage to this organ, which is the chief target of the SARS-CoV-2.

The endothelium comprises a single layer of cells that forms the interior lining of blood vessels throughout the body. The tissue physically insulates blood elements from the highly thrombogenic, or clot-promoting, subendothelial connective tissue. In addition, under normal conditions, blood cells flow past without getting stuck because of the balance between the pro- and anti-clotting properties of the endothelium.

The endothelium is like Teflon. Nothing sticks to it, Harvard Medical Schools Denisa Wagner tells The Scientist. But just as a Teflon pan becomes sticky when scratched, a host of factorsincluding viral infection and encounters with agents of inflammationmakes it sticky. Such insults trigger endothelial release of VWF, which tethers plateletscells involved in clottingto the vessel wall, while the elevation of P-selectin causes leukocytes or immune cells to stick to the endothelium as well. This sets in motion a cascade of events that drives clot formation and inflammationtwo defining features of severe SARS-CoV-2 infection.

Pathology and autopsy studies have found particles of SARS-CoV-2 inside endothelial cells, and a growing body of evidence suggests that the endothelium plays a key role in the disease. In the early days of the pandemic, doctors discovered that damage to the endothelial lining in the lungs was associated with the fluid leakage and acute respiratory distress syndrome. Following this, researchers linked blood clots in the lungs and elsewhere to endothelial injury, and studies found viral particles in endothelial cells in organs other than the lungs, such as the kidneys. Thus, damage to the endothelium and the ensuing clotting and inflammation emerged as potential drivers of the strokes, cardiac injury, kidney disease, and other features of the disease.

Researchers have come to view the vasculature as the tissue most vulnerable to damage from SARS-CoV-2 infection.

The protean manifestations of COVID-19 strongly implicate activation and dysfunction of the endothelium as a unifying consequence of infection, which can help us frame our thinking about the disease [mechanism], says Peter Libby, a cardiovascular specialist at Harvard Medical School who has been studying the endothelium for nearly 40 years. He adds that this hypothesis helps [us] understand why this disease so perniciously affects so many different organ systems.

This hypothesis has been primarily based on clinical observations. Lees finding of high VWF levels and another study from Western Universitys Douglas Fraser offer the best mechanistic evidence. Fraser and his colleagues tracked endothelial markers in 10 ICU patients with COVID-19, 10 ICU patients who were hospitalized for other reasons, and 10 healthy controls. The team found results similar to Lees investigation, such as raised plasma VWF and soluble P-selectin levels. In addition, Fraser and his colleagues noted telltale signs of damage to the glycocalyx, a moss-like molecular coating that envelops the endothelium, in COVID-19 patients.

Aaron Petrey, an immunologist and glycobiologist at the University of Utah School of Medicine, says that glycocalyx degradation and shedding is a theme in sepsiswhich can occur in COVID-19so its unclear if this is a unique feature of COVID-19.

Wagner, who has studied the endothelium for close to 40 years, tells The Scientist that both studies are a very good beginning to studying the endothelium in COVID-19. She says the finding that VWF is majorly increased is particularly noteworthy. That, I think, is super important to the increased tendency for clotting seen in COVID-19 patients.

Fraser, who published the results in August, says keeping close watch on endothelial cell markers and glycocalyx degradation could aid doctors in treating COVID-19 patients, alerting them to when its time to deploy medical interventions such as ventilators. Libby adds that these endothelial indicators also give doctors tools to assess which patients are likely to develop a blood clot and therefore should be treated with appropriate medications, such as blood thinners.

A few other reports from France, Germany, and China that have looked at various markers of endothelial and glycocalyx damage, both in vitro and in vivo, link endothelial damage to the severity of disease. All these studies bear witness to the endothelial cell dysfunction of COVID-19.

Lscher, who was not involved in any of these studies, says these interrogations of the endothelium are stimulating, but they are not solving the problem yet. Whats the first step that initiates this cascade of events? Thats the real questionthat hasnt been solved yet.

A motley of studies are looking at ways to restore endothelial integrity in COVID-19 patients using various agents, including P-selectin blockers. Targeting the complement cascadean inflammatory pathway that causes endothelial dysfunctionis another approach in clinical testing, with one exploratory Phase 2 trial recently attesting to the safety and tolerability of anti-complement therapy and reporting early efficacy signals.

Breaking up strings of VWF is yet another tactic that might work, says Wagner. As endothelial cells release abundant amounts of VWF, the molecules can self-associate and clog small blood vessels, but an enzyme present in plasma called ADAMTS13 chops up clusters of VWF. In COVID-19, ADAMTS13 levels plummet and, along with extremely high VWF levels, portends severe disease. Its a recipe for trouble, says Wagner. I believe that supplying ADAMTS13 to COVID-19 patients with high VWF would significantly reduce thrombosis and organ damage. Currently, recombinant ADAMTS13 is being trialled in thrombotic thrombocytopenic purpura, a condition where ADAMTS13 deficiency leads to excess VWF and minute clots form in small blood vessels, but so far is not being tested in COVID-19 patients.

Christian Con Yost, a pediatrician at the University of Utah School of Medicine, tells The Scientist that breaking down these large VWF aggregates might also tame the downstream inflammation and accumulation of platelets and leukocytes. Lee agrees that the VWF/ADAMTS13 axis is worth further investigation. Were looking at this very closely, he says.

Targeting these pathways in isolation may ameliorate disease severity but is unlikely to completely attenuate disease progression.

Jamie OSullivan, Royal College of Surgeons in Ireland

Lscher, Libby, and other endothelial experts assert that targeting the two primary pathways to which the endothelium is intricately linkedhyperinflammation and clottingwould be the most beneficial. Reflecting on the current status of these two types of therapies, Libby says that the clinical research field is still in the era of non-randomized observational data and that outcomes of randomized placebo-controlled trials are desperately needed.

Its interesting to try this but Im not sure that [it] will be sufficient to change the course of the disease, Lscher says of these diverse approaches to address endothelial mayhem. This is not a very specific infection. There are many pathways. Thats the dilemma.

Jamie OSullivan, a vascular biologist at the Royal College of Surgeons in Ireland, explains to The Scientistin an email: Targeting these pathways in isolation may ameliorate disease severity but is unlikely to completely attenuate disease progression.

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The Specter of Endothelial Injury in COVID-19 - The Scientist

‘Baby Shark’ is now the most watched YouTube video of all time – Mashable

Where were you when you first heard "Baby Shark"? When did those "doo doo doo doo doo dooos" first penetrate your blood brain barrier? When did you oh so innocently think, "Huh, this is fun!"

If you're like most "Baby Shark" victims, that first time was likely not the last. According to YouTube statistics reported by the BBC, the Pinkfong music video recording of Baby Shark is now the most watched YouTube video of all time. Doo doo doo doo doo doo!

Surpassing 7.044 billion views, it has overtaken the 2017 Luis Fonsi jam, "Despacito," which was previously the most watched video with some 7.038 billion views. Suave, suavecito, indeed.

A longtime kids' summer camp song that's sort of just been in the ether, "Baby Shark" went big when the Korean kids' educational entertainment company Pinkfong put their catchy recorded version up on YouTube in 2016.

It gained popularity in South Korea, and doing the arm chomping dance became a viral challenge across the globe in 2017. The Baby Shark craze has continued to spread in the ensuing years, and no one's ears especially parents of young kids who insist on watching it over and over and over and OVER again have been the same since.

Baby Shark........ congrats.

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'Baby Shark' is now the most watched YouTube video of all time - Mashable

McAfee IPO: Not Worth The Limited Upside – Seeking Alpha

Editor's note: Seeking Alpha is proud to welcome Eric Gonzalez as a new contributor. It's easy to become a Seeking Alpha contributor and earn money for your best investment ideas. Active contributors also get free access to SA Premium. Click here to find out more

McAfee (NASDAQ:MCFE) launched its second IPO last week to a middling reception. As of this writing, the stock is down 20% from its IPO price. McAfee raised $740 million in the IPO, and it has a market cap of $8.1 billion after the first day of trading. Lead underwriters include Morgan Stanley, TPG Capital, and Bank of America Corp.

This poor reception perhaps summarizes McAfee as a whole. The company has had a middling decade ever since being bought by Intel (NASDAQ:INTC) for $7.7 billion in 2010 and then sold to private equity firm TPG a few years later. It struggled in its partnership with Intel, as the chip company never found a good use for an antivirus company, and McAfee watched other antivirus and cybersecurity companies surpass it. McAfee has basically stayed flat over an entire decade which has seen the tech market perform extremely well, and thus has largely been a failure.

McAfee is trying to re-market itself as a cybersecurity company which does more than sell antivirus software, but its poor reputation and finances should scare away investors. There are much more attractive IPOs or tech companies for your money, whether we are looking at the recent past or future.

McAfee these days is not a well-respected company. There are shenanigans surrounding its founder, John McAfee, who was arrested in Spain earlier this month on tax evasion charges. McAfee the founder currently has no connection to McAfee the company, but the company may take a small hit to its reputation.

The bigger problem is that to anyone with tech knowledge, McAfee is that annoying antivirus software which comes pre-installed whether you want it or not, causes more problems than it solves, and is far too difficult to uninstall. There is a tech argument that antivirus programs, whether we are talking about McAfee or Symantec (NASDAQ:NLOK) or another program, are entirely unnecessary and that relying on Windows Defender is good enough for most computer users.

Antivirus programs will still continue to be installed despite this argument, if for no other reason than that governments and businesses will use them to shield themselves from liability. But even if the antivirus market continues to grow, it is a crowded field and McAfee finds itself against competitors with a much better reputation.

These problems are unsurprisingly why McAfee has chosen to rebrand itself as a cybersecurity company which sells more than antivirus products. A cybersecurity company offers a wider range of protections such as a password manager and additional protections when conducting online shopping or banking. Cybersecurity is a field which is growing fast, with McAfee stating in its S-1/A that its addressable market is "projected to grow at a four-year CAGR of 7.9% and reach $41.2 billion in 2024." If it can re-market itself and improve its reputation, then McAfee could become a growing, valuable company.

The problem is that McAfee is neither growing nor valuable. According to McAfee's S-1/A, its revenue grew by 9.4% from 2018 to 2019 and by 8.5% from the first half of 2019 to the same time period in 2020 for a six-month revenue of $1.4 billion. These are low growth numbers for a tech IPO.

Furthermore, the aforementioned partnership with Intel and then TPG has left McAfee with a tremendous debt burden. As of June 27, 2020, McAfee has $4.6 billion in long-term debt and $7.8 billion in total liabilities. McAfee plans to use $525 million of its raised IPO proceedings to pay down a portion of this debt, which is a disappointing sign for investors who hope their funds will be used to pursue further investment.

This is not to suggest that there are no good financial news. McAfee's net income numbers are trending in the right direction, as the company recorded a net income of $31 million in the first half of 2020. Furthermore, gross profit has been steadily rising, and gross margin improved from 65% in 2018 to over 70% in the first half of 2020. But $31 million is nothing to boast of given this company's size, and its overall financial profile appears mixed at best given its middling growth. The company stands well below the Rule of 40 which is commonly used to measure tech companies.

The positive side is that McAfee is not heavily overvalued like many IPOs are. McAfee has a market cap of $8.1 billion, $4.6 billion in debt, and $257 million in cash. Calculate these numbers accordingly, and it has an enterprise value of almost $12.7 billion. If we assume a steady 9% growth rate from 2019, its 2020 revenue should be projected to be around $2.87 billion, which creates an EV/revenue ratio of 4.3. This is substantially lower compared to other, similar companies.

Despite its myriad problems, there is a path on which McAfee can be successful. If it can rebrand itself as a cybersecurity company instead of an antivirus company, it could start growing and become profitable again. The fact that it has a low valuation means that this could be a moment to buy low.

But that low valuation exists for a reason. In the present, McAfee is a company focused on the declining field of antivirus software, has not grown rapidly over the past few years, and is not profitable.

Cybersecurity is hardly a brand-new market, and yet McAfee has failed to take advantage of this new market to grow rapidly in the past. Why should investors expect that to change in the future? While McAfee has a host of new leadership such as CEO Peter Leav and CFO Venkat Bhamidipati, the two men have experience in working for established companies such as Motorola or Providence according to their backgrounds as reported in the S-1/A as opposed to raising a startup out of nothing with rapid growth. And what investors should want to see out of McAfee more than anything is growth and innovation.

There are far better cybersecurity companies on the market such as CrowdStrike (OTC:CRWD) or even Microsoft (NASDAQ:MSFT). If you are interested in McAfee, consider waiting until it can actually lower its debt load with other people's money or improve its revenue growth.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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McAfee IPO: Not Worth The Limited Upside - Seeking Alpha

Ripple CTO Explains Why Financial Institutions Are Reluctant to Adopt XRP in… – Coinspeaker

XRP has dropped approximately 17% while Bitcoin has rallied over 48% in the past twelve months.

As notable global financial players including PayPal Holdings Inc (NASDAQ: PYPL) recently enter the crypto industry, major digital assets have significantly benefited. However, XRP, which is heavily controlled by Ripple, lags behind as it continues to face regulatory clarity issues, especially in the United States. Last week Ripple CTO David Schwartz went to his Twitter page to explain the reason why financial institutions are reluctant to adopt XRP as a bridge asset.

The cry from the XRP community that continues to absorb Ripples market dump to fund the companys projects seems to be increasing by the day.

In its monthly escrow release, Ripple received 1 billion XRP. According to the Twitter bot @XRP_EscrowBot, Ripple locked back 900 million XRP and ended up with 100 million to dump into the market. This comes even after the company had previously indicated that there will be no more programmatic sales. As a result, Ripple eats away the majority of XRP market demand in expense of the retail customers.

At the time of writing, XRP was trading around $0.240632, having added approximately 2.8% in the past 30 days according to metrics provided by CoinGecko.

Notably, in the past 30 days, Bitcoin has rallied approximately 30% whereby at the time of writing it was trading around $13,671.67. Apparently, XRP has dropped approximately 17% while Bitcoin has rallied over 48% in the past twelve months, hereby attracting outrage from the XRP community over lack of market growth.

Schwartz was responding to a comment that likened his tweets to those of John McAfee, who has in the past made predictions that never materialized. In his defense, Schwartz said that he did not make any monumental prediction in his past tweets but instead clarified that they are in a wait and see game.

He indicated that there are hurdles that the company has to deal with to enhance XRP adoption.According to him, the company has done most of the technical work and only remains for the bank to adopt their system. However, with the lack of clarity on whether XRP is a security or a digital asset, its market adoption lacks the needed momentum.

Notably, Ripple recently partially won its lawsuit case in California but there remain about four of the initial charges to be ruled for the case to be completed.

In addition, Schwartz indicated that existing financial institutions are not using XRP for fear of reprisals from existing partners. According to him, financial institutions that are willing to use XRP as a bridge asset have zero customers since the product is new.

A financial analyst who sees positive income in both directions of the market (bulls & bears). Bitcoin is my crypto safe haven, free from government conspiracies.Mythology is my mystery!"You cannot enslave a mind that knows itself. That values itself. That understands itself."

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Ripple CTO Explains Why Financial Institutions Are Reluctant to Adopt XRP in... - Coinspeaker

Ripple CTO: What Are The Obstacles To The Company? – Somag News

Ripple CTO David Schwartz explained the obstacles to Ripples development in a post he made on Twitter. The Twitter feed discussed banks desire to use XRP as a bridge asset and various obstacles encountered in this regard.

David Schwartz suggested that banks use of cryptocurrencies such as Ripple (XRP) as bridge assets caused some problems. According to Schwartz, the use of bridge assets by customers to create new products leads to the need for new customers, which causes the company to develop more slowly.

A Twitter user posted an image of David Schwartz and John McAfee tweets. The image featured a 2018 Ripple CTO comment. In the comment, Schwartz said, It is too late for us to benefit. Our XRP strategy cannot wait that long. seems to say. David Schwartz replied to this post, in which his 2018 tweet was shared, on 28 October. In his reply, he said that he had just stated in the tweet that they would expect banks to adopt digital assets using their own initiative.

The Twitter user was surprised by the Ripple CTOs response and asked if there might be justified reasons for a bank wanting to use a bridge asset like XRP, but if he had any idea why they deliberately withdrew from the practice. David Schwartz replied without delay.

Schwartz explained the obstacles to banks further adoption of XRP as follows:

I think there are some obstacles. Regulatory uncertainty, last mile issues, fear of retaliation from existing partners, etc. Another important aspect is that the best customers will use bridge assets to create new products.

These clients are highly motivated to see the projects complete, and they want to offer the benefits of the projects to all clients. However, even if the products created in this case are 100% ready for use, they will have 0 customers because the product is new. So the problem is that gaining momentum is slow.

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Ripple CTO: What Are The Obstacles To The Company? - Somag News

Satoshi Nakamoto’s Bitcoin White Paper: A 12-Year Old Summary of Robust Unstructured Simplicity – Bitcoin News

Cryptocurrency supporters all around the world are celebrating the fact that today is the 12th anniversary of the Bitcoin white paper, a summary of the invention created by the pseudonymous inventor Satoshi Nakamoto. Bitcoins inventor published the paper on metzdowd.coms Cryptography Mailing list and ever since then, the financial world hasnt been the same.

12 years ago, Satoshi Nakamoto decided to let the world in on Bitcoin, the peer-to-peer electronic cash system that took the world by storm. The very first time Nakamoto published the paper was at 2:10 p.m. Eastern Standard, on metzdowd.com. Theres a lot we dont know about Bitcoins inventor and to this day the anonymous creators identity is still unknown. However, we do know that Nakamoto was a legendary genius and could have been a single person or even a group of people.

Bitcoins inventor specifically chose to publish the Bitcoin P2P e-cash paper paper on metzdowd.com mainly because of the Cryptography Mailing list, a pipermail message service that was operated by a group of visionaries and cypherpunks.

The cypherpunks had been trying to create reliable digital money since the 1990s and several experiments like Wei Dais b money circulated on the message service. We also know that Satoshi wrote the codebase for Bitcoin before the famous white paper was published.

Then on October 31, 2008, on the eve of Halloween, Satoshi wrote:

Ive been working on a new electronic cash system thats fully peer-to-peer, with no trusted third party.

The system Nakamoto created, has given birth to a massive counter-economy worth close to $400 billion, just in the market capitalization of all 7,000+ cryptocurrencies alone. Since the paper was first introduced, it has been cited 12,425 times to-date and mentioned in tens of thousands of articles during the last 12 years. Minus the papers citations, the Bitcoin white paper is 3,457 words in length and is composed of 16,686 characters excluding the arithmetic.

At the end of the paper, Nakamoto uses the term we, and stresses that the paper is a proposal that describes a system of electronic transactions without relying on trust.

Nakamoto added:

We started with the usual framework of coins made from digital signatures, which provides strong control of ownership, but is incomplete without a way to prevent double-spending. To solve this, we proposed a peer-to-peer network using proof-of-work to record a public history of transactions that quickly becomes computationally impractical for an attacker to change if honest nodes control a majority of CPU power.

Nakamoto then called the network robust in its unstructured simplicity. Of course, at that time when Satoshi published the white paper, nobody knew that the anonymous author literally developed the first working solution to the Byzantine Generals Problem.

Bitcoins creator knew that the infamous Byzantine Generals Problem, something that plagued computer scientists for decades, was officially solved and Nakamoto detailed this fact in some of the earliest messages to the community.

Of all the mysterious clues about Satoshis identity, the paper is one of the most succinct economic papers ever written. The white paper is so well crafted that many people think that it may have been written by another person, other than the online persona people communicated with until Dec. 2010.

Speculation aside, the paper gives a clear definition of the network and is considered a must-read for every cryptocurrency newb joining the counter-economy.

For some reason, on Halloween eve, Nakamoto felt the urge to tell the world there is a need for an electronic payment system based on cryptographic proof instead of trust. This in turn would allow any two willing parties to transact directly with each other without the need for a trusted third party. With the central banks creating money out of thin air, the need has never been more clear.

What do you think about Satoshi Nakamoto publishing the Bitcoin white paper 12 years ago today? Let us know what you think about this subject in the comments section below.

Image Credits: Shutterstock, Pixabay, Wiki Commons, The Bitcoin white paper,

Disclaimer: This article is for informational purposes only. It is not a direct offer or solicitation of an offer to buy or sell, or a recommendation or endorsement of any products, services, or companies. Bitcoin.com does not provide investment, tax, legal, or accounting advice. Neither the company nor the author is responsible, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of or reliance on any content, goods or services mentioned in this article.

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Satoshi Nakamoto's Bitcoin White Paper: A 12-Year Old Summary of Robust Unstructured Simplicity - Bitcoin News

Why Didn’t the Creator of Bitcoin Get Nobel? – Somag News

Did you know that Satoshi Nakamato, the creator of Bitcoin, was nominated for the Nobel Prize in Economics in 2016? Here are the details about the event

The anonymous person (s) named Satoshi Nakamoto, who is considered to be the creator of Bitcoin, was nominated for the Nobel Prize in economics in 2016. Satoshi Nakamato, nominated by UCLA professor Bhagwan Chowdhry, did not receive the award; because even his candidacy was not accepted.

The Royal Swedish Academy of Sciences has announced that it does not approve of the nomination put forward by the UCLA professor. The academy underlined that his candidacy could not be considered without revealing Nakamotos true identity. Official press officer Hans Reuterskild clearly stated that the award cannot be given to a deceased person, nor to an anonymous or anonymous person.

Oliver Hart and Bengt Holmstrom won the award that year, when Satoshi Nakamotos candidate was not even accepted, for their contribution to contract theory. If Nakamoto had disclosed his identity and was accepted as nominees accordingly, perhaps he could have been awarded the Nobel Prize in Economics and, in addition to the reputation it brings, the money award.

When Satoshi Nakamoto anonymously published his whitepaper, he could have predicted what might happen and the potential of what he created. When Nakamoto designed Bitcoin without a leader, he really wanted it to happen. According to most market experts, the decentralized structure could be damaged if Nakamoto was unmasked, and people could interpret Satoshis actions as an investment forecast, leading to unpleasant situations for the cryptocurrency community. For Satoshi Nakamoto, the creator of Bitcoin, this would probably mean pulling his own rope.

Although Bitcoin and its accompanying blockchain technology are opening many innovative doors in the world, they can also be used for malicious purposes. Many scams or illegal activities such as money laundering are carried out with Bitcoin. In such a scenario, governments could cause a series of legal troubles to Bitcoin creator Nakamoto. Satoshi Nakamoto is thought to prefer to remain anonymous for all these reasons.

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Why Didn't the Creator of Bitcoin Get Nobel? - Somag News

The Hoff claims to have invented Bitcoin in 12th anniversary video – Cointelegraph

Nine celebrities with profiles on the sponsored video-sharing platform Cameo have published messages wishing Bitcoin (BTC) a happy birthday ahead of the twelfth anniversary of the publication of its whitepaper on Oct. 31.

The videos were paid for by crypto security firm Halborn, and feature Hollywood notables, musicians, and comedians including David Hasselhoff, Charlie Sheen, Carole Baskin, Charlamagne Tha God, Gilbert Gottfried, Doug Benson, Hassan Johnson, Soulja Boy, and RZA.

Most of the celebrities were reading off talking points and showcased varying levels of crypto-literacy. Charlamagne Tha God questioned whether the pictures that he found upon Googling Satoshi Nakamoto actually depicted Satoshi.

Charlie Sheen offered praise to Satoshi Nakamoto and expressed excitement at the chance to invest in BTC once he finds a job of course. He admitted he has little knowledge of cryptocurrency.

The Hoff made the bold pool-side claim that he invented Bitcoin:

Tiger King star Carole Baskin emphasized the virtues of contact-less payments amid the coronavirus pandemic, predicting the virtual currency will be the future.

RZA wondered if maybe soon there will be a Wu-Tang Bitcoin.

While Oct. 31 commemorates the publication of the Bitcoin whitepaper, the networks genesis block was not mined until Jan. 3, 2009.

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The Hoff claims to have invented Bitcoin in 12th anniversary video - Cointelegraph

What industry leaders would wish for Bitcoins white paper 12th anniversary – Cointelegraph

While the crypto community decides whether Bitcoin (BTC) was born or merelyconceived 12 years ago, the fact is that Oct. 31, 2008, remains one of the most notable dates in humanitys modern history. Exactly 12 years ago, Satoshi Nakamoto published what some have described asa new bible Bitcoins white paper. Designed as a brand new purely peer-to-peer version of electronic cash, many see the creation of Bitcoin as a response to a global financial crisis.

Related: Happy birthday dear Bitcoin: Cryptos first white paper turns 12

Cointelegraphs video team talked to Adam Back, co-founder and CEO of Blockstream, about the birth of Bitcoin. Check out the video here:

Although Bitcoinhas recently become more appealing than both Jesus and sex, at least among Reddit users, lets not forget that its only Bitcoins 12th anniversary and that many great achievements and challenges still lie ahead, though for this real-world saga, we can only hope to know how this story will end and who will emerge as the victor.

Cointelegraph has reached out to Bitcoins friends and supporters, asking them to send their birthday wishes to the Big BTC.

Alex Wilson, co-founder of The Giving Block:

Muneeb Ali, CEO and co-founder at Blockstack PBC:

Michael Terpin, founder of Transform Group and BitAngels:

Jimmy Song, instructor at Programming Blockchain:

Alejandro De La Torre, VP of Poolin, a Bitcoin and cryptocurrency mining pool:

Efi Pylarinou, fintech and blockchain advisor:

Scott Melker, trader, investor and the host of The Wolf Of All Streets podcast:

Taylor Pearson, entrepreneur and author of The End of Jobs:

Jonathan Reichental, CEO of Human Future:

Sandra Ro, CEO of the Global Blockchain Business Council:

These quotes have been edited and condensed.

The views, thoughts and opinions expressed here are the authors alone and do not necessarily reflect or represent the views and opinions of Cointelegraph.

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What industry leaders would wish for Bitcoins white paper 12th anniversary - Cointelegraph

Investing with Bitcoin Trading – Euro Weekly News

In our generation, technology gets more and more advanced by the day. You cannot even be surprised now about online technology. A lot of people had already taken advantage of this, and you should, too. Let us introduce you to Bitcoin Trading.

What is Bitcoin Trading?

Bitcoin Trading is an online platform wherein you take profits by buying and selling cryptocurrencies. Cryptocurrencies is what you will earn in Bitcoin Trading. They are similar to money hence why they are also called digital money, future money, or virtual money.

Let me give you some starting info. Bitcoin started around the year 2007 but was successfully finished and updated during earlier 2009. Satoshi Nakamoto is the man behind Bitcoin. He still hides his identity with that pseudonym up till today; no one knows who he is and has yet to introduce himself.

Bitcoin was supposedly just an easier way for people to send money to their peers from different ends of the world. As time progressed, many have noticed this software and led Satoshi Nakamoto to update it. It has now become one of the best cryptocurrencies in which it also gained the title Mother of Cryptocurrency.

How does Bitcoin Trading work?

With its name, Bitcoin Trading, this basically means buying and selling as a form of income. You either trade or sell cryptocurrencies to people.

Keep in mind; Bitcoin does not have any third party involved with them. The government and banks do not acknowledge this software, so one bitcoins worth is not regulated. It can change from time to time, and we do not know how much ones cost will increase or decrease. With this situation, one bitcoin can cost $5,000 for a day, and then the next day, it can either increase for as high as $7,000 or drop down for as low as $2,000.

Now, to understand how it works. Once you have started a transaction, this will be gathered into blocks and will continue up until you keep transacting. We call this the Blockchain. This is a way for Bitcoin to keep track of all of your previous and current transactions. You can take this as your public ledger that is accessible by every person. This sets Bitcoin to a disadvantageous spot.

Imagine all your hard-earned cryptocurrencies to be gone swiftly without you even knowing when and who did it. Let me tell you, Bitcoin is volatile and would likely be prone to hackers. Do check your account from time to time or get help from a third party.

If you still encounter problems with Bitcoin, then you should more likely check out sites that can assist you. There are automated bots made solely for these cryptocurrencies. What these bots do is they take most of your work and even the part where you make decisions.

Cryptocurrency requires great decision making to earn more profits. That is exactly what these automated bots are best at. I can guarantee that bitcoin champion can help you with that.

Another good thing about these bots is that it can work a full day without it needing even a single break. Bots are not made like us humans. It does not hesitate for even a second and will continue to do its job trading and selling bitcoins. This gives us more opportunities to earn big profits and more trading.

Rest assured that all of these are not a scam. People still continue to pursue this as a way of getting a living, and it worked well on them. Bitcoin cannot support you with good transactions at all times. Be aware and make sure you are ready for the potential risks that you encounter.

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Investing with Bitcoin Trading - Euro Weekly News

In Pandemic U.K., Brexit Is an Afterthought, as Is Trump – The New York Times

LONDON When President Trump called the pro-Brexit politician Nigel Farage to the stage during his rally in Goodyear, Ariz., on Wednesday, it was a reminder that Britains bombshell vote to leave the European Union in June 2016 was seen as a harbinger of Mr. Trumps victory in the United States that fall.

And yet, four years later, Mr. Farages appearance seemed less a powerful display of populist camaraderie than a strange throwback. Britain has moved on from Brexit and Mr. Farage is viewed as yesterdays man, forced to travel abroad to seek a spotlight that has swung away from him at home.

Britain seems equally ready to turn the page on Mr. Trump. Despite his staunch support of Brexit and his effusive displays of affection for Prime Minister Boris Johnson, Mr. Trumps potential defeat next week is viewed by most Britons with equanimity, if not enthusiasm, given his unpopularity across the political spectrum.

There are millions and millions of Brits who voted for Brexit and think Donald Trump is ghastly and something quite different, said Timothy Garton Ash, a professor of European studies at Oxford University.

Even for those elite Brexiteers who had a vision of Britain and the U.S. creating an Anglosphere as an alternative to the E.U., its fairly clear that Donald Trump doesnt share that vision, he said.

Inside Mr. Johnsons government, where a Trump defeat has been a source of anxiety for months, officials now talk about how they could adjust to a President Joe Biden and perhaps even take advantage of a change in the White House. On their No. 1 priority an Anglo-American trade deal they say they could Bidenize whatever they have negotiated with Mr. Trump to make it palatable to a Democratic administration.

In foreign policy, diplomats spin visions of Britain standing alongside the United States in a coalition of democracies against the commercial and geopolitical pressure of autocrats in China and Russia. That is a role Mr. Johnson could never comfortably play with a president who relishes the company of strongmen.

They foresee Britain working with a Biden administration to tackle the global scourges of the coronavirus pandemic and climate change big-ticket projects that could elevate the Group of 7 summit of world leaders and the United Nations Climate Change Conference, which are to take place in Britain next year.

Its not as if the fundamental relationship is at risk, said Karen Pierce, the British ambassador to the United States. With any new administration, you have to show youre a good partner, and this is true regardless of whether its Democratic or Republican.

There is, to be sure, a healthy dose of rationalization in all this. A Biden administration would present Britain with a number of hurdles, starting with trade. Mr. Trump promised Mr. Johnson a lucrative deal, which the prime minister made a selling point in his own election campaign promising to Get Brexit done. But Mr. Biden has other priorities overseas and may not view a conventional free-trade agreement with Britain as much of a prize.

The British, some American experts said, were deluding themselves if they thought they could satisfy Mr. Biden by tacking on a couple of provisions on labor and environmental standards to their half-finished deal with Mr. Trump.

Its a little tone-deaf to say, We have this deal with Trump. What icing do you want on the cake to make it a Biden deal? said Thomas Wright, the director of the Center on the United States and Europe at the Brookings Institution in Washington.

Biden is going to want to demonstrate to the middle class that there is a different way of doing foreign economic policy, he said. I dont know if starting out with a traditional trade agreement is something theyre going to want to do.

The problem is, Britain cannot afford the luxury of starting negotiations from scratch. Trade Promotion Authority, the American measure that puts trade agreements on a fast track through Congress, will expire in July. In order to ensure a deal with Britain stayed on that fast track, the White House would need to notify Congress about it by next April.

Mr. Johnson risks stumbling into another difficult area with Mr. Biden over Ireland. His governments recent move to rewrite parts of its Withdrawal Agreement with the European Union that deal with Northern Ireland is viewed by Democrats in Washington as a threat to the Good Friday Agreement, a deal brokered by President Bill Clinton that settled decades of sectarian strife.

Mr. Biden has posted a tweet warning Mr. Johnson that any trade deal between the U.S. and U.K. must be contingent upon respect for the Agreement and preventing the return of a hard border. Period.

Nov. 2, 2020, 7:03 p.m. ET

British officials said they recognized the sensitivity of Ireland for Mr. Biden, who speaks fondly of his Irish roots. But those complications, analysts say, pale beside the thorny issues that could arise in a second Trump term when, for example, the president could decide to pull the United States out of the NATO alliance.

At Mr. Trumps rally, Mr. Farage framed the American election as a referendum on the forces that drove Brexit, as well as Mr. Trumps first victory. He recalled coming to the United States in 2016 to bring the Brexit message that you can beat the establishment, and that is what Donald Trump did.

Mr. Johnsons government has clung to some of that anti-establishment fervor. But the bitter debates that cleaved British society for three-and-a-half years after the referendum have subsided in part because of sheer exhaustion and in part because they have been eclipsed by worries about the pandemic.

Whatever the parallels between Brexit and Mr. Trump, the president has never enjoyed the affection of the British public. In a recent poll of European attitudes toward the election, the British favored Mr. Biden over Mr. Trump by a margin of 61 percent to 13 percent, according to the research group YouGov.

If Britain were to rerun the 2016 referendum today, Mr. Garton Ash said, polls suggested that Brexit would probably lose, too, if not by as thumping a margin as Mr. Trump might among Britons. But the vast majority of voters have no interest in revisiting the issue, which is why Mr. Farage has been left without a cause in a country where he once loomed large.

Exhausted by politics and besieged by the coronavirus, British voters seem attracted to some of the same qualities in Mr. Biden that American voters are.

There are lots of intelligent, skeptical voters in Britain who like the idea of Joe Biden, Mr. Garton Ash said. Most of them see their vote for Brexit as distinct and different from Trump.

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In Pandemic U.K., Brexit Is an Afterthought, as Is Trump - The New York Times

Brexit Negotiations to Continue This Week as EU, UK Push to Save Trade Deal – Insurance Journal

EU and British Brexit negotiators will continue talks in Brussels on Monday and until around mid-week, sources on both sides said on Sunday, in a sign both sides are still pushing to avoid a damaging breakdown in trade in less than nine weeks.

Intensive and secretive, the talks are a final bid to seal a new partnership agreement for when Britains transition out of the European Union runs its course at the end of this year.

If the sides overcome their differences, the new deal would govern everything from trade and energy to transport and fisheries. If they fail, an estimated $900 billion of annual bilateral trade in goods and services would be damaged from Jan.1 by tariffs and quotas.

An EU diplomatic source and a UK official said negotiations would continue face-to-face in Brussels on Monday following a full weekend of talks. An update on their progress and the chances of a deal was expected on Wednesday or Thursday, they added.

EU Brexit negotiator Michel Barnier said on Friday that much remains to be done to seal a deal.

Another EU diplomat following Brexit in Brussels told Reuters over the weekend that talks were still difficult on the most sensitive issues, including those of economic fair play, fishing rights and how to settle disputes in future.

Both sides have, however, previously signaled their readiness to compromise on fisheries a politically sensitive issue for both Britain and France, as well as several other EU states and Reuters reported on Oct.23 that Paris was already laying the groundwork to net a deal.

With time running out, financial markets and businesses are increasingly jittery as Britain and the EU face three main scenarios: a deal this year that salvages free trade, a tumultuous economic split, or a fudged arrangement that would settle future ties in a handful of areas but leave the rest up in the air.

(Reporting by Gabriela Baczynska; editing by Hugh Lawson)

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Brexit Negotiations to Continue This Week as EU, UK Push to Save Trade Deal - Insurance Journal