Black, Conrad Chosen to Receive Roeske Award < Yale School of Medicine – Yale School of Medicine

Two faculty in the Yale Department of Psychiatry have been chosen to receive the Nancy C.A. Roeske, MD, Certificate of Recognition for Excellence in Medical Student Education from the American Psychiatric Association (APA).

Carmen Black, MD, assistant professor of psychiatry, and Cynthia D. Conrad, MD, PhD, clinical instructor in psychiatry, are the 2023-2024 recipients of the award at Yale.

The award was established in honor of Nancy C.A. Roeske, MD, and serves as a tribute to her unique and creative contributions to psychiatric education. It is awarded to APA members who have made outstanding and sustaining contributions to medical student education.

Black is director of Social Justice and Health Equity Education in the Yale Department of Psychiatry and a Yale School of Medicine Clinical Skills Lead, where she teaches pre-clerkship medical students about patient interviewing and the physical exam. She is leading the medical school in a medical education grant about removing carceral practice within medical education and clinical practice. In this capacity she teaches a core clerkship lecture about historically informed, evidence-based principles supporting the de-policing of hospital medicine.

Conrad has served as a psychiatric residency training director and conducted case conferences on complex patients with the Connecticut Department of Mental Health and Addiction Services. She tutors medical students during their psychiatric clerkship, stressing the value of biopsychosocial approach to patient care. She assists her students in oral and written case presentations, differential diagnostics, treatment, and disposition planning.

Submitted by Christopher Gardner on February 02, 2024

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Black, Conrad Chosen to Receive Roeske Award < Yale School of Medicine - Yale School of Medicine

High school females get hands-on orthopaedics experience at WVU’s Perry Initiative event – West Virginia University

More than 30 young female high school students were able to work alongside West Virginia University orthopaedic clinicians and educators to participate in a transformative experience at the School of Medicine through The Perry Initiative.

Michelle Bramer, M.D., led the team of volunteers (see full list at the bottom of the article) to orchestrate a one-day career exploration event on Saturday, Dec. 9, as part of the Perry Outreach Program.

The Perry Initiative collaborates with medical centers, universities and high schools to organize Perry Outreach Programs for high school girls. These day-long events, conducted at over 45 locations nationwide, involve participants in simulated orthopaedic surgeries, biomechanical engineering experiments and insightful sessions with accomplished women engineers and surgeons.

Organizers say that the event benefits the faculty as much as the students.

In dedicating our time, expertise and passion to this initiative, my team and I firmly believe that the benefits extend beyond the students, positively impacting the faculty as well, said Dr. Bramer, M.D.

Organizers say students become mentors and role models, guiding attendees through the intricacies of suturing, casting, surgery and more, fostering confidence and opening doors to STEM-related careers for young women.

For more information on the WVU Department of Orthopaedics, visit medicine.wvu.edu/orthopaedics.

Full list of volunteers:

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High school females get hands-on orthopaedics experience at WVU's Perry Initiative event - West Virginia University

New Professors in the Department of Internal Medicine – Yale School of Medicine

Education:

BS, Pennsylvania State University

MD, Sidney Kimmel Medical College at Thomas Jefferson University

This is truly an honor and a culmination of decades of work dedicated to advance the field of cancer genetics. To have this appointment at an esteemed place such as Yale is even more meaningful, which has global reach and impact. I think the work I have done in collaboration with so many colleagues nationally and globally regarding cancer genetics, cancer disparities, and access to genetics care is critical at this time in oncology. Having the appointment based on this work really feels fulfilling and inspiring to continue this important work.

I contacted my husband, young adult kids, and parents who all congratulated me. Having that level of appreciation from my family, especially my children, was so moving.

I have been blessed to work with so many expert colleagues this really is a team approach to advance cancer care! I am honored to have mentored and continue to mentor the next generation of physicians and physician-scientists. Ultimately, I am deeply grateful to all of my patients who inspire my work. When I hear of even one patient who has been touched by my work, that is all I need to feel that it is all worth it.

I truly enjoy the opportunities to work with colleagues across disciplines, geographic regions, and expertise. I appreciate the ability to have creative freedom to explore new lines of research based on patient needs, which have led to some of the most impactful contributions. I also enjoy teaching and mentorship to build a legacy to carry forward for generations.

My high school mascot was the bulldog and now my career mascot is also the bulldog! I have come full circle here at Yale.

BA, BS, Trinity University

MD, PhD, University of Texas Southwestern Medical School

It is helpful to contextualize the promotion by placing it into a sequence of ~100-month blocks from (1) grade school through middle school, (2) high school and college, (3) MD-PhD education, (4) internship, residency, and fellowship training into K08 award, (5) first R01 grant through associate professorship, and (6) tenure until professorship. It is with a gentle sigh of relief, as I approach my 660th month on this planet, that I have at long last completed my "official" training. It is with much excitement, humility, and sentimentality that I look forward to the centennial blocks to follow this time without training wheels or institutionalized goals. It is in these segments where I hope finally to perform what I have been educated to do. I am told it is during these times when wisdom starts to engraft. Fingers crossed.

It still hasnt quite hit that I have been promoted. Seriously. I am actually a bit afraid to do or say anything for fear that it is just a dream and will disappear when I awake. While I had a perfect evening getting takeout with my lovely wife, Ania (I got to choose the pizza toppings!), I wont let loose until after learning the secret handshake and receiving the key to the clubhouse. That said, we did pop some bubbly with our neighbor Katie, who, coincidentally, was promoted to professor the same day big news for our block!

An awkward and stubborn persistence. Somewhere along the way, my great discovery was an internal doggedness that was supported by a loving family and absolutely amazing team. This doggedness was woven into a network of remarkable colleague-friends and sustained by sage mentors, serene gurus, and sentient leaders. Everything else follows.

The science, equations, and relationships.

Both my parents have full heads of hair.

The Department of Internal Medicine at Yale School of Medicine is among the nation's premier departments, bringing together an elite cadre of clinicians, investigators, educators, and staff in one of the world's top medical schools. To learn more, visit Internal Medicine.

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New Professors in the Department of Internal Medicine - Yale School of Medicine

Nobel Laureate and World-Renowned Geneticist to Speak at 2024 Commencement – News Center – Feinberg News Center

Michael S. Brown, MD, director of the Jonsson Center for Molecular Genetics and the Regental Professor at the University of Texas (UT) Southwestern Medical School, will address graduates and their guests at Feinbergs 165th commencement ceremony on Monday, May 13.

Brown, along with his long-time colleague, Joseph Goldstein, MD, Chairman of the Department of Molecular Genetics at UT Southwestern Medical Center, discovered the low-density lipoprotein (LDL) receptor, which controls cholesterol in blood and in cells, and showed that mutations in this receptor cause Familial Hypercholesterolemia, a disorder that leads to premature heart attack.

Their work laid the groundwork for the development of statins that block cholesterol synthesis, increase LDL receptors, lower blood cholesterol and prevent heart attacks. Their discoveries earned them the Nobel Prize for Medicine or Physiology in 1985 and the U.S. National Medal of Science in 1988, among many other awards.

Brown earned his MD from the University of Pennsylvania School of Medicine in 1966 and completed an internship and internal medicine residency at Massachusetts General Hospital in 1968. He then became a Clinical Associate at the National Institutes of Health and in 1969, he joined the laboratory of Earl Stadtman at the National Institutes of Health as a postdoctoral fellow. In 1976, Brown was named the Paul J Thomas Professor of Medicine and Director of the Center for Genetic Diseases at UT Southwestern Medical School.

Brown and Goldstein have shared a laboratory for more than 50 years. The two scientists worked with scientists at Merck to develop the first statin drugs, which cause the liver to produce more LDL receptors, thereby removing more LDL from blood and lowering LDL levels. In 1987, Merck received FDA approval for the first statin drug, which was shown to effectively treat high blood cholesterol, reduce heart attacks and extended survival in adults with coronary heart disease. Today, statins are taken by more than 20 million Americans.

Brown is a member of the U.S. National Academy of Sciences, the National Academy of Medicine, the American Philosophical Society, and the American Academy of Arts and Sciences, and he is a Foreign Member of the Royal Society in London. Brown served for 16 years on the Board of Directors of Pfizer and is currently director of Regeneron Pharmaceuticals, where he chairs the Technology Committee.

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Nobel Laureate and World-Renowned Geneticist to Speak at 2024 Commencement - News Center - Feinberg News Center

SEMO and St. George’s University start partnership to support medical students – The Arrow

SEMO medical students practice injections.

Photo by Polina Kondrashova

SEMO students who are considering a career in medicine now have more opportunities for academic and personal development. SEMO has just entered a partnership with St. George's University, a school in Grenada, West Indies, that will allow outstanding medical major students to continue their studies and advance their progress.

SEMO executive director of International Education Kevin Timlin shared more information about the partnership and its benefits for students.

St. George's agreement gives SEMO pre-medical students an automatic admission into their [St. Georges University] MD program, if they complete our pre-medical program with a 3.4 GPA and a 3.5 GPA in their science courses, Timlin said.

This agreement was established to help students get a medical degree, which is usually challenging. The partnership aims to attract hardworking students to offer them financial and moral support.

I think U.S. medical schools are very, very strict. They're rigorous, they're stressful, and they have a model in which people burn or weed out, Timlin said. In St. George's University, they have a much more student-centric model, in which they provide counseling, they provide support, they provide a different kind of environment where they're not trying to get people burnt out.

St. Georges University is interested in recruiting and supporting students who are motivated to become qualified physicians or veterinarians. Their main goal is to help students successfully finish medical programs.

They take care of their students, and they really monitor their progress, Timlin said. And what I would say is they've developed a process for their medical schools that helps them identify people who are going to be qualified and good physicians, and a model to support them in their program in order to get them through the medical school.

For SEMO, this agreement means more opportunities for pre-medicine and pre-veterinarian programs. The dedication of SEMO students and staff became a fundament for building this partnership.

I want to stress we are the only university in the state of Missouri that has an agreement with St. George's, and one of only approximately 40 in the entire U.S., Timlin said. They vetted our pre-medical program and biological sciences program, looked at the faculty members, courses, qualifications, outcomes, and recognized our program as being one that successfully prepares people for this environment.

According to the SEMO website, accepted students will receive a $10,000 scholarship to complete their studies at St. Georges University.

Sophomore biomedical science major Vanesse Mungate, who recently applied for the program, says that it will help her achieve her professional goals.

I'm an international student here in the U.S., and it's very hard for international students to get placements. You need to have extremely, extremely high GPA, and medical school is expensive, so you need to have a good financial status, Mungate said. Compared to schools in the U.S., you're getting education, but at a more affordable price.

Getting experience in and outside of the United States is another benefit of the program.

The biggest factor for me is that a lot of upcoming doctors here in the U.S. can be coming from St. George's, which is a good thing because if you get into the medical field, you might need some references. And that would be a good start. Mungate said.

According to the SEMO website, SEMO and St. Georges University entered the agreement in December 2023. As the partnership is new, a limited number of students are participating.

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SEMO and St. George's University start partnership to support medical students - The Arrow

Relationship between individual and country-level socio-economic background, USMLE step scores, and … – BMC Medical Education

In this study of 744 IMGs applying for the 2022 residency match, we found that younger age, higher USMLE scores, higher-income country of origin (including the United States), fewer match attempts, applying to fewer specialties, having parents with college degree or higher, and coming from higher-than-average or lower-than-average family income were associated with increased odds of matching. Gender, personal income, and visa status did not demonstrate significant associations with residency match.

According to the NRMP in the 2022 residency match 5,048 US IMGs and 7,864 non-US IMGs submitted rank lists [2]. Thus, surveys for this study were sent to 38% of all IMGs who applied to the 2022 match with 5% of all IMGs participating in 2022 residency match responding. To our knowledge, only a limited number of studies focusing on IMGs residency match exist. Most of the data comes from the annual NRMP report.. This information is limited to data such as USMLE scores, research publications, work and volunteer experiences, and number of specialties applied. There are, however, papers focusing on specific economic and cultural challenges of IMGs demonstrating that IMGs from more developed countries match to more competitive specialties and residency programs [13, 14].

Our study cohort had a higher proportion of successfully matched applicants (87.3% of US IMGs, 70.5% of non-US IMGs) compared to the total population of applicants per the NRMP which reported a match rate of 61.4% for US IMGs and 58.1% for non-US IMGs in the 2022 residency match. Similarly, our rate of match to the preferred specialty was higher with 68.9% of US IMGs and 63.8% of non-US IMGs matching to their preferred specialty compared to the 2022 match rate to preferred specialty which was 54.8% for US IMGs, 53.5% for non-US IMGs [2]. Despite these differences, we still had a substantial proportion of unmatched non-US IMGs which allowed us to perform a multivariable analysis of factors associated with matching. Other than a higher match rate in our cohort, the rest of the reported variables, including Step scores and percent of female applicants, were similar to national average based on the NRMP data. This suggests that the data likely can be generalized to the other residency programs in the US. Our analysis of US IMGs was limited due to the small number of unmatched applicants in our cohort. Findings demonstrated that graduates from countries with high or upper middle income were more likely to secure residency position, and applicants with at least one parent with a college degree or higher were more likely to match to a program listed in one of the top-3 spots on their rank list.. IMGs from higher income families were also more successful in residency match. This supports our theory that IMG applicants from higher socio-economic backgrounds were more likely to secure residency positions even when accounting for other variables. Higher socio-economic status is also associated with medical school matriculation among American medical students. A 2018 AAMC study of 126,856 1st year US medical students from 1988 through 2017, the top two household income quintiles contributed between 73 and 79% of all US medical school matriculants each year. Interestingly, matriculants in higher-income quintiles were also more likely to be children of parents with at least a bachelors degree [5]. Regarding parental education, there are similar findings among US medical students. In 2022 only 21.5% of US medical school matriculants had parents with less than a college degree [15].

Our study did also demonstrate an association between being from a lower-than-average income family with higher chances of matching. While this result seems to contradict another finding of our study, it is possible that both are true. Admittedly it is very difficult to compare between residents of different countries since family income is self-reported and potentially subjective. However, with an increasing focus on diversity, resilience and grit in the residency selection process, applicants from lower-income families may have an advantage in demonstrating these qualities. The true association between family income and residency match success requires further study.

Per our data, age was significantly associated with chances to match, match to preferred specialty, and top-3 programs. Younger applicants do better in all three outcomes. The average age of a first-year medical resident in the US is 29.8years [16], the average age of matched IMG in our dataset was similar (28.9years).

In addition to the finding of applicants from higher income countries being 66% more likely to secure residency position, there is another observation. Approximately 10% of the worlds population comes from low-income countries [17]. Among our non-US IMG respondents only 5.7% reported being from a country classified as low-income by the World Bank. This underrepresentation could be due to financial barriers faced by these applicants.

There are programs in the US medical education, such as VSLO (Visiting Student Learning Opportunities) which charge different annual fees depending on a countrys income level [18]. The ECFMGs fees, however, are the same for every IMG. The fees are lower for IMGs residing in the US because they do not pay an international surcharge for the USMLE exam administration. In addition, USMLE examinations are less likely to be available in low-income countries, requiring applicants from these countries to travel internationally to sit for each exam which further increases the relative cost of the match for them [17]. The COVID-19 pandemic likely widened the gap between IMG applicants from different countries even more, starting with economic damages disproportionally affecting low-income countries and ending with new regulations complicating international travel especially for nationals of countries where Western vaccines are not readily available and those requiring US visas [19, 20].

We found that the increased number of specialties applied to was associated with a decreased odd of matching. This finding is consistent with NRMP reports demonstrating that applicants applying to a higher number of specialties have lower chances of matching. This finding may be due to residency programs perceiving applicants with multi-specialty CVs as having lower commitment to any given specialty. Alternatively, applicants applying to more competitive specialties are more likely to use less competitive specialties as a secondary option. Further specialty-specific studies are needed to analyze these findings.

Visa status was not associated with odds of matching. This is likely because our institution sponsors all types of visas for IMGs, however, this finding may not be generalizable to other institutions where only particular types of visas are sponsored.

To improve access to US graduate medical education for international applicants from lower socio-economic backgrounds, consideration of a sliding scale payment system for the variety of fees associated with the entire process could be introduced. Additional studies are needed to survey larger number of international applicants regarding the financial barriers they experience to entering the US graduate medical education system prior to developing this type of system.

Based on our data, any IMG applying to the NRMP would be advised to put their absolute best application forward the first time rather than taking a shot and seeing how they fair. Age was also a significant predictor of match success so waiting many years to apply could offset some of the gains in other areas. For those applicants who are further out from their primary medical training, they may need to find additional ways to connect with or highlight their value to programs to demonstrate how their prior experience is an asset and not a liability, since our data suggests a preference for younger applicants. We acknowledge that this finding could be the result of older applicants having more attempts due to weaker applications within our data set. It is also possible that applicants from lower socio-economic backgrounds are not able to apply shortly after medical school graduation as they might need to work for several years to be able to afford the USMLE and NRMP cost.

This was a retrospective study in order to comply with ERAS policies. Our response rate was relatively low at 15.13% but does represent 5% of all IMGs applying for 2022 residency match. This is still a relatively small sample compared to the number of IMGs applying for residency match each year. An unmeasured confounding is a potential limitation of this study. Due to difficulties with comparing socio-economic characteristics of people from different countries, we had to use subjective variables such as personal perception of the participants of their level of income growing up in comparison to other families in the same city. The match rate of our respondents was higher compared to the total population of applicants per the NRMP which could represent self-selection bias. There is a small chance all associations identified were due to statistical error.

We used contact information provided by the applicants as a part of NRMP. Based on our sample, more than 1/3 of all IMGs applying that year applied to our institution, they also likely applied to hundreds of other programs, and therefore, we do not believe that competitiveness of our institution was a significant limiting factor of this study, although it is a possibility.

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Relationship between individual and country-level socio-economic background, USMLE step scores, and ... - BMC Medical Education

Gov’t expected to announce medical school quota hikes this week – Yonhap News Agency

SEOUL, Feb. 4 (Yonhap) -- The government is likely to announce an increase in the medical school enrollment quota this week to address the shortage of doctors in remote areas and essential medicine despite strong opposition from the medical circle, officials said Sunday.

If decided, it will be the first hike of the medical school enrollment quota in 19 years. The current limit stood at 3,058.

The government has reportedly been looking to raise the annual enrollment quota at medical schools by as much as 2,000 from the current 3,058, starting in 2025. The move comes amid a shortage of doctors in non-metropolitan and remote areas, as well as in the essential medicine field, including pediatrics and emergency care.

Doctors have opposed the government's plan, claiming that the quota hike will compromise the quality of medical education and services and that the government should find other ways to better allocate physicians and boost compensation.

Health Minister Cho Kyoo-hong speaks during a press briefing on medical reform issues at the government complex in Seoul on Feb. 1, 2024. (Yonhap)

During a government-public debate on medical reform Thursday, health officials said the government will raise the number of medical school students starting in 2025, considering the shortage of 15,000 doctors in 2035.

At the session, President Yoon Suk Yeol vowed to push ahead with the expansion of medical personnel, saying it is essential to reviving local and essential medical services.

Along with the potential quota increase, the government plans to announce a set of measures that aims to encourage doctors to major in essential medical fields and serve in non-metropolitan and other remote regions that have particularly seen a decrease in the number of medical staff.

According to the health ministry, the number of doctors per 1,000 people in South Korea came to 5.6, far below the average of the Organization for Economic Cooperation and Development member nations.

julesyi@yna.co.kr (END)

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Gov't expected to announce medical school quota hikes this week - Yonhap News Agency

Research Forum Showcases 95 Medical Student Projects – Jacobs School of Medicine and Biomedical Sciences – Jacobs School of Medicine and Biomedical…

Student(s) Project

Ademola Adegbemigun

Patient Skin Radiation Dose During Transcatheter Aortic Valve Replacement

Daniel Adelsberg

Risk Factors for Nasogastric Tube Feeding Failure Following Oral Squamous Cell Carcinoma Resection

Christina Andreou

Enrichment of Neuroblastoma Cells from Peripheral Blood Stem Cells of High-Risk Patients

Eylon Arbel

Colpectomy Reduces the Incidence of Urethral Fistula and Stricture Formation in Female-to-Male Gender Affirming Surgeries: A Meta-Analysis

Michael Augustin

Perception of Sunscreen Need and Affordability in the Buffalo Area

Beatrice Bacon

University at Buffalo DoctHERS (AMWA): Female Mentorship Pilot Program

Daniel Baetzhold

Buffalo Food Resources Needs Assessment

Mohamed Bah

Single Surgeon Unilateral Pedicle Screw Transformational Lumbar Interbody Fusion: Experience of More Than 100 Patients With Long-Term Follow-Up

Madison Ballacchino

Determining the Benefit of Frailty Scoring in Post-Operative Outcomes

Claire Beecher

Health Care Worker Education for Palliative Care in Africa

Perya Bhagchandani

Comparative Genomic Analysis of Autoimmune Diseases With Pemphigus Vulgaris

Walker Black

Complement Signaling as a T-Cell Checkpoint in Ovarian Cancer Microenvironment

Fernando Bomfim

Exploring Feasibility and Interest in Inegrated Urology-Transplant Surgery Training Programs in the United States

Jamie Bousleiman

Perceptions and Understanding of Parental Leave During Orthopedic Surgery Residency

Brayan Calle Gonzalez

Identifying Cell Processes Involved in Corneal Endothelial Cell Injury from Phacoemulsification

Deana Chan

Seizure Following In-Office Administration: A Case Report and Literature Review

Lauren Chavanne

Cardiac Arrest Pearls for Survival (CAPS): A Quality Improvement Initiative to Enhance Resident Education

Alexandra Corbin

YouTubes Role in Empty Nose Syndrome Education

Gaby Cordero

Barriers to Longitudinal Community Service in Medical Education

Chloe Cottone

Supraclavicular Artery Island Flap for Head and Neck Reconstruction: Our Experience and Factors Predictive of Complications

Patrick Crossen

An Interprofessional Education Model to Provide Free School Sports Physicals to Underserved Communities

Ashtah Das

Not All Frailty is Equivalent: Comparing Frailty Index Scales in Their Capacity to Predict Mortality in Older Adults with Traumatic Brain Injuries

Erika Davidson

Modulation of the Chenokine Production in Colorectal Cancer Tumor Micro-Environment

Abbigail Delmonte

Elevated Liver Enzymes at the Time of Deceased Donor Organ Donation Do Not Affect Recipient or Pancreas Allograft Survival Following Pancreas Transplantation

Peter Demjanenko

Effects of SOS-Inhibiting Compounds on Protein and Nucleic Acid Release in Gram-Negative Bacteria

Nadine de Nijs

Assessing the Influence of Therapy Dogs on Mental Health and Well-Being Among Medical Students

Kendall DeSantis

Is Coronal Alignment Overcorrection a Risk Fsctor for Revision in TKA?

Alexandra DiVasta

A Qualitative Study of Patient Treatment Preferences and Willingness to Enroll in a Randomized Controlled Trial Among Primarily African American Patients With Knee Osteoarthritis

Katelyn Donnelly

A Qualitative Analysis of North American Medical Students Perspectives on the Impact to Medical Education of Dobbs v. Jackson Womens Health Organization

Sabrina Dunn

Identifying Factors that Contribute to Delays in Stroke Treatment: An Analysis on Atypical Stroke Symptoms.

Tara Edwards

Determinants of Breastfeeding Among Ex-Smoking Mothers

Jade Edwards

Egg Consumption During Pregnancy and Risk of Gestational Diabetes

Sinan Ersan

The Effect of Teprotumumab Infusion on Ocular Alignment in Patients With Symptomatic Thyroid Eye Disease

Ifeoma Ezeilo

Relationship Between Sleep Disturbances and Neurodegenerative Markers in Older Veterans

Farangis Farsio

Mandibular Reconstruction of Hemifacial Microsomia in Goldenhar Syndrome: A Case Report and Review

Hendrick Francois

Sagittal Deformity Correction With Schwab 4 Osteotomy and Patient Reported Outcomes

Gabriela Funez-dePagnier

Maternal Neonatal Health Outcomes of an Integrated Obstetric Care Model in a Multicultural, Underserved Population

Karlie Gambino

Effects of an Optimal Default Grocery Shopping Intervention on Dietary Intake: Exploring the Role of Food Source

Erin Gawel

Current Diagnosis and Management of Cervical Non-Tuberculous Mycobacterial Infections in Children

Sabrina George

Juvenile Idiopathic Arthritis Genetic Risk Haplotypes: Relevance to Children of African Ancestry

Jason Gershgorn

Diversity Among EMS Fellows

Adam Greenstein

Comparison of Percutaneous Cryoablation vs Microwave Ablation of Small Renal Masses in a Large Community Hospital Setting

Eisa Hashmi

Aurora Surgiscope for Minimally Invasive Evacuation of Intracranial Hemorrhages A Preliminary Institutional Experience

Victoria Hoffman

Association Between Psoriasis with Depression in U.S. Adults: Data from the National Health and Nutrition Examination Survey 2005-2014

Holly Houenstein

The Role of the Microbiome in Chemotherapy-Associated Oral Mucositis

Nathaniel Iskhakov

Addressing Disparities in Kidney Transplant Outcomes: Insights From Lupus Nephritis Patients on Race, Gender, and Donor Sources

Sydney Johnson

Preliminary Evaluation of the Two Patient-Centered Educational Videos About Kidney Transplant Complications

Koulako Kaba

Creation of and Preliminary Analysis of Mutants in Two Low Molecular Weight Penicillin Binding Proteins, 5/6 and 6b in the XDR Acinetobacter Baumannii Clinical Isolate Ab834

Alaina Kenny

Auricular Erythromelalgia: A Survey of Patient Experiences

Joshua Kent

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Research Forum Showcases 95 Medical Student Projects - Jacobs School of Medicine and Biomedical Sciences - Jacobs School of Medicine and Biomedical...

President Costin speaks at LUCOM Convocation, urges medical students to represent Christ in their careers | Liberty … – Liberty University

(Photos by Matt Reynolds)

Speaking to a room full of student-doctors at Liberty University College of Osteopathic Medicine (LUCOM) on Wednesday during the medical schools weekly Convocation, Liberty President Dondi Costin emphatically shared the importance of not delaying Gods purpose for their lives.

Costins message marked the conclusion of LUCOMs Convocation series titled Waiting on God, and he stated that his message to the student-doctors is simply that God is also waiting on them.

The Lord is waiting on you to become the man or woman of God He wants you to be, and God loves you, he said. God loves you not because youre talented or ambitious or have a special calling you wouldnt be here if you werent but because He made you in His image. He loves you with an everlasting love that is based not on your performance but based on His performance.

Costin is a retired Major General with 36 years of service in a military career that culminated as a senior leader in the Pentagon, where he served as the 18th Air Force Chief of Chaplains. He said during his time in service, he would wake up every morning, don his uniform, and take note of the words on his right shoulder.

When Id put that thing on, button up those buttons, and look at myself in the mirror before I left for the day to conquer the world or whatever else I was supposed to do, I would see the name U.S. Air Force on my shoulder, and that told me that my job that day was not to live for myself, but to give everything I could for the U.S. Air Force. My oath said nothing about having a nice life it was all about how much I would be giving to those who would never know my name or care (about me), but they would care that they could go to sleep each night in a free country and wake up in a free country.

He asked those in the room why they wanted to become a doctor and theorized that some may have been pushed into it by loved ones and others might have heard that the profession makes a lot of money. However, just as he was called to serve in the military, Costin said that the student-doctors likely also heeded a call to their profession and knew there are people out there who are in a state of pain and difficulty that they want to serve.

On the opposite shoulder of his uniform, Costin said, was his last name. While he did nothing to earn his last name, Costin said he would make a point each day to represent his name well.

When LUCOM students put on their own uniform of a white coat, Costin said, they are a representative of their names, too, sewn onto the chest with the title of Dr.

When people come to you, theyre not going to ask to see your transcripts and (references); you are going to walk in with an authority based on your Dr., he said. The most important thing about your title is not what it means to other people its the meaning you put into the name. If you learn to wait on God, you will do exactly what He says and help the people who cried out to Him for help.

But doing so can only come with the choice to submit to God and not make excuses before answering His call. Costin referred to the story in Exodus of Moses resisting Gods call through the burning bush for him to free His people, along with Costins own experience of initially rejecting a calling to ministry, as he charged LUCOMs student-doctors to not waste time God can use.

Waiting on you is one of His specialties, and let me tell you from personal experience: the sooner you take Him up on His offer to go wherever He wants to send you, the better your life will be, and the better the lives will be of the people He has called you to serve, Costin said. The thing Ive learned about God is that He will let you run, and when you falter, He will be there waiting for you. Although others will say this, God will never say, I told you so. He will say, Its about time, and there are people out there who need you.

At the closing of Convocation, LUCOM Dean Dr. Joseph Johnson, DO, asked faculty and students in leadership or with military backgrounds to lay hands on and pray over President Costin in his leadership of Liberty University.

The next series for LUCOM Convocation, The Great Physician, will begin next Wednesday, Feb. 7. Speakers for these Convocations are often faculty and staff from LUCOM or other departments of Liberty, but they also feature outside speakers on occasion.

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President Costin speaks at LUCOM Convocation, urges medical students to represent Christ in their careers | Liberty ... - Liberty University

Anatomy Memorial at OUWB honors those who donated their bodies to med ed – News at OU

Neel Patel has learned a lot during his first year as a medical student at OUWB, but one moment will stick with him for the rest of his life.

It was the first time he held a human heart in his hands.

Part of a lesson on cardiology in the schools anatomy lab, Patel said it wasnt lost on him that a woman had donated her body to science so that he and others could learn and one day treat countless others.

He reflected similarly on Monday, during the 2024 OUWB Anatomy Memorial, when he read a poem he wrote called Heartfelt Legacies.

This heart was better than any textbook. This heart was the fuel I needed, said Patel. It powered my heart. My heart for medicinefor cardiology. I thank the woman whose heart I held. She is a heartfelt legacy.

Patel read the poem to about 130 others who attended the ceremony held at Oakland Universitys Oakland Center. The annual event is hosted jointly by OUWB and the Oakland University School of Health Sciences Physical Therapy program.

Both programs rely on such donors as part of their curricula. Students begin working with the donors at the beginning of the school year. They are considered vital to providing students with hands-on learning experiences and the ability to see the diverse variations of the human body.

The donors also are considered the students first patients.

And their donations carry tremendous meaning to students like Patel, whose father has recently been facing his own heart issues.

Neel Patel, M1, read a poem called "Heartfelt Legacies."

Its really personal to me, said Patel after the memorial. With everything that my father has been going through recently, I had the chance to see exactly what was happening in the lab and almost in real time.

The experience we get in the lab is like nothing you can get anywhere else, he added.

Other speakers at the event included Stefanie Attardi, Ph.D., associate professor, Department of Foundational Medical Studies; Brandon Metcalf, M.D., OUWB 22; and Christopher Carpenter, M.D., Stephan Sharf interim dean, OUWB.

Carpenter acknowledged the selfless act of the donors. He reflected on his own first experiences in an anatomy lab, and how he still vividly remembers it.

I was understandably anxious, but also humbled and filled with respect for the person in front of me who donated their body for our education, he said. As a student, its hard to imagine how your body donors help shape your lives after medical school, but they do.

You will never know all of the reasons why they wanted to be in the lab with you, but I am pretty sure that they wanted to help you be the best at your profession, he continued. They wanted you to succeed.

Students like Patel from both programs chose to pay tribute via art.

M1 Sophie Dixon was among the speakers who all set a flower on a table prior to their turn at the podium.

Kristen Cumming, a PT student, presented Interpretation of Human Movement, a video from her time as an undergrad featuring the Grand Valley State University Laker Dance Team.

OUWB M1 Bennett Hendricks performed Augustin Barrioss Julia Florida on guitar.

M1 Sophie Dixon presented a painting called The Gift of a Heart, and M1 Myra Esmail read a collection of quotes from OUWB students and staff all expressing gratitude to the donors.

Malli Barremkala, M.D., associate professor who teaches anatomical sciences to first- and second-year medical students, said the memorial was beautiful and that it helps him better understand how students process working with the donors.

Further, he said he hopes the memorial helps people understand that the lab experience is not just for learning anatomy.

We sometimes hear the term hidden curriculum and the anatomy lab is the perfect place for hidden curriculum, said Barremkala. Students are learning how to deal with a patient, how to communicate with their peers about a patient, and how to communicate with faculty.

And its all happening in what I feel is a sacred place, he added.

Other memorial attendees also talked about what the donors meant to them after the event.

I really appreciate the gifts that the donors gave us so that we could learn anatomy in person, said Chloe Connelly, M1. The learning experience we receive is unmatched by anything else.

M1 Michael Nazmifar said he was really grateful to the donors, too.

I remember our first day in the anatomy lab, he said. We were excited and nervous, but we wanted to learn, and I cant imagine a better way to study and learn anatomy than from the donors.

Esmail, who also served as one of the planning committee members for the memorial, said she wanted to honor the donors and their selfless donations.

The memorial was better than I ever could have imagined, she said. I hope people remember this dayand how much the donors helped us learn.

For more information, contact Andrew Dietderich, marketing writer, OUWB, at adietderich@oakland.edu.

To request an interview, visit the OUWB Communications & Marketingwebpage.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Two OUWB Class of 2024 members early match in ‘incredibly competitive’ specialty – News at OU

Two members of the OUWB Class of 2024 successfully matched Thursday in the highly competitive specialty of urology joining 25 alumni from the school to have done so since 2015.

Prasun Sharma matched at University of Pennsylvania and Moe Hijazi at University of Illinois.

They were among the 500 medical trainees competing for 394 positions in 148 urology residency training programs nationwide, according to the Society of Academic Urologists (SAU) and the American Urological Association (AUA). When the matching algorithm was processed, 77% of trainees were matched to a position in a program.

Early matches apply to specialties not affiliated with the National Resident Matching Program (NRMP), which annually holds its Match Day the third Friday in March (on March 15 this year). Military and ophthalmology programs also have early matches.

The two future urologists from the Class of 2024 join 25 OUWB alumni who have matched in the specialty since 2015 and helped establish OUWB as a top feeder school in the field.

OUWBs success in urology is what attracted me to it, said Sharma.

I looked at how the school consistently has students matching in urology. The students have to do their part, of course, but without department support for research, mentorship, and connectionsits difficult to mirror that type of success year after year.

Sharma said successfully matching and joining the OUWB alumni to have matched before him feels really good.

Its been incredibly competitive in the last three or four years in urologybut we have a fantastic staff here and I definitely put in the work, and it ended up working out pretty well, he said.

Peters

Kenneth Peters, M.D., chair, Department of Urology, called it an incredibly competitive year for the urology match.

I am very proud of the OUWB students that matched in urology, he said. This is a great accomplishment.

The Department of Urology continues to mentor many OUWB students interested in urology, and we provide them excellent research opportunities that gives them a competitive advantage as urology candidates, he added.

Chris Jaeger, M.D., OUWB 15, instructor, Department of Urology, and Sharmas faculty advisor, called OUWBs continued success in matching future urologists truly amazing.

I believe the success stems from the perfect fusion of passionate students, a strong medical school curriculum, and an extraordinary department of Urology at the Corewell Health William Beaumont University Hospital in Royal Oak led (by Peters), said Jaeger.

Dr. Peters has helped build the department into a national leader in clinical medicine and research that is revered by other leading institutions across the country, he added.

For Sharma, another big factor in his success was knowing early on that he wanted to specialize in urology.

Originally from Nepal, Sharma earned a bachelors degree in web design and development from Brigham Young University. Before starting at OUWB in 2020, Sharma served four years in the U.S. Army, where he was a medic. It was during his experiences with the military that he realized he could combine his background in information technology with his interest in medicine to specialize in a field like urology.

The very first (urology) case I saw was a laser breaking up a stone and my mind was blown, he said. Coming from a tech background, I absolutely fell in love with the field.

He hit the ground running and between M1 and M2 years was awarded a prestigious fellowship funded through the American Urological Association. He spent the summer as part of a research team at Corewell Health William Beaumont University Hospital in Royal Oak.

Post-fellowship, Sharma continued doing research, working alongside mentors like Michael B. Chancellor, M.D., professor, Department of Urology, at the Beaumont Research Institute.

Sharma, a 2023 Gold Humanism Honor Society inductee, said he also became involved in clinical learning early on, working closely with mentors like Brian Odom, M.D., OUWB 17, and Jaeger.

Mentorship is fundamental to medicine but also represents an important component in advancing specialty care like urology, said Jaeger. Dedicated mentorship is how I was able to match into urology and I feel an obligation to uphold this tradition at OUWB and Corewell Health for all medical students interested in urology.

Sharma, who is set to get married in May, said one of the first things he did in learning he matched was email and text those so critical to his success.

I told them that I could not thank them enough, he said. I also encouraged them to continue helping future students like me because we have a great pipeline for urology, and I hope that continues.

Thats exactly what Jaeger said OUWBs Department of Urology plans to do.

The faculty are so proud of the urology legacy at OUWB, and we hope to continue inspiring future OUWB medical students to pursue this field, he said.

For more information, contact Andrew Dietderich, marketing writer, OUWB, at adietderich@oakland.edu.

To request an interview, visit the OUWB Communications & Marketingwebpage.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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UW School of Medicine and Public Health dean to step down – Channel3000.com – WISC-TV3

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UW School of Medicine and Public Health dean to step down - Channel3000.com - WISC-TV3

Handley Notables: Dr. David W. Powers, Class of 1975 – The Winchester Star

David Powers, valedictorian of the Class of 1975, was a Star Leadership Award winner and voted Most Likely to Succeed by his class. He was a member of Phi Beta Kappa at Randolph-Macon College and Alpha Omega Alpha Medical School Honor Society at the Medical College of Virginia.

David completed his internship and residency in Emergency Medicine at the Hershey Medical Center in 1986. He returned to Winchester and became the first residency trained and board certified Emergency Medicine physician at the Winchester Memorial Hospital. When he became medical director of the Emergency Room, he set the hiring standard that all ER physicians would be board certified. He was dedicated to providing quality healthcare in a compassionate manner in Winchester for 35 years.

He was one of the first physician volunteers at the Free Medical Clinic and served on its endowment committee. He staffed the Winchester Medical Centers Mobile Care Unit for events such as the Shenandoah Apple Blossom Festival and the Battle of Cedar Creek Reenactment. He was the advisor for the Medical Explorers at Winchester Medical Center where high school students were introduced to possible medical careers.

David provided free physicals for scouts attending camps and high adventure activities. The Shenandoah Area Council Boy Scouts of America awarded him the Silver Beaver Award and the Distinguished Eagle Scout Award for his volunteerism. David was able to share his love of local history with everyone, especially young people. He served on the first Tourism Board for the Winchester and Frederick County area and on the board of the Winchester-Frederick County Historical Society. He was a founding member of the Stone House Foundation at the Newtown History Center and of the Shenandoah Valley Battlefield Foundation. He was the vice-president of the Kernstown Battlefield Association from its founding until 2019. David co-chaired the renovation of George Washingtons Office Museum in 1999. He helped organize exhibits for the Historical Society and Kurtz Cultural Center of Preservation of Historic Winchester.

Powers will be remembered not only for his life long commitment to the health of the people in the community but also for his support of youth and his love of local history.

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Nike and Giannis Antetokounmpo Unleash Exciting New Colorways for Immortality Line – BNN Breaking

Nike and Giannis Antetokounmpo Unleash Exciting New Colorways for Immortality Line

As the NBA All-Star Weekend draws near, the spotlight once again lands on basketball icon Giannis Antetokounmpo and his ongoing collaboration with sportswear titan, Nike. This time around, the partnership brings a fresh spin to Gianniss Immortality line, an affordable range of basketball shoes renowned for their style and performance.

The latest addition to the Immortality collection is set to captivate fans with its vibrant color palette. The shoe features a yellow mesh as the primary material, extending into the midsole. This bright hue is tastefully contrasted by a green/yellow camo pattern on the outsole. The unconventional colorway, while not a direct replica of the Milwaukee Bucks official colors, offers a playful nod to Gianniss home team with its use of brighter tones.

On top of the colorways bold statement, the shoe carries the unmistakable mark of both Nike and Giannis. The iconic Nike Swoosh is prominently featured on the body of the shoe, bearing a contrasting green accent. Likewise, the athletes branding is easily spotted on the tongue and heel pull tab, reinforcing the players personal touch on the design.

Beyond the yellow and green variant, another highlight from the collection is the Red/White version of the Giannis Immortality 3. This special edition colorway pays tribute to Gianniss brother, Thanasis Antetokounmpo, a testament to the athletes deep-rooted family values.

As fans eagerly await the release of these new designs, the anticipation only adds to the excitement of the upcoming All-Star Weekend. With Giannis at the helm, this Immortality line continues to push boundaries, offering stylish and affordable options for basketball enthusiasts worldwide.

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Nike and Giannis Antetokounmpo Unleash Exciting New Colorways for Immortality Line - BNN Breaking

Caitlin Clark Keeps Gliding Towards Immortality – Defector

When a player scores 35 points in a blowout victory over a conference opponent, and in the process claims the all-time Big 10 scoring record and moves into second place on the NCAA all-time scoring list, you don't expect to be talking about how broken her jumper looked.

But it's true: Caitlin Clark's jumper was beat last night. She shot 3-of-12 from three-point range, and all of her other points were scored either at the rim or the free-throw line. She went through an entire game with her signature long-range shots repeatedly finding back rim and air, and still scored 35 points, and still shot 50 percent from the field, and still beat Northwestern by 36. That set of facts speaks to how good, and how complete, of a player Clark has become in her final season as a collegiate athlete, which will end with her sitting alone at the top of all-time scoring list.

There was maybe a time, earlier in Clark's career, when she could have been described as a step-back merchant. But that hasn't been true for a long time, and the performance she put together on Wednesday night was a perfect example of her ability to control a game through any method she desires. Whereas lesser players may have been helpless to stop a dreadful shooting night from pulling them into the muck, Clark took it as a sign to try something else. It was kind of funny to watch: Every time Clark put up a three that missed badly, you could see a look that said Fuck this briefly fall across her face, and then she would spend the next few possessions driving menacingly to the rim, where she would either score, get fouled, or kick out to an open teammate.

The highlight reels that populate TikTok and Instagram would have you believe that the scariest thing a defender can be confronted with in college basketball is Caitlin Clark stepping back and getting ready to launch from near the logo, but the actual stuff of nightmares is Clark grabbing a defensive rebound, seeing a pathway to the opposite rim, and deciding to travel it as quickly and forcefully as possible. It's a part of her game that might get overlooked sometimesand with good reason, those step-backs from the logo are gorgeousbut Clark is a demon in transition and semi-transition. Nobody on Northwestern was quick enough to stay in front of her or strong enough to challenge her in the paint without fouling, and so Clark spent most of her Wednesday night bludgeoning them at the rim, where she scored 16 of her points and got herself to the line 10 times.

Clark is now just 103 points away from the No. 1 spot on the all-time scoring list, which has been occupied by Kelsey Plum since 2017. She has eight games left to play, and is averaging 32 points per game, which means that her claiming of the record is a foregone conclusion barring injury. The scoring record will just be another addition to the absurd constellation of numbers that have come to define Clark's career at Iowa. There's the 27-7-7 she's averaged over the course of her career, the 50 30-point games, the 11 40-point games, and the 15 triple-doubles. All of that adds up not to describe just one of the greatest college basketball players we've ever seen, but a player who has achieved a virtuosity in her sport. That's what was on display on Wednesday night: It wasn't grit or determination or will that allowed Clark to score 35 despite not having the use of her jumper; it was mastery.

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USM Chemistry (Biochemistry Emphasis) Degree Earns ASBMB Reaccreditation – The University of Southern Mississippi

Wed, 01/31/2024 - 01:21pm | By: Ivonne Kawas

The University of Southern Mississippis (USM) B.S. degree in Chemistry (Biochemistry emphasis) has earned reaccreditation by the leading agency in the field of life sciences the American Society for Biochemistry and Molecular Biology (ASBMB).

This accreditation was obtained for the first time in 2017. Obtaining ASBMB accreditation, a national outcomes-based evaluation, ensures programs in the field meet the highest standards of academic excellence. USMs chemistry degree program is housed in the School of Mathematics and Natural Sciences (MANS),

Accreditation by ASBMB is a testament to the quality and content of our biochemistry curriculum, as well as to the knowledge and skills learned by our students as they begin to seek careers or further their studies at the graduate or professional levels, said Dr. Chris Winstead, dean of the College of Arts and Sciences. I appreciate the effort of the faculty in seeking this accreditation. This shows their dedication to providing the best preparation possible for our Southern Miss students, an education that is well-aligned with national standards and prepares them for their next steps.

Dr. Vijay Rangachari, professor of chemistry and biochemistry, emphasizes one of the direct accreditation benefits for students.

ASBMB accreditation inherently enhances the value of the students degree, allowing them to include on their resume that they graduated from an ASBMB-accredited program. Furthermore, upon degree completion, they can demonstrate competitiveness on a national scale by obtaining ASBMB certification.

Dr. Rangachari also highlights one of the strengths of the program, integral to both student success and ASBMB accreditation: the hands-on research opportunities provided in the laboratory.

To meet accreditation requirements, the curricula must include over 400 hours of hands-on laboratory experience. Therefore, students get an advantage in advancing their careers.

Students like Landon Lee, a native of Hattiesburg, Miss. who is pursuing the biochemistry emphasis, actively participate in cutting-edge research projects in the lab, alongside graduate students and faculty mentors.

Joining a research lab has significantly enriched my educational experience, as Ive been able to acquire skills related to academic research, project management, and creative thinking, said Lee. With the support and guidance from both the graduate students in my lab and Dr. Rangachari, my faculty mentor, it has become more than just a platform for applying classroom concepts; it has provided me a community that fosters my personal and academic development.

After completing his bachelors degree, Lee plans to further his studies: As I complete my degree, I intend to pursue a Ph.D. in neuroscience. My coursework has undoubtedly laid a strong foundation in physics, chemistry, and mathematics, enabling me to demonstrate key strengths as I strive toward this goal.

Dr. Theofanis Kitsopoulos, director in the School of MANS, reflects on the programs successful and highly valued alumni base, as it opens doors to diverse industries.

Our curriculum is carefully crafted to equip students not only with a strong theoretical foundation but also with practical skills highly valued in the job market, said Dr. Kitsopoulos. Several of our alumni choose to pursue advanced degrees in prestigious graduate programs in medical, dental, pharmaceutical, and other professional schools. They go on to succeed in diverse industries such as research and development, healthcare, environmental consulting, forensic science, and entrepreneurship. Some thrive as quality control and analytical chemists, while others pursue fulfilling paths as middle and high school science and chemistry teachers.

Learn more about the B.S. degree in Chemistry (Biochemistry emphasis).

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USM Chemistry (Biochemistry Emphasis) Degree Earns ASBMB Reaccreditation - The University of Southern Mississippi

AI generates proteins with exceptional binding strength – ASBMB Today

A new studyin Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University of Washington School of Medicine used software to create protein molecules that bind with exceptionally high affinity and specificity to a variety of challenging biomarkers, including human hormones. Notably, the scientists achieved the highest interaction strength ever reported between a computer-generated biomolecule and its target.

Ian Haydon, UW Medicine Institute for Protein Design

Susana Vasquez-Torres in a UW Medicine Institute for Protein Design laboratory, where she is working to develop new proteins with high-binding affinity and specificity to a variety of challenging biomarkers.

Senior author David Baker, professor of biochemistry at UW Medicine, Howard Hughes Medical Institute investigator, and recipient of the 2023 Frontiers of Knowledge Award in Biology and Biomedicine, emphasized the potential impact: "The ability to generate novel proteins with such high binding affinity and specificity opens up a world of possibilities, from new disease treatments to advanced diagnostics."

Ian Haydon/UW Medicine Institute for Protein Design

A new protein designed using deep-learning methods. In this case, RFdiffusion generates a binding protein.

The team, led by Baker Lab members Susana Vazquez-Torres, Preetham Venkatesh, and Phil Leung, set out to create proteins that could bind to glucagon, neuropeptide Y, parathyroid hormone, and other helical peptide targets. Such molecules, crucial in biological systems, are especially difficult for drugs and diagnostic tools to recognize because they often lack stable molecular structures. Antibodies can be used to detect some of these medically relevant targets but are often costly to produce and have limited shelf lives.

"There are many diseases that are difficult to treat today simply because it is so challenging to detect certain molecules in the body. As tools for diagnosis, designed proteins may offer a more cost-effective alternative to antibodies," explained Venkatesh.

The study introduces a novel protein design approach that uses advanced deep-learning methods. The researchers present a new way of using RFdiffusion, a generative model for creating new protein shapes, in conjunction with the sequence-design tool ProteinMPNN. Developed in the Baker Lab, these programs allow scientists to create functional proteins more efficiently than ever before. By combining these tools in new ways, the team generated binding proteins by using limited target information, such as a peptide's amino acid sequence alone. The broad implications of this "build to fit" approach suggest a new era in biotechnology in which AI-generated proteins can be used to detect complex molecules relevant to human health and the environment.

Ian Haydon/UW Medicine Institute for Protein Design

An AI-designed protein in detail from the UW Medicine Institute for Protein Design.

"We're witnessing an exciting era in protein design, where advanced artificial intelligence tools, like the ones featured in our study, are accelerating the improvement of protein activity. This breakthrough is set to redefine the landscape of biotechnology," noted Vazquez-Torres.

In collaboration with the Joseph Rogers Lab at the University of Copenhagen and the Andrew Hoofnagle Lab at UW Medicine, the team conducted laboratory tests to validate their biodesign methods. Mass spectrometry was used to detect designed proteins that bind to low-concentration peptides in human serum, thereby demonstrating the potential for sensitive and accurate disease diagnostics. Additionally, the proteins were found to retain their target binding abilities despite harsh conditions including high heat, a crucial attribute for real-world application. Further showcasing the method's potential, the researchers integrated a high-affinity parathyroid hormone binder into a biosensor system and achieved a 21-fold increase in bioluminescence signal in samples that contained the target hormone. This integration into a diagnostic device highlights the immediate practical applications of AI-generated proteins.

The study, which illustrates the confluence of biotechnology and artificial intelligence and sets a new precedent in both fields, appears in Nature with the title De novo design of high-affinity binders of bioactive helical peptides.

(This article was produced by the University of Washington School of Medicine/UW Medicine.)

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Will future colonists on the moon and Mars develop new accents? – Livescience.com

In the not-too-distant future, humans will begin to spread out into the solar system and not just for fleeting visits. The ultimate goal of space exploration (apart from finding aliens) is to set up human colonies on other worlds to learn more about our cosmic neighborhood and search for new resources that could help us thrive on Earth.

The first human space colonies will likely take root on the moon and could emerge within the next few decades. But the bigger, long-term target is to put a colony on Mars, which will become a more realistic goal once we've established a permanent presence on the moon.

The idea of human groups living away from our planet opens up a litany of questions about future colonists for experts to solve, such as how they will grow food or access water and how will they adapt to living with less gravity.

However, one query has long been overlooked: What might future space colonists sound like? Or, more specifically, what kind of accents might they develop?

Human accents are a fascinating topic of research in themselves. Every person has at least some sort of accent, regardless of whether they realize it, and all of these accents can be traced to specific times, places, languages or groups of people here on Earth. But with the dawn of space colonies on the horizon, the way future interplanetary settlers will pronounce their words is uncharted territory.

Related: Which animals will be the first to live on the moon and Mars?

"New accents emerge by imitation," Jonathan Harrington, director of the Institute for Phonetics and Speech Processing at the Ludwig-Maximilians University of Munich in Germany, told Live Science. "We remember the sounds and words of a conversation, and these can have a small influence on the future way that we speak."

These changes are subconscious and occur only when we interact with people who have different accents from us over long periods, Harrington said. This is why people who have lived in a new country or region for long periods develop subtle changes to their accents without realizing it.

But when people with different accents become isolated from the rest of the world, the entire group will start to mimic one another, creating a brand-new blend of the available accents, Harrington said. This can start to happen very quickly, especially in small groups, he added.

In 2019, Harrington led a study that analyzed the phonetic changes of 11 researchers who spent a winter isolated in a laboratory in Antarctica. The group comprised eight people from England (five with Southern accents and three with Northern accents), one from the U.S. Northwest, one from Germany and one from Iceland. Throughout the experiment, the researchers noticed that each individual displayed phonetic changes and that the group collectively started pronouncing specific sounds differently and used different parts of their mouths to make those sounds. These were the first steps of a new accent forming.

"Exactly the same thing should happen in any environment in which individuals are isolated together over a prolonged period, whether this is in Antarctica or in space," Harrington said. "In fact, accent change should be even greater in space because contact with the home community is even more difficult."

On Mars or the moon, colonists could start to develop subconscious-yet-audible changes to their accents within a few months especially on Mars, where conversing with people on Earth is even more challenging due to the roughly 20-minute delay it takes for messages to travel between the two planets, Harrington said.

However, for unique, long-lasting accents to emerge, the colony likely would need to be big enough for colonists to reproduce, so that the accent could be passed on to future generations.

Related: Which planet is closest to Earth? (Hint: There's more than 1 right answer.)

If new colony members were added to a colony in the early stages of habitation, they could shift the trajectory of that group's accent. However, once an accent were fully established, new colonists would likely have a minor impact on how that accent evolved and would slowly change their accents to match that of the rest of the colony.

Any new accents that developed in space colonies would likely be shaped by the most abundant accent within the group, Harrington said. A good example of this is the Australian accent, which has lots of similarities to London's "Cockney" accent because most of the original settlers had that accent, he added.

If the initial accents were evenly split, then the new accents would be a mix of them all, rather than resembling one particular accent. As a result, unless future colonies on Mars and the moon are made up of groups with an identical mix of accents, they would likely develop different accents, Harrington said. The different environmental factors on the moon and Mars would likely not impact either accent in a major way, he added.

Without knowing the accents of the astronauts that will make up future Martian and lunar colonies, it is hard to predict what these accents might sound like. However, as soon as the colonists are selected, it could be possible to predict how the accents will evolve.

During the 2019 study in Antarctica, the study team used a computer learning program to predict how the participants' accents might change during the study. To their surprise, the team found the vocal changes they observed matched up very well with what the program predicted.

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Will future colonists on the moon and Mars develop new accents? - Livescience.com

Things to Do This Weekend in The Palm Beaches – The Palm Beaches

Events for Friday, February 2 Lake Worth Beach Bonfire, Lake Worth Beach

Pack up your smores kits and enjoy roasting marshmallows around a mini bonfire in Lake Worth Beach. This is a family-friendly event!

Featured artists: The Leafy Greens.

Time: 6 pm 10 pm.

Location: Lake Worth Beach and Casino Complex, 10 South Ocean Blvd, Lake Worth Beach, FL 33460.

Each Friday night from 5:00 pm to 10:00 pm, the Norton Museum of Art in West Palm Beach organizes Art After Darka fun mix of art and entertainment featuring a docent-led tour, an open studio, live music, and more! This Friday, join a tour that will highlight African American artists whose work is on view.

Clickhere for more details.

Location: Norton Museum of Art, 1450 S. Dixie Highway, West Palm Beach, FL 33401.

Get ready for The Art of Laughter: A Hysterical Stand-Up Comedy Series at Arts Garage!

Come see some of the best touring comedians from South Florida and beyond, the first Friday of every month.

Time: 8 pm 10 pm

Cost: $35

Get tickets.

Location: Arts Garage, 94 NE 2nd Ave., Delray Beach, FL 33444.

Learn the dance of passion from professional dance instructors. If you are looking to socialize, get your dance on, and make new friends, then join us. Monthly dance workshops are FREE to attend from 6:30 8 p.m. Walk-up registration is also welcomed starting at 5:30 p.m. Click Here to view instructors.

Register here.

Location: City Hall Courtyard, 407 Clematis Street, West Palm Beach, FL 33401.

Mark your calendars to celebrate Manatee Lagoons 8th anniversary at ManateeFest 2024! This FREE, family-friendly event is an annual celebration where you can explore the wonders of manatees, the Lake Worth Lagoon, and environmental conservation.

Experience a day packed with activities for everyone, including face painting, live music, photo opportunities with Mia the Manatee, a KidsFunZone, food vendors, arts and crafts vendors, eco-conscious exhibitors, and more!

Manatee Lagoonoffers a dedicated area for viewing manatees up close and a robust year-round program and event schedule.

Time: 9 am 4 pm.

Location: Manatee Lagoon, 6000 North Flagler Drive, West Palm Beach, FL 33407.

Visit The Square for the third annual Black History Month Kickoff Eventpresented by Rohis Readery. Enjoy a series of events celebrating African Diasporic peoples multifaceted history and culture. The Spirit of this event is to uplift a narrative that will include live music, vendors, classes for children, and workshops for adults.

Location: The Square, 700 South Rosemary AvenueWest Palm Beach,FL33401.

Roll out your mats with the community as Natalie Addison guides you through an all-levels Vinyasa class. Start your weekend off right, enjoy a fresh playlist, move your body and set intentions for the day. All levels, bodies and people are welcome. The class takes place on Rosemary Ave in front of True Food Kitchen.

Bring: A Yoga mat, towel and water.

Time: 10 am

$10 suggested donation. Donations can be made on site via Venmo or cash.

Advanced registration is not required.

Location: The Square, 700 South Rosemary Avenue West Palm Beach, FL 33401.

Visit the West Palm Beach GreenMarket and shop over 125 vendors selling various products, including fresh fruits and vegetables, coffees and teas, flowers and plants, homemade specialty items, desserts, and treats, and so much more.

Time: 9 am 1 pm

Location: Great Lawn, 100 N. Clematis Street, West Palm Beach, FL 33401.

The Delray Green Market is a Saturday morning destination. At the Green Market youll find more than 50+ vendors featuring Palm Beach County farm-to-fork produce, just picked citrus and juice, farm fresh eggs, raw milk, and butter, 100% grass-fed and finished (antibiotic and hormone free). Florida beef, poultry, pork and lamb, fragrant artisan baked goods, plenty of gluten-free, vegan and sugar-free products, fresh cut flowers, plants and other unique gourmet fare along with live musical entertainment each week.

Time: 9:00 am 2:00 pm

Location: Old School Square, 96 N.E. 2nd Avenue, Delray Beach, FL 33444.

Every Saturday from 10 am to 1 pm, shop 30 incredible local vendors at a real farmers market on a real farm! The market offers not only the best produce that you expect from Swank Farm, but also bakers, growers, gardeners, and sellers of the best Farm Market products that you can possibly want.

Location: Swank Farm, 14311 North Road, Loxahatchee Groves, FL 33470.

Celebrate the Lunar New Year by exploring artworks in the Chinese Collection and become inspired by the symbolic meanings behind the creatures depicted in these artworks. In the studio, explore calligraphy, stamps, sculptures, and paintings, using similar ancient techniques. Children ages 5 12, and their accompanying grown-ups, participate in a thematic tour, followed by a related art workshop. Every Saturday is a new experience!

Space is limited: online registration required.

Cost: Free admission for children and adults.

Time: 11 am 1 pm

Location: Norton Museum of Art, 1450 S. Dixie Highway, West Palm Beach, FL 33401.

American Tune: Simon, Croce & Taylor takes you on a magical trip back to the 1970s to experience the timeless music and prolific songwriting of Paul Simon, Jim Croce and James Taylor. Relive the intimate storytelling, intricate chord changes and breathtaking melodies of these gifted artists, their work building on and transcending the more traditional folk-influenced acoustic music of the previous decade.

Time: 8 pm 10 pm

Cost: $45 $50

Get tickets.

Location: Arts Garage, 94 NE 2nd Ave., Delray Beach, FL 33444.

Break a sweat with fellow runners in the community during this run club led by lululemon ambassador Alex Celis. Meet in front of lululemonto mingle, stretch and warm up before setting off on a 2-mile loop around Downtown West Palm Beach, ending back atThe Saltyfor a cool down and sweet treat.

Time:Warm-up at 8:45AM; run begins in at 9AM

Register Here to Run

Location: The Square, 700 South Rosemary Avenue West Palm Beach, FL 33401.

Shop at the market at Harbourside Place every Sunday, from 10 am 4 pm! Stroll along the Intracoastal while shopping local artisan and handmade goods!

Time: 10:00 am 4:00 pm

Location: Harbourside Place, 200 N US Highway One, Jupiter, FL 33477.

Enjoy a multi-course dinner at Swank Farm. Wear something in the Carnival colors (purple, green, gold) bring your favorite Mask and lets get into the Mardi Gras Spirit.

Benefiting: Connections Education Center of the Palm Beaches.

Clickhereto see the participating chefs and to get tickets.

Location: Swank Farm, 14311 North Rd, Loxahatchee, FL 33470.

Get onboard The Brunch Club Experience presented by The Palm Beaches for vibes, bites, and delights. Your Brunch experience lets you enjoy a one-way PREMIUM ride on a themed coach with complimentary snacks on your ride up, and plenty of bubbly from exclusive partners like MOET, and Ruffino Prosecco Rose for you and your friends. Plus, Guests get free entry to the Historical Society of Palm Beach County with their Brightline ticket.

Leave room for seconds. Brunch Club riders can enjoy a complimentary drink, appetizers and other perks from these participating restaurants at The Square:

Brunch Club trains run three times a day on February 4 and February 11 from MiamiCentral Station to West Palm Beach Station at 9:45 am, 10:50 am, and 11:45 am. Guests are responsible for their return trip.

BOOK NOW

Janes quartet program, her most frequent offering, is as varied as her twelve studio albums. Featuring some of the worlds finest musicians, her band expertly accompanies her as she interprets iconic songs from the Great American Songbook, famed Brazilian composers, and the singer-songwriters of the twentieth century.

Time: 7 pm 8:30 pm

Cost: $55 $60

Get tickets.

Location: Arts Garage, 94 NE 2nd Ave., Delray Beach, FL 33444.

When: January 30 February 3, 2024

Now celebrating its 29thanniversary, FOTOfusion is a popular cultural festival where creativity and technology fuse. The festival attracts thousands of professional and hobbyist photographers to West Palm Beach for a series of workshops, lectures, panel discussions, multimedia presentations, portfolio reviews, hands-on computer classes, demonstrations, and photo shoots taught by world renowned photographers, digital imaging artists and picture editors all of whom donate their time and expertise to educate, mentor and encourage creativity among participants of all levels and ages.

The 29th annual FOTOfusion will celebrate distinguished photojournalist David Burnett, the recipient of the prestigious FOTOmentor Award 2024.

To register or for more information, clickhere.

Location: Palm Beach Photographic Centre, Clematis Street, West Palm Beach, FL 33401.

When:

Get ready to hold your breath and unleash your appetite because the Best Stinkin Party in South Florida is back, and its more aromatic and exciting than ever!

Mark your calendars for February 3rd and 4th as this internationally acclaimed event returns to Wellington, ready to tantalize your taste buds and thrill your senses. From the moment you step foot into this culinary wonderland, youll be swept away by the vibrant atmosphere that surrounds you.

The aroma of garlic-infused delicacies will waft through the air, leading you to the renowned Gourmet Alley. Brace yourself for an incredible selection of over 100 garlicky menu items that will leave you craving more. From classic favorites to bold and innovative creations, prepare to embark on a flavorful journey like no other.

The Best Stinkin Party is more than just food! Its a full-blown entertainment extravaganza! Prepare to be mesmerized by the electrifying performances of nationally acclaimed musical acts that will take the stage.Learn more.

Location: 12100 Forest Hill Blvd., Wellington, FL 33414.

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Things to Do This Weekend in The Palm Beaches - The Palm Beaches

Update: High bacteria count notification canceled for Onekahakaha Beach swimming area in Hilo – Big Island Now

January 31, 2024, 3:15 PM HST * Updated January 31, 4:15 PM

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Update at 4:15 p.m. Jan. 31: The Hawaii Department of Health has canceled the high bacteria notification for the Onekahakaha Beach swimming area in Hilo. Water sample retesting results show that enterococci levels no longer exceed the threshold level.

Original post: The Hawaii Department of Health is notifying the public about a high bacteria count at a Big Island beach.

The department is retesting waters at the Onekahakaha Beach swimming area in Hilo after bacteria levels of 2,005 per 100 mL were detected during routine beach monitoring.

The Health Department is uncertain about the representativeness of the first sample, as the beach has historically met the acceptable threshold level and there is no known source of fecal contamination.

Therefore, another sample was collected and the Health Department is retesting the site.

The department will update the notification based on the results of the retesting.

For more information, click here and here.

Continued here:

Update: High bacteria count notification canceled for Onekahakaha Beach swimming area in Hilo - Big Island Now