Resveratrol, Compound In Red Wine, Could Be Beneficial After All

By Tia Ghose, Staff Writer Published: 10/02/2013 02:53 PM EDT on LiveScience

Resveratrol, a chemical found in red wine that is often touted for its anti-aging benefits, is chemically active in cells, which has been doubted, according to new research.

Despite earlier research on resveratrol's activity in the human body that cast doubt on its potential to benefit people's health, the new findings show the compound can be converted in the body into its active form, which cells can use.

That conclusion, published today (Oct. 2) in the journal Science Translational Medicine, bolsters the notion that the compound could have health benefits. [4 Foods That Are Good Sources of Resveratrol]

Red wine compound

Resveratrol is found in the skin of red grapes, dark chocolate and other foods, and many believe it has potential health benefits. Some research has found that the compound can activate a chemical pathway in cells linked to slower aging, and other studies have tied it to cardiovascular benefits and anti-cancer effects.

However, studies of the compound in people and animals have yielded mixed results. One found that resveratrol extends the life span of fat mice, but has no benefit for their lean counterparts. And a 2012 study in Cell Metabolism found that healthy people taking resveratrol supplements gained no benefit from them.

In addition, researchers weren't sure how resveratrol could be active biologically.

"One of the major problems is that when you eat it, it's very, very quickly converted by the body into sulfate and gluconoride metabolites," said study co-author Karen Brown, a cancer researcher at the University of Leicester in England.

Some scientists doubted that resveratrol sulfate, the modified form of the chemical, was active in the body.

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Resveratrol, Compound In Red Wine, Could Be Beneficial After All

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