New Study Shows Gut Bacteria Produces Secret, Anti-Aging Molecules – Wall Street Pit

When we were young, we viewed our parents like they were the most powerful human beings in the world.

They exuded health, strength, such admirable quickness of mind in answering our endless questions, and the might to balance career and family.

How did they do it?

That used to puzzle us, as we kept getting delighted in the thought that we had extraordinary human beings playing the role of mom and dad.

At first, we begin to blame our society or the world in general for the wealth of new and challenging problems that people are forced to face everyday. Then, gradually we begin to realize that life for our parents after all, wasnt as easy as we had perceived it when we were young.

As the years go by, with us having our own families, and going through the same stressful phases that our parents had gone through, its right then we start to realize that the weaknesses and diseases that came to plague our mom and dad would also be our unavoidable fate.

Were all destined to grow old.

Today, the global anti-aging industry is worth more than $140 billion and has been predicted to rise to nearly $217 billion by 2021.

The worlds leading companies, including Google, are involved in anti-aging research and treatment of age-related diseases.

From Senescence Info, heres a list of some of these companies and their anti-aging endeavors:

Now, whats new?

The discovery, this time, is not about yeast, telomeres, stem cells, or genes.

Its about molecules. To be exact, a molecule type thats produced by commensal bacteria and one which has the ability to extend healthspan.

Commensal bacteria are living organisms that derive their food from other living organisms. But, unlike parasites, they do not harm or hurt their host. This type of bacteria, also known as commensal microflora, usually inhabit the gut, respiratory tract, and skin.

In humans, the number of commensal bacteria that colonize our skin and mucosal surfaces is greater than the number of cells forming our body.

However, this molecule called indole, which was discovered by researchers at the Emory University School of Medicine, came from commensal bacteria that the team studied in the gut of worms (Caenorhabditis elegans), mice, and fruit flies to determine its anti-aging properties.

According to the authors, and as published on PNAS, the small molecules [which are shown to be] produced by the microbiota and related to indole extend healthspan in geriatric worms, flies, and mice, without attendant effects on lifespan. Indoles act via the aryl hydrocarbon receptor (AHR) and cause animals to retain a youthful gene expression profile. Indoles may represent a new class of therapeutics that improve the way we age as opposed to simply extending how long we live.

Indoles and AHR are also found in the human body. The former exists in humans and mammals in small quantities, produced from plant dietary sources and intestinal microbiota. Whats more fascinating about indole is that it can extend not only an organisms healthspan, but fecundity and reproductive span as well.

The study is statistically extremely robust, remarks Dario Valenzano of the Max Planck Institute for Biology of Ageing. The paper convincingly shows that the lack of indoles is detrimental to healthspan. What will be interesting is to see if the same effect holds good with wild-type animals treated [extraneously] with indoles.

Indeed, its a remarkable discovery. But, mankind appears to unfortunately, still have a long way to go in their quest for longer, healthier life.

As study author Daniel Kalman notes: It is a long road to go from the data we present to a drug. That takes careful development, testing, and safety and efficacy trials.

Despite the relatively long road ahead (I say relatively based on the fact that AI applications are on a seemingly rapid upward trajectory and anything is possible. We may have a breakthrough tomorrow or five years from, nobody knows for sure) the fact that new advancements in modern technology are finally offering up some real promising possibilities for ways to reverse aging as a process, is a breakthrough in anti-aging research and the right step toward a healthier, longer life and consequently, a brighter future for all of us.

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New Study Shows Gut Bacteria Produces Secret, Anti-Aging Molecules - Wall Street Pit

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