The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Because of its severe impact, multiple COVID-19 vaccines are being rapidly developed, approved and manufactured. Among them, mRNA vaccines are considered as ideal candidates with special advantages to meet this challenge. However, some serious adverse events have been reported after their application, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Although several fertility societies have announced that COVID-19 mRNA vaccines are unlikely to affect fertility, there is no denying that the current evidence is very limited, which is one of the reasons for vaccine hesitancy in the population, especially in pregnant women. Herein, we provide an in-depth discussion on the involvement of the male and female reproductive systems during SARS-CoV-2 infection or after vaccination. On one hand, despite the low risk of infection in the male reproductive system or fetus, COVID-19 could pose an enormous threat to human reproductive health. On the other hand, our review indicates that both men and women, especially pregnant women, have no fertility problems or increased adverse pregnancy outcomes after vaccination, and, in particular, the benefits of maternal antibodies transferred through the placenta outweigh any known or potential risks. Thus, in the case of the rapid spread of COVID-19, although further research is still required, especially a larger population-based longitudinal study, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection.

Keywords: ACE2; COVID-19; SARS-CoV-2; angiotensin-converting enzyme 2; coronavirus disease 2019; fertility; mRNA vaccine; pregnant women; reproductive system; severe acute respiratory syndrome coronavirus 2.

More:
Effects of COVID-19 and mRNA vaccines on human fertility

Abstract

BACKGROUND: Vaginal anatomy has been poorly studied. This study aimed to measure baseline dimensions of the undistended vagina of women of reproductive age. METHODS: We combined baseline information collected from five clinical trials using magnetic resonance imaging (MRI) to quantify distribution of a vaginal gel. Seventy-seven MRI scans were performed on 28 women before gel application to establish baseline vaginal measurements. Average dimensions were calculated for each woman and for the population. The influence of potential covariates (age, height, weight and parity) on these dimensions was assessed. RESULTS: MRI measurements are reproducible. The SD surrounding the mean at each anatomical site, and with summary measurements, was significantly smaller with each subject compared with the population. Mean vaginal length from cervix to introitus was 62.7 mm. Vaginal width was largest in the proximal vagina (32.5 mm), decreased as it passed through the pelvic diaphragm (27.8 mm) and smallest at the introitus (26.2 mm). Significant positive associations were parity with vaginal fornix length, age with pelvic flexure width and the height with width at the pelvic flexure. CONCLUSION: No one description characterized the shape of the human vagina. Although there is variation among women, variables such as parity, age and height are positively associated with differences in baseline dimensions.

In comparison with other female pelvic organs, the anatomy of the vagina has been relatively poorly studied. Our knowledge of female pelvic anatomy is based on old descriptions derived from the dissection of a small number of female cadavers. These studies depict the vagina as a straight hollow tube extending vertically upwards towards the sacral promontory (Grant, 1943; Eycleshymer and Schoemaker, 1983; Sultan et al., 1993). In the late 19th century, Hadra in Lesions of the vagina and pelvic floor, discussed the possibility of differences in anatomy for a living patient, also noting that the vaginal axis is different in the upper and lower vagina (defined as the sections of the vagina above and below the pelvic diaphragm) (Hadra, 1888).

New research on pelvic imaging has focused on paediatric, premenopausal and post-menopausal groups; or disease entities like utero-vaginal anomalies, prolapse, fistula or pelvic malignancies. As the focus of past research has been mainly curative, limited study has been conducted on the normal anatomical variations of the vagina of young, healthy and sexually active women (Hafez and Evans, 1978).

The literature, to date, describes the relaxed vagina as a fibro-muscular tube that exists as a collapsed potential space. The shape of the tube is not symmetrical or similar to any known geometric shape. Rather, the vaginal lumen is a potential space with walls that are easily distensible. The overall shape and stretching of the vaginal canal are constrained by the elasticity of the vaginal wall and its relationship to other pelvic organs. The cross section of the relaxed vagina at the level of the cervical os has been classically characterized as an H shape. More recent data suggest that the shape may instead resemble a W (Barnhart et al., 2004a).

Studies have utilized casts to visualize the vagina in three dimensions and to compare vaginal shape, dimensions and surface contact in various ethnic populations. The casts consisted of wax, rapidly solidifying dental impression paste, polyvinyl siloxane, etc. (Morgan, 1961; Richter, 1967; Pendergrass et al., 1996). These studies were limited by the abnormal distension of the vagina; however, they suggested differences among vaginal shapes and dimensions in African-American, Caucasian and Hispanic women (Richter, 1967; Pendergrass et al., 2000). These studies have also suggested a uniform size of all the different shapes of the vagina, and hence have supported the development of the one size fits all vaginal product, formulation or microbicide (Pendergrass et al., 2003).

The goal of this project was to define baseline, nondistended dimensions of the vagina of women of reproductive age using noninvasive imaging. Magnetic resonance imaging (MRI) is the optimal imaging modality for female pelvic organs because the images have excellent spatial resolution and inherently high soft tissue contrast (McCarthy and Vaqueno, 1986; Aronson et al., 1990; Barnhart et al., 2001, 2004b). A secondary goal was to explore the importance of the potential covariates to the dimensions of the human vagina including the impact of age, height, weight, gravity and parity. This information may help researchers optimize vaginal products and drug delivery.

This study was reviewed and approved by the Institutional Review Board of the University of Pennsylvania (Protocol CSA-03-333). This study is an analysis of the baseline MRI at entry in five clinical trials evaluating the distribution of a vaginal product. Data from the following five experimental protocols were utilized for this study:

spread of 3 ml of KY jelly and Replens with and without ambulation (unpublished data);

comparison of two volumes of cellulose sulphate (2.5 ml versus 3.5 ml) with and without ambulation (Barnhart et al., 2005a);

effect of volume (3.0 ml versus 5.0 ml) and ambulation on gel spread, and a substudy on the effect of simulated intercourse on the spread of gel in the vagina (Barnhart et al., 2004b);

study of spread of Savvy gel in the vagina (Barnhart et al., 2005b) and

vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert (Barnhart et al., 2004c).

As part of these trials, an MRI was performed prior to use of any study product to serve as a baseline for comparison after gel insertion. The trials then quantified the spread of the gel depending on time from application, ambulation of the volunteer, sexual activity of the subject, gel volume and formulation. Other data that quantified the spread of the gel were not included. The analysis for this study is confined to the MRI examinations of these volunteers before using the experimental product to assess the baseline vaginal dimensions of women of reproductive age.

All subjects were aged 1845 years, not at risk for pregnancy (using reliable contraception or abstinence), menstruated regularly and had a normal Papanicolaou smear.

MRI examinations were performed on a dedicated research GE 1.5 Tesla Signa scanner with the assistance of a phased array surface coil centred on the pelvis, to allow small fields of view and to increase signal to noise ratio. We used Sun Ultra workstation, GE Advantage Windows 3.1 software, electronic callipers and digitally stored images to make measurements. The specific details of MR techniques have been published previously (Barnhart et al., 2001, 2004b, 2005a; Pretorius et al., 2002).

The linear length of the vagina was the measurement in the sagittal plane from the external cervical os to the introitus (approximately at the level of the hymeneal ring) (Figure 1). Measurements were also taken at the following anatomic structures in millimetres: (i) two measurements of the posterior vaginal fornixwidth and length in the anterior posterior (AP) and sagittal planes; (ii) transverse measurement of upper vagina (1 cm below the cervix); (iii) pelvic flexure widthtransverse measurement of the flexure of the vagina as it passes through the pelvic diaphragm; (iv) transverse measurement of the lower vagina (3 cm above the introitus); (v) at the level of the introitus (transverse measurement of the vagina 1 cm above the introitus). An example of a measurement in the transverse plane is demonstrated in Figure 2. Measurements at all five demarcated areas were assessed as demonstrated in Figure 2. Surface contact is a summary measurement of the dimensions of the vagina and is calculated by the summation of length of the fornix (AP plane) and the transverse measurement at the four other demarcated sites (Pretorius et al., 2002).

Figure 1.

This figure represents a sagittal image of the human vagina. For illustration purposes this is an image that contains gel mixed with gadolinium contrast (white) to demarcate the vaginal canal. The outline of the vagina can be seen from the cervix and linearly to the introitus. The length of the curved line in the vertical plane is the linear length of the vagina. In this case, the measurement was 63 mm.

Figure 2.

Panel A represents a sagittal image of the human vagina. For illustration purposes these images contain gel mixed with gadolinium contrast (white) to demarcate the vaginal canal. The outline of the vagina can be seen from the cervix (above the dotted line) and linearly in the vertical plane to the introitus. The lateral dimensions of the vagina are measured in the transverse plane as depicted by the dotted line in Panel A. The image is 90 from the vertical plane. Panel B represents complete cross section of the vagina in the transverse plane (1 cm below the cervical os), as the vagina can be seen contiguously from left to right. In this instance, the measurement was 22.5 mm. Surface contact is the sum of the transverse measurements at five demarcated sites in the vagina.

The data were manually checked for any discrepancies resulting from illegal values, extreme outliers and suspicious combinations. We explored various analytical techniques, statistical methods and experimental designs to determine the optimal use of MRI to study the baseline vaginal dimensions. Comparisons using Wilcoxon signed rank tests were made at each distinct measurement within the vagina. SAS (Cary, NC, USA) software was used for statistical analysis.

Multivariate statistical methods were used to summarize the measurements derived from images in the most efficient manner. Repeated analysis of variance and related methods such as mixed effects models were used. Standard data reduction techniques such as principal components and factor analyses were used to form a reduced set of variables. For dichotomous and discrete variables we used appropriate methods such as logistic regression or generalized estimating equation (GEE). All P-values were produced using Fischers exact tests methods. The association of baseline vaginal dimensions with age, race, gravity, parity, height and weight were determined.

Data from 28 volunteers were included in the analysis. The average age of the participants was 29.2 5.8 years with a range of 1839 years. The average height was 1.66 0.05 m with a range of 1.51.7 m. The average weight was 70.13 12.6 kg with a range of 49.995.3 kg. The ethnic distribution of the participants was as follows: 17 were Caucasians, eight African-Americans, two Hispanic and one Asian/Pacific Islander. Of the participants, 14 women were nulliparous and 14 were parous.

Most women (23) participated in one trial; one woman participated in all five. Seventy-seven MRI measurements were performed at baseline (minimum one and maximum twelve per subject). Thirteen of the 28 women had more than one baseline MRI either in the same study or in a second study.

The mean dimensions of the resting human vagina are presented in Table I. These represent the average of the mean values of each of the 28 women. In other words, the average dimensions (and SD) for each woman was calculated if she had more than one MRI. Average dimensions and SD were then calculated for all 28 women. Also presented in Table I are data about the SD of the mean for each woman (within subjects) and the SD of the mean for the population of 28 women (between subjects). The SD within subjects was noted to be significantly less than the SD of the mean for the population of 28 for all individual and summary measurements.

Dimensions of the human vagina with comparison of inter- and intra-person standard deviation

Dimensions of the human vagina with comparison of inter- and intra-person standard deviation

The average linear length of the vagina was 62.7 mm with a relatively large range (40.895 mm). It was noted that the width of the vagina varies throughout its length. The transverse diameter of the vagina is the highest at the level of the vaginal fornices (41.87 mm). The transverse diameter then progressively decreases from the cervical os (32.52 mm) to the pelvic flexure (27.97 mm), mid-lower vagina (27.21 mm), to the narrowest part of the vagina at the level of the vaginal introitus (26.15 mm).

Table II gives results of evaluation of the relationship between baseline vaginal dimensions and covariates of age, weight, height and parity. Surprisingly, there were very few statistically significant associations noted with multivariable analysis. Race was not associated with any differences in measurements of vaginal dimensions. Parity was more predictive than gravidity; hence it was used (and gravidity was eliminated) in the final models. Associations noted were between (i) parity and length of vaginal fornix, (ii) age and vaginal width at the pelvic flexure and (iii) height and vaginal width at the pelvic flexure. A nonstatistically significant trend was noted between the overall length of the vagina and weight (P-value = 0.07).

Factors that affect the baseline dimensions of the human vagina

Factors that affect the baseline dimensions of the human vagina

Neither a single shape nor one summary measurement can characterize the dimensions of the resting vagina in women of reproductive age. Using a noninvasive imaging modality we were able to gain some insight into the anatomy. We confirmed that the axis and dimensions of the upper and lower vagina are different (data not shown). The axis of the lower vagina (from the introitus to the pelvic diaphragm), in relation to a standing woman, is vertical and posterior. The upper vagina changes its axis at the level of the pelvic diaphragm (from the pelvic diaphragm to the cervix), and it becomes more horizontal. We have previously noted that the transverse shape of the upper vagina at the level of the cervix is not always an H and instead is often a W (Barnhart et al., 2004). We also note that measurements of the transverse diameter of the vagina vary along its length. The width of the vagina is narrowest at the level of the introitus with minimal change in width noted at the level of the pelvic diaphragm. Above the pelvic diaphragm, the transverse width of the vagina is greater, around and behind the cervix (the transverse width of the fornix).

The differences in dimensions of the vagina along its length most likely result from the constriction by the surrounding pelvic tissues and the intrinsic compliance of the vaginal walls, resulting in the greater width and compliance of the upper vagina. The differences in the axis and the width of the vagina may not be readily appreciated by the clinician as an inserted speculum straightens the axis of the vagina. Once the speculum is opened, it is sometimes difficult to appreciate the differences in width along the length of the vaginal canal.

There are differences in vaginal dimensions among women. The length of the vagina (from external cervical os to introitus) ranged from approximately 4.19.5 cm, a greater than 100% difference from the shortest to the longest length. There was also a large range in the width of the vagina at all demarcated sites measured. The width and the range of the width tended to increase from the introitus to the fornix. The largest range in the width of the vagina was noted in the width of the posterior fornix, which in the undistended vagina is the portion of the vagina behind (posterior) to the barrel of the cervix. The cervix extends from the upper wall of the vagina into the canal with the external os pointing in the general direction of the introitus. The area of the vagina cephalad to the external os, thus posterior to the barrel of the cervix, is the fornix. Using MRI we were able to measure the posterior fornix in both the transverse plane (right to left) and in the longitudinal plane (in the sagittal plane). Thus, the true length of the vagina is the length from the external os to the introitus plus the longitudinal length of the posterior fornix. These two aspects in length, however, are not in the same linear plane, and the connection between these two lengths will also often include some change in linear direction.

Interestingly, while there were differences in vaginal dimensions among women, there were only small differences in the dimensions when the same woman was imaged multiple times. Over the course of these trials, some women had repeated measurements as much as six months apart, and there was very little variation in these measurements, suggesting that the anatomy does not change substantially over short periods, and measurements using MRI have low intra-person variability.

Notably, few statistically significant associations could be drawn between the potentially influencing factors and baseline dimensions of the vagina. Although it has been suggested that there are racial differences in vaginal dimensions, our data did not demonstrate any such clear-cut differences. We noted that age of a woman is associated with an increase in the transverse diameter at the pelvic flexure. This is consistent with the clinical finding of increasing laxity of the vaginal walls in women of advanced age. Interestingly, by contrast, height of the subject was negatively associated with width of the vagina at the level of the flexion. Weight of a woman tended to be positively associated with overall length of the vagina and presented as a nonstatistically significant trend (P-value 0.050.10). Given the number of statistical comparisons performed in this study, it is possible that some of these findings may be due to chance.

Surprisingly, parity had little association with the overall surface contact and length of the vagina. Parity is associated with a significant increase in the length of the vaginal fornix. The potential effect of parity may be via stretching and elongation of the birth canal at the time of vaginal childbirth. This effect is especially significant in the upper part of the vagina where the dilation, thinning (effacement) and taking up of the cervix is an active process, as opposed to the lower vagina where passive stretching takes place during parturition.

Our summary measurement of surface contact is not a true measure of surface area. It was devised to objectively compare the spread of a vagina gel under experimental protocol to assess the effect of a variable such as time since insertion or gel volume. It is notable that our summary measurements of 137.58 18.37 mm with a range of 103.9165 mm appear to be larger than estimates of surface area reported in other studies. Prior studies that used casts to measure vaginal dimensions reported a surface area of 87.46 mm2, SD 7.8 mm2 and range 65.73107.07 mm2. A direct comparison of these measurements cannot be performed due to differences in methodology and because the casts showed either extrusion of cast material by a small vagina or improper filling in a roomy vagina, leading to understated measurements (Pendergrass et al., 2003). Our measurements of the width of the vagina are similar to those reported, which range from 23.9 to 64.5 mm (Pendergrass et al., 1996, 2003). However, we are unable to characterize the shape of the vagina as a heart, slug, pumpkin seed or parallel sides as suggested by other studies (Pendergrass et al., 1996, 2000, 2003).

The dimensions and shape of the vagina are of great importance in medicine and surgery; however, there appears to be no single way to characterize the size and shape of the human vagina. Although differences exist between women, there are few covariates associated with these differences. There does not appear to be large variation in the dimensions of the vagina within the same woman. Given the large range in the dimensions noted, it is most likely that one size for a vaginal device will not fit all women (Mauck et al., 2004). Prior research has shown that using a single size for fitting two cervical caps leads to the correct fit in only 33% of women. Moreover, it is possible that one volume of a gel intended to cover the vaginal epithelium may not be appropriate for all women. This information can be used to better design various devices used in the vagina. We have previously proved that deployment of a potential microbicide gel in the upper and lower vagina is affected by factors such as ambulation, time since insertion, volume and product (Barnhart et al., 2005). Baseline vaginal dimension may also be an important factor.

Support for this subproject [CSA-03-333] was provided by the Global Microbicide Project [GMP], a program of CONRAD, Eastern Virginia Medical School. The views expressed by the authors do not necessarily reflect the views of CONRAD or GMP.

, Lee RA and Berquist TH (

1990

Obstet Gynecol

76

846

, Stolpen A, Pretorius ES and Malamud D (

2001

Human Reprod

16

1151

, Pretorius ES and Malamud D (

2004

Fertil Steril

81

1383

, Pretorius ES, Marunich R and Hummel A (

2004

J Reprod Med

49

83

, Pretorius ES, Timbers K, Shera D, Shabbout M and Malamud D (

2004

Contraception

70

498

, Pretorius ES, Shaunik A, Timbers KK, Nasution M and Mauck C (

2005

Contraception

72

65

, Pretorius ES, Timbers K, Shera D, Shabbout M and Malamud D (

2005

Contraception

71

357

, Pretorius ES, Shera DM, Shabbout M and Shaunik A (2006) A optimal analysis of the distribution of a microbicide. Contraception 73, 8287

and Schoemaker DM (

1983

A Cross Section in Anatomy

(

1943

An Atlas of Anatomy

123

, Nicholls RJ, Kamm MA, Hudson CN, Beynon J and Bartram CI (

1993

Br J Surg

80

508

(

1888

and Evans TN (

1978

The Human Vagina

, Lai JJ, Schwartz J and Weiner DH (

2004

Contraception

69

263

and Vaqueno E (

The rest is here:
Baseline dimensions of the human vagina | Human Reproduction | Oxford ...

Author Dr. Carole Hooven.

Evolutionary biologist Carole Hooven says that sex is real its biological. Its in your body. Its not in your head. Hooven has served as the co-director of undergraduate studies in Harvard Universitys Department of Human Evolutionary Biology, and she is aware that such statements might be seen as shocking in certain environments. Your bodys plan for gamete production has a lot of implications, but it doesnt dictate anyones value or rights, and it shouldnt in some places, sex is important. Like maybe in sports. Maybe in prison cells. Maybe in the data that we collect about sexual violence, she says.

Hooven believes that it is important to be able to talk about sexual differences in order to make the best decisions, and that it is necessary to include data from scientific research in such discussions. With that in mind, Hooven wrote the book T: The Story of Testosterone, the Hormone that Dominates and Divides Us. In it, she draws on her experience as a professor of human evolutionary biology to analyze studies about the role the hormone plays in sexual differences in both humans and animals; she combines that data with personal stories to support her thesis.

In a video call, the professor says she understands, in part, misgivings about certain claims made in the name of science. There is obviously a history of science being misused as a justification. You know, if I say that I think women have a nurturing instinct that is stronger than in men, maybe some politicians will come out and say, well, then women need to be the ones to stay home with the kids. No, thats not how it works. So, thats the connection I want to break: the link between what is natural and what society should be, she argues. I understand the resistance to just getting the facts out, but the answer to that problem is not to lie to people about reality.

Question. Do you believe that gender roles arise from biological preconditions, that they are not entirely created by culture?

Answer. So, nothing that is as cultural and complex as gender roles is totally social or totally biological. Every culture has something like sex roles. Gender is a complicated term, so for now Im just going to say sex roles. So, standards and norms of behavior for males and females, every culture has them. And there are some very strong and consistent norms across cultures that also are consistent with what we know about biological differences in humans and non-human animals. All cultures have norms about sexual behavior and regulating sexual behavior to some extent, and most incorporate greater latitude for male sexuality than for female sexuality. So, thats something that is fairly consistent across cultures that I think has a strong biological influence.

But culture is extremely important in terms of shaping how sex differences that may have biological roots manifest themselves within a society. There are patterns that are very basic, like those differences in sexual behavior that are never reversed in any culture. Like, theres no culture that I know of where female promiscuity is celebrated and encouraged, and male promiscuity is sometimes punished severely. That just doesnt really exist. And although theres variation in standards for female promiscuity and variation in standards for male promiscuity, you never see that basic pattern reversed.

That was just an example for sexual behavior. But when it comes to aggression and norms for the expression of male and female aggression, there are patterns there that arent reversed either. For example, patterns where female physical aggression is celebrated and rewarded and male physical aggression would be punished. So, I think those very basic patterns are strongly rooted in biology, but the way that theyre expressed and the specific norms in any society are a product of culture. Culture is influenced strongly by biology, and biology is also influenced by culture.

Q. When addressing these issues, some people are afraid that looking for or recognizing differences between the sexes is a way of justifying inequalities.

A. Well, if we find that there is a strong genetic influence on male promiscuity, if thats true, and I think it is true, then does that mean that its okay for men to cheat on their wives? Does that mean that they can never change that behavior? Well, no. But it does mean that theres a reality there that we have to understand and work with so that we can accommodate the reality of male sexuality instead of denying it, as many, many people do. Many feminists in particular seem to be under that misapprehension, or theyre intentionally misconstruing the evidence in order to try to achieve sex equality.

There are a lot of social problems caused by the differences in sexual appetite between the sexes and what that means for relationships, what that means for society, what that means for happiness and thriving. So, the solution, first of all, is to stop denying the facts, because I think this just causes suffering and makes it harder for us to maximize human thriving. So, first of all, one of the facts that we should be teaching and spreading through journalism and education in the classroom is that just because something exists in nature does not mean that its right or good. You know, illness is not good and thats natural. I dont think we should have to show that something is natural in order for it to be good. Just because something is innate does not mean that it is destiny or that individuals dont have any control over their behavior.

Suppose that male aggression, higher rates of physical aggression in males, is due to having a Y chromosome, which ultimately leads to high testosterone, which leads to a higher predisposition for physical aggression. Well, we already know that the environment makes a huge difference. Cultural norms make a huge difference in the extent to which individuals express physical aggression and might get into bar fights or commit murder or rape. We can see that just by looking at different cultural norms in different societies. In some places in the world theres no strong norms against rape and its even encouraged in some places and situations. In others, it is severely punished. So, biology is not destiny.

And if we can recognize those facts about the naturalistic fallacy and the myth of biological destiny, then it makes it easier for us to talk about reality and the changes that we can make socially in terms of policies and laws.

Q. In the book you talk about a fundamental difference between men and women, and between males and females in other mammals. The former continuously produces many small and, to some extent, cheap reproductive cells (sperm), and the latter produces large cells (eggs), which are much scarcer. This means that throughout history the two sexes have had different incentives with respect to their behavior and that has caused tension between the coexistence of the two.

A. If youre not an evolutionary biologist, its difficult to historically appreciate the depth of over a billion years of sexual reproduction, and this has become elaborated and elaborated and elaborated on as behavior. So, when were looking at mammals who bear the time and energetic costs of internal fertilization, you know, its not like fish or frogs or something. Its that we not only have internal fertilization, internal gestation, and once we actually expel the offspring to the outside world its almost like its still in us because were still growing it with our bodies, you know, breastfeeding. This is a tremendously impactful imbalance in reproductive investment.

So, the way we live now is weird, just bizarre from an evolutionary point of view. Were kind of freed from that energetic burden but our psychology hasnt been completely released from that lifestyle, those needs. Women typically want to have fewer sexual partners for a reason, because each potential conception is a large energetic burden, whereas it isnt for men. So we still retain these differences in reproductive psychology, and sex hormones and the differences in sex hormones really do condition and promote a lot of these differences.

I dont know of any culture in which female promiscuity is celebrated and encouraged and male promiscuity is severely punished

These differences are not just limited to sex and aggression. As it turns out, there are differences in professional interests. Women are more likely to go into helping, nurturing professions, and men are more likely to go into professions that involve more risk and risk-taking. Physical risk-taking is one of these sex differences because it could shorten a mans life relative to not taking those risks. If taking risks has strong reproductive payoffs, that can outweigh the costs or the risks of dying, basically. So, for men, physical risks have reproductive payoffs, but thats not necessarily true for females who need to live a long, healthy life to maximize their reproduction.

So yeah, there are these differences. The evidence for hormonal contributions to these differences is not as strong as the evidence of hormonal contributions to sexual behavior and physically aggressive behavior. I think culture does play a strong role there, but its hard to know because we have these sex roles where those kinds of differences are reinforced culturally. So we cant really know how much is biological, how much is cultural. We know that there is a strong interaction there. But my personal view is that striving for equality of outcome meaning we have equal levels of men and women across different professions seems totally misguided to me, because I do think there are differences in preferences. And I think what we should strive for is equality of opportunity and equality of pay. It would be great if teaching and caregiving, say, nursing, paid more than they do because these are more female-typical professions. But males are involved in professions that are pretty brutal in terms of their physical demands, and they deserve to be compensated for that too.

Q. But changes in an ecosystem change the biology of the animals that live in it. In an environment where theres less need for aggression to get ahead or to mate, would testosterone levels also drop?

A. Its hard to gather really good data [on testosterone, aggression and cultural differences]. Say we compare people in Europe with people in Japan. We know that there are testosterone differences that vary with ethnicity. And that has to do with something called a polymorphism that exists in the gene codes for the testosterone receptor. So there are differences genetically in the testosterone receptor that make it more or less responsive to testosterone. So you can take two guys who have the same level of testosterone. They can be of different ethnicities or not. But if you just look at the length of this CAG repeat in the gene, people who have longer CAG repeats have less active androgen receptors, and people who have shorter repeats have more active androgen receptors. So, for the same amount of testosterone, you could have very different effects individually.

There are studies showing that men in East Africa who live as hunter gatherers, the cultural norm is for [those] men to be very involved with their kids, to have lots of physical interaction in terms of carrying and feeding them, playing with them; fatherhood is really valued. And in those men, testosterone levels are lower, and they go down when the babies come. So, this is something that characterizes fathers everywhere in humans and in only less than 5% of mammals do we see male paternal investment where the fathers actually stick around and help to take care of their offspring. So, this is the case in humans, but it depends, of course, on the environment. And in environments where males do provide for their offspring, the offspring are more likely to survive, and the mens testosterone tends to decline. That is a product of the culture. Thats because the cultural norm is for men to invest in their offspring. Theres another African group where men do not invest in their offspring, its kind of a warrior culture. Those men have babies and are in the same ecological environment, but their behavior is different. Theyre not investing in their offspring in terms of actual interaction with them. So, in those men, we do not see a decline in testosterone.

Cultural norms can shift. Testosterone can reduce testosterone. And we do see this consistently in men all over the world who are highly involved with their kids, especially when theyre little. But I cannot really say that we have evidence that any cultural norm has changed a level of aggression. You know, we can attribute a change in testosterone to a reduction in aggression. Im not sure I could say that it is lower testosterone in any culture that is then also causally related to low aggression and relatively low aggression in that culture. But it could be. I think that could definitely be.

In environments where men take care of their children, the offspring are more likely to survive and mens testosterone levels tend to drop

Q. In the book you talk about differences between gay and lesbian behavior. Could this have to do with the way men and women are brought up, regardless of whether they are gay or straight, or can it be explained by biological differences to some extent?

A. Homosexual men have way more sex and way more sex partners than lesbians. Its a fact. Its a pattern. Everybody knows this is true, its totally fine. Theres no, like, moral judgment here. This is an observation. But the reason that gay men are having more sex is because they can. And because of testosterone. We know from studies on people who transition from one sex to another, or from one sex role to another, females who take male levels of testosterone as part of a gender transition report, pretty much across the board, with some variation obviously, but on average, the sense that a female gets when she takes male levels of testosterone is, whoa, this is the way that males go through the world. They start really obsessing about body parts, for one thing. This is somewhat consistent with the literature. So if you look at the scientific literature, its clear that sex drive is one of the strongest psychological responses from taking testosterone, that it really cranks up when you go from living as a woman to living as a man and take male-typical levels of testosterone. And Ive had many conversations now with trans men and trans women, as I did in the book. Its sort of mind-blowing for a female to start living as a male with high testosterone and to feel how strong the sexual urges are.

Not only does the libido really shoot up, but the nature of sexual attraction changes. And again, this isnt true for everyone, but many females who transition into living as males also feel this reduction in the requirement for emotional intimacy before sex. And there is that increased attention to the body and an increased attraction to the body as a sexual object, as opposed to the sense that sex and sexual attraction are about a whole human being. So this is something that actually happens: sexual objectification sort of rises with testosterone.

And we see the same thing happen in the other direction when males transition and start living as females: we see a reduction in their sex drive, which many trans women say is a relief. And its not that theyre not horny. Its not that they dont get pleasure from sex. Its just that its not the same intense drive that it was when their testosterone was high.

Read the rest here:
Carole Hooven: Its obvious that men are much more driven by sex than women - EL PAS USA

In Europe, this war climaxed with the enclosures, a process of privatisation that kicked peasants off the land and forced them to take on what work they could find in towns and cities. In Africa, Asia and the Americas, the class war took the form of genocide, enslavement and indentured labour.

Capitalism could have never happened without this theft: it provided the capital needed to drive the industrial revolution. Federicis contribution was to show that the theft of womens bodies and labour was just as indispensable to kick-starting capitalism.

All that genocide and land grabbing had inconvenient side effects. According to Federici, the population of South America dropped by 75 million while in Europe the enclosures helped generate the first modern inflation crisis, by allowing landlords to raise rents and merchants to hoard grain and hike prices. Real wages fell by two-thirds.

The starving poor had little resistance to plague or smallpox and populations began to decline. In Germany one third of the population was lost by the early 1600s.

From a commercial viewpoint, this decimation of the population was bad news. In the 1620s and 30s, markets shrank, trade stopped and unemployment became widespread, in the first international economic crisis, otherwise known as the General Crisis. The fledgling capitalist economy was on the verge of collapse.

What could be more logical, then, for the new ruling alliance than to seize control of womens bodies and their reproductive powers?

Women werent hunted at random. Witches were usually poor and were frequently accused either of crimes against property or of reproductive crimes. They were tried for procuring abortions, murdering children, sucking their blood, and making potions of their flesh.

Many witches were midwives or wise women, traditionally the holders of womens reproductive knowledge. In the Middle Ages, women had some access to contraception in the form of herbs turned into potions and pessaries, but now this was proof of the devils work.

When my friend Tim said that the government should protect unborn babies from the people gestating them, he was probably unaware that its only in the last few hundred years that the uterus has become the business of the state.

Federici described a process whereby male doctors took over birthing chambers. Strict laws were set around reproduction, on punishment of beheading. Womens sexuality ceased to be something for women to enjoy and was put to the service of the economy and of men.

Accompanying this assault on womens bodies was a devaluing of their work, and a redefinition of womanhood itself. The heterosexual, patriarchal family became the engine of the new economy. Strict gender roles were assigned. The womans place was now seen as being in the home, and all the work they did there was designated as non-work.

Non-work included all reproductive labour: both in the sense of literally having babies, and all the care and domestic work needed for humans to sustain and reproduce themselves. Not only were women expected to do all this reproductive work for free, they were supposed to do it with a smile on their faces, born out of that handy thing called maternal instinct.

This is not to say that under feudalism there was no gender inequality. But capitalism didnt exactly spell progress. The devaluing of womens work also affected their earning power when they did try to earn a wage. According to Federici, in 14th-century western Europe, women received half the pay of men for the same task. By the mid-16th century they were getting a third of the male wage.

For Federici, just as capitalism was grounded on genocide, slavery and land theft, it was grounded on womens free and cheap labour, taken from them by fire.

It wasnt by chance that Federici chose to write her history of capitalism during the 1990s and early 2000s. She was witnessing a new phase of capitalism, a new class war and a new war on women.

This was the era of globalisation and structural adjustment. The previous, social democratic phase of capitalism that had been built after the Second World War had ended in a deep stagflation and oil crisis. From the 1980s, neoliberalism was the response of business leaders and governments around the world.

Central banks hiked interest rates, inducing a deep recession. Governments and employers launched an onslaught on trade unions and wages. The IMF and World Bank forced newly independent countries to sell off land and resources to foreign corporations, cut public spending and worsen labour conditions in response to a debt crisis triggered by the interest rate hikes.

Governments and mass media criminalised migrants, cheapening their labour. And police forces and judiciaries incarcerated working class Black and brown people on a mass scale.

At the same time, Federici was seeing a feminisation of poverty (a widening gap between men and women living in poverty) and a surge in violence against women. In South Africa, Brazil and other places, this included actual witch hunting, often targeting those who fought back against corporate land grabs.

Neoliberal politicians like Ronald Reagan, Margaret Thatcher and Augusto Pinochet, though they had mixed records on abortion, espoused family values: the cis-gendered, heterosexual, patriarchal family model that had been forged centuries previously by Federicis witch hunters.

The parallels with today are too glaring to ignore. What with the climate apocalypse, the 2008 financial crash and its eternal aftermath, the COVID pandemic and now the new stagflation crisis, capitalism has utterly shat the bed. In response, capitalists and states have sought new money-making opportunities, requiring fresh onslaughts in the class war.

Central banks are again hiking interest rates. Corporations are grabbing land in response to the food and climate crises. Governments and firms have launched new attacks on trade unions, new privatisation and austerity drives, and new attacks on migrants. Debt has rocketed and wages are falling at record rates while profits are soaring.

Original post:
Capitalism and the crisis of reproduction - Open Democracy

The Human Rights Council this afternoon held its annual discussion on the integration of a gender perspective, focusing on overcoming gender-based barriers to freedom of opinion and expression. It also continued its general debate under agenda item four on human rights situations that require the Councils attention.

Introducing the annual discussion, Peggy Hicks, Director of the Thematic Engagement, Special Procedures and Right to Development Division of the Office of the High Commissioner for Human Rights, said freedom of opinion and expression was essential for the protection of every human right; the realisation of achieving this right was essential for achieving gender equality. There were new and growing threats to women and girls who spoke out in defence of their rights. Gender equality needed to be achieved. Measures to achieve this should include eliminating repressive legislation, adopting special measures for social protection, and including womens rights in school education.

Irene Khan, Special Rapporteur on freedom of opinion and expression, said the Internet had become the new battleground in the struggle for women's rights, amplifying the opportunities for women to access information and express themselves, but also creating new risks of repression and inequality. There was a clear link between the root causes of gender inequality, and the persistence of gendered censorship. Governments must abolish laws, policies, and practices of gendered censorship, and be more proactive in dismantling the structural and systemic roots of gender discrimination.

Mariana Duarte, Programme Officer, Gender Partnership Programme, Inter-Parliamentary Union, said that the main gender-based barrier observed by the Inter-Parliamentary Union on freedom of opinion and expression for women in politics was gendered violence. This violence was directed at women as a group, and aimed to eject them from the political arena. Eliminating gender-based violence in politics was essential for women to exercise their right to freedom of opinion and expression. It was also a guarantee for the effectiveness of parliament, for genuine democracy and for gender equality in society.

Julie Posetti, International Centre for Journalists, said gender-based online violence against journalists was one of the most serious contemporary threats to press freedom and the safety of women journalists internationally. It aided and abetted impunity for crimes against journalists, including physical assault and murder. It was designed to silence, humiliate, and discredit. The Human Rights Council could contribute to raising awareness of violence against women journalists by, among other points, ensuring that mechanisms and protocols to defend the safety of journalists and end impunity explicitly addressed violence against women journalists.

Mitzi Jonelle Tan, Convenor and International Spokesperson, Youth Advocates for Climate Action Philippines, said across the world the dangers against environmental defenders and activists were rising. Young girls, especially those most economically marginalised, who were ghting for human rights and climate justice were often belittled, pushed aside, and tokenised. Sexual violence was also used to silence women defenders, much of which was underreported. There should be more stringent rules on protecting human rights abuses against women.

In the ensuing discussion, speakers said overcoming gender-based barriers to freedom of opinion and expression could be extremely challenging, as these barriers were often rooted in social attitudes, cultural norms and patriarchal values, besides being imposed or integrated in discriminatory laws, policies and practices. Moreover, some harmful, implicit social norms often constituted root causes for gender-based discrimination and for undermining womens and girls rights, including freedom of opinion and expression, both online and offline. The international community needed to invest more to ensure that girls and young women could openly form their opinions in all spheres of public domain, including within this Council and other United Nations fora.

Speaking in the annual discussion were the European Union on behalf of a group of countries, Lithuania on behalf of a group of countries, Chile on behalf of a group of countries, Slovenia on behalf of a group of countries, Bahamas on behalf of a group of countries, Netherlands on behalf of a group of countries, Belgium on behalf of a group of countries, Australia on behalf of a group of countries, Israel, Egypt, International Development Law Organization, Timor-Leste on behalf of the Portuguese language countries, Ecuador, Luxembourg, Republic of Korea, Ireland, France, United Nations Childrens Fund, Colombia, United Nations Women, Afghanistan, Cyprus, and United States.

Also speaking were the Federation for Women and Family Planning, CHOICE for Youth and Sexuality, Centro de Estudios Legales y Sociales Asociacin Civil, Indonesia, Plan International Inc, Stitching Global Human Rights Defense, and Asia-Pacific Resource and Research Centre for Women.

In the general debate on agenda item four, some speakers said accountability must be ensured for all violations of the rights of indigenous and minority peoples. Violence against human rights defenders must also come to an end. The High Commissioner had a mandate to report on violations of human rights and to oversee progress made. Upholding the rights to freedom of assembly and of peaceful expression was crucial for the protection of human rights. Human rights were indivisible and all inherent to the dignity of the human person, whether economic, social and cultural rights or civil and political rights, and required the equal treatment and observation of the Council. There was a wide repression of womens rights, with an erosion of their rights to be seen in many areas of the world, with a rise in gender apartheid, which required collective action against institutionalised discrimination. The Council should ensure utmost transparency when dealing with human rights matters and that the principles of the United Nations Charter were fully respected.

Speaking in the general debate were Iceland, Israel, Bahrain, Ireland, Russia Federation, Australia, Afghanistan, Austria, Cyprus, Norway, Lichtenstein, Estonia, South Sudan, Denmark, Azerbaijan, Canada, Uruguay, Belgium, Kenya, Sweden, Georgia, Democratic Peoples Republic of Korea, Burundi, Kyrgyzstan, Barbados, Spain, Syria, Switzerland, Trinidad and Tobago, Iran, Nicaragua, Cambodia, Belarus, Algeria, Sri Lanka, Viet Nam and Egypt.

The webcast of the Human Rights Council meetings can be found here. All meeting summaries can be found here. Documents and reports related to the Human Rights Councils fifty-first regular session can be found here.

The next meeting of the Council will be at 10 a.m. on Tuesday, 27 September when it will hold a panel discussion on the right to work in connection with climate change actions, followed by the continuation of the general debate under agenda item four.

General Debate on Human Rights Situations that Require the Councils Attention

The general debate on agenda item four on human rights situations that require the Councils attention started in the previous meeting and a summary can be found here.

Discussion

Some speakers said accountability must be ensured for all violations of the rights of indigenous and minority peoples. Violence against human rights defenders must also come to an end. The shrinking of civic space in many parts of the world was of grave concern. The High Commissioner had a mandate to report on violations of human rights and to oversee progress made. Upholding the rights to freedom of assembly and of peaceful expression was crucial for the protection of human rights. Human rights were indivisible and all inherent to the dignity of the human person, whether economic, social and cultural rights or civil and political rights, and required the equal treatment and observation of the Council.

There was a wide repression of womens rights, with an erosion of their rights seen in many areas of the world, with a rise in gender apartheid, which required collective action against institutionalised discrimination. The response of the Human Rights Council and the Special Procedures could be further strengthened, commensurate to the situation on the ground, some speakers said. It was important to hold the perpetrators of gender-based violence to account. Countries that respected womens rights were generally more peaceful, with a more stable economy, and should therefore work to respect womens independence and protect their rights to a greater extent. Denying girls access to education impeded their social and economic development.

Human rights were a prerequisite for sustainable development, and human rights issues ought to be dealt with on the global stage through technical cooperation and assistance on the request of the country concerned, so that human rights projects could be supported, in full respect of the sovereignty of all countries, bearing in mind the cultural and historical specificities of each State, a speaker said. There should be greater international cooperation. The world was witnessing human rights violations and violations of fundamental freedoms, and a greater dialogue, including civil society, should be built throughout the world, ensuring States priorities were respected. One speaker said the inconsistent application of human rights standards was harmful to the agenda of the Council, which should engage in dialogue on contentious issues, in a balanced manner, as it sought to promote and protect human rights around the world.

One speaker said item four on human rights situations that required the Councils attention was one of the most divisive items on the agenda, as it was not always carried out in line with the principles and values that should lead the Council. The principles of impartiality and non-selectivity should be maintained. The Council was founded on the conviction that the promotion and protection of human rights throughout the world should be carried out through dialogue and with the participation of the country concerned, and this would serve the interests of the international community. The Council should ensure utmost transparency when dealing with human rights matters and that the principles of the United Nations Charter were fully respected. The independence and sovereign integrity of States were the fundamental norms governing international cooperation. One speaker expressed concern that the Council could be used to investigate matters that had not been confirmed or even authenticated.

A speaker said that while it was the weighty responsibility and sacred duty of the international community to intervene in situations of egregious violations of human rights, which had been corroborated by appropriate bodies following the requisite investigations, the untrammelled ability of individual States to conduct their internal affairs independently must not be proscribed, as it was counterproductive to the promotion and protection of human rights, and only increased polarisation among the Member States of the Council. Environments conducive to the fullest enjoyment of the rights of citizens of a country would be engendered with the cooperation of the international community through non-interference in the internal administration of the affairs of that country, and no State should impose its norms and standards upon others.

The global food security crisis and its concomitant impact on human rights was of concern to many speakers. Governments should ensure accountability and maintain stable peace. Violations of human rights and fundamental freedoms occurred in too many countries, and too many Governments used disinformation to hide their actions from the world at large: media freedom and reporting were essential to combat disinformation.

Annual Discussion on the Integration of a Gender Perspective Throughout the Work of the Human Rights Council, Focusing on Overcoming Gender-Based Barriers to Freedom of Opinion and Expression

Opening Statement

PEGGY HICKS, Director of the Thematic Engagement, Special Procedures and Right to Development Division of the Office of the High Commissioner for Human Rights , said freedom of opinion and expression was essential for the protection of every human right; the realisation of achieving this right was essential for achieving gender equality. Movements such as Me Too had swept the globe, with women taking a public stance against the sexual violence against women and girls both online and offline. Women played a crucial role in fighting systemic racial discrimination. Today, as the struggle for gender equality continued, there were new and growing threats to women and girls who spoke out in defence of their rights. Gender stereotypes and the patriarchal structure continued to keep women into lesser and submissive roles. There were many ways in which women were silenced and excluded from the public and private spaces, including repressive and discriminatory legislation, policies and practices, and religious and cultural norms which fuelled the violations of rights. Too often attacks against women were amplified and encouraged by public figures, with those engaging the attacks rarely being held accountable.

Ms. Hicks said that the digital world still offered immense possibilities of engagement and ability to drive social change, however, it was increasingly better known for the offline world where women were subject to misogynistic attacks. There had been a five per cent increase in the number of women human rights defenders and journalists who had been killed in 2021. These attacks were exacerbated for women subjected to intersecting discrimination. Barriers contributed to the progressive exclusion of women and girls from the public sphere; this urgently needed to change. Gender equality needed to be achieved. Measures to achieve this should include eliminating repressive legislation, adopting special measures for social protection, and including womens rights in school education. It was crucial to create an enabling environment for civil society to ensure advances in achieving womens human rights were upheld. The Human Rights Council had drawn attention to the violations and risks and had made recommendations to address these. The Council had an essential role to play in addressing gender-based barriers and ensuring all could contribute to society regardless of their gender.

Statements by the Panellists

IRENE KHAN, Special Rapporteur on freedom of opinion and expression , said her first thematic report had found that while there had been achievements on gender equality, expression was not free for many women and girls. The Internet had become the new battleground in the struggle for women's rights, amplifying the opportunities for women to access information and express themselves, but also creating new risks of repression and inequality. Gendered censorship was pervasive, and the monitoring, censoring, and criminalisation of women's social behaviour by States was concerning. Under the guise of protecting public morals, as seen recently in the case of Mahsa Amini, a young Kurdish woman in Iran, it could lead to serious violations of human rights, with tragic consequences. Women also played a disproportionate price for speaking out, with sexual and gender-based violence used as a weapon to silence women. While all women faced such threats, female politicians, journalists, human rights defenders, and feminist activists were particularly targeted. Unequal access to information and the Internet were major impediments to women's empowerment. Only about half of all women worldwide had access to the Internet, and that figure fell dramatically in the poorer and more remote locations of the world. Information of particular interest to women, such as data on workplace inequalities or on sexual and reproductive health, were often unavailable, outdated, or blocked.

Ms. Khan said there was a clear link between the root causes of gender inequality, and the persistence of gendered censorship. Governments must abolish laws, policies, and practices of gendered censorship, and be more proactive in dismantling the structural and systemic roots of gender discrimination. Social media platforms played a vital role in women's empowerment by enabling them to communicate, advocate, organise and access information. States must not use efforts to eradicate online violence, gendered hate speech and disinformation as a pretext to restrict freedom of expression. There could be no trade-off between women's right to be free from violence and the right to freedom of opinion and expression. The report recommended a threefold approach to avoid a trade-off, including a gender-sensitive interpretation of the right to freedom; an internationally accepted standard on what constituted online gender-based violence, hate speech and disinformation; and a calibrated approach to ensure that responses by States and companies were aligned with the level of harm. Ms. Khan encouraged the Office of the High Commissioner to explore these issues through multi-stakeholder consultations.

MARIANA DUARTE, Programme Officer, Gender Partnership Programme, Inter-Parliamentary Union , said that the main gender-based barrier observed by the Inter-Parliamentary Union on freedom of opinion and expression for women in politics was gendered violence. This violence was directed at women as a group, and aimed to eject them from the political arena. Three studies had been conducted, which highlighted percentages of psychological violence against women parliamentarians (over 80 per cent). The most common manifestation of psychological violence was sexist attitudes and remarks aiming to ignore or degrade women in politics, or to judge their physical appearance. Other emblematic examples of psychological violence included threats of death, rape, beating or abduction. The levels of such threats ranged from 42 per cent in Africa to 47 per cent in Europe. Online sexist attacks were also highly prevalent according to the three studies, especially in Europe, where 58 per cent of respondents had experienced such attacks. The studies also brought to light how multiple and intersecting forms of discrimination such as age, disability, minority group status, and marital status could lead to an exponential increase in gender-based violence against certain women parliamentarians.

Violence against women in politics required greater accountability and an urgent coordinated response from key actors at international and national levels.

Ms. Durante highlighted the importance of using existing international human rights mechanisms for addressing violence against women in politics. United Nations

mechanisms such as Special Procedures and treaty bodies could serve as important avenues for addressing individual cases. Women needed to be encouraged to use such mechanisms, and more must be done to open human rights mechanisms to cases of violence against women in politics. National reports under the fourth Universal Periodic Review cycle starting in November 2022 were due to focus more strongly on the role of parliaments in the promotion and protection of human rights.

This offered a unique opportunity for reporting States to provide information on the obstacles women faced to take part in politics without fear of reprisals, and what was being done, to address those challenges. Ms. Durante said that eliminating gender-based violence in politics was essential for women to exercise their right to freedom of opinion and expression. It was also a guarantee for the effectiveness of parliament, for genuine democracy and for gender equality in society.

JULIE POSETTI, International Centre for Journalists , said gender-based online violence against journalists was one of the most serious contemporary threats to press freedom and the safety of women journalists internationally. It aided and abetted impunity for crimes against journalists, including physical assault and murder. It was designed to silence, humiliate, and discredit. Additionally, there was a dangerous trend that correlated online violence with offline attacks, harassment and abuse. Targeted online attacks on women journalists were also increasingly networked, sophisticated, and at times State-linked.

While States were the main duty-bearers regarding the protection of journalists, with a responsibility to legislate accordingly and ensure law enforcement agencies responded appropriately, a number of governments stood accused of not only failing to fulfil their responsibility to protect women journalists, but of being actively part of the crisis endangering them. In many countries, individual political actors and parties had been identified as perpetrators, instigators and amplifiers of online violence targeting women journalists.

The Human Rights Council and its mechanisms could contribute to raising awareness of violence against women journalists by, among other points, ensuring that mechanisms and protocols to defend the safety of journalists and end impunity explicitly addressed violence against women journalists (online and offline), including the United Nations Plan of Action on the Safety of Journalists currently under review. The Council and its mechanisms could also consider a United Nations-level conduit to channel complaints against State actors engaged in targeted online violence campaigns, and social media companies which facilitated attacks on women journalists with impunity.

MITZI JONELLE TAN, Convenor and International Spokesperson, Youth Advocates for Climate Action Philippines , said across the world the dangers affecting environmental defenders and activists were rising. Existing socio-economic crises at hand led to young girls being more afraid to speak up. The lack of access to quality education added to the fear caused by societal prejudice and discrimination. Everyone should have proper access to education if there were to be solutions to the climate crisis that were led by the most marginalised and those most impacted. Young girls, especially those most economically marginalised, who were ghting for human rights and climate justice were often belittled, pushed aside, and tokenised at best, becoming a photo opportunity for world leaders and policymakers instead of actually listening to their demands for equity, and at worst being physically harassed and silenced. Sexual violence was also used to silence women defenders, much of which was underreported.

Across the world, States and human rights councils needed to actively consult women, and not just women from a certain class but those from the most marginalised classes. Marginalised women needed to be empowered with education and information, and given space in order to be active members of society, so girls education must be a priority. There should be more stringent rules on protecting human rights abuses against women, especially because in times of distress which the climate crisis would exacerbate, women and children were more prone to harassment and violence. The ght for climate justice included gender justice; it included the ght for womens liberation.

Discussion

In the ensuing discussion, a number of speakers said overcoming gender-based barriers to freedom of opinion and expression could be extremely challenging, as these barriers were often rooted in social attitudes, cultural norms and patriarchal values, besides being imposed or integrated in discriminatory laws, policies and practices. Moreover, some harmful, implicit social norms often constituted root causes for gender-based discrimination and for undermining womens and girls rights, including freedom of opinion and expression, both online and offline. It was therefore crucial to break the cycle of reproduction of gender stereotypes which ultimately impacted entire societies. Restrictions to freedom of opinion and expression could have wider impacts on human rights, and where women and girls were hindered in their expression, all were deprived of their valuable opinions. Sexual and gender-based violence, including abuse and harassment through digital technologies, was often used as a deliberate tactic to silence women and girls.

Despite the impressive and inspirational gains made by women and girls, as well as people with diverse gender identities, expression and opinion were still not equally free and protected for all persons. Currently many women and girls from diverse backgrounds faced endemic discrimination, and it was essential to establish good practice norms in the Council that aimed at the full eradication of gender-based discrimination. The Council had a mandate to ensure that this was a principle for all, ensuring the respect and guarantee of human rights for all. It was also vital to take an inclusive approach and engage men and boys when taking measures to address the safety of all journalists and other media workers. This was particularly important to effectively tackle gender-based violence, discrimination, abuse and harassment, including sexual harassment, threats and intimidation, as well as inequality, negative social norms and gender-stereotypes.

Cultural norms, gender stereotypes and ensuing discrimination online and offline continued to suppress, censor and mute the voices of women and girls. Unfortunately, women activists, politicians, human rights defenders, journalists and media workers were disproportionately targeted by State and non-State actors, including hate speech, bullying and acts of violence. Womens and girls leadership was essential to advancing gender equality. Respect, protection and promotion of the right to freedom of opinion and expression was a powerful tool to confront any form of gender-based discrimination, and lay at the heart of the international legal framework on political and civil rights. The effective exercise of the right of freedom of opinion and expression was essential for the enjoyment of other human rights and constituted a fundamental pillar for democracy. The international community needed to invest more to ensure that girls and young women could openly form their opinions in all spheres of public domain, including within this Council and other United Nations fora.

Concluding Remarks

MARIANA DUARTE, Programme Officer, Gender Partnership Programme, Inter-Parliamentary Union , said that violence against women politicians did not happen in a vacuum. By assuming a position of power, women were defying patriarchal norms and were particularly at risk. Many of the root causes were related to gender-based violence against women. A sound legal framework free from discrimination against women was required, as well as specific provisions in the law against violence against women in politics. It was important to educate men and boys from an early age. It was vital to understand and acknowledge the problem to address the issue. Perpetrators committing violence against female parliamentarians came from everywhere; their families, their party, or members of their staff. The more women there were in parliament, the more it would be accepted that they belonged where they were. If women in parliament were no longer a minority, they would be stronger. It was also important to have an institutional commitment to protect women in parliament.

JULIE POSETTI, Global Director of Research at the International Centre for Journalists , said impunity for crimes against journalists was a concerning issue; women journalists were targeted online, and were being threatened with cases of journalists who had been murdered with impunity within their own countries. Gender disinformation and gendered hate speech were key issues. These could be combatted by addressing the root causes, including structural inequality; however, these circumstances were often used to justify inaction. A book would be published in November with a 25-step plan to aid States in their responses to gender-based violence. The United Nations could not stay silent, when despots were targeting women in such ways, there needed to be a reckoning to allow women to be defended.

MITZI JONELLE TAN, Convenor and International Spokesperson, Youth Advocates for Climate Action Philippines , said gender injustices were still rising. It was not enough to have women lead - States had to go to the most marginalised lesbian, gay, bisexual, transgender and queer persons and women. States must play a role in the empowerment of lesbian, gay, bisexual, transgender and queer persons and women. Gender injustice could not be discussed in a vacuum - it had to be looked at in the context of all those who were discriminated against. Young people needed to be educated at a young age in gender injustice. Everything heard today was appreciated, but work needed to be done.

Lesbian, gay, bisexual, transgender and queer persons and young women were becoming ever more vulnerable to climate injustice. In every aspect of work, gender injustice needed to be discussed - it had to penetrate every aspect. It could not be seen just as being perpetrated by outside forces. In some countries the threats to women were not just threats to expression or opinion, but also to their rights to exist. Human rights defenders were often at the forefront of this, threatened sexually, and their families being turned away from them. These panels could not be the end - the system that was being created should not just empower women, but all people across all forms of life. Women needed to not just feel protected, but actually be safe, and to do this, there had to be a holistic approach, from communities, and in all aspects of work.

Link: https://www.ungeneva.org/en/news-media/meeting-summary/2022/09/afternoon-human-rights-council-holds-annual-discussion

Go here to see the original:
Human Rights Council Holds Annual Discussion on the Integration of the Gender Perspective, Focusing on Overcoming Gender-Based Barriers to Freedom of...

Two recently published papers have described experiments in which mouse embryo models were developed from pluripotent stem cells. Mina Popovic and Susana Chuva de Sousa Lopes from ESHREs SIG Stem Cells report.

Two research groups have recently achieved the unthinkable, demonstrating that mouse embryo models derived from stem cells have the potential to develop from pre-gastrulation until early organogenesis in vitro. (1,). The mouse embryo-like structures in these experiments were grown until the equivalent of embryonic day (E)8.5 (a third of a mouse pregnancy). Although many showed clear morphological abnormalities, some structures contained a beating heart, a brain rudiment with fore- and midbrain, patterned neural and gut tubes, migrating primordial germ cell-like cells and progenitors of other organs. Remarkably, they also developed extra-embryonic structures, such as an umbilical cord, amnion and yolk sac that formed blood islands all without the need for maternal tissues.

Over the past years, a flurry of studies have demonstrated the remarkable ability of (mouse and human) pluripotent stem cells to self-assemble into organised embryo-like structures in vitro.(3,4) While traditional developmental biology has been limited by the availability of natural (fertilised) embryos for research, this enhanced stem cell toolkit has enabled several aspects of mammalian peri-implantation development to be captured in vitro. Accordingly, blastoids have recapitulated the blastocyst, gastruloids model features of axis development and gastrulation, while various other embryoids mimic aspects of epiblast, trophoblast and (pro)amniotic cavity formation. Yet, up until now, none of these models have been able to demonstrate the full developmental potential of natural embryos.

Now, these two independent studies, published in Cell and Nature, have applied similar technologies to generate and culture stem cell-based embryo-like structures, demonstrating their self-organising capacity and unprecedented developmental potential. To generate these structures, the group of Magdalena Zernicka Goetz combined mouse embryonic stem cells (mESCs) with trophoblast stem cells, and extraembryonic endoderm-like cells, using methods previously pioneered by their own group.(5,6) The second group, led by Jacob Hanna, started solely from mESCs, yet some were made to transiently overexpress master regulatory transcription factors to induce both the trophoblast and extra-embryonic endoderm lineage. The aggregated stem cells first assembled into egg-cylinders and then further progressed into complete mouse embryo-like structures.

To maintain the embryo-like structures in culture, both groups used a platform for extended ex-utero culture of natural embryos from E5 to E11, previously optimised by Hannas team.(7) In this system, mouse embryos are cultured in glass vials rotating on a drum in the presence of rat (or human) blood serum, with an electronic ventilation system regulating gas and pressure.(8) Following extended culture on the rolling platform, the mouse embryo-like structures showed notable similarities to their natural E8.5 counterparts grown either in utero or ex-utero. Remarkably, they increased in complexity over time towards the formation of differentiated organ primordia. However, unlike natural embryos that can be cultured up to E11 using this system, the embryo-like structures could only reach the morphology of an E8.5 embryo. It remains unknown whether these differences are a result of the stem cell aggregation protocols or varying culture requirements.

Certainly, further optimisation of the technology will be necessary. A large proportion of the embryo-like structures developed abnormally, exhibiting a variety of abnormalities during ex-utero culture, including the complete lack of body segments. Of the normal egg-cylinder-shaped embryo-like structures at E5, only around 2% developed to E8.5, yielding an effective 0.1%0.5% efficiency from the total initial aggregates generated. These results were similar across both studies.

Heterogeneity during the formation of embryo-like structures also remains a challenge. Efficiency varied substantially between mESC lines, with some lines not able to generate embryo-like structures beyond E6.

Although further work is necessary to improve efficiency and reproducibility, mouse embryo-like models do hold some advantages over natural embryos. Primarily, they are more amenable to genetic modifications and may provide a powerful in vitro system for elucidating the diverse roles of genes during early organogenesis. This may ultimately reduce the need for experimental animals and natural embryos for research. Evaluating developmental pathways in greater detail than ever before could also enhance the efficiency and control of stem cell differentiation protocols for regenerative medicine.

To demonstrate the functionality of their model, the team of Zernicka-Goetz knocked-out Pax6 (a key gene involved in neural tube patterning, brain and eye development) in the embryo-like structures. Markedly, neural tube development was compromised in the structures lacking Pax6, which is consistent with natural embryos missing this gene.

Accordingly, the future development of similar embryo-like models in human may provide insights into longevity, (in)fertility and developmental diseases. Beyond basic research, Jacob Hanna is hopeful that this method may provide a source of new organs and tissues for human transplantation biotechnology. Yet, their use for reproductive purposes is not and should not be considered, especially since the embryo-like structures are in fact genetic clones of the donor stem cells used for their formation.

Nevertheless, translating this system from mouse to human will not be straightforward. Reaching these same stages of organogenesis in the human would correspond to a first-trimester fetus, a path undoubtedly fraught with technical as well as ethical concerns. In practice, capturing the length of human gestation, sheer size of human organ primordia and complexity of these developmental milestones, will certainly be an immense challenge. At present, the possibility of culturing human embryo-like structures beyond gastrulation, particularly in the absence of key maternal cellular constituents and proper implantation assays, remains unknown.

Concurrent to scientific innovation, continued ethical reflection and societal debate remain imperative. Given their benefits for research, it is reasonable to assume that the quality and developmental potential of human embryo-like structures will gradually improve. Moving forward, considering the extent to which the use of these models raises moral concerns characteristic of human embryo research will be essential. At present, it is unclear whether human embryo-like structures which mimic the intact human embryo show developmental potency beyond gastrulation because of a lack of adequate culture platforms and the 14 day rule, which prohibits in vitro culture of human embryos beyond 14 days. Last year, the International Society for Stem Cell Research recommended relaxing this standard.(9) However, any proposal for the culture of natural embryos or stem cell-based embryo models that mimic the intact human embryo beyond the current 14 day limit must gain broad public support and would require changes in national legislation.

Nonetheless, with the field of developmental biology brimming with continued efforts to refine embryo models, the stem cell toolbox is becoming increasingly valuable. We do anticipate that stem cell-based embryo-like structures will enhance the roadmap for studying early development, offering novel opportunities for exploring the early days of development in real-time and in unprecedented detail.

1. Tarazi S, Aguilera-Castrejon A, Joubran C, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell 2022; 185: 3290-3306.e25. doi.org/10.1016/j.cell.2022.07.0282. Amadei G, Handford CE, Qiu C, et al. Synthetic embryos complete gastrulation to neurulation and organogenesis. Nature 2022: doi.org/10.1038/s41586-022-05246-33. Rossant J, Tam PPL. Opportunities and challenges with stem cell-based embryo models. Stem cell reports 2021. doi.org/10.1016/j.stemcr.2021.02.0024. Veenvliet JV, Lenne PF, Turner DA, et al. Sculpting with stem cells: how models of embryo development take shape. Development 2021; 148: dev192914. doi.org/10.1242/dev.1929145. Sozen B, Amadei G, Cox A, et al. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nature Cell Biology 2018; 20: 979-989. doi.org/10.1038/s41556-018-0147-76. Amadei G, Lau KYC, De Jonghe J, et al. Inducible stem-cell-derived embryos capture mouse morphogenetic events in vitro. Dev Cell 2021; 56: 366-382.e9. doi.org/10.1016/j.devcel.2020.12.0047. Aguilera-Castrejon A, Oldak B, Shani T, et al. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis. Nature. 2021;593(7857):119-124. doi.org/10.1038/s41586-021-03416-38. Tam PP, Snow MH. The in vitro culture of primitive-streak-stage mouse embryos. J Embryol Exp Morphol. 1980;59:131-143.9. See https://www.focusonreproduction.eu/article/News-in-Reproduction-Embryo-research

Go here to read the rest:
No eggs, no sperm, no uterus: extending the boundaries of mammalian development in vitro - ESHRE

Fight disinformation: Sign up for the free Mother Jones Daily newsletter and follow the news that matters.

This story was originally published by Hakai Magazineandis reproduced here as part of theClimate Deskcollaboration.

Wearing a navy-blue polo neck emblazoned with the Florida Aquarium logo, Keri ONeil hugs a white cooler at Miami International Airport. Coral babieeeeees, she says, before letting out a short laugh. Relief. The container holds 10 plastic bottles teeming with thousands of tiny peach-colored specks. Shaped like cornflakes and no more than a millimeter in length, they are the larvae of elkhorn coral, an endangered species that is as characteristic to the reefs of the Florida Keys and the Caribbean as polar bears are to the Arctic or giant sequoias to Sierra Nevada.

With the larvae kept at 27 C inside their insulated cooler nestled in the trunk of her car, ONeil drives back to the Florida Aquarium in Tampa, where she works as senior coral scientist at the aquariums Center for Conservation. Once there, the larvae begin their metamorphosis from free-swimming specks into settled polyps, the beginnings of those branching, antler-like shapes that define this species. ONeil and her colleagues provide everything the coral needs for a strong start in life: warm water with a gentle flow, symbiotic algae that find a home inside the corals cells, a soft glow of sunlight, and some ceramic squares seasoned with algae that act as landing pads for the larvae.

The transformation of larvae into polyps was the final step in a coral breeding project that began on the shores of Curaao, an island off the coast of Venezuela, in the summer of 2018 and involved a cadre of conservationists and scientists who each specialize in one specific stage of coral development. From collection of eggs during mass spawning events to the cryopreservation of sperm, and from fertilization to larval growth, every step had to go swimmingly for the project to have any chance of success.

Its like the most stressful relay on Earth, says Kristen Marhaver, a coral scientist at the Caribbean Research and Management of Biodiversity Foundation in Curaao, who helped start this relay race by collecting eggs during a nighttime dive at a reef thats a 45-minute drive from her laboratory. As ONeil was picking up her coral babies in Miami, a second team of scientists at Mote Marine Laboratory and Aquarium in Sarasota, Florida, received its own. The pressure on both labs was immense. To fail now would be to drop the baton just before the final straight.

But, if anything, their efforts were too successful; hundreds of larvae settled as translucent and fragile blobs of tissue (each a single polyp) and then started to divide, branching into the clear waters of their shallow, open-top tanks. Elkhorn coral grows an average of five to 10 centimeters per year, a bamboo-like pace for corals in general. To stop them becoming entangled, ONeil had to cut, separate, and move her colonies to different paddle poolsized tanks over the course of the next year. We almost ended up with a six-foot-by-four-foot solid piece of elkhorn coral made up of 400 different individuals, she says. They were just outgrowing the tanks.

A juvenile elkhorn coral colony, about six months old, gets its start in a lab at the Florida Aquarium in Tampa. The eggs came from coral in Curaao and the sperm from coral elsewhere in the Caribbeanpopulations that, under normal circumstances, would not have mixed in the wild.

Kristen Marhaver

The rows of coral in ONeils tanks are a window into a former world. The reefs of the Florida Keys were once dominated by elkhorn coral. Visiting these islands that curl southward from Florida like the tip of a bird of preys beak, biologist, conservationist, and writermost notably ofSilent Spring, but also of several books on the oceanRachel Carson peered into the shallows using a water glass, an instrument akin to a glass-bottom bucket. Through this simple portal, she saw great stands of trees of stone, a forest of coral. Today, after decades of disease, coastal development, and bleaching, over 95 percent of the states elkhorn coral have been lost.

This population isnt just depleted in number, like a forest thats been felled, but is also impoverished from within. Some reefs in the Keys descend from a single individual that has reproduced via fragmentationbits break off the parent coral and start a new colony. This mode of reproduction allows corals to spread, but without the genetic mixing that comes with sex, these clones are more susceptible to disturbances such as disease.

The coral larvae raised by ONeil at the Florida Aquarium are different; they are the product of sperm and egg, a shuffling of genes, and the growth of genetically unique clumps of coral. Reintroducing them could provide a boost to the corals genetic diversitya quick stir to the gene pooland could save a denuded ecosystem. Their reintroduction could also spell its doom.

Hidden inside the genetic code of the Florida Aquariums coral is a map of an atypical origin: the eggs collected from Curaao were fertilized using sperm from the Caribbean, including Florida. Although the same species (Acropora palmata), these coral populations would never breed in the wild. The distance between the two is hundreds of kilometers and contains the island blockade of the Greater Antillesan impossible journey for any sperm. The coral housed in the Florida Aquarium are the products of human hands, the latest addition to a recentand often controversialtrend in conservation known as assisted gene flow, shuttling existing genetic diversity to new places.

Elkhorn coral spawn only once a year, triggered by the full moon, but estimating the exact time and date of the spawn is tricky. Scientists in Curaao dove for more than 40 nights before the elkhorn coral they were monitoring finally released their eggs.

Smithsonian National Zoo

No hands have offered more assistance to these coral than those of Mary Hagedorn, senior research scientist at the Smithsonian Conservation Biology Institute, who is based at the University of Hawaii at Mnoa. Hagedorn flew to the Caribbean to guide this project from start to finish. It is her research that made this work possible. Since 2004, she has developed cryopreservation techniques that can freeze coral sperm andjust as importantlykeep them fertile upon thawing.

Although cryopreservation has been used for IVF in humans and other mammals for decades, its only in the last few years that other coral conservationists have adopted Hagedorns techniques for coral sperm. At a time when these methodologies are most needed, Hagedorns work has matured into a solid science, says Tom Moore, a coral restoration manager at the National Oceanic and Atmospheric Administration at the time of this project and now in the private sector. I think were going to start seeing a lot more of this done in the course of the next few years.

Without the option to freeze sperm, coral conservationists have been forced to work within the few hours these sex cells remain viable. In Florida, Moore says, scientists from the Lower Keys would drive north to meet colleagues from the Upper Keys and swap sperm samples on the side of the road, fertilizing eggs there and then before the sperm stopped swimming. With the option to freeze sperm using liquid nitrogen, however, samples can be transported long distancesfrom Florida to Curaao, for example. Then, when eggs are collected from the reef, the sperm can be thawed and used in concentrations that make fertilization most likely. Hagedorns work opens up new possibilities that, just a few years ago, were largely ignored.

Kendall Fitzgerald, left, and Claire Lager, of the Smithsonian Conservation Biology Institute, use cryopreservation techniques to conserve coral as part of a global biorepository.

Smithsonian National Zoo

Self-funded for many years, Hagedorns research was nearly stopped altogether in December 2011. Her savings had run out and funders didnt seem to see the potential of her work. I was a month away from closing my lab, she says. Then she received an unexpected call from the Roddenberry Foundation, a philanthropic organization set up in memory of Gene Roddenberry, the writer ofStar Trek. Since Hagedorns work fit the criteria for bold and unique science, the foundation wanted to fund her research for five years. Since then, her work has grown to include frozen larvae, frozen coral symbiotic algae, and frozen coral fragments, and it has been adopted by labs around the world. To help her cryopreservation methods spread, Hagedorn runs workshops and shares her techniques freely; the instructions to build her equipment can be downloaded and then manufactured with a 3D printer.

As with IVF in humans, coral fertilization is not a perfect science. In a study published in 2017, Hagedorn and her colleagues showed that fertilization rates from frozen coral sperm are significantly lower than from fresh sperm, roughly 50 percent versus over 90 percent. And these figures were based on coral that lived as neighbors on the same reef. The researchers wanted to increase genetic diversity in the future (through assisted gene flow), but it was still unknown whether populations that had been isolated for thousands of years could produce viable offspring, especially after their sperm had been frozen. The idea to breed elkhorn coral from the Florida Keys with those from Curaao was the most extreme test yet of Hagedorns methods. It was a moonshot for coral conservation, says ONeil. We wanted to do something that had never been done before.

Marhaver thought that they had a five to 10 percent chance of success. To have hundreds of healthy coral now sitting in tanks barely crossed her mind. Conservationists are more attuned to the vibrations of endangerment, extinction, and loss. To have a moonshot succeed is unfamiliar territory. With the impossible now possible, the next hurdle is moving from the lab to the ocean, a leap that not everyone is comfortable with.

As in medical practice, the first rule of restoring ailing ecosystems isprimum non nocere, first, do no harm. And what concerns Lisa Gregg, program and policy coordinator at the Florida Fish and Wildlife Conservation Commission (FWC), the organization that decides the fate of the Florida-Curaao coral, is that they arent suited to the local conditions of the Florida Keys, a place that Carson referred to as having an atmosphere that is strongly and peculiarly [its] own.

These islands are formed from sedimentation, while those of Curaao and the eastern Caribbean are founded on volcanic activity. Plus, the Florida Keys also have their own unique combination of problems, from infectious disease to coastal development, and from hurricanes to coral bleaching. We have a lot of problems here, says ONeil. And it is quite likely that the corals that are still alive in Florida after everything thats happened to them are probably the ones that are best suited to living in Florida and providing offspring that may be capable of surviving in Florida.

If Curaao genes were introduced, they might lead to lower rates of reproduction, shorter life spans, or lowered resistance to local diseases. Imperceptible at first, such outbreeding depression can slowly weaken a population, generation by generation. To introduce genes that havent experienced the same history could be a ratchet toward extinction.

The risk of such outbreeding depression is very low, howevera doomsday forecast for Floridas reefs, many conservationists think. Im not so concerned that theres a huge risk of the Curaao [genes] causing a major detriment to the native Florida population, says Iliana Baums, head of marine conservation and restoration at the University of Oldenburg, Germany, who has studied elkhorn coral since 1998. But thats based on my knowledge of the literature for other species and modeling and so on. I dont have any direct evidence for that. Direct evidence would require reintroduction, a catch-22 of conservation; the very thing that is controversial and potentially dangerous is also the route to understanding.

Read more from the original source:
These Scientists Tried a Coral-Breeding Moonshotand It Worked Mother Jones - Mother Jones

By DAVID DUPONT

BG Independent News

Even before the U.S. Supreme Court overturned Roe v. Wade in Junereproductive freedom advocates were in action spelling out what to do when the anticipate decision was handed down.

Then on June 24, they had to spring into action.

Protests began.

Hannah Servidio, of Pro-Choice Ohio, said Thursday an educational session proceeding a rally on the BGSU campus because Ohio did not have a trigger law that put restrictions into place as soon as the Supreme Court ruled. Those had been proposed, but had yet to pass the legislature and be signed by Gov. Mike DeWine.

It so-called six-week abortion ban was tied up in the courts.

Then Ohio Attorney General Dave Yost successfully petitioned the court to lift the stay, and at 6 p.m. that day the six-week ban was in place.

Abortion clinic personnel started calling patients who were scheduled to have abortions the next day that they may not be able to have the procedure done.

The implementation of that law, however, has been put on hold based on a ruling in Hamilton County. But that stay is temporary, though clinics and the ACLU are trying to make it indefinite.

So abortions continue in Ohios nine clinics for now, Servidio said.

But that future is clouded.

Even beyond the complications posed by the government, those seeking abortions face a host of obstacles finding child care, getting time off work, paying for the procedure, transportation.

On Thursday BGSU Student Democrats and the community group Persist rallied to get supporters of legalized abortion to take another kind of action voting.

The rally began with Servidios refresher on where things stand in Ohio.

She noted to start that everyone in the room likely has had an abortion or loves someone who has had one.

Abortion is a real medical procedure, a real aspect of reproductive care that people seek every day, she said. Banning it would have real consequences for women facing a range of health issues, includingectopic pregnancies.

Rallies like the one at BGSU are necessary, she said.

Its important, she said, to have conversations about abortion, and reproduction health and what its like to live in a state like Ohio underneath the foot of the legislature that we currently have.

BG City Councilman Nick Rubando said that he is trying to ease some of the burdens by amending the citys human rights ordinance to help protect womens reproductive rights. If the resolution, which he plans to introduce in October, passes, for example, a woman would not have to worry about getting fired for taking time off to get an abortion.

After the educational session, about 150 people gathered outside the Bowen Thompson Student Union for a rally and a brief march through campus.

Jan Materni, candidate for State representative in District 3, said that women make up 51 percent of the electorate and now is the time for their voices to be heard.

Emily Gerome, the vice president of the BGSU Democrats, urged students to register to vote in Bowling Green, and encouraged those registered to help get other students sign up to vote.

The 150 participants stepped off heading toward Jerome Library chanting abortion is a right, we wont give up the fight.

Nearby about 15 antiabortion demonstrators stood silently. The two groups did not interact. That was by design.

Servidio cautioned those rallying note to engage with people just trying to bait them, and to disengage if they felt uncomfortable.

Allison Stump, Students for Life coordinator for Catholic Charities, said the counter protestors were there as peaceful, joyful witnesses to what it mean to be pro-life.

They were not there to engage in conversations. They have those in other settings.

When asked about the slogan bans off our bodies, she said, there are two bodies involved, and each body has a unique dignity as human beings.

She claimed: We understand from basic biology that the preborn are humans, and they deserve equal protection under the law.

Servidio warned that the forthcoming lame duck legislative session could be toxic, and vote to grant personhood to a fertilized egg.

View original post here:
Rally at BGSU urges action to preserve reproductive rights BG Independent News - BG Independent News

As we near the midterm elections many are asking how will the Supreme Courts decision on abortion influence how people vote? With a host of other issues like inflation, student loans, the war in Ukraine, immigration, the presidents age, and the pandemic competing for the attention of voters, just how important is the issue of abortion?

Very.

The reason is that in politics, intensity matters. Unlike every other issue pollsters ask about, abortion and the broader questions it raises about reproductive health are central to the existence of 51.1% of the population in a way that no other issue in politics is or has ever been.

From the time a young woman menstruates to the time she is done with the last symptom of menopause and beyond, women are in constant conversation with other women about the everyday reality of their reproductive organs.

For many women these discussions eventually revolve around pregnancy, and for a subset of the female population, there is an additional struggle and trauma associated with getting pregnant in the first place. The intensity of pregnancy is usually the first time in this saga that men become aware of the realities of reproduction as they learn about the dangers and problems their partners could face. For most of human history, pregnancy has been dangerous and often fatal. Women with uteri can experience ectopic pregnancies, preeclampsia, and placental complications. After these health risks comes the trauma of delivery and the possibility of fetal distress, perinatal asphyxia, placenta previa, and host of other complications that can still be fatal even with modern medicine. Most men have never heard of these complications until their wife or partner is pregnant. And after the pregnancy, men rarely talk about these issues again and they recede into the background.

This is no criticism of men, they dont live the reproductive cycle so of course they dont pay much attention to it. But it does make them less acutely aware of the enormous dangers women face when the government starts telling doctors what they can and cannot do to pregnant women. There are some things the government is simply NOT good at and dictating individual medical outcomes is near the top of the list.

So, we now face an election where that is exactly what is on the ballot. Everyone born with a uterus has an interest and a stake in the abortion issue that those without a uterus do not havemeaning, the abortion issue will be intense for a lot of people. In addition to the intensity of this issue is the sheer number of females in the population and the electorate. First, there are more women than men in America167,500,000 women compared to 164,380,000 men.

But more importantly, women vote more often than menin the 2020 presidential election, women constituted 52% of the electorate compared to 48% for men.

Small shifts in this vote yield big numbers. Take, for instance, the swing state of Pennsylvania. It, like many states in 2020, had record high turnout of 6,924,558. According to exit polls, 52% of those voters were women or 3,600,827. A shift of only 3% of the womens votes would be equal to 108,025 votes or 27,470 more than Bidens close victory over Trump.

No wonder Republican candidates are trying to soften their abortion stances. As men get a crash course in reproductive biology, more and more will have the experience that South Carolina State Rep. Neal Collins had when he regretted voting for an anti-abortion law that put a young womens life at risk and the near loss of uterus when her water broke just after 15 weeks of pregnancy.

Collins went on to vote for a less radical billone that listed 12 to 14 situations where the life of the mother would be protected. But what if there are more situations that threaten the life of the mother than the South Carolina legislature knows about? Women know that ultimately these decisions must be made between themselves and their doctors (and the men in their lives know that too). Nothing else will work, which is why the abortion issue is unlike anything else we have seen in politics.

See more here:
The abortion issue in the 2022 midtermsunlike any other issue - Brookings Institution

This photograph, taken on February 24, 2014 during an aerial survey mission by Greenpeace in Indonesia, shows cleared trees in a forest located in the concession of Karya Makmur Abadi, which was being developed for a palm oil plantation. Environmental group Greenpeace on February 26 accused US consumer goods giant Procter & Gamble of aiding the destruction of Indonesian rainforests. BAY ISMOYO/AFP via Getty Images hide caption

This photograph, taken on February 24, 2014 during an aerial survey mission by Greenpeace in Indonesia, shows cleared trees in a forest located in the concession of Karya Makmur Abadi, which was being developed for a palm oil plantation. Environmental group Greenpeace on February 26 accused US consumer goods giant Procter & Gamble of aiding the destruction of Indonesian rainforests.

Cases of monkeypox are on the rise in the U.S., with about 67,600 global cases, including about 25,500 in the U.S. Simultaneously, the world is still facing a COVID-19 pandemic, despite the number of cases tapering off.

Researchers say these types of viruses, known as zoonotic diseases, or ones that spread between humans and animals, will become increasingly commonplace as factors such as the destruction of animal habitats and human expansion into previously uninhabited areas intensify.

Monkeypox was first found in monkeys in 1958 and in humans in 1970, according to the Centers for Disease Control and Prevention.

Elements such as deforestation, population growth and animal breeding have removed the boundaries between where humans and wild animals live, bringing them into closer contact.

Since 1990, about 1 billion acres of forest have been cut own to make room for other uses. Deforestation rates have been decreasing, with an average of 25 million acres being cleared each year from 2015 to 2020, down from about 40 million per year in the 1990s, according to a United Nations report.

Besides the impact on the climate, deforestation means a loss of habitat that often ends up driving wildlife nearer to people.

"You're just seeing the effects of the change in the environment, the change in animal behavior, the change in human behavior, bringing wild animals and humans more into contact where they can have more contamination," said Lanre Williams-Ayedun, the senior vice president of international programs at World Relief, a sustainability nonprofit organization.

Those changing patterns in animal migration and reproduction can influence how pathogens behave in their natural host, possibly becoming more contagious in the process, said Dr. Carl Fichtenbaum, the vice chairperson for clinical research for internal medicine at the University of Cincinnati.

"Depending on the particular germ, when it has an opportunity to do this multiple times, the germ adapts to the new species," he said.

A United Nations study found an estimated 60% of known infectious diseases found in humans and 75% of all emerging infectious diseases are zoonotic, or transmitted between species, from animals to humans.

Some of those include Ebola, Zika and COVID-19, which scientists hypothesize started in bats.

Monkeypox is endemic, or regularly found, in some African countries. But because monkeypox can be "self-limiting" and not as transmissible as other viruses. "It wasn't something that you would have thought would become such a big outbreak," Williams-Ayedun said.

The virus was nearly eradicated at one point when people in those regions received vaccines for smallpox, a relative of monkeypox, in larger numbers. But now, vaccine rates are much lower in people 40 and younger, Williams-Ayedun said.

People are also traveling farther and more frequently these days.

"It's easy to spread diseases globally, and we've seen that something that happens in what we think is a remote part of the world somewhere can very easily become something that is a concern where we live," she said.

Luis Escobar, an assistant professor in Virginia Tech's fish and wildlife department, said that while researchers have been able to predict where small outbreaks of monkeypox are more likely to occur poorer regions, areas with war or social conflict or remote places it is in those places where data is less accessible.

"My perception is that the data may not be enough," he said. "The data may have not been enough to anticipate a global epidemic of this magnitude."

He added that scientists must survey zoonotic diseases "in all corners of the world because we don't know which [region] is going to trigger the next pandemic."

Fichtenbaum agrees, and said that with the thousands of germs in the ecosphere, it's hard to know which ones will spread to pandemic-level proportions.

"I think it would be really disingenuous if someone says, 'Well, I can predict that this germ is going to be the next big germ,'" he said. "I think we're not very good at that, in the same way that we're not very good at predicting earthquakes."

Escobar said that in looking to the future, researchers have neglected past data in their work to combat disease spread.

"The research I do is a bit to anticipate the future," he said. "But we're putting a lot of effort to try to reconstruct the past. We're analyzing data from the last century in terms of wildlife diseases, climate, forest laws in the last 100 years and with that, we are understanding what is happening now."

He and his colleagues have used that data in simulations to predict patterns in the next 50 to 100 years. But zoonotic diseases may not need that long.

Escobar's research suggests in the next 12 to 20 years, there could be a significant increase in diseases spread to humans from bats. Diseases endemic to Latin America's bat population could begin making their way to the American South as Latin America gets warmer, he said, which affects the distribution of and quantity of bats.

Additionally, diseases that are only exclusive to animals could tell us a lot about what society might look like down the line.

For example, as global warming continues to intensify, a virus common among fish could decimate aquaculture, causing blows to food production and the economy, Escobar said.

Fichtenbaum says public policy will need to address the spread of zoonotic diseases.

"I think right now, much of the climate change focus has been focused on, 'Well, this is bad for the environment, and we're going to see floods, and we're going to see heat waves, and this may affect economic survival.' But people aren't always looking at it in terms of health and human disease, which is very costly."

In recent years, some researchers in the zoonoses field of study have been pushing toward a "one health" approach, the merging of public health, veterinary health and environmental health, Ayedun-Wliliams said.

Helping people secure jobs, safe shelter and food is also important, as scarcity can result in hunting wild animals or cutting down trees for homes, and in turn, drive zoonotic diseases, she said.

Link:
Climate change is linked to the spread of viruses like monkeypox, experts say - NPR

HALIFAX, Nova Scotia--(BUSINESS WIRE)--Dr. Al Yuzpe, Chief Medical Officer for The Fertility Partners and a pioneer in reproductive medicine, was awarded The Lifetime Achievement Award at the 68th Canadian Fertility and Andrology Society (CFAS) Annual Meeting.

The Lifetime Achievement Award is a special recognition of an individual for extraordinary commitment and proven long-term contributions to the nonprofit CFAS and the field of reproductive science.

Referred to as the grandfather of in-vitro fertilization (IVF) in Canada, Dr. Yuzpe introduced new treatments, technologies, and procedures that revolutionized the field of fertility medicine in North America and worldwide.

We have always held tremendous respect for Dr. Yuzpes decades of experience and tireless commitment to improving fertility medicine, said Dr. Andrew Meikle, Founder and Chief Executive Officer of The Fertility Partners (TFP). The Lifetime Achievement Award from the CFAS is a great honor and well deserved. I know the entire TFP network is beyond proud to consider him part of the team.

Dr. Yuzpes research on hormones in the 1960s led to the development of clomiphene citrate and human menopausal gonadotropins and greater clinical understanding of follicle-stimulating hormone (FSH), some of the most commonly used drugs in fertility medicine today. In 1971 his work led to the development of an emergency contraceptive method using regularly available birth control pills, also referred to as the Yuzpe method.

Dr. Yuzpe was among the first physicians to bring laparoscopic surgery for infertility to North America after learning the technique from his Canadian colleague Dr. Jacques Rioux. In 1982 he founded one of the first IVF centers in Canada at the University of Western Ontario and brought to Canada the procedure of IVF developed by peers Dr. Robert Steptoe and Dr. Patrick Edwards, the U.K. physicians responsible for the worlds first IVF birth in 1978.

Dr. Yuzpe has consulted and advised IVF and infertility treatment physicians all over the world, and continues to advance the field of fertility medicine through his role with The Fertility Partners and as the co-founder and co-director of Olive Fertility Center in Vancouver.

Over the past few years, I have had the opportunity to develop a strong relationship with Dr. Al Yuzpe, said CFAS Executive Director Dr. Goldi Gill. Reflective of his knowledgeable and humble character, he is always willing to lend a helping hand to both me and the CFAS, an organization he has been an integral part of for so many years. I am thrilled that he is receiving this prestigious award, as it demonstrates his dedication to the CFAS, as well as the greater field of assisted reproductive technology (ART).

The CFAS is a multidisciplinary national non-profit Society that serves as the voice of reproductive specialists, scientists, and allied health professionals working in the field of Assisted Reproduction in Canada. Dr. Yuzpe, a former CFAS President, remains an active member of the society.

When I first began my career in obstetrics and gynecology in the 1970s, we didnt have very much to offer those who suffered from infertility, said Dr. Yuzpe. Now there is so much we can do. I feel fortunate to have worked with so many great minds over the years and to have been a part of the growth of fertility medicine. Thank you CFAS for the honor. Together, we have achieved great things.

Dr. Yuzpes contributions to education, research, and innovation greatly advanced fertility treatments that have helped patients worldwide build families. Today, more than eight million babies have been born from IVF.

Read more about Dr. Yuzpes contributions here.

About The Fertility Partners

The Fertility Partners is the business partner of choice for distinguished fertility practices across North America. With a network that includes 13 IVF centers across 36 locations in the U.S. and Canada, the Fertility Partners empowers leading fertility practices to achieve unparalleled patient experiences and outcomes through collaboration, strategic expertise and investment in people, process and technology.

For more information, please visit: http://www.thefertilitypartners.com.

See the rest here:
Pioneer in the Field of Reproductive Medicine Recognized - Business Wire

Mothers who stay at home have questioned why the Government is recognising their work by giving a tax credit to their spouses.

inance Minister Paschal Donohoe announced he was increasing the Home Carer Tax Credit by 100, to support stay-at-home parents.

The tax credit, previously worth 1,600, is available to couples who are married or in a civil partnership, where one of them is a full time carer.

The tax credit is applied to the earnings of the working partner.

So theyre going to recognise my work, by paying it to my spouse? said Ails N Chofaigh, a mother-of-one.

She said it was offensive that the Government was failing to value the work done by stay at home parents the vast majority of whom are women.

Its not income into my bank account, its not pay and its not recognition.

"Its a little bit insulting, to be honest. Is that what my work is valued at? A 100 tax credit, over the course of a year? Are you kidding me?

Ms N Chofaigh, who is based in Limerick and whose son is four-and-a-half, said it was offensive that the Government did not value the work of parents who cared for children at home.

In contrast it did appear to recognise the value of childcare outside of the home through its reduction in crche fees.

Stay-at-home parents work, we work hard. We just arent paid. We arent valued and we arent represented. And theres no way that isnt influenced by the fact that 98pcof stay-at-home parents in Ireland are women, she said.

What activist groups are there for us?

"What feminist groups?

Pauline OReilly, the Green Party senator and founder of Stay at Home Parents Ireland, said that there had been amazing supports for childcare costs announced in the Budget but she believed more needed to be done for stay-at-home parents.

The Governments plan to cut creche fees was hailed as a breakthrough for womens equality by the National Womens Council of Ireland, which said a lack of affordable childcare is the single biggest barrier to womens equality in the workplace.

Meanwhile, One Family, which represents single-parent families, saidthe increase of 12 for core social welfare paymentand a 2 additional payment for children will do nothing to mitigate against poverty in 2023.

A number of measures in Budget 2023 were aimed at easing the rising cost of living for women and families.

For the first time, IVF will be available on the public health service after funding was announced for the fertility treatmentwhich is currently only available through unregulated clinics, at significant expense.

The treatment will be available to couples who are finding it hard to conceive after a landmark assisted human reproduction bill makes its way through the Oireachtas.

The Government said that funding will be made available next year for a dedicated womens health package.

The recently launched free contraception scheme has also been extended from its original age limit of 17-25 to 16-30.

Free contraception for all women was first promised over four years ago. Hormone replacement therapy will now be subject to zero per cent Vat, as will mooncups, menstrual sponges and period pants. Products like tampons and sanitary pads were already subject to zero per cent Vat.

Read more:
Budget 2023: Stay-at-home mother blasts 'insulting' home carer credit rise - 'So they're going to recognise my work, by paying it to my spouse?' -...

Subterfuge has many faces, both facile and facetious. The Kuno National Park in Madhya Pradesh waited over twenty years to give an alternate home to the endangered Asiatic lions and found itself hosting the India- extinct cheetahs instead." The long wait is over. The Cheetahs have a home in India," said Prime Minister Narendra Modi referring to the Namibian feline, adding that "the experiment must not be allowed to fail".

The arrival of the eight radio-collared African cheetahs coincided with the 72nd birthday of Narendra Modi, who was personally present to release them into the park. If cheerleaders for the government termed it the return of the prodigal, critics called it the PM's vanity project.Be that as it may, to put the record straight, this is not the return of the prodigal - the Asiatic cheetah- who roamed the heart of India in large numbers in the days of yore. There are very few specimens of the Asiatic cheetah left, and they exist only in Iran, though, during the 16th century, 10,000 roamed the country, according to Emperor Akbar's chronicled accounts. The experimental release at Kuno by the PM is the African variant.

Explained | Factors that pushed cheetah, the docile cat, to extinction in India

"Cheetahs return to India after 70 years absence," ran international news headlines. This was not entirely true either, for it was during Modi's chief ministership of Gujarat that the state had brought two pairs of cheetahs from the Singapore zoo in exchange for an Asiatic lion and two lionesses. These were accommodated in the Sakkarbaug Zoo, the country's oldest such facility, in Junagadh on March 24, 2009, after a public function presided over by Modi himself." It is part of the state government's efforts to breed them successfully in the country," he had told the media on the sidelines of the event. The pair failed to mate till 2012, and a proposal for assisted reproduction under an expert embryologist could not be implemented because of their age. The two pairs died of natural causes after attaining the age of 12, the last one in 2017. Interestingly in the 1980s, a number of Indian zoos received the African cheetah from abroad, but efforts to breed them in captivity failed.

Published reports aver that the last three Asiatic cheetahs were hunted down in 1948, and four years later(1952), India officially declared the cheetah extinct in the country.

The UN World Wildlife Day official website states that cheetahs have vanished from approximately 90 per cent of their historic range in Africa and are extinct in Asia except for a single isolated population of perhaps 50 individuals in central Iran. Listed as 'vulnerable' by the International Union for Conservation of Nature(IUCN) Red list of Threatened Species and considered critically endangered in North Africa and Asia. Thus the planet's fastest land animal, also considered the least dangerous big cat, now stands reduced to about 7100 in the wild and the Asiatic cheetah to a mere 50. A century ago, there were one lakh cheetahs, points out the World Atlas.

The cheetahs are divided into four sub-species: the Southeast African cheetah, the Northeast African cheetah, the Northwest African cheetah and the rare Asiatic cheetah. African and Asiatic cheetahs diverged about 67,000 years ago, each evolving differently. The Asiatic feline is slightly smaller and slender than the African one, with a smaller and longer neck and legs and lesser weight.

It was the Congress-led UPA government headed by Manmohan Singh that established the project cheetah in 2009 and initiated efforts to revive its population in India by bringing in African Cheetahs. Site surveys conducted by global experts and government officials in the cheetah ranges of yore led to the selection of Kuno-Palpur in Madhya Pradesh. However, matters ground to a halt in 2013 when the Supreme Court hauled the Union ministry of forests and climate change (MOEFCC) over the coals for the plan to introduce the African cheetah into India, noting that Kuno-Palpur was not a historical habitat for this foreign feline and also for not initiating a detailed scientific study before doing so. The apex court quashed the order of the MOEFF, holding that it did not stand up to judicial scrutiny.

Thereafter in 2020, the National Tiger Conservation Authority approached the apex court with a plea for the experimental introduction of cheetahs in India in a carefully chosen habitat. The court relented but appointed an expert committee to decide on the viability of introducing the cheetah. The panel comprised M K Ranjitsinh, former director of wildlife preservation, Dhananjai Mohan, chief conservator of forests (Uttarakhand) and director general (wildlife). The Indian government released a cheetah action plan in 2021, and lo and behold, the first batch of the feline is here, with more to follow soon.

The expert committee's report assessing the potential for reintroducing the cheetah had recommended Shahgarh as its first choice, with Kuno-Palpur only as the second choice. It states, "based on the overall assessment inclusive of prey densities, human pressures and potential for conflict, we rate the surveyed sites in the following order for cheetah re-introduction.

1. Shahgarh: This landscape on the international border in the Jaisalmer district of Rajasthan was found to be suitable for introducing cheetah. Taking all aspects into account, this is the most appropriate sight, provided the area is enclosed by the proposed fencing, and the livestock is excluded. As the area is fenced along the international border, we propose to additionally fence off the bulge area by constructing another 140 km long chain-link fence to encompass about 4000 sq km of xerophytic habitat. Within this area, about 80 seasonally used human settlements, each having 5-10 households, would need to be relocated with adequate and generous compensation and alternate arrangements provided. Though the prey species diversity was less (primarily chinkara) in Shahgarh, the area could currently support about 15 cheetahs and had the potential to sustain 40 cheetahs with habitat management within the large fenced ecosystem.

2. Kuno-Palpur wildlife sanctuary in Madhya Pradesh was the second choice. Being readied for the lions for nearly two decades, the site was therefore found to be ready to receive a large carnivore. "We rate this second only for its smaller size. The buffer area requires inputs of relocation, enforcement and eco-development."

3. Nauradehi Wildlife Sanctuary has been rated third despite its very high potential as substantial investment and time required to make the 700 sq km inviolate by relocating 21 villages. The report warned re-introduction effort takes time, often with several failed attempts. "We envisage periodic bringing in of cheetahs to stock the sites for the next 15 years. After this time, resources will be needed to manage the established populations and their habitats. Long-term commitment of intent and resources are required for the program to be successful," it noted.

(The author is a senior journalist based in Ahmedabad)

Disclaimer: The views expressed above are the author's own. They do not necessarily reflect the views of DH.

More:
The genesis of the cheetah relocation - Deccan Herald