Amniotic Fluid Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2018 – 2026 – Market Research Correspondent

With having published myriads of reports, PMR imparts its stalwartness to clients existing all over the globe. Our dedicated team of experts deliver reports with accurate data extracted from trusted sources. We ride the wave of digitalization facilitate clients with the changing trends in various industries, regions and consumers. As customer satisfaction is our top priority, our analysts are available 24/7 to provide tailored business solutions to the clients.

In this new business intelligence report, PMR serves a platter of market forecast, structure, potential, and socioeconomic impacts associated with the global Amniotic Fluid Stem Cell Therapy market. With Porters Five Forces and DROT analyses, the research study incorporates a comprehensive evaluation of the positive and negative factors, as well as the opportunities regarding the Amniotic Fluid Stem Cell Therapy market.

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The Amniotic Fluid Stem Cell Therapy market report has been fragmented into important regions that showcase worthwhile growth to the vendors Region 1 (Country 1, Country 2), region 2 (Country 1, Country 2) and region 3 (Country 1, Country 2). Each geographic segment has been assessed based on supply-demand status, distribution, and pricing. Further, the study provides information about the local distributors with which the market players could create collaborations in a bid to sustain production footprint.

key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

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Amniotic Fluid Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2018 - 2026 - Market Research Correspondent

Mesoblast sees lasting need for COVID treatment beyond a vaccine – Sydney Morning Herald

Mesoblast is hoping its flagship product remestemcel-L will be shown to relieve acute respiratory distress syndrome (ARDS) in COVID-19 patients. The company is running a phase 3 trial of the product in US hospitals, but the research is still in its early stages, with a pilot study of the project looking at only 12 patients.

The US Data Safety Monitoring board, which reviews clinical data, had selected a date in early September to complete an initial review of Mesoblast's phase 3 trial, the company said. There are no approved treatments for this kind of respiratory distress, and it is not yet known whether its product will prove safe and effective in a large group of patients.

Dr Itescu said the company would know the results by the end of this calendar year. If the project is successful, the product could be manufactured in Australia for export into global markets to treat COVID patients around the world.

"We're tracking pretty much as expected," Dr Itescu said.

The company has also been working on getting the same product approved in the US for use in children who have graft-vs-host disease, a complication from bone marrow transplants.

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The Food and Drug Administration will review data about the effectiveness of the treatment on August 13. Dr Itescu said the regulator would advise whether the product has received approval before September 30.

Reviews of these two projects could have large implications for Mesoblast's future.

The company, which has been backed by high-profile investors including billionaire Alex Waislitz, has seen its shares turbocharged by updates on its COVID research in recent months. They jumped more than 5 per cent again on Thursday, trading at $3.84 by mid-afternoon.

The business generated $US2.1 million from customers in the June quarter and had $19.6 million in operating expenses.

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Mesoblast sees lasting need for COVID treatment beyond a vaccine - Sydney Morning Herald

Limited Reporting of Adverse Events Tied to Regenerative Treatments Leaves Consumers Vulnerable – The Pew Charitable Trusts

Editor's note: This was updated on July 31, 2020 to clarify when FDAs regulatory framework for regenerative medicine products takes effect.

The Food and Drug Administration (FDA) has taken a series of actions in recent years to crack down on businesses marketing high-risk, unapproved regenerative medicine interventions, including unproven stem cell treatments, but more needs to be done to ensure consumers are protected.

The proliferation of clinics offering these interventionsmore than 700 in the United Statesposes a significant risk to public health and has led to multiple instances of patient harm, including blindness and life-threatening infections. Although FDAs efforts so far are encouraging, additional steps can be taken to fully address the risks posed by businesses marketing these products.

In particular, better reporting by patients and physicians of adverse events caused by unapproved stem cell interventions will help FDA and other regulatory authorities identify the riskiest practices and take targeted action to protect patients.

In June, FDA sent a warning letter to Las Vegas-based EUCYT Laboratories LLC for marketing a range of unapproved regenerative products derived from umbilical cord blood, amniotic fluid, and other human cells and tissues. The company said the products could treat or prevent various diseases and conditions, including COVID-19.

According to the letter, one of the companys exosome products caused multiple serious adverse events in patients in Nebraska late last year, including severe infections requiring hospitalization. Exosomes are small, membrane-enclosed vesicles, or packages, of materials released by individual cells. They are thought to play a role in cell communication or molecule transmission. Researchers are studying them for a variety of potential clinical applications, but FDA has not yet approved any exosome products.

Other companies also have marketed unapproved exosomes to patients. Last December, the agency issued a general safety alert, noting that multiple clinics that manufactured or marketed illegal stem cell products had begun offering exosome treatments and warning the public that these approaches had not been evaluated for safety or efficacy. FDA then wrote to another firm, Kimera Labs in Miramar, Florida, noting that the company had been marketing exosomes to treat diseases or conditions such as Parkinsons, multiple sclerosis, brain injuries, diabetes, stroke, and spinal cord injuries.

Such efforts to enforce regulations for businesses marketing potentially dangerous interventions will likely expand significantly next year, when the agencys regulatory framework for regenerative medicine products takes full effect. In 2017, FDA released four guidance documents to clarify how it would regulate this burgeoning field and more clearly delineate which products must be reviewed before they go on the market.

At the same time, the agency granted businesses three years of enforcement discretion to give manufacturers time to comply with the new regulatory policy and begin moving their products through the review process. During this periodwhich was slated to end in November but has been extended for six months because of the COVID-19 pandemicFDA has taken a risk-based approach to enforcement, acting only against those products that pose a significant safety concern. Since 2017, the agency has filed injunctions against two companies and issued at least 35 regulatory letters to businesses marketing unapproved regenerative products.

Reports of patients being harmed prompted the agencys early actions. For example, in 2019, FDA and the Department of Justice sought and won a permanent injunction against a clinic that injected unproven stem cell products into three women suffering from age-related macular degeneration. The products blinded one and severely damaged the vision of the others.

Reports of such adverse events reach the agency through a variety of channels, including FDAs MedWatch database, which includes mandatory reports from manufacturers, suppliers, and distributors, as well as voluntary reports from physicians and consumers. Because many regenerative medicine products on the market are not FDA-approved, adverse events related to their use are likely to be reported only by patients and their physicians, and even then, only when those individuals know about the database.

This means that adverse events linked to unapproved regenerative products are underreported, perhaps significantly, making it difficult to know how widespread the harm is, or which businesses may be driving the problems. In general, adverse events for all medical products are underreported.

FDA acknowledged this challenge with regenerative therapies in a recent article in the Journal of the American Medical Association and encouraged more thorough reporting by patients and their clinicians. Improved reporting would allow the agency to target enforcement activities more effectively and reinforce the case for tighter regulation of this market. As awareness of the harms grows, fewer patients may be willing to undergo these treatments in the first place.

The agency should consider additional steps to encourage reporting. For example, although the number of consumer reports to the MedWatch database has increased in recent years, patient knowledge of the database appears to be limited. Targeted public awareness campaigns could help boost that knowledge and encourage broader use. The agency also could consider updating the instructions for patients in the MedWatch online reporting system to facilitate easier and more complete reporting of adverse events related to unapproved stem cell productsincluding essential information on where patients receive these treatments.

Most important, however, will be how effectively FDAand potentially otherregulatory authoritiesuse adverse event information to target enforcement activities. Once the period of enforcement discretion ends, the agency will need to take aggressive action against possibly hundreds of businesses across the countryincluding issuing warning letters and, where necessary, seizing products, filing injunctions or pursuing criminal prosecutions to stop the spread of these interventions and protect patients from harm.

Liz Richardson directs The Pew Charitable Trusts health care products project.

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Limited Reporting of Adverse Events Tied to Regenerative Treatments Leaves Consumers Vulnerable - The Pew Charitable Trusts

It’s Time to ‘Be The Match,’ Help Save a Life – SCVNEWS.com

Be the Match: Every three minutes, someone is diagnosed with a life-threatening blood cancer or blood disease, such as leukemia, lymphoma or sickle cell disease, and you might be able to help.

For those thousands, a cure exists, though about 70% of patients dont find it within their own families.

Thats why the College of the Canyons Biology Club is partnering with Be The Match to host a drive-in community registry event, where the community is invited to register to be a potential match for someone in need of a life-saving stem cell transplant through a simple swab test.

The science of stem cells is incredible, and it can actually cure over 70 different life-threatening diseases, said Christine Mantilla, member engagement, enrollment and experience specialist at Be The Match. A small population of stem cells from a donor can regenerate an entire bodys worth of bone marrow.

Biology Club President Brian Estarella-Murphy has been on the registry for two years, eagerly awaiting the day hes a match.

For Estarella-Murphy, its personal, as he has had two close friends with blood disorders and has seen firsthand the struggle of some of these patients.

I interned and shadowed at a hospital and a clinic, he added. Ive seen many patients come in that are on their last chance of life, and Id love to be able to give someone that possibility of living their full life without having to worry.

Being involved with the organization has actually changed his career aspirations, motivating him to go into the research side of medicine.

Im a cellular biology major, and the type of research that they do on these swab tests are exactly what I want to do in the future, he added. I want to pick apart these cells to see how I can help advance medicine (to create) life-saving treatment.

So upon taking up presidency of the club, Estarella-Murphy knew the first thing he wanted to do was partner with Be The Match.

Not only has the current health crisis been an extremely difficult time for those in need of transplants, as they are immunocompromised, but without community registry events, less have been joining.

This is an action that people can take in 10 minutes for free that can directly save someones life, Mantilla said.

Those interested in being a possible match, can drive up to the event from the safety of their car, where volunteers assist them in registering and administering the 10-second swab test on the inner cheeks while following all health and safety measures.

Were just doing a quick, little swab, and then we send your data out, and we do some research to see if youre possibly even a match, Estarella-Murphy said. Our goal out of this event is to sign up as many individuals as possible, so that through further research, we can then match them to patients awaiting dire transfusions.

Only about 1-in-430 U.S. registry members go on to donate bone marrow or peripheral blood stem cells to a patient.

Thats 0.2% and just emphasizes the need for as many people as possible to be available on the registry because it is so challenging to find that match, Mantilla said, adding that not everyone has an equal chance at finding a match, as ethnic heritage plays a significant role. Right now, the registry is overwhelmingly white. Its a health disparity that is pretty serious as far as equity of access to treatment.

The most common way to harvest stem cells is through a peripheral blood stem cell donation, involving a specialized blood draw, where stem cells are processed from your blood before the blood is returned to the donor.

Your stem cells are a renewable resource, so the donors stem cells actually regenerate in about four to six weeks, Mantilla added.

The event is scheduled 2-6 p.m. Aug. 14, with the location to be determined. For more information, visit biologyclubcoc.org/bethematch. To join the registry, visit join.bethematch.org/COCBio or text COCBio to 61474.

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It's Time to 'Be The Match,' Help Save a Life - SCVNEWS.com

Migrant workers and remittances in the context of COVID-19 in sub-Saharan Africa – July 2020 – World – ReliefWeb

MAIN MESSAGES

African migrants stimulate economic growth and development in areas of destination, transit and origin through their labour, skills transfer, consumption and investments. Their remittances also make significant contributions to food security, human capital, rural development and overall Gross Domestic Product (GDP) in areas of origin.

The impact of COVID-19 affects migrant workers disproportionally. Often precarious working conditions and overcrowded living and transport arrangements increase their vulnerability to contagion and loss of employment, threatening their health and livelihoods. Those working under informal arrangements, commonly in the agriculture sector, are largely excluded from accessing real-time reliable information, social protection, healthcare and government response measures.

Urban-to-rural return migration increases due to lockdowns and job losses in cities. This context poses challenges and opportunities in rural sectors, while many return migrants face stigmatization as potential carriers of the virus.

A 23 percent decline in remittances flow into sub-Saharan Africa (SSA), as a result of economic downturns, restrictions in movement and challenges sending transfers to SSA, is expected to heavily impact the livelihoods of households and countries that rely on them for food and other basic expenditures, such as health and education.

The safe movement of workers in the agrifood system within and between countries should be facilitated, recognizing their vital contribution to food security. To this end, occupational safety and health measures should be put in place in the workplace, housing and transportation means, working visas extended, and temporary work permits conceded.

The inclusion of migrants, regardless of their work or migratory status, in COVID-19 socioeconomic impact assessments, response and recovery plans (including social protection programmes) will reduce the risk of transmission for the entire population while safeguarding the livelihoods of many households falling into poverty as a result of the pandemic. The leave no one behind approach takes a public-health dimension in addition to a human-rights one.

Coordinated, multisectoral and multilevel responses that are migrant-sensitive in their design and include the perspective of migrant associations and diaspora, in addition to responses from governments, the private sector and producer organizations, should be developed in the region to ensure sustainable policies that go beyond the crisis and build back better. Such interventions should be gender-sensitive and tailored to specific country contexts (For aglobal analysis see: FAO. 2020. Migrant workers and the COVID-19 pandemic.)

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Migrant workers and remittances in the context of COVID-19 in sub-Saharan Africa - July 2020 - World - ReliefWeb

Letter to the editor: Anger exploits our free speech – Huntington Herald Dispatch

Hate speech inflicts damage. Jokes about the prophet Mohammad kindles death threats and assassinations. Threatening POTUS with harm assures jail time. Yelling a false alarm in crowded venues initiates stampedes resulting in injury and potentially death of those trampled. Verbal abuse of children shatters their self-esteem and distorts their world view. Exhibitions of wrath herald subsequent destructive ramifications.

About a year ago, DW News constantly called President Trump the Twitter in Chief. On Twitter, Donald Trump sought to block any critics following him. In March, the appeals court ruled that Trump could not block his critics. Blocking critics from following his account being employed as a public forum was ruled as unconstitutional under the First Amendment. This issue has slowly inched toward SCOTUS consideration. In May, Twitter required that users read a notice before viewing Trumps tweet. His tweet warned retribution for the actions of George Floyd protesters in Minnesota. Twitter asserted that he violated its policy of glorifying violence. Subsequently, the president issued an executive order using Section 230 of the Communications Decency Act (liability protection for contents of posts), wherein Trump accused Twitter of violating his freedom of speech. In June, Twitter deleted a racist baby video posted by the president. This tug-of-war dynamic has revealed angers exploitation of free speech.

Twitters approach of labeling inflammatory speech initially appears reasonable. Yet, questions linger about the methods for evaluating errant posts. Perhaps transparency and adjudication offer a solution. The demand exists not to eliminate but to flag hate speech, misinformation and half-truth in the media, especially during this falls election. Sren Kierkegaard proposes a cause for the current situation, People demand freedom of speech as a compensation for the freedom of thought which they seldom use.

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Letter to the editor: Anger exploits our free speech - Huntington Herald Dispatch

Live-Streaming Service Twitch Gives Subscribers 10% Discount if They Pay With Cryptocurrency – Bitcoin News

The live-streaming service Twitch is now offering a 10% subscription discount for people who register with cryptocurrency. The new offer from Twitch leverages the Bitpay payment processor, as this is the first crypto-based discount promotion from a company of this magnitude.

This week, the live-streaming service Twitch revealed it is offering a 10% discount for subscribers who pay for subscriptions with a cryptocurrency. Twitch is a service that allows live streaming and it was introduced in 2011.

The platform is most popular among live-streaming gamers, and in 2017 it outpaced the streaming service Youtube Gaming. Twitch has over 27,000 partner channels, 15 million daily active users, and 2.2 million broadcasters monthly.

In order to allow people to leverage cryptocurrencies for a 10% discount on services, Twitch, a subsidiary of Amazon, is utilizing Bitpays crypto processing system to accept payments.

The Atlanta-based company Bitpay allows payments in bitcoin (BTC), bitcoin cash (BCH), ethereum (ETH), four USD-pegged stablecoins (GUSD, USDC, PAX, and BUSD), and ripple (XRP). Being a Twitch subscriber, users have exclusive access to emotes, badges, and the ability to follow their favorite streamers regularly.

According to Bill Zielke, Bitpays chief marketing officer Twitch is the first major merchant to jump on this trend. Twitch is not the only gaming website and live streaming service that offers cryptocurrency support.

A number of gaming firms like Take Two (Disintegration and Outer World) and Microsoft support cryptocurrency payments. In order to get the 10% discount individuals interested in registering for a Twitch subscription simply select pay with Bitpay at checkout in order to pay with a digital asset.

Bitpay explained that it is thrilling to see a trendsetting firm like Twitch accept cryptocurrencies. The Atlanta firm believes that the gaming industry specifically goes hand and hand with crypto asset support. Just recently Bitpay published a blog post that shows online gaming operators attract players using Bitpay for instant bitcoin deposits.

The company notes that crypto acceptance adds potential to expand a user base, it lowers costs, eliminates chargebacks, offers speed, and is borderless, as bitcoin (BTC) and other crypto assets can be sent anywhere in the world in minutes, the company highlights.

What do you think about Twitch offering a 10% discount for people who pay with crypto? Let us know what you think in the comments below.

Image Credits: Shutterstock, Pixabay, Wiki Commons, Bitpay

Disclaimer: This article is for informational purposes only. It is not a direct offer or solicitation of an offer to buy or sell, or a recommendation or endorsement of any products, services, or companies. Bitcoin.com does not provide investment, tax, legal, or accounting advice. Neither the company nor the author is responsible, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of or reliance on any content, goods or services mentioned in this article.

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Live-Streaming Service Twitch Gives Subscribers 10% Discount if They Pay With Cryptocurrency - Bitcoin News

Ripple has released 1 billion XRP; here’s what this means – Nairametrics

Ethereum (ETH), the worlds second most valuable cryptocurrency, has more than tripled in value over the last four months. This indicates that Investors are increasingly raising their stakes in the fast-growing crypto-asset.

As at 5.00 am GMT, Ethereum was trading around $405, a 361.6% gain since March 12th, 2020, when it traded at $112. Its market capitalization presently stands at $45.3 billion.

Ethereum is the second most valuable cryptocurrency, as it now has a market capitalization of $43.23 billion.

READ ALSO: Fastest growing cryptocurrency, Compound (COMP) up over 143% in 24 hours

What could be the reason for Ethereums rise?

Kelvin Koh, the co-founder of a venture capital Spartan Black, gave an insight on what could be responsible for such surge in the ETH market. He said:

The strong move in Ethereum has to do with the upcoming ETH 2.0 launch which is a major catalyst. Every phase of ETH 2.0 over the next 2-3 years brings ETH closer to its final state and will be catalysts for Ethereum.

READ ALSO: Dogecoin gains 50% in less than 24 hours, highest single-day gain since 2017

What you should know about Ethereum: ETH is a cryptocurrency designed for decentralized applications and deployment of smart contracts, which are created and operated without any fraud, interruption, control, or interference from a third party.

Ethereum is a decentralized system, fully independent, and is not under anybodys authority. It has no pivotal point, and its platform is connected to thousands of its users through their computing system around the world, which means its almost impossible for ETH to go offline.

READ MORE: XRP losing steam as BTC & ETH gain investors funds

Meanwhile, ETH miners are having a field day, recording the highest revenue levels (in USD) since Q3 2018. The % of the revenue that currently comes from fees is in a league of its own. The average is between April 2018 to April 2019 and was 3%.

In July, 22.2% of Ethereum miner revenue came from transaction fees. This is the highest monthly value in ETH history and is a continuation of the sharp upwards trend in the past three months.

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Ripple has released 1 billion XRP; here's what this means - Nairametrics

Abbott, Liberal Party at odds over voting problems ahead of Monday’s convention – CBC.ca

Liberal leadership hopeful John Abbott and the Liberal Party of Newfoundland and Labrador are at odds over how prevalent voting problems are, only three days before the virtual convention that will decide a new leader.

In a media release issued Friday afternoon, Abbott said the party shouldextend the deadline to cast a ballot.

"We are concerned about the votingsystem that the Liberal party is conducting," Abbott told CBC News in an interview shortly after his media release.

Abbott is competing for the job against Andrew Furey, an orthopedic surgeon. The virtual convention to decide the party's next leader, and also premier of the province, is scheduled for Monday.

Specifically, Abbottsaid his campaign staff have heard that registered voters still don't have theirPINs, which are needed to vote. Some are still waiting to get them via email and via the mail,Abbott said. He said because of that,the party should consider extendingthe voting deadline.

"We work from the premise that every registeredvoter has the opportunity, and should have the opportunity to vote. And if there is a delay on behalf of the party, then the voters should not have their vote, potential vote, discounted," he said Friday.

Abbott said the voter helpline that is supposed to help sort these issues out for people, including instructions on how to vote, is "constantly busy" because it's understaffed.

In a statement sent Friday afternoon, Furey's campaign said, "We are hearing from some supporters that they have successfully called the voter helpline to obtain their PIN and were then able to vote. In some cases, supporters have chosen to leave a message with the help centre, and in other cases supporters have chosen to call back at a later time. We continue to offer whatever support we can to registered voters, and understand they are successfully voting throughout the process."

The Liberal Party disagrees with Abbott's portrayal of a problem-plagued voting system, saying the issues he is raising "are isolated, expectedand are being addressed as they arise," according to a statement from Michael King, the party's executive director.

"We have full confidence in the integrity of this process. Both campaigns are on a level playing field," he wrote.

King said more than 15,000 people have already voted out of about 34,000 registered voters.

King said the party is aware that some emails, containing PINs, have bounced back, but, he said, that "is likely due to either a typo from when voters entered their email address when they registered or a data entry issue on the part of either campaign."

Both campaigns have been provided a list of people affected by the bounce-backs so they can follow up with them.

King admitted the helpline was "initially very busy" but said extra staff have been added.

"That process is now working smoothly with plenty of time to vote," King said in the statement.

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Abbott, Liberal Party at odds over voting problems ahead of Monday's convention - CBC.ca

On race and liberalism – Letters to the editor | Letters – The Economist

Aug 1st 2020

Letters are welcome via e-mail to letters@economist.com

The Economist missed the point about the Black Lives Matter movement (The new ideology of race, July 11th). You praised Martin Luther Kings vigorous protest and relentless argument, but criticised the methods of todays activists as dangerous, contending that they seek to impose their ideology through intimidation and power. King may have taken issue with your position. In his Letter from Birmingham Jail, written in 1963, King wrote:

I must confess that over the past few years I have been gravely disappointed with the white moderatewho is more devoted to order than to justice; who prefers a negative peace which is the absence of tension to a positive peace which is the presence of justice; who constantly says I agree with you in the goal you seek, but I cant agree with your methods of direct action; who paternalistically feels he can set the timetable for another mans freedom; who lives by the myth of time and who constantly advises the Negro to wait until a more convenient season.

While todays activists should be open to constructive criticism, this is not the most important issue at hand. The Economists line makes clear that it is more interested in maintaining comfort and economic stability rather than achieving change. Its words perpetuate white complacency.

GRIFFIN CONGDONNew Haven, Connecticut

Your leader dripped with establishment anxiety over the growing influence of Black Lives Matter and the broader progressive movement. It reeked of the classic you-cant-say-anything-these-days terror that radiates off those whose intellectual authority is being challenged. Rashad Robinson, president of Colour of Change, perfectly summarises this type of miscalculation: Far too often we mistake presence, visibility and awareness for power. Disappointingly, The Economist fell into this trap, equating the visibility of anti-racist voices in the virtual public sphere with the economic, political and judicial heft of the systems they seek to reform, dismantle and democratise. This false equivalence would be laughable if it wasnt so insulting.

A. MENSAHLondon

* The new ideology of race? The old has never ended. It has been embedded in Anglo-Saxon thinking for centuries. It has justified the invasion and land theft of todays America, Canada, Australia and New Zealand. That land was occupied and owned by Aborigine states, and to clear it, the Anglo-Saxon colonists simply invaded, stole and killed off the Aborigines. Then a whites only policy was instituted and turned into law, such as the Chinese exclusion acts of the early 1900s, and lasted, with Jim Crow laws, into the 1970s. Not to exclude the long-term use of slaves.

So what is new? The draconian suppression of black demonstrators, the exclusion of a growing China, making illegal Chinese advanced technologies that are superior to American ones. Same racial animus, same racial ideology. Only described differently.

HENDRIK WEILERPort Perry, Canada

Although liberalism has given the world theoretically unassailable values such as free speech, it has not been as successful dealing with pervasive social problems. The liberal state of nature and veil of ignorance imagine a society untarnished by politics. Thomas Hobbes, John Locke, and even John Rawls claimed to have established that the equality of mankind was determined by our fear of slaughtering each other, God, or rationality.

No one who studies political philosophy takes this exercise in apolitical history at face value. Their conclusions about government are based on a flawed assumption that humans once lived without politics. Social order has always existed, and therefore, so has politics. The assertion that all men are created equal is based on Enlightenment principles that were primarily created to check the power of government and protect property rights. The pursuit of these goals made it possible to ignore social inequality in general and allowed for the hypocrisy of most of the Founding Fathers owning slaves.

As you pointed out, liberal thinkers have always struggled with conceptualising unequal power relationships among groups. Critical theorists, their roots based in Marxism, inevitably face similar challenges when arguments are premised on simplified assumptions. If racism and discrimination are systemic, where do they originate from? Why do they persist, even if no one at an institution holds racist beliefs? And, hardest of all, what about individual rights?

However, it is liberalism that has had centuries to deal with prejudice and the social ills it produces. Thus far, the solutions it has offered are inadequate.

HEATHER KATZAssistant professor of political scienceSouthwestern Oklahoma State UniversityWeatherford, Oklahoma

* What is the point of a theory of justice that is silent on how the actual world is ravaged by injustice? My own view: properly applied, John Rawls clears away the whataboutery and wonkishness to expose our persistent racism as a stunning, continuing injustice. A nail may want a hammer, but we need a lamp to see our work.

V.VM.SCARPATO IIIDenver

* You lamented the disempowerment of individualism. However, American slavery and subsequent institutional oppression did not operate on an individual basis, but by the desire to keep an entire group of people disenfranchised and powerless. Hence, it is impossible to uproot this mentality from the American way of life. Black people decry daily their inability to carry on simply as individuals, a privilege only afforded to white people. But they do recognise that the institutions that shape their lives are fundamentally biased against their group. Data show significant inequalities between the races, and much of black culture has developed as a direct consequence of these inequalities. How can one begin to remedy such differences without considering the historical and ongoing group dynamics?

The truth is that a black person can have individual freedom and the pursuit of happiness only if African-Americans as a group have freedom and the pursuit of happiness. If liberalism cannot incorporate such a moderate idea, perhaps it is time to rethink how progress should be achieved, to dare suggest that another system can give America the life expectancy, material wealth, poverty, literacy, civil rights and rule of law for which you credit liberalism, in addition to the racial equality that has eluded it so far.

PATRICK NTWARIBoston

* The implicit bias trainings I have attended awakened a notion that we all have a demon inside us that distrusts the different borne of millennia of seeking survival and self-defence. This demon cannot be wished away. Instead, focus on what we control and judge accordingly.

Do we really want to be judged for differences we have no control over? It was Martin Luther King who dreamed of the day when his children will live in a country where they will not be judged by the colour of their skin, but by the content of their character. No human being has a choice about which body to be born into. Prejudice on this basis is patently illogical. Rainbow flags and gay-pride parades herald the type differences we do not control. Focus on the important quality we do control, which is our character. May our character exude kindness rather than malevolence.

PETER ROBERTSSeattle

* Imagine a United States where every head of a household with children had a decent full-time job with health insurance. Add this to The Economists good ideas about housing and early childhood (Staying apart, July 11th) and few American children of any race would go hungry or suffer the other ills of desperate poverty. Single mothers would not be exploited in jobs with terrible schedules and working conditions. Todays daunting choice between fighting the coronavirus and creating jobs would be lessened.

More than 40 years ago, President Jimmy Carter introduced the Better Jobs and Incomes Programme. It would have federally financed community jobs to bring about this vision. There are challenges. Meaningful jobs and apprenticeships would need to be created in sectors such as health, energy and the environment. Legislation would have to address geographic differences in the cost of living, unions would have to co-operate, and more. But the challenges are solvable and the benefits substantial.

ARNOLD PACKERFormer assistant secretary of labour in the Carter administration.La Jolla, California

In Who We Are and How We Got Here, David Reich, a population geneticist, related the story of how a piece of his research that identified genetic variants associated with an elevated risk of prostate cancer among men of west African descent led to accusations from some of his colleagues that he was flirting with racism. Critical race theory does not allow for the possibility that racial disparities in health could be caused by something other than systemic racism. If accepted, its assumptions make it nearly impossible to eliminate any racial disparities that have other causes, because the type of intervention required to address a disparity depends on what the disparity is caused by.

JONATHAN KANEFlat Rock, North Carolina

You made a good case for a genuinely liberal approach to race, at a time when the modern left has forgotten what a truly liberal society is. You see what we all see: intellectual rigidity and intolerance of dissent, the fomenting of division, racial obsession replacing colour-blind equality of opportunity, identity politics taking priority over the rights of the individual, all the marks of an authoritarian society, not a liberal one.

Donald Trumps speech at Mount Rushmore was an attempt to address this issue. You say his speech strived to inflame a culture war centred on race, when in fact he was expressing the very concerns you share.

STEVEN VAN DYCKToronto

Congratulations on having the courage to challenge the intellectual hogwash that is the new race and identity politics. Prejudice based on skin colour is among the idiotic of all prejudices and it must be challenged. But to go from there to the construction of a Marxist-derived analysis, this time with white people as the new group to hate instead of the bourgeoisie, is nonsense on stilts. Its intellectual dishonesty is imbued with a Manichean worldview and totalitarian instincts. George Orwell would recognise all the newly woke, self-haters of the academic and cultural elite, who have meekly caved-in to show trial by Twitter.

SIMON DIGGINSRickmansworth, Hertfordshire

* Critical race theory brings to mind one fundamental Marxist concept: that there is no objective truth and each class generates its own truth. Race ideology, just like Marxism, did not take a wrong turn. As somebody who was forced to study Marxism in a communist country, I see a perfect similarity: an ideology pushed by intellectuals with little contact with the real world, no compassion for real people, and fancy concepts leading to the most unfair and sinister consequences. Critical race theory leads by design to intolerance, the silencing of dissenters and polarisation.

ANDREI TUDORANHouston

The hard part of resolving Americas racial economic gap starts with facing the actual history of our country. When I attended high school in California in the 1980s, I learned nothing of the lynchings in the post-Reconstruction era, nor of the Tulsa massacre or other white riots, nor the redlining that prevented black Americans from building home equity. White Americans need to fully reckon with this betrayal of their fellow citizens.

MARK SEAMANNew York

* I fear a bigger problem for the future. I moved to North Carolina during a year when Jesse Helms was running for Senate. His main campaign ad was a set of white hands crumpling a rejection letter, the implication being that a qualified white did not get a job because of affirmative action to help blacks. We must be careful that in trying to improve black lives we do not once again turn it into a fight between blacks and lower-class whites, with rich whites laughing all the way to the bank. Just as in the 1920s the Northern Ireland government broke an attempt to create a united Protestant-Catholic union in the shipyards by promising all Protestants a job, so the people on top in America succeeded once in turning the racial issue into a fight within the lower class.

ALAN LANEAssociate professor of historyBarton CollegeWilson, North Carolina

* The greatest danger to liberalism is not the pantomime villains you boo each week, but rather the choking hypocrisy within its own ranks. Instead of basking in your enlightenment, as individuals you need to petition your local councils for more refugees and disadvantaged people to be housed and schooled in your own communities, whatever the effect on house prices. Stop tilting at Trumpian walls and Orbanite fences, and start addressing the far more formidable and discriminatory socioeconomic barriers that shield you from the adverse side effects of the globalisation and mass immigration that you piously prescribe for others.

ISTVAN SZABOLondon

* I object to your description of the street corner where George Floyd was murdered as shabby. In fact, it is home to several successful small businesses and is neither neglected nor unsafe. Our city has already been maligned enough because of recent events and this incorrect description was unnecessary.

THOM ROETHKEMinneapolis

One cannot easily shake off unwanted associations with partners picked up during a prolonged binge. As you made quite clear, liberalism awoke to find itself in bed with slave-traders and unbridled imperialists. Singing its prelapsarian virtues now, however sweet the tune, will not readily assuage the critics.

MATTHEW KAPSTEINDirector of studies, emeritusPractical School of Advanced StudiesParis

* Letters appear online and in app only

This article appeared in the Letters section of the print edition under the headline "On race and liberalism"

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On race and liberalism - Letters to the editor | Letters - The Economist

Medical Schools Have Historically Been Wrong on Race – The New York Times

A senior white physician stands by silently as a white patient uses a slur to describe a Black nurse.

A middle-aged doctor asks a Black student why the lower-income Black patients in the clinic arent able to speak and act the way she does.

Several young doctors make fun of Black-sounding names in a newborn unit and speculate when each infant will later enter the penal system.

Instances of racism like these are happening in medical schools across America today, just as they happened when I was a medical student 20 years ago.

I still vividly recall the afternoon many years ago when a patient angrily suggested that I go back to Africa and stay there, and the shrug that my white supervisor offered when I told him what happened. Ill also never forget when a Muslim students name was openly mocked by a senior doctor who questioned whether he was a terrorist. Nor will I forget the moments I saw Black patients intelligence, motivation and truthfulness derisively questioned.

Facing the power of those above us, I remember many of my peers and me putting our heads down, just enduring, on our way to becoming full-fledged doctors. The stings never faded.

Now, however, many future physicians of color and their white allies are doing what we were too afraid to do: They are speaking up and demanding change. And medical school leaders are being forced to listen to them. Medicine, like other institutions in society, is now being called to task by its own for the role it has played in perpetuating the longstanding inequities that have led us to this moment.

The conversation took on new energy at the start of the Covid-19 pandemic, which exposed racial health disparities dating back to the origins of our country. And it became inflamed in the aftermath of George Floyds video-recorded murder.

I see myself in all of the dimensions of this overdue conversation: I am the medical student facing discrimination, a Black man with pre-existing health conditions and a medical school professor forced to face the cold reality that I have not done nearly enough to help my patients or my students of color.

On so many levels, Black patients and Black doctors are perpetually fighting upstream. Covid-19 has killed Black people at a rate roughly two times greater than would be expected based on their share of the population. Still, diabetes, heart disease and many cancers have disproportionately ravaged Black families for much longer. Leading medical journals across all clinical specialties have chronicled these stark realities for years. But wide-scale interventions are scarce.

Racial health disparities cant change until the health system changes itself. Starting that transformation means shifting the way that medical students are taught the interplay between race and health. For far too long, medical schools have neglected to tackle the full complexity of race in their curriculums. And two problematic, longstanding prejudices have filled that vacuum and impeded progress.

One is the focus on race as a category signifying distinct biological difference, a belief that dates back to slavery, where it was used as justification to maintain the practice. Yes, Black people are much more likely to have sickle cell anemia, just as white people are more likely to have cystic fibrosis. But these and other diseases that closely, but not precisely, track with race (or more accurately, ethnic origin) represent a very small fraction of what is encountered in medicine.

Still, distinctly race-based biology remained mainstream medicine throughout much of the 20th century. And this allowed for some of medicines most egregious sins: As recently as the 1970s, Black people were experimented upon under the guise of scientific study and sterilized without their consent.

While those blatant horrors of the past are gone, the ideology that fueled those actions stubbornly lingers.

A 2016 study at one institution found that half of the medical students and residents surveyed agreed with one or more false statements about biological differences based on race, such as the idea that Black people had thicker skin and less sensitive nerve endings than their white counterparts.

The study only buttressed earlier surveys in which white physicians consistently categorized Black patients as less intelligent. Such false beliefs, left unchallenged, or worse, tacitly reinforced by professors, can lead a new generation of doctors to perpetuate discriminatory practices. To name just one example: Black patients are prescribed less pain medication for injuries comparable with those of their non-Black counterparts.

The other major flawed way in which medical education has historically been wrong on race is in its eagerness to ascribe health differences primarily to Black peoples supposed pathological misbehavior.

Too often, physicians assume certain groups of people bring an array of maladies or misfortunes upon themselves with intentional bad choices. During my residency training in psychiatry, a doctor I worked with suggested that Black men were more likely to have poor judgment (excluding me of course, he quickly added) and that this explained why they faced higher rates of involuntary hospitalization and the potentially negative consequences that come from it.

The overlapping prejudices embedded in the medical establishment are ultimately harmful not because they hurt feelings but because they alienate patients who need help and lead to bad medicine. They are biases that prevent the profession from taking a more accurate and enlightened view that emphasizes the pervasive environmental and economic roots of patients health problems.

Covid-19 has highlighted these issues. Pathologizing Black behavior leads to blaming Black patients, like the theory of an Ohio physician and politician who publicly speculated last month whether Black people are more susceptible to Covid-19 because they dont wash their hands enough.

A more nuanced approach, informed by public health, leads to exploring the real, underlying reasons the coronavirus has caused more destruction in Black communities: crowded multigenerational housing arrangements, more frequent use of public transportation and employment in newly hazardous front-line service jobs.

In recent years, many medical schools have begun broadening curriculums to include implicit bias and the social factors that influence the health of diverse patient groups. But even the most dynamic lecture can be easily drowned out by the hundreds of hours students spend experiencing the broader informal curriculum in clinics and hospital, where myths about biological difference and behavioral pathology still linger.

So its essential that we set up ways to ensure physician-educators are also trained and periodically evaluated in a tangible and accountable way. That way they can pass along a more empathic and open-minded approach to treating patients. And its a task too important to be relegated to a certain lecture or delegated to Black faculty. If it doesnt involve every component of the medical school, we will continue to perpetuate the problem.

Thanks to the work of brave young medical students who have pushed us to have this introspective discourse and re-examine our practices, medicine is being presented with an opportunity to reckon with its troubled past and redefine its societal role.

A profession sworn to heal can no longer passively accept the inequities it has witnessed for decades or the hand that it has played in them.

Damon Tweedy is an associate professor of psychiatry at Duke University School of Medicine and the author of Black Man in a White Coat: A Doctors Reflections on Race and Medicine.

The Times is committed to publishing a diversity of letters to the editor. Wed like to hear what you think about this or any of our articles. Here are some tips. And heres our email: letters@nytimes.com.

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Medical Schools Have Historically Been Wrong on Race - The New York Times

From poker pro to slaying victim: Susie Q’s unlikely story – The Detroit News

White Lake Township The mystery over the slaying of a professional poker player in July remains, even as friends and family welcomed news of an arrestin the case.

While preparinga memorial honoring the life of a talented, high-stakes player, they cautiously embraced the news. But they're bracingto learn the truth about the death of Susie Zhao, 33.

This is a horrendous thing that has happened, said Kinga Wierzbicka, a friend since middle school. Its amplified because we have no answers.

Police said Sunday a60-year-old Pontiac man has been arrested in connection with the death of the professional poker player from Waterford Township.

The man was taken into custody about 9 a.m. Friday after his vehicle was stopped near an area freeway, according to White Lake Township police.No charges have been filed and no other details were released.

Susie Zhao(Photo: White Lake Township Police Department)

Zhao had recently returned from Los Angeles to live with family in Waterford Township.

Her body was found at about 8:05 a.m.along the edge ofthe Pontiac Lake Recreation Area,clad in jogging pants and other clothing, lying in a parking area on Maceday Lake and Cross roads in White Lake Township, police reported.

A Michigan Department of Natural Resources worker last checked that area around 11:45 p.m. the night before, said Detective Lt. Chris Hild of the White Lake Township Police Department.

Hild has said her death could be related to her travels on the poker circuit.

For her friends, the loss of someone so lively and with no likely enemiesis difficult to fathom.

I dont think Im ever going to stop thinking about it. Its not something you can let go of, saidMichelle Lagrou, a friend since high school.

Zhaos close social circle is workingto ensure the fun-loving woman who once described herself online as a knowledge seeker/adventurer/Little hippie is not forgotten.

She did not deserve this, said Meredith Rogowski, a longtime friend. This is a horrible tragedy and I hope this doesnt define the life she lived.

Susie Zhao, pictured in 2017.(Photo: Facebook)

Those 33 years, they say, were anything but ordinary.

Immigrating from China as a child, Zhao,known as Susie Q,grew up in Troy and lived not far from Somerset Collection, her friends said.

After middle school, she attended Cranbrook Schools in Bloomfield Hills, then Northwestern University in Illinois, Wierzbicka said. According to Zhaos Facebook page, she studied psychology and business.

Gaining friends was easy for someone whose vibrant personality matched the colorful outfits she favored.

She just had a beautiful aura, Wierzbicka said. People loved her. She was just super bubbly. She had one of those personalities you wanted to be around.

Following successful poker sessions as a youth and online gaming in college, Zhao parlayed her playing prowess into a professional career, her friends said.

In time, she moved to the West Coast and graduated to competing in tournaments that earned her more than $150,000 between 2009 and 2017, according to a profile on the World Series of Poker website.

The website for Hendon Mob, touted as the largest live poker database, listed her winnings as more than $222,000,including $73,805 at an event in 2012.

Being able to quickly turn a little money into a big pot of money gave her the freedom to live life how she wanted, and she got a lot of satisfaction dominating in a mostly male profession, Rogowski said.

On a Twitter profile, Zhao described herself as being able to prance like a unicorn in a sea of horses. I proficiently play high stakes poker for a living. Its kinda weird because I'm a girl.

While a deftness at reading people and creative thinking made Zhao a formidable opponent, she inspired loyalty, said Yuval Bronshtein, a professional player who first mether during a competition more than a decade ago. Everybody liked her. Everybody rooted for her.

Clayton Fletcher, a comedian, remembers meeting her during the 2015 World Series of Poker main eventin Las Vegas when they played at the same table.

First prize was something like $8 million, but you wouldn't have known there was that much at stake from the atmosphere of joyful (camaraderie) at our table, he told The Detroit News.

Susie immediately got the party started by introducing herself to all her opponents, making silly jokes, and basically putting us all at ease with her great sense of humor and disarming smile. As a professional comedian, I really appreciated her style and attitude: buoyant and whimsical between hands, but focused and extremely competitive once the cards were dealt.

As Zhao rolled to success, she never lost touch with her Metro Detroit friends whether sending random texts or meeting up when returning to the region for holidays. The year several members of the group turned 30, she invited them to celebrate in Las Vegas,showing her super-generous nature, said Lagrou. She was never too big to care about us.

Zhao with Kinga Wierzbicka, left, in California, 2016.(Photo: Facebook)

On July 12, the last day she was seen alive, Lagrou said Zhao had just returned from a weekend trip up north, near Saginaw, with her and others.

Relatives last saw her at their home around 5:30 p.m., Hild said.

While awaiting results from an autopsy to determine the cause of death, investigators have been examining whether her poker background is related, Hild said. Were also looking into where she was and who she was with locally here in the few days prior to her death.

The FBI has also been investigating, said Special Agent Mara Schneider, public affairs officer for its Detroit office.

Although friends recall Zhao did not divulge some aspects of her life, they doubt she had enemies. I dont know anybody who might be mad at her, Bronshtein said.

Those who joined Zhao for New Years Eve parties and other festivities over the yearssavor their memories while also wrestling with a question about her death: why?

"We just want to know what happened," Lagrou said. Were trying to figure out for our own peace of mind."

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From poker pro to slaying victim: Susie Q's unlikely story - The Detroit News

Hugh Freyer, Poker Player With Discretion of a Banker, Dies at 86 – The New York Times

This obituary is part of a series about people who have died in the coronavirus pandemic. Read about others here.

Hugh P. Freyer played seven-card stud in the Bronx with a core group of fellow recovering alcoholics for more than 30 years. The discretion demanded by his day job as a private banker, combined with the self-discipline required by Alcoholics Anonymous, made him more prudent than most of those at the table.

He always had a budget when he played, and he did not play beyond his means, ever, his daughter, Carolyn Freyer-Jones, said.

His prudence, she recalled, extended beyond poker: He had no debt, he paid off any credit cards he used every month, and all of his end-of-life details were paid in advance, by him.

Mr. Freyer was admitted to a Bronx hospital on June 20 for blood pressure problems. He tested negative for the novel coronavirus, as he had a week earlier when he was examined by his own doctor.

But the day before he was scheduled to be released for rehabilitation, Ms. Freyer-Jones said, he tested positive. Nine days later, on July 14, he died at the hospital. It was his 86th birthday. She said the cause was complications of Covid-19.

Hugh Philip Freyer was born on July 14, 1934, in Manhattan, the son of Josephine (Shannon) Freyer, an Irish immigrant who worked as a cleaning person at New York Hospital (now NewYork-Presbyterian), and Hugh Freyer, a window washer who was born in South Africa.

Hugh was raised in the Washington Heights neighborhood and, after graduating from George Washington High School, served in the Army in Korea from 1957 to 1959 as a radio operator. He started working at what is now Citibank in 1959 and attended night classes at New York University, earning a bachelors degree in business in 1967.

He rose from branch manager to corporate vice president, then moved to the New York office of the London-based bank Standard Chartered, where he was a senior vice president until he retired in 2001 at 67.

As a member of Alcoholics Anonymous for more than 50 years, he counseled patients at Roosevelt Hospital (now Mount Sinai West) who had been admitted for drug and alcohol overdoses. He also served on A.A.s board.

He married Gertrude Flexer in 1956. They lived in the Riverdale section of the Bronx. She survives him. In addition to their daughter, he is also survived by their sons, Philip and Paul Freyer; seven grandchildren; and his sister, Kathleen Harmon.

The prudence Mr. Freyer showed at the poker table paid off, his daughter said.

My dad bought every grandchild their first car, she said. Nothing fancy, just good used cars. He made sure in his will that theres money set aside for my daughters first car as well.

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Hugh Freyer, Poker Player With Discretion of a Banker, Dies at 86 - The New York Times

Why Negreanu thinks Ivey is the best poker player in the world – Comcast SportsNet Chicago

NBC Sports Chicago recently caught up with six-time World Series of Poker bracelet winner Daniel Negreanu to talk about the type of player he's evolved into and a key moment from the beginning of his career.

Negreanu, who was promoting the subscription streaming service PokerGO, has cashed in 112 WSOP events, earning $14,908,224 in them.

"There's two ways of playing. One is called the Game Theory Optimal approach and the other is Exploitative," Negreanu said over the phone. "So the Game Theory Optimal approach is designed so that if you're playing against the perfect robot, there's one specific play or one way of playing a hand that is correct. And now, when you play exploitatively, you might know that but you go, 'I know this would be correct, but this guy here, he always folds. So I'm going to bluff him. More than I should.'

Related: Why Daniel Negreanu thinks betting 2020 Stanley Cup Playoffs is 'huge wildcard'

"So what I learned over the last couple of years is how to incorporate both Game Theory Optimal play and Exploitative because I was purely one-hundred percent Exploitative until the last few years that I learned it was important to have some balance of myself because when you do veer from Game Theory Optimal you do become exploitable yourself and some of the top players are doing that against me."

Negreanu, now forced to play online like many others, is trying to eliminate the tendencies he sometimes displayed earlier in his career.

Related: WSOP's Daniel Negreanu says no questionable algorithm in online poker sites

"I wouldn't describe them as risks, I would say that I've had tendencies that if somebody is paying attention... So for example, as simple as this, when I bet all my chips on the river, I'm not bluffing. If my top opponents know that, now they can start making really big folds and their exploiting a weakness in my lack of balance in the situation because what you want to have, on the river you want people to think like, 'Well, alright... he could be bluffing, he could have it.' When they know specific things about what you'll do in a situation, they can take advantage of you," Negreanu said.

Daniel won the first WSOP event he ever played in, the $2,000 Pot Limit Hold'em event in 1998 when he was 23. As he pulled all the chips in, Negreanu became the youngest player to ever win a WSOP bracelet at the time.

Related: Why Daniel Negreanu thinks Phil Ivey is the best poker player in the world

"I was just happy to be in the money, then I was at the final table and I was like, 'Wow, this is cool.' All of a sudden, I found myself heads up in a form called Pot Limit Hold'em, which I never really played before. ... In the final hand, we both had about even chips and I had ace-queen of hearts and he had the jack-10 of clubs and the flop came queen, jack, four with two clubs and one heart. So I had the top pair, he had the second pair, but he had a four card flush, a three card straight... He had a ton of outs.

"The turn card was a blank, the river was a little black card and I couldn't even see it because I was just so emotionally invested, but I did see some people cheering for me, raising their arms. I was like, 'Alright, that means it's not a club.' And it was the six of spades. I won on the very last hand. An absolute what's called a 'coin flip' situation. The odds of me winning the hand right after the flop were around fifty-fifty."

Related: How WSOP's Daniel Negreanu uses someone's appearance as a tell

PokerGO is showing classic moments from the World Series of Poker every night at 7 p.m. ET.

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Why Negreanu thinks Ivey is the best poker player in the world - Comcast SportsNet Chicago

Facebook develops AI algorithm that learns to play poker on the fly – VentureBeat

Facebook researchers have developed a general AI framework called Recursive Belief-based Learning (ReBeL) that they say achieves better-than-human performance in heads-up, no-limit Texas holdem poker while using less domain knowledge than any prior poker AI. They assert that ReBeL is a step toward developing universal techniques for multi-agent interactions in other words, general algorithms that can be deployed in large-scale, multi-agent settings. Potential applications run the gamut from auctions, negotiations, and cybersecurity to self-driving cars and trucks.

Combining reinforcement learning with search at AI model training and test time has led to a number of advances. Reinforcement learning is where agents learn to achieve goals by maximizing rewards, while search is the process of navigating from a start to a goal state. For example, DeepMinds AlphaZero employed reinforcement learning and search to achieve state-of-the-art performance in the board games chess, shogi, and Go. But the combinatorial approach suffers a performance penalty when applied to imperfect-information games like poker (or even rock-paper-scissors), because it makes a number of assumptions that dont hold in these scenarios. The value of any given action depends on the probability that its chosen, and more generally, on the entire play strategy.

The Facebook researchers propose that ReBeL offers a fix. ReBeL builds on work in which the notion of game state is expanded to include the agents belief about what state they might be in, based on common knowledge and the policies of other agents. ReBeL trains two AI models a value network and a policy network for the states through self-play reinforcement learning. It uses both models for search during self-play. The result is a simple, flexible algorithm the researchers claim is capable of defeating top human players at large-scale, two-player imperfect-information games.

At a high level, ReBeL operates on public belief states rather than world states (i.e., the state of a game). Public belief states (PBSs) generalize the notion of state value to imperfect-information games like poker; a PBS is a common-knowledge probability distribution over a finite sequence of possible actions and states, also called a history. (Probability distributions are specialized functions that give the probabilities of occurrence of different possible outcomes.) In perfect-information games, PBSs can be distilled down to histories, which in two-player zero-sum games effectively distill to world states. A PBS in poker is the array of decisions a player could make and their outcomes given a particular hand, a pot, and chips.

Above: Poker chips.

Image Credit: Flickr: Sean Oliver

ReBeL generates a subgame at the start of each game thats identical to the original game, except its rooted at an initial PBS. The algorithm wins it by running iterations of an equilibrium-finding algorithm and using the trained value network to approximate values on every iteration. Through reinforcement learning, the values are discovered and added as training examples for the value network, and the policies in the subgame are optionally added as examples for the policy network. The process then repeats, with the PBS becoming the new subgame root until accuracy reaches a certain threshold.

In experiments, the researchers benchmarked ReBeL on games of heads-up no-limit Texas holdem poker, Liars Dice, and turn endgame holdem, which is a variant of no-limit holdem in which both players check or call for the first two of four betting rounds. The team used up to 128 PCs with eight graphics cards each to generate simulated game data, and they randomized the bet and stack sizes (from 5,000 to 25,000 chips) during training. ReBeL was trained on the full game and had $20,000 to bet against its opponent in endgame holdem.

The researchers report that against Dong Kim, whos ranked as one of the best heads-up poker players in the world, ReBeL played faster than two seconds per hand across 7,500 hands and never needed more than five seconds for a decision. In aggregate, they said it scored 165 (with a standard deviation of 69) thousandths of a big blind (forced bet) per game against humans it played compared with Facebooks previous poker-playing system, Libratus, which maxed out at 147 thousandths.

For fear of enabling cheating, the Facebook team decided against releasing the ReBeL codebase for poker. Instead, they open-sourced their implementation for Liars Dice, which they say is also easier to understand and can be more easily adjusted. We believe it makes the game more suitable as a domain for research, they wrote in the a preprint paper. While AI algorithms already exist that can achieve superhuman performance in poker, these algorithms generally assume that participants have a certain number of chips or use certain bet sizes. Retraining the algorithms to account for arbitrary chip stacks or unanticipated bet sizes requires more computation than is feasible in real time. However, ReBeL can compute a policy for arbitrary stack sizes and arbitrary bet sizes in seconds.

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Facebook develops AI algorithm that learns to play poker on the fly - VentureBeat

Covid-19 testing delays create a public health nightmare as schools and workplaces try to reopen – CNBC

Adriana Cardenas, a medical technologist processes test samples for the coronavirus at the AdventHealth Tampa labs on June 25, 2020 in Tampa, Florida.

Octavio Jones | Getty Images

Across much of the U.S., concerned citizens are lining up to get tested for the coronavirus, only to wait a week or longer for their results to arrive.

With the country mired in its worst pandemic in a century, health experts are apoplectic about the length of the testing delays. In addition to the anxiety it causes patients, the lag time is disastrous for public health, because infected people aren't being quarantined in a timely fashion and it's impossible to retrace their steps to find others who have been exposed.

The inability for the U.S. to establish an efficient testing system, five months into the crisis, is one reason why numerous states continue to hit record infection rates and why the nation as a whole has far more cases than any other country.

"The wheels have fallen off the wagon," said Susan Butler-Wu, an associate professor of clinical pathology at the University of Southern California's Keck School of Medicine.

What's gone wrong?

A lot. At the highest level, demand for Covid-19 tests is outstripping supplies. The polymerase chain reaction, or PCR, tests are considered the most accurate on the market but, like with all tests, labs across the country can't access them fast enough.

Butler-Wu, who has a clinical microbiology lab in Los Angeles, said there's huge pressure to "test, test, test" for the virus without a coherent strategy to ensure that clinical and commercial labs have sufficient supplies.

A survey from June shared by the College of American Pathologists found that 64% of labs reported difficulty in acquiring reagents a mixture that's used in chemical analysisfor their platforms and test kits. Among respondents, 60% were struggling to get nasopharyngeal swabs to collect and transport patient samples, and more than half found it a challenge to get viral transport media to conduct the tests.

"At this point, I think testing delays are happening all over the U.S.," said Steven Pergam, an associate professor in the vaccine and infectious disease division at Fred Hutchinson Cancer Research Center. "But it depends on where patients seek care, how well funded the public health organizations are in that state and where the tests go."

Basic needs are also in short supply. Labs say they don't have enough plastic disposables, like tips and tubes. Staffing is a major problem, with lab techs already taking increased shifts and too few trained engineers available toservice the instruments when they break down.

Facilities can't forecast how many tests they'll be able to perform because they don't know when or if they'll be getting the supplies they need.

"I'd be happy to get three-quarters of what our suppliers tell us we'll receive," said Karen Kaul, chair of the Department of Pathology and Laboratory Medicine at NorthShore University Health System. "It might be different for the big commercial labs but right now, at the hospital level, we are often getting 10%."

Fred Turner, CEO of Curative, a company working on Covid-19 tests, saideven the large commercial labs like Quest Diagnostics are struggling to keep up because they aren't built for rapid scaling. That's particularly true in parts of the country where Covid-19 is spiking, like the South.

"They are built for driving down margins with roughly stable volumes," Turner said.

At the heart of the failure to date is the lack of a national strategy to address the need for rapid and widespread testing. Ideally, we'd be able to open locations as needed in areas with outbreaks and to source products that could be manufactured and shipped to those locations. The government would also be funding new technology and providing grants for institutions to expand their resources.

"It would be great to put more money into diagnostics, and that's really important," said Butler-Wu. "But real money needs to go to a plan, meaning a nationalized response."

The problem is evolving. The more infection rates extend into smaller, less urban communities, the less prepared we are, because the top medical institutions tend to be centered around big cities and universities.

"The next concern for us is that rural communities won't have access to the same testing strategies and are relying more on industry and places like LabCorp,"said Pergam. "Many aren't getting quick results."

Some infectious disease experts and technologists are calling for new approaches. To ramp up to millions of testsper day, as more people look to get a clean bill of health and return to work or school, companies are developing rapid, at-home tests that can return a result in a matter of minutes.

Such tests could, in theory, be self-administered.

Whether they'll be sufficiently accurate remains a big question, but some experts say that for people who just need frequent tests so they can comfortably go to work, this method could still be useful.

"We could have a slightly less accurate test that emphasizes frequency and turnaround time," said Jeff Huber, a former Google executive who's now helping fund companies that are developing such tests.

Others say there may be a path forward for these new tests, but it could be challenging to convince the industry to adopt them.

Health care workers are seen at a pop-up COVID-19 testing clinic in Rushcutters Bay on July 29, 2020 in Sydney, Australia.

Jenny Evans | Getty Images News | Getty Images

"One of the reasons people may be slow to move in that direction is because we want every test to perform as well as the best test," said Rich Davis, a clinical microbiology lab director at Providence Sacred Heart Medical Center."But that's not always possible, and adoption of a new approach requires the adoption of a new way of thinking about what the test does."

Adding to the pressures surrounding the rapidly spreading coronavius is the rapidly moving calendar. Flu season is just around the corner, and many states are preparing to reopen schools in a matter of weeks.

That means more stress on a testing infrastructure that's already suffering from extreme backlogs.

"It's very worrisome," said Kaul. "What happens when the companies making influenza reagents switch to Covid? We'd have to choose which test we perform."

Butler-Wu agrees that this could become a major problem unless things change.

"There will be a knock-on effect when it comes to testing for other conditions," she said. "Many of us are going to be made to prioritize."

WATCH: LabCorp CEO on speeding up Covid-19 test results

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Covid-19 testing delays create a public health nightmare as schools and workplaces try to reopen - CNBC

Wrong! Trump and Fauci clash over surge in COVID-19 cases, reopening of economy and hydroxychloroquine – MarketWatch

Anthony Fauci and President Trump are still at odds.

Fauci, director of the National Institute of Allergy and Infectious Diseases for three decade who has worked on the front lines of the AIDS pandemic in the 1980s and 1990s, the Ebola outbreak of 2014 to 2016 and the anthrax attacks two decades ago, testified before Congress last week that the U.S. should have taken speedier and more comprehensive action to close businesses when coronavirus first appeared in the U.S. earlier this year.

Fauci said the U.S. effectively only shut down half the economy. If you look at what happened in Europe when they shut down, or locked down, or went to shelter-in-place, however you want to describe it, they really did it to the tune of about 95% plus, he told the hearing. When you actually look at what we did, even though we shut down, even though it created a great deal of difficulty, we really functionally shut down only about 50% in the sense of the totality of the country.

President Trump hit back at Fauci on Twitter TWTR, -0.87% on Saturday evening, replying to a post by CBS News VIAC, +1.00% of Faucis testimony. Wrong! We have more cases because we have tested far more than any other country, 60,000,000. If we tested less, there would be less cases. How did Italy, France & Spain do? Now Europe sadly has flare ups. Most of our governors worked hard & smart. We will come back STRONG!

Nearly 53 million people have been tested for coronavirus in the U.S. to date, according to the Centers for Disease Control and Prevention, with more than 5 million or 10% of those testing positive for the virus. Wait times of more than 10 days have become the norm for many Americans. There are, however, stories of people who have had to wait 26 days to get their results. Waiting 10 days for a test defeats the purpose of getting tested, some health professionals say.

Approximately half of the tests being performed daily are conducted by commercial labs such as Quest Diagnostics DGX, +0.24% and LabCorp. Only one state has an average turnaround time of greater than five days, said Admiral Brett Giroir, a member of the White House coronavirus task force. Five states are between four and five days. 26 states are still three days or less, and the rest are between three and four days. Turnaround times of 10 to 12 days represent outliers, he added.

The Trump administration, meanwhile, is trying to block $25 billion for states to conduct testing and contact tracing in the next coronavirus relief bill, people involved in the talks told the Washington Post this month. Democratic lawmakers, in negotiations over a new stimulus bill, have demanded $25 billion for the testing and contact-tracing, over three times what the GOP have suggested. Contact tracing identifies people who someone with COVID-19 has come into contact with.

At the U.S. House Select Subcommittee on the Coronavirus Crisis, Fauci reiterated that there was no scientific evidence to show that hydroxychloroquine was helpful for coronavirus patients. You look at the scientific data and the evidence, and the scientific data, on trials that are valid that were randomized and controlled in the proper way; all of those trials show consistently that hydroxychloroquine is not effective in the treatment of coronavirus disease or COVID-19.

When asked by Republican Rep. Blaine Leutkemeyer from Missouri about a peer-reviewed study suggesting otherwise, Fauci said, The Henry Ford Hospital study that was published was a non-controlled retrospective cohort study that was confounded by a number of issues, including the fact that many people who were receiving hydroxychloroquine were also using corticosteroids, which we know from another study gives a clear benefit in reducing deaths with advanced disease.

So that study is a flawed study, and I think anyone who examines it carefully [would see] that it is not a randomized placebo-controlled trial. You can peer review something thats a bad study, Fauci said, adding, I would be the first one to admit it and to promote it, but I have not seen yet a randomized placebo controlled trial thats done that. I dont have any horse in the game one way or the other. I just look at the data.

Social-media sites attempted to quash a video pushing misleading information about hydroxychloroquine as a COVID-19 treatment which led to Twitter partially suspending Donald Trump Jr.s account. The video featured doctors calling hydroxychloroquine a drug used to treat malaria, lupus and rheumatoid arthritis for decades a cure for COVID, despite a growing body of scientific evidence that has not shown this to be true.

As of Sunday, COVID-19, the disease caused by the virus SARS-CoV-2, had infected at least 17.9 million people globally and 4.6 million in the U.S. It had killed over 686,877 people worldwide and at least 154,793 in the U.S., according to Johns Hopkins University. Cases in California surpassed 500,000 as the state reported 7,118 new cases Saturday, with 134 new deaths, bringing the death toll in that state to 9,365. New York has the most fatalities (32,710) followed by New Jersey (15,836).

The Dow Jones Industrial Index DJIA, +0.43% closed higher Friday, as investors tracked round two of the potential fiscal stimulus. The S&P 500 SPX, +0.76% and Nasdaq Composite COMP, +1.48% alsoended the week after some of the industrys largest and most powerful players Apple AAPL, +10.46% Facebook FB, +8.17%, Amazon. AMZN, +3.69% and Google parent Alphabet Inc. GOOGL, -3.27% GOOG, -3.16% reported their results.

Related:Dr. Fauci tells MarketWatch: I would not get on a plane or eat inside a restaurant

Health professionals, economists and lawmakers are concerned about the rise in coronavirus over the last month with the rise in daily cases exceeding 1,000 for the sixth consecutive day on Saturday. The U.S. cannot afford to have a resurgence of the virus either now or in the fall, health professionals say. For one, its harder to get people to practice social distancing and stay home again, especially after theyve already abided by stay-at-home orders for more than 11 weeks.

Secondly, the effect on the economy could push the U.S. into a prolonged recession, even greater than the one already predicted by some economists, despite some observers seeing public health and economic health as an either/or scenario. Thirdly, the flu season will already be upon us in the winter and those symptoms are easily confused with those of COVID-19. Fourthly, too few people will be immune to COVID-19 after this first wave ends to support herd immunity.

Another thing to consider: Given the age profile of fatalities in the U.S. and other countries, elderly people would die in far greater numbers if the economy were restarted earlier. Paul Zak, a neuroscientist and author of The Moral Molecule: The Source of Love and Prosperity, said a trade-off between the economy and allowing (older) people to die of COVID-19 reflects that society values people on their economic output, which ignores a multitude of other factors.

Its appalling to attach a dollar number to a human life for non-economists, Colin Camerer, a professor of behavioral finance and economics at the California Institute of Technology in Pasadena, told MarketWatch. You can never make things perfectly safe with zero risk. We do have limited time, health-care staff, ventilators and money. What is the curve of transmission? How many people are going to die, if you open up the economy? No one is really too sure.

Trump has said he is also concerned about the impact of the pandemic and job losses on peoples mental health; some studies suggest it could lead to tragic outcomes. The growing epidemic of deaths of despair in the U.S. is also increasing due to the pandemic and another 75,000 more people will likely die from drug or alcohol misuse and suicide, according to research from the Well Being Trust, and Robert Graham Center at the American Academy of Family Physicians.

The response to the virus has been split down political lines. The American public has responded differently to the pandemic along political lines: 62% of Republicans and Republican leaners say the seriousness of COVID-19 is generally exaggerated, according to one survey, while just 31% of Democrats and Democrat leaners and 35% of independents say the same. Democrats and independents are more likely than Republicans that coronavirus is a threat.

How COVID-19 is transmitted

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Wrong! Trump and Fauci clash over surge in COVID-19 cases, reopening of economy and hydroxychloroquine - MarketWatch

Coronavirus: The hidden heroes of Indias Covid-19 wards – BBC News

Image caption Hospital assistants - or ward boys, as they are known - play a crucial role in India

One morning in June, Deep Chand spotted a distraught family member of a Covid-19 patient standing outside the coronavirus ward in a hospital in India's capital, Delhi.

The man was desperately trying to speak to a doctor or nurse to find out about the condition of his relative who was a patient in the ward.

But it was a terrible day for doctors - some patients had died, a few others were critical, and new patients were being wheeled in throughout.

So Deep Chand, who worked as a ward boy - or assistant - walked up to the man and asked if he could help.

That man was me, and I was trying to find out how my brother-in-law was doing. It had been three days since he was put on a ventilator.

Doctors usually called every day to update us, but on that day no-one seemed to have time to do that.

When Deep Chand came up to me, I mistook him for a doctor because he was wearing personal protective equipment (PPE) and I threw a volley of questions at him.

"I am a ward boy and I can't help you with these questions," he said.

I must have sounded desperate and even rude, but he responded softly, without irritation.

He told me that my brother-in-law's blood oxygen level was fine, and there had been no turn for the worse in the last 10 hours.

That's how I met Deep Chand, 28. Ward boys are nearly at the bottom of the hospital's hierarchy. They have no professional medical training, and their job is to assist doctors and nurses as well as help patients.

This includes everything from taking samples for testing, wheeling patients across the hospital for X-rays, serving them food, and sometimes just talking to them. And amid the painful chaos of the pandemic, these ward boys have become a source of support not just for patients but also for their families.

I will never forget my reassuring interaction with Deep Chand because it's just what I needed to hear while I waited for an hour outside the ward, anxious and scared. I could hear the sounds of the machines, patients yelling in pain and doctors and nurses shouting instructions at each other.

I also distinctly remember a patient pleading: "I can't breathe, please save me!"

Deep Chand's words cut through my panic and I ran to the car park to update my family - we nervously smiled at each other while standing at a safe distance.

This was the worst part - we couldn't hug or even hold hands when we desperately needed comfort. We had to maintain distance to protect each other. Not being able to hold each other - while my wife's brother was breathing through a machine - had become routine.

Even on a day the doctor told us "the next 12 hours are critical", we all broke down in our respective corners of the car park.

In the days that followed, we often relied on Deep Chand and his colleagues whenever doctors were too busy to give us updates.

We spent tense hours at home or in the hospital waiting for news from the ward.

It was difficult because the first two weeks of June saw a massive surge in Delhi's Covid-19 case numbers. Most hospitals were overrun, including the one where my brother-in-law was admitted.

In that chaos, ward boys like Deep Chand became messengers for dozens of families like ours.

I would often see them consoling families, supporting them and taking messages to those patients who were too ill even to talk on the phone.

One day when my brother-in-law's condition deteriorated, I was standing outside the ward and I broke down.

The doctor's update was factual. "We can't say anything at the moment, he is not improving."

But a ward boy walked up to me and said: "Don't worry, I have seen even severely ill patients recover."

His hopeful words gave me some relief.

When doctors keep repeating "anything can happen", the mind takes you to dark places. It made me doubt everything.

Did we pick the right hospital? Should we have listened to him instead of convincing him to go on the ventilator? It had been a tough call - he had been against it, and the doctors kept saying there wasn't much time left to waste.

My family kept crying but praying for the "miracle" Deep Chand had told us was possible.

It was one of the most difficult times in my life, and Deep Chand's kind, calming words meant a lot to me - especially when I wasn't able to speak to the doctors.

Speaking to me on the phone now, more than a month later, he says he felt the pain of the families but there was little that the doctors and nurses could do to improve communication.

"They were so busy, they somehow managed to speak to the families of serious patients once a day. It's nobody's fault - none of us were prepared for this kind of rush," he says.

Instead, it was Deep Chand and other ward boys who would share what information they could about the patient's progress - they routinely informed me about my brother-in-law's blood oxygen level.

"I can see the oxygen saturation level on the monitor and I don't mind sharing that information with families," Deep Chand says.

I also saw Deep Chand take food and letters for patients from their families.

He says he has been working as a ward boy for five years, but Covid-19 has completely changed the way he works.

He adds that being in protective equipment for 10-12 hours is painful, but it's nothing "compared to what patients and their families go through".

His colleague, Amit Kumar, nods in agreement, while speaking to me outside the Covid-19 ward one day. He says that even a little information goes a long way in reassuring families.

"Sometimes the families feel happy with little things - like when we tell them that the patient ate properly today or he smiled in the morning."

Every day, ward boys risk their lives in hospitals across the country. Hundreds of them have been infected with the virus. Some have even died. But their contribution in the fight against Covid-19 is seldom mentioned.

The ward boys I spoke to say this doesn't bother them. Deep Chand says he is not looking for special recognition.

When he was told that he would have to work in the "corona ward" at the start of the outbreak in March, he admits was concerned. "I was terrified for my safety and that of my family."

But then, he adds, he realised that he would not think twice before going into the ward if one of his family members was sick.

"Every patient is somebody's family."

That thought drove him to start working in the ward in April, and since then he has never considered quitting.

And doctors appreciate this. "Ward boys are an important part of any ICU unit," says Dr Sushila Kataria, the director of intensive care at Medanta Hospital.

"They watch our backs, they deal with discarded PPE kits and contagious samples. No doctor can work without their help," she says.

"They are also heroes in this fight like doctors and nurses."

But they are some of the lowest-paid employees in a hospital. The situation is worse in smaller towns where they are hired by contractors who lease their services to hospitals.

Sohan Lal works in a government-run hospital in the northern state of Bihar and earns 5,000 rupees ($66: 52) a month.

He says it's a paltry amount given the risk of working in a Covid-19 ward. "But I don't have any other job, so I will keep doing this. I also realise the importance of my job."

He adds that so many times he has given medicines to patients after consulting the doctor on the phone.

"Doctors seldom come for rounds more than once a day. So, patients rely on ward boys to convey their messages to the doctors."

The other tough part of their job is seeing death so closely. Deep Chand says he feels distraught when a patient he has been caring for dies.

"Sometimes patients die after spending more than two weeks with us. They almost become like our family," he says.

But, he adds, he won't stop "until we defeat corona or it defeats me".

I wanted to specially thank him the day my brother-in-law was discharged after nearly a month in the hospital. But he disconnected my call, saying "he was on duty".

A text followed: "You don't need to thank us", he wrote. "Pray for us and all medical teams working in Covid-19 wards across the world".

And he had a message too: "Please wear masks and follow social distancing."

I can't agree with him more, having seen the worst of what this virus can do.

Continued here:

Coronavirus: The hidden heroes of Indias Covid-19 wards - BBC News

Marlins forced to make roster moves during COVID-19 outbreak; here are the pitchers Miami has added – CBS Sports

The Miami Marlins have not played a game since last Sunday due to a team-wide COVID-19 outbreak that resulted in 18 players testing positive throughout the week. The Marlins have not had any positive tests over the last two days, however, and Major League Baseball set their return to the field for Tuesday vs. the Orioles. Marlins players who contracted COVID-19 will need two negative tests at least 24 hours apart before returning to action, so Miami's lineup and roster will look different on Tuesday in Baltimore than they did July 26 in Philadelphia.

While the exact parameters of Miami's outbreak are unknown, it seems that the Marlins' front office is in the process of rebuilding at least a segment of its roster -- in part because it has no choice. They made a trade early Saturday, acquiring left-handed reliever Richard Bleier from the Baltimore Orioles in exchange for a player to be named later.

Bleier is the fourth pitcher the Marlins have acquired through trade or waivers this week, joining Justin Shafer, Josh D. Smith, and Mike Morin. (Keep in mind, these pitchers have had little say in joining the team that, at least so far, has been hit the hardest by the pandemic.)

So what should the Marlins and their fans expect from the new additions? Here's a quick scouting report on some of the new Miami arms.

Richard Bleier, 33, has had the most success of anyone in the quartet. From 2016-18, he made 111 appearances and notched a 1.97 ERA. He's been limited to 55 appearances since the onset of the 2019 season, and hasn't been nearly as successful. Bleier doesn't throw hard and relies on generating soft groundball contact. He's coerced at least 55 percent grounders in each of his big-league seasons, according to Statcast.

Mike Morin, 29, has a career 87 ERA+ but continues to find work thanks to solid underlying numbers, including a 3.25 strikeout-to-walk ratio. Last season, that ratio had more to do with a lack of walks (1.8 per nine) instead of a ton of strikeouts (4.6 per nine). Morin pairs a low-90s fastball with a slow changeup that often arrives in the low-70s. Opponents hit .138 versus the parachute piece with an 84.4 mph exit velocity-against in 2019. Managing contact by keeping batters off-balance is the key to him remaining employable.

Josh D. Smith, 30, is in his second stint with the Marlins, having finished last season with the club following a waiver claim from Cleveland. (The Cincinnati Reds then claimed him off waivers in October.) Smith's fastball only averages 90 mph, but might be sneaky effective thanks to a spin rate that placed in the 99th percentile in 2019. He has a crossfire delivery and a low three-quarters/sidearm release point, suggesting he should be tough against left-handed hitters.

Justin Shafer, 28 come mid-September, has a 3.75 ERA (121 ERA+) in 40 career appearances. Pretty good, so why was he available on waivers? Because of his wild tendencies. Shafer has walked 32 batters in 48 innings, a rate that equals six per nine innings. To his credit, he's shown he can evade bats with a high-spin mid-90s fastball and a mid-80s slider.

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Marlins forced to make roster moves during COVID-19 outbreak; here are the pitchers Miami has added - CBS Sports

An Indiana school reopened for students. There was a positive COVID-19 test on day one. – USA TODAY

The Indiana Department of Education has released these guidelines to help school officials and parents decide how schools can reopen safely during the coronavirus pandemic. Wochit

INDIANAPOLIS A junior high school in Greenfield, Indiana, received news on the first day of class that a studenttested positive for the coronavirus, according to an email sent to families Thursday evening.

The student attended part of the first day of classes at Greenfield Central Junior High School. It was the first time students had been back in the school buildings since the coronavirus closed schools statewide in March.

The school district told families that its "Positive COVID-19 Test Protocol" was enacted as soon the school was alerted by the Hancock County Health Department about the positive test. The student was immediately isolated and all close contacts were determined.

A water tower in Greenfield, Indiana, Saturday, May 9, 2020.(Photo: Robert Scheer/IndyStar)

Hancock County Health Department Officer Sandra Aspy said in an emailed statement the department was notified of the student's positive test on Thursday. The department then "immediately" contacted the school.

According to the Indiana State Department of Health's COVID-19 dashboard, Hancock County has reported 597 total cases of the novel coronavirusand 37 deaths as of Friday.

Share your back-to-school coronavirus story: How are you preparing for school reopening?

Families of students considered a close contact someone who spent more than 15 minutes within six feet of an infected person were contacted Thursday night, the district said.

SuperintendentHarold Olin declined to say how many students were identified as close contacts. He said district nurses and the administration helped identify those people.

"Because we are able to narrow this list, there is no reason to disrupt the educational process for the larger group that is served within the school," Olin said in an email.

Olin did not know whether the student had symptoms. It is possible for the coronavirus to be spread even by those who are not showing symptoms.

Aspy, the health officer, said she would not release any "personally identifiable information" about the infected student or the student's close contacts.The health department declined to tell IndyStar, part of the USA TODAY Network, whether the student had symptoms, when the test was administered or how many close contacts were identified.

The district said that all areas of all schools are disinfected every night after school and special attention was given to classrooms in which the infected student was present.

A person who tests positive must isolate at home for 10 days, according to the district's reopening plan. For those with symptoms, they must be fever-free without medication for 72 hours before returning to school, in addition to quarantining for 10 days.

Olin said the district does not intend "to deviate from the plan at this time, though we are certainly willing to do that if our health department identifies more appropriate protocols and procedures for us to institute."

Back to school: National union supports teacher strikes if schools' reopening plans aren't safe enough

It's unclear when the student was tested, but getting results typically takes days, indicating the student was tested prior to the first day of school.

The Indiana Department of Education's guidance to school districts saysif students or staff have "someone in their home being tested for COVID-19," the district can exclude that person from school and recommend they quarantine for 14 days.

Aspy said anyone awaiting results should remain in isolation until results are received.

But the Greenfield district's plan for reopening schools does not offer specificguidance on what students or staff should do if they have a pending test.

Families of students at Greenfield Central Junior High School were notified on the evening of July 30 that a student had tested positive for the novel coronavirus after attending the first day of classes. The student went to school despite having been tested and not yet receiving the results.(Photo: Holly Hays/IndyStar)

What happens now:The plan after a case is reported

The plan says students and staff should stay home if sick and notify the school if they exhibit symptoms related to the novel coronavirus

The plan also says that anyone who hasclosecontact with a confirmed positive case must quarantine for 14 days before returning to school, regardless of whether they have symptoms.

Indiana's public schools are among the first in the country to start their academic years after the pandemic interrupted education nationwide in the spring.Debate continues about whether it is appropriate or safe to bring students back into schools for in-person instruction as the pandemic continues.

At the end of the school day Friday, the families of the middle school students waited in their cars to pick students up.

Some expressed frustration with the family of the student who tested positive for COVID-19, saying it was irresponsible for the student to go to school without waiting for results of the test.

I think its kind of selfish of the parents of the student," Samantha Kiefer, whose daughter is in eighth grade at the school, said, "sending their kids to school or kid to school knowing that they may or may not have it."

Sherry Root, the grandmother of an eighth and 11th grader, expects to see the overall number of cornavirus cases increase now that classes are back in session.

Maybe we came back a little early, Root said, "but I think the school is going to handle it in the best way they know how."

Laura Taylor, who was picking up her7th grader,said the school is doing the best it can to keep studentssafe. However,virtual learning seems like an inevitable outcome, especially since it took just one day for a confirmed case at the middle school and other districts are already online.

What needs to happen before we shut down? she asked.

Some area schools, including Indianapolis Public Schools and several of Marion County's township districts, have decided to restart the year virtually.

Contributing: Holly Hays and Pulliam Fellow Lydia Gerike, IndyStar

Follow IndyStar reporter Elizabeth DePompei on Twitter: @edepompei.

Follow IndyStar reporter Arika Herronon Twitter: @ArikaHerron.

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An Indiana school reopened for students. There was a positive COVID-19 test on day one. - USA TODAY