Freedom in Ukraine: Moving in the right direction? – The Ukrainian Weekly

Not all readers may be aware of the comprehensive and detailed U.S. government and NGO reports issued annually that assess the status of human rights and democracy, or religious freedoms, in countries around the world, including Ukraine. Several have been issued in the last few months. They include the State Departments Annual Human Rights Country Reports and its report on International Religious Freedom, as well as those from respected NGOs such as Freedom House. There is also a flow of information from other U.S. and international NGOs, the United Nations and other international bodies, and, of course, from Ukrainian NGOs, notably the Kharkiv Human Rights Protection Group.

These reports accurately address and assess the absolutely appalling state of human rights and elementary freedoms, democracy and the rule of law in the Russian-occupied territories a subject that this columnist has often written or spoken about in recent years. In these territories, human rights abuses, the severe repression of those who dare peacefully oppose the puppet regimes, suppression of civil and political liberties, and the persecution of religious groups with the notable exception of the Russian Orthodox constitute the norm.

However, this week, I will focus on human rights and freedoms for the roughly 85 percent of Ukrainians living under Kyivs authority. In doing so, I will mention a disconcerting trend that is causing growing concern in Washington and among Ukraines international partners.

Ukrainians enjoy basic human rights and freedoms and a vibrant civil society, and the government largely respects civil and political rights of all kinds including rights of national minorities and religious freedoms. Elections are democratic. But it is, as Human Rights Watch calls it, a mixed picture, and democratic Ukraine is not without human rights and democracy deficits.

These include torture and other abuse of detainees by law enforcement personnel, harsh prison conditions, and arbitrary arrest and detention albeit nowhere on the scale of what we see in the occupied territories. Ukraine also faces some restrictions on freedom of expression and the media, and serious weaknesses in the rule of law. Ukraine is still plagued by widespread government corruption although considerably less than the astronomical levels of the Viktor Yanukovych era.

In 2019, Freedom Houses authoritative Freedom in the World Index again ranked Ukraine as partly free the three designations being free, partly free, and not free. That score decreased slightly over 2018 because of increased attacks on anti-corruption activists and journalists, and on vulnerable communities such as the Roma.

With respect to democracy, Freedom House also recently issued its Nations in Transit report, where Ukraines democracy score in 2019 improved marginally over that of 2018. Some progress was made, for instance, with whistleblower protections or a law lifting parliamentary immunity, and the two free and fair national elections.

But the way things have been looking lately, I am not sure well see improvement this year, and I even fear backsliding.

In recent months, we have seen a growing pattern of questionable, seemingly politically motivated investigations or prosecutions of political opponents most notably former President Petro Poroshenko. Others, such as former Prosecutor General Ruslan Riaboshapka, who was dismissed in the unfortunate March government shake-up, and other reformers have faced investigations that appear to be politically motivated. There are ongoing attempts to undermine the head of Ukraines Anti-Corruption Bureau (NABU) Artem Sytnyk. Civil society activists such as Euro-Maidan activist Tatyana Chornovol and Odesa activist Serhiy Sternenko seem to be targeted. We also see what appears to be a shaky case against the alleged killers of journalist Pavel Sheremet.

The plethora of politically motivated, often frivolous, at times patently ridiculous charges being leveled against Mr. Poroshenko and others looks like political score-settling and is starting to remind many people of the Yanukovych era of selective justice. I would think and hope that Ukraines leadership will be smart enough not to invite these kinds of comparisons. If there really is sufficient credible evidence in any of these cases, then Ukrainian authorities need to go about prosecuting them in a manner consistent with the rule of law, with a presumption of innocence and a fair process. Selective justice most assuredly does not serve Ukraines interests it divides society and harms its democracy and national security, which of course plays into Moscows hands. And it will not, to put it mildly, engender confidence from Ukraines many staunch supporters in Congress and elsewhere in the U.S. government, as well as Ukraines other international partners, or the international business community. It is also raising serious concerns in the diaspora, with statements from the Ukrainian World Congress, Ukrainian Congress Committee of America, Ukrainian Canadian Congress and Australian Federation of Ukrainian Organizations and others issued in recent weeks. [Editors note: See these statements on page 8.]

To add insult to injury, at the same time that we have these questionable cases, the truly bad actors, such as killers of Euro-Maidan activists, other human rights abusers, corrupt oligarchs and officials from the Yanukovych era go free or are protected. The recent State Department Annual Human Rights Country Report on Ukraine sums it up well: The government generally failed to take adequate steps to prosecute or punish most officials who committed abuses, resulting in a climate of impunity.

Clearly, there is still much work to do in cleaning up law enforcement entities, notably the Ministry of Internal Affairs under Minister Arsen Avakov, who has been criticized by many as blocking police reforms, and the Security Service of Ukraine (SBU), which is in need of serious changes, including separating its state security functions from its law enforcement powers thereby helping to eliminate its corruption. And the Prosecutor Generals Office, which had shown some promise in reducing corruption and other ills during Mr. Riaboshapkas brief tenure, has instead become involved in questionable, selective justice.

With respect to the judiciary, some progress has been made since the launch in the fall of 2019 of the Anti-Corruption Court. However, judicial reforms appear to have stalled, especially with respect to the process of the selection of judges. But the bottom line is that all too many judges are still not trusted.

Despite these concerns, perhaps one can take some comfort in the fact that Ukraine, while not really moving forward, at least has not significantly slipped backward. Or take solace in the fact that substantial progress has been made since the Maidan. Or that Ukraine has not regressed in recent years as have some of Ukraines European Union neighbors, notably Hungary and to a lesser extent Poland, who have been moving in the wrong direction.

Or one can be consoled that Ukraines human rights and democracy record is dramatically superior to that of Ukraines neighbors Russia and Belarus, which are decidedly not free countries. Indeed, for all of Ukraines shortcomings, Vladimir Putins war of aggression and persistent attempts to undermine Ukraine have not succeeded in knocking Ukraine from its path to democracy and moving it towards authoritarianism.

But Ukraine can do better, and has in the past. It was free for few years under Viktor Yushchenkos presidency. But this rating will not happen unless Ukraines leadership reforms its law enforcement and judicial system, and stops engaging in its wrong, foolish and self-destructive behavior by trying to settle political scores and unjustly pursuing political opponents.

Orest Deychakiwsky may be reached at odeychak@gmail.com.

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Freedom in Ukraine: Moving in the right direction? - The Ukrainian Weekly

Healing, Justice, and Freedom, as Defined by #BlackLivesMatter – Greatist

There is an Afrocentric concept called nommo. As Africa is not a monolith, it has more than one meaning, but the many definitions boil down to the power of the spoken word. For me, it always meant to be careful of what you say. You never know what you may speak into existence.

As a writer, and especially as a poet, Ive always found it important to measure my words carefully. Words are powerful. They shape the world around us. They shape our perception. And as a Black woman, Ive often felt my words crushed and overshadowed but Black Lives Matter, created by three Black women, has given a voice to my people.

Since 2013 they, along with the Movement for Black Lives, have spearheaded a new wave of anti-racist activism. Seven years later, we see these movements grow into a mass challenging of the American status quo: white supremacy, racism, and xenophobia. Hashtags have become chants in the streets. Black Lives Matter. I cant breathe. Say Her Name. Now, these cries are coming to fruition.

Im seeing white folk attempt to actively unlearn racism, taking the responsibility upon themselves as opposed to expecting Black folk to teach them. Im seeing white allies march alongside Black and Brown bodies, using their privilege to further the movement. Its now time to look forward. Im seeing folks acclimating to the ideas that are closer to the goals of the movement, like defunding the police or ending qualified immunity.

As we attempt to reach these goals, though, they also get distorted by those who would like a softer landing. The conversation around defunding the police is a prime example, in which op-eds have argued that defunding means reform or adding social workers to the police force.

So Ive been thinking: What will it take for folks to listen to each word we say? How do we speak into existence a Black community that will thrive?

We need to be on the same page for healing, justice, and freedom.

Black people are predisposed to a litany of health issues, both physical and mental. To heal, we have to begin to piece together our communities and ourselves.

We can look at spaces like Ethels Club in Brooklyn for community healing. Prior to the pandemic, Ethels Club served as a community and coworking space for people of color. Now, its digital membership offers wellness and workout sessions, connection to a community of creatives, and a ton of PoC-focused events.

Healing also looks like mutual aid. Mutual aid doesnt simply consist of monetary donations it is doing grocery runs for elderly or immunocompromised folk during COVID-19. It is stocking community fridges, offering/exchanging services, or picking up your neighbors kids from school.

Healing is found in caretaking. Its found in radical Black joy or reconnecting with our roots. Healing is also having difficult conversations, ones that can break the cycles we exert in order to oppress each other. Doing this allows us to unite in unapologetic Blackness.

We cannot forget that this country was born with three major birth defects, says Dr. Ama Mazama, director of graduate programs in the African American Studies department at Temple University, the annihilation of the Native people, the enslavement of African people, and the grabbing of two-thirds of Mexican land.

To wrangle justice from the hands of a society born with these birth defects has proven difficult. The protests in Minneapolis were referred to by multiple media outlets as riots. Public officials have called protesters animals as they were shot with tear gas. Yet white people often get let off the hook when they destroy cities for the sake of sports.

Vanessa Belleau, the founder of Highfifteen, specializes in unconscious bias training within the workplace. She defines justice as the idea that finally our point of view and experience gets acknowledged by the oppressor. Or that there is a reparation of some sort, a sentence even for the oppressor.

This concept, surprisingly, already exists and has been played out in the Western world before. Germany has addressed its Nazi past through the steps Belleau mentions. Its called vergangenheitsbewltigung. This term, which has no direct translation, describes the series of steps Germany took to atone for its sins. After World War II, the country sought to reunite families, paid reparations, memorialized the dead, and punished those who committed crimes.

The United States could step up in a similar way to aim for justice in the long haul. It could first acknowledge the deep-seated issues this country has. Another start would be the sentencing of those who murder Black folk in cold blood and a removal of qualified immunity. There would be no grand jury. There would be no pension waiting for police who murder.

Nobodys free until everybodys free. Fannie Lou Hamer

Freedom is sacred to Black folk, as weve so frequently seen it taken away from us from the enslavement of Africans to the Jim Crow era caste system to todays prison industrial system. In the past 50 years, the number of people in U.S. prisons has increased 700 percent. One-fourth of Black men and one-sixth of Latino men can expect to know what the inside of a prison cell looks like. These two groups comprise about one-third of the U.S. population, yet they account for 59 percent of the state prison population.

The Thirteenth Amendment didnt end slavery wholesale, as it allowed for the enslavement of those who have committed crimes.

Freedom looks like equality. Freedom looks like harmony. Freedom is the combination of healing and justice. For all of us. Not just Black men. Not just Black people. Freedom is equal protection for all races, the LGBTQ+ community, the disabled, the unhoused, and on and on

When we can return to our traditional ways of being and invoke community once more, we will be free. As an Afrocentrist, Mazama easily draws her conclusions to the past. She references the Kemetic principles of Maat, truth, balance, order, harmony, law, morality, and justice. Maat itself refers to the balance of the universe, and these principles guide us toward peace.

The challenge that we face is the restoration on Maat, says Mazama, in a world permeated with injustice and abuse.

The movement has been clear in its demands of no justice, no peace. As we teeter between the two, the future, surprisingly, looks more bright.

Gabrielle Smith is a Brooklyn-based poet and writer. She writes about love/sex, mental illness, and intersectionality. You can keep up with her on Twitter and Instagram.

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Healing, Justice, and Freedom, as Defined by #BlackLivesMatter - Greatist

Survival of Americas experiment depends on how we use freedom – Crux: Covering all things Catholic

Throughout the United States, Americans are celebrating Independence Day. Even in a pluralistic society, with different worldviews and values, nothing unites the American people more than an appeal to freedom.

And yet, sometimes the obvious things can be overlooked. For example, it might be beneficial for us to ask: What is freedom? Why is it so essential to a civil society and to the great American experiment?

The moral law, which is given by God and which resonates in the hearts of all people of goodwill, teaches humanity, true freedom. Freedom is often poorly defined as an ability to do whatever we want, but freedom is actually the ability to do what is right. Due to our fallenness, whenever we are left to own devices, we choose darker things and deprive ourselves of authentic freedom.

Freedom is an openness to God, which allows him to work within our interior lives. It is a maturity of the soul that empowers us to act above our passions and desires. Freedom shows us the proper order of things and summons us to do what is right. As human persons, we have to grow into our freedom and safeguard it, so that it does not become enslaved itself.

St. Paul summarizes these truths when he writes: For freedom Christ has set us free; stand fast therefore, and do not submit again to a yoke of slavery.

And again, the Apostle writes: Now the Lord is the Spirit, and where the Spirit of the Lord is, there is freedom.

In this way, freedom itself highlights the proper relationship between the moral law and itself. Oftentimes, the moral law and freedom are falsely portrayed as being in contradiction, as if the two are in tension with one versus the other. The reality, however, is that there is no versus between the moral law and freedom, but rather a rapport of via, meaning by way of, which demonstrates that the law is in service to freedom and freedom benefits from the discipline of the law.

The moral law helps us to be free. The person, therefore, who repeatedly breaks the moral law lives a life according to his passions and desires. The persons freedom is enslaved. He is not free. For the person to mature fully, he needs both the law and freedom, and together they pave the way for a virtuous life.

Virtue is best understood as a good habit which governs human action, orders the passions within our hearts, and guides us into conduct according to faith and reason. Freedom is the power to make the right choice, at the right time, in the right situation.

As the moral law secures freedom, so the law and freedom become the means for grace to ennoble the person to exercise virtue. Examples of virtues include, faith, hope and love, as well as prudence, justice, temperance, and fortitude. Other virtues include patience, compassion, gentleness, self-control, and generosity.

For Christian believers, virtue is the Lords daily call that tells us what to do in his life. There is nothing more tangible and practical in this world than holiness. Virtue is more real than the physical objects of the world, and it shows the world holiness. It helps the human family to see, hear, taste, smell, and touch Gods presence among us.

The person of goodwill, who perhaps has no religious faith, can aspire to freedom and the process of exercising natural virtue in his own interior life. The natural virtues, upon which the Christian virtues flourish, are available and rightly expected of every civil person by their spouse, family, society, culture, and professional association.

As the United States champions freedom, it is a noble action to pause and reflect upon what freedom is. Its worth the time and mental energy to discern a definition and shared understanding of this central cultural idea.

Soldiers have died in defense of freedom. Civil rights leaders have been imprisoned for freedom. People of goodwill have suffered for the cause of freedom.

Each of these sacrifices, and numerous others, reveal to us that freedom is not narcissism. Freedom is not selfishness. Freedom is not about our own small worlds.

Freedom is about human dignity. Its about human flourishing. Freedom is about the common good. Its about selfless service. Freedom is the power to do what is right and noble.

In this way, freedom was (and is) the birthright of those who are a part of the American experiment. Whether this experiment now 244 years old survives or implodes depends upon the willingness of Americans to live their lives according to true freedom and its accompanying virtues.

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Survival of Americas experiment depends on how we use freedom - Crux: Covering all things Catholic

Massive protests in Argentina demand justice and freedom; president Fernandez pledges to end the serial haters – MercoPress

Friday, July 10th 2020 - 09:00 UTC Demonstrators in the Obelisk and in front of Government House. Caravans of cars and pedestrians wave Argentine flags and demand freedom and justice

Thousands took out to the streets in Argentina's capital Buenos Aires and the country's main cities with flags on Thursday, July 9th, Independence Day to protest pandemic restrictions for businesses, corruption, and magistrates decision to send under house arrest one of the most notorious characters of the country's corrupt practices in the awarding of public works contracts.

The massive spontaneous turn out with face masks, but ignoring the quarantine, on its 113th day, probably the longest in the world, and taking advantage on the independence national holiday, cried out for freedom, freedom of expression, freedom to reopen businesses, to re-launch the economy and stop promoting misery, to protect private property, and combating corruption.

Since the quarantine was first established last March, president Alberto Fernandez has ruled with special urgent necessity decrees, while congress remained closed most of the time and similarly with the Judiciary. However this did not prevent some magistrates, loyal to government and allegedly fearful of the pandemic impact, to release notorious characters of the Kirchnerite twelve years, such as ex vice president Amado Boudou, imprisoned for corruption, and now Lazaro Baez.

Mr. Baez has spent four years in jail waiting for a trial and finally is to benefit of house arrest. A former bank cashier in Rio Gallegos in 2003, under the umbrella of then president Nestor Kirchner, Baez rapidly became the main contractor of public works in the Santa Cruz province, later of Patagonia and finally of Argentina. He was believed to be a straw man for president Kirchner.

By the time he was jailed, prosecution discovered he had some 400 properties, distributed in different Argentine provinces, 1,833 vehicles, many vintage, others belonging to his construction companies, and several estancias totaling some 472,000 hectares. His family was also accused of laundering money, at least 60 million dollars to overseas accounts. His assets are estimated in 250 million dollars, and investigators believe there are more to be discovered.

However Baez has now been benefitted with house arrest on bail, but since all his assets are embargoed, his lawyers are trying to negotiate a lower sum, instead of the six million dollars demanded.

Protestors in Buenos Aires marched with flags and sounding horns to the Obelisk and Government House (Pink House), demanding for justice and freedom, and sang the national anthem calling for a true republic. In other cities in the soybean belt protestors demanded respect for private property after one of Argentina's main bean crushers, currently under administration, president Fernandez sponsored by his vice president Cristina Kirchner argued that the best solution was to expropriate the 90-year old complex.

Meanwhile president Fernandez from the presidential residence in Olivos headed the official Independence Day ceremony, standing next to him were provincial governors, leaders from business, industry, finance, agriculture and trade unions.

In a message to the nation Fernandez again underlined that the main purpose of his administration and policies was to preserve the health and life of Argentines above all, even above the economy, and called for the unity of all Argentines.

We've already started to rebuild the Argentina of tomorrow, which we are all building jointly, men and women of industry, agriculture, commerce and finance, said Fernandez, but immediately warned that hate and division, delays and paralyzes us

Finally he underlined that no society can be built or achieve its destiny in the midst of insults, divisions and above all in an atmosphere of hate. I've come here to end with all the serial haters, insisted the Argentine president in what seemed a reply to the thousands that turned out to protest.

The current pandemic extension in Argentina is expected to end next July 17, particularly in metropolitan Buenos Aires, which includes the capital and the neighboring urban rings in the province of Buenos Aires, but given the sustained number of virus contagion cases, there are insistent rumors that a further extension is under consideration. Argentina with a population of 45 million, has reported 90,700 contagion cases and 3,363 deaths.

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Massive protests in Argentina demand justice and freedom; president Fernandez pledges to end the serial haters - MercoPress

MLS is officially back and more: Freedom Kicks for 9 July 2020 – Black And Red United

Hello! MLS is officially back, and there was soccer last night and there is soccer right now. It is still a very open question about whether or not these games should be played, but they are here.

To the links:

Recap: Orlando City SC vs. Inter Miami CF 07/09/2020 | Matchcenter

By all accounts, the first game of the MLS is Back Tournament was a scrappy affair, as one would think after such a long layoff. Nani scored the late winner for the hosts.

The Black Players for Change in MLS protest before first MLS Is Back game

However, the most impactful thing from the game was the protest from the Black Players for Change, in which they took the field with the starting lineups to protest police brutality and advocate for human rights.

Roundtable: Leaders of MLSs Black Players for Change on charting a way forward The Athletic

If you want to learn more about the goals of Black Players for Change, I highly recommend that you read this article.

I knew Adidas contract with the league was big, but I didnt know it was that big.

Here is some wholesome Donovan Pines content for your Thursday morning.

There is a new NWSL team, and I really like their color scheme. Pale purple and mint? Yes, please.

Thats all I have this morning, whats up?

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MLS is officially back and more: Freedom Kicks for 9 July 2020 - Black And Red United

Beefed-up rosters give Cardinals opening to flex versatility, depth of bullpen – STLtoday.com

Cardinals pitcher Kwang Hyun Kim, right, and pitching prospect Johan Oviedo head to the mound during the seventh day of "Summer Camp" at Busch Stadium in St. Louis on Friday, July 10, 2020. Photo by Colter Peterson, cpeterson@post-dispatch.com

Whenever, however he was being used in a game or, in the past few months, throwing bullpens with catcher Yadier Molina in Florida, rookie Junior Fernandez referred to a note he and pitching coach Mike Maddux committed to paper and he committed to using as a compass.

It reminds him regardless of the situation, regardless of the opponent, and regardless of the spot in the game to pitch to his strengths.

Now that Im here Im ready for everything, Fernandez said Friday evening at Busch Stadium. Here you have to be ready for everything any role, any time they call, any time they say youve got to be ready, youve got the next guy. With the plan that I set up, it doesnt matter who I face, doesnt matter what inning I pitch. Im always ready, and I come with the mindset that nobody can hit against me. Pitch with my strengths.

The note gives him direction.

That should help in a shortened season that will start backward and inspire teams to consider reverse-engineering games from the bullpen forward. The 60-game sprint for the postseason starts with a dash of September in July. Rather than end the season with expanded rosters, clubs will begin that way opening with a 30-man roster, as many as 17 pitchers, and handfuls of reasons to go sooner and more often to a deeper bullpen.

Its definitely more backwards than any of us are used to in our game, manager Mike Shildt said. But so are our circumstances. And we adjust and figure it out. I do feel like our ability to understand that weve got a bit more moving parts, with a more abbreviated spring training (makes) sense and literally guys get their legs under them. I feel like our approach is fairly aggressive. With more options, I could see the point of it, allowing for more aggressiveness knowing the next day youre got protection.

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Beefed-up rosters give Cardinals opening to flex versatility, depth of bullpen - STLtoday.com

Hongkongers face a Kafkaesque reality as censors outlaw the words of protest – The Guardian

Writing about the protest movement in Hong Kong, I began to notice the absences everywhere I went. A moving patchwork of white, black and grey squares decorated walls and pavements, as more and more protest slogans were erased from the public gaze. Now, with Beijings enactment of national security legislation in Hong Kong, that void has suddenly gaped wider, swallowing words, ideas, open discussion, and even people from public view.

The legislation bans secession, subversion, terrorism and collusion with foreign forces. The first sight of it for Hongkongers was the moment that it came into effect on Tuesday at 11pm, ahead of the annual 1 July protest march, which itself had been declared illegal.

In one fell swoop, the new law pushed through many of the changes most feared by Hongkongers, by giving mainland legal bodies jurisdiction over some cases inside the territory, allowing the mainland security services to establish offices in the territory, permitting rendition to China and implementing national security education in local schools.

By Thursday night, the government had announced that the most popular protest slogan an eight-character Chinese phrase translating as Liberate Hong Kong, Revolution of our Times violates the legislation as it connotes Hong Kong independence. This phrase has been chanted at every march by almost every attendee. Since that moment, those Chinese characters began disappearing from social media, replaced by initials (GFHG, SDGM), numbers that serve as Cantonese homophones (3639 0242), symbols or geometric representations of the characters. One protest consisted of eight people standing in the street in two groups of four, each holding up a blank piece of paper. In just a few days, those words have already become unspeakable.

By Saturday, Hong Kongs justice secretary, Teresa Cheng, was warning people not to test the national security law by using the slogan. The previous day a 24-year-old man had been charged with inciting secession because his motorbike was adorned with a flag bearing the motto. He was also accused of terrorist acts for driving his bike into a group of policemen.

There are no sources of authority to provide guidance. There are only warnings

Overnight Hong Kongs reality has become Kafkaesque, even Pythonesque, were it not for the real risk of breaking a law that could carry a sentence of life imprisonment. Even the act of alerting Hongkongers to newly illegal acts has become fraught. The government broadcaster, RTHK, used asterisks in its tweets (variously L******* Hong Kong! and Liberate H*** K***!), while the founder of Hong Kong Free Press, Tom Grundy, said he expected legal and bureaucratic terrorism designed to drain the websites resources.

The surrealism was heightened by the police detention of an overjoyed soccer fan suspected of inciting independence after shouting Long live Liverpool! to celebrate the teams Premier League win. He was later released. Among 370 people arrested on 1 July, at least 10 were detained for violating the new legislation, including three women for possessing offensive materials. Among these, it emerged from police photos, was a sticker emblazoned with the word Conscience causing one netizen to comment that in a country without conscience such a sticker surely amounts to secession. The lack of clarity surrounding the offences, combined with such arbitrary application, has left the population dazed. Libraries have already begun pulling books by certain pro-democracy figures from the shelves for review, signalling a looming assault on freedom of information.

In the decade I spent reporting from China, I found that the laws were often less black and white than Id imagined. In covering sensitive stories, we navigated the ambiguity of the shifting grey zone, guided by interviewees who had often spent decades skating on that political thin ice. This is not possible in Hong Kong, where a gigantic black zone has been imposed overnight on what had been a relatively free society. There is no precedent to draw upon, no experts to consult. The fact that no Hong Kong officials not even the chief executive, Carrie Lam had seen the legislation prior to its imposition means there are no sources of authority to provide guidance. There are only warnings.

This law is global in scope, applying to non-residents outside Hong Kong

Fear is the key to its implementation. That fear is real and its working. In the run-up to the laws enactment, some prominent political groups shut down voluntarily. Nathan Law, the territorys youngest lawmaker, who was elected in 2016 and then disqualified on a technicality, announced that he had left Hong Kong.

The national security law compels internet security providers to comply with the authorities requests for information. Now people I know are erasing themselves from view. Facebook pages and Twitter accounts are disappearing, and my phone, which once buzzed incessantly from notifications from Telegram groups, has fallen silent. Friends are asking to move our communications to more secure platforms. Some are even pleading with their contacts to delete all their WhatsApp conversations.

In this digital era when so much of our identity is online, removing your own archive is not just self-censorship, its an act of self-effacement. But many Hongkongers now fear they have no choice but to cancel themselves as an act of survival. This law is global in scope, applying to non-residents outside Hong Kong. This means that any discussion of Hong Kong politics in classrooms, newspapers or parliaments around the world now involves a corollary discussion of risk, particularly if any participants are inside or from Hong Kong.

I wrote a book about the steps taken by Chinas Communist party to erase the collective memory of the Tiananmen Square killings of 4 June 1989, and its success in muting discussion of the anniversary inside China. I never imagined that the party would try to control public discourse inside freewheeling, vibrant Hong Kong. The extraterritorial nature of this legislation poses an assault on language and freedom of speech that is global in nature. To ignore it risks entrenching those absences worldwide.

Louisa Lim is the author of The Peoples Republic of Amnesia: Tiananmen Revisited and a senior lecturer at the University of Melbourne

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Hongkongers face a Kafkaesque reality as censors outlaw the words of protest - The Guardian

Vor bags $110M to move engineered cell therapy into the clinic – FierceBiotech

CAR-T treatments and other immunotherapies have changed the treatment of some blood cancers, but they can target healthy cells as well as cancer cells, causing nasty side effects. Vor Biopharma is working on an engineered stem cell solution, and its raised $110 million to move its lead program into the clinic.

The Cambridge, Massachusetts-based company is developing the treatment, VOR33, for patients with acute myeloid leukemia (AML) whose disease has worsened despite undergoing chemotherapy or a stem cell transplant.

Thats the setting in which a lot of targeted agents are used. The trouble is, a great number of the targeted agents tend to failnot because they are not efficacious, but because the drug is too toxic for the patients bone marrow, Vor CEO Robert Ang told Fierce Biotech.

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The drugs home in on healthy cells as well as cancerous ones because they express the same proteins. This leads to myelosuppression, which means the bone marrow doesnt make enough white blood cells, platelets or red blood cells for the patient to survive, Ang said.

RELATED: Neon CBO Robert Ang jumps ship to take the helm at Vor Biopharma

Vors treatment is made from hematopoietic, or blood-forming, stem cells from healthy donors. The company uses gene editing to get rid of cancer drug targets in those cells that are biologically redundant, which means deleting them doesnt cause any harm. That target is CD33, in the case of VOR33.

Were trying to make the marrow treatment resistant such that the only cells that are expressing CD33 should be cancer cells, Ang said. We should be able to target them much more specifically, while minimizing the collateral damage that typically happens with these drugs.

RELATED: 5AM, JJDC get in on $42M series A round for cell therapy player Vor Biopharma

Vor believes its treatments could boost the reach of targeted therapies by improving their efficacy and increasing the amount of time patients can undergo those treatments.

And thats not all. In addition to protecting these transplants and the blood cells they produce from targeted drugs, Vor thinks its approach could change the way we think about bone marrow transplant.

To some degree, transplants have been relatively decentralized and less controlled A lot of hospitals develop their own unique practices as to what they think works and how to handle cells and process them, Ang said. Our product will be regulated by the FDA, so we will be able to provide controls and the proper manufacturing steps to ensure were making the best quality product for patients.

The series B will push VOR33 into clinical trials in the first half of 2021, a target the companys on track to meet despite the COVID-19 pandemic. And Vor plans to expand its portfolio beyond CD33, starting with an umbrella of targets in the myeloid space, namely in acute myeloid leukemia, myelodysplastic syndromes and related diseases.

But we are also looking beyond that to other cancers where there are similar potentially biologically redundant targets we could pursue, said Ang, who took the companys helm in August 2019.

Since then, Vor has grown from a staff of six to 50, and its about to move into new digs in west Cambridge as it moves VOR33 toward the clinic. Its got the backing of RA Capital Management, Fidelity, 5AM Ventures, Johnson & Johnson Innovation, Osage University Partners, PureTech Health, the Pagliuca Family Office and Alexandria Venture Investments to do it all.

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Vor bags $110M to move engineered cell therapy into the clinic - FierceBiotech

Stem Cell Therapy Market Regulations and Competitive Landscape Outlook – 3rd Watch News

Stem cells are most vital cells found in both humans and non-human animals. Stem cells are also known as centerpiece of regenerative medicine. Regenerative medicines have capability to grow new cells and replace damaged and dead cells. Stem cell is the precursors of all cells in the human body. It has the ability to replicate itself and repair and replace other damaged tissues in the human body. In addition, stem cell based therapies are used in the treatment of several chronic diseases such as cancer and blood disorders.

The global stem cell therapy market is categorized based on various modes of treatment and by therapeutic applications. The treatment segment is further sub-segmented into autologous stem cell therapy and allogeneic stem cell therapy. The application segment includes metabolic diseases, eye diseases, immune system diseases, musculoskeletal disorders, central nervous system disorders, cardiovascular diseases and wounds and injuries.

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Stem Cell Therapy Market, By Treatments:

Allogeneic Stem Cell TherapyAutologous Stem Cell Therapy

Stem Cell Therapy Market, By End Users:

HospitalsAmbulatory Surgical Centers

Stem Cell Therapy Market, By Application:

OncologyCentral Nervous System DiseasesEye DiseasesMusculoskeletal DiseasesWound & InjuriesMetabolic DisordersCardiovascular DisordersImmune System Disorders

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Stem Cell Therapy Market, By Geography:

North AmericaEuropeAsia PacificMiddle East & AfricaLatin America

In terms of geographic, North America dominates the global stem cell therapy market due to increased research activities on stem cells. The U.S. represents the largest market for stem cell therapy followed by Canada in North America. However, Asia is expected to show high growth rates in the next five years in global stem cell therapy market due to increasing population. In addition, increasing government support by providing funds is also supporting in growth of the stem cell therapy market in Asia. China and India are expected to be the fastest growing stem cell therapy markets in Asia.

Key Players in the Stem Cell Therapy Market are:

Chiesi Farmaceutici S.P.A Are:Gamida CellReNeuron Group, plcOsiris Therapeutics, Inc.Stem Cells, Inc.Vericel Corporation.Mesoblast, Ltd.

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Stem Cell Therapy Market Regulations and Competitive Landscape Outlook - 3rd Watch News

Global Musculoskeletal Disorder Stem Cell Therapy Market 2020 by Company, Regions, Type and Application, Forecast to 2025 – Daily Research Chronicles

Global Musculoskeletal Disorder Stem Cell Therapy Market 2020 by Company, Regions, Type and Application, Forecast to 2025 added by Researchstore.biz unveils the current & future growth trends of this business and outlines details regarding the developments of the market. The report analyzes geographies that form a part of the regional spectrum of the global Musculoskeletal Disorder Stem Cell Therapy market. While offering a complete study of the micro and macroeconomic aspects of the market, the report also emphasizes the key driving and restraining forces for this market. The report then sheds light on the supply & demand analysis, contributions by the top players, and market share growth statistics of the industry.

Market Overview:

The report contains an exhaustive analysis of this business space, along with a succinct overview of its various market segments. A basic overview of the Musculoskeletal Disorder Stem Cell Therapy market has been offered with respect to its present position and the industry size, based on revenue and volume. The Global Musculoskeletal Disorder Stem Cell Therapy Market Report has used analytical tools to include accurate research and evaluation data on key industry players and market coverage. Key elements regarding top companies such as their classification, size, profiles, business atmosphere, future, and recent trends, and contact information are featured in the report. Moreover, data concerning growth opportunities for the market across every detailed region is included in the report. The anticipated growth rate expected to be recorded by each region over the estimated years (2020-2025) has also been given within the research report.

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NOTE: This report takes into account the current and future impacts of COVID-19 on this industry and offers you an in-dept analysis of Musculoskeletal Disorder Stem Cell Therapy market.

The report investigates the development, trends, and new entrants in the sector, with elaborate profiles of the leading companies operating in the market, including: Osiris Therapeutics , Medi-post , NuVasive , Takeda (TiGenix)

In market segmentation by types, the report covers: Allogeneic, Autologous

In market segmentation by applications, the report covers the following uses: Muscle disease, Skeletal disease

Providing a brief of the regional landscape:

Regional segmentation: North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), South America (Brazil, Argentina), Middle East& Africa (Saudi Arabia, UAE, Egypt and South Africa)

Moreover, the report talks about the production aspect, product remuneration, the gross margins of the firms manufacturing the product, and the manufacturing of the product. The report includes information about the product consumption volume and the product consumption value has also been given in the global Musculoskeletal Disorder Stem Cell Therapy report. It delivers a detailed understanding of the consumption patterns of the product.

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Global Musculoskeletal Disorder Stem Cell Therapy Market 2020 by Company, Regions, Type and Application, Forecast to 2025 - Daily Research Chronicles

Autologous Stem Cell and Non-Stem Cell Based Therapies Market Professional Survey Report 2026: By Product, Application, Manufacturer, Sales and…

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Marketplace gives detailed Evaluation about all of the Important aspects regarding the marketplace. The analysis on Global Autologous Stem Cell and Non-Stem Cell Based Therapies economy, offers profound insights regarding the Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace covering all of the significant characteristics of the marketplace. In addition, the report offers historical information with prospective prediction over the forecast period. Various critical aspects like market trends, earnings development patterns market stocks and supply and demand are contained in practically all of the market research document for every single business. A number of the vital facets analysed in the report contains market share, creation, key areas, earnings rate in addition to key players.

The analysis of different sections of the Global Autologous Stem Cell and Non-Stem Cell Based Therapies market are also Covered in the study report. Along with this, for the prediction periods conclusion of variables such as market size and the competitive landscape of this sector is assessed in the report. On account of the rising globalization and digitization, there are new tendencies coming to the marketplace daily. The study report provides the detailed analysis of all of these tendencies.

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Additionally, the Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace report also supplies the Latest tendencies in the Global Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace with the assistance of primary in addition to secondary research methods. Also, the analysis report on Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace gives a wide evaluation of the marketplace including market review, manufacturing, manufacturers, dimensions, cost, value, growth rate, earnings, prices, export, consumption, and sales revenue of this Global Autologous Stem Cell and Non-Stem Cell Based Therapies market. On the flip side, the Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace report also studies the industry standing for the prediction period. Nevertheless, this can help to grow the advertising opportunities throughout the world in addition to major market suppliers.

The key players covered in this studyFibrocell Science, Inc.Vericel CorporationDendreon Corporation (Sanpower Group)Caladrius Biosciences, Inc.BrainStorm Cell TherapeuticsRegeneus Ltd.Genzyme CorporationPluristem Therapeutics IncU.S. Stem Cell, IncTiGenix (Takeda)

Market segment by Type, the product can be split intoAutologous Stem Cell TherapyNon-Stem Cell TherapyMarket segment by Application, split intoCancerNeurodegenerative DisordersCardiovascular DiseaseAutoimmune DiseasesOthers

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaJapanMid East & AfricaAustralia

The study objectives of this report are:To analyze global Autologous Stem Cell and Non-Stem Cell Based Therapies status, future forecast, growth opportunity, key market and key players.To present the Autologous Stem Cell and Non-Stem Cell Based Therapies development in North America, Europe, China, Japan, Mid East & Africa and Australia.To strategically profile the key players and comprehensively analyze their development plan and strategies.To define, describe and forecast the market by type, market and key regions.

In this study, the years considered to estimate the market size of Autologous Stem Cell and Non-Stem Cell Based Therapies are as follows:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year 2020 to 2026For the data information by region, company, type and application, 2019 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

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The Autologous Stem Cell and Non-Stem Cell Based Therapies market report provides useful insights for Every established and advanced players throughout the world. Additionally the Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace report provides accurate evaluation for the changing competitive dynamics. This study report includes a whole analysis of future expansion concerning the evaluation of this mentioned prediction interval. The Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace report provides a thorough analysis of the technological advancement prognosis over time to be aware of the industry growth prices. The Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace report also has innovative analysis of the massive number of unique facets which are fostering or functioning in addition to regulating the Autologous Stem Cell and Non-Stem Cell Based Therapies marketplace development.

A systematized methodology can be utilized to create a Study on the Global Autologous Stem Cell and Non-Stem Cell Based Therapies Sector. For the research of economy on the Conditions of study Approaches, these strategies are useful. All of the Information Regarding this Products, makers, vendors, clients and even more is covered in research reports. Various important factors like market trends, earnings Growth patterns market stocks and supply and demand are contained in virtually all The market study report for every single business. Adaptation of fresh thoughts and Accepting the most recent tendencies are a few the causes of virtually any markets growth. The Global Autologous Stem Cell and Non-Stem Cell Based Therapies market research report provides the profound understanding concerning the Areas in which the marketplace is impactful.

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market Professional Survey Report 2026: By Product, Application, Manufacturer, Sales and...

Global Autologous Cell Therapy Market Revenue Outcome, Robust Vendors, and Investment Prospects – 3rd Watch News

Market Research Exploreoffers an exhaustive analysis on the Global Autologous Cell Therapy Market covering diverse significant factors that pose an impact on the current and forthcoming market conditions. The report elaborates on how the Autologous Cell Therapy market has been performing over the last five years at the global and regional levels. It also analyzes expected ups and downs in the market over the next five years. The report assists market players to operate their business wisely. Market scope, establishment, profitability, maturity, and growth prospects are also highlighted in the global Autologous Cell Therapy market report.

The report mainly emphasizes the market rivalry landscape, leading players profiles, segmentation, and industry environments which have been playing an integral role in posing impacts on market structure and profitability. It also includes a precise assessment of market share, size, demand, production, sales, and revenue that help intuit the financial health of the industry. It also illuminates various market dynamics such as changing product values, demand-supply variations, contemporary trends, pricing fluctuations, growth-driving forces, and unstable market conditions.

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Extensive study of crucial Autologous Cell Therapy market segments:

The global Autologous Cell Therapy market has been segmented into a number of various vital segments such as types, applications, and regions. The report evaluates each segment at a minute level in view of its growth prospects, global demand, and current revenue. It also focuses on the segments that are exhibiting exponential growth during the year and help market players in selecting more profitable segments for their Autologous Cell Therapy businesses and precisely determine the actual needs and wants of their customer base.

Global Autologous Cell Therapy Market Competitive Assessment:

Expansive survey of Global Autologous Cell Therapy Market 2020

According to the report findings, the global Autologous Cell Therapy market report is extremely competitive and encouraging leading manufacturers and companies to execute various business and marketing strategies such as M&A activities, brand promotions, product launches, partnerships, and other expansions to perform comfortably in the relentless competition. The report further examines highlights new product developments, innovations, and technology adoptions done by the competitors in order to offer upgraded products and services in the global Autologous Cell Therapy market.

The report also provides a detailed financial assessment of leading market vendors and insights into the competencies and capacities of these companies to assist Autologous Cell Therapy market players for business expansions. The report also deeply analyzes effective product lines offered by various manufacturers and helps other participants to boost the quality of their products. Analysis based on forthcoming challenges and opportunities is also highlighted in the report, which will help Autologous Cell Therapy market players build lucrative strategies and grab all growth opportunities.

Significant Features of the Global Autologous Cell Therapy Market Report:

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Global Autologous Cell Therapy Market Revenue Outcome, Robust Vendors, and Investment Prospects - 3rd Watch News

Stem Cell Therapy Market Outlook, Opportunity, Demand Analysis And Forecast 2020 2026 – Owned

New Jersey, United States,- Latest update on Stem Cell Therapy Market Analysis report published with extensive market research, Stem Cell Therapy Market growth analysis, and forecast by 2026. this report is highly predictive as it holds the overall market analysis of topmost companies into the Stem Cell Therapy industry. With the classified Stem Cell Therapy market research based on various growing regions, this report provides leading players portfolio along with sales, growth, market share, and so on.

The research report of the Stem Cell Therapy market is predicted to accrue a significant remuneration portfolio by the end of the predicted time period. It includes parameters with respect to the Stem Cell Therapy market dynamics incorporating varied driving forces affecting the commercialization graph of this business vertical and risks prevailing in the sphere. In addition, it also speaks about the Stem Cell Therapy Market growth opportunities in the industry.

Stem Cell Therapy Market Report covers the manufacturers data, including shipment, price, revenue, gross profit, interview record, business distribution etc., these data help the consumer know about the competitors better. This report also covers all the regions and countries of the world, which shows a regional development status, including Stem Cell Therapy market size, volume and value, as well as price data.

Stem Cell Therapy Market competition by top Manufacturers:

Stem Cell Therapy Market Classification by Types:

Bytype1

Stem Cell Therapy Market Size by End-user Application:

Byapplication1

Listing a few pointers from the report:

Objective of Stem Cell Therapy Market Report:

Cataloging the competitive terrain of the Stem Cell Therapy market:

Unveiling the geographical penetration of the Stem Cell Therapy market:

The report of the Stem Cell Therapy market is an in-depth analysis of the business vertical projected to record a commendable annual growth rate over the estimated time period. It also comprises of a precise evaluation of the dynamics related to this marketplace. The purpose of the Stem Cell Therapy Market report is to provide important information related to the industry deliverables such as market size, valuation forecast, sales volume, etc.

Major Highlights from Table of contents are listed below for quick look up into Stem Cell Therapy Market report

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Stem Cell Therapy Market Outlook, Opportunity, Demand Analysis And Forecast 2020 2026 - Owned

COVID-19 Impact and Recovery Analysis on Cell Freezing Media for Cell Therapy Market 2020-2026 by BioLife Solutions, Akron Biotechnology, GE…

Heres recently issued report on the Global Cell Freezing Media for Cell Therapy Market that allows you to offer a brief analysis of the market size, demand, supply chain, distribution channels, futuristic trends, market growth elements and so on. It offers a comprehensive analysis of assorted business aspects like global Cell Freezing Media for Cell Therapy market trends, recent technological advancements, market shares, size and new innovations. What is more, this analytical knowledge has been compiled through knowledge searching techniques like primary and secondary analysis for Cell Freezing Media for Cell Therapy industry. Moreover, an professional team of researchers throws lightweight on numerous static additionally as dynamic aspects of the worldwide Cell Freezing Media for Cell Therapy market.

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Geographically, the worldwide Cell Freezing Media for Cell Therapy market has been analyzed in numerous regions like North America, geographical region, geographical region, Asia-Pacific, Africa, Europe and Asian nation. The worldwide Cell Freezing Media for Cell Therapy market region is dominating this market among the forthcoming future. Worldwide Cell Freezing Media for Cell Therapy market is that the skilled and correct study of assorted business views like key players, key geographies, divers, restraints, opportunities and challenges. This global analysis report has been mass on the concept of assorted market segments and sub-segments associated with the worldwide market.

Global Cell Freezing Media for Cell Therapy market competition by prime manufacturers, with Cell Freezing Media for Cell Therapy sales volume, value (USD/Unit), revenue (Million USD) and market share for each manufacturer. The report provides an in-depth analysis of the worldwide Cell Freezing Media for Cell Therapy Market progressing to cut back time to plug for products and services, cut back operational value, improve accuracy and operational performance. Besides this, the report elaborates crucial aspects such as fresh product establishment, greater expenditure in R&D and increasing demand in the manufacturing differentiable growth opportunities in the Cell Freezing Media for Cell Therapy Market globally.

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The complete profile of the manufacturers are mentioned. And so the capability, production, price, revenue, cost, gross, margin of profit, sales volume, sales revenue, consumption, rate of growth, import and export, future strategies and therefore the technological developments that they are creating are also enclosed among the report. The historical knowledge and forecast knowledge from 2020 to 2026.

Leading companies reviewed in the Cell Freezing Media for Cell Therapy report are:

BioLife SolutionsAkron BiotechnologyGE HealthcareThermo Fisher ScientificBiological IndustriesMerckWAK-Chemie MedicalZenoaq

The Cell Freezing Media for Cell Therapy Market report is segmented into following categories:

The Cell Freezing Media for Cell Therapy market report is segmented into Type by following categories;With FBSWithout FBS

The Cell Freezing Media for Cell Therapy market report is segmented into Application by following categories;Human Embryonic Stem CellsCAR-T Cell TherapyNeural Stem Cell TherapyMesenchymal Stem Cell TherapyHematopoietic Stem Cell TransplantationOther

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The report provides substantial knowledge relating to the market share that every one in every of these firms presently garner across this business, in tandem with the market share that they are expected to amass by the highest of the forecast period. Also, the report elaborates on details regarding the products manufactured by every of these companies, that may facilitate new entrants and outstanding stakeholders work on their competition and strategy portfolios. To not mention, their decision-making method is vulnerable to get easier on account of the actual fact that the Cell Freezing Media for Cell Therapy System market report additionally enumerates a gist of the products value trends and so the profit margins of each firm among the industry.

This will enable the readers to focus on Cell Freezing Media for Cell Therapy market product specifications, current competitive manufacturers in Cell Freezing Media for Cell Therapy market and also the market revenue with gain. Worldwide Industry Analyze Cell Freezing Media for Cell Therapy Market by competitive manufacturers, regions and applications of Cell Freezing Media for Cell Therapy market, forecast up to 2026. This report analyses the scope of Cell Freezing Media for Cell Therapy market. This will be achieved by Cell Freezing Media for Cell Therapy previous historical information, analysing qualitative insights info, demonstrable projections regarding global Cell Freezing Media for Cell Therapy market size.

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COVID-19 Impact and Recovery Analysis on Cell Freezing Media for Cell Therapy Market 2020-2026 by BioLife Solutions, Akron Biotechnology, GE...

13 promising Covid-19 treatments emerging from Israel – The Yucatan Times

In parallel to vaccine research, theres an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus.

ISRAEL (Scientists across the globe are working on vaccines to prevent Covid-19 infection. After initial vaccines are approved, there is an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus.

Most potential treatments target the life-threatening lung inflammation typical of covid-19 severe cases. Its caused by a phenomenon called a cytokine storm.

Cytokines are proteins that trigger inflammation as a natural response to infection. In response to a virus overload, in this case, in the lungs, the immune system activates a storm of cytokines. Too many cytokines lead to too much inflammation, which can damage the lungs and cause respiratory distress.

Israeli hospitals were among the first anywhere to use dexamethasone, a steroid drug, to stop cytokines storms and reduce lung inflammation in severely ill Covid-19 patients. However, steroids can suppress the immune response too actively.

Additionally, an Israeli hospital is among the first to do a randomized, double-blind, placebo-controlled clinical trial of ivermectin, a drug to treat parasitic infections in people and animals, to see if it can shorten the duration of the disease if given to Covid-19 patients immediately after diagnosis.

Israelis are also formulating novel therapeutics of their own. Here are 13 potential Israeli treatments using a variety of approaches.

PluristemOn June 11, Pluristem Therapeutics of Haifa announced a multicenter Phase 2 US Food and Drug Administration (FDA) efficacy and safety study of its PLX-PAD cells for treating severe Covid-19 complicated by acute respiratory distress syndrome (ARDS).

PLX, an injected regenerative placenta-derived cell therapy, stimulates the immune systems natural regulatory T cells and M2 macrophages, possibly preventing or reversing a cytokine storm. PLX cells potentially reduce the incidence or severity of Covid-19 pneumonia and pneumonitis.

Pluristem has treated Covid-19 patients under compassionate use programs in the United States and Israel. Initial data from 18 patients showed that 75% were off mechanical ventilation within 28 days.

PLX cells are available off-the-shelf and once commercialized, can be manufactured in large-scale quantities, offering a key advantage in addressing a global pandemic, the company said.

SilkimJerusalem-based Silkim Pharma recently submitted Coronzot, its novel treatment for Covid-19 patients with moderate to severe symptoms, to the FDAs Investigational New Drug (IND) program.

IND designation would give Silkim permission to start human clinical trials and ship Coronzot across state lines before a marketing application has been approved.

Coronzots novel mechanism targets a pivotal factor in cytokine storms. It removes an inflammatory overaccumulation of labile iron and replaces it with a minute amount of gallium or zinc.

This not only suppresses the storm but also inhibits viral proteins that attack the lungs and heart. Gallium inhibits virus replication and promotes apoptosis (self-destruction) of already invaded cells. Zinc helps suppress inflammatory reactions and enzymes that enable coronavirus replication.

The company is actively engaged in the FDA process. We look forward to finalizing the IND and then moving towards conducting clinical studies of Coronzot for Covid-19, said Silkim Pharma CEO Dror Chevion.

RedHill BiopharmaRedHill Biopharma, based in Raleigh, North Carolina, and Tel Aviv, is racing to advance our development program with opaganib for Covid-19, according to a June 10 statement by Dr. Mark L. Levitt, RedHill medical director.

RedHill acquired opaganib from US-based Apogee Biotechnology, which developed this oral drug to fight cancer, inflammation, and viruses.

RedHill has seen encouraging preliminary findings from six Israeli Covid-19 patients given opaganib under compassionate use to reduce lung inflammation. All were weaned from supplemental oxygen and discharged from the hospital without having to receive mechanical ventilation.

RedHill plans a multicenter, randomized, double-blind, parallel-arm, placebo-controlled Phase 2/3 clinical study on 270 US patients with severe Covid-19 pneumonia.

We are expanding the development program to Russia and additional European countries, parallel with the US clinical study, to accelerate the collection of robust data on the potential efficacy of opaganib against Covid-19, said Levitt.

The company is working with government agencies worldwide to allow more patients access to the investigational drug through clinical studies and compassionate use programs.

InnoCanInnoCan founders, from left, Ron Mayron, Iris Bincovich, Yoram Drucker. Photo by Rotem LahavInnoCan Pharma Israel and Tel Aviv University tech-transfer company Ramot are collaborating to develop a new CBD-loaded exosome technology to fight lung inflammation.

Exosomes, small particles created from stem cells, can act as homing missiles targeting specific damaged organs and facilitating cell-to-cell communication.

Combining the cell-healing properties of exosomes with the anti-inflammatory properties of the cannabis-derived compound CBD is expected to have a strong synergetic effect. The treatment is administrated by inhalation.

Stero BiotechsStero Biotechs of Bnei Brak has started a small clinical trial at Rabin Medical Center in Petah Tikva on the tolerability, safety, and efficacy of CBD-enhanced steroid treatment for hospitalized Covid-19 patients.

Steroid treatment is usually the first or second line of treatment for hospitalized patients. CBD enhances the therapeutic effect of steroid treatment and treats the bio-mechanism affected by the virus, the company explained.

Eybna and CannaSoulTwo Israeli cannabis R & D firms, Eybna Technologies and CannaSoul Analytics, develop a proprietary terpene formulation for modulating cytokine storms.

Terpenes are organic compounds found in cannabis and other plants. Studies suggest they can be effective antiviral agents.

CannaSouls Cytokine Storm Assay (from its Myplant-Bio subsidiary) will aid in optimizing and customizing Eybnas novel NT-VRL inhaled formulation for treatment and prevention of viral infections in high-risk populations and actively ill patients.

The FDA considers this assay as a good predictor for cytokine storm response and immunotoxicity, and it is commonly required in the development of biological treatments, according to CannaSoul Chairman and CSO Prof. Dedi Meiri.

The NT-VRL formulation intended to be used via inhalation, said Eybna CEO Nadav Eyal. This delivery method dramatically increases the terpenes bioavailability by directly contacting the infected cells in the respiratory system.

CannaSoul aims to identify other cannabis molecules capable of suppressing a cytokine storm in response to Covid-19 without completely suppressing the immune system. It is also studying how cannabis molecules could modulate the ACE2 receptor, which allows the virus to inject its genetic expression into human cells.

KamadaBased in Rehovot, Kamada has begun supplying its experimental plasma-derived Hyperimmune IgG therapy for compassionate use in severe Covid-19 cases in Israel.

The treatment is based on plasma donated by recovered Israeli Covid-19 patients. One critically ill patient at Hadassah Medical Center showed initial improvement after having the experimental IgG therapy but ultimately did not survive.

During the third quarter of this year, Kamada expects to start a Phase 1/2 clinical study in hospitalized Covid-19 patients in Israel and hold a pre-IND meeting with the FDA to expand clinical development in the United States in partnership with Kedrion Biopharma.

Kedrion is collecting plasma from recovered American Covid-19 patients at 23 FDA-approved centers across the United States. This will be used by Kamada to manufacture additional batches of the product.

To the best of our knowledge, Kamada is the first company globally to complete manufacturing of a plasma-derived IgG product for the treatment of Covid-19, said Kamada CEO Amir London.

Israel Institute for Biological ResearchThe government-run Israel Institute for Biological Research (IIBR) announced in May that analogs of two drugs for Gauchers disease proved effective against SARS-CoV-2.

This drug cocktail is made up of the FDA-approved Cerdelga and an analog of the second drug in advanced stages of the approval process.

The IIBR study on cell cultures demonstrated that the two-drug treatment significantly reduced the coronaviruss replication capacity and the destruction of the infected cell. This potential treatment is currently being tested in animals infected with the coronavirus.

The IIRB also isolated several critical coronavirus antibodies that successfully neutralized aggressive coronavirus in lab tests. These could form the basis of future treatment following further testing.

PepticomBased in Jerusalem, Pepticom computationally designs novel peptide drug candidates using artificial intelligence. The company raised $5 million last year.

Three months ago, Pepticom began implementing its proprietary AI technology on various coronavirus proteins to identify novel peptides that inhibit the interaction between the spike protein of SARS-Cov-2 and the ACE2 receptor thereby stopping the virus from entering the cell.

CEO Immanuel Lerner says three such proteins have already been identified and are being validated in the lab.

Using AI is a fast way to find these peptides, which are less expensive and easier to produce than antibodies, Lerner tells ISRAEL21c. Many parties are interested in looking at our results and finding ways to develop this further.

Bonus BioGroupIn April, Bonus BioGroup initiated a preclinical study of MesenCure, its unique drug for treating acute and life-threatening respiratory distress in coronavirus and pneumonia patients.

MesenCure consists of activated mesenchymal stromal (stem) cells from healthy adult donors. The activation of these MSCs is intended to boost their ability to reduce lung inflammation, promote regeneration of the diseased lung tissue, and alleviate respiratory and other symptoms in the lungs.

The development of MesenCure relies on more than a decade of related experience and technologies that Bonus BioGroup has used in developing its lead product, a tissue-engineered bone graft, also based on MSCs.

With the current coronavirus outbreak, Bonus BioGroup has started tissue culture studies into the potential of these MSCs, further activated, to alleviate inflammation, including in the lungs, and possibly attenuate the cytokine storm in COVID-19 patients, the company explained.

The preclinical study in several animal models is expected to be completed in the third quarter of 2020. The company said preliminary results indicate that following the treatment with MesenCure, the microscopic appearance of the treated lungs was similar to a healthy lung, and a significant improvement in additional related parameters was achieved.

Bonus BioGroup presented these results to 1,800 scientists, physicians, and public opinion leaders at the International Society for Cell & Gene Therapy virtual conference in May.

NanoGhostTechnion-Israel Institute of Technology Prof. Marcelle Machluf developed a drug-delivery technology that uses reconstructed mesenchymal stem cells as nano-vesicles to transport medicine directly to a target.

NanoGhost is the startup she established to commercialize the technology, which has proven successful in treating pancreatic, lung, breast, prostate, and brain cancer in mice. The NanoGhost technology has been patented in the United States and Europe, with additional patents pending in India and China.

Now, Machluf is adapting her technology to create decoy NanoGhosts that attract and entrap the coronavirus, making for a less severe infection. She explains it in the video below.

EnlivexEnlivex Therapeutics of Ness Ziona is developing Allocetra, a novel immunotherapy medication to treat organ dysfunction and acute multiple organ failure associated with sepsis and Covid-19, as well as solid tumors.

Allocetra rebalances a severely unbalanced immune system by engaging with the immune systems own regulation mechanisms. It is designed to restore a safe immune balance following a cytokine storm.

Enlivex is starting to recruit Covid-19 patients in Israel and in the United States to test the potential effect of Allocetra on moderate to severe cases. A patent from the Japan Patent Office is expected during the third quarter of 2020.

Weizmann Institute of ScienceOrganic chemist Nir London of the Weizmann Institute of Science in Rehovot is co-leading a collaborative project to identify small molecules that can bind to and inhibit a protease enzyme that the SARS-CoV-2 virus needs to reproduce.

London and his research team had previously developed an advanced method for identifying potential inhibitors for numerous proteins.

So far, we have made close to 800 compounds and tested more than 650 and keep getting closer to sufficiently potent inhibitors, London tells ISRAEL21c.

These inhibitors will be further investigated for their potential as a starting point for new drugs against the coronavirus.

London is working with researchers from Oxford University, Memorial Sloan Kettering Cancer Center, University of British Columbia, and Californian-based biotech company.

The Yucatan TimesNewsroom

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13 promising Covid-19 treatments emerging from Israel - The Yucatan Times

Rowdy Teens Prompt Curfew In Toms River Beach Communities – Toms River, NJ Patch

TOMS RIVER, NJ Beginning Thursday night, kids under the age of 18 will have to be off the streets in Toms River's barrier island beach communities from 9 p.m. to 5 a.m. under an order issued by the Toms River authorities.

The curfew has been instituted in response to continuing problems with kids gathering in large groups in those communities and vandalizing property and causing other problems, said Jillian Messina, media relations specialist with the Toms River Police Department.

"Residents have reported increasing problems with unruly juveniles congregating nightly in violation of the social distancing and face mask restrictions imposed by the governor's executive order, and also committing acts of criminal mischief and other disorderly behavior," Messina said, quoting an emergency order issued by the township's Office of Emergency Management and the police department.

The incidents have been happening in the North Beach area on the barrier island, which includes Silver Beach, Monterey, Normandy Beach, Chadwick Beach and Ocean Beaches 1, 2 and 3.

The incidents have been happening since early June, Messina said, and have continued despite warnings from the police department for parents to not drop off kids at random in the communities. Read more: Keep Kids Home, Toms River Police Warn, After Property Damage

"While we understand these are difficult times and children are frustrated with the lack of open activities, it is not an excuse for misbehavior and disrespect within our community," Messina said.

The curfew prohibits anyone 17 or younger from being on "a public street, avenue, boulevard, place, walkway, alley, park, or any public area or unimproved private property located in the North Beach area of the Township between 9 p.m. and 5 a.m., unless accompanied by a parent or legal guardian," according to the order.

Messina said the goal has been "to educate our community, especially parents."

Kids who are out in violation fo the curfew will be told to go home, she said. Those who refuse to follow the curfew "may be taken into protective custody and returned to their homes with charges pending.

"When violations are egregious, they may be taken into custody and brought to headquarters where complaints will be signed and a parent or a guardian will have to respond to pick them up after processing," she said.

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Rowdy Teens Prompt Curfew In Toms River Beach Communities - Toms River, NJ Patch

Mass publishing has a history of coping with pandemics. After all, it was born of one – Scroll.in

In October 1347, a fleet of trading ships docked at the Sicilian port of Messina. People gathered on the docks were in for a nasty surprise when they went on board. Most of the sailors aboard the ships were dead. Those still alive were mysteriously ill and covered in black boils that oozed blood and pus. Aghast, Sicilian authorities hastily ordered the death ships out of the harbour and back to their origins in the Black Sea, but it was too late.

Over the next five years, the Black Death (more mundanely known as the bubonic plague) would dart across Europe, leaving a trail of death in its wake and wiping out almost one-third of the continents population. It didnt entirely disappear until the beginning of the seventeenth century. And yet, despite its murderous effect, the Black Death was the making of modern Europe.

It played a central role in the advent of new population controls, in the establishment of universities, the spread of Christianity, the dissemination of vernacular culture, and even the rise of nationalism. In Italy alone, the Black Death marked the end of an era and the emergence of the Renaissance: that golden period of art, architecture and literature in human history.

Pulling this new narrative in politics, religion and socio-economic change together was a common thread, spun by the hand of a German goldsmith named Johannes Gutenberg. The story of Gutenberg and his printing press, and the veritable revolution of ideas it caused in the 1400s, not just across Europe, but across the world is one that most of us know. Within decades, the worlds nascent publishing industry had accommodated itself to the new world and to a new class of readers.

Initial books were copied in long-form, manuscript style, to initiate the new reader slowly. Paper went from being manufactured from sheepskin (parchment) or calfskin (vellum) to being made out of leftover rags, slashing its costs in half. In the 1480s, a savvy Venetian printer by the name of Andre Manutius decided to compress the size of an average book giving birth to the 15th centurys version of the modern e-book, the pocket book. By 1604, to cope with the increasing complexities of social, economic and political upheaval, the first weekly newspapers (then quaintly called news-books) came into being in Europe.

The Black Death was not the first pandemic in the world, nor would it be the last. Regular outbreaks of disease across the globe have felled people in their scores, but they have not surprisingly slowed or extinguished the publishing industry. In his excellent account of the Black Death, the historian Philip Ziegler writes, Painful readjustment, demoralisation, lawlessness: such are the familiar symptoms of a society recovering from the shock of the plague.

While this is undeniably true, a glance across the pages of history informs the curious that despite death, loss and unspeakable fear, the human mind has never lost its quest to learn. Publishing houses across the ages have stood as testament to this fact. In 1534, King Henry VIII established Cambridge University Press, giving it carte blanche to print any manner of books.

The Press still stands today, with the distinction of being the worlds oldest publishing house. It has weathered technological changes, two global wars, repeated pandemics from recurrences of the plague to the Spanish flu, from the Asian flu to Ebola and H1N1 and social and economic turmoil to continue producing not just religious texts, but also academic tracts spanning a wide range of subjects.

Theirs is just one example of the hundreds of publishing houses that sprang up in the wake of Gutenbergs press. By 1482, there were 100 printing presses in Europe alone. By 1500, about 40,000 different editions were circulating in the European market, which came up to a total of 6,000,000 copies in print. It wasnt long before the press had found its way to other continents, revolutionising the way people thought.

In 1556, a Portuguese ship docked in Goa, India. Aboard were 14 Jesuit priests bound for Abyssinia (Ethiopia on todays map), and a printing press. The press made landfall in India after the awed clergy in Goa made the impassioned plea that they needed it more than the Abyssinians. It didnt catch on, however, until 1706 when the Dutch reached India. A missionary with the awe-inspiring name of Bartholomew Zeigenbalg insisted that for his work, he needed the printing press. And so it was that the first printing press began functioning in Tharangambadi (Tranquebar) in Madras.

Todays testament to this historic moment is the Tranquebar imprint, owned by Westland Books in India. Now, it wasnt to be expected that this delightful new medium of disseminating information and making some money would function in a void. The next step, quite obviously, were bookshops. The explosion of printing presses and the resultant flood of books and information into an eager market was fertile soil for anyone wanting to trade in books.

In 1887, Elkin Mathews and John Lane set up The Bodley Head, to trade in antiquarian books in London. The bookshop survived the Great War and in 1919, it was taken over by Lanes nephew, Allen. Lanes ideas were dynamic enough to terrify the staid board of directors at The Bodley Head. Against the backdrop of the Great War, and another pandemic this time, the deadly Spanish flu Allen Lane pushed for the expansion of The Bodley Head into newer, more dynamic realms of publishing fiction, for instance. Part of his enthusiasm came from the remarkable momentum in publishing across the Channel, and part from the United States of America.

The United States had been hit badly by the Spanish flu. Nearly 50 million people had died across the country by the time the pandemic petered out, but as people grappled with questions of life and death, and larger, more political ideas such as fascism and imperialism, literature became a chosen outlet. In 1914, as the world went to war, Margaret Anderson began The Little Review.

It was supposed to be a literary journal, carrying poetry and prose themed around feminism and anarchism. But in the fifteen years that it ran (it finally ended its print run in 1929), The Little Review stood as an example to prove that events of catastrophic import a war, say, or a pandemic were hard drivers for both increased learning and the kind of change that a society sought at that moment in time.

Andersons key aides were Jane Heap, her business partner, publisher and lover, and the critic and poet Ezra Pound. Between the three of them, they built The Little Review into one of modern literatures most controversial and elite platforms. Everyone from Ernest Hemingway to TS Eliot and WB Yeats was published in The Little Review, which once daringly brought out an entirely blank issue, to condemn the lack of exciting new literature to review and critique. Yet another example of how publishing has, in its own way, been a beacon for the kind of revolution that society has sought from time to time.

Between 1918 and 1920, The Little Review serialised James Joyces Ulysses, with the final episode ending on Joyces 40th birthday. The world may have been reeling with a virus nobody could understand, but it still appreciated good story-telling. So much so that it caught the eye of a young woman in Paris.

Sylvia Beach her real name was Nancy Woodbridge Beach was a young student of French contemporary literature in Paris, when she met the woman who would become her lover and the inspiration for the iconic Shakespeare and Company. The bookshop was set up in November 1919, and soon became the celebrated haunt of writers like F Scott Fitzgerald, Mina Loy and Gertrude Stein. In 1922, Beach scandalised and tantalised Parisian society by publishing Ulysses.

Her avant-garde attitude to life and literature charmed Allen Lane. By the end of the Great War, the Spanish flu had appeared in Britain as well. Lane insisted that The Bodley Head step away from its specialty trade of antiquarian books into newer waters. Penguin Books would become Lanes new imprint, and under its emblem, James Joyces saga found a home in England. There was no looking back for Lane and his newborn publishing house after that, which became a monolith in the publishing industry in the twentieth century.

Allen Lane wasnt the only one who foresaw a future in publishing. There were those who looked beyond the borders of England to its teeming colonies in the East. India and China, in particular, were popular with the burgeoning publishing industry, from the end of the 19th and well into the 20th century. The choice of India was made to nurture a growing market, developed earlier by the introduction of English education by Lord Macaulay in 1835.

Longman Green set up shop in 1895, while MacMillan and Oxford University Press (OUP) opened offices in Bombay in 1912. For OUP, at least, its arrival in India was equivalent to its rebirth. In the early years of the twentieth century, OUP, the worlds second oldest publishing house, was tottering on the verge of collapse. It had become a press that had increasingly come to embody carelessness (glaring errors and typos were a stock in trade for OUP), bureaucratic decay and corruption. It was largely alive due to its leasing of its printed Bibles and prayer-books.

Its managers at the time, of whom Rieu was one, were uncomfortably aware that in order to survive at all, OUP would have to diversify. Directors at OUP had earlier entered into a joint venture with Hodder and Stoughton to expand into education, science, medicine and fiction. Now, they looked eastwards.

In 1911, then, the British poet, classicist, publisher and translator, Emile Victor Rieu boarded the Trans-Siberian Railway. He was bound first for Shanghai, where OUP wanted its agent sacked for poor service. His next, more, permanent port of call was Bombay. From its first office on Hornby Road, Rieu focused on the advantage that Macaulays Minutes had given OUP, by working to expand business in the area of school textbooks. Indeed, one of the first academic books OUP published at this point was The Essentials of Psychology, written by a young unknown, by the name of Sarvepalli Radhakrishnan. Then, the world went to war.

In India, the first effects that OUP felt were delays and disruptions in shipping. Paper shortages were next, followed by a disastrous non-delivery of important electrotype and stereotype plates that were required for printing. This was topped by a dire lack of hands as the staff were called up to serve on battlefronts across the world. Still, OUP persevered and in 1915, it secured a crucial contract to print textbooks for schools in the Central Provinces.

The contract kept OUP afloat for the duration of the war, and just as well, because by 1917, Rieu couldnt put off his enlistment any longer. He went to war, leaving OUP in the hands of his wife, Nellie, herself the editor of the British literary journal, Athenaeum. She managed by taking orders to print political propaganda for the Government of India. At one point, OUPs non-governmental printing in India was down to a meagre thirty pages. But it held on.

In the aftermath of the war, the Spanish flu visited India, killing millions. Rieu himself returned, having been struck by illness in the midst of action. His most pressing problem (aside, of course, from his recovery) was to relocate OUPs offices immediately. Even despite the war, and the flu, OUP had outgrown its space on Hornby Road. A new space was found on Elphinstone Circle (Horniman Circle, in modern Mumbai): big enough to hold new stocks of books, and an indolent cow that refused to move.

Over the years, OUP has continued to survive, adapting itself to the changing political climate and social needs of the continent with remarkable ease. By the late 1920s, OUPs stock inventories in Madras, Calcutta and Bombay were sizeable and trade was flourishing. It also began putting forth feelers across East and Southeast Asia, in North America and in South America. Today, of course, Oxford University Press is synonymous with more serious works of non-fiction, of education, medicine, history and science: yet another testament to the human ingenuity that is at the heart of the publishing world.

There are innumerable examples from the world of publishing both in terms of big houses and smaller initiatives that stand out against the backdrop of unspeakable strife. Wars, pandemics, global depressions: each a defining crossroads in human history; each with the ability to change life as we know it forever. And yet, the power of the written word transcends disaster of any kind, in its ability to adapt, to survive, to question and to persist.

This series of articles on the impact of the coronavirus pandemic on publishing is curated by Kanishka Gupta.

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Mass publishing has a history of coping with pandemics. After all, it was born of one - Scroll.in

Tech Stocks Have Been the Markets Stars. Are They Overbought? – Barron’s

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Like an Escher drawing hanging in a students dorm room, the stock market has begun to look rational and irrational simultaneously. Nowhere is that more obvious than in the Nasdaq Composite.

The tech-heavy index has gained 18% this year, after practically ignoring the explosion of Covid-19 cases in places like Florida and Texas. It ended the week with three consecutive highs, and for good reason: The index is composed of the kinds of companies that can not only survive, but thrive, in a world where going about your normal, everyday business could get you sick.

Yet there comes a point when even the soundest argument starts to sound specious, even to those making it, and that seems to be what is happening now. Deutsche Bank analyst Jeriel Ong went on record with his worries about Apples (ticker: AAPL) rally, yet left his Buy rating intact and raised his price target to $400 from $380. Others warn that the big tech stocks are getting expensive and crowded, yet see no alternative when future economic growthand corporate profitscould be impaired. I compare the current environment to the Twilight Zone, says Ed Yardeni of Yardeni Research. There are so many possible ways this could go.

For now, though, it seems to only go upand there may be more to this than fundamental strength. Chris Harvey, U.S. equity strategist at Wells Fargo Securities, notes that when the Russell 1000 Growth index was rebalanced on June 26, the combined share of Apple, Microsoft (MSFT), and Amazon.com (AMZN) rose from 25.3% of the index to 28.6%. Just getting to an index weight required a lot of buyingand most active mutual-fund managers were underweight. With those stocks among the years best performers, it meant managers would underperform the growth index by even more unless they started buying.

While the shift toward the biggest techs is most pronounced in the Russell 1000, most indexes are seeing the same. At Thursdays close, technology made up 28% of the S&P 500, up from 21.5% on Nov. 8, 2016, when the Real Estate sector debuted. The Communications Services sector, which includes Facebook (FB), Alphabet (GOOGL), and Netflix (NFLX), has increased to 11.1% from 2.5%.

Economically sensitive sectors have stayed about the same, and are largely immaterialmaterials, utilities, and real estate have 2.5%, 3%, and 2.8% weightings, respectivelyor seen their shares decline. Energy has fallen from a 7.2% weighting to 2.5%, while Financials have dipped to 9.7% from 13.4%.

A friend wondered only half-jokingly how long it would take for the SPDR S&P 500 exchange-traded fund (SPY) to have the same weightings as the Invesco QQQ ETF (QQQ), which tracks the Nasdaq 100. But it is also clear how reliant the market is on the tech stocks in the Nasdaq for further gainsand how that could lead to future losses. Its a conundrum for investors, who know they are in the same trade together, says Nordea strategist Sebastien Galy.

Like it or not, were all tech investors now.

Write to Ben Levisohn at Ben.Levisohn@barrons.com

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Tech Stocks Have Been the Markets Stars. Are They Overbought? - Barron's

Stock market rising on the indispensable companies – Minneapolis Star Tribune

The boomers and Xers remember when Microsoft was so dominant that a federal judge ordered it broken up.

That year of peak Microsoft was 2000, the tail end of the dot-com boom. While the company stayed in one piece and moved on, 10 years later its stock price was nowhere near its peak. It became easy to never think of Microsoft except maybe when upgrading to the new Office software suite.

But, of course, peak Microsoft really came last week.

Its also the era of peak Apple, peak Amazon.com and peak Netflix.

These companies are worth so much in the stock market now that their big year has become one explanation for a booming stock market rally since March, when a sharp downturn due to the coronavirus pandemic reversed course.

This might not be a stock market story, either, explained away by factors like bored sports bettors looking for a new way to squander their money. Maybe instead we are seeing more value in companies that provide the stuff that turned out to be essential as the COVID-19 pandemic rolls on, and maybe even well after it winds down.

Microsoft often seems surprising on a list of high-flyers, because it must be well into its sleepy, late middle age by now, right? It has been a quarter-century since release of its groundbreaking Windows 95 operating system for personal computers.

After months of ignoring news of its resurgence, it took less than an hour of reading to see its a genuine powerhouse. It provides an array of software and services that form part of the basic foundation for business, stepping into the kind of role once played by International Business Machines Corp.

Microsoft reported revenue of about $35 billion in its last quarter, up 15% from the prior years quarter, with an operating margin of better than 37%. It generated cash flow from operations in just those three months of $17.5 billion.

Microsoft has been battling for top spot among Americas most valuable companies with Amazon and Apple. Yet because of the structure of its ownership, Microsoft is the biggest factor now in how well the S&P 500 performs and thus our perception of the stock market.

The S&P 500 is a weighted index, so the relative value of the components matters a lot. The heavyweight champ Microsoft outweighs the top 10 Minnesota-based companies, combined as a group, by more than two to one.

Take a Minnesota blue-chipper like Target, a corporate stalwart thats a big part of the states economy. Microsoft has more than 25 times the impact of Target in the S&P 500. Microsoft shares go up in price 5%, and that could be enough to make it a good day in the stock market. Target stock goes up 5% and the needle may not budge.

Valuable, not overvalued

This isnt just a Microsoft story, either. Microsoft stocks strong appreciation this year has trailed Netflix and Amazon. As of last week, just six big technology companies now make up about a quarter of the S&P 500.

These big technology companies are still not wildly overvalued, at least according to strategist Jim Paulsen from the Minneapolis-based Leuthold Group, nothing like technology firms were during the frenzied speculation that powered Microsoft (and even a few comically speculative startups) to new highs 20 years ago.

Moreover, he explained, the professional investors are buying them now because they appear safer to own in a really stressful time, kind of like how fund managers bought the stock of utilities or food companies in an earlier era. As he put it, The rally in tech and new-era is being driven at least in part by bearishness and fear.

What made those old-fashioned defensive companies attractive in a sinking economy is that their businesses held up better because nobody voluntarily cut off their own electric power or quit buying groceries. These things are indispensable.

And thats the word that Gene Munster, analyst and co-founder of venture firm Loup Ventures in Minneapolis, used to describe the tools and products that companies like Microsoft and Apple now sell.

You may not love these companies, their market dominance and hubris, but they do really deliver. Social isolation and working from home made Apples iPhones and iPads as important as a working refrigerator. Need a computer mouse right away because a teenager borrowed one that then went missing? Try Amazon.com.

There are competitors in streaming video including Apple and Walt Disney Co., but Netflix is the cant-miss place for entertainment this year.

Last weekend our family used Netflix to watch a new movie about a comically bad Icelandic musical duo. The movie was fine, but what made this a memorable evening was how five family members could watch one movie together, chatting away, from four different living rooms.

I dont know how much Netflix would have to raise its price to get me to cancel.

Whats essential?

Facebook has been another strong performer of late, yet Munster called it an outlier to his notion of the top firms providing essential services.

Hes not referring to the swelling controversy over Facebooks content algorithms and hate speech. He just cant easily see what its next big opportunity is.

These big technology companies have likely become too important for regulators to ignore, and unwelcome changes for them may lie ahead. But to Munster the winners both provide something essential now and will probably keep doing that as needs rapidly evolve.

How people work five years from now is going to look very similar to the way we worked during the pandemic, Munster said, and employers likely will want all the necessary tools in one package to enable that to work. Microsoft, he said, is in a position to do that.

Even now, counting up the services or products from Microsoft I use took more than the fingers of one hand. Theres writing with Microsoft Word on a Microsoft keyboard, retrieving documents stored in the cloud on OneDrive and connecting with colleagues through the video conferencing and messaging service called Teams.

When Monday morning comes and the mouse is clicked to get into OneDrive, it really needs to work.

And it will.

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Stock market rising on the indispensable companies - Minneapolis Star Tribune

Why are so many doubters unable to leave faith? Watch and read. – Patheos

Alisa Childers is a singer, author and podcaster who is clearly extraordinarily intelligent and perceptive.

Yet, she is also a devout Christian who very nearly left the faith altogether due to fundamental rational doubts but ultimately found her way back by re-embracing reconstructing, in regressive Christian parlance the airy, subjective justifications of supernatural faith she originally held dear.

She did this by effectively ignoring all the excellent objective questions against her faith and focusing instead on the sacredness of historical Christianity and the saving qualities of spiritual grace, and other elements of that self-justifying, excuse-offering branch of Christian theology known as apologetics, or scholasticism.

I had never heard of Childers before the other day, but I was fascinated (in disturbing ways) while watching a nearly 52-minute interview with her conducted by host Cameron Bertuzzi of YouTubes Capturing Christianity site, whose tag line is, BTW, Christianity is true.

From there, I watched on Childerswebsite the 5-minute explanatory video My Story about her authentic Christian fundamentalist upbringing, her budding doubt, semi-deconstruction and then final, reconstructive return to faith.

I also watched her disarmingly interesting 54-minute interview with fellow deconstructed/reconstructed apologist Ian Harbor, in which he encapsulated his long journey away from and back to historical Christianity ostensibly the original faith as a necessary mental exercise of just choosing to believe what the Bible says is absolutely true, doubt aside.

From this interview, I chose to read Harbors article in TGC (The Gospel Coalition), an online Christian media site. This is his disappointing (to rationalists) conclusion in the piece:

There are more paths than ever before in todays worldmore options for spiritual enlightenment or curate-your-own-beliefs faith. But no path leads to true happiness and everlasting life except the Jesus alone path (John 14:6), which is narrower than we might like (Matt. 7:13) but more satisfying than we can imagine (Ps. 16:11).

In my journey I discovered, with Peter, thatGods divine power has granted to us all things that pertain to life and godliness, through the knowledge of him who called us to his own glory and excellence(2 Peter 1:3). In Christ, we have everything we need. Why leave the boundaries of faith once for all delivered to the saints (Jude 1:3) in order to find life? Jesus has the words of life.Heislife. Truth. The way.Where else would we go?

Harbor wrote of arrive at his post-doubt final destination, which wasexactly the same place he started out in faith:

Ive walked in both shoes: the shoes of those who deserted (the faith) and the shoes of (Saint) Peter who couldnt leave, no matter how hard it seemed to stay.

He chose the latter.

I keep reading about devout Christians whose theological questions become so grave that they seriously doubt the core tenets of their faith, yet they still find it impossible to ultimately abandon Christianity. Youd think it wouldnt disturb me anymore, as often as it happens, considering many, many ex-Christians have been able to break free of the chains of dogma and supernatural belief. But it does, because its a willful, self-deceiving capitulation to irrationality, trading fantasy for the necessities of fact.

But surveys consistently tell us that, up to now, the majority of Americans view themselves a God-believing Christians. So, we need to try to understand this strange phenomenon of seemingly groundless faith in omnipotent deities that permanently resists verification.

If you want to better understand this clinging-to-faith tendency, I strongly urge you to watch some or all of these videos, and Ian Harbors well-written if dubiously reasoned article, all linked above.

Whats frightening to me is that Childers and Harbor both obviously very intelligent, thoughtful and articulate spokespeople for their faith have chosen to simply ignore objective reality so they dont have to throw out the baby Jesus of their beliefs with the dirty bathwater doubt leaves behind.

Its fundamentally disingenuous, but Im sure it doesnt feel that way to them, because they truly believe.

Videos/YouTube/Alisachilders.com

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Why are so many doubters unable to leave faith? Watch and read. - Patheos