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Post-lockdown camping: ‘It’s a taste of freedom’ – The Guardian

Posted on July 12, 2020 by Danzig

We arrived at our yurt and said hello to our next-door neighbour, who was stretched out on a deckchair. He replied with a grin and one word: Freedom!

It was Saturday 4 July, the first day that campsites were allowed to open in England after lockdown. My partner and I had left our homes for the first time in nearly four months and driven to the Waveney River Centre in Norfolk, a campsite and marina, to find out what the new normal means for campers.

We were greeted by a battalion of beaming staff, all happy to get the summer season going at last. The first of many hand-sanitiser points was outside reception, which had a one-in, one-out policy and social-distancing markers. Other than that, check-in proceeded as normal. We were staying in one of seven yurts, all fully booked for the weekend, as were the 14 caravan pitches and six camping pods. Only the 45 tent pitches had deliberately not all been filled, to keep numbers at a manageable level. (There are also 35 self-catering lodges on the site.)

As is the case at many campsites, most of the facilities were open, but with some alterations. In the toilet block, alternating cubicles and sinks were taped up so people couldnt get too close. Staff were stationed at the showers all day, ready to clean them after each use. The main shop was closed, but basic items had been moved to the ice-cream kiosk. The play area was open, but the indoor pool was sadly shut, as per (baffling) government guidance.

Liam Holmes, Waveneys general manager, said early feedback from guests had been positive, with people feeling particularly reassured by the visible extra cleaning.

We were greeted by a battalion of beaming staff, all happy to get the summer season going at last

The campsite borders the River Waveney, and we were the first passengers on the newly reopened foot ferry. The service, which dates from the 19th century and was revived in 2012, originally carried south Norfolk villagers to Lowestoft fish market. These days, it takes visitors to Carlton Marshes nature reserve, just across the Suffolk border. We wandered around the marshes, meadows and pools, and spotted birds including a little egret and a marsh harrier. The wide-open space was a balm after so many weeks spent in my tiny London garden.

Back at the campsite, we exercised another regained right and went to the pub. The Waveney Inn had a one-way system with separate entrance and exit, and we had to give our details for contact-tracing purposes. It was table-service only, with contactless payment for our Southwold bitter, fish and chips and ploughmans salad. No one seem deterred by the new measures: the pub was full of families enjoying themselves.

A cold wind had whipped up by bedtime, which gave us a good excuse to light the woodburner in our yurt. The yurt smelled freshly sanitised (the particular antiviral spray used is specified on the website) and was comfortable, with double bed, sofa and electric lamps; guests bring their own bedding.

The next day, we hired a day cruiser from the on-site marina to explored this section of the Broads. Several campers were doing the same there was a queue for the boats. Again, social-distancing measures were in place, with customers fitting their own lifejackets and staff issuing instructions from the bank, rather than boarding boats.

We went as far as Reedham, a riverside village about two-and-a-half hours away, for a pint at the Ship Inn, then stopped halfway back at the Bell Inn at St Olaves for lunch (a generous seafood platter). Staff at both pubs were cheerful and welcoming, and the manager of the Bell Broadlands oldest recorded inn thanked us for supporting them. After months of nothing more exciting than a daily walk, a days boating on the Broads seemed like a real adventure.

Back at the marina, we handed the cruiser keys back and walked a few minutes up the lane to St Marys church, which has a thatched roof and a ziggurat-style tower. More substantial walks include one to Oulton Broad, via the foot ferry, and on to the sandy beach at Lowestoft. More beaches are a short drive away at Great Yarmouth and Southwold.

We ended the day with a barbecue on the deck outside our yurt. By the time we were ready for bed, a low moon was hanging over the river and the sky was full of stars. Our neighbour was right this was a taste of freedom, and it felt fantastic.

Accommodation at Waveney River Centre was provided by Campsites.co.uk, camping from 11 a night, yurts from 48 a night

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Post-lockdown camping: 'It's a taste of freedom' - The Guardian

With Artemis mission, NASA aims to put first woman on the moon soon – The Indian Express

Posted on July 12, 2020 by Danzig

By: Tech Desk | Updated: July 6, 2020 1:12:49 pm Artemis will help scientists explore the South Pole of the moon (Image source: NASA File)

National Aeronautics and Space Administration (NASA) aims to put the first woman on the Moon or next man by 2024. The mission is under NASAs Artemis program which will help in exploring Moons surface as much as possible and create sustainable missions to the Moon by 2028. The research attained from the Moon will work as a building block to explore Mars in the future.

The program is an attempt to put human presence on the moon and revive the American space program. The Artemis mission is named after the twin sister (goddess of the Moon) of Apollo, the mission that put Neil Armstrong on the moon.

During the program, scientists will use the Moons surface as an engineering field of study and practice living in space before taking one step closer to Mars. A few of the main findings of the research will be how the human body reacts to the long durations of spaceflight, creating habitat and living on surfaces foreign to us.

The Artemis program will be carried out in two parts. First, Artemis I will be launched without a crew. This will be done to test the Space Rocket and Orion spacecraft together. Artemis II will be a test flight with a crew ahead of the final launch Artemis III which will put the first woman or the next man on the Moon by 2024.

Another mission of the space program is to understand the water history on the moon. For that, scientists aim to explore the South Pole of the moon.

Earlier, NASA called out the inventors all over the world to develop a toilet that can work on future lunar lander spacecraft and not just in microgravity. The winner of the best-designed toilet for moon will receive a whopping 20,000 dollars.

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From floating guts to ‘sticky’ blood here’s how to do surgery in space – The Conversation UK

Posted on July 12, 2020 by Danzig

Earlier this year, it was reported that an astronaut in space had developed a potentially life-threatening blood clot in the neck. This was successfully treated with medication by doctors on Earth, avoiding surgery. But given that space agencies and private spaceflight companies have committed to landing humans on Mars in the coming decades, we may not be so lucky next time.

Surgical emergencies are in fact one of the main challenges when it comes to human space travel. But over the last few years, space medicine researchers have come up with a number of ideas that could help, from surgical robots to 3D printers.

Mars is a whopping 54.6 million kilometres (33.9 million miles) away from Earth, when closest. In comparison, the International Space Agency (ISS) orbits just 400 kilometres above Earth. For surgical emergencies on the ISS, the procedure is to stabilise the patient and transport them back to Earth, aided by telecommunication in real time. This wont work on Mars missions, where evacuation would take months or years, and there may be a latency in communications of over twenty minutes.

As well as distance, the extreme environment faced during transit to and on Mars includes microgravity, high radiation levels and an enclosed pressurised cabin or suit. This is tough on astronauts bodies and takes time getting used to.

We already know that space travel changes astronauts cells, blood pressure regulation and heart performance. It also affects the bodys fluid distribution and weakens its bones and muscles. Space travellers may also more easily develop infections. So in terms of fitness for surgery, an injured or unwell astronaut will be already at a physiological disadvantage.

But how likely is it that an astronaut will actually need surgery? For a crew of seven people, researchers estimate that there will be an average of one surgical emergency every 2.4 years during a Mars mission. The main causes include injury, appendicitis, gallbladder inflammation or cancer. Astronauts are screened extensively when they are selected, but surgical emergencies can occur in healthy people and may be exacerbated in the extreme environment of space.

Surgery in microgravity is possible and has already been been carried out, albeit not on humans yet. For example, astronauts have managed to repair rat tails and perform laparoscopy a minimally invasive surgical procedure used to examine and repair the organs inside the abdomen on animals, while in microgravity.

These surgeries have led to new innovations and improvements such as magnetising surgical tools so they stick to the table, and restraining the surgeonaut too.

One problem was that, during open surgery, the intestines would float around, obscuring view of the surgical field. To deal with this, space travellers should opt for minimally invasive surgical techniques, such as keyhole surgery, ideally occurring within patients internal cavities through small incisions using a camera and instruments.

A laparoscopy was recently carried out on fake abdomens during a parabolic zero gravity flight, with surgeons successfully stemming traumatic bleeding. But they warned that it would be psychologically hard to carry out such a procedure on a crew mate.

Bodily fluids will also behave differently in space and on Mars. The blood in our veins may stick to instruments because of surface tension. Floating droplets may also form streams that could restrict the surgeons view, which is not ideal. The circulating air of an enclosed cabin may also be an infection risk. Surgical bubbles and blood-repelling surgical tools could be the solution.

Researchers have already developed and tested various surgical enclosures in microgravity environments. For example, NASA evaluated a closed system comprising a surgical clear plastic overhead canopy with arm ports, aiming to prevent contamination.

When orbiting or settled on Mars, however, we would ideally need a hypothetical traumapod, with radiation shielding, surgical robots, advanced life support and restraints. This would be a dedicated module with filtered air supply and a computer to aid in diagnosis and treatment.

The surgeries carried out in space so far have revealed that a large amount of support equipment is essential. This is a luxury the crew may not have on a virgin voyage to Mars. You cannot take much equipment on a rocket. It has therefore been suggested that a 3D printer could use materials from Mars itself to develop surgical tools.

Tools that have been 3D printed have been successfully tested by crew with no prior surgical experience, performing a task similar to surgery simply by cutting and suturing materials (rather than a body). There was no substantial difference in time to completion with 3D printed instruments such as towel clamps, scalpel handles and toothed forceps.

Robotic surgery is another option that has been used routinely on Earth, and tested for planetary excursions. During NEEMO 7, a series of missions in the underwater habitat Aquarius in Florida Keys by NASA, surgery by a robot controlled from another lab was successfully used to remove a fake gallbladder and kidney stone from a fake body. However, the lag in communications in space will make remote control a problem. Ideally, surgical robots would need to be autonomous.

There is a wealth of research and preparation for the possible event of a surgical emergency during a Mars mission, but there are many unknowns, especially when it comes to diagnostics and anaesthesia. Ultimately, prevention is better than surgery. So selecting healthy crew and developing the engineering solutions needed to protect them will be crucial.

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From floating guts to 'sticky' blood here's how to do surgery in space - The Conversation UK

What is network security in the cloud computing era? – TechRadar

Posted on July 12, 2020 by Danzig

Cloud computing has most certainly been an important driver for the next generation of the internet. This key technology has facilitated both online cloud storage and even more recently online services, enabling Software as a Service (SaaS) applications available by subscription.

While cloud computing has been a great enabler for these services, it also has presented new challenges in keeping a network secure. Long gone are the days when a companys IT department could set up computers, and then control the entire flow of traffic - both inbound and outbound alike - via its arranged network with strategically placed firewalls, hubs and antivirus software protecting the clients.

Rather, with cloud computing, there are virtual resources provided over the internet, including data, applications and infrastructure. This then has the potential for sensitive data to be exposed as it gets transmitted from the client to the cloud server and back.

A common vulnerability for cloud computing is known as session hijacking. In this type of attack, the hacker exploits a valid computer session, to then get access to the resources of the cloud server provider.

Here, the cookie that the client is using for authentication for the valid session gets stolen and hijacked. In one variation of the attack, the hacker intercepts the traffic between the client and the server with a Sniffing program, that can grab the cookie (and whatever other data) in what is dubbed a Man-in-the-middle attack'.

Several strategies have been developed to ensure security between clients and the cloud server. They need to be tailored to the specific type of cloud security platform that is vulnerable.

The base for cloud architecture is known as Infrastructure as a Service (IaaS). To protect IaaS, there needs to be network segmentation, and monitoring of the network should include Intrusion Detection Systems (IDS), and Intrusion Prevention Systems (IPS). There should also be virtual web application firewalls that get located in front of the website for malware protection. Virtual routers, and virtual network-based firewalls along the edge of the cloud network provide perimeter protection.

The next cloud solution is Platform as a Service or PaaS. In this architecture the service provider provides the platform to the client which allows them to build applications, while the host company, ie: the cloud provider, builds and services the infrastructure. Security for this type of cloud service can be provided via IP restrictions, and logging. In addition, there should be API Gateways deployed, and a Cloud Access Security Broker (CASB) which controls the policies.

With a SaaS, both the software, and the data are hosted in the cloud, with the service available to each user via a browser. The security for such a configuration is often provided via the Cloud Service Provider (CSP), which is typically negotiated into the service contract. Additionally, a SaaS will incorporate the same suite of security measures as in a PaaS.

A final security measure to implement is a cloudVPN, also known as a VPN as a Service, or aptly designated as a VPNaaS. This cloudVPN is designed to give users the ability to access the cloud servers applications through a browser securely by encrypting the communications.

Compare the 4 best overall VPNs for business and consumers spec-by-spec:

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Balance of options and ease of use

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What is network security in the cloud computing era? - TechRadar

Healthcare Cloud Computing Market (COVID 19 Updated) will register significant gains over the projected time period to 2025 | MicroSoft, Dell, IBM,…

Posted on July 12, 2020 by Danzig

Healthcare Cloud Computing Market report delivers a comprehensive qualitative and quantitative research of the market. According to the current market state, this report continuously observing the promising growth of the global market. The study includes growth trends, micro- and macro-economic indicators in detail with the help of PESTEL analysis. Reports Intellect projects Healthcare Cloud Computing Market-based on elite players, present, past, and futuristic data which will offer as a profitable guide for all the market competitors. Well explained SWOT analysis, revenue share, and contact information are shared in this report analysis. Report Intellect Report aims to provide an evaluation and deliver essential information on the competitive landscape to meet the unique requirements of the enterprises and individuals operating in the Healthcare Cloud Computing Market for the forecast period, 20202026.

Top Companies are covering This Report:-MicroSoft, Dell, IBM, Amazon Web Services, GE healthcare, Oracle, Agfa-Gevaert, Carestream Health, Google Cloud Platform, Alibaba Cloud, Athenahealth

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Our analysts are working ceaselessly to congregate, identify, analyze, and portray the actual impact of Covid-19 on each of our published research reports. Our team analysts have used advanced primary and secondary research techniques and tools to compile this report using top-down and bottom-up approaches and further analyzed using analytical tools. The report offers effective measures and benchmarks for players to secure a position of strength in the market. New players can also use this research study to create business strategies and get informed about future exchange challenges. We provide comprehensive competitive scrutiny that includes detailed company profiling of leading players, a study on the nature and characteristics of the vendor landscape, and other important facts.

Type Coverage:

Software as a Service (SaaS)Platform as a Service (PaaS)Infrastructure as a Service (IaaS)

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HospitalClinicsOthers

Market Segment by Regions, regional analysis covers

North America (United States, Canada, Mexico)

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Healthcare Cloud Computing Market (COVID 19 Updated) will register significant gains over the projected time period to 2025 | MicroSoft, Dell, IBM,...

YellowDog’s Groundbreaking Index Cuts Through the Costs of Cloud Computing – Yahoo Finance

Posted on July 12, 2020 by Danzig

The YellowDog Index dramatically simplifies the analysis of the cost, performance, availability and carbon impact of cloud computing.

BRISTOL, England, July 8, 2020 /PRNewswire/ -- YellowDog, a leading provider of multi-cloud workload management software, has launched an Index that dramatically simplifies cost and performance analysis of cloud computing technology.

The YellowDog Index is the definitive guide to the ever-changing cloud landscape.

The number of cloud instance types available today already stands at over 25,000 variants and is increasing by hundreds each month. The YellowDog Index cuts through the complexity, providing a clear, orderly view of all the worldwide instances in terms of cost, performance, availability and carbon impact. For the first time ever, cloud customers are able to instantly find the best source of compute that precisely matches their needs.

The Index uses the latest information available from sources such as Greenpeace and the US Energy Information Administration.

"Our software enables any business to find the best source of computing power, which may be where it's the cheapest, it has the lowest carbon impact or the highest performance at that moment in time," said Gareth Williams, CEO of YellowDog. "We've created a freely available Index so any business can evaluate and then choose the optimal cloud compute offerings, anywhere in the world.

"Being able to assess the amount of renewable energy used for each cloud, alongside its cost effectiveness and computing power, is becoming increasingly important," he added.

YellowDog already works with cloud partners including Amazon Web Services, Microsoft Azure, Google Cloud Platform, Oracle Cloud Infrastructure, and Verne Global.

"In my time at Microsoft, we saw and helped enable the exponential expansion of compute resource across the globe, and I see strong potential for the YellowDog Platform across enterprises in many verticals," said Reid Downey, a former General Manager for Microsoft and a Non-Executive Director on the Board of YellowDog.

"Cloud computing enables rapid innovation, and YellowDog is a great example of an organization that is using it to revolutionize its industry," said Deepak Patil, former Vice President of Product Development at Oracle.

The YellowDog Index is available at yellowdog.co/yellowdog-index.

About YellowDog

YellowDog, founded in 2015 in Bristol, UK, delivers the Best Source of Compute for hybrid- and multi-cloud workloads. The YellowDog Platform is an intelligent, predictive scheduling and orchestration solution used all over the world for multiple applications.

Photo - https://media.zenfs.com/en/prnewswire.com/35b43d3b68c2b81e1ce20dd3003c065d

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YellowDog's Groundbreaking Index Cuts Through the Costs of Cloud Computing - Yahoo Finance

Cloud Computing is the Focus of this New ETF from Dan Ives and Wedbush – The Wall Street Transcript

Posted on July 12, 2020 by Danzig

July 5, 2020

Dan Ives is Managing Director and Equity Analyst, Technology Sector at Wedbush Securities. Mr. Ives is a world-renowned software and technology analyst with 20-plus years experience educating on cloud computing, cybersecurity, Big Data and the mobile landscape.

Before his tenure at Wedbush Securities, he spent the first few years of his career as a financial analyst at HBO before becoming a well-known research analyst and Managing Director with FBR Capital Markets, focusing on the enterprise software/hardware sectors.

He also served in executive roles at Synchronoss Technologies, a mobile cloud vendor, and GBH Insights, a leading market research firm. Mr. Ives is a highly sought-after tech expert and regularly makes television appearances on networks such as CNBC, Bloomberg, BBC, CNN and Fox to provide commentary related to his technology experience and is often cited by publications such as The Wall Street Journal, USA Today, Investors Business Daily, The Mercury News, Financial Times and The New York Times.

In this 2,828 word interview, exclusively in the Wall Street Transcript, Mr. Ives discusses the sector economics of cloud computing along with an introduction to his new cloud computing ETF.

When you think about call centers, as a good example, more and more of them are moving into the cloud. As they do, companies likeNICE Systems(NASDAQ:NICE) facilitate this move.NICEis one of the bigger holdings in the ETF.

Then, there are application players. You look at companies likeDatadog(NASDAQ:DDOG) andAnaplan(NYSE:PLAN), and these are enablers or facilitators of the next generation of cloud.

These are all examples of companies that are in the IVES ETF, as opposed to applications such as aSlack(NYSE:WORK) andZoom (NASDAQ:ZM) that sit on top of the infrastructure.

The ETF will create returns in this specific sector and will include several stock names that are fairly unknown to investors:

Cloud has many opportunities, but there are also security issues. Thats where cybersecurity names are so important in terms of guarding cloud workloads with the connections, the data and the pipes accelerating to the cloud. These companies are benefiting from the cloud theme.

Cybersecurity names are seeing significant growth related to the cloud shift. We see that with companies likeZscaler(NASDAQ:ZS) orPalo Alto(NYSE:PANW),CyberArk(NASDAQ:CYBR), just to name a few.

There are also international names included in the ETF:

We have companies that are higher, but 4.5% tends to be a lot of the weighted ones. Sinch AB (STO:SINCH) is an Asian infrastructure play and one that plays into the data center theme, especially in Asia.

Get the complete 2,828 word interview for the full detail from Dan Ives, exclusively in the Wall Street Transcript.

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Cloud Computing is the Focus of this New ETF from Dan Ives and Wedbush - The Wall Street Transcript

COVID threats global CLOUD COMPUTING IN K-12 market: Industry outlook, forecast to 2026, key players, segments, regional analysis – Cole of Duty

Posted on July 12, 2020 by Danzig

Global CLOUD COMPUTING IN K-12 Market Research Report gives knowledgeable information on various market situations, for example, potential development factors, factors controlling the development, market opportunities and hazards to the worldwide market.

The report broadly centres around the competitive analysis of CLOUD COMPUTING IN K-12 Market. The competitive analysis segment incorporates key manufacturers, fresh players, providers, market strategies, potential chances, operation landscape and analysis of the trends of the CLOUD COMPUTING IN K-12 Industry. The market results are centred around the current market scenario. To gauge and predict the degree of competition in this market. This report will likewise support all the manufacturers and speculators to have a superior comprehension of the investments to know where the market is heading.

Industry Analysis by Key Players: SAP, Adobe Systems, NetApp, Instructure, Microsoft, Cisco, Blackboard, Salesforce, Ellucian, Dell EMC, Oracle,, etc.

Market Analysis by Type: SaaS, IaaS, PaaS,, etc.

Market Analysis by Applications: Training & Consulting, Integration & Migration, Support & Maintenance,,, etc.

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Report on Global CLOUD COMPUTING IN K-12 Market 2019 comprises of 10 Sections in Table as follows:

The CLOUD COMPUTING IN K-12-market report reads pin-direct analysis for changing serious dynamics with deference towards changing elements that drives or limits market development. It is visualized to comprehend the market point of view and opportunities where it has an extension to develop in future. Basically, the report segregates the ability of the market in the present and the future possibilities from various edges in detail.

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Table of Contents

Global CLOUD COMPUTING IN K-12 Market by Manufacturers, Regions, Type and Application, Forecast to 20261 Report Overview1.1 Definition and Specification1.2 Report Overview1.2.1 Manufacturers Overview1.2.2 Regions Overview1.2.3 Type Overview1.2.4 Application Overview1.3 Industrial Chain1.3.1 CLOUD COMPUTING IN K-12 Overall Industrial Chain1.3.2 Upstream1.3.3 Downstream1.4 Industry Situation1.4.1 Industrial Policy1.4.2 Product Preference1.4.3 Economic/Political Environment1.5 SWOT Analysis2 Market Assessment by Type2.1 SaaS Sales (K Units), Revenue (M USD) and Growth Rate 2014-20202.2 IaaS Sales (K Units), Revenue (M USD) and Growth Rate 2014-20202.3 PaaS Sales (K Units), Revenue (M USD) and Growth Rate 2014-20203 Asia Pacific CLOUD COMPUTING IN K-12 Market Assessment by Type3.1 Asia Pacific Market Performance (Sales, Revenue)3.2 Key Players in Asia Pacific4 North America CLOUD COMPUTING IN K-12 Market Assessment by Type4.1 North America Market Performance (Sales, Revenue)4.2 Key Players in North America5 Europe CLOUD COMPUTING IN K-12 Market Assessment by Type4.1 Europe Market Performance (Sales, Revenue)4.2 Key Players in Europe6 South America CLOUD COMPUTING IN K-12 Market Assessment by Type4.1 South America Market Performance (Sales, Revenue)4.2 Key Players in South America7 Middle Easr and Africa CLOUD COMPUTING IN K-12 Market Assessment by Type4.1 Middle Easr and Africa Market Performance (Sales, Revenue)4.2 Key Players in Middle Easr and Africa8 World CLOUD COMPUTING IN K-12 Market Assessment by Type8.1 Asia Pacific CLOUD COMPUTING IN K-12 Market Assessment by Application (Consumption and Market Share)8.2 North America CLOUD COMPUTING IN K-12 Market Assessment by Application (Consumption and Market Share)8.3 Europe CLOUD COMPUTING IN K-12 Market Assessment by Application (Consumption and Market Share)8.4 South America CLOUD COMPUTING IN K-12 Market Assessment by Application (Consumption and Market Share)8.5 Middle East and Africa CLOUD COMPUTING IN K-12 Market Assessment by Application (Consumption and Market Share)

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COVID threats global CLOUD COMPUTING IN K-12 market: Industry outlook, forecast to 2026, key players, segments, regional analysis - Cole of Duty

Cloud Computing Market Key Insights Based on Product Type, End-use and Regional Demand Till 2025 – Jewish Life News

Posted on July 12, 2020 by Danzig

GlobalCloud Computing industryvalued approximately USD 209.9 billion in 2016 is anticipated to grow with a healthy growth rate of more than 17.93% over the forecast period 2017-2025. The major driver for this industry is the cost-effectiveness. This service of cloud computing helps a various organization to save up to one-third of their annual operations costs. Also, the rising number of SMEs will bolster the use of cloud services.

The objective of the study is to define market sizes of different segments & countries in previous years and to forecast the values to the next eight years. The report is designed to incorporate both qualitative and quantitative aspects of the industry with respect to each of the regions and countries involved in the study. Furthermore, the report also caters the detailed information about the crucial aspects such as drivers & restraining factors which will define the future growth of the market. Additionally, it will also incorporate the opportunities available in micro markets for stakeholders to invest, detailed analysis of competitive landscape and product offerings of key players.

Request To Download Sample of This Strategic Report:https://www.kennethresearch.com/sample-request-10013009

The detailed segments and sub-segment of the market are explained below:

Service:*Infrastructure as a Service (IaaS)*Platform as a Service (PaaS)*Software as a Service (SaaS)

Deployment Model:*Public Cloud*Private Cloud*Hybrid Cloud

Organization Size:*Small & Medium Size Enterprises (SMEs)*Large Enterprises

End-User:*Telecommunications & IT (ICT)*Healthcare*Retail*Public Sector*Media & Entertainment*Banking, Financial Services and Insurance (BFSI)

Regions:*North Americao U.S.o Canada*Europeo UKo Germany*Asia Pacifico Chinao Indiao Japan*Latin Americao Brazilo Mexico*Rest of the World

Furthermore, the years considered for the study are as follows:

Historical year 2015Base year 2016Forecast period 2017 to 2025

Some of the key manufacturers involved in the market are Google Inc., Yahoo Inc., CISCO Systems, Hewlett Packard, IBM Co., Dell Inc., Akamai Technologies, and VM Ware. Acquisitions and effective mergers are some of the strategies adopted by the key manufacturers. Other strategies include new product developments and focus on continuous technology innovation.

Target Audience of the Cloud Computing Market Study

*Key Consulting Companies & Advisors*Large, medium-sized, and small enterprises*Venture capitalists*Value-Added Resellers (VARs)*Third-party knowledge providers*Investment bankers*Investors

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Kenneth Research is a reselling agency providing market research solutions in different verticals such as Automotive and Transportation, Chemicals and Materials, Healthcare, Food & Beverage and Consumer Packaged Goods, Semiconductors, Electronics & ICT, Packaging, and Others. Our portfolio includes set of market research insights such as market sizing and market forecasting, market share analysis and key positioning of the players (manufacturers, deals and distributors, etc), understanding the competitive landscape and their business at a ground level and many more. Our research experts deliver the offerings efficiently and effectively within a stipulated time. The market study provided by Kenneth Research helps the Industry veterans/investors to think and to act wisely in their overall strategy formulation

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AWS Looks to the Final Frontier of Cloud Computing: Space – WebProNews

Posted on July 12, 2020 by Danzig

Amazon Web Services (AWS) has announced a new space business segment aimed at taking cloud computing farther than ever.

Space-based business ventures are coming into their own and getting off the ground (pun intended), with space-based internet, communications, cloud services and more. Manned space trips are increasing in frequency and importance, as countries are looking to the moon and Mars for possible colonization.

AWS sees an opportunity to leverage their extensive cloud experience and portfolio to provide the backbone for these companies and industries. The new business unit, Aerospace and Satellite Solutions, will be run by retired Air Force Major Gen. Clint Crosier, who previously served as the director of Space Force Planning, referring to the latest branch of the US military.

We find ourselves in the most exciting time in space since the Apollo missions, Crosier said in todays announcement from Amazon. I have watched AWS transform the IT industry over the last 10 years and be instrumental in so many space milestones. I am honored to join AWS to continue to transform the industry and propel the space enterprise forward.

Amazons investment in this space (pun intended again) illustrates the importance of the space industry to the US economy and technological future.

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AWS Looks to the Final Frontier of Cloud Computing: Space - WebProNews

Southeast Asia Cloud Computing Market Share 2020 Market Size, Growth rate, Top Manufacturers, Type and Applications, Market Share by Regions, Trends,…

Posted on July 12, 2020 by Danzig

The study on the Southeast Asia Cloud Computing Market by Adroit Market Research is a compilation of systematic details in terms of market valuation, market size, revenue estimation, and geographical spectrum of the business vertical. The study also offers a precise analysis of the key challenges and growth prospects awaiting key players of the Southeast Asia Cloud Computing Market, including a concise summary of their corporate strategies and competitive setting.

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The detailed market intelligence report on the Global Southeast Asia Cloud Computing Market applies the most effective of each primary and secondary analysis to weighs upon the competitive landscape and also the outstanding market players expected to dominate Global Southeast Asia Cloud Computing Market place for the forecast 2019- 2025.

Global market report helps to identify opportunities in market place.

Global market report covers extensive analysis of emerging trends and competitive landscape.

Company Profiles include

Amazon, Akamai Technologies, CA Technologies, Alibaba, Cisco Systems and Google Inc.

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Scope of the Report:

Report evaluates the growth rate and the Market value based on Market dynamics, growth inducing factors. The complete knowledge is based on latest industry news, opportunities and trends. The report contains a comprehensive Market analysis and vendor landscape in addition to a SWOT analysis of the key vendors.

Geographically, this report split global into several key Regions, revenue (Million USD) The geography (North America, Europe, Asia-Pacific, Latin America and Middle East & Africa) focusing on key countries in each region. It also covers market drivers, restraints, opportunities, challenges, and key issues in Global Southeast Asia Cloud Computing Market.

Global market report covers in-depth historical and forecast analysis.

Global market research report provides detail information about Market Introduction, Market Summary, Global market Revenue (Revenue USD), Market Drivers, Market Restraints, Market Opportunities, Competitive Analysis, Regional and Country Level.

Southeast Asia Cloud Computing Market Segmentation:

Segmentation by Type:

by Deployment (Public Cloud, Private Cloud, Hybrid Cloud) by Product (IaaS, PaaS, SaaS) by Organization (Small, Medium, Large) by Application (IT & Telecom, BFSI, Aerospace & Defense, Healthcare, Manufacturing, Government & Utilities, Retail, Consumer Electronics, Others)

Segmentation by Application:

by Application (IT & Telecom, BFSI, Aerospace & Defense, Healthcare, Manufacturing, Government & Utilities, Retail, Consumer Electronics, Others)

This comprehensive report will provide:* Enhance your strategic decision making* Assist with your research, presentations and business plans* Show which emerging market opportunities to focus on* Increase your industry knowledge* Keep you up-to-date with crucial market developments* Allow you to develop informed growth strategies* Build your technical insight* Illustrate trends to exploit* Strengthen your analysis of competitors* Provide risk analysis, helping you avoid the pitfalls other companies could make* Ultimately, help you to maximize profitability for your company.

Our Market Research Solution Provides You Answer to Below Mentioned Question:1. Which are the driving factors responsible for the growth of market?2. Which are the roadblock factors of this market?3. What are the new opportunities, by which market will grow in coming years?4. What are the trends of this market?5. Which are main factors responsible for new product launch?6. How big is the global & regional market in terms of revenue, sales and production?7. How far will the market grow in forecast period in terms of revenue, sales and production?8. Which region is dominating the global market and what are the market shares of each region in the overall market in 2017?9. How will each segment grow over the forecast period and how much revenue will these segment account for in 2025?10. Which region has more opportunities?

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Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable market insights to help create opportunities that increase their revenues. We follow a code Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Southeast Asia Cloud Computing Market Share 2020 Market Size, Growth rate, Top Manufacturers, Type and Applications, Market Share by Regions, Trends,...

Tech Run Not Done And That’s a Plus for This Dynamic ETF – ETF Trends

Posted on July 12, 2020 by Danzig

Once again, technology is one of the best-performing sectors this year and the diverse ALPS Disruptive Technologies ETF (CBOE: DTEC) is participating in that trend.

Up more than 30% over the past 90 days, DTEC is benefiting from increasing adoption of cloud computing, cybersecurity, and Internet of Things (IoT) technologies, among other catalysts.

Cloud computing is rapidly growing, was doing so prior to the pandemic, and will continue doing so after the virus is quashed. Declining costs in cloud adoption and increasing ease of use are among the factors driving the cloud computing boom. Several DTEC components have first-mover advantages in various cloud niches and are building attractive competitive moats in the space. CLOUs IaaS exposure should beneficial to long-term investors.

The increasingly digital and connected exhibiting significant growth and is expected to continue to grow over the coming years. The cloud computing industry that was estimated to be worth$188 billionin 2018 is expected to be worth over$300 billionby 2022, a nearly 15% annualized growth rate. IaaS is a major contributor to that growth.

The widespread shift to working and learning from home, and the shutdown of many bricks-and-mortar retail stores, has accelerated the adoption of both cloud-based computing and online shopping, to the benefit of many companies, reports Eric Savitz for Barrons.

DTEC tracks the Indxx Disruptive Technologies Index, which identifies companies using disruptive technologies across ten thematic areas, including Healthcare Innovation, Internet of Things, Clean Energy and Smart Grid, Cloud Computing, Data and Analytics, FinTech, Robotics, and Artificial Intelligence, Cybersecurity, 3D Printing, and Mobile Payments.

With second-quarter earnings season looming, expectations are in place that those reports will be ugly due to the coronavirus. However, the tech sectors earnings and revenue retrenchment is forecast to be mild. In fact, only utilities revenue and profit contraction will be less bad than tech, according to Refintiv data.

Some analysts arent backing away from the sector. Rather, some see more upside ahead for already stout tech names across an array of segments.

We believe tech stocks could still go another 20%-30% higher, writes Wedbush analyst Dan Ives. While fears of a second wave and a soft macro will cause volatility over the coming months, especially with earnings season around the corner, we remain firmly bullish on tech for the rest of the year with cloud and cybersecurity names front and center.

Other technology funds to consider include the Technology Select Sector SPDR ETF (NYSEArca: XLK) and the Fidelity MSCI Information Technology Index ETF (FTEC).

For more on cornerstone strategies, visit our ETF Building Blocks Channel.

The opinions and forecasts expressed herein are solely those of Tom Lydon, and may not actually come to pass. Information on this site should not be used or construed as an offer to sell, a solicitation of an offer to buy, or a recommendation for any product.

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Tech Run Not Done And That's a Plus for This Dynamic ETF - ETF Trends

Enhance your cloud threat protection with 5 tools, and more – TechTarget

Posted on July 12, 2020 by Danzig

In 2019, more enterprise workloads were executed in the cloud than on premises for the first time.

To be precise: 56% of workloads were executed in the cloud -- either as IaaS, PaaS or SaaS -- compared to 44% on premises (of that, 40% were in the data center and 4% in branch offices).

This tells us that organizations must get serious about cloud threat protection, and that requires tackling two things: protecting cloud-based resources and using cloud-based services to do so. Doing both requires making organizational, operational and funding changes -- plus investing in the right technologies.

Let's address these necessary changes in order.

One of the best success metrics for cybersecurity organizations -- and the metric that Nemertes Research, where I work, relies on to measure cybersecurity success -- is mean total time to contain (MTTC) security breaches. MTTC includes the sum of the time required to detect a potential attack, understand that it is in fact an attack and contain it. Nemertes' analysts measure MTTC annually, most recently in our 2019-2020 "Cloud and Cybersecurity Research Study," in which we assessed MTTC for 335 firms in 11 countries, across 24 industry verticals.

The median MTTC across all of the companies Nemertes studied is 180 minutes. We selected the organizations in the 80th percentile and above as our success group. The companies in this group have an MTTC of 20 minutes or fewer.

While it's far from the only relevant metric, MTTC is a good measure of a cybersecurity organization's maturity; cybersecurity organizations with a low MTTC generally have better security practices than those with a higher MTTC.

Practices that correlate with lowering MTTC for cloud-enabled organizations include the following:

So far, so good. But what technologies should be included in that budget and architecture?

The following technologies correlate with a measurable improvement in MTTC and, thus, should be considered by cloud-enabled organizations:

Cloud-based identity and access management (IAM) provides a platform for single-credential and single sign-on authentication across multiple cloud platforms, and possibly internal systems. Vendors that provide IAM as a service include Microsoft, Okta, OneLogin and Ping Identity. Using IAM as a service correlates with 50% improvement in MTTC.

Cloud access security brokers (CASBs) provide additional security controls on and visibility into enterprise use of cloud resources. They can be in-line proxy-style intermediaries through which cloud-bound traffic passes, or they can be API-based services that are called upon by cloud services for authentication and authorization of user access -- and to which cloud services send monitoring event information on use of the service.CASBs are available from Bitglass, Netskope, Microsoft and McAfee. Using CASBs correlates to 50% improvement in MTTC.

Behavioral threat analytics (BTA), sometimes referred to as user and entity behavioral analytics, integrates multiple sources of data -- such as logs, analytics platforms and SIEM -- to capture and display anomalous behavior of users, devices and systems. BTA examples includeBroadcom Bay Dynamics, Gurucul, Exabeam and Splunk. Using BTA correlates to 41.7% improvement in MTTC.

Cloud-based firewalls are virtual entities in the cloud, as opposed to physical devices in physical locations. Most major firewall providers (including Palo Alto, Cisco, Check Point and others) offer cloud-based versions of their services. Most major telcos and cloud security providers -- like Verizon, AT&T, CenturyLink and Masergy Communications -- offer cloud-based firewall services. Using cloud-based firewalls correlates with a 50% improvement in MTTC; 60% of organizations studied by Nemertes had enabled cloud-based firewalls.

Secure Access Service Edge (SASE) tools enable mobile and home users and sites to connect via a secure point of presence to a secured network operator's core network. These tools then apply security policies to control access to resources on premises or in the cloud. SASE products include Cisco Umbrella and Palo Alto Prisma. The use of SASE correlates with a 17% improvement in MTTC.

What does this mean for enterprise security professionals? First, if you don't yet have cloud security specialists, hire them or grow your own via training and certification. This step is essential even if it means increasing headcount in the cybersecurity organization. If you can get there by trimming headcount in other areas, so much the better, but, regardless, having a team in place is the first step toward success.

The era of cloud cybersecurity is dawning.

Second, ensure the cloud security team is well funded. The greatest improvements in MTTC correlate with having line items for this team's budget in both the cloud and cybersecurity budget. Either one is good; both is best.

Third, the cloud security team's first act should be to develop a cloud security architecture and strategy. Which critical technologies listed above do you plan to implement, and how will they be integrated together? This architecture and strategy should include fundamental technology principles that will be used to drive vendor and product selection. It should also generate a roadmap laying out the sequence of procuring and installing the technology.

Fourth, based on that cloud security strategy, architecture and roadmap, the cloud cybersecurity team should begin selecting and implementing the key technologies.

Fifth and finally, teams shouldn't neglect documenting and implementing the cybersecurity operational changes driven by the move to cloud threat protection. For example, cloud security providers need to be fully integrated into an organization's incident response policy.

The bottom line: As workloads move to the cloud, so should the means of protecting them. The era of cloud computing is here. The era of cloud cybersecurity is dawning.

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Enhance your cloud threat protection with 5 tools, and more - TechTarget

Cloud Computing Security Software Market Growth By Manufacturers, Type And Application, Forecast To 2026 – 3rd Watch News

Posted on July 12, 2020 by Danzig

New Jersey, United States,- Market Research Intellect sheds light on the market scope, potential, and performance perspective of the Global Cloud Computing Security Software Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the global Cloud Computing Security Software market.

The research study includes the latest updates about the COVID-19 impact on the Cloud Computing Security Software sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

Leading Cloud Computing Security Software manufacturers/companies operating at both regional and global levels:

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The Cloud Computing Security Software market report provides successfully marked contemplated policy changes, favorable circumstances, industry news, developments, and trends. This information can help readers fortify their market position. It packs various parts of information gathered from secondary sources, including press releases, web, magazines, and journals as numbers, tables, pie-charts, and graphs. The information is verified and validated through primary interviews and questionnaires. The data on growth and trends focuses on new technologies, market capacities, raw materials, CAPEX cycle, and the dynamic structure of the Cloud Computing Security Software market.

This study analyzes the growth of Cloud Computing Security Software based on the present, past and futuristic data and will render complete information about the Cloud Computing Security Software industry to the market-leading industry players that will guide the direction of the Cloud Computing Security Software market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

Sales Forecast:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Cloud Computing Security Software market. Additionally, it includes a share of each segment of the Cloud Computing Security Software market, giving methodical information about types and applications of the market.

Reasons for Buying Cloud Computing Security Software Market Report

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It renders an in-depth analysis for changing competitive dynamics.

It presents a detailed analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by performing a pin-point analysis of market segments and by having complete insights of the Cloud Computing Security Software market.

This report helps the readers understand key product segments and their future.

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In the end, the Cloud Computing Security Software market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the global Cloud Computing Security Software market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Cloud Computing Security Software Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

There is a strong genetic component to asthma, but it’s not the only risk factor – Insider – INSIDER

Posted on July 12, 2020 by Danzig

Asthma is a chronic condition that causes your airways to become inflamed leading them to swell and narrow. This makes it harder for you to breathe and can cause dangerous asthma attacks.

Asthma is often linked to other health conditions like hay fever and environmental factors including air pollution. However, research also shows that carrying certain genes can put you at greater risk of developing asthma.

Here's what you need to know about what causes asthma and how it can be passed down through families.

Scientists have identified more than one hundred specific genes that may play a role in whether or not a person develops asthma. In fact, a person with at least one biological parent with asthma is 3 to 6 times more likely to develop the condition than someone whose parents don't have asthma.

However, even if you are born with asthma-related genes, you may not develop asthma unless those genes are "turned on," likely by something in your environment. "Multiple genes may be involved and they could be triggered by a number of factors, such as viral infections," says Stanley Szefler, MD, the Director of the Pediatric Asthma Research Program at Children's Hospital Colorado.

This means that if you have asthma-related genes and suffer a bad respiratory infection as a child, this could kickstart a lifelong asthma condition. However, experts say that more research is needed to fully understand how these genes interact with the environment to cause asthma in the first place.

Doctors have identified several different types of asthma including adult-onset asthma, allergic asthma, and exercise-induced asthma. Scientists have not linked any specific genes to a particular type of asthma, Szefler says. However, there is evidence that every type of asthma has a genetic component.

In a study, published in 2008 in Twin Research and Human Genetics, researchers compared the incidence of asthma in twins to determine how strongly genes affect the likelihood of developing asthma, compared with environmental factors. The results showed that genetics plays a very large role the genes account for about 70% of your risk of developing asthma.

It's important to remember that even though genes are an important risk factor for asthma:

About half of all asthma sufferers start having symptoms as children age 5 and younger. But for people who develop asthma later in life, genes are less likely to play a role. This may be because some older people develop asthma due to lifestyle choices like smoking.

In addition to genetics, asthma may be caused by:

In many cases, experts don't know why some people develop asthma while others don't. However, there are risk factors that can increase your risk. These include:

There is no way to prevent asthma, even if you start treatment early on after your symptoms develop, says Szefler. Researchers are starting to look at whether using biologic medications containing live bacteria could work to prevent asthma, Szelfer says, "but the results are several years off."

However, even if you can't prevent asthma, there are steps you can take to prevent asthma attacks:

Asthma is an ongoing condition and you should "maintain good medical follow-up to keep the disease under control," Szefler says. You will need to make an individual treatment plan with your doctor, designed to target your symptoms and help avoid your asthma triggers.

There is a strong genetic component to asthma, but it's not the only risk factor - Insider - INSIDER

Four Rivers Wildlife: The color of my skin – Murray Ledger and Times

Posted on July 12, 2020 by Danzig

You mean our skin color is controlled by just a few genes? The question came from the front row. There is simply nothing better for a teacher than seeing the imaginary light bulb go on. In this case, the bulb burned bright, as the science had social implications.

Skin color in humans is controlled by the amount of melanin our cells produce. The more melanin, the darker the skin, and melanin production is controlled by the genes we have inherited from our parents. Although there are multiple genes involved, melanin genetics is relatively simple compared to some other traits. Because each gene has alternative forms, there is a diverse, continuous distribution of possible skin colors. We use labels like black and white but skin color is much more precise than that, because humans are a lot more variable than the categories our minds want to place each other in.

Consider my niece, whose ivory skin is a consequence of her German ancestry. She married a darkly skinned gentleman from India. Because of the multiple genes involved, their sons skin color could have been very white like his mother or very dark like his father, although those options were extremely unlikely. In fact, he is somewhere intermediate in the distribution of possibilities, exactly where you would expect. In contrast, my own skin had little chance of being different than my parents, because both them had very similar skin color.

The genetics that underlie human skin color, eye color, and even whether your earlobes are attached or not follow the same basic mechanisms that we see in other organisms, from microbes to wildlife. All life shares the same general process, although the specific mechanisms producing color patterns vary across species.

For example, gray squirrels come in three color morphs, or forms, and this occurs in part because the genetics of squirrel color is simpler than in humans. Most are gray on top with a white belly, but because of variation at a single gene, some are completely jet-black, and a few are black on top but brown underneath.

In contrast, ladybugs have more than 200 color patterns, although the ones we see in North America are usually reddish with about 20 black spots. In their native Asia, there are many more colors, including all red without spots, and all black with red spots. Like squirrels, this variation is controlled by a single gene, but this gene is turned on or off in specific places by other genes, producing one of the most variable color patterns of any animal.

These examples support one basic idea: the color of many organisms, from ladybugs to humans, is genetically determined. However, humans differ from other animals in how we perceive and react to these colors. Squirrels do not treat each other differently based on color. Most mammals, including squirrels, use smell rather than vision as their primary sense. Similarly, insect behavior is influenced more by chemical cues than vision. In these species, color patterns are used for hiding from predators or regulating temperature, not for determinations of social status.

Our color vision has social implications that we cannot ignore. Perhaps as we consider such questions, and the social changes that we are a part of, we will realize that the heart of the matter is unchanging: we are all one species.

The color of our skin is a genetically-determined trait, like those of squirrels and ladybugs. Our skin color is beyond our control, just like we cannot determine whether our earlobes are attached or not. But our behavior is not. How we perceive and respond to skin color and other traits is what makes us human. And no matter what the color of my skin, or yours, we are all related, whether we are brothers and sisters, nieces and nephews, or very distant cousins.

Humans do not treat each other differently based on earlobes, nor should we do so based on the color of our skin. Its easy to write that, but much harder to do. But understanding that skin color is just one of many traits that are a result of basic genetic principles might turn on imaginary light bulbs throughout the world, brightening all of our lives.

Four Rivers Wildlife: The color of my skin - Murray Ledger and Times

Alzheimer’s disease: protective gene uncovered in human cell model bringing promise for new drug discoveries – The Conversation UK

Posted on July 12, 2020 by Danzig

Every three seconds, someone in the world develops dementia. The most common form of dementia is Alzheimers disease. While researchers have identified a number of risk factors that are linked to dementia including genetics, smoking, and high blood pressure there is currently still no cure.

Part of the reason for this is because of how complicated it is to test potential Alzheimers drugs. In order to conduct clinical trials participants need to have symptoms. But by the time symptoms appear, its usually too late for treatments to have a large effect as many of their brain cells have already died.

But our latest research developed a new human cell model that is able to rapidly simulate the development of Alzheimers disease in the lab. This allowed us to identify a gene, called BACE2, that is naturally able to suppress the signs of Alzheimers disease in human brain cells. Our research is the result of around five years work, and was the collaborative effort of teams based in London, Singapore, Sweden and Croatia.

Researchers already know a lot about which genes cause Alzheimers disease or make someone more likely to develop it. These genes contribute to certain toxic proteins accumulating in the human brain. So our team thought that the opposite must also be true: our brain cells must also have proteins that can naturally slow down the development of Alzheimers.

One gene that can definitely cause Alzheimers disease is a gene found on the 21st pair of human chromosomes that is responsible for making the amyloid precursor protein (APP). Research shows that 100% of people born with just one extra copy of the APP gene (called DupAPP) will develop dementia by age 60.

People with Downs syndrome are born with three copies of APP because they have a third 21st chromosome. But by age 60, only 60% of them will develop clinical dementia. We wanted to know why some people with Downs syndrome have delayed development of or never develop Alzheimers dementia compared to those who have one extra DupAPP gene.

The simple answer for this is because they have an extra dose of all other genes located in chromosome 21. We believed that there could be some dose-sensitive genes on chromosome 21 that, when triplicated, protect against Alzheimers disease by counteracting the effects of the third APP gene.

These genes must then appear to delay the onset of clinical dementia in some people with Downs syndrome by approximately 20 years. Studies have even shown that any future drug able to delay dementia onset by just five years would reduce the prevalence of Alzheimers in the general population by half.

To study the potential of the extra genes, we took hair follicle cells from people with Downs syndrome and re-programmed the cells to become like stem cells. This allowed us to turn them into brain cells in a Petri dish.

We then grew them into 3D balls of cells that imitated the tissue of the grey matter (cortex) of the human brain. The 3D nature of the culturing allowed misfolded and toxic proteins to accumulate, which are crucial changes that lead to Alzheimers disease in the brain.

We found all three major signs of Alzheimers disease (plaque build-up in the brain, misfolded tau proteins and dying brain neurons) in cell cultures from 71% of people with Downs syndrome who donated samples. This proportion was similar to the percentage of clinical dementia among adults with Downs syndrome.

We were also able to use CRISPR a technology that allows researchers to alter DNA sequences and modify a genes function to reduce the number of BACE2 genes from three copies to two copies on chromosome 21. This was only done in cases where there were no indications of Alzheimers disease in our cellular model. Surprisingly, reducing the number of BACE2 genes on chromosome 21 provoked signs of the disease. This strongly suggest that having extra copies of a normal BACE2 gene could prevent Alzheimers.

The protective action of BACE2 reduces the levels of toxic amyloid proteins. This was verified in our cellular models, as well as in cerebrospinal fluid and post-mortem brain tissue from people with Downs syndrome.

Our study provides proof that natural Alzheimers-preventing genes exist, and now we have a system to detect new potential protective genes. Importantly, recent research showed the protective action of BACE2 might also be relevant to people who dont have Downs syndrome.

Our results also show that all three signs of Alzheimers disease can be potentially detected in cells from live donors. Though this requires a lot more research, it means we may be able to develop tests that identify which people are at higher risk of Alzheimers disease by looking at their cells.

This would allow us to detect the disease before it starts developing in a persons brain, and could make it possible to design personalised preventative treatments. However, we are still a long way from reaching this goal.

Most importantly, our work shows that all three signs of Alzheimers disease detected using our model could be prevented by drugs known to inhibit the production of the toxic amyloid protein and this can be detected in as little as six weeks in the lab. We hope our discovery could lead to the development of new drugs aimed at delaying or preventing Alzheimers disease, before it causes brain cell death.

Gaucher Disease Treatment Market 2016 Analysis, Types, Applications, Forecast 2028 – Jewish Life News

Posted on July 12, 2020 by Danzig

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According to the report, thegaucher disease treatment market has been segmented by disease type (type i, type ii, type iii), by treatment type (enzyme replacement therapy (ERT), substrate reduction therapy (SRT)).

Insights about regional distribution of market:

The market has been segmented in major regions to understand the global development and demand patterns of this market.

For gaucher disease treatment market, the segments by region are North America, Asia Pacific, Western Europe, Eastern Europe, Middle East, and Rest of the World. During the forecast period, North America, Asia Pacific and Western Europe are expected to be major regions on the gaucher disease treatment market.

North America and Western Europe have been one of the key regions as they have an established healthcare infrastructure for product innovations and early adaptations. This is estimated to drive demand for gaucher disease treatment market in these regions. In addition to this, some of the major companies operating in this market are headquartered in these regions.

Company profiled in this report based on Business overview, Financial data, Product landscape,Strategic outlook & SWOT analysis:

1. Pfizer Inc.2. Acetelion Pharmaceutical (J&J Ltd.)3. Shire Human Genetics Therapies, Inc.4. Erad Therapeutic Inc.5. JCR Pharmaceuticals Co Ltd.

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Asia Pacific is estimated to register a high CAGR forgaucher disease treatment market. The APAC region has witnessed strategic investments by global companies to cater the growing demand for healthcare solutions in the recent years. Middle East and rest of the World are estimated to be emerging regions for gaucher disease treatment market.

Market Segmentation:By Disease Type:Type IType IIType III

By Treatment Type:Enzyme Replacement Therapy (ERT)Substrate Reduction Therapy (SRT)

By Region:North AmericaNorth America, by CountryUSCanadaMexicoNorth America, by Disease TypeNorth America, by Treatment Type

Western EuropeWestern Europe, by CountryGermanyUKFranceItalySpainThe NetherlandsRest of Western EuropeWestern Europe, by Disease TypeWestern Europe, by Treatment Type

Asia PacificAsia Pacific, by CountryChinaIndiaJapanSouth KoreaAustraliaIndonesiaRest of Asia PacificAsia Pacific, by Disease TypeAsia Pacific, by Treatment Type

Eastern EuropeEastern Europe, by CountryRussiaTurkeyRest of Eastern EuropeEastern Europe, by Disease TypeEastern Europe, by Treatment Type

Middle EastMiddle East, by CountryUAESaudi ArabiaQatarIranRest of Middle EastMiddle East, by Disease TypeMiddle East, by Treatment Type

Rest of the WorldRest of the World, by CountrySouth AmericaAfricaRest of the World, by Disease TypeRest of the World, by Treatment Type

Objectives of this report:o To estimate the market size for gaucher disease treatment market on a regional and global basis.o To identify major segments in gaucher disease treatment market and evaluate their market shares and demand.

o To provide a competitive scenario for the gaucher disease treatment market with major developments observed by key companies in the historic years.o To evaluate key factors governing the dynamics of gaucher disease treatment market with their potential gravity during the forecast period.

Reasons to Buy This Report:o It provides niche insights for a decision about every possible segment helping in the strategic decision-making process.o Market size estimation of the gaucher disease treatment market on a regional and global basis.o A unique research design for market size estimation and forecast.o Identification of major companies operating in the market with related developmentso Exhaustive scope to cover all the possible segments helping every stakeholder in the gaucher disease treatment market.

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Gaucher Disease Treatment Market 2016 Analysis, Types, Applications, Forecast 2028 - Jewish Life News

How Could Human Nature Have Become This Politicized? – The New York Times

Posted on July 12, 2020 by Danzig

The formulation of what has come to be known as moral foundations theory has been crucial to a deeper understanding of this process. The theory

proposes that the human mind is organized in advance of experience so that it is prepared to learn values, norms, and behaviors related to a diverse set of recurrent adaptive social problems.

Leading proponents argue that there are

five foundations of intuitive ethics: care/harm; fairness/cheating; loyalty/betrayal; authority/subversion; and sanctity/degradation.

The theory is described in detail in Moral Foundations Theory: The Pragmatic Validity of Moral Pluralism, a 2013 paper by Jesse Graham of the University of Utah; Jonathan Haidt of N.Y.U.; Sena Koleva, a research consultant; Matt Motyl of the University of Illinois at Chicago; Ravi Iyer, chief data scientist for Ranker, a consumer internet platform; Sean P. Wojcik, a senior data scientist at the news site Axios; and Peter H. Ditto, of the University of California-Irvine.

What makes moral foundations theory especially relevant now is that in recent decades liberal and conservative partisans have divided over the importance they place on these five moral foundations:

Liberals valued Care and Fairness more than did conservatives, whereas conservatives valued Loyalty, Authority and Sanctity more than did liberals.

These differences mattered little for politics when both parties included liberals and conservatives, but beginning around 1964, this disagreement between left and right on moral values began to coincide more strongly with party affiliation.

A number of scholars have put forth ideas in an effort to understand these developments.

Kevin Smith, a political scientist at the University of Nebraska whose research explores the biology and psychology of individual-level differences in political attitudes and behavior, emailed in response to my inquiry:

Fights about abortion, gay rights, gun rights etc. are less about policy than about underlying core values, values that for many are not up for discussion or compromise because they are deeply held indeed, given the genetic influences on such attitudes, its probably fair to say they are at least partly biologically instantiated.

Smith, who is a co-author of Predisposed: Liberals, Conservatives and the Biology of Political Differences, argues that as political parties have coalesced along ideologically consistent lines, especially on issues related to race, they have

created a political environment where genetically influenced predispositions, what most people would experience as gut feelings that one side or the other is right or wrong on a given set of issues of the day, made partisanship something that was much more likely to become a central part of someones identity.

Smith is quite explicit that he does not posit that there is biological determinism of political views or anything else, but he does contend that

theres little doubt that ideological orientations are genetically influenced, and to a surprisingly high degree studies consistently estimate roughly 40-60 percent of the population level variance in ideology is under genetic influence.

The ideological realignment of the parties that has pushed many liberal Republicans into the Democratic camp and conservative Democrats in the opposite direction, Smith writes, has created a political environment in which

those with strong predispositions to lean one way or the other can readily mate those instinctual feelings to a political party that espouses and affirms those predispositions.

At that point, he continues,

Youve got a recipe for deeply polarized politics that is going to feed on its own dynamics and be hard to change. And that sounds awfully like the political environment we have right now.

In Predisposed, Smith and John Hibbing and John Alford, his co-authors, stress that we are not making a nature versus nurture argument.

Instead, they write, innate forces combine with early development and later powerful environmental events to create attitudinal and behavioral tendencies. A predisposition can be altered. Nonetheless,

predispositions nudge us in one direction or another, often without our knowledge, increasing the odds that we will behave in a certain way, but leaving plenty of room for predispositions to be contravened.

Kevin Arceneaux, a political scientist at Temple, stressed in an email that

It is important to resist the tendency to see heritability of eye color, for example, as the same thing as the heritability of an attitude. I cannot change my eye color, but I can change my attitudes.

Some of the most interesting work in the field of behavioral genetics, Arceneaux continues, shows how

context interacts with genetic influences. If you change the context, the heritability of behavioral constructs changes. So, I would caution against drawing a straight line from heritability to unchanging/intractable.

Along the same lines, Yuan Chang Leong, a postdoctoral fellow in the psychology department at Berkeley, emailed me that

What is heritable is unlikely to be ideology per se, but something more akin to personality traits or a predisposition to respond to certain information in a particular way.

The relationship between these factors and policy positions, Leong continued,

are not set in stone. There is evidence that partisans can be persuaded by political messages, especially when the messages are framed in a manner that appeals to them, so efforts at persuasion are not futile.

Ariel Malka, a professor of psychology at Yeshiva University, believes that religiosity, authoritarianism, and conservative cultural attitudes are rooted in personality traits that have some heritable components.

In an email, Malka noted that

Increased partisan polarization in the U.S. has coincided with the parties placing greater (and opposing) emphases on racial and culture war positions. So its certainly plausible that American polarization stems from partisan conflict having expanded into the racial and cultural areas, aligning this heritable attitude syndrome with partisanship.

Malka cited the work of Amanda Friesen and Aleksander Ksiazkiewicz, political scientists at Indiana University-Purdue University Indianapolis and the University of Illinois-Urbana, who are the authors of Do Political Attitudes and Religiosity Share a Genetic Path?

Friesen and Ksiazkiewicz are persuaded that

certain religious, political, and first principle beliefs on social organization can be explained by genetic and unique environmental components, and that the correlation between these three trait structures is primarily due to a common genetic path.

Malka also points to the work of Steven Ludeke, Wendy Johnson and Thomas J. Bouchard Jr., psychologists at the University of Southern Denmark, the University of Edinburgh and the University of Minnesota, whose findings are described in the title of their 2014 paper, Obedience to traditional authority: A heritable factor underlying authoritarianism, conservatism and religiousness.

In Malkas view, the strength of these predispositions to authoritarianism, religiousness and conservatism has been crucial to the success of Republicans in winning support from white middle-class and working-class voters, many of whom hold strongly liberal views on economic policy.

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How Could Human Nature Have Become This Politicized? - The New York Times

30% South Asians have Neanderthal gene that increases risk of severe Covid-19: Study – ThePrint

Posted on July 12, 2020 by Danzig

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New Delhi: A piece of the human gene that increases the risk of severe illness from the coronavirus was inherited from Neanderthals over 60,000 years ago, a new study has suggested.The gene in question is carried by 30 per cent of the South Asian population, but is almost completely absent in African people.

In a paper posted on bioRxiv that is yet to be peer-reviewed, scientists from Max Planck Institute for Evolutionary Anthropology in Germany showed that the string of DNA that puts people at increased risk of severe Covid-19 is the same version found in a Neanderthal who lived in Croatia some 50,000 years ago.

Neanderthals are an extinct species of ancient humans who lived in Eurasia until about 40,000 years ago.

We can currently only speculate why the frequency is so high in South Asia, Hugo Zeberg, a co-author of the study, told ThePrint over email.

Zeberg added that the gene variant may have been favourable for the survival of humans earlier, but at this point, it is not clear why it managed to survive 60,000 years.

Also read: Faulty gene linked to dementia doubles risk of severe Covid infection, finds new study

Chromosomes are thread-like structures located inside the nucleus of cells. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA). The DNA contains the specific instructions or genetic code that makes each individual unique.

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Humans have 23 pairs of chromosomes. People normally have two copies of each chromosome.

In a recent study, researchers found a strong association between severe Covid-19 and two genomic regions: One region on chromosome 3 containing six genes, and one region on chromosome 9 that determines the ABO blood group.

Chromosome 3 spans almost 200 million base pairs or letters, and represents about 6.5 percent of the total DNA in cells. Researchers found that a unique combination of about 50,000 base pairs in chromosome 3 puts people at risk of severe Covid-19.

Then, a study of 3,199 hospitalised patients by the Covid-19 Host Genetics Initiative, a global consortium of scientists working in genetics, confirmed the association between this genetic string and increased risk for severe SARS-CoV-2 infection and hospitalisation.

The Max Planck Institute study followed, establishing the genes link to Neanderthals, and its team further used an online database to determine which populations are more likely to have it.

Also read: Stanford University develops gene-editing tool that can destroy Covid-19 inside human cells

According to some scientists, modern humans migrated out of Africa and interbred with Neanderthals in Eurasia some 200,000 years ago. Then 140,000 years later, Eurasians with Neanderthal ancestry migrated to Africa, interbreeding with the descendants of the humans who never left.

As a result, about 1-4 per cent of genomes of Eurasians, Native Americans, and North Africans derive from Neanderthals.About 20 per cent of the Neanderthals genes continue to survive today in humans.

The team determining the presence of the gene in modern populations found that while it is almost completely absent in Africa, it occurs in South Asia at a frequency of 30 per cent.

The highest frequency occurs in Bangladesh, where more than half the population (63 per cent) carries at least one copy of the Neanderthal risk variant, and 13 per cent have a similar variant of the gene segment.

About eight per cent of Europeans have this variant, while for mixed-race Americans, the variant is present in 4 per cent of the population.

The researchers conclude that the Neanderthal variant may thus be a substantial contributor to Covid-19 risk in certain populations.

One should stress that at this point this is pure speculation, Svante Paabo, another co-author of the Max Planck Institute study, told New York Times.

Also read: Indian scientists find Covid gene in wastewater a breakthrough in tracking virus outbreak

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30% South Asians have Neanderthal gene that increases risk of severe Covid-19: Study - ThePrint

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