Twitter hackers who targeted Elon Musk and others received $121,000 in bitcoin, analysis shows – CNBC

On Wednesday, the Twitter accounts of some of the most famous people in the country were compromised as part of an apparent bitcoin scam.

Victims included Democratic presidential candidate Joe Biden, former President Barack Obama and Tesla CEO Elon Musk. Accounts for those people, and others, posted tweets asking followers to send bitcoin to a specific anonymous address.

For their efforts, the scammers received over 400 payments in bitcoin, with a total value of $121,000 at Thursday's exchange rate, according to an analysis of the Bitcoin blockchainperformed by Elliptic, a cryptocurrency compliance firm.

Elliptic co-founder Tom Robinson said it's a low sum for what appears to be a historic hack that Twitter said involved an insider.

"Given the scale of the compromiseI don't think that's very much, but what we often see with these type of exploits is that the exploititself can be very sophisticated but they're not very good at monetizingit," Robinson said.

The scammers posted three separate bitcoin addresses and one address for the cryptocurrency Ripple, which didn't receive any transactions, Robinson said.

The largest transaction received by the scammers was one payment of about $42,000, which could be traced back to a Japanese cryptocurrency exchange, Robinson told CNBC.

CNBC could not verify who sent the bitcoin or if all of the money was proceeds from the scam. It's possible the scammers sent money to their own wallet to make their con look more successful.

Robinson said the people who fell for the racket were "a strange segment."

"It's people who are sophisticated enough to have crypto in the first place because otherwise they probably wouldn't have been able to make the payments in that short period of time, but also not crypto sophisticated enough to recognize the scam," Robinson said.

Shortly after the wallet started receiving funds, it started transferring them to different addresses. Robinson says that the scammers are probably doing this to "cash out." There could be benefits to moving fast before exchanges where cryptocurrency can be traded for cash or other coins block the addresses, he said.

Gemini, a major U.S. exchange, said it blacklisted the affected bitcoin addresses on Wednesday.

The scam tweets posted on Wednesday are similar to past scam tweets asking for bitcoin, with one major difference: The attackers were able to post them from compromised verified accounts with lots of followers.

Elon Musk's Twitter account was the first high-profile account to post a bitcoin tweet. Crypto scammers have targeted Musk in the past by creating dummy accounts that emulate Musk's account name and profile picture. They use those dummy accounts and reply to Tesla or SpaceX tweets asking for bitcoin.

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Twitter hackers who targeted Elon Musk and others received $121,000 in bitcoin, analysis shows - CNBC

Elon Musks Crew Dragon spaceship will bring Nasa astronauts home next week in historic first ever missi – The Sun

NASA has revealed a tentative date for bringing astronauts Bob Behnken and Doug Hurley back to Earth.

The US astronauts made history last month when they were the first to be sent to the International Space Station on a SpaceX spacecraft.

A Nasa and SpaceXFalcon 9 rocket shot two US astronauts into space back in May.

The launch was a historic event because it was the first time a private company launched astronauts into space.

It was also the first time in almost a decade that astronauts blasted off from US soil.

The astronauts piloted their Crew Dragon capsule all the way to the ISS and now Nasa is aiming to have them fall back to Earth in it by August 2.

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Nasa administrator Jim Bridenstine tweeted: "We're targeting an Aug. 1 departure of @SpaceX's Dragon Endeavour spacecraft from the @Space_Station to bring @AstroBehnken and @Astro_Doug home after their historic #LaunchAmerica mission.

"Splashdown is targeted for Aug. 2. Weather will drive the actual date. Stay tuned."

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The capsule is intended to splash into the Atlantic ocean after blazing through the atmosphere.

It should undock from the ISS on August 1 and thrust itself back down before re-entry which should see parachutes help it to soften the impact.

The astronauts will then be met by boats in the Atlantic Ocean.

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This landing has already been tested by an unmanned Dragon Crew capsule that made a safe re-entry last year.

Astronauts Behnken and Hurley have been helping out at the ISS since May 31, changing ageing batteries on space walks and assisting with scientific work.

The current plan is for them to undock from the ISS at 8pm ET on August 1.

This will be midnight in the UK.

However, weather and other factors can affect when astronauts can land back on Earth so this date and time is only provisional.

What is SpaceX?

Here's what you need to know...

SpaceX was founded by billionaire entrepreneurElon Muskwho still has part ownership of the company with 54 per cent equity and 78 per cent voting control.

SpaceX is a private American aerospace manufacturer that is based in California.

It was founded in 2002 with the goal to build affordable rockets and enable the colonisation of Mars.

The manufacturer also aimed to reducespacetransportation costs.

Since its creation, the firm has gained fame primarily as a pioneering rocket firm.

In 2008 it launched the first privately-funded liquid-propellant rocket to reach orbit and later became the first private company to launch an object into orbit around the sun.

The company has grown dramatically over its lifespan, from 160 employees in November 2005 to around 7,000 as of November 2019.

As of March 2018, SpaceX had over 100 launches on its manifest representing about $12billion (9.24billion) in contract revenue.

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In other space news, aliens are living in underground tunnels on Mars formed by lava billions of years ago, experts suspect.

Elon Musk announced last month that SpaceX's mission to get man on Mars is now the company's"top priority".

And, Nasa has revealed thedesign of a moon landerthat could be taking astronauts back to the lunar surface by 2024.

Would you like to go to the International Space Station? Let us know in the comments...

We pay for your stories! Do you have a story for The Sun Online Tech & Science team? Email us at tech@the-sun.co.uk

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Elon Musks Crew Dragon spaceship will bring Nasa astronauts home next week in historic first ever missi - The Sun

Following Funds From The Twitter Hack & Bitcoin Scam – Affecting Joe Biden, Elon Musk, And Others – Forbes

A massive hack affected Twitter around 3pm EDT Wednesday (July 15th 2020), in which many high-profile accounts were used to tweet out a large-scale doubling scam.

It is unclear exactly how the hackers gained access to make the tweets from these accounts, but Twitter posted an update which corroborated reports that indicated company personnel and internal admin tools were involved.

Considering that the hackers had control over some of the most influential accounts on Twitter, posting a simple Bitcoin scam and exposing their access is a curious choice. As Kris Holt said, It could have been a lot worse - Accounts were frozen quickly, and the main known hacker address only received around $120,000 worth of BTC at the time of writing. Tracking these funds, however small the amount, is important and the FBI is reportedly investigating:

Tracking Funds

Bitcoin is a public blockchain, so anyone can pull and investigate all of the hack-associated transactions and addresses from their own node. Zach Finzi and I use this publicly available blockchain data to model the funds received and subsequently sent by the scammer(s).

Bitcoin Network Topology Visualization Twitter Hack/Cryptoforhealth Scam

The above graph uses the 3d Network Topology App for Splunk SPLK s Machine Learning Tool Kit. It shows the indexed transactions between addresses implicated in the scam. Each node represents an individual address and the edges represent a set of transactions and transfers of BTC between the two nodes. Blue nodes are those linked to the Twitter hack, and blue edges represent transactions between them. Green edges represent funds received by the hacker(s), and orange ones show where they sent their funds.

To better visualize the movement of funds we can use a Sankey diagram:

Sankey Diagram of BTC transactions associated with the Twitter Hack

In the above image, transaction directionality can better be seen (BTC moves from addresses on the left to those on the right). To reduce complexity, not all transactions or addresses are pictured.

Here, we can see that the scammer(s) consolidates funds received by apparent victims, before dispersing them to others. Visualizations like these, in addition to various algorithms, are often used in blockchain forensics to help analysts link address ownership/affiliation.

By aggregating the addresses controlled by the scammer(s) to a single representative wallet, and further limiting the number of transactions displayed (for better viewing), we can see that the addresses which directly received payments have been mostly emptied to a number of other addresses.

The primary address which the scammer collected payments with, and was linked on the cryptoforhealth website, before it was pulled down, can be tracked by anyone here.

Sankey Diagram with Twitter Scam addresses aggregated

The addresses which now hold these funds can further be monitored in an attempt to see if they eventually are transferred to a known entity such as a regulated cryptocurrency exchange or gambling service, and to prevent the spending or laundering of them.

Natural Language Processing of Bitcoin Scam/Hack Events

Due to the high-profile nature of the accounts hit, the large security concerns that come with such an attack are perhaps more important than the missing $120k.

By combining techniques such as keyword detection, topic modeling, sentiment analysis, and named-entity recognition, I analyze natural language data surrounding Bitcoin. The below graphs shows unique document URLs (which are equivalent to unique articles, but also can contain structured text derived from images or videos) which contain the key term Bitcoin (and its aliases, such as BTC) and have topics related to scam, fraud, or hack.

The first image shows a daily count of the number of documents with the above criteria sorted by average term sentiment (that is sentiment in relation to the term Bitcoin). Expectedly, we can see a massive spike on July 15th and 16th.

Bitcoin Scam/Hack timeseries data from June 16th to July 16th 2020

By taking these filtered Bitcoin mentions, and limiting to only events from July 15th and 16th, we can see a highly negative average term sentiment (23.844%, where 0 is highly negative and 100 is highly positive). We also see that our models detect many mentions in these events for the high profile individuals whose accounts were compromised in this Hack:

Bitcoin Scam/Hack data from July 15th to July 16th 2020

Metadata about the information used in below panels (top). Top mentioned person name candidates identified through our neural nets (left). The overall sentiment for the term Bitcoin (right).

Despite the negative attention directed at Bitcoin, the incident does not imply any underlying security concerns for the Bitcoin network itself. In fact, the cryptofinancial ecosystems response to the hack has included spreading awareness of the scam, cooperative investigating of the activity, and reporting of the implicated addresses.

Bitcoinabuse.com, a site for self reporting of fraud-associated addresses, quickly received a number of reports for the scam addresses:

Twitter Hack Associated Addresses Bitcoinabuse Reports

Originally posted here:

Following Funds From The Twitter Hack & Bitcoin Scam - Affecting Joe Biden, Elon Musk, And Others - Forbes

How Oak Trees Evolved to Rule the Forests of the Northern Hemisphere – Scientific American

If you were dropped into virtually any region of North America 56 million years ago, you probably would not recognize where you had landed. Back then, at the dawn of the Eocene epoch, the earth was warmer and wetter than it is today. A sea had just closed up in the middle of the Great Plains, and the Rocky Mountains had not yet attained their full height. The continent's plant and animal communities were dramatically different. In the Canadian High Arctic, which today harbors relatively few tundra plant species, year-round temperatures above freezing nurtured a rich and diverse flora; Ellesmere Island in far northern Canada, across from the northwestern coast of Greenland, was home to alligators and giant tortoises. What is now the southeastern U.S. was dominated by tropical rain forest, complete with primates. The northeastern U.S., for its part, ranged from broad-leaved (as opposed to needle-leaved) evergreen forest to deciduous forests of ginkgo, viburnum, birch and elm, among other species. The deciduous broad-leaved forests that now cover 11 percent of North America north of Mexico were in their infancy. But that was about to change, with the spread and extraordinary diversification of what would eventually become some of the most ecologically and economically significant woody plants in the world: the acorn-bearing, wind-pollinated trees we call oaks.

Over the course of some 56 million years, oaks, which all belong to the genus Quercus, evolved from a single undifferentiated population into the roughly 435 species found today on five continents, ranging from Canada to Colombia and from Norway to Borneo. Oaks are keystone species, foundational to the functioning of the forests they form across the Northern Hemisphere. They foster diversity of organisms across the tree of life, from fungi to wasps, birds and mammals. They help clean the air, sequestering carbon dioxide and absorbing atmospheric pollutants. And they have shaped human culture, feeding us with their acorns and providing wood to build our homes, furniture and ships. Indeed, oaks have proved so valuable to people that we have immortalized them in legends and myths for centuries.

Oaks are especially prominent in the Americas. Approximately 60 percent of all Quercus species live here. This astounding variety, along with the fact that the oaks in this region account for more forest tree biomass than any other woody plant genus in North America and Mexico, makes them the single most important group of trees in the continent's forests. To understand forests, thentheir biodiversity, food webs and contributions to human well-beingone must understand how oaks came to rule them. For decades scientists could only speculate about much of the evolutionary history of oaks because of gaps in their fossil record and limitations of the biomolecular techniques used to infer evolutionary events from the DNA of living organisms. But recent advances in genome sequencing and analysis have allowed us and our colleagues to reconstruct a detailed picture of the origin, diversification and dispersal of oaks. It is a remarkable evolutionary success story, one that will have important implications for predicting how these essential trees will fare in the face of climate changeand for developing management plans to ensure their survival.

The differences between major groups of oaks are readily apparent to even a casual observer. In the Americas, oaks are dominated by two evolutionary lineages that you may already know. One of these, the red oak group, is composed of species with bristle-tipped leaves. In most red oak group species, pollen takes a full year from the time it lands on the female flower to fertilize the seed, so that acornsthe fruits of these treespollinated in one year only ripen in the next. Species in the other major lineage, the white oak group, have no bristles on their leaves, and the leaves generally contain more soil-enriching nutrients when they fall than those of red oaks do. Also, white oak acorns almost all ripen the same year they are pollinated, sometimes germinating before they even fall. Gray squirrels preferentially cache red oak acorns to eat at a later date because they are less likely than white oak acorns to go bad before the squirrels can get back to them.

White oaks are also able to efficiently plug the water-conducting, tubelike cells called vessels in their wood with tyloses, balloonlike structures that seal the vessels as a barrier against deadly fungal diseases such as oak wilt. Red oaks are slower and sloppy in their defense. Consequently, white oaks have long served as wood for ships and wine barrels because the plugged vessels of the white oak species hold water more effectively than those of the red oaks. Chewing insects recognize the differences between red and white oaks, and most are adapted to favor either one or the other of these two groups. Even mycorrhizal fungi, which connect plant roots to soil nutrients, appear to recognize the differences between the two types of oaks: many favor symbiotic relationships with species in one lineage over the other.

When we get to the species level, however, closely related oaks are often difficult to tell apart. The variation within species, the result of both plastic responses of the trees to their environment and genetic variation between individuals, often appears to be as great as the variation between species. And oaks hybridize commonly within their group, be it the white or red lineages or any of the six other major lineages of oaks worldwide. These two factorshigh variation within species and ongoing hybridization between speciescomplicate classification.

Hybridization can also make it difficult to reconstruct the evolutionary history of oaks using traditional biomolecular techniques, which involve sequencing one or a few genes, because individual genes often trace different histories. Moreover, a single oak species may have hybridized with numerous different species, so that different genes record different aspects of this history across the geographical range of the species. The oak genome is thus a mosaic shaped by speciation and hybridization. The sequences of only one or a few genes cannot reveal the full history of speciation in oaks.

Two decades ago researchers had only the sequences of DNA from chloroplaststhe cell organelles that carry out photosynthesisand a few nuclear genes to go on. It was enough to discern the overall branching structure of the oak tree of life, but we could not see the arrangement of its endmost branches. In 2008 the three of us realized that new molecular techniques we were already using to study hybridization and the limits of species in the red oak group might also enable us to infer oak evolutionary history. Since then, we, in collaboration with colleagues around the world, have employed an approach called restriction-site associated DNA sequencing to read short regions of DNA from across the genome. We analyze these data using statistical methods that reconstruct the order in which species have branched from common ancestors and which ones have hybridized since that divergence. By marrying these analyses to fossil data, we can estimate the maximum ages of key events in oak evolutionary history. Despite the complex genetic history of oaks, we have been able to deduce much of the history of speciation in this group going back to the root of the oak tree of life.

We may never know precisely when or where the very first oaks arose, but roughly 56 million years ago a population of oaks growing near what is now Salzburg, Austria, left in the mud a bit of the massive amount of pollen they produced each spring. These pollen grains, which are shaped like a rugby ball with three grooves running lengthwise and with surface textures that vary by lineage, are the earliest unambiguous fossil evidence of oaks on record. Throughout the early Eocene, land bridges spanning the Atlantic and Pacific Oceans connected North America and Eurasia. Plants and animals freely crossed between the two continents. Oaks were most likely part of a vast forest that spread across the continents of North America, Europe and Asia. This makes it difficult to say with any confidence whether oaks originated in Eurasia and sent a branch off to the Americas, or vice versa. The better answer to where modern oaks arose may simply be in the north.

In any case, remarkably soon after they arose, oaks started to separate into two major branches: one limited to Europe, Asia and North Africa and the other largely limited to the Americas. The separation between continents was imperfect at first. For example, the oldest fossil attributable to the ring-cupped oaks, based on the concentric rings formed by the woody scales on its acorn cap, was deposited in Oregon around 48 million years ago. Today this lineage is restricted to Southeast Asia. And red oaks, which today are an American group, have been reported from fossil sites in Europe dating to some 35 million years ago. But when global temperatures started their long descent about 52 million years ago, oaks were gradually pushed southward, away from the land bridges that have connected Eurasia and North America intermittently over the past 50 million years. As cooling drove northern oak populations extinct, the divisions between the two continents became very clean, with no species from the Eurasian clade showing up in the Americas and only two branches of the American clade showing up in Eurasia.

Before they could be pushed too far to the south, oaks were further subdivided into the eight major lineages we recognize in modern forests. Three of them are restricted to the Americas: the red, golden cup and southern live oaks. One lineage, that of the white oaks, originated and diversified in the Americas but sent an offshoot back to Eurasia. We know these major lineages arose early in oak evolution because one of the oldest American oak fossils is a 45-million-year-old white oak from Axel Heiberg Island in Nunavut, Canada, that can be distinguished from the red oaks and all other major lineages of oaks. But fossils from this initial phase of diversification are hard to assign to any one lineage, so we rely on molecular data to estimate when the other oaks separated into independent lineages. The integration of molecular data with selected fossils indicates that the world's eight lineages split early on. It is an important part of the story because it explains what happened next as the North American oaks underwent their own burst of diversification.

As temperatures cooled worldwide, the North American climate also became more seasonal. The Rocky Mountains were continuing to rise, and their rain shadow dried out the Great Plains. The tropical forests and broad-leaved evergreen forests that had flourished across North America were gradually restricted in range and driven to extinction by around 40 million years ago. Oak pollen and leaf impressions became more common in the North American fossil record 35 million years ago, by which time decreased temperatures and increased seasonality had converted North America north of Mexico from a mostly tropical to a mostly temperate continental landscape. As climate change extirpated tropical forests from North America, ecological opportunity arose for the oaks.

The red and white oaks moved south into this newly opened territory, each splitting into a lineage on the western side of the Rocky Mountains that gave rise to the modern-day oaks of California and the Pacific Northwest and into a lineage on the eastern side of the Rockies that gave rise to the oaks of eastern North America. Within the latter region, each of these major oak groups subdivided into a predominantly northeastern lineage, a predominantly southeastern lineage and a primarily Texan lineage. From eastern North America, perhaps by way of Texas, the red and white oaks then moved into Mexico between 10 million and 20 million years ago.

In all these areas, palms and broad-leaved evergreen trees had been pushed south or driven partially or wholly extinct by the cooling and increasingly fluctuating climate. The resulting abundance of open habitat enabled oaks to diversify. Increased ecological opportunity allowed oaks to undergo an adaptive radiation, in which nascent species rapidly fill spaces that other species are not occupying. In doing so, these young populations became more ecologically distinct from one another, thereby limiting the movement of genes between them. They became reproductively isolated, so that genes moved less between separated populations than among trees within populations. Subsequently, new genetic mutations and rearrangements could accumulate that distinguished the populations from one another. Through this process, they became new species.

This adaptive radiation played out most dramatically in Mexico and Central America, where about 40 percent of all the world's oaks reside. Recall that oaks were a largely cold-adapted lineage that spread across the continent as temperatures dropped and seasonality increased. As they migrated south into Mexico, oaks climbed to higher elevations that more closely resembled the temperate biome in which they had evolved, and they encountered high topographic variation that readily separated them into reproductively isolated populations. Oaks also evolved more rapidly along the continuum from low water availability to high water availability as they moved into Mexico. Tacking up and down the mountains, different populations adapted to different levels of drought. This ecological differentiation most likely worked hand in hand with increased physical separation to promote reproductive isolation between populations.

Thus, the reason for the high oak diversity in Mexico appears not to be warmer temperatures. And because Mexican oaks are relatively young, their high diversity has not accrued over comparatively long periods of evolutionary time. Rather adaptive radiation led to higher speciation rates in these evolutionarily young Mexican oaks as they moved into the mountains. This change suggests that if oaks had been suited to climb into the Rockies and flourish therethat is, if they could have survived the combination of short growing seasons and cold winters of the northern mountainsthey might have developed high diversity in this region as well. Their evolutionary heritage simply did not equip them for these extremely harsh environments. Only a lone white oak species, the Gambel oak (Quercus gambelii), even comes close, and that species is limited to the southern Rockies.

The oaks were finally stopped in their march southward, perhaps by dramatic reduction in seasonality or strong competition from tropical forest species, only barely making it across the Isthmus of Panama into the north of South America. Yet this is not the whole story. The oaks' southward journey actually played out twice, simultaneously and in the same places. Because white and red oaks had already separated from each other by the time they started moving south, this diversification history happened in parallel in both the red and white oaks. Two distinct but very closely related lineages, not one, traced the biogeographical history we just described: moving south, splitting around the Rocky Mountains, heading into Mexico from an eastern North American ancestor. This history may explain part of the species richness and abundance of oaks in the Americas. They essentially double-dipped as they ventured south.

One of the most exciting areas of our research has been the integration of a genome-level understanding of the oak tree of life with physiological studies of oak adaptation to climate and habitat and community studies of oak forest structure. As oaks spread south and diversified in different regions, the white and the red oaks encountered similar habitats and repeatedly solved the same ecological problems in novel ways. As a result, we often find red and white oaks growing together in the same habitats. For example, on poor rocky soils and bluffs in the eastern U.S., you can find the white oak Quercus stellata, also known as the post oak, growing next to the red oak Quercus marilandica, commonly called the blackjack oak. In the mountains of southern Arizona, the iconic white oak Quercus arizonica often grows beside the red oak Quercus emoryi.

This pattern of oak co-occurrence is found in wooded plant communities across much of the country, and it has another intriguing feature. Whereas distantly related oaks tend to grow together, closely related oaks within lineages tend not to be found together. Along an elevational gradient in the Chiricahua Mountains of southern Arizona, for example, white oak species pass the baton as you walk upslope, transitioning broadly from one to the next as you hike uphill, and red oak species do as well. In the lowlands of Florida, white oak species separate across the sandhill, scrub and ravine habitats shaped by karst topography and fire. Red oaks do the same.

What shapes this pattern of oak co-occurrence? Ecological differentiation within the red and white oaks is influenced in part by the fact that no single species is able to master every habitat. Instead species tend to specialize on a limited part of the available ecological space. In oaks, physiological trade-offs within each lineage subdivide habitat and climatic space so that close relatives are less likely to co-occur. In the Chiricahua Mountains, for instance, drought adaptation separates close relatives along the elevation gradient. Species living near the bottom of the mountain are particularly good at avoiding drought, dropping their leaves during dry seasons. Species living at higher elevation, where there is more overall moisture, focus on surviving daily fluctuations in water availability by allowing leaf water content to drop lower before they suffer damage.

In contrast, in Florida, which is comparatively flat, soil moisture availability and fire intensity structure oak communities. Closely related species in these communities show trade-offs between growth rate and drought tolerance along moisture gradients and between bark thickness and the ability to reproduce via underground stems along gradients of fire intensity. In both regions, and indeed across the country, parallel trade-offs are found in both red and white oaks, and trees with convergent traits from the two lineages tend to grow together.

Members of different lineages may co-exist well with one another in each habitat because they differ in their susceptibility to disease: proximity to a more distantly related neighbor may be less likely to result in an epidemic because red and white oaks tend not to spread the same diseases. There is even evidence that oaks help one another get established and persist by creating a soil environment that benefits the mycorrhizal fungi they need to acquire nutrients. Then, once a forest has become established, oaks become dominant and prevent other kinds of trees from setting up shop. Our work makes clear that the evolutionary origins of oaks shape the complex ecological interactions that help to explain why the trees are so abundant and diverse in North America. The tree of life casts its shadow across the structure of our oak forests.

Now that we can delineate the branching history of the oak tree of life in some detail, the trees' propensity to hybridize has become all the more interesting. People often think of hybridization as a destructive force, eroding genetic differences between species. Yet oaks form what is called a syngameon, in which ecologically and physically distinctive species persist in spite of ongoing gene flow. It has long been hypothesized that genes migrating between species of the syngameon might help oaks adapt to novel environments. Could, for example, genes that contribute to drought adaptation in the post oak migrate into the bur oak (Quercus macrocarpa) in the southern regions, where they co-occur, and help the bur oak adapt to the drying conditions it is expected to encounter under global warming? We know already that there is localized gene flow between oak species and that species differ in what genes they exchange depending on where on the landscape they are, what species they co-occur with, and the climate and habitat in which the trees are growing. We also know that after genes move from one species into the other, they can move beyond the range of the species in which they arose, apparently propelled by environmental selection. These examples suggest that adaptive gene flow may play an important role in oak evolution. We are on the cusp of the integrative genomic and ecological studies needed to understand this process in depth.

We would still like to know what genes and attributesflowering time, habitat preference, geographical distancedrive speciation in oaks and whether ecological differences evolve while populations are growing together or only when they are separated. We are close to understanding what genes shape differentiation. Recent work in European oaks shows that genes influencing both their ability to cross-pollinate and their ecological preferences (for instance, tolerance of drought, cold and disease) are involved in species differentiation. Yet these findings only tell us that ecological differences evolve in species, not that they drive species differences. Statistical analyses that simulate alternative speciation histories suggest that in a group of four widespread European white oaks that hybridize today, the genomic differences between the species arose when the species were born in different geographical areas, with opportunities for gene flow arising only after the fully formed species migrated back into contact with each other. Still, the high degree of species co-occurrence in the American oaks raises the question of whether hybridization contributed to their diversity.

A firm grasp of when, where and how oaks came to be so diverse is crucial to understanding how oaks will resist and adapt to rapidly changing environments. Oaks migrated rapidly as continental glaciers receded starting around 20,000 years ago, and hybridization between species appears to have been key to their rapid response. The insights we can gain from elucidating the adaptive benefits of gene flow are critical to predicting how resilient oaks may be as climate change exposes them to fungal and insect diseases with which they did not evolve. As insects that transport pathogenic fungi increase their ranges and change their patterns of reproduction with earlier springs, oaks may have trouble holding their ground unless they can evolve quickly enough to resist diseases they have never before encountered. Our challenge for the coming decade as plant biodiversity scientists will be to figure out how differentiation between species and movement of genes between those species will influence the trajectory of oak evolution and population persistence. If we understand these processes well enough, we stand a chance of using that knowledge to predict what our forests will look like a century or more from now. Perhaps it can guide our plans to manage longer-term survival of the vital oaks.

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How Oak Trees Evolved to Rule the Forests of the Northern Hemisphere - Scientific American

Malaria: HKUMed and Institut Pasteur collaborate to use an evolution in a test tube approach to develop new molecules for diagnosis – Outbreak News…

The LKS Faculty of Medicine of The University of Hong Kong (HKUMed) has collaborated with Institut Pasteur, Paris, to develop an approach to evolve molecules which are entirely alien to biology. The researchers have demonstrated the approach by evolving molecules which stick to a malaria biomarker. Critically, these special non-biological molecules are able to carry out tasks which normal biological molecules are intrinsically unable to do. These molecules can, for example, be used to determine the type of malaria with which a patient is infected. The research has just been published inProceedings of the National Academy of Sciences of the United States of America (PNAS), a top journal in the field of multidisciplinary science.

One of the lead researchers of the study, Professor Julian Tanner, Professor and Associate Director (Teaching & Learning) of the School of Biomedical Sciences, Assistant Dean (Biomedical Sciences Curriculum), HKUMed, remarked, Evolution is a powerful idea that is at the centre of all of biology. This study harnesses the evolutionary idea of natural selection, but then applies it outside of the biological context, thus creating an evolution in a test tube approach. One can then use evolution instead of design to develop molecules which can solve challenges in diagnostics and therapeutics. If we can extend evolution well beyond the usual confines of biological molecules such as DNA and protein, then we can open an entire new toolbox which can transform medicine.

Background

Evolution is understood in biology as the process by which characteristics of organisms are inherited over successive generations under particular selective pressures. Evolution is guided by chance some members of a population are able to outcompete others which over time define the physical characteristics and behaviour of a species.

It is also possible to apply evolutionary selections to populations of molecules. In a similar fashion, molecules can be made to compete with each other for a particular characteristic. For example, this characteristic might be sticking to specific molecular markers which only exist in the presence of a disease. Such evolved molecules could then be used in diagnosing or treating a disease. This has previously been demonstrated for common biological molecules including DNA and proteins. However, it has always been a challenge to extend the idea of molecular evolution much beyond common biological molecules.

Study ResultsThe major challenge the team faced was how to develop an approach to allow point-of-care diagnosis of malaria that could distinguish when a patient is infected withPlasmodium falciparumparasites orPlasmodium vivaxparasites. This is important as the two parasite species cause malaria with different outcomes and typically require different drug treatments. However, the point-of-care approaches which had previously been developed for malaria diagnosis typically were only able to determine whether a patient had malaria, but were unable to distinguish which parasite had caused the malaria.

To solve this challenge, the team developed and applied an entirely new approach where unusual cube chemistries, called cubanes, are included into DNA, and integrated into an evolution in a test tube approach. Cubanes are never observed in biology, and hence this is a rare example of applying evolutionary principles to an entirely non-biological system. The research team discovered new types of DNA incorporating these unusual cubane chemistries which perfectly fit the binding pocket of a malaria biomarker which specifically indicatePlasmodium vivaxmalaria infection.

Read more at HKUMed

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Data Modeling Software Market Predicted to Witness Sustainable Evolution in Years to Come | SAS, IBM, Symbrium, Coheris, Apteco – 3rd Watch News

Latest released the research study onGlobal Data Modeling Software Market, offers a detailed overview of the factors influencing the global business scope.Data Modeling SoftwareMarket research report shows the latest market insights, current situation analysis with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of theData Modeling Software Market. The study covers emerging players data, including: competitive landscape, sales, revenue and global market share of top manufacturers.

Top players in Global Data Modeling Software Market are:

SAS Institute Inc. (United States),IBM (United States),Symbrium (United States),Coheris (France),Apteco (United Kingdom),Megaputer Intelligence Inc (United States),Mozenda, Inc (United States),GMDH (United States),Optymyze (Singapore),RapidMiner, Inc. (United States),Salford Systems (United States)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/111873-global-data-modeling-software-market

Keep yourself up-to-date with latest market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in Data Modeling Software Market various segments and emerging territory.

Brief Overview on Data Modeling Software

Data modeling is the method of applying techniques and methods according to the requirements of data so as to convert it in a useful form. Data modeling software helps in making a data model for any information system by applying a certain set of formal techniques. The software helps in the process of converting complex designs into an understandable, simple and easy diagram with the flow of data. In other words, in order to store data in a database, it needs to be converted into a particular form i.e. a data model is required and created for this purpose. Thus data modeling software permits drawing diagrams because it is easy for connecting and understanding data in a diagrammatical manner. Data modeling software is used in practice in many areas such as in business process modeling that usually deals with larger business processes and also the decision making the flow of the hierarchy of the entire organization.

The Global Data Modeling Software Market segments and Market Data Break Down are illuminated below:

Study by Application (Large Enterprises, Small and Medium-sized Enterprises (SMEs)), Package Type (One Time, Yearly, Quarterly, Others), Deployment Type (Cloud-based, On-premises), End-User (Government & Public Utilities, Healthcare, Industrial End-user Manufacturing, Retail & Consumer Goods, Aerospace & Defense, Others), Operating System (Windows, Cross-Platform)

Market Drivers

Market Trend

Market Challenges

Market Restraints:

Market Opportunities:

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/111873-global-data-modeling-software-market

Strategic Points Covered in Table of Content of Global Data Modeling Software Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Global Data Modeling Software market

Chapter 2: Exclusive Summary the basic information of the Global Data Modeling Software Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Global Data Modeling Software

Chapter 4: Presenting the Global Data Modeling Software Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying the by Type, End User and Region 2013-2020

Chapter 6: Evaluating the leading manufacturers of the Global Data Modeling Software market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

Finally, Global Data Modeling Software Market is a valuable source of guidance for individuals and companies.

Data Sources & Methodology

The primary sources involve the industry experts from the Global Data Modeling Software Market including the management organizations, processing organizations, analytics service providers of the industrys value chain. All primary sources were interviewed to gather and authenticate qualitative & quantitative information and determine the future prospects.

In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weightage.

Get More Information: https://www.advancemarketanalytics.com/reports/111873-global-data-modeling-software-market

What benefits does AMA research study is going to provide?

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources; our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enables clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Contact Us:

Craig Francis (PR & Marketing Manager)AMA Research & Media LLPUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

Connect with us athttps://www.linkedin.com/company/advance-market-analyticshttps://www.facebook.com/AMA-Research-Media-LLP-344722399585916https://twitter.com/amareport

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Data Modeling Software Market Predicted to Witness Sustainable Evolution in Years to Come | SAS, IBM, Symbrium, Coheris, Apteco - 3rd Watch News

Cloud Tax Management Market Predicted to Witness Sustainable Evolution in Years to Come | Avalara, Automatic Data Processing, Wolters Kluwer, Thomson…

Latest released the research study onGlobal Cloud Tax Management Market, offers a detailed overview of the factors influencing the global business scope.Cloud Tax ManagementMarket research report shows the latest market insights, current situation analysis with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of theCloud Tax Management Market. The study covers emerging players data, including: competitive landscape, sales, revenue and global market share of top manufacturers.

Top players in Global Cloud Tax Management Market are:

Avalara (United States),Automatic Data Processing (United States),Wolters Kluwer NV (Netherlands),Thomson Reuters (Canada),Intuit (United States),H&R Block (United States),SAP SE (Germany),Blucora (United States),Drake Enterprises (United States),TaxSlayer Pro LLC (United States)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/125667-global-cloud-tax-management-market

Keep yourself up-to-date with latest market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in Cloud Tax Management Market various segments and emerging territory.

Brief Overview on Cloud Tax Management

Cloud tax management is a service that automates all tax filings and efficiently manage all tax and non-tax obligations with the help of software solutions. It includes a simplified workflow for the tax professionals to manage project, tasks, issues and obligations and create paperless work environment. It address tax compliance requirement for tax professionals.

Recent Development in Global Cloud Tax Management Market:

In December 2019, Wolters Kluwer has introduced CCH Axcess Knowledge Coach, under its cloud-based tax preparation, compliance, and workflow management platform, CCH Axcess. This new solution provides auditors the flexibility of anywhere, anytime access, and improves the overall quality of auditing.

On February 13, 2019, TaxCloud, a leading online sales tax compliance service, and Bonanza, a seller-centric online marketplace focused on minimizing busywork for small businesses, has announced that they have partnered to offer TaxCloud services to Bonanza sellers to support their sales tax compliance.

The Global Cloud Tax Management Market segments and Market Data Break Down are illuminated below:

Study by Type (Indirect Tax, Direct Tax), Application (Automated Registration, Automatic Tax Filings & Remittance, Audit Response and Indemnification, Others), Deployment Type (Public Cloud, Private Cloud), Platform (Windows, Linux, IOS, Android, Others), Industry Vertical (Banking Financial Services and Insurance (BFSI), Information Technology (IT) and Telecom, Energy and Utilities, Healthcare and Life Sciences, Retail, Construction, Others), End-User (Individual, Professional), Component (Software, Services)

Market Drivers

Market Trend

Market Challenges

Market Restraints:

Market Opportunities:

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/125667-global-cloud-tax-management-market

Strategic Points Covered in Table of Content of Global Cloud Tax Management Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Global Cloud Tax Management market

Chapter 2: Exclusive Summary the basic information of the Global Cloud Tax Management Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Global Cloud Tax Management

Chapter 4: Presenting the Global Cloud Tax Management Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying the by Type, End User and Region 2013-2020

Chapter 6: Evaluating the leading manufacturers of the Global Cloud Tax Management market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

Finally, Global Cloud Tax Management Market is a valuable source of guidance for individuals and companies.

Data Sources & Methodology

The primary sources involve the industry experts from the Global Cloud Tax Management Market including the management organizations, processing organizations, analytics service providers of the industrys value chain. All primary sources were interviewed to gather and authenticate qualitative & quantitative information and determine the future prospects.

In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weightage.

Get More Information: https://www.advancemarketanalytics.com/reports/125667-global-cloud-tax-management-market

What benefits does AMA research study is going to provide?

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources; our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enables clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Contact Us:

Craig Francis (PR & Marketing Manager)AMA Research & Media LLPUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

Connect with us athttps://www.linkedin.com/company/advance-market-analyticshttps://www.facebook.com/AMA-Research-Media-LLP-344722399585916https://twitter.com/amareport

View post:

Cloud Tax Management Market Predicted to Witness Sustainable Evolution in Years to Come | Avalara, Automatic Data Processing, Wolters Kluwer, Thomson...

CAM Software Market Predicted to Witness Sustainable Evolution in Years to Come | Autodesk, Vero, Delcam, PTC, Siemens – 3rd Watch News

Latest released the research study onGlobal CAM Software Market, offers a detailed overview of the factors influencing the global business scope.CAM SoftwareMarket research report shows the latest market insights, current situation analysis with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of theCAM Software Market. The study covers emerging players data, including: competitive landscape, sales, revenue and global market share of top manufacturers.

Top players in Global CAM Software Market are:

Autodesk Inc. (United States),Vero (United Kingdom),Delcam (United Kingdom),PTC (United States),Siemens (Germany),Dassault Systemes (France),Cimatron (Israel),DP Technology (United States),Missler Software (France),NTT Data Engineering System (Japan),BobCAD-CAM (United States),Breton (Italy),JPS VETIGRAPH (France),LANG (Germany),Lantek Sheet Metal Solutions S.L (Spain),OPEN MIND (United States),TopSolid (France),ZWSOFT (China),SCHOTT SYSTEME GmbH (Germany)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/33655-global-cam-software-market

Keep yourself up-to-date with latest market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in CAM Software Market various segments and emerging territory.

Brief Overview on CAM Software

Computer-aided manufacturing (CAM) software is the tool which is used to automate the manufacturing processes. CAM software is in widespread use by the engineers, architects, designers for manufacturing and designing objects, specifically computer numerical control (CNC) machining. CAM is the result of the computer-aided process for both, computer-aided designing and computer-aided engineering. The model generated in CAD and tested in CAE can be the input for CAM software, which helps in controlling the machine tool. The main application of this tool is in controlling the manufacturing plant. the CAM software use assemblies formed to generate toolpath that drives machine tools to turn designs into the physical parts

Recent Development in Global CAM Software Market:

Vero to demonstrate new features for enhanced flexibility at SIANE 2018, Hexagon AB Acquires ProCAM, a Distributor of Vero Software Solutions in Italy

Delcam will demonstrate the latest versions of its PowerMILL CAM system and its PowerINSPECT inspection software at the BIMU exhibition

The Global CAM Software Market segments and Market Data Break Down are illuminated below:

Study by Type (2D, 3D), Application (Aerospace & Defense Industry, Shipbuilding Industry, Automobile & Train Industry, Machine Tool Industry, Others), Deployment model (On premises, Cloud based)

Market Drivers

Market Trend

Market Challenges

Market Restraints:

Market Opportunities:

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/33655-global-cam-software-market

Strategic Points Covered in Table of Content of Global CAM Software Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Global CAM Software market

Chapter 2: Exclusive Summary the basic information of the Global CAM Software Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Global CAM Software

Chapter 4: Presenting the Global CAM Software Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying the by Type, End User and Region 2013-2020

Chapter 6: Evaluating the leading manufacturers of the Global CAM Software market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

Finally, Global CAM Software Market is a valuable source of guidance for individuals and companies.

Data Sources & Methodology

The primary sources involve the industry experts from the Global CAM Software Market including the management organizations, processing organizations, analytics service providers of the industrys value chain. All primary sources were interviewed to gather and authenticate qualitative & quantitative information and determine the future prospects.

In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weightage.

Get More Information: https://www.advancemarketanalytics.com/reports/33655-global-cam-software-market

What benefits does AMA research study is going to provide?

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources; our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enables clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Contact Us:

Craig Francis (PR & Marketing Manager)AMA Research & Media LLPUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

Connect with us athttps://www.linkedin.com/company/advance-market-analyticshttps://www.facebook.com/AMA-Research-Media-LLP-344722399585916https://twitter.com/amareport

Here is the original post:

CAM Software Market Predicted to Witness Sustainable Evolution in Years to Come | Autodesk, Vero, Delcam, PTC, Siemens - 3rd Watch News

Cloud Based Private Branch Exchange Market Predicted to Witness Sustainable Evolution in Years to Come | Fusion Connect, Microsoft (Skype), Cisco…

Latest released the research study onGlobal Cloud Based Private Branch Exchange Market, offers a detailed overview of the factors influencing the global business scope.Cloud Based Private Branch ExchangeMarket research report shows the latest market insights, current situation analysis with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of theCloud Based Private Branch Exchange Market. The study covers emerging players data, including: competitive landscape, sales, revenue and global market share of top manufacturers.

Top players in Global Cloud Based Private Branch Exchange Market are:

Fusion Connect Inc. (United States),Microsoft (Skype) (United States),Cisco Systems (United States),Nextiva (United States),RingCentral (United States),Vonage (United States),3CX (United States),88 (United States),Avaya (United States),Barracuda Networks, Inc. (United States)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/109010-global-cloud-based-private-branch-exchange-market

Keep yourself up-to-date with latest market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in Cloud Based Private Branch Exchange Market various segments and emerging territory.

Brief Overview on Cloud Based Private Branch Exchange

The cloud-based PBX enables data traffic and voice communication traffic integration into a single network to reduce the total cost of ownership (TCO) associated with a combined voice or data network. The integration of multiple media types such as voice, data, and video into a single network eliminates infrastructure and maintenance redundancies, which also minimizes capital and operational costs. Also, cloud-based PBX increasingly demonstrates greater cost-effectiveness than traditional voice networks and increases the cost or benefit ratio, efficiency, and flexibility in implementation

The Global Cloud Based Private Branch Exchange Market segments and Market Data Break Down are illuminated below:

Study by Component Type (Solution, Services), Industry Verticals (IT, BFSI, Healthcare, Manufacturing, Retail, Government and Public Sector, Education, Others), System Type (PC Based, Mobile Based), Organisation Size (SMEs, Large Enterprise)

Market Drivers

Market Trend

Market Challenges

Market Restraints:

Market Opportunities:

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/109010-global-cloud-based-private-branch-exchange-market

Strategic Points Covered in Table of Content of Global Cloud Based Private Branch Exchange Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Global Cloud Based Private Branch Exchange market

Chapter 2: Exclusive Summary the basic information of the Global Cloud Based Private Branch Exchange Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Global Cloud Based Private Branch Exchange

Chapter 4: Presenting the Global Cloud Based Private Branch Exchange Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying the by Type, End User and Region 2013-2020

Chapter 6: Evaluating the leading manufacturers of the Global Cloud Based Private Branch Exchange market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

Finally, Global Cloud Based Private Branch Exchange Market is a valuable source of guidance for individuals and companies.

Data Sources & Methodology

The primary sources involve the industry experts from the Global Cloud Based Private Branch Exchange Market including the management organizations, processing organizations, analytics service providers of the industrys value chain. All primary sources were interviewed to gather and authenticate qualitative & quantitative information and determine the future prospects.

In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weightage.

Get More Information: https://www.advancemarketanalytics.com/reports/109010-global-cloud-based-private-branch-exchange-market

What benefits does AMA research study is going to provide?

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources; our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enables clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Contact Us:

Craig Francis (PR & Marketing Manager)AMA Research & Media LLPUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

Connect with us athttps://www.linkedin.com/company/advance-market-analyticshttps://www.facebook.com/AMA-Research-Media-LLP-344722399585916https://twitter.com/amareport

Read more:

Cloud Based Private Branch Exchange Market Predicted to Witness Sustainable Evolution in Years to Come | Fusion Connect, Microsoft (Skype), Cisco...

Saudi Arabia Manpower Outsourcing Market Predicted to Witness Sustainable Evolution in Years to Come – Cole of Duty

Manpower Outsourcing. Outsourcing is an application that a company has or has agreed with an external organization or service provider to perform certain operations or functions. India is always appreciated with its skilled manpower.

The Saudi Arabia Manpower Outsourcing marketis growing along with the Technology, Media and Telecommunications industry, but the market is likely to slow down its growth due to the shortage of skilled professionals, suggests the Business Market Insights report.

The Business Market Insights subscription helps clients understand theongoingmarket trends,identifyopportunities, and make informed decisions through the reports in the Subscription Platform. The Industry reports available in the subscriptionprovidean in-depth analysis on various market topics and enable clients to line up remunerative opportunities. The reportsprovidethe market size & forecast, drivers, challenges, trends, and more.

Get free trial subscription and gain instant access to our market research reports at https://www.businessmarketinsights.com/TIPRE00004114/request-trial

These factorsare expectedto offer broad growth opportunities in the Technology, Media and Telecommunications industry and this is expected to cause the demand forManpower Outsourcing assays in the market.

Business Market Insights reports focus upon clientobjectives, use standard research methodologies and exclusive analytical models, combined with robust business acumen, which providesprecise and insightful results.

Business Market Insights reports are usefulnot only forcorporate and academic professionalsbut also forconsulting, research firms,PEVCfirms, and professional services firms.

MANOPOWER OUTSOURCING SERVICES MARKET SEGMENTATION

By Type

By Industry

Company Profiles

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(30-day subscription plans proveto beverycost-effectivewith no compromise on the quality of reports)

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About Business Market Insights

Based in New York, Business Market Insights is a one-stop destination for in-depth market research reports from various industries including Technology, Media & Telecommunications, Semiconductor & Electronics, Aerospace & Defense, Automotive & Transportation, Biotechnology, Healthcare IT, Manufacturing & Construction, Medical Device, and Chemicals & Materials. The clients include corporate and academic professionals, consulting, research firms,PEVCfirms, and professional services firms.

For Subscription contact

Business Market Insights

Phone :+442081254005E-Mail :[emailprotected]

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Saudi Arabia Manpower Outsourcing Market Predicted to Witness Sustainable Evolution in Years to Come - Cole of Duty

Global Animation Market Predicted to Witness Sustainable Evolution in Years to Come – 3rd Watch News

The New Report Titled as Animation Market published by Global Marketers, covers the market landscape and its evolution predictions during the forecast period. The report objectives to provide an overview of global Animation Market with detailed market segmentation by solution, security type, application and geography. The Animation Market is anticipated to eyewitness high growth during the forecast period. The report delivers key statistics on the market status of the leading market players and deals key trends and opportunities in the market.

Request For Free Sample Report: @ https://www.globalmarketers.biz/report/technology-and-media/global-animation-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156882#request_sample

This research report also includes profiles of major companies operating in the global market. Some of the prominent players operating in the Global Animation Market are:

Intel CorpAdvanced Micro Devices IncSide Effects Software IncNemetschek SESmith Micro Software IncThe Walt Disney CompanyNewTek Inc.NVIDIA CorpBOXX Technologies IncWarner Bros. EntertainmentBlue Sky StudiosFramestoreDreamworksAutodesk IncCartoon Network Studios

The Animation Market for the regions covers North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. Regional breakdown has been done based on the current and forthcoming trends in the global Animation Market along with the discrete application segment across all the projecting region.

Ask For Discount: https://www.globalmarketers.biz/discount_inquiry/discount/156882

The Type Coverage in the Market are:

Motion CaptureStop Motion3D Animation MoviesOthers

Market Segment by Applications, covers:

Computer Generated Imagery (CGI)Web Animation2D AnimationCorporate ServicesVisual EffectsOthers

Some Major TOC Points:

Chapter 1. Animation Market Report Overview

Chapter 2. Global Animation Market Growth Trends

Chapter 3. Market Share by Key Players

Chapter 4. Animation Market Breakdown Data by Type and Application

Chapter 5. Market by End Users/Application

Chapter 6. COVID-19 Outbreak: Animation Industry Impact

Chapter 7. Opportunity Analysis in Covid-19 Crisis

Chapter 9. Market Driving Force

Continue for TOC

Do you want any other requirement or customize the report, Do Inquiry Here: https://www.globalmarketers.biz/report/technology-and-media/global-animation-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156882#inquiry_before_buying

Key questions Answered in this Animation Market Report:

What will be the Animation Market growth rate and value in 2020?

What are the key market predictions?

What is the major factors of driving this sector?

What are the situations to market growth?

Major factors covered in the report:

Global Animation Market summary

Economic Impact on the Industry

Animation Market Competition in terms of Manufacturers

Animation Market Analysis by Application

Marketing Strategy comprehension, Distributors and Traders

Study on Market Research Factors

Table of Content & Report Detail @ https://www.globalmarketers.biz/report/technology-and-media/global-animation-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156882#table_of_contents

See the article here:

Global Animation Market Predicted to Witness Sustainable Evolution in Years to Come - 3rd Watch News

Lab Automation Market Growth Evolution, Trends Innovation, Major Product Segment and Forecasts Report 2026| TECAN, PERKINELMER, THERMO FISHER…

Los Angeles, United State: The global Lab Automation market report offers fine intelligence that prepares market players to compete well against their toughest competitors on the basis of growth, sales, and other vital factors. The research study lays emphasis on key growth opportunities and market trends apart from critical market dynamics including market drivers and challenges. With the help of this report, interested parties can equip themselves to adapt according to the changes in the Lab Automation industry and secure a strong market position for years to come. The report provides market development statistics, a list of select leading players, deep regional analysis, and a broad market segmentation study to give a complete understanding of the global Lab Automation market.

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The report presents a detailed analysis of the competitive landscape along with company profiling of key players competing in the global Lab Automation market. The authors of the report make it a point to provide readers with a complete evaluation of the vendor landscape and inform them about current and future changes therein. The competitive analysis offered in the report includes market share, gross margin, product portfolio, consumption, market status, and technologies of leading players operating in the global Lab Automation market.

Key Players Mentioned in the Global Lab Automation Market Research Report: TECAN, PERKINELMER, THERMO FISHER SCIENTIFIC, AGILENT TECHNOLOGIES, DANAHER, QIAGEN, ROCHE, SIEMENS, EPPENDORF, BIOMERIEUX, ABBOTT LABORATORIES, HAMILTON ROBOTICS

Global Lab Automation Market by Type: Robotic Arms, Microplate Readers, LIMS

Global Lab Automation Market by Application: Biotechnology, Pharmaceuticals, Diagnostic Labs

The global Lab Automation market is segmented on the basis of type of product, application, and region. The analysts authoring the report provide a meticulous evaluation of all of the segments included in the report. The segments are studied keeping in view their market share, revenue, market growth rate, and other vital factors. The segmentation study equips interested parties to identify high-growth portions of the global Lab Automation market and understand how the leading segments could grow during the forecast period.

The report gives a broad explanation about the presence of the Lab Automation market in different regions and countries. With an extensive regional analysis of the Lab Automation market, the research analysts make an attempt to unveil hidden growth prospects available for players in different parts of the world. They accurately estimate market share, CAGR, production, consumption, price, revenue, and other crucial factors that indicate the growth of regional markets studied in the report. They also shed light on the presence of prominent players in regional markets, and how it is making a difference in the growth of the regional markets.

How can the research study help your business?

(1) The information presented in the Lab Automation report helps your decision makers to become prudent and make the best business choices.

(2) The report enables you to see the future of the global Lab Automation market and accordingly take decisions that will be in the best interest of your business.

(3) It offers you a forward-looking perspective of the global Lab Automation market drivers and how you can secure significant market gains in the near future.

(4) It provides SWOT analysis of the global Lab Automation market along with useful graphics and detailed statistics providing quick information about the markets overall progress throughout the forecast period.

(5) It also assesses the changing competitive dynamics of the global Lab Automation market using pin-point evaluation.

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Table of Contents

About Us:

QY Research established in 2007, focus on custom research, management consulting, IPO consulting, industry chain research, data base and seminar services. The company owned a large basic data base (such as National Bureau of statistics database, Customs import and export database, Industry Association Database etc), experts resources (included energy automotive chemical medical ICT consumer goods etc.

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Lab Automation Market Growth Evolution, Trends Innovation, Major Product Segment and Forecasts Report 2026| TECAN, PERKINELMER, THERMO FISHER...

Global Big Data in Healthcare Market Predicted to Witness Sustainable Evolution in Years to Come – 3rd Watch News

The New Report Titled as Big Data in Healthcare Market published by Global Marketers, covers the market landscape and its evolution predictions during the forecast period. The report objectives to provide an overview of global Big Data in Healthcare Market with detailed market segmentation by solution, security type, application and geography. The Big Data in Healthcare Market is anticipated to eyewitness high growth during the forecast period. The report delivers key statistics on the market status of the leading market players and deals key trends and opportunities in the market.

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This research report also includes profiles of major companies operating in the global market. Some of the prominent players operating in the Global Big Data in Healthcare Market are:

TableauOptumEpic System CorporationSASCiscoDellCognizantGE HealthcareMckessonCerner CorporationIBMSAPPhilips

The Big Data in Healthcare Market for the regions covers North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. Regional breakdown has been done based on the current and forthcoming trends in the global Big Data in Healthcare Market along with the discrete application segment across all the projecting region.

Ask For Discount: https://www.globalmarketers.biz/discount_inquiry/discount/156862

The Type Coverage in the Market are:

Financial analyticsClinical AnalyticsOperational AnalyticOthers

Market Segment by Applications, covers:

HardwareSoftwareProfessional Services

Some Major TOC Points:

Chapter 1. Big Data in Healthcare Market Report Overview

Chapter 2. Global Big Data in Healthcare Market Growth Trends

Chapter 3. Market Share by Key Players

Chapter 4. Big Data in Healthcare Market Breakdown Data by Type and Application

Chapter 5. Market by End Users/Application

Chapter 6. COVID-19 Outbreak: Big Data in Healthcare Industry Impact

Chapter 7. Opportunity Analysis in Covid-19 Crisis

Chapter 9. Market Driving Force

Continue for TOC

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Key questions Answered in this Big Data in Healthcare Market Report:

What will be the Big Data in Healthcare Market growth rate and value in 2020?

What are the key market predictions?

What is the major factors of driving this sector?

What are the situations to market growth?

Major factors covered in the report:

Global Big Data in Healthcare Market summary

Economic Impact on the Industry

Big Data in Healthcare Market Competition in terms of Manufacturers

Big Data in Healthcare Market Analysis by Application

Marketing Strategy comprehension, Distributors and Traders

Study on Market Research Factors

Table of Content & Report Detail @ https://www.globalmarketers.biz/report/business-services/global-big-data-in-healthcare-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156862#table_of_contents

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Global Big Data in Healthcare Market Predicted to Witness Sustainable Evolution in Years to Come - 3rd Watch News

Global Non-Slip Rubber Mats Market Predicted to Witness Sustainable Evolution in Years to Come – 3rd Watch News

The New Report Titled as Non-Slip Rubber Mats Market published by Global Marketers, covers the market landscape and its evolution predictions during the forecast period. The report objectives to provide an overview of global Non-Slip Rubber Mats Market with detailed market segmentation by solution, security type, application and geography. The Non-Slip Rubber Mats Market is anticipated to eyewitness high growth during the forecast period. The report delivers key statistics on the market status of the leading market players and deals key trends and opportunities in the market.

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This research report also includes profiles of major companies operating in the global market. Some of the prominent players operating in the Global Non-Slip Rubber Mats Market are:

WearwellRubber-CalAndersenULINEApache Mills3MBotronNew PigNoTraxCrown Matting Technologies

The Non-Slip Rubber Mats Market for the regions covers North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. Regional breakdown has been done based on the current and forthcoming trends in the global Non-Slip Rubber Mats Market along with the discrete application segment across all the projecting region.

Ask For Discount: https://www.globalmarketers.biz/discount_inquiry/discount/157002

The Type Coverage in the Market are:

Commercial UseHousehold

Market Segment by Applications, covers:

Water LeakRegular

Some Major TOC Points:

Chapter 1. Non-Slip Rubber Mats Market Report Overview

Chapter 2. Global Non-Slip Rubber Mats Market Growth Trends

Chapter 3. Market Share by Key Players

Chapter 4. Non-Slip Rubber Mats Market Breakdown Data by Type and Application

Chapter 5. Market by End Users/Application

Chapter 6. COVID-19 Outbreak: Non-Slip Rubber Mats Industry Impact

Chapter 7. Opportunity Analysis in Covid-19 Crisis

Chapter 9. Market Driving Force

Continue for TOC

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Key questions Answered in this Non-Slip Rubber Mats Market Report:

What will be the Non-Slip Rubber Mats Market growth rate and value in 2020?

What are the key market predictions?

What is the major factors of driving this sector?

What are the situations to market growth?

Major factors covered in the report:

Global Non-Slip Rubber Mats Market summary

Economic Impact on the Industry

Non-Slip Rubber Mats Market Competition in terms of Manufacturers

Non-Slip Rubber Mats Market Analysis by Application

Marketing Strategy comprehension, Distributors and Traders

Study on Market Research Factors

Table of Content & Report Detail @ https://www.globalmarketers.biz/report/chemicals-and-materials/global-non-slip-rubber-mats-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/157002#table_of_contents

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Global Non-Slip Rubber Mats Market Predicted to Witness Sustainable Evolution in Years to Come - 3rd Watch News

Global Energy Storagefor Microgrids Market Predicted to Witness Sustainable Evolution in Years to Come – 3rd Watch News

The New Report Titled as Energy Storagefor Microgrids Market published by Global Marketers, covers the market landscape and its evolution predictions during the forecast period. The report objectives to provide an overview of global Energy Storagefor Microgrids Market with detailed market segmentation by solution, security type, application and geography. The Energy Storagefor Microgrids Market is anticipated to eyewitness high growth during the forecast period. The report delivers key statistics on the market status of the leading market players and deals key trends and opportunities in the market.

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This research report also includes profiles of major companies operating in the global market. Some of the prominent players operating in the Global Energy Storagefor Microgrids Market are:

AmpardSAMSUNG SDIMoixaZENABBThe AES CorporationGESolarCityNECImergyYounicosAquion EnergyEOSPrincetonNGK GroupEnStorageOutBackSaftZBB EnergyA123 Energy SolutionsAbsolute Renewable Energy (UK) LtdAEGS&C Electric Company

The Energy Storagefor Microgrids Market for the regions covers North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. Regional breakdown has been done based on the current and forthcoming trends in the global Energy Storagefor Microgrids Market along with the discrete application segment across all the projecting region.

Ask For Discount: https://www.globalmarketers.biz/discount_inquiry/discount/156952

The Type Coverage in the Market are:

Military Base MicrogridsCommercial and Industrial (C&I) MicrogridsOther

Market Segment by Applications, covers:

Pumped StorageCAESFlywheel Energy StorageSMESBattery Energy StorageSuper Capacitor Energy Storage

Some Major TOC Points:

Chapter 1. Energy Storagefor Microgrids Market Report Overview

Chapter 2. Global Energy Storagefor Microgrids Market Growth Trends

Chapter 3. Market Share by Key Players

Chapter 4. Energy Storagefor Microgrids Market Breakdown Data by Type and Application

Chapter 5. Market by End Users/Application

Chapter 6. COVID-19 Outbreak: Energy Storagefor Microgrids Industry Impact

Chapter 7. Opportunity Analysis in Covid-19 Crisis

Chapter 9. Market Driving Force

Continue for TOC

Do you want any other requirement or customize the report, Do Inquiry Here: https://www.globalmarketers.biz/report/energy/global-energy-storagefor-microgrids-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156952#inquiry_before_buying

Key questions Answered in this Energy Storagefor Microgrids Market Report:

What will be the Energy Storagefor Microgrids Market growth rate and value in 2020?

What are the key market predictions?

What is the major factors of driving this sector?

What are the situations to market growth?

Major factors covered in the report:

Global Energy Storagefor Microgrids Market summary

Economic Impact on the Industry

Energy Storagefor Microgrids Market Competition in terms of Manufacturers

Energy Storagefor Microgrids Market Analysis by Application

Marketing Strategy comprehension, Distributors and Traders

Study on Market Research Factors

Table of Content & Report Detail @ https://www.globalmarketers.biz/report/energy/global-energy-storagefor-microgrids-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/156952#table_of_contents

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Global Energy Storagefor Microgrids Market Predicted to Witness Sustainable Evolution in Years to Come - 3rd Watch News

‘Palm Springs’ brings notion of repeated reality to life – The Daily Cardinal

As our COVID-riddled state rolls back openings and braces for whatever the months ahead hold, these past few weeks of Summer: Live from Wisconsin Quarantine! have started to feel like theyre simply repeating the same events every single day. Over and over and over again.

Hulus Palm Springs takes that notion literally and somehow makes us want to stick around.

In the largest Sundance Film Festival sale ever made, Palm Springs tells the story of family black sheep Sarah, an unlucky maid of honor who awakens on the morning of November 9 the day of her sisters wedding and prepares for whatever the fateful day entails. Played to the absolute piping brim of her Im a disappointment glory by How I Met Your Mother titular actress Cristin Milioti, Sarah quickly draws the attention of wedding guest and surprising toast giver Nyles, portrayed by Lonely Island and Brooklyn Nine-Nine star Andy Samberg, becoming smitten with his seemingly uncanny ability to predict everything exactly the way it will happen before it even happens.

The meet-cute between both parties ensues, the preparations for a night of romance abound before suddenly, all hell suddenly breaks loose. Nyles is struck by an arrow from a homicidal maniac, Sarah follows him towards a glowing cave, and before we know it, she wakes up in the same bed on November 9, all over again.

Unbeknownst to Sarah, Nyles has led her into a time loop, one in which hes been stuck for so long he stopped counting the days, and provides her the rules for how the new world operates. From a series of lackluster suicide attempts to a bucket list of crazy activities, the pair is forced to navigate whatever can be found in this new world for only the both of them, quickly recognizing theres no escaping their inevitable reset or budding romance along the way.

The beauty of Palm Springs doesnt lie in the formula a pattern weve seen perfectly patented through the 1993 classic Groundhog Day and more recently updated in films like Blumhouses Happy Death Day and television series like Netflixs Russian Doll.

Nyles isnt trying to convince other people that hes trapped like Phil Conners (Bill Murray) does, and theres no redeeming quality that has to be found inside either character before they can escape. Rather, its the unique blend of the formula we see here part and parcel existential comedy about the nothingness of repeating the same day and padding provided through will they or wont they romantic comedy tropes that works perfectly to let both characters recognize what theyve found in each other, saving the movie and preventing it from being a bad version of both. It causes viewers to ponder whether or not we would be content repeating the same day if it meant we got to spend it with someone we came to love, and once the twist comes youll be shocked to discover why Sarah feels the need to escape the cycle for good.

While the twists and turns of the narrative keep the engine moving, the performances on both sides make the on-screen romance far better than one couldve ever hoped. Samberg adopting more of a frat boy persona over his typical parody schtick brings a perfect level of hysterical hopelessness into the time loop situation, dialing up his chops for the moments of insanity and tapping into some more serious emotions once he recognizes the feelings hes developed for Sarah.

Had I not watched Lonely Island videos thousands of times in middle school much to the disappointment of my teachers and peers I wouldve never guessed he had the ability to change directions. Not to mention his chemistry with Milioti who brings her own manic energy to the screen and Sambergs performance propels the storyline far beyond anything a lower-tier comedian might have provided towards the role. Im excited to see him continue to tackle more projects like this as Nine Nine seemingly comes to a conclusion within the next few years and he hopefully lines himself up for the potential of a late-career Adam Sandler route for adult romantic comedies or just a few more Lonely Island videos, I would be fine with that.

Many of the supporting performances, from television legends like Peter Gallagher and teen stars like Camila Mendes, warrant some attention in Springs. They make or break a high-concept oftentimes, and while the starring pair does a great job keeping fans involved no one provides a fastball quite like Oscar-winner J.K. Simmons in roughly 8-10 minutes of screen time. Coming down from the clouds, and the occasional Travelers Insurance commercial, to play a wedding guest named Roy who develops a strange obsession, well call it with Nyles, Simmons adds yet another eccentric character to his lengthy resume as a supporting comedy player. He perfectly flips the switch between smarmy and sarcastic during the wedding scenes and genuinely warm hearted with his suburban family towards the end of the film, and it consistently blows my mind how frequently he finds new ways to deliver. Any role he takes could fall anywhere between Tom Hanks and a creepier version of Bryan Cranston making his performance in Springs one of the most surprising and enjoyable parts of the entire movie.

All in all, Palm Springs needs to be watched with as few spoilers and as open of a mind as humanly possible letting you sink your teeth into the concept and really imagining how you would really feel living the same day over and over again. Dont look up spoilers, dont deep dive quantum physics on YouTube and suspend disbelief for just a few or 90 moments and you might just find your new favorite comedy movie of the summer and rest of the year.

You can find Palm Springs streaming on Hulu right now.

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'Palm Springs' brings notion of repeated reality to life - The Daily Cardinal

DR. ROBERT WALLACE: Donate blood locally where it’s greatly needed – Goshen News

DR. WALLACE: I was thinking about donating blood. Is it dangerous? How do I get my blood back? Who gets to use my blood? Ive spoken to a lot of my friends who recently suggested we all help out our fellow citizens by donating blood. Potential New Blood Donor, via email

POTENTIAL NEW BLOOD DONOR: Now is definitely a great time to donate blood! Its not dangerous; your body will naturally produce more blood to replace what you donated, and some very thankful people will benefit from your gift.

You can, of course, contact one of the large national organizations to get more information about becoming a donor. But please dont forget to consider where you make your donation. There are many smaller regional and local organizations that would greatly appreciate your donation, which will then help others right in your own area.

A reader named Carol at the Community Blood Center of the Ozarks brought this important point to my attention recently. Please read her powerful message, and keep it in mind when you select the venue where youll be making your own donation. Here is Carols sage advice:

DR. WALLACE: Though I am well past 20 and have no children, I still enjoy reading your column. The advice you provide to young people is extremely valuable. I do have one bone to pick with you, concerning aligning yourself with only the Red Cross when it comes to blood donations. I realize that a lot of people think only of the Red Cross for this service, but there is an organization of independent community blood centers that actually contribute a larger percentage of all of the blood provided to hospitals across America. This organization is called Americas Blood Centers, or ABC.

Community blood centers support their local areas with the blood, platelets and plasma needed at their local hospitals. Donations made at these centers stay in the local community. I work for one of those centers. In southwest Missouri and northwest Arkansas, we are the exclusive provider of blood and blood products to our more than 40 hospitals and several air ambulance services. To put it plainly, if the people in our community donate to the Red Cross, no patients in our hospitals benefit from that donation, and our inventory suffers. There are places in the country where a community blood center is not available. By all means, give to the Red Cross if a community blood center does not exist. But if a community blood center is available, that is where the support should go.

Our center collects COVID-19 convalescent plasma, or CCP; the Red Cross in our area does not. You might want to know that the method for donating CCP is not the same as donating whole blood. It is an apheresis product, and the process takes longer. You also must have the veins to support the back flow.

I hope you will consider this and not leave local centers out going forward!

DR. WALLACE: Im a fairly short 14-year-old girl, and I already weigh 148 pounds! I think that Im too fat and should maybe go on a diet, but my mom says that Im too young to diet and I will simply lose my baby fat as I grow older. Both my mother and father are quite a bit overweight, as they dont eat too many healthy meals, and they absolutely eat too much.

Im afraid if I dont start dieting pretty soon, Ill get really, really big, and my social life will be ruined before it ever has a chance to get started. Concerned Girl, via email

CONCERNED GIRL: If you feel that you have been following an unhealthy diet, then the time has come to change your eating habits and focus on more nutritious foods. If you continue along with your parents unhealthy eating patterns, you will probably wind up with a body shape similar to that of your mother or father.

Its imperative that your parents have you get a complete physical from your family doctor and then ask for a recommendation to see a nutritionist who will offer a healthy and delicious eating plan. It would be wise for Mom and Dad to join in and do the same, if possible.

I commend you for being so aware of and interested in your health at such a young age. This diligence and attention to detail will serve you well throughout your lifetime. Do follow up with a healthy eating plan, and dont forget that regular exercise is another big factor of a healthy lifestyle.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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DR. ROBERT WALLACE: Donate blood locally where it's greatly needed - Goshen News

PeaceHealth says elective surgeries returning to pre-pandemic levels – The Reflector

After a short time not offering elective surgeries due to COVID-19 concerns, staff at PeaceHealth Southwest Medical Center in Vancouver are seeing surgery numbers returning to pre-pandemic levels.

PeaceHealth Southwests Chief Medical Officer Lawrence Neville said it is gratifying to see the number of elective surgeries return to normal because many of these surgeries can greatly improve the quality of life for the patients.

According to Neville, an elective surgery is labeled as anything that can be put off for more than 30 days without death. Elective surgeries also fall into the category of non-emergent surgeries that can be scheduled and planned. Examples of elective surgeries include knee and joint replacements, ligament repairs and bariatric surgery. While these surgeries arent directly saving the life of the patient, Neville explained that elective surgeries can improve the quality of life for a patient as well as preventing future emergency surgeries. Bariatric surgeries, for example, dont directly save the life of an obese patient but puts them on the road to recovery and a healthy lifestyle, preventing possible emergency surgeries in the future.

Neville credited the recent levels of elective surgeries to health and safety measures the hospital is taking to ensure the safety of patients and staff. During the beginning of the pandemic, many patients avoided going in for medical care even after Gov. Jay Inslees order preventing them was lifted.

Unfortunately, a lot of folks put off getting treated and suffered consequences for doing so, Neville said, mentioning that a patient of his suffered a heart attack at home and didnt come into the emergency department for a couple of days. By the time the patient sought care, they were experiencing heart failure.

To ensure the safety of patients and staff and a return to care, Neville said the hospital has implemented many safety and health protocols. As well as having a mask requirement, each patient going in for an elective or emergent surgery is tested for COVID-19 so the staff can better treat the patient and protect themselves from potential harm. Visitors and patients are screened with temperature checks and COVID-related health questions before entering the hospital.

Neville said he was excited to allow patients to bring visitors into the hospital again. For the past couple of months, visitors have been restricted due to coronavirus.

Its really nice to have a family member with you when you have an overnight surgery, he said.

Along with these protocols, staff and patients exposed to and working with COVID-19 are in a separate ward of the hospital to protect other members. According to Neville, the COVID area of the hospital is on a completely different air system than the rest of the facility and staff working in the COVID area have many different health codes and training to adhere to to ensure protection of staff and clients. Neville also said the hospital is working to increase the training and protections of the COVID unit because it is expected that cases will continue to be high until a vaccine is created.

Its very different to work in a COVID unit, Neville said, mentioning that staff in COVID units wear full personal protective equipment and can get very hot. We have increased our training program to better protect the patients and staff Including making sure we have support people that can get providers water and the support they need.

To learn more about PeaceHealth medical center and their COVID-19 preparedness, visit peacehealth.org/coronavirus

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PeaceHealth says elective surgeries returning to pre-pandemic levels - The Reflector

Cristiano Ronaldo Advertises Herbalife As Nutrition To His Success – TheThings

Portuguese football player Cristiano Ronaldo clearly lives a healthy lifestyle, considering his excellent physique, so he's promoting Herbalife.

When it comes to playing professional sports for a living, athletes have to keep their bodies in the best shape possible. Portuguese football player Cristiano Ronaldo clearly lives a healthy lifestyle, considering his excellent physique.

The UEFAs Mens Player Of The Year 2016/2017 winner, knows that sports' products help any player perform at their best. For Ronaldo, Herbalife is the pathway to success.

At just 35-years-old, Cristiano Ronaldo has accomplished a lot as an international sports star. Not only is he a championship-winning magnet, but he has a hand in just about every facet of the fashion industry, including a mens underwear and perfume line. Perhaps thats why the Portuguese football player has an established net worth of approximately $460 million, making him the second richest sports-star in the world.

Not to mention, the mens sports enhancement company Herbalife is a big supporter of Ronaldos career. The sports star has been a long-time ambassador of the brand name since 2013 and will remain so until 2021. While Herbalife has previously described their partnership with Ronaldo as special, the star has even credited the company for playing a major role in his sports career. Herbalife Nutrition understands how critical nutrition is for my performance and I enjoyed working with their scientific team to develop CR7 Drive, Ronaldo said previously, referring to a sports drink helped energize athletes during workouts. Sounds like the CR7 Drive was Ronaldos go-to drink. No wonder he loves his partnership with Herbalife.

RELATED: A Look At Which Current NBA Stars Would Fit Perfectly With Michael Jordan

Of course, the sport-star must have a multitude of favorite Herbalife products in order for him to remain an ambassador for 8 years. The 35-year-old professional athlete recently starred in another campaign video for Herbalife, helping promote his favorite sports enhancement brand. The clip can be found on Herbalifes Instagram page, where Ronaldo is seen making the brands Nutritional Shake Mix, before drinking it down with a satisfied smile. The Portuguese football player is not only drinking their healthy shakes but also sporting their merch, donning a Herbalife t-shirt. Thats a lot of advertisement for one video. The sports star notes that nutrition is the key to his success on the field. By him being the second richest athlete in the world, were pretty sure people will start taking his advice.

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Cristiano Ronaldo Advertises Herbalife As Nutrition To His Success - TheThings

‘Recovered COVID-19 Patients Returning With Long-Term Lung, Heart, Mental Health Issues’ – IndiaSpend

Mumbai: It is quite clear now that the impact of COVID-19 lies way beyond influenza-like conditions, even for the majority who are not much affected by this dreaded disease. It is also evident that this disease affects many more organs beyond the lungs and the respiratory tract including the heart, kidney, brain, and the gastrointestinal tract. What more do we know and how can we be alert about these conditions, particularly since some of that impact can be long-term?

We speak with S. Chatterjee, senior consultant, internal medicine, Apollo Hospital, New Delhi, and Jeenam Shah, consultant chest physician and interventional pulmonologist at Saifee, Wockhardt and Bhatia Hospitals in Mumbai.

Edited excerpts:

Dr Chatterjee, how have you seen the disease play out, particularly in patients who have recovered from COVID, but face other kinds of problems?

SC: There are minor problems, and there are moderate to major problems that we are seeing in patients who have supposedly recovered from COVID and tested negative for COVID (when repeat testing was allowed) around day 14 or 15.

The most common thing that they are facing--the smallest problem--is that they continue to have a low-grade fever for a much longer time than we expected. They would have fever for about four to five weeks, and without any other cause being found. That really troubles the patients and their relatives. That also confuses us, because we also start looking at other causes of fever. Weakness is a feature, which is variable; it is seen in quite a few people. They have gastrointestinal upsets--like loose motions and vomiting continuing even after the active illness is over.

But [one of] the major things that I have seen is the heart being affected. I have seen patients developing myocarditis [inflammation of the heart tissue]. The degree could vary from mild to moderate, and it is the right side of the heart that is getting involved more than the left. Although none of the patients have become very serious with myocarditis, it is a feature we are seeing in follow-up patients.

The other two things that I have seen are people presenting with a postural drop of blood pressure [when blood pressure drops with change of bodily posture] and having giddiness. And at the moment, I am treating a patient who has developed a nervous involvement--what we call as a GB syndrome [Guillain-Barr syndrome]--developed after almost three to four weeks. I do not know whether it is exactly post-COVID, but the patient suffered from COVID a few weeks back and she has [now] come with that [GB syndrome], and we have not found any other cause for it.

Dr Shah, what have you been seeing? Have people come back, and with what?

JS: I have been seeing a lot of lung fibrosis [damage to the lung tissue] in my outpatient department (OPD) practice. When patients who have been on a ventilator or had required very high oxygen levels during their hospital stay come back to the OPD, most of them have lower oxygen than normal. This is because of a condition known as lung fibrosis. So, any damage to the lung leads to fibrosis, and it is an irreversible damage. So many patients are coming to the OPD practice hypoxic, with low oxygen concentration, and they are requiring home oxygen also. So, they are somewhat bedridden, if at all home-bound. That is the most important complication that I have seen. And it happens in quite a few patients.

It is not that the virus goes away, you are cured, and you are happily ever after. You see a lot of lung fibrosis. I currently have at least 20-25 patients who are on oxygen therapy at home. That is a cause for worry.

Apart from this, I am seeing a lot of mental changes. Most patients who have been in the hospital for a month--on the ventilator, or on the BiPAP support--are developing a lot of mental complications. They are very worried to go out, they have a lot of emotional stress. They are not able to eat well, they have lost weight. Their family is also affected because of that. So that emotional thing is also a very important component post this recovery of COVID infection.

Apart from that, as Dr Chatterjee has mentioned, a lot of patients who have developed myocardial infarction [a heart attack], some kind of myocarditis, have some residual heart diseases that are prevalent even after the COVID infection settles down.

These three things are the most important complications that I have seen. Obviously, COVID involves a lot of other organs also--kidney issues, GI issues have been persistent post recovery from the viral illness also.

You talked about lung fibrosis. Does that affect people uniformly? You said in some cases it is quite serious. How serious is it? How does it affect life, or the ability to lead a normal life subsequently, at least at this point?

JS: We are still very early into the disease. We still need to follow up those patients [to find out] how severe it is, and how long they are persisting with these kinds of problems. But whatever [I have seen] initially--post one to two months of discharge--the older the patient and the more extensive the disease, the more is the fibrosis. If the patient has gone on a ventilator, if the patient is very elderly, the fibrosis tends to be very severe. And the extent of the severity is that the patient cannot even walk a few steps, cannot even go to the washroom on their own without panting, without taking support or without requiring oxygen. So, this is a very severe debilitating disorder that happens post recovery of COVID.

But obviously, it does not affect all the people. It affects only people who have severe disease, the elderly people, and patients who have been on the ventilator. Patients who have very mild symptoms and patients who do not have many problems have recovered successfully without leaving any residual damage in the lungs.

Across age groups, for 100 patients that you have treated, how many would you say have recovered completely and how many are now showing residual symptoms, including serious ones?

JS: The data I am sharing are biased, because I am only treating moderate to severe patients in the hospital. Most of the mild patients have been home quarantined.

I would say almost 10% of my patients in the ICU have gone home on oxygen therapy. That is a sizable number of patients in the ICU. But if I talk about mild patients who have recovered in the ward, 99% of them have not required oxygen therapy, and have not developed any complications of lung fibrosis post their discharge.

Dr Chatterjee, what are the numbers you are seeing?

SC: I would agree with Dr Shah, because we both work with a tertiary care centre and we handle the same sort of patients. I actually forgot to mention we are seeing lung fibrosis and hypoxia very frequently in severe patients who are getting discharged, who were on a ventilator, or who require high flow oxygen for recovery. The percentage, as he said, is the same because we are seeing patients in a big hospital.

But only time will tell us, and we will see as to what percentage of patients really recover or really require long-term oxygen therapy, because lung fibrosis is not totally reversible and it can remain irreversible for a long time.

If you look at the kind of patients who have come back, are you seeing, for instance, that people who you thought had recovered completely, and also were maybe healthier, showing some signs of longer term damage?

SC: Obviously, people who have comorbidities and the elderly people are the patients who have suffered major illness. But [we did see this] even the younger patients. Patients, especially male patients, in the 50- to 60-year age group and even above 45, I [would] put them in the high-risk category even if they have a bit of comorbidities, because that is the age when we are losing quite a few people. I really am very upset when I lose a patient who is between 50 and 60 years, because that is the age when you are almost at the top of your career and everything. And we a
re seeing a lot of patients being lost even in this age group.

I would totally agree that people who have comorbidities, people who are elderly have more complications, but anybody and everybody who has gone on to a ventilator and has required several empirical treatment or modalities have had more complications than the people who have been mildly symptomatic. But I have seen people who were asymptomatic or mildly symptomatic when they were diagnosed coming back even one or two weeks later with several neurological problems--numbness, pain, tingling, weakness, lethargy--which I do not think are major problems but are troubling people in the long term.

Are you able to cure this or at least attempt to treat these symptoms?

SC: Quite a few people actually are recovering with time. But as I said, we are treating it only for the last three to four months. So only time would tell us as to how much of these people recover. People with weakness and the GI symptoms or other like giddiness and postural drop and all that are recovering in two to four weeks time. But quite a few people are not recovering also, and only time would tell us as to what their long-term implication is.

Dr Shah, if you were to compare COVID and non-COVID patients who have been treated in the ICU, is there some similarity? Or do COVID patients who have gone into ICU or intubation come out with deeper residual symptoms?

JS: Whatever I have seen in my practice, I would definitely say that COVID patients who have been in the ICU and the ventilator have come out with deeper symptoms--because the amount of lung fibrosis that the COVID infection is leaving behind is much more than the rest of the lung infection that we have been seeing in so many years. We do not know the exact pathophysiology as to why it is happening.

Apart from that, because the patients are in the hospital for at least a month, a lot of muscle wasting, and other GI complications are also leaving behind much more residual symptoms than routinely expected.

You also talked about mental health. All other factors constant, is this higher in patients who have emerged from COVID treatments as compared to non-COVID patients?

JS: Some amount of mental changes do happen in patients who are in the ICU. Another problem in the ICU is that all the people--doctors, nurses, and ward boys--are wearing the same uniform, everyone is just white [personal protective equipment kits]. You cannot see their expressions, you cannot talk to them.

Generally, an ICU is a very friendly atmosphere, we try to talk to the patients, we try to cheer them up. But in a COVID situation, everyone--including doctors and support staff--is very tense. So, there is absolutely no healthy communication with the patients which is possible. The patients have not spoken to their relatives, or to anyone nearby. So the mental changes are much more than you would expect with normal ICU patients.

I have seen even in moderate to mild patients who are treated in the ward or the rooms, they also tend to develop a lot of mental changes that are not routinely expected because there is so much fear related to corona--that once the patients get corona, they think it is doomsday, that they are not going to come out. They wonder what will happen when they go back home, whether the society will accept them, whether they will be able to move out of the house again, whether they will get infected again, whether they will infect their close ones and the elderly in the family. So many mental factors are going on in the patients mind.

SC: As Dr Shah said, mental illness is a major issue we are finding even [in the wards]. I do not go into the ICU that much, because I am an internist. But I see all these mild to moderate cases in the floors, and they are going into depression, anxiety.

Since the last two weeks, in our hospitals, we have psychologists talking to the patient, they telephonically consult because what is also happening is that the relatives are not allowed to visit patients who are mild to moderately sick because they are in a COVID ward. So, they are all alone and that is pushing them into anxiety and depression. When we go for our rounds, [if] we find a patient not doing too well mentally, we make a psychologist speak with them and we have seen the benefits of being proactive about it.

Dr Chatterjee, as you look ahead, knowing all of this, how can we be more careful?

SC: We have to be mentally strong. Even yoga and meditation actually builds up your mentally stability and your physical health. We have to have a healthy lifestyle, exercise, have the right food, have strong mental health, and yoga and meditation and all that does add to overcoming this illness much more. If you are mentally and physically weak, if you have comorbidities, obviously that makes you more prone to all these after-effects of the illness, which are more common.

Dr Shah, how do we as potential patients or citizens be more prepared for what lies beyond COVID?

JS: It is not the end of the game. We are still not done with COVID as of now. We should not lower our guard. We still need to continue the same precautions that we have been taking over the last four odd months. The virus is still looming very large nearby us.

And one thing that we have not realised is that the doctors are gradually going into exhaustion. If you ask about me, after three months of rigorous practice, there are a lot of difficulties for us also. So, it is upon us the citizens now to take utmost care and not overburden our healthcare system because it is also not in a healthy state right now. Even healthcare can crumble any time.

We welcome feedback. Please write to respond@indiaspend.org. We reserve the right to edit responses for language and grammar.

Mumbai: It is quite clear now that the impact of COVID-19 lies way beyond influenza-like conditions, even for the majority who are not much affected by this dreaded disease. It is also evident that this disease affects many more organs beyond the lungs and the respiratory tract including the heart, kidney, brain, and the gastrointestinal tract. What more do we know and how can we be alert about these conditions, particularly since some of that impact can be long-term?

We speak with S. Chatterjee, senior consultant, internal medicine, Apollo Hospital, New Delhi, and Jeenam Shah, consultant chest physician and interventional pulmonologist at Saifee, Wockhardt and Bhatia Hospitals in Mumbai.

Edited excerpts:

Dr Chatterjee, how have you seen the disease play out, particularly in patients who have recovered from COVID, but face other kinds of problems?

SC: There are minor problems, and there are moderate to major problems that we are seeing in patients who have supposedly recovered from COVID and tested negative for COVID (when repeat testing was allowed) around day 14 or 15.

The most common thing that they are facing--the smallest problem--is that they continue to have a low-grade fever for a much longer time than we expected. They would have fever for about four to five weeks, and without any other cause being found. That really troubles the patients and their relatives. That also confuses us, because we also start looking at other causes of fever. Weakness is a feature, which is variable; it is seen in quite a few people. They have gastrointestinal upsets--like loose motions and vomiting continuing even after the active illness is over.

But [one of] the major things that I have seen is the heart being affected. I have seen patients developing myocarditis [inflammation of the heart tissue]. The degree could vary from mild to moderate, and it is the right side of the heart that is getting involved more than the left. Although none of the patients have become very serious with myocarditis, it is a feature we are seeing in follow-up patients.

The other two things that I have seen are people presenting with a postural drop of blood pressure [when blood pressure drops with change of bodily posture] and having giddiness. A
nd at the moment, I am treating a patient who has developed a nervous involvement--what we call as a GB syndrome [Guillain-Barr syndrome]--developed after almost three to four weeks. I do not know whether it is exactly post-COVID, but the patient suffered from COVID a few weeks back and she has [now] come with that [GB syndrome], and we have not found any other cause for it.

Dr Shah, what have you been seeing? Have people come back, and with what?

JS: I have been seeing a lot of lung fibrosis [damage to the lung tissue] in my outpatient department (OPD) practice. When patients who have been on a ventilator or had required very high oxygen levels during their hospital stay come back to the OPD, most of them have lower oxygen than normal. This is because of a condition known as lung fibrosis. So, any damage to the lung leads to fibrosis, and it is an irreversible damage. So many patients are coming to the OPD practice hypoxic, with low oxygen concentration, and they are requiring home oxygen also. So, they are somewhat bedridden, if at all home-bound. That is the most important complication that I have seen. And it happens in quite a few patients.

It is not that the virus goes away, you are cured, and you are happily ever after. You see a lot of lung fibrosis. I currently have at least 20-25 patients who are on oxygen therapy at home. That is a cause for worry.

Apart from this, I am seeing a lot of mental changes. Most patients who have been in the hospital for a month--on the ventilator, or on the BiPAP support--are developing a lot of mental complications. They are very worried to go out, they have a lot of emotional stress. They are not able to eat well, they have lost weight. Their family is also affected because of that. So that emotional thing is also a very important component post this recovery of COVID infection.

Apart from that, as Dr Chatterjee has mentioned, a lot of patients who have developed myocardial infarction [a heart attack], some kind of myocarditis, have some residual heart diseases that are prevalent even after the COVID infection settles down.

These three things are the most important complications that I have seen. Obviously, COVID involves a lot of other organs also--kidney issues, GI issues have been persistent post recovery from the viral illness also.

You talked about lung fibrosis. Does that affect people uniformly? You said in some cases it is quite serious. How serious is it? How does it affect life, or the ability to lead a normal life subsequently, at least at this point?

JS: We are still very early into the disease. We still need to follow up those patients [to find out] how severe it is, and how long they are persisting with these kinds of problems. But whatever [I have seen] initially--post one to two months of discharge--the older the patient and the more extensive the disease, the more is the fibrosis. If the patient has gone on a ventilator, if the patient is very elderly, the fibrosis tends to be very severe. And the extent of the severity is that the patient cannot even walk a few steps, cannot even go to the washroom on their own without panting, without taking support or without requiring oxygen. So, this is a very severe debilitating disorder that happens post recovery of COVID.

But obviously, it does not affect all the people. It affects only people who have severe disease, the elderly people, and patients who have been on the ventilator. Patients who have very mild symptoms and patients who do not have many problems have recovered successfully without leaving any residual damage in the lungs.

Across age groups, for 100 patients that you have treated, how many would you say have recovered completely and how many are now showing residual symptoms, including serious ones?

JS: The data I am sharing are biased, because I am only treating moderate to severe patients in the hospital. Most of the mild patients have been home quarantined.

I would say almost 10% of my patients in the ICU have gone home on oxygen therapy. That is a sizable number of patients in the ICU. But if I talk about mild patients who have recovered in the ward, 99% of them have not required oxygen therapy, and have not developed any complications of lung fibrosis post their discharge.

Dr Chatterjee, what are the numbers you are seeing?

SC: I would agree with Dr Shah, because we both work with a tertiary care centre and we handle the same sort of patients. I actually forgot to mention we are seeing lung fibrosis and hypoxia very frequently in severe patients who are getting discharged, who were on a ventilator, or who require high flow oxygen for recovery. The percentage, as he said, is the same because we are seeing patients in a big hospital.

But only time will tell us, and we will see as to what percentage of patients really recover or really require long-term oxygen therapy, because lung fibrosis is not totally reversible and it can remain irreversible for a long time.

If you look at the kind of patients who have come back, are you seeing, for instance, that people who you thought had recovered completely, and also were maybe healthier, showing some signs of longer term damage?

SC: Obviously, people who have comorbidities and the elderly people are the patients who have suffered major illness. But [we did see this] even the younger patients. Patients, especially male patients, in the 50- to 60-year age group and even above 45, I [would] put them in the high-risk category even if they have a bit of comorbidities, because that is the age when we are losing quite a few people. I really am very upset when I lose a patient who is between 50 and 60 years, because that is the age when you are almost at the top of your career and everything. And we are seeing a lot of patients being lost even in this age group.

I would totally agree that people who have comorbidities, people who are elderly have more complications, but anybody and everybody who has gone on to a ventilator and has required several empirical treatment or modalities have had more complications than the people who have been mildly symptomatic. But I have seen people who were asymptomatic or mildly symptomatic when they were diagnosed coming back even one or two weeks later with several neurological problems--numbness, pain, tingling, weakness, lethargy--which I do not think are major problems but are troubling people in the long term.

Are you able to cure this or at least attempt to treat these symptoms?

SC: Quite a few people actually are recovering with time. But as I said, we are treating it only for the last three to four months. So only time would tell us as to how much of these people recover. People with weakness and the GI symptoms or other like giddiness and postural drop and all that are recovering in two to four weeks time. But quite a few people are not recovering also, and only time would tell us as to what their long-term implication is.

Dr Shah, if you were to compare COVID and non-COVID patients who have been treated in the ICU, is there some similarity? Or do COVID patients who have gone into ICU or intubation come out with deeper residual symptoms?

JS: Whatever I have seen in my practice, I would definitely say that COVID patients who have been in the ICU and the ventilator have come out with deeper symptoms--because the amount of lung fibrosis that the COVID infection is leaving behind is much more than the rest of the lung infection that we have been seeing in so many years. We do not know the exact pathophysiology as to why it is happening.

Apart from that, because the patients are in the hospital for at least a month, a lot of muscle wasting, and other GI complications are also leaving behind much more residual symptoms than routinely expected.

You also talked about mental health. All other factors constant, is this higher in patients who have emerged from COVID treatments as compared to non-COVID patients?

JS: Some amount of mental changes do happen in patients who are in the ICU. Another problem in t
he ICU is that all the people--doctors, nurses, and ward boys--are wearing the same uniform, everyone is just white [personal protective equipment kits]. You cannot see their expressions, you cannot talk to them.

Generally, an ICU is a very friendly atmosphere, we try to talk to the patients, we try to cheer them up. But in a COVID situation, everyone--including doctors and support staff--is very tense. So, there is absolutely no healthy communication with the patients which is possible. The patients have not spoken to their relatives, or to anyone nearby. So the mental changes are much more than you would expect with normal ICU patients.

I have seen even in moderate to mild patients who are treated in the ward or the rooms, they also tend to develop a lot of mental changes that are not routinely expected because there is so much fear related to corona--that once the patients get corona, they think it is doomsday, that they are not going to come out. They wonder what will happen when they go back home, whether the society will accept them, whether they will be able to move out of the house again, whether they will get infected again, whether they will infect their close ones and the elderly in the family. So many mental factors are going on in the patients mind.

SC: As Dr Shah said, mental illness is a major issue we are finding even [in the wards]. I do not go into the ICU that much, because I am an internist. But I see all these mild to moderate cases in the floors, and they are going into depression, anxiety.

Since the last two weeks, in our hospitals, we have psychologists talking to the patient, they telephonically consult because what is also happening is that the relatives are not allowed to visit patients who are mild to moderately sick because they are in a COVID ward. So, they are all alone and that is pushing them into anxiety and depression. When we go for our rounds, [if] we find a patient not doing too well mentally, we make a psychologist speak with them and we have seen the benefits of being proactive about it.

Dr Chatterjee, as you look ahead, knowing all of this, how can we be more careful?

SC: We have to be mentally strong. Even yoga and meditation actually builds up your mentally stability and your physical health. We have to have a healthy lifestyle, exercise, have the right food, have strong mental health, and yoga and meditation and all that does add to overcoming this illness much more. If you are mentally and physically weak, if you have comorbidities, obviously that makes you more prone to all these after-effects of the illness, which are more common.

Dr Shah, how do we as potential patients or citizens be more prepared for what lies beyond COVID?

JS: It is not the end of the game. We are still not done with COVID as of now. We should not lower our guard. We still need to continue the same precautions that we have been taking over the last four odd months. The virus is still looming very large nearby us.

And one thing that we have not realised is that the doctors are gradually going into exhaustion. If you ask about me, after three months of rigorous practice, there are a lot of difficulties for us also. So, it is upon us the citizens now to take utmost care and not overburden our healthcare system because it is also not in a healthy state right now. Even healthcare can crumble any time.

We welcome feedback. Please write to respond@indiaspend.org. We reserve the right to edit responses for language and grammar.

Originally posted here:
'Recovered COVID-19 Patients Returning With Long-Term Lung, Heart, Mental Health Issues' - IndiaSpend