‘I focus on low-cost tech to fight infectious diseases’ – Business Mirror

A lot has been said and written about the Philippine-made test kitthe first in the countryfor the 2019 coronavirus disease (Covid-19).

As soon as it was announced in March that a Covid-19 test kit is being developed and manufactured in the country, all the news media platforms, columns and talk shows have been awash with stories on the subject. Its been the talk of the town.

Interviews with its creatorled by the multi-awarded Dr. Raul V. Desturahave been held left and right, seeking the story behind the diagnostic system that will help stem the spread of the virus in the country, and proud that it was made in the Philippines, plus being cheaper at P1,300 than the imported P8,000.

Actually the kit is already being used now at the Philippine General Hospital (PGH) and other major hospitals around the country that are handling Covid-19 cases after the Food and Drug Administration Philippines(FDA) approved its commercial use on April 3.

The test kit was developed in collaboration with the University of the Philippines-National Institutes of Health (UP-NIH), and funded by the Department of Science and Technology (DOST). It is manufactured by Manila HealthTek that was also supported by the DOST.

It was a just-in-time scenario for the Philippines when it badly needed test kits for Covid-19 cases.

It was a much-awaited result of research and development, which was conducted immediately when the coronavirus pandemic startled the whole world in January 2020. This completely upholds the DOST of the mantra R&D making change happen.

Despite Desturas being busy attending to interviews, they were mainly about his research on the test kit, and rarely about himself.

Who is this scientist behind the Covid-19 test kit?

As a clinician-scientist, I continuously try to narrow down the gap between basic science, medical science, biotechnology and community service by forging strong collaboration among disciplines to reach a focused goal, Destura said as quoted by the NIH UPM web site.

My research bench to community approach is ultimately geared toward developing low-cost technologies for the control of infectious diseases in the Philippines and the generation of new knowledge to find sustainable and equitable solutions to disease of poverty, added Destura, the vice president and chairman of the Division of Medical Sciences of the National Research Council of the Philippines (NRCP).

A Presidential Lingkod Bayan 2019 Awardee, Destura is a known scientist and molecular microbiologist who is also recognized for developing local and less costly diagnostic kits for rapid detection of the most dreaded infectious diseases such as dengue, hepatitis and tuberculosis.

Notable of these is the Biotek-M, a rapid test kit for dengue that is projected to be more affordable among average Filipino families that may not be able to afford the more expensive polymerase chain reaction technology.

This new technology is hoped to advance the diagnostic capability of the hospitals for better management of the dengue disease. Biotek-M is currently being rolled out to three government hospitals.

Actually the Covid-19 test kit was based on the Biotek-M technology.

Desturas versatility is exhibited by the establishment of two world-class molecular biology laboratoriesthe Molecular Biology and Biotechnology Research Laboratory at the UP NIH and the Clinical Molecular Diagnostic Laboratory of the Medical Cityunder his leadership.

He is also a recipient of several prestigious national and international awards for his innovative research and leadership in research and clinical molecular biology.

Among the awards are the Gold Medal from the International Exhibition of Inventions of Geneva (Salon International Des Inventions Geneve), Geneva, Switzerland in April 2018; International Training and Research in Emerging Infectious Diseases Research Fellowship Award from the Center for Global Health Division of Infectious Disease and International Health, University of Virginia.

The Bill and Melinda Gates Travel Scholarship for 2005 Keystone Symposia; Outstanding Young Scientist of the Philippines in 2008; University of the Philippiness Research Productivity Award in 2011; The Outstanding Young Men of the Philippines in 2011; Gawad Agham 2015.

Outstanding Alumni in Microbiology of the University of Santo Tomas; 2015 Outstanding Alumni in Medicine of the De La Salle University; and the prestigious 2015 Dr. Jose Rizal Memorial Award in Research given by the Philippine Medical Association.

At the NRCP, Destura was named the 2015 Dr. Eusebio Y. Garcia awardee. The award is given annually to Filipino scientists in recognition of their outstanding research contributions in the fields of Molecular Biology and Molecular Pathology.

The award was founded by Dr. Eusebio Y. Garcia in 1985 to encourage more researchers to venture into this field and also to recognize the ground breaking researches made by the Filipinos in the said field.

In June 2018, immunization became a hot topic in the country because of the Dengvaxia scare. Amid the controversy, the NRCP made a categorical pronouncement on the importance of vaccines.

The NRCP statement, crafted by Destura, stated that scientific evidence has clearly demonstrated that vaccines have dramatically eradicated small pox and polio and have greatly reduced child mortality in the Philippines and in many parts of the world. The NRCP stands by the government efforts to sustain its immunization programs as we strongly urge the public to pay attention to the knowledge claim of scientists on the beneficial effects of immunization.

On March 7, while in the midst of isolation for his research work on the Covid-19 test kit, NRCP President Dr. Ramon A. Razal consulted Destura when the Department of Health raised Red Code Alert on Covid-19.

Upon Desturas expert advise and with the NRCP Governing Board approval, Razal postponed the NRCPs biggest annual event, the Scientific Conference and 87th General Assembly in Manila on March 9. The conference has an anticipated 1,200 participants from all over the country.

The decision became the Councils contribution to the national efforts to prevent the risk of further local or community transmission of Covid-19.

Destura studied Medicine at the De La Salle University Health Sciences in 1996, and went to pursue training and research fellowship in Infectious Disease at the UP-PGH from years 20012003.

He went to University of Virginia, US, for higher learning and international training in Emerging Infectious Diseases. Maria Elena A. Talingdan, S&T Media Service

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'I focus on low-cost tech to fight infectious diseases' - Business Mirror

Coronavirus in Ireland: What we know so far – The Irish Times

How is Ireland doing in the fight to slow the spread of Covid-19?

After more than two weeks of lockdown with wide ranging restrictions limiting commercial and social life, the battle rages on and there are no definitive signs that a peak has been reached. The country is at a delicate and critical point in its response to the coronavirus outbreak, according to Liz Canavan the assistant general secretary at the Department of the Taoiseach. Many people have fallen ill and too many have died and while there is some optimism that the Republic may not be hit as hard by Covid-19 as Italy, Spain and the UK, it is still too early to say what may happen in the weeks ahead.

What are the numbers?

On Tuesday, April 14th, 41 more people were reported to have died from coronavirus in the Republic taking the total number of fatalities to 406 while the number of known cases reached 11,479. Modelling data used by the National Public Health Emergency Team shows the daily growth rate has fallen from 33 per cent in the early stages of the outbreak to 9 per cent this week.

What is happening in Northern Ireland?

Ten more coronavirus-related deaths were announced in Northern Ireland on Tuesday, bringing the total number of fatalities to 134. On the same day a total of 1,967 cases had been identified in the North.

How is the Republic doing when it comes to testing?

Testing and contact tracing in real time between 24 and 48 hours is needed to fully contain the disease, experts have said. Minister for Health Simon Harris has said the mantra is to test, test, test. There have been widely reported shortages of testing kits and lab supplies and the waiting times for results, according to the Department of Health, was about seven to 10 days. But things have improved.

HSE chief executive Paul Reid said a backlog in testing had been reduced from a high point of about 35,000 people waiting for results to some 11,000. He told a briefing in Dublin on Tuesday that 25 laboratories were now being used to examine Covid-19 tests, including 20 in hospitals, the national lab in UCD, a Department of Agriculture facility and in Germany. Mr Reid said nearly 8,000 tests were completed on Saturday. That backlog will continue to be reduced and will be reduced completely by the end of this week, he said.

How does that compare with elsewhere in the world?

Mr Reid, has said that Ireland is a top-tier country although that claim has been disputed by some. Dr Sean LEstrange, a social scientist in UCD, has conducted a comparative analysis of reported testing figures. It is difficult to support the claim that Irelands testing practice for Covid-19 is in the top tier in the world, he wrote this week. Ireland is not doing badly and it is certainly not amongst the worst in the world by any stretch of the imagination. Yet compared with other similar-sized and resourced states in the European context, its performance is decidedly middling, he wrote.

How important is the testing?

If you have symptoms, it may not matter all that much. If you become sick enough to be hospitalised, you will get a fast-track result but if not, you stay at home and self-isolate until the symptoms lift. The reason testing really matters is that it is a key part of relaxing restrictions. Building a system that can turn around results, and fast, is key, according to chief medical officer Dr Tony Holohan. We need to have a contact-tracing capacity and testing capacity to give us real-time in other words same-day or following-day results, he said.

Speaking of testing, will the Leaving and Junior Certificate exams go ahead?

Last week, Taoiseach Leo Varadkar said the State exams would go ahead by hook or by crook and so they will or at least one set will. It was confirmed on Friday that the Leaving Cert would take place in late July or August. The Junior Cert, meanwhile, is set to be replaced by school-based exams which will run early in the new school year.

The changes mean tens of thousands of students who are due to progress to third level and further education are likely to commence their courses much later than originally planned. Deadlines for students to complete practicals and project work in a number of subjects such as history, geography and home economics will also be extended until late July. Students had been given a deadline of May 15th to complete this work. While the move will bring much-needed clarity to students over contingency plans for the Leaving Cert, it is likely to be a major disappointment for many students who now face an extended summer preparing for the exams.

Movement is still seriously restricted, what powers do garda have to enforce this?

At the beginning of last week, Mr Harris signed regulations granting powers of enforcement to garda. The powers were passed by the Oireachtas in late March but became active only with the Ministers signature. The regulations are based on the guidelines issued by the Government two weeks ago and anyone exercising more than 2km from their home or with people from outside their household will be in breach of the law. Anyone travelling beyond 2km for non-essential reasons will also be in breach. An offence will be committed only if a person refuses a direction from a garda to comply with the regulations. It is not the breaching of regulations that is illegal, but disobeying the gardas instructions once caught.

Will there be many arrests?

Front-line garda have been instructed to use a four-step graduated policing response in the days ahead and should give members of the public every opportunity to comply with the regulations.

Enforcement will be a last resort and only when all other avenues have been exhausted in most cases, an internal Garda document says. Before resorting to arrest, garda must go through the four-step escalation process termed Engage, Explain, Encourage, Enforce. Engage involves asking people their name and address, reason for travel and if they are aware of the restrictions. Garda may arrest anyone who refuses to give their name and address. If required they then move on to the explain stage, which involves highlighting the risks of breaking the rules. They must then encourage those in breach to stay at home to save lives. The final step, enforce, involves using Garda powers to discourage further non-compliance. This should be done only when necessary and proportionate.

How was the bank holiday weekend?

There was a very high level of compliance with restrictions on non-essential travel over the bank holiday weekend, according to Ms Canavan. A major policing operation was put in place over the Easter bank holiday with checkpoints across the country to ensure people complied with public health guidelines, over fears people would travel to holiday homes due to the fine weather.

And were there many arrests?

Garda made seven arrests over the long weekend under the new legislation. An Garda Sochna said these arrests were made when people repeatedly refused to comply with directions to abide by the movement restrictions which prohibit unnecessary travel and exercise further than 2km from the home. In addition there were 144 incidents where garda enforcing the coronavirus restrictions instead made arrests under other, long-standing legislation. These incidents included arrests for public order breaches, assault, road traffic offences and drug offences. The arrests were made at house parties and street gatherings and where garda found people engaged in non-essential travel.

If I got Covid-19 can I get it again?

No one knows for certain what level of immunity those who have had and then recovered from the illness will have. We simply dont know yet what it takes to be effectively protected from this infection, Dawn Bowdish, a professor of pathology and molecular medicine in Ontario told Scientific American this week.

What we do know is that immunity to other coronaviruses, including the common cold, can start declining within weeks of infection.

Within weeks? That doesnt sound good?

No, but studies of Sars-CoV the virus that causes Sars, which shares a lot of the same elements as Covid-19 suggest that immunity peaks at around four months and offers protection for roughly two to three years. That would give time for a vaccine to be developed without those with the Covid-19 antibodies becoming reinfected.

Are more young people dying from the illness than expected?

The early narrative was that Covid-19 was an illness that largely spared young and healthy people but as it has spread across the world, it has shown itself to be more indiscriminate than many health experts initially thought. As it stands in Ireland more than 90 per cent of the victims have been over 65. While older people and those with pre-existing conditions are most at risk, it has occasionally hit young and apparently fit people including healthcare workers exposed to those with the virus. The youngest person to die so far was aged 30, the oldest was 105 years.

Why is that?

Sometimes previously undiagnosed conditions are later revealed and sometimes there are no such explanations.

What are the scientists saying?

There have been many theories circulating in medical and scientific circles. There is a school of thought which suggests that a huge dose may hit people much harder than smaller doses while another school of thought points to genetic susceptibility with some people more vulnerable to the virus than others, irrespective of their age. It is very possible that some of us could have a particular genetic make-up that makes it more likely that we will respond badly to an infection with this coronavirus, virologist Michael Skinner at Imperial College London told the Guardian newspaper this week.

A person with a high viral load has more virus particles than one with a low load, said virologist Alison Sinclair at Sussex university. We do not yet know what impact viral load has on the symptoms of a person infected with Covid-19. Whether there is a link between a high viral load and worse outcomes is going to be important to find out.

What has been happening in nursing homes in Ireland?

The number of coronavirus infection clusters in nursing homes around the country has reached 149, according to the latest detailed figures on coronavirus cases released by State officials. Nursing homes now account for one-third of the clusters of infection across the country. This is incredibly serious not only because of the vulnerability of those in such care settings. It has become clear that Covid-19 has virus loads which are three times what might be found with other respiratory viruses such as flu, including in older patients, who are more contagious than expected.

How significant is that?

It is very significant. These are the highest viral loads for any virus I know, Prof Marc Van Ranst at the Rega Institute for Medical Research in Leuven, Belgium, said this week. He said he was astonished at the number of the germs he saw from patient throat samples in his lab. Especially surprising, he said, was that elderly people harbour prodigious quantities of virus.

Not many elderly [people] are going to transmit the influenza virus to someone else. They get infected, but are not infecting others, said Prof Van Ranst not so for Covid-19. When I look at the viral loads that we find in elderly people, it is mind boggling, he said. That has been for me the big surprise with this virus. This will influence how contagious elderly people can be and perhaps is reflected in the high number of Covid-19 clusters in nursing homes, he added.

What else have we learned in recent days?

The virus is also abundant in the throats of younger patients according to viral counts reported in the science journal Nature. Nine young to middle-aged office workers near Munich, Germany, who showed mild flu-like symptoms, had their nose and throat swabbed daily and spit samples collected for viral counts. We detected Sars-CoV-2 in enormous amounts in the upper respiratory tract, said Prof Clemens Wendtner, who led the research in Germany 1,000 times more than for Sars. This was shocking news.

All nine patients showed a high rate of viral replication and shedding in their throat during their first week of infection. The virus does not need to travel to the lungs to replicate, and is abundant in the throat, making it easy to pass on. It can be spread easily by sneezing or coughing, said Prof Wendtner.

The viral loads that people encounter when someone coughs in their general direction, are so high, said Prof Van Ranst, that it makes transmission likely to happen. Compared to other respiratory viruses, this is remarkable, he added. It also meant it was easier for those with even mild symptoms to contaminate surfaces.

The Nature paper confirms that for the milder form of the disease, it doesnt go as far as the lungs, but stays in the throat, said immunologist Prof Luke ONeill of Trinity College Dublin. It means it is very transmissible just by talking. You dont need to cough, he said. Also, people without symptoms, are very infectious, he added. Sars never infected the throat. Went straight to the lungs. So thats a big difference, he explained.

Are men more likely to die than women?

The short answer is yes. With the worldwide death toll closing in on 130,000 it has become clear that men are much more likely to die from coronavirus than women. Charity Global Health 50/50, which campaigns for gender equality in health, has been tracking the breakdown internationally for deaths from the virus. In every country that publishes the data, significantly more men than women have died.

In Italy, which has the highest number of deaths from the disease, men account for 58 per cent of all hospitalised cases and 72 per cent of all deaths. In Spain, men account for 59 per cent of all hospital admissions, 72 per cent of intensive care unit admissions and 65 per cent of all deaths. In China, where the virus first started, 64 per cent of fatalities have been men.

In the Republic men account for less than half (45 per cent) of all confirmed cases, but 71 per cent of deaths.

Why is that?

Irelands deputy chief medical officer Dr Ronan Glynn said there were a number of hypotheses as to why this phenomenon was happening. It is either biology or behaviour or a mixture of both, he said. In some countries significantly greater proportions of men smoke. The activity of smoking is often associated with touching your face. Royal College of Surgeons in Ireland professor of medicine Sam McConkey believes the reasons may be more general.

Its just speculation, but Im happy to speculate that men in general do not look after themselves, he said. We drink too much and we smoke too much and we do not go to the doctor. Women are much better at getting proper diagnosis and taking the proper tablets.

How long will the restrictions be in place?

As it stands the restrictions on movement and social and commercial life in the country will remain in place until May 5th but even then we are only likely to see a partial lifting of the strict regime and that is contingent on the rate of infections continuing to fall.

What does partial mean?

Senior Government officials have begun to work on plans for a phased exit from the lockdown with the priorities expected to include the reopening of more retail businesses, construction and maybe schools although that might only be for some classes and for a portion of the week only.

When the time comes for restrictions to be eased they will be lifted in reverse order with movement and retail looked at first.

Dr Cillian De Gascun, chairperson of the coronavirus expert advisory group, has warned against complacency about the dangers of Covid-19 because given the opportunity this virus will run rampant and he warned that we are not going to return to a normal state of affairs soon.

What else in being considered to bring the pandemic under control here?

Prof McConkey has said the Government was at a crossroads and was faced with two decisions on treating Covid-19. The first option would to continue efforts to flatten the curve over a period of six to nine months while the second choice is more severe and would see a short, sharp response to try to prevent the spread of the virus entirely in Ireland. This move would require a 32-county approach.

It would be challenging. It would mean restricting travel and quarantining people coming into the country, Prof McConkey said. I feel it has to be a national decision, we would have to get Northern Ireland to go with us on this journey. It would have to be an all-island approach. It needs national discussion and involve all the parties in Northern Ireland. This is the approach being adopted in countries such as South Korea and New Zealand.

Will the virus diminish as the summer approaches and temperatures climb?

That was a hope in the very early days of the crisis. While it is getting warmer, experts are no longer holding out much hope that better weather will kill off coronavirus. The flu virus goes into decline in warmer months, and is spread the same way as Covid-19, by way of small mucus droplets suspended in the air. When conditions are warmer, droplets are more likely to fall to the ground and not cause infection which is one reason flu is seasonal and dominant in winter. The other is because exposure to the cold during winter coincides with immune systems being stressed. There is no indication that any of this applies to Covid-19, Prof Kingston Mills from Trinity College told this publications Science Editor Kevin OSullivan. He said it may prove to be the case but caution had to be applied. He pointed out that Spain is a damn sight warmer, and look at what its going through.

Why are some people so infectious and what are superspreaders?

One of the questions scientists have been asking as the virus continues to spread is if some people are more infectious than others and the answer appears to be yes. There do seem to be superspreaders, a loosely defined term for people who infect a disproportionate number of others, whether as a consequence of genetics, social habits or simply being in the wrong place at the wrong time. There are also people who are infected but unlikely to spread the infection.

Two factors are at play, Martina Morris, emeritus professor of statistics and sociology at the University of Washington told the New York Times this week. There has to be a link between people in order to transmit an infection, she says. But, she adds, a link is necessary but not sufficient. The second factor is how infectious a person is. We almost never have independent data on those two things.

If you are the first person in a crowded room to get infected, and if this is an easily spread disease, you will look like a superspreader, she says. Anyone in that room could have had the same impact. You were just the first in line.

Dr Thomas Frieden, former director of the United States Centers for Disease Control and Prevention said superspreading events may involve people with symptoms that linger but who are not sick enough to stay at home. Or they could involve infected people who shed an unusual amount of virus.

People have been attacking 5G masts?

There was a suspected arson attack on two large telecommunications masts in Co Donegal over the bank holiday weekend. Conspiracy theorists have linked new 5G technology to the cause of the global pandemic. The Government here and governments across the EU have all stressed there is absolutely no link between 5G and Covid-19.

What is happening on the economic front?

The coronavirus pandemic has brought the global economy to its knees and is likely to result in the worst economic downturn since the Great Depression, the International Monetary Fund (IMF) has said. In its latest world economic outlook report, it said it expects the global economy to contract sharply by 3 per cent in 2020 with the euro zone, the epicentre of the pandemic for the past month, experiencing a much sharper 7.5 per cent contraction.

Its outlook for Ireland is slightly better though still grim. It expects the economy to contract by 6.8 per cent this year, less severe than the Central Bank projection for an 8 per cent contraction. The IMF expects the Irish economy to bounce back strongly next year, expanding by 6.3 per cent, against a euro-zone average of 4.7 per cent. However, unemployment could prove trickier to ease. The IMF says the jobless rate in Ireland will rise to an average of 12 per cent in 2020, up from a low of 4.8 per cent in February, and will stay elevated at almost 8 per cent in 2021.

What are the unemployment figures in Ireland?

There are 533,000 people registered for the 350 weekly Covid-19 unemployment benefit payment which was introduced in the wake of huge job losses. The take up of a temporary wage subsidy scheme for businesses was continuing to grow, and in total 199 million has been paid out under the scheme to date.

What is being done to aid European economies?

A 500 billion deal was reached between EU finance ministers last week. It has several elements. There is the employment guarantee scheme recently invented by the European Commission. If member states put up 25 per cent collateral, they can get a slice of loans raised by the commission on the market. This would be used to subsidise companies to keep employees on the books. The scheme would be worth a maximum of 100 billion.

There are also loans from the European Investment Bank to support companies: 25 billion of extra guarantees, so it can step up lending by 200 billion.

But the biggest chunk is from the EUs bailout fund, the European Stability Mechanism, which was created to dig out states during the euro zone debt crisis. States can borrow up to 2 per cent of their GDP, with a total of 240 billion available. Usually, taking loans from the ESM comes with the requirement to balance the books known as reforms by supporters, austerity by critics.

This time, borrowing will come without these strict conditions as long as the money is solely for responding to the pandemic and relates directly or indirectly to health spending.

What else is happening?

The European Commission says the new deal should be seen in the context of various other measures, particularly the decision by the European Central Bank to throw off prior restraints to print money, by buying government bonds to keep EU countries liquid. Finance ministers and the commission have also agreed to relax the usual budget rules to give states free rein to spend and support companies, and freed up existing unused funds from the EU budget to be used to respond to the crisis.

What is the Irish Government saying about the deal?

Minister for Finance Paschal Donohoe has said the Government may need limited access to the new European Union Covid-19 rescue package to help fund the wage subsidy scheme and support companies in difficulty.

Mr Donohoe has expressed confidence that the country can create a new economy and create new services to recover and move forward, but he cautioned, we have a journey ahead of us.

The new welfare supports will be monitored and may need to be strengthened to aid the recovery as at least 200,000 workers access the wage subsidy scheme. The Minister said it was possible that Ireland would need to access funds from the European Investment Bank to help fund companies and will consider whether to access the programme to help fund wage subsidy schemes. It is hoped that Ireland will not need to use the fund from the European Stability Mechanism, he added.

What are other people saying?

Alan Ahearne, the professor of economics at NUI Galway said the rescue package was a positive outcome, but warned that the figure needed was likely to increase. Prof Aherne said that as it stands Ireland will not need to borrow from the European Stability Mechanisms new low-cost loan fund, as the European Central Bank keeps borrowing costs close to zero. He said he was cautiously optimistic the recovery would be much, much quicker than a usual recession given the welfare supports that have been put in place.

Is China over the crisis now?

No one thinks the crisis is over in any country in the world. However, the country where the first cases of the virus were recorded more than 100 days ago has made substantial progress in recent days. It reported zero new coronavirus deaths on one day last week for the first time since it started publishing daily figures in January. That is a milestone that offers grounds for some relief as the country works to stave off a second wave and struggles with ongoing outbreaks in Wuhan. The National Health Commission reported 32 new cases across China on Tuesday, all of them imported infections, bringing the number of cases involving overseas travellers to 983.

Are EU countries about to ease restrictions?

Some EU countries are easing some restrictions or at least they will in the days ahead. In Denmark, there is what has been described as a cautious reopening, starting with daycare and primary schools opening. The Danish prime minister Mette Frederiksen has described the process as a bit like walking the tightrope. In Austria, small shops, hardware and gardening stores have been allowed to reopen under certain conditions with all retailers likely to follow from May 1st. Spain and Italy have also started to partially lift restrictions.

The European Commission has urged all EU states to co-ordinate as they begin to ease lockdown measures, warning that failure to do so could result in new spikes of the epidemic.

In a set of recommendations to be adopted this week, the commission said: It is time to develop a well co-ordinated EU exit strategy. The exit strategy should be co-ordinated between the member states, to avoid negative spillover effects.

And when will it all end allowing normality to be restored?

No one can answer that question with any confidence but it is unlikely that all restrictions will be lifted for several months and the aftershocks, in terms of public health, economic life and social activities will be felt for a lot longer than that.

While Mr Harris has raised the prospect of easing some restrictions, he warned: There isnt going to be a magic point at the start of May where life as we knew it before the coronavirus can resume. I think, being truthful, social distancing is going to remain a very big part of life not just in Ireland but the world over until we get to a vaccine or effective treatment for the coronavirus.

He said the key indicators to watch in the coming weeks would be the rate of growth of the virus, the average number of people in intensive care units and the reproductive rate of the virus, which measures how many people each infected person is likely to pass the virus on to.

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Coronavirus in Ireland: What we know so far - The Irish Times

Hitting the Reset Button on Antibiotics – CTech

Most antibiotic drugs approved in the past decade were similar to one another because they were all developed based on human intuition, according to Regina Barzilay, an Israeli researcher who, together with bioengineer James Collins, headed an MIT team that recently discovered a new, hyper-efficient antibiotic molecule using artificial intelligence.

Barzilays teams discovery, first published in the January edition of peer-reviewed scientific journal Cell, marks the first time in over three decades when a completely new antibiotic molecule was discovered. Called Halicin, the molecule was able to kill two of the most dangerous and durable bacteriasAcinetobacter baumannii and a bacteria from the enterobacteriaceae family. Unlike with other antibiotics, the bacteria failed to develop resistance to Halicin even after 30 consecutive days of treatment.

At the midst of what international health organisations have dubbed the post antibiotic era in which humanity is expected to fight bacteria that has become resilient to conventional treatment, MITs new discovery is nothing short of a revolution. Therefore, it may seem surprising that Barzilay, the leading scientist in the project is not a chemist, a biologist or a medical doctor, but is in fact a computer scientist. Her team focused its efforts on using computers to beat the limitations of human intuition and discover an entirely different drug, the type of which bacteria did not have a chance to familiarize themselves with yet.

According to Barzilay, what the team did was gather a vast range of molecules and test the effect each of them had on delaying the growth of pathogens. The methodology we developed allowed the AI to process the connection between the chemical response and the delay in activity, so that it could predict the effect of new molecules it is exposed to, she said. The system developed by her team scans through a multitude of existing research on known chemical compounds in search of molecules with a potential to function as new antibiotics.

Since 1987, every new antibiotic drug was based on already discovered families of molecular structures that have been used extensively. This becomes a problem as bacteria evolves quickly, developing ever growing resilience against these structures. Since the discovery of penicillin, the first antibiotic compound, early in the previous century, more and more bacteria and viruses have developed resilience and the result is extremely hard to fight superbugs.

The often cited 2016 ONeill report, commissioned by the British government and soon adopted by the United Nations, estimated that, barring a significant leap in addressing antimicrobial resistance, by 2050, 10 million people will die from superbugs every year, costing global economy an accumulated $100 trillion in terms of lost global production. In November, the U.S. Centers for Disease Control and Prevention (CDC) announced the the post antibiotic era has arrived.

As if this werent bad enough, in todays pharmaceutical industry, it is not financially viable to develop new antibiotics. Developing a drug, passing it through regulatory processes, and marketing it, takes an average of 10 years and $1 billion. Despite the public health benefit of introducing new drugs, hospitals and health maintenance organizations (HMOs) are wary to use new and expensive antibiotics, given the readily available cheap options and only do so as a last resort, for short periods of time. This means developing remedies for chronic medical conditions are simply more profitable and this is what both the human and fiscal capital of the industry are focused on.

To exemplify how broken the pharmaceutical market is, one needs to look no further than San Francisco-headquartered late-stage biopharmaceutical company Achaogen Inc. In April 2019, just several months after gaining regulatory approval for a new antibiotic drug it developed, Achaogen, founded in 2002, filed for bankruptcy. Instead of helping the company thrive, the approval brought Achaogens stock down and its sales amounted to a mere $1 million, negligible compared to the required investment.

Shortly thereafter, in January 2020, Melinta Therapeutics Inc. also went bankrupt, after failing to monetize on four drugs. These two boutique companies joined five big pharmaceutical companies that have shut down all of their antibiotic research between 2017 and 2018, bringing the World Health Organization (WHO) to issue a statement earlier this year warning that declining private investment and lack of innovation in the development of new antibiotics are undermining efforts to combat drug-resistant infections. The vast majority of the 60 products currently in development, WHO wrote, bring little benefit over existing treatments and very few target the most critical resistant bacteria.

Barzilays team is attempting to bridge this gap between the needs of the general population and the financial needs of commercial companies. The coronavirus crisis shows how desperately we need innovative solutions, Barzilay said. We have to be quick in developing a treatment and one way to do that is to look at existing drugs or a combination of such, she said.

The team used 2,335 different compounds to teach its AI system to make predictions. Each compound was tested on different bacteria to examine the reaction. Once it studied existing drugs, the computer went on to scan massive new databases of moleculesincluding a wide range of drugs and synthetic and natural materialsto detect any compound that could slow down the growth of Escherichia coli (E. Coli). Since only a small portion of the databases the system studied was of antibiotic compounds, the AI system did not develop any prejudice or bias as to how an antibiotic molecule looks like. All it did was scan for molecules that had non-traditional operating mechanisms that allow them to fight infections that have developed resilience to many existing drugs.

Among the molecules it scanned, the system identified 120 promising molecules. Barzilay and the rest of the team then manually filtered out any molecule that resembled existing antibiotics or was known to be poisonous, leaving them with 23 molecules to test. One of the molecules was Halicin, which stood out because its operating mechanismoverlooked by chemists up to this point targeted the bacterias metabolism.

Barzilay, 50, was born in Chisinau, Moldova and immigrated to Israel with her parents at the age of 20. She studied computer science at

Ben- Gurion University of the Negev (BGU) and moved to New York in

1998 for a PhD at Columbia University. She then moved on to a post doctoral fellowship at Cornell University, finally landing in 2003 at MIT, where she is a professor in the computer science department.

Over the years, Barzilay focused on research related to natural language processing, until, in 2016, she was offered to join a research by the chemical engineering department of the U.S. Defense Advanced Research Projects Agency (DARPA). Barzilay said she was curious to get into this field and spent the first two years learning about the most effective ways to design molecules without even thinking about the pharmaceutical industry, that was not using AI for chemical discovery.

Over the years, some pharma companies managed to harness AI tools developed at MIT for various discoveries, but this was not enough, Barzilay said. My problem was that I was not privy to the whole process, she explained. We would give them the tool, the companies would use it, but I did not know what happened with it. That is why she searched for an in-house collaboration in the university that would bring it full circle. This is how the connection with Collins, who is a pioneer in synthetic biology, was made, resulting in the discovery of Halicin.

Machine learning can completely transform the field of chemical discovery, Barzilay said. The current pandemic illustrates how crucial finding the right medicine in time is and it is hard to believe that coronavirus will be the last pandemic, so we have to create mechanisms for designing new molecules on demand, she said.

Over the past month, as almost everyone was confined to their homes and MITs facilities stood empty, Barzilay and Collins team has been hard at work to discover a cure for Covid-19. One of the reasons we were able to conduct the antibiotic experiment so easily was because we had someone in-house that could test different compounds on human cells to see which of them get infected and which do not, Barzilay said. The problem with Covid-19, she said, was that the scans could not be done at MIT as safely handling the virus required special highly secure quarantine facilities and that there wasnt enough accessible data to train the system.

In the last week, however, fragments of information were released by various sources, Barzilay said. Her team combined these fragments with what is known of the 50 drugs that are currently being tested for

Covid-19 and of SARS (Severe acute respiratory syndrome), another of Covid-19s family of viruses to surface in 2004. We developed several methodologies to combine these different groups of information and created a model that is searching for a molecule that has the potential to fight the virus, Barzilay said.

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Hitting the Reset Button on Antibiotics - CTech

Nanotechnology, the Noble Prize winning tech, can it offer something for the Global War against – Elemental

Its not an Avengers Movie Indeed, but the global threat lies on head of whole humanity and Nano tech, is indeed not a science fiction . But before going further deep . lets see what nano-tech is.

Nanotechnology is science, engineering, and technology conducted at the nano scale, which is about 1 to 100 nano meters.

Nano science and nanotechnology are the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering.

The rapidly increasing death tolls of COVID-19 have been a wake-up call for global health. Many researchers have recently turned their focus to this growing threat and a global effort is underway to halt its spread. Currently, there is no specific antiviral treatment available for COVID-19, but a wide range of pharmaceutical agents are being investigated. Meanwhile, among various fields of science and technology, nanotechnology has great potential to be of enormous help in the prevention, diagnosis, and treatment of COVID-19.

At the prevention stage, nano fiber-based facial respirators, along with nanotechnology-enabled highly effective antimicrobial and antiviral disinfectants, have been the first personal protective means that can prevent the spread of the virus; furthermore, extensive research is underway to develop a vaccine for COVID-19 based on different nano materials. In diagnostics, nanotechnology has shown considerable promise in designing sensors for developing quick-response COVID-19 tests. Last but not least, at the treatment phase, nano medicines have been at the center of many researchers attention, some of which are currently being studied in clinical trials. Hence, nano technologists are carrying out their social responsibility to tackle the ongoing global health emergency.

Currently the most widely used chemical disinfection protocols, halogenated disinfection or solvent/detergent strategies, suffer from a variety of limitations for suppression of environmental virus, such as the production of toxic by products as well as the low disinfect efficiency.Within this context, it is in urgent need to develop a novel strategy to guard against the environmental virus with high efficiency,low cost and minimized contamination.We are especially intrigued by the naturally occurring minerals that possess unique structure, facilitate large-scale production and affect the biological responses of viruses.

As known, nature derived graphene oxide (GO) nano materials is a promising chemical platform for various biomedical applications including protein adsorption,bacterial disinfection,bio reduction,and biosensors.It is worthy of note that GO based materials exhibits a physical toxicity associated with the interaction with cells or tissues. For instances, GO can destruct bacterial membranes by direct inorganic-bio molecule interactions;the attached proteins on GO always result in altering intrinsic structures and denature effects. Moreover, the interplay between GO and microbes have been demonstrated, attributing to the bio reduction of the oxygen-containing functionalities via bacterial respiration.Considering the versatile GO-bio-molecule interactions, we postulate that GO materials could potentially serve as a novel and promising candidate for virus prevention.

Graphene or GO particles can actually be used as the virus detectors or as the virus sensors since,The large surface area and good electrical conductivity of graphene allow it to act as an electron wire between the redox centers of an enzyme or protein and an electrodes surface, which make it a very excellent material for the design of electrochemical biosensors. Graphene promotes the different rapid electron transfers that facilitate accurate and selective detection of cytochrome-c, -nicotinamide adenine dinucleotide, haemoglobin, biomolecules such as glucose, cholesterol, ascorbic acid, uric acid, dopamine and hydrogen peroxide.

Graphene can be used to detect the protein shell found in the coronaviruses, which could be really faster and feasible approach in diagnoses of the patients and to reduce the spread .

The world is at war indeed and if we dont work together with all out potential then this pandemic could actually be the sign of The Great Filter.

Nanotechnology has recently come out from labs as experiments to products as an application and as the research continues the further we will know about its properties.

A very Big Thanks and Shout out to all the Medical Staffs and people who are putting their lives at risks to fight this WAR. You guys are the Real AVENGERS!Stay at home , Stay Safe Everyone

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Nanotechnology, the Noble Prize winning tech, can it offer something for the Global War against - Elemental

Global Nanotechnology in Cancer Treatment Market 2020 Industry Analysis, Opportunities, Segmentation & Forecast To 2025 – MENAFN.COM

(MENAFN - iCrowdNewsWire) Apr 16, 2020

Nanotechnology in Cancer Treatment Market 2020

New Study Reports "Nanotechnology in Cancer Treatment Market 2020 Global Market Analysis, Opportunities, Challenges, Strategies and Forecasts 2025" has been Added on WiseGuyReports.

Report Summary:

The purpose of the report is to provide a comprehensive and detailed analysis for the industry Nanotechnology in Cancer Treatment . The report takes 2020 as the base year and considers a wide range of factors affecting the industry to provide a forecast still the year 2026. The information provided by the report can be used by industry and market analysts as well as by people who have an interest in the industry. The data used in the report is reliable and accurate. Primary and secondary research has been conducted to collect the data. The data in the report has been analysed using a wide range of mathematical and statistical metrics so as to provide the users of the report with quantifiable numbers that can be used to compare the performance of the industry with others of the same type. Methods like Price Trend Analysis. SWOT, Porters 5 Forces have been made use to prepare the report and give a reliable analysis of the industry.

This report presents a comprehensive overview, market shares, and growth opportunities of Nanotechnology in Cancer Treatment market by type, application, key manufacturers and key regions and countries.

The report also presents the market competition landscape and a corresponding detailed analysis of the major vendor/manufacturers in the market. The key manufacturers covered in this report: Breakdown data in in Chapter 3. Abbott LaboratoriesCelgene CorporationCombimatrix CorporationSigma-Tau Pharmaceuticals Inc.Johnson & JohnsonGE HealthcareNanosphere Inc.Mallinckrodt PlcPfizer, Inc.Merck & Company Inc.

In addition, this report discusses the key drivers influencing market growth, opportunities, the challenges and the risks faced by key manufacturers and the market as a whole. It also analyzes key emerging trends and their impact on present and future development.

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This study considers the Nanotechnology in Cancer Treatment value generated from the sales of the following segments:

Segmentation by type: breakdown data from 2015 to 2020 in Section 2.3; and forecast to 2025 in section 10.7. NanoparticlesNanorodsNanofibersGrapheneMetal-Organic FrameworksNanobiosensorsNanofluidic DevicesNanotools

Segmentation by application: breakdown data from 2015 to 2020, in Section 2.4; and forecast to 2025 in section 10.8. Cancer DetectionImagingDrug DeliveryRadiotherapyImmunotherapyPhototherapy

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If you have any special requirements, please let us know and we will offer you the report as you want.

Segmental Analysis: -

The industry Nanotechnology in Cancer Treatment is segmented on the basis of the applications, end-users as well as the type of products and services it provides. The report therefore studies the industry on the basis of these segments. The report provides detailed data related to the applications that drive the growth of the industry. The report also discusses the products and services and their end-users who make a significant contribution to the revenue of the industry Nanotechnology in Cancer Treatment. New product innovations by the industry are also talked about in the report.

Major Key Points from Table of Content:

1 Scope of the Report 1.1 Market Introduction1.2 Research Objectives1.3 Years Considered1.4 Market Research Methodology1.5 Economic Indicators1.6 Currency Considered

11 Key Players Analysis11.1 Abbott Laboratories 11.1.1 Company Details11.1.2 Nanotechnology in Cancer Treatment Product Offered11.1.3 Abbott Laboratories Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.1.4 Main Business Overview11.1.5 Abbott Laboratories News 11.2 Celgene Corporation 11.2.1 Company Details11.2.2 Nanotechnology in Cancer Treatment Product Offered11.2.3 Celgene Corporation Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.2.4 Main Business Overview11.2.5 Celgene Corporation News 11.3 Combimatrix Corporation 11.3.1 Company Details11.3.2 Nanotechnology in Cancer Treatment Product Offered11.3.3 Combimatrix Corporation Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.3.4 Main Business Overview11.3.5 Combimatrix Corporation News 11.4 Sigma-Tau Pharmaceuticals Inc. 11.4.1 Company Details11.4.2 Nanotechnology in Cancer Treatment Product Offered11.4.3 Sigma-Tau Pharmaceuticals Inc. Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.4.4 Main Business Overview11.4.5 Sigma-Tau Pharmaceuticals Inc. News 11.5 Johnson & Johnson 11.5.1 Company Details11.5.2 Nanotechnology in Cancer Treatment Product Offered11.5.3 Johnson & Johnson Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.5.4 Main Business Overview11.5.5 Johnson & Johnson News 11.6 GE Healthcare 11.6.1 Company Details11.6.2 Nanotechnology in Cancer Treatment Product Offered11.6.3 GE Healthcare Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.6.4 Main Business Overview11.6.5 GE Healthcare News 11.7 Nanosphere Inc. 11.7.1 Company Details11.7.2 Nanotechnology in Cancer Treatment Product Offered11.7.3 Nanosphere Inc. Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.7.4 Main Business Overview11.7.5 Nanosphere Inc. News 11.8 Mallinckrodt Plc 11.8.1 Company Details11.8.2 Nanotechnology in Cancer Treatment Product Offered11.8.3 Mallinckrodt Plc Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.8.4 Main Business Overview11.8.5 Mallinckrodt Plc News 11.9 Pfizer, Inc. 11.9.1 Company Details11.9.2 Nanotechnology in Cancer Treatment Product Offered11.9.3 Pfizer, Inc. Nanotechnology in Cancer Treatment Revenue, Gross Margin and Market Share (2018-2020)11.9.4 Main Business Overview11.9.5 Pfizer, Inc. News 11.10 Merck & Company Inc.

Continued..

NOTE : Our team is studying Covid-19 and its impact on various industry verticals and wherever required we will be considering Covid-19 footprints for a better analysis of markets and industries. Cordially get in touch for more details.

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Global Nanotechnology in Cancer Treatment Market 2020 Industry Analysis, Opportunities, Segmentation & Forecast To 2025 - MENAFN.COM

Nanotechnology in Environmental Applications Market Production, Revenue and Market Share by Manufacturers, Key Regions and Type – Jewish Life News

Nanotechnology in Environmental Applications:

This report studies the Nanotechnology in Environmental Applications Market with many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the complete Nanotechnology in Environmental Applications Market analysis segmented by companies, region, type and applications in the report.

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Nanotechnology in Environmental Applications Market continues to evolve and expand in terms of the number of companies, products, and applications that illustrates the growth perspectives. The report also covers the list of Product range and Applications with SWOT analysis, CAGR value, further adding the essential business analytics. Nanotechnology in Environmental Applications Market research analysis identifies the latest trends and primary factors responsible for market growth enabling the Organizations to flourish with much exposure to the markets.

Market Segment by Regions, regional analysis covers

Research objectives:

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The Nanotechnology in Environmental Applications Market research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

Table of Contents: Nanotechnology in Environmental Applications Market

Key questions answered in this report

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Reports and Markets is not just another company in this domain but is a part of a veteran group called Algoro Research Consultants Pvt. Ltd. It offers premium progressive statistical surveying, market research reports, analysis & forecast data for a wide range of sectors both for the government and private agencies all across the world. The database of the company is updated on a daily basis. Our database contains a variety of industry verticals that include: Food Beverage, Automotive, Chemicals and Energy, IT & Nanotechnology in Environmental Applications, Consumer, Healthcare, and many more. Each and every report goes through the appropriate research methodology, Checked from the professionals and analysts.

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Nanotechnology in Environmental Applications Market Production, Revenue and Market Share by Manufacturers, Key Regions and Type - Jewish Life News

Nanotechnology and Fuel Cell Market Drivers, Restraints and Opportunities- 2020 To 2023 – Science In Me

Nanotechnology and Fuel Cell Marketresearch will help you to decide how the market will evolve, to make confident decisions to capture new opportunities. Nanotechnology and Fuel Cell Market Report also describes the supply and demand situation, market landscape, and competitive scenario. The report covers the growth scenarios over the coming decades & discussion of the key vendors.

The research report focuses on target groups of customers to help players to effectively market their products and achieve strong sales in the Nanotechnology and Fuel Cell market. The research report has analyzed all current trends and previous status of business under the supervision of business specialists.

Based on Classification, each type is studied as Sales, Market Share (%), Revenue (Million USD), Price, Gross Margin and more similar information. The report can help to realize the market and strategize for business expansion accordingly. In the strategy analysis, it gives insights from marketing channel and market positioning to potential growth strategies, providing in-depth analysis for new entrants or exists competitors in the Nanotechnology and Fuel Cell industry.

The Nanotechnology and Fuel Cell Market report wraps:

There are 13 Chapters to thoroughly display the Nanotechnology and Fuel Cell market. This report included the analysis of market overview, market characteristics, industry chain, competition landscape, historical and future data by types, applications and regions.

In the end, The objective of the market research report is the current status of the market and in accordance classifies it into a few objects. The report takes into consideration the first market players in every area from over the globe.

Note In order to provide more accurate market forecast, all our reports will be updated before delivery by considering the impact of COVID-19.

Qurate Business Intelligence delivers unique Market research solutions to its customers and help them to get equipped with refined information and Market insights derived from reports. We are committed to providing best business services and easy processes to get the same. Qurate Business Intelligence considers themselves as strategic partners of their customers and always shows the keen level of interest to deliver quality.

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Nanotechnology and Fuel Cell Market Drivers, Restraints and Opportunities- 2020 To 2023 - Science In Me

LipoCoat snaps up 1.5 million to market its infection control tech – EU-Startups

Dutch scaleup LipoCoat, a biotech spin-off from the renowned nanotechnology institute MESA+ of the University of Twente, has received additional funding of 1.5 million euros from several investors. These fresh funds will enable LipoCoat to bring its innovations in infection control to market faster and better address the current concerns surrounding the COVID-19 pandemic.

LipoCoat, founded in 2016, specializes in developing infection control solutions for the healthcare industry, in particular for medical devices. Its unique bio-inspired and non-toxic coatings prevent adhesion of bacteria and viruses, overall reducing infection risks. Now a team of 14 people, the scaleup is currently running seven research projects, partnering with multinationals that want to increase the safety of their medical devices.

Currently, launching innovations for medical devices and the healthcare industry is time-consuming. That is why LipoCoat focuses on product-market combinations with a fast rollout, such as the contact lens market, said Jasper van Weerd, Founder and CEO of LipoCoat. The first contact lenses with the LipoCoat coating are in the medical approval process, with the product expected to be launched in autumn 2020. In a few years time, LipoCoat expects the first coated catheters to enter the market. Catheter infections worldwide cause significant suffering and patient discomfort. In addition, such infections increase healthcare costs by billions of euros annually worldwide.

LipoCoat is also developing a coating that can be used for the screening and testing of new medicines that involve cell culture systems. These systems are usually sensitive to pollution. When cell culture systems are contaminated, the testing of new medicines becomes unreliable. The LipoCoat coating increases the efficiency of drug screening and testing, resulting in cost reduction and better results. The solution will become available as a kit and is expected to be launched in the summer of 2020.

The new funds raised by the startup were provided by Dutch informal investors, the High Tech Fund from Enschede and Innovation Fund Rabobank, and will be used to bring the scaleups innovations in infection control to market faster. The High Tech Fund has committed 600K for equipment and supplies in LipoCoats new lab facility. In late April 2020, LipoCoat will open its own dedicated lab facility at Kennispark Twente, the innovation campus of the University of Twente.

To make the leap to further growth, a Series B funding round of 5 million is planned for mid-2021. With this investment round, the company wants to build its revenue streams, increase its development and production capacity, and expand its international footprint by gaining access to US and Asian markets.

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LipoCoat snaps up 1.5 million to market its infection control tech - EU-Startups

The Dangers of Decoupling: Earth System Crisis and the ‘Fourth Industrial Revolution’ – Global Policy Journal

The question of whether global capitalism can resolve the earth system crisis rests on the (im)possibility of absolute decoupling: whether or not economic growth can continue indefinitely as total environmental impacts shrink. Ecomodernists and other technooptimists argue for the feasibility of absolute decoupling, whereas degrowth advocates show that it is likely to be neither feasible in principle nor in the timeframe needed to ward off ecological tipping points. While primarily supporting the degrowth perspective, I will suggest that the ecomodernists have a wildcard in their pocket that hasnt been systematically addressed by degrowth advocates. This is the Fourth Industrial Revolution, which refers to convergent innovations in biotechnology, nanotechnology, artificial intelligence, 3D printing, and other developments. However, I will argue that while these innovationsmayenable some degree of absolute decoupling, they will also intensify emerging risks in the domains of biosecurity, cybersecurity, and state securitization. Overall, these technologies will not only place unprecedented destructive power in the hands of nonstate actors but will also empower and incentivize states to create a global security regime with unprecedented surveillance and force mobilization capacities. This reinforces the conclusion that mainstream environmental policies based on decoupling should be reconsidered and supplanted by alternative policy trajectories based on materialenergetic degrowth, redistribution, and technological deceleration.

Policy Implications

Image: Pixabay via Pexels

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The Dangers of Decoupling: Earth System Crisis and the 'Fourth Industrial Revolution' - Global Policy Journal

Nanomechanical Testing Market to Witness Comprehensive Growth by 2028 – Science In Me

Nanomechanical Testing Market Introduction

Nanomechanical testing involves the technique and equipment used to study the fundamental mechanical properties of materials at the level of nanometers. The testing of mechanical properties of nanomaterials forms the scientific foundation for nanotechnology.

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Nanomechanical testing equipment and methods are used to test the effectiveness of nanomaterials for specific applications by thoroughly analyzing the thermal, elastic, and kinetic properties of nanostructures. The testing equipment and techniques is finding usage in the production of nanopowders, nanotubes, carbon nanotubes, nanocoatings, nanocomposite materials, nanorods, nanowires, and other nanostructures. Nanotechnology-based components are finding widespread adoption in an assortment of industries and the demand for these elements is estimated to remain robust in the foreseeable future. A surge in the demand for nanotechnology-based components in an array of industrial applications is expected to fuel nanomechanical testing market growth with the market generating revenues of approximately US$ 280 million in 2018.

Nanomechanical Testing Market Dynamics

High-Temperature Nanomaterial Testing to Remain a Vital Revenue Pocket

With nanotechnology being a relatively newer field of interest in an array of industries, it is necessary to analyze the mechanical properties of nanomaterials under harsh environmental conditions to ensure they impart effective performance in real-time conditions. Testing of nanomaterials under high temperature is gradually gaining traction, stemming from the burgeoning demand for nanocoatings in high-temperature applications such as aerospace engine component production, nuclear reactor cladding, and high-speed machining. Effective analysis of the mechanical properties of nanomaterials under extreme temperature conditions is necessary to ascertain the performance of these advanced materials. Nanomechanical testing of materials at high temperature requires the use of precise, accurate, and careful designing of equipment than the ones used for analysis of these materials at room temperature. The burgeoning demand for the development of high-precision nanomechanical testing equipment and techniques are estimated to contribute significantly to the market growth. Nanoindentation is gradually emerging as a popular nanomechanical testing procedure for effectively analyzing the mechanical properties of nanomaterials under high temperatures.

Breakthroughs in MEMS Development to Uphold Nanomechanical Testing Market Growth

MEMS or micro-electro-mechanical systems are miniaturized versions of mechanical or electro-mechanical components which can vary in size from one micron to several millimeters. These are nothing but miniature sensors, actuators, and microelectronics. Continuous innovation and research and development in MEMS production are aiding manufacturers to effectively use the devices in analyzing the mechanical and electrical properties of nanostructures.

Additionally, nanomechanical testing is also used for the production of effective MEMS designs and devices. Organizations are increasingly using nanoindentation in combination with other nanomechanical testing techniques for testing the fracture and stiffness resistance of MEMS structures. Further, nanomechanical testing is finding widespread usage in the assessment and optimization of MEMS device tribology which is central to measuring the performance, reliability, and efficiency of these devices. MEMS is expected to find extensive adoption in biotechnology, medicinal, communication, and sensing applications which, in turn, is likely to bolster nanomechanical testing market growth.

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Intensifying R&D in Structure Modification: Key Determinant of Market Success

Controlling the structure of conventional materials while their modification to produce relevant and desired performance results is gradually gaining traction in an assortment of industries such as construction, semiconductor manufacturing, and electronics. With increasing microstructure complexity and growing demand for thinner, flexible, and smaller nanomaterials, the requirement for efficient classification techniques to measure the impact of changes on the overall mechanical properties of the structure is on the rise. Accelerating development and investments in material technology is expected to bolster nanomechanical testing market proliferation.

Environmental Safety and Human Health Concerns Surrounding Nanomaterials to Stifle Market Growth

A rapid rise in the uptake of nanomaterial in an assortment of industries is causing an increasing concentration of nanomaterials to enter the environment and even the human body. Increasing concentration of nanomaterial in the environment has been found out to have an adverse impact on small fish, algae, bacteria, and other crustaceans, a factor which could potentially create an imbalance in the ecosystem. The lack of effective techniques for measuring and defining the adverse impact of nanomaterials on human health and environment is further raising concerns about the growing use of the material in industries. These factors are expected to dampen nanomechanical testing market growth as administrations around the world are increasingly contemplating to implement stringent guidelines on the manufacturing and disposing of nanostructures.

Nanomechanical Testing Market Notable Highlights

Other leading players operating in the nanomechanical testing market are Micro Materials Limited, Testometric Co. Ltd., Quad Group Inc., Illinois Tool Works Inc., MTS Systems Corporation, Nanomechanics Inc., and Biomomentum Inc.

Nanomechanical Testing Market Segmentation

On the basis of offerings, the nanomechanical testing market can be segmented into:

Based on the end-use application, the nanomechanical testing market can be segmented into:

On the basis of instrument type, the nanomechanical testing market can be segmented into:

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Nanomechanical Testing Market to Witness Comprehensive Growth by 2028 - Science In Me

Sesderma Laboratories Communicates the Effectiveness of Lactyferrin Forte Solution in Boosting Immunity – P&T Community

VALENCIA, Spain, April 17, 2020 /PRNewswire/ -- Sesderma, a company specialized in Nanotechnology, has managed to encapsulate Lactoferrin (LF) and vitamin C in a lipid bubble or nanoliposome made of phosphatidyl choline, to boost the immunity of the body. The company has named this combination as Lactyferrin. The size of this liposome is 100 nm. The nano-liposome protects LF from its destruction by digestive juices and the intact protein passes through the duodenum and passes into the general circulation, where its bioavailability is very high. (Ishikado et al, 2005, Serrano et al).

LF plays an important role in immune regulation and defense mechanisms against bacteria, fungi and viruses. Antibacterial activity is related to the deprivation of the iron environment which is essential for bacterial growth. Antiviral activity is associated with the effect of acting as a competitor of cell membrane receptors commonly used by viruses to enter cells. Specifically, lactoferrin prevents the binding of virus to the host cell.

Lactyferrin can also suppress replication of the virus after the virus enters the cell as in the case of AIDS (Puddu et al, 1998).

Since liposome is made of soy lecithin (phosphatidyl choline), LF is biodegradable and biocompatible, which means it is very safe.

In a statement, Dr Gabriel Serrano founder of Sesderma and a dermatologist with more than 40 years of experiencehas said that in Valencia Spain, he personally has treated 75 COVID-19 patients with moderate to severe clinical features (4 of them intubated) and has administered Lactyferrin solution to all of them. The outcome is very satisfying and based on this outcome, a clinical trial on larger base of 300 patients has started in National hospitals Hospital Ifema (Madrid), Hospital La Paz (Madrid) and Hospital de Manises (Valencia)

Further, he said,"Many patients admitted to our local hospitals are patients over the age of 70 who have very low zinc levels, and this can contribute to the severity of the infection. Zinc supplements have been proposed in COVID-19 infections (Zhang & Liu, 2020). Interestingly, the combined administration of nano encapsulated LF and Zinc may exert a more potent antiviral effect."

For more information about Sesderma and Lactyferrin, visit https://www.sesderma.com/es_es/home

Photo: https://mma.prnewswire.com/media/1156675/Dr_Serrano_Founder_of_Sesderma.jpg Logo: https://mma.prnewswire.com/media/1156685/Sesderma_Logo.jpg

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Sesderma Laboratories Communicates the Effectiveness of Lactyferrin Forte Solution in Boosting Immunity - P&T Community

Ways to Support Immune Health – Fox 4

About Dr. Taz Bhatia, MD:Physician, best-selling author of The 21-Day Belly Fix and What Doctors Eat, international lecturer, integrative health expert, acupuncturist, certified nutritionist, wife and mom of a young son and daughter. Dr. Taz Bhatia M.D., a board certified physician and Founder and Medical Director of the nationally recognized Atlanta Center for Holistic and Integrative Medicine, is a specialist in the practice of integrative medicine, prevention and wellness, pediatrics, womens health and emergency medicine. Dr. Taz has been featured on media outlets including the Dr. Oz Show, The Weather Channel, TODAY, Access Hollywood, CNN, LIVE with Kelly and Michael. She is also a Dr. Oz Sharecare expert, a Huffington Post contributor, and served as a Prevention magazine columnist. She is an assistant professor at Emory University in Preventive and Integrative Medicine and continues to bring attention to the frequently ignored health issues of women and children. She currently serves as a Health Expert for MomCorps, MomDocs, Cancer Treatment Centers of America, and is a board member for Green of Hearts.Featured in Atlantas Top Docs, Dr. Taz Bhatia M.D., is a multi-talented and innovative physician and fellow of the University of Arizona Program in Integrative Medicine led by Dr. Andrew Weil, completing her fellowship in 2008.

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Ways to Support Immune Health - Fox 4

Journalist Chris Cuomo Is Setting Back Science Embracing Homeopathy And ‘Oxygenated Herbs’ As Coronavirus Treatment – Science 2.0

Cristina Cuomo, the wife of journalist Chris Cuomo, who had been setting progressive hearts aflutter with his jovial sort-of interviews with his brother, New York Governor Andrew Cuomo, before contracting COVID-19, has also tested positive for coronavirus.

Nothing surprising there. What is shocking is that she is founder of The Purist, a "wellness" (read: rich white people) brand which promotes woo like homeopathy, "energy medicine" and "oxygenated herbs" as how you prevent disease.And yet she got the disease anyway.

That has not stopped her and him from promoting all of the above plus marijuana oil, Peruvian tree bark and hemp. They think tinctures, organic food, and supplements FDA does not bother to validate because they are ridiculous will help.

None of those are medicine. They are not even alternative medicine or complementary medicine or integrative medicine or whatever folk medicine has rebranded itself as these days. The only thing missing is perineum sunning.

Is is any wonder that weeks later he is still sick?

In the interview with the Extra celebrity television show above she throws in the 'food is medicine' trope that we have been hearing about for years, while never answering the awkward question 'if food is medicine instead of just being food, why do healthy people need it?'

While there is nothing harmful in their beliefs in rubbish, they have money to burn, they are doing a disservice to the public who should not be wasting money on pseudoscience, because it is only beneficial in the way that Zicam is; buy it and you feel like you did something while you wait.

She must know it doesn't really work because she drops in the "integrative" term and admits she is giving him actual cold and allergy pills along with her nonsense. Why not play Belgian Symphonic Death Metal too? That could also be an "adjunct" to real medicine.

Cuomo cites Linda Lancaster, a Naturopath and Homeopath who nonetheless calls herself "Dr."(2) and makes supernatural claims like that "light harmonics" will change our energy and prevent disease, as will goat milk cleanses. She tells fellow woo believers the pretend Doctor created a "formula for those who had already contracted the virus, by adding antivirals. The main one is andrograghisa Chinese herb used for flu and viruses; the formula also includes olive leafwhich is antiviral and antifungaland now oil of oregano.

Here, buy these placebos and you may feel like you did something while you wait out COVID-19.

She says Cuomo also takes cannabidiol, which has never been shown to do anything, but claims Chris swears by it now.

If any of that were really preventative, how did Cristina get the disease? The reason is because it's all nonsense.

She runs an obscure website for fellow rich people, so whatever. Yet Chris is a journalist and his employer wants their brand to be taken seriously. None of us can do anything about the weird cosmic beliefs of our families but by indulging them, we are doing a huge disservice to the public. And in this case, to the credibility of science.

NOTES:

(1) Yes, $100 million of your tax dollars that should go toward science instead goes toward showing us each year that acupuncture still doesn't work.

(2)I bought a Ph.D. in Theoretical Phys Ed as a joke one time, so I can call myself Dr. with just as much credibility.

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Journalist Chris Cuomo Is Setting Back Science Embracing Homeopathy And 'Oxygenated Herbs' As Coronavirus Treatment - Science 2.0

Streaming online movie rentals to support Vickers and other art-house theaters – Harborcountry News

THREE OAKS The doors might be closed due to the COVID-19 pandemic, but the Vickers Theatre is still committed to bringing movies to Southwest Michigan residents.

On Friday, April 17, the Three Oaks venue starting offering virtual movie screenings on its website, vickerstheatre.com.

Through the streaming platform Virtual Cinema, people can watch movies on their smartphones, tablets and computers at home.

The distributors of independent cinemas are making first-run movies available to our theater, owner Judy Scully said in an email. These movies are available exclusively through art house-theater distributors.

The current rentals range from 3-5 days, and cost $10-$12.Approximately 50 percent of all proceeds will go to support the Vickers and other art house theaters during the COVID-19 pandemic, Scully said.Currently screening through Vickers website are:

Saint Frances: 106 minutes, not rated, comedy/drama. Aimless server Bridget hasnt yet achieved her goal of becoming a respected writer. When casual relations with a younger nice guy leads to an unexpected confrontation with potential motherhood, she manifests a job nannying a pint-sized spirit guide disguised as an obstinate 6-year-old.

The Dog Doc: 101 minutes, not rated, documentary. Dr. Marty Goldstein is a pioneer of integrative veterinary medicine. By holistically treating animals after other vets have given up, Goldstein provides a last hope for pet owners with nothing left to lose.

Bacurau: 132 minutes, not rated, drama/mystery/suspense. After the death of her grandmother, a doctor comes home to her matriarchal village in a near-future Brazil to find a succession of sinister events that mobilizes all of its residents.

Corpus Christi: 115 minutes, not rated, drama. Daniel experiences a spiritual transformation in a detention center. Although his criminal record prevents him from applying to the seminary, he has no intention of giving up his dream and decides to minister a small-town parish.

For more information, call (269) 756-3522.

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Streaming online movie rentals to support Vickers and other art-house theaters - Harborcountry News

Focus on what you will do. With Beau Henderson & Dr. Evian Gordon – Thrive Global

Retirement offers the unprecedented stage of life to boost the quality in the moment experiences, deepen existing social connections and choose new ones that nurture the brain, mind, soul and purpose.

I had the pleasure to interview Evian Gordon MD, PhD. Evian is Chairman of the Board for Total Brain. He has over 30 years experience in brain research and considered to be one of the originators of field of integrative neuroscience. He has authored more than 300 peer reviewed publications.

Thank you so much for joining us Dr. Gordon! Can you share with us the backstory about what brought you to your specific career path?

MyPhD was focused in serum lipids and heart attacks, in the days when cardiology was the golden highway of medicine. I was on a roll. And by chance, my PhD supervisor showed me the missing link fossil of the first hominids (primates) that stood upright. He pointed out to me that in the past 5 million years, the hominid brain has tripled in size. No other species has done anything like this.

I completed my PhD and switched my medical and science goals to set up a Standardized International Brain Function and Performance Database and use the insights from the database to build tools for self-transformation. That has remained my daily mission for 30 years.

Can you share the most interesting story that happened to you since you started your career?

Most of my early applied integrative neuroscience team had science and medical backgrounds. We were immersed in rational thinking and built a system to simultaneously measure electrical brain function, heart rate variability, sweat rate, breathing and response time to a range of activation tasks.

Tasks included nonconscious presentation of face emotions that were presented so rapidly (in a hundredth of a second) that the viewer was not aware of what was being presented.

We showed the viewers all the different face emotions (fear, disgust, sad, happy etc.) and analyzed the brain-body measures.

The first time we saw that nonconscious fear stimuli, it was processed 30 thousandths of a second faster than other emotions, we realized two shocking things:

Ever since that moment, those discoveries put a different lens into how we approach the function of the brain. More so, it shifted the focus to the motherload of the brains operating system how to best align nonconscious emotion intuition and conscious rational thinking.

Can you share a story with us about the most humorous mistake you made when you were first starting? What lesson or take-away did you learn from that?

I always thought I was the smartest person in the room.

The lesson I learned, was how little I knew then. And more so now.

None of us are able to achieve success without some help along the way. Is there a particular person who you are grateful towards who helped get you to where you are? Can you share a story about that?

Peter Cooper is the Founder of Cooper Investors, a $12 billion equities fund that only invests in long range opportunities (and whose team has interviewed over 1,000 CEOs to select their long range value latency strategies).

My company had set up the worlds largest standardized brain database (over a million datasets and featured in 300 publications) and built an online brain fitness platform to better understand your key brain capacities, train and track new habits, and generated what is likely to be the first objective test to predict treatment response in depression. We succeeded beyond our expectations, with over 30 highly-respected US companies using the online product.

However, by under-resourcing along with experiencing slow revenue growth, it resulted in stretching the company in too many directions to keep the mission on track. Therefore, it was leading investors to run out of patience and the company was running out of money.

Peter introduced me to Louis Gagnon and persuaded him to become the CEO of Total Brain. Louis has not only scaled the company but has brought fresh approaches to help destigmatize mental health around the globe.

What advice would you suggest to your colleagues in your industry to thrive and avoid burnout?

Work strategically harder.

But with a focus on finishing tasks!

Burnout is not about hard work.Its about being too stretched and a lack of finishing tasks.

And I would also advise them to only work with people with whom you are authentically aligned. Misalignment is the motherload of burnout.

If its not aligned, cut the chord as soon as possible.

What advice would you give to other leaders about how to create a fantastic work culture?

3 things:

1) A differentiated mission real differentiating ideas matter.

2) People alignment and be vigilant about not hiring self-righteous opportunists.

3) A growth mindset and a respectful, deep understanding of innovation and implementation of groundbreaking ideas.

With that in place: a differentiating product, a good product-market fit and the quickest paths to sustainable revenue, are more likely to happen.

Ok thank you for all that. Now lets move to the main focus of our interview. Retirement is a dramatic life course transition that can impact ones health. In some cases, retirement can reduce health, and in others it can improve health. From your point of view or experience, what are a few of the reasons that retirement can reduce ones health?

Can you share with our readers 5 things that one should do to optimize mental wellness after retirement? Please share a story or an example for each.

We live in the era of increasing awareness about age related memory mental health deterioration. There is however, growing evidence that although the brain diminishes in some tasks as it ages, it gains in other ways. Here are five factors that can help improve mental health after retirement.

1. Self-Awareness

Retirement inevitably increases the opportunity for self awareness and self reflection. The insights can be enhanced by a check-in of brain capacity strengths and mental health challenges, to magnify strengths and protect against mental health negativity.

2. Emotion Regulation

The widespread negative reality is that memory usually declines with age. However, neuroimaging evidence shows that emotional stability and negativity bias improves with age. The increased personal bandwidth of retirement provides an opportunity to magnify that strength.

3. Wisdom

The ability to see the patterns that matter increases with age. This ability allows an enhanced ability to make rapid and effective decisions that could increase the ability to savor ones retirement new opportunities. It is not coincidental that many great inventions and artistic outcomes have occurred late in late.

4. Quality Time and Social Connections

Retirement offers the unprecedented stage of life to boost the quality in the moment experiences, deepen existing social connections and choose new ones that nurture the brain, mind, soul and purpose.

5. Gratitude

The Positive Psychology Movement have highlighted the benefit to mental health of magnifying strengths, a positive solution focused attitude and the power of gratitude. When better to immerse in gratitude for what worked, than in retirement?

In your experience, what are 3 or 4 things that people wish someone told them before they retired?

1. Focus on what you will do, not what you wont do.

2. Dont generate self limiting age related beliefs. Go for it.

3. Its time to use your life learnt wisdoms.

4. Have deep gratitude for what is working for you, in health and life.

5. Stay on your lifes mission.

Is there a particular book that made a significant impact on you? Can you share a story?

Daniel Khaneman (2011): Thinking Fast and Slow. Macmillan.

I was shocked to discover the extent to which nonconscious emotions, intuition and biases drive most of our decisions.

In this book, Nobel Laureate Kahaneman and his collaborator Amos Tversky highlight through simple but elegant experiments, how unambiguously small random nudges nonconsciously shape most of our decisions.

This book has helped many people think afresh about how to best be aware and align their nonconscious intuition and their rational conscious thinking, to make better decisions.

You are a person of great influence. If you could start a movement that would bring the most amount of good to the most amount of people, what would that be? You never know what your idea can trigger.

Democratize the brain.

By providing the most engaging, impactful, intuitive and concrete online brain platform to align your nonconscious and conscious brain powers.

Can you please give us your favorite Life Lesson Quote? Do you have a story about how that was relevant in your life?

The only good is knowledge.

The only evil is ignorance.

Socrates (469399 BC).

This was one of the earliest seeds of the current brain revolution. It regularly inspires me on my 30 year journey, since I set up the worlds largest standardized brain function, performance database and applications Total Brain.com.

We are very blessed that some of the biggest names in Business, VC funding, Sports, and Entertainment read this column. Is there a person in the world, or in the US whom you would love to have a private breakfast or lunch with, and why? He or she might just see this if we tag them

Jim Kwik.

Because his mission is to create a smarter and more caring world by helping you rebuild our brains.

What is the best way our readers can follow you on social media?

YouTube Channel:https://www.dreviangordonsbrain.com/

LinkedIn:https://www.linkedin.com/in/evian-gordon-a94bbab1/Facebook,https://www.facebook.com/dr.evian.gordonTwitter,https://twitter.com/dreviangordon?lang=en

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Focus on what you will do. With Beau Henderson & Dr. Evian Gordon - Thrive Global

The Truth About Green Tea and Weight Loss – Pulse Ghana

Is green tea good for weight loss?

Research in humans and animals points to a resounding sort of. What that means:

A number of small but respectable clinical trials have found that overweight people who had green teaeither in drinkable form or in extract formlost more weight than people who didnt have any. Science being science, there are also a few studies that showed no benefit from green tea drinks or supplements. Overall, I would say it may assist modestly, says Kristin Kirkpatrick, R.D.N., consultant for Integrative and Lifestyle Medicine for the Cleveland Clinic.

In studies that found a weight-loss benefit in green tea, there was a trend toward weight loss or tea drinkers lost significantly more. But its not usually a total transformation. One small study conducted at Oklahoma State University, for instance, found that people who drank green tea or took green tea extract lost about 1.3 pounds more over 8 weeks than people who drank water. Some studies suggest even decaf green tea may have a benefit.

An older study found that among people who ate regularly and exercised 180 minutes a week, those who drank a beverage with the most biologically active compounds in green tea, called catechins, had a greater percentage change in abdominal fat (belly fat) than did people who got a drink with no catechins.

There are a number of theories on why green teaespecially the main catechin called epigallocatechin gallatemight help you out a bit if youre looking to lose weight.

Its possible that catechins in green tea may actually inhibit carbohydrate digestion and absorption, Kirkpatrick says, citing a report in the journal Scientific Reports that showed lower carb absorption after people downed a green tea extract.

I think some of the most promising ones are looking at green teas effects on the microbiome, she says. Research is increasingly finding that it alters the guts microbiome, and those changes could be what makes it helpful for dropping pounds.

Kirkpatrick gets a lot of questions from her clients on whether trendy matchathe powdered version of green teais as helpful as the green tea leaves that come in teabags or as loose tea. There havent been a ton of studies on matcha alone, she says. But adds that its reasonable to think its just as useful, as green tea comes out of the leaves of the plant, and matcha is made of the ground-up plants.

While numerous studies have looked at green tea extracts taken as supplements, Kirkpatrick urges people to get their green tea from the actual tea itself; in the most whole form possible.

There are more reasons than weight to drink green tea. Kirkpatrick points out the impressive benefits being found regarding green tea and the prevention of cancer. And then there are benefits in possibly preventing heart disease, potential memory benefits and other health boosters in the green stuff.

Weight loss is so multifaceted; green tea is not going to guarantee weight loss, Kirkpatrick says. But as long as youre not getting a sugared-up version of the stuff; green tea doesnt interfere with any medications youre taking; and youre not looking for it to be a weight-loss panacea, then go ahead and drink up.

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What Is the Immune System: Definition, Function and Parts – LIVESTRONG.COM

You probably know that your immune system plays an important role in keeping you healthy, but there's so much more to this critical system that works as our defense against infection.

Budding research says stress-relieving activities like meditation may benefit your immune system.

Image Credit: Marcin Wiklik/iStock/GettyImages

Here, two immunity experts break down the key parts of the system and what we mean when we talk about "strong" or "weak" immune responses.

Put simply: "The immune system is all the parts of the body that help to defend us against infection, whether by bacteria, virus, fungi, mold or parasites," Adam Lacy-Hulbert, PhD, who conducts research on immunity at the Benaroya Research Institute at Virginia Mason, tells LIVESTRONG.com.

The system is "a network of cells, channels and nodes" that work together, adds Cynthia Li, MD, integrative and functional medicine doctor and author of Brave New Medicine, a memoir about her path to healing her own autoimmune illness.

Let's take a closer look at these parts of a whole:

The immune system relies on lymphocytes aka white blood cells. Two types of these white blood cells T cells (thymus cells) and B cells (bone marrow- or bursa-derived cells) do a lot of the first-responding when something foreign threatens the body.

"These are the real workhorses of the immune system," Lacy-Hulbert says. "The job of T cells is to recognize and kill cells that are infected. The job of B cells is to make antibodies that are designed to bind specifically to viruses and bacteria, and to neutralize them to stop them from working."

Some of these B and T cells become memory cells; they remain dormant until they get the word that something they know how to fight (whether from experience with a vaccine or previous infection) has intruded. "That immune memory you have can last for a lifetime," Lacy-Hulbert says, which is important for fighting off infection faster and allowing the body to recover more quickly.

T cells and B cells are very important, but their laser-like focus can actually be problematic at times. "They don't know what to attack all the time," Lacy-Hulbert explains.

To balance this out, another part of the immune system the innate system, which is composed of a different group of cells acts as a kind of patrol, directing the B and T cells.

"Innate cells try to work out what's going on, go to lymph nodes, interact with T and B, and tell them what the deal is and whether they need to neutralize or kill [what's triggering the immune system]," Lacy-Hulbert says.

Innate immune cells are messengers; if you get a cut on your skin and that cut gets infected, innate immune cells "send out an alarm" to signal a need for help, Lacy-Hulbert says.

Neutrophils and Monocytes

These innate cells recruit a host of other immune cells, called neutrophils and monocytes, which speed their way to the site of injury and fight whatever they find.

Neutrophils and monocytes are early-wave defenders. They work hard, but without much specific knowledge about the infection, so they can cause damage to host cells, stimulate inflammation and are often responsible for the pus that can form inside a cut.

These cells hold down the fort, so to speak, for a few days until those specialized T and B cells arrive to fight the infection in a specific way.

Eating a healthy diet can help your immune system function at its best.

Image Credit: SDI Productions/E+/GettyImages

This is a valid question, but it may not be the right one to ask. That's because a strong immune system isn't always a helpful one, Lacy-Hulbert says.

"If you have a strong immune system, you might fight infection better, but you might have a stronger response of that initial collateral damage more inflammation than you actually need, more scar formation, maybe a wound takes longer to heal," he explains.

He believes that when we say "strong" immune system, what we really mean is a healthy immune system.

This answer isn't so clear cut, either.

"This is a debate and a problem we struggle with in immunology as a whole," Lacy-Hulbert says. "To me, a healthy immune system is one that makes good choices it's out there sampling things, checking out what's going on, and decides whether something is infected."

In other words, a healthy immune system is a good communicator: It works nimbly with each of its parts to tackle what it needs to while refraining from overreacting.

Having a compromised immune system isn't the same as having a "weak" one. To be immune-compromised means that a particular part of your immune system doesn't work as well as it should, Lacy-Hulbert says.

Those who may be considered immunocompromised may include people who don't have T or B cells, which can make it very difficult for them to fight off infections. In milder forms, a compromised immune system might be one that doesn't function properly maybe the B cells are produced, but the antibodies they produce aren't great at making memories.

The Centers for Disease Control and Prevention list the following as examples of people who may be immunocompromised:

Sometimes, it's the luck of the draw. Genetics play a big role in determining our immune strengths, weaknesses and overall abilities.

"There's a tremendous amount of genetic variability in terms of immune function and the capacity to detoxify or to transform certain foods or pollutants or infections," Dr. Li says. "But what we're finding right now is that a huge amount of the variability depends on the total lifestyle not just what we're eating, doing, drinking, breathing, but also what we're thinking and feeling."

Our emotions and thoughts have potential to majorly influence the immune system, says Dr. Li, whose free e-book, How to Shield Yourself Against COVID-19, explores this concept in more depth.

For this reason, she says relieving stress can positively affect the immune system. Practices like yoga, meditation and qigong can help put you in the "rest and restore state," she says, which, in turn, could help the immune system rest and restore, too.

While research around how emotions affect our immune systems is pretty nascent, Lacy-Hulbert says that "it's becoming more obvious that there is quite a specific link between the nervous system and the immune system."

Indeed, a March 2017 review in Dialogues in Clinical Neuroscience concluded that the emotional and immunological systems "talk" to one another, and that more research needs to be done in this area.

Still, Lacy-Hulbert says, there are "many things about the immune system and function of the body as a whole that we still don't really understand."

Read more stories to help you navigate the novel coronavirus pandemic:

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What Is the Immune System: Definition, Function and Parts - LIVESTRONG.COM

RECAP: Tuskegee University hosts ‘real talk’ COVID-19 webinar – Tuskegee University

April 16, 2020

Contact: Michael Tullier, APR, Office of Communications, Public Relations and Marketing

On Tuesday, April 14, doctoral fellows in Tuskegee Universitys Integrative Biosciences (IBS) Ph.D. Program hosted Real Talk About COVID-19: Facts, Updates and Actions a webinar addressing the epidemiology, symptoms, misnomers and other public health matters related to the current coronavirus pandemic.

Now more than ever, we want to serve our community, especially our brothers and sisters of color as they are significantly more vulnerable as a result of health disparities, lower incomes and inadequate access to health care and now, inadequate access to COVID-19 testing, explained Lauren Mayo, an IBS Ph.D. fellow, as she cited the universitys status as a land-grant institution, as well as its outreach and service mission.

The webinar featured subject-matter expertise provided Muhammad Gamal Omar, DVM, who also is an IBS Ph.D. fellow. His experience includes research with RNA viruses that behave similarly to SARS-CoV-2 the virus that causes the COVID-19 disease.

View the full webinar program below:

The session was presented in partnership with the Graduate Public Health Program, College of Agriculture, Environment and Nutrition Sciences, College of Arts and Sciences, College of Veterinary Medicine, the Tuskegee University Cooperative Extension Program, and the Community Engagement Subcommittee of the Tuskegee University Community Health Task Force.

2020, Tuskegee University

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Are Robust Financials Driving The Recent Rally In Avecho Biotechnology Limited’s (ASX:AVE) Stock? – Yahoo Finance

Avecho Biotechnology's's (ASX:AVE) stock is up by a considerable 200% over the past month. Given the company's impressive performance, we decided to study its financial indicators more closely as a company's financial health over the long-term usually dictates market outcomes. Particularly, we will be paying attention to Avecho Biotechnology's ROE today.

Return on equity or ROE is an important factor to be considered by a shareholder because it tells them how effectively their capital is being reinvested. Simply put, it is used to assess the profitability of a company in relation to its equity capital.

View our latest analysis for Avecho Biotechnology

The formula for ROE is:

Return on Equity = Net Profit (from continuing operations) Shareholders' Equity

So, based on the above formula, the ROE for Avecho Biotechnology is:

18% = AU$850k AU$4.8m (Based on the trailing twelve months to December 2019).

The 'return' is the income the business earned over the last year. So, this means that for every A$1 of its shareholder's investments, the company generates a profit of A$0.18.

So far, we've learnt that ROE is a measure of a company's profitability. Based on how much of its profits the company chooses to reinvest or "retain", we are then able to evaluate a company's future ability to generate profits. Assuming everything else remains unchanged, the higher the ROE and profit retention, the higher the growth rate of a company compared to companies that don't necessarily bear these characteristics.

To begin with, Avecho Biotechnology seems to have a respectable ROE. Further, the company's ROE compares quite favorably to the industry average of 11%. This certainly adds some context to Avecho Biotechnology's exceptional 32% net income growth seen over the past five years. However, there could also be other causes behind this growth. Such as - high earnings retention or an efficient management in place.

Next, on comparing Avecho Biotechnology's net income growth with the industry, we found that the company's reported growth is similar to the industry average growth rate of 32% in the same period.

ASX:AVE Past Earnings Growth April 17th 2020

The basis for attaching value to a company is, to a great extent, tied to its earnings growth. What investors need to determine next is if the expected earnings growth, or the lack of it, is already built into the share price. This then helps them determine if the stock is placed for a bright or bleak future. One good indicator of expected earnings growth is the P/E ratio which determines the price the market is willing to pay for a stock based on its earnings prospects. So, you may want to check if Avecho Biotechnology is trading on a high P/E or a low P/E, relative to its industry.

Avecho Biotechnology doesn't pay any dividend to its shareholders, meaning that the company has been reinvesting all of its profits into the business. This is likely what's driving the high earnings growth number discussed above.

In total, we are pretty happy with Avecho Biotechnology's performance. In particular, it's great to see that the company is investing heavily into its business and along with a high rate of return, that has resulted in a sizeable growth in its earnings.

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If the company continues to grow its earnings the way it has, that could have a positive impact on its share price given how earnings per share influence long-term share prices. Remember, the price of a stock is also dependent on the perceived risk. Therefore investors must keep themselves informed about the risks involved before investing in any company.

You can see the 3 risks we have identified for Avecho Biotechnology by visiting our risks dashboard for free on our platform here.

If you spot an error that warrants correction, please contact the editor at editorial-team@simplywallst.com. This article by Simply Wall St is general in nature. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. Simply Wall St has no position in the stocks mentioned.

We aim to bring you long-term focused research analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Thank you for reading.

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Are Robust Financials Driving The Recent Rally In Avecho Biotechnology Limited's (ASX:AVE) Stock? - Yahoo Finance

Cuban Biotechnology develops 15 projects to face the pandemic – Tehran Times

Cuban scientists are working on 15 biotechnological projects to deal with COVID-19 that encompass diagnosis and treatment, officials from the BioCubaFarma entity announced.

Orlando Prez Rodrguez, director of Science and Innovation at BioCubaFarma, said that all clinical research and interventions have been duly authorized by Cuban regulatory entities and will be timely evaluated and reported to publicize Cuba's experience in this field.

He explained that 6 of the 15 projects are focused on treatment, the same number is prophylactic, two are diagnosticians and a medical team.

He added that the products focus on increasing people's innate immunity, reducing the viral load at the beginning of the disease and reducing the hyperinflammatory reaction in patients who develop it, especially in vulnerable groups (older adults or those with pathologies of antecedent).

As a sample of the responsiveness of Cuban Biotechnology, 9 of these projects are already in the phase of intervention trials or clinical studies and six are still in the research and development phase in laboratories, in addition to others in the design or early research.

He pointed out that in the treatment, in the initial stage Interferon Alpha 2B is used, for the management of the inflammatory reaction produced by COVID-19, the monoclonal antibody of the Immunoassay Center and a peptide from the Center for Genetic and Biotechnological Engineering are studied (CIGB).

Most products focus on the use of prophylactics, including nasal administration of interferon Alfa (to stimulate immunity), biomodulin-T (for those over 60 years of age), transfer factor (stimulates immunity in vulnerable groups), CIGB 2020 (immuno enhancer) and a vaccine candidate from the Finlay Institute (contains components of the Cuban meningitis vaccine).

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Cuban Biotechnology develops 15 projects to face the pandemic - Tehran Times