Large-scale analysis links glucose metabolism proteins in the brain to Alzheimer’s disease biology – National Institutes of Health

News Release

Monday, April 13, 2020

In the largest study to date of proteins related to Alzheimers disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers. The findings suggest that sets of proteins that regulate glucose metabolism, together with proteins related to a protective role of astrocytes and microglia the brains support cells are strongly associated with Alzheimers pathology and cognitive impairment.

The study, part of the Accelerating Medicines Partnership for Alzheimers Disease (AMP-AD), involved measuring the levels and analyzing the expression patterns of more than 3,000 proteins in a large number of brain and cerebrospinal fluid samples collected at multiple research centers across the United States. This research was funded by the National Institutes of Healths National Institute on Aging (NIA) and published April 13 in Nature Medicine.

This is an example of how the collaborative, open science platform of AMP-AD is creating a pipeline of discovery for new approaches to diagnosis, treatment and prevention of Alzheimers disease, said NIA Director Richard J. Hodes, M.D. This study exemplifies how research can be accelerated when multiple research groups share their biological samples and data resources.

The research team, led by Erik C.B. Johnson, M.D., Ph.D, Nicholas T. Seyfried, Ph.D., and Allan Levey, M.D., Ph.D., all at the Emory School of Medicine, Atlanta, analyzed patterns of protein expression in more than 2,000 human brain and nearly 400 cerebrospinal fluid samples from both healthy people and those with Alzheimers disease. The papers authors, which included Madhav Thambisetty, M.D., Ph.D., investigator and chief of the Clinical and Translational Neuroscience Section in the NIAs Laboratory of Behavioral Neuroscience, identified groups (or modules) of proteins that reflect biological processes in the brain.

The researchers then analyzed how the protein modules relate to various pathologic and clinical features of Alzheimers and other neurodegenerative disorders. They saw changes in proteins related to glucose metabolism and an anti-inflammatory response in glial cells in brain samples from both people with Alzheimers as well as in samples from individuals with documented brain pathology who were cognitively normal. This suggests, the researchers noted, that the anti-inflammatory processes designed to protect nerve cells may have been activated in response to the disease.

The researchers also set out to reproduce the findings in cerebrospinal fluid. The team found that, just like with brain tissue, the proteins involved in the way cells extract energy from glucose are increased in the spinal fluid from people with Alzheimers. Many of these proteins were also elevated in people with preclinical Alzheimers, i.e., individuals with brain pathology but without symptoms of cognitive decline. Importantly, the glucose metabolism/glial protein module was populated with proteins known to be genetic risk factors for Alzheimers, suggesting that the biological processes reflected by these protein families are involved in the actual disease process.

Weve been studying the possible links between abnormalities in the way the brain metabolizes glucose and Alzheimers-related changes for a while now, Thambisetty said. The latest analysis suggests that these proteins may also have potential as fluid biomarkers to detect the presence of early disease.

In a previous study, Thambisetty and colleagues, in collaboration with the Emory researchers, found a connection between abnormalities in how the brain breaks down glucose and the amount of the signature amyloid plaques and tangles in the brain, as well as the onset of symptoms such as problems with memory.

This large, comparative proteomic study points to massive changes across many biological processes in Alzheimers and offers new insights into the role of brain energy metabolism and neuroinflammation in the disease process, said Suzana Petanceska, Ph.D., program director at NIA overseeing the AMP-AD Target Discovery Program. The data and analyses from this study has already been made available to the research community and can be used as a rich source of new targets for the treatment and prevention of Alzheimers or serve as the foundation for developing fluid biomarkers.

Brain tissue samples came from autopsy of participants in Alzheimers disease research centers and several epidemiologic studies across the country, including the Baltimore Longitudinal Study of Aging (BLSA), Religious Orders Study (ROS) and Memory and Aging Project (MAP), and Adult Changes in Thought (ACT) initiatives. The brain collections also contained samples from individuals with six other neurodegenerative disorders as well as samples representing normal aging, which enabled the discovery of molecular signatures specific for Alzheimers. Cerebrospinal fluid samples were collected from study participants at the Emory Goizueta Alzheimers Disease Research Center. These and other datasets are available to the research community through the AD Knowledge Portal, the data repository for the AMP-AD Target Discovery Program, and other NIA supported team-science projects operating under open science principles.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

The research in this study is funded by NIH grants R01AG053960, R01AG057911, R01AG061800, RF1AG057471, RF1AG057470, R01AG061800, R01AG057911, R01AG057339, U01AG061357, P50AG025688, RF1AG057470, RF1AG051633, P30AG10161, R01AG15819, R01AG17917, U01AG61356, R01AG056533, K08NS099474, U01AG046170, RF1AG054014, RF1AG057440, R01AG057907, U01AG052411, P30AG10124, U01AG046161, R01AG050631, R01AG053960, R01AG057339, U01AG061357, P50AG005146, U24NS072026, and P30AG19610.

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. For information about a broad range of aging topics, visit the main NIA website and stay connected.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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Large-scale analysis links glucose metabolism proteins in the brain to Alzheimer's disease biology - National Institutes of Health

Is Testosterone Therapy Good Or Bad For The Heart? Or Is It The Estradiol? – Anti Aging News

Article courtesy of: T. Hertoghe, MD, author of Testosterone, the Therapy for Real Gentlemen

In recent years, a few studies have shown adverse effects of testosterone therapy on the heart: higher risks of coronary heart disease, myocardial infarction, or stroke.

The findings of adverse cardiovascular effects of testosterone therapy is in sharp contrast with the information emerging from scientific studies on testosterone. A mans heart, arteries, and brain need testosterone to function well. Testosterone is possibly the most important hormone for a mans muscles. The heart is made of striated muscle fibers, and the arteries, also those that go through the brain, are mainly made of smooth muscle cells with a thin layer of endothelial cells inside, all responsive to testosterone.

Only a few low-quality studies show adverse effects of testosterone therapy on the brain and heart

The number of studies that show adverse cardiovascular effects of testosterone therapy is very small in comparison with the much greater number of studies showing protective effects: 5 negative studies (including one study that shows a mixture of beneficial and adverse effects on coronary arteries) compared to 17 studies showing neutral effects (no adverse effects) and 58 published trials that show cardio- and cerebrovascular protection of testosterone therapy. Furthermore, in approximately 100 studies, high testosterone levels are associated with cardiovascular protection, whereas it is difficult to find a single study showing the opposite. Moreover, it is worth noticing that the studies that show cardiovascular adverse effects of testosterone therapy present important biases and quality errors that make them less trustable.

Excessive conversion of testosterone to estradiol may be the explanation behind the unexpected unfavorable results

There might be some truth behind the unexpected adverse effects of testosterone found in the five studies. During testosterone therapy some of the testosterone converts into the female hormone estradiol. In some men, excessive amounts of testosterone can convert to estradiol. Men with high estradiol levels tend to develop significantly more atherosclerosis, coronary heart disease, arterial hypertension, and stroke. When estradiol levels become excessive, the estradiol tends to block testosterone receptors, blocking as a result the protective effect of testosterone on the cardiovascular system. If this is the real explanation for why testosterone therapy may cause cardio and cerebrovascular problems in some men, then all studies that examine the effect of testosterone therapy on men should include a measurement of the serum estradiol levels. In fact, because of the risks presented by high estradiol levels in men, the follow-up of any testosterone treatment should include regular measurements of estradiol next to that of testosterone and the other important tests related to testosterone.

To access the relevant data on testosterone deficiency, testosterone therapy, and their association with cardiovascular disease on the International Hormone Society website, in the Evidence-based hormone therapies section (available soon).

To get more references and practical information on testosterone therapy, read my 600-page book for physicians, Testosterone, the Therapy for Real Gentlemen.

To get practical and in-depth training on testosterone therapy and come attend the hormone therapy workshop in Orlando on August 21-22, 2020. Check out the Evidence-based hormone therapy workshop here, which will be available at the A4M 28th Annual Spring Congress being held in Orlando, Florida on August 20-22, 2020.

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Is Testosterone Therapy Good Or Bad For The Heart? Or Is It The Estradiol? - Anti Aging News

7 Emerging Uses of Calendula Tea and Extract – Healthline

Calendula, a flowering plant also known as pot marigold, can be served as a tea or used as an ingredient in various herbal formulations.

While the tea is made by steeping the flowers in boiling water, the extract is derived from both the flowers and the leaves (1).

Despite its slightly bitter taste, calendula tea is a traditional remedy used in folk medicine because of its ascribed therapeutic properties. Meanwhile, you can find the extract in oils, ointments, and tinctures.

Here are 7 potential benefits of calendula tea and extract.

Antioxidants are beneficial compounds that neutralize the harmful effects of oxidative stress in your body (2).

Calendula extract possesses several potent antioxidants, including triterpenes, flavonoids, polyphenols, and carotenoids (1, 3, 4, 5, 6).

Additionally, it boasts anti-inflammatory compounds, such as tumor necrosis factor alpha (TNF). While inflammation is a normal bodily response, chronic inflammation is linked to multiple conditions, including obesity, metabolic syndrome, and type 2 diabetes (7, 8).

In a study in rats fed monosodium glutamate (MSG), calendula extract significantly reduced oxidative stress and reverted the depletion of antioxidant levels by up to 122% (9).

MSG is a popular flavor enhancer that may cause headaches, dizziness, and numbness in sensitive individuals or when consumed in high doses (9).

While these results are promising, further human research is needed.

Calendula contains numerous compounds that may fight oxidative stress and inflammation in your body.

Calendula extract found in oils, ointments, and tinctures may be used topically to treat wounds and ulcers. You can also apply the tea to your skin via a cloth compress or spray bottle. However, its unclear whether drinking the tea offers the same effects.

Test-tube and animal studies indicate that calendula extract may regulate the expression of certain proteins that promote wound healing (10).

One test-tube study determined that calendula extract increased the amount of collagen in wounds as they healed. This protein is necessary to form new skin (11).

In a 12-week study in 57 people, 72% of those treated with calendula extract experienced complete healing of venous leg ulcers, compared with 32% in the control group (12).

Similarly, in a 30-week study in 41 adults with diabetes-related foot ulcers, 78% of participants achieved complete wound closure after daily treatment with calendula spray (13).

You can apply calendula to your skin in various forms to promote wound and ulcer healing.

Calendulas antioxidant content may provide anti-tumor effects.

Test-tube studies suggest that calendulas flavonoid and triterpene antioxidants may fight leukemia, melanoma, colon, and pancreatic cancer cells (14, 15, 16, 17).

Research indicates that the extract activates proteins that kill cancer cells while simultaneously blocking other proteins that would otherwise interfere with cell death (18).

Nevertheless, research in humans is lacking. Calendula tea or other calendula products should never be used as a cancer treatment.

Several calendula compounds may combat certain cancer cells, but human studies are necessary.

Calendula extract is known for its antifungal and antimicrobial properties (19).

Notably, in one test-tube study, oil from calendula flowers proved effective against 23 strains of Candida yeast a common fungus that can cause oral, vaginal, and skin infections (20, 21).

Another test-tube study indicated that calendula extract inhibits the growth of leishmania, the parasite responsible for leishmaniasis a disease that may produce skin sores or affect internal organs, such as your spleen, liver, and bone marrow (22, 23).

You can apply calendula oils, ointments, cloth compresses, or sprays directly to your skin but remember that research in humans is needed, so its unclear how effective these treatments are.

Calendula may offer antifungal and antimicrobial properties, but studies in humans are lacking.

Calendula may help treat oral conditions, such as gingivitis.

Gingivitis, which is characterized by chronic inflammation of the gums, is one of the most common oral diseases (24).

In a 6-month study in 240 people with gingivitis, those given a calendula mouthwash experienced a 46% reduction in their inflammation levels, compared with 35% in the control group (24, 25).

Whats more, a test-tube study determined that a calendula-based mouthwash reduced the number of microorganisms on suture materials used for tooth extraction (26).

The studies attributed these effects to calendulas potent anti-inflammatory and antimicrobial properties.

Furthermore, gargling calendula tea is said to relieve sore throats although the evidence is anecdotal (27).

Calendulas anti-inflammatory and antimicrobial properties may aid oral health by combatting gingivitis and microbial growth.

Calendula extract is widely utilized in cosmetics, including creams and ointments.

Both test-tube and human studies show that calendula extract may enhance skin hydration and stimulate its firmness and elasticity, which may delay signs of aging (28, 29).

These effects are likely due to its antioxidant content, which may reduce skin damage caused by oxidative stress (28, 30).

Exposure to ultraviolet (UV) radiation is the leading cause of oxidative stress in the skin. Interestingly, one test-tube study determined that calendula oil has a sun protection factor (SPF) of 8.36 (30).

As such, sunscreens formulated with calendula oil may safeguard against sunburn.

Lastly, a 10-day study in 66 children with diaper rash determined that calendula ointment may work as a safe and effective treatment (31).

Calendulas antioxidants and SPF may reduce skin damage, combat skin aging, and treat diaper rash.

Many people claim that calendula has other uses, but few of these are supported by science.

A handful of studies indicate that calendula may improve heart health, treat muscle fatigue, and relieve sore nipples. However, no scientific evidence supports its other uses, which include regulating menstruation and clearing acne.

The Food and Drug Administration (FDA) considers calendula safe for general use (32).

However, while it may improve skin health in some people, skin contact may result in allergic reactions in others. Therefore, you should test your skins reaction by applying a small amount of any calendula-based product prior to using it (27).

People with allergies to other plants from the Asteraceae family, such as German chamomile and mountain arnica, may be more prone to a calendula allergy (35).

Furthermore, it may be best to avoid calendula products while pregnant to reduce your risk of miscarriage, given the herbs alleged menstruation effects.

Lastly, a review of 46 studies determined that calendula may interfere with sedatives and blood pressure medications. If youre taking either of these, you may wish to avoid this herb (36).

While calendula is generally recognized as safe by the FDA, pregnant women and people taking sedatives or blood pressure medications may want to avoid it.

Calendula, a flowering plant, is packed with beneficial plant compounds that may provide antioxidant, anti-inflammatory, antifungal, and wound healing effects.

Its commonly taken as an herbal tea and used in various topical creams.

Still, further human research is necessary, as most of the evidence relies on test-tube or animal studies.

Lastly, you should avoid calendula if youre pregnant or taking sedatives or medications to lower blood pressure.

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7 Emerging Uses of Calendula Tea and Extract - Healthline

Coronavirus: Treatment hope with everyday antibiotics – expressandstar.com

With the coronavirus pandemic maintaining its grip on the world, the hunt for specific treatments continues.

There is some hope in existing medication that has been approved for use in other conditions.

The latest hope comes from the use of antibiotics that cost the NHS about 10p per person, per day.

Professor Michael Lisanti from the University of Salford, said: We have identified several classes of existing MHRA/FDA-approved drugs that, we believe, will help to target the Covid-19 coronavirus, for both preventing and treating the disease and at a very low cost to the NHS.

The researchers are proposing a new framework for understanding how ageing and senescence deterioration with age could contribute to the lethality of Covid-19 in older patients.

Many of these approved drugs are antibiotics, such as doxycycline and azithromycin, which strongly inhibit both inflammation and viral replication.

In his latest article Professor Lisanti, chairman of translational medicine at Salford discusses how senescent cells which perform functions such as tumor suppression and wound healing may be the key to understanding how to treat Covid-19 infections, with the drugs.

In the paper published in the Aging journal Professor Lisanti and his team propose these medications could be effective, and would be readily available.

One of the proposed drugs is the antibiotic azithromycin, which is widely used to treat chest, sinus, throat and skin infections, as well as sexually transmitted diseases.

The researchers say that in combination with hydroxychloroquine which is also being trialled as a possible treatment, azithromycin was recently shown to inhibit the replication of Covid-19, in a clinical trial in France.

However, the effects of azithromycin alone were not assessed.

Basically, its a very simple idea.

If you look at the host receptors of Covid-19, they are related to senescence (biological ageing).

Two proteins have been proposed to be the cellular receptors of Covid-19 one is CD26 a marker of senescence, and the other, ACE-2, is also associated with senescence.

So, older people would be predicted to be more susceptible to Covid-19, exactly as is observed clinically in patients.

This could increase their probability of infection, and would explain the increased fatality of Covid-19 infection in older patients.

All of this could be related to advanced chronological age and senescent cells, Prof Lisanti said.

He added that if that was the case, interventions could be made by targeting and removing senescent cells or by using other classes of anti-ageing drugs.

The researchers said the drugs now need to be tested in clinical trials, and with vaccines potentially not being available for around 12 months

Vaccines could be 18-to-24 months away, so it would be necessary to approved drug candidates, to re-purpose, to prevent or treat Covid-19 in the meantime.

And other drugs are already being trialled to see if they can be used in the fight against coronavirus.

This includes a trial of remdesivir, that was initially developed to treat Ebola and Marburg virus infections, which is being led by University College London.

Elsewhere, researchers a massive trial which is being coordinated by researchers at the University of Oxford, will look at the effectiveness of drugs and steroids, such as Lopinavir/Ritonavir, which is currently authorised as an anti-HIV medicine, and hydroxychloroquine, a treatment for malaria.

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Coronavirus: Treatment hope with everyday antibiotics - expressandstar.com

Why Gua Sha Is the Original Form of At-Home Self-Care – Vogue

A few days later I try the no-frills version to alleviate some persistent tension and fatigue at Oakland Foot Health Center, a walk-in storefront not dissimilar to the medical-massage clinics in China serving working-class men on their lunch breaks, aunties, grandmas, and, once upon a time, me. Gua sha has saved many peasants lives, my masseuse tells me in Mandarin as she scrapes my back during an hour of body acupressure with gua sha, which goes for a modest $60. When I ask what her tool is made of, she chuckles. Its supposed to be ox horn, but it looks like plastic to me. I leave with the same drained lightness coursing throughout my body that I felt after my experience at Ritual SF.

So why, I wonder, would I pay $285 to visit Crystal Cave LA, a healing hut in Santa Monica where Julie Civiello Polier performs her much-blogged about shamanic gua sha facials three days a week? Described as a meditative journey and intuitive reading, the whole concept makes me laugh before I even arrive. I love how gua sha gives us a tool that is charged by the person using it and the person receiving it, Civiello Poliera petite blonde former actortells me of her popular treatments purported energy exchange. At least Ill get a nice nap out of this, I think to myself as I close my eyes.

But when Civiello Polier places crystals on my various chakrasincluding an amethyst at my feet that she claims wants to go home with meI do feel something, a deep radiating warmth that allows my overthinking mind to let go. As she performs the facial gua sha, at one point even sticking her fingers inside my mouth for a deep, tension-relieving buccal massage, she takes long audible breaths that lull me into an ASMR-like trance. Afterward, my skin does not look totally transformed. Theres a limitation to the results you can get with gua sha, confirms Julia Tzu, M.D., a clinical assistant professor at NYUs Ronald O. Perelman Department of Dermatology, who recommends fillers, such as Restylane Lyft, for longer-lasting tightening. But a superficial result seems besides the point; I feel like Ive been lifted from the inside out.

I step out of Civiello Poliers studio into the bright Southern California sun, conflicted by the commodification of Chinese folk medicine and home remedies. But the craving for a more holistic conception of beauty feels real. I remember something Huntzinger told me when describing her work. These days, society is so yang, so active. With the advent of social media, the yang has been overstimulated to such a degree, and the yin has not been nourished, she explains. Maybe, in a paradoxical twist, #guasha has risen precisely from our innate desire to restore focus on the yinthe darker, interior, reflective parts of ourselves.

People are not just getting a skin-deep treatment, Zhang confirms of what she sees as the techniques actual rejuvenating benefits. She slips into Chinese for a moment for emphasis, and I notice that in place of antiaging she uses the words yang shenga phrase Ive heard often from my aunts and grandmothers when telling me to take care. Remembering how the Chinese women in my life have always emphasized that to be healthy is to be beautiful, Zhangs message suddenly makes sense. After all, Id never thought of yang sheng as simply utilitarian: It translates more directly to nourishing life.

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Why Gua Sha Is the Original Form of At-Home Self-Care - Vogue

With season cancelled, Pioneer staffer lending a hand to healthcare workers – FOX 31 Denver

DENVER (KDVR) She is a Pioneer through and through. Kelsey Bigham is Denvers Director of Hockey Operations, one of only three full-time female staff members to hold that title in all of Division-I hockey.

For the Pios team, she does it all. Managing meals, setting up road trips, travel plans, team video, everything in between, Bigham says of her daily duties.

But her skills go far beyond her day job.A few years ago, she became a certified EMT while she was still a full-time student at Colorado State.

I picked up shifts when I could basically, it was a lot of weekend nights, she remembers.My mom was a flight nurse and my dad is a flight paramedic so I have an extensive family background in medicine.

Kelsey is now a full time member of the hockey world, but in many ways her heart is still with those in the medical field. She wanted to help in any way she could during the coronavirus pandemic, so shes putting another skill of hers to use.

She recently began sewing masks for healthcare workers and sending them all around the country.

Since I was an EMT and so many of my friends are medical professionals, I felt an overwhelming sense that I should be alongside them, she says. I should be fighting this thing with them, but Im not. So I tried to find a way that I can make myself useful and help out where I could.

In just a week and a half, shes made more than 100 masks and the response has been nothing but gratitude.

They like them! Theyre so thankful. A lot of these people are getting less than one N95 mask per shift, so anything they can wear over that to help protect the longevity of the mask is very helpful.

And this multi-skilled Pioneer doesnt plan on slowing down any time soon.

Ill keep doing it until JOANN Fabrics stops sending me fabric and people stop needing them, she says.

If youre able to sew and interested in learning how to make these masks, Bigham suggests checking outDenas Mask Making Army on Facebook for more information.

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With season cancelled, Pioneer staffer lending a hand to healthcare workers - FOX 31 Denver

Dick Magee: Time to turn on the lights – Sturgis Journal

Ive been talking to neighbors and a few of my coffeeclutch compatriots about the pandemic. Were just a bunch of regular guys. Theres not an MD or PhD in the crowd. The best we might do would be a Distinguished Scholar or two from the School of Hard Knocks. Thats about it.

But we know something about running a successful business or a farm. Weve been around, seen a lot and know a lot about small town America. Of an older generation, we may have accrued a fair share of wisdom. And now were trying to make sense out of what we see happening in the country and exploring common sense steps that could help set things straight.

We know we're at war with a virus, an enemy so small we cant see it, or swat it or step on it. We dont even know where it is. Its just out there, somewhere, floating in the air. And best we can do is stay home, wash our hands, avoid other people and hope this thing misses us.

Were held captive. And while we sit, and stew and suffer through the quarantine, we watch our economy begin to dissolve before our eyes. And thats more frightening than the virus. Ill take my chances with the virus, and Im an at-risk senior citizen. I see the virus as relatively short-term menace the possible collapse of the country as an unmitigated disaster.

Most of my wise men conclude we simply cant just sit and wait and hope, prisoners in an inescapable lockdown. Weve got to get real. In a war, no matter how hard we try, we cannot avoid casualties. In an effort to save the few, we cannot ignore the many the country itself. Safeguarding the health of our economy is as important as protecting the health of our people. Its the engine that gives us the financial strength to endure the calamities of the present, to recover in smart order and to return to the prosperity of yesterday. The economy is the lifes blood of the nation.

The so-called stimulus money doesnt stimulate recovery. It helps to reduce loss. The government seems to be in a haphazard spending frenzy. The Democrats gleefully add pork to every bill. And more astronomical spending is forecasted in the future. Im uncertain as to its effect on the virus. But I do know the spending of trillions of dollars now can lead to a crippling inflation tomorrow.

The challenge now is preventing the cure from becoming worse than the disease. The stimulus money will not do the job. Its like using a Band-Aid to cover a hurt. We cant bankrupt the country. Its time to get our businesses back on line put our people back to work, give the country a much-needed tonic. It will show were on our way back. It will build confidence, boost morale and get us back into to our American can do spirit.

Certainly, it can be a gradual process. Different areas of the country require different plans of action. But right now, we seem out of balance. Early models projecting the progress and the fatality rates of the virus have been markedly overblown. The models included many assumptions (best guesses) that have been proven wrong. Wall Street Journal reports, Projections based on modeling the course of the virus are shifting as more information becomes available. The good news is that conditions in most of the country are less dire than early models predicted. Dr. Ben Carson, secretary of Housing and Urban Development, opines that about 98% of the people who get the virus will recover. We cant operate out of hysteria. The use of hydroxychlorquine and other developing medicines will further reduce the impact and longevity of the disease. This requires that the edicts of government based on the early models be updated and the quarantine relaxed.

Well beat the virus. But in doing so, we cant afford to decimate our industrial/business base. Certainly there are risks in moving back to a normal business environment even when its done in stages. The virus could hang on for a while, even though there is mounting evidence that such simple tasks as washing hands, maintaining distance, wearing masks and employing new medicine cuts the risk. My assumption is that our giant corporations and the shops along Main Street will find new ways of doing business once their doors open up. Theyre good at that. Theyll do it in ways that offer protection to their employees and to the rest of us. And the county will avoid bankruptcy and the dreaded inflation. Yes, there will be casualties our casualties of war. But they will be in balance with the needs of our country as a whole. It will survive. Our millions will be back to work. Our businesses will prosper. Our savings and investments will stay whole. And as a nation, well be stronger than ever before. What weve learned in the battle will make it so.

But we cant afford to dither. We must demand that politicians to push politics aside, that they look to the needs of the country, not to those of the party. We must act and turn the lights back on while theres still time.

Thats how it seems to us, some of the regular guys, the little people who hope the big people in Washington and in the governors mansions do the job and do it right. Our job is to keep watch, let them know what we think, make sure they know were tired of the constant sniping and politics that puts the rest of us in danger greater than that of the virus. Well remember who did what and why and come November, well do what we think right.

Dick Magee is a resident of Klinger Lake and a frequent columnist for the Journals Viewpoints page.

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Dick Magee: Time to turn on the lights - Sturgis Journal

BOOK REVIEW: One Oncologist’s Journey With a Patient to the Outcome We All Face – AJMC.com Managed Markets Network

Patel, Kashyap. Dying Without Fear: The Pursuit of Eternity. Penguin Random House India; 2020.

Yes, I can defi nitely share my journey with you. I will also sharesome of my other patients stories with you, if you believe theywill help.When do you want to begin?

Maybe we can meet once a week at lunch time, here under thisbeautiful copper dome. Could we start tomorrow?

So beings a series of conversations which unfold in the captivatingrelationship between Harry Falls, a former pilot with theBritish Royal Air Force and later a fl ight instructor in the UnitedStates, and Kashyap Patel, MD, author of Dying Without Fear,which will be available soon from Penguin Random House India.Production delays due to coronavirus disease 2019 will require theApril 2020 launch date to be rescheduled. (See Cover.)

Readers of Evidence-Based Oncology (EBO) will recognizePatel as an associate editor and contributing author. Patel is amedical oncologist/hematologist and the chief executive officerof Carolina Blood and Cancer Care Associates, based in RockHill, South Carolina. Having grown up in India and practicedmedicine on 3 continents, he has devoted tremendous personaltime and travel to nourish his interest in world religions andculturesparticularly to gain insight into the universal humanexperience of death.

Falls, married to one of Patels colleagues, died within months ofa diagnosis of lung and liver cancer. Yet, amid the challenges of hisillness, Falls was incredibly fortunate. He had the rare opportunityto discuss his questions about death with Patel, a physician andfriend who was exceptionally well-equipped to help Falls prepare for what the aviator called his ultimate and infi nite journey.Throughout the last months of Falls life, the pair met weekly toexamine death from multiple vantage points: physical, emotional,relational, cultural, and spiritualreligiousphilosophical. Theirencounters provide the foundation of Dying Without Fear.

Patels medical facility was well-designed for conversationswith Falls. The doctor explains, My clinic, Carolina Blood andCancer Care, was founded on a holistic approach to the treatmentof cancer. We constructed the building with a U-shaped designthat allowed all patients to look out onto a healing garden witha gazebo topped by a golden dome. When weather permitted,patients could receive their chemotherapy treatments outside onthe patio or under the dome. It wasnt just for the patients comfort.During difficult discussions, a quick glance at the garden in bloomor the smile of a patient resting in the sun grounded me, put lifein perspective, and reminded me of my mission of service.Patelsclinic was an early adopter of the patient-centered cancer caremodel designed to serve holistic needs of patients, with a focuson palliative care.1 As described previously in EBO, Carolina Bloodand Cancer Care Associates has been one of the most successfulpractices in the country in executing alternative payment models(APMs), which gives practices more support to help patientswith advanced care planning.1,2 But when Patel and Falls were having their conversations years ago, these ideas were still new,and support systems like the one that Patel created for Falls wereharder to find.

The healing garden is the recurring setting where readers ofDying Without Fear will vicariously accompany Falls along hisjourney toward death. Pondering his grim diagnosis, Falls decidesnot to pursue chemotherapy or any other treatments, becausethey would involve diffi cult adverse eff ects and would be unlikelyto prolong his life significantly. After evaluating where I standand how Ive lived all these years, I feel it would be best for me tostart packing my bags for the ultimate and infinite journey. God blessed me with a life that I have noregrets over Lets face it, Doc. From everythingyouve told me, treating my cancer is like trying tosave an exploding plane in mid-air. Chances areits not going to happen. I think of it like Ive justreceived an upgrade on a long fl ight. Ive collectedso many miles that God has granted me a charterflight to a destination unknown. Now the only issueis the waiting time.

Doctors have debated for more than 20 yearson how to engage cancer patients in the decision-making conversation once they have reachedthe terminal stage.3 The culture of care in theUnited States suggests that Falls is an exception,with language around treatment calling onpatients to fight cancer even when it cannot be cured. A 2019 study of 20 women with metastaticbreast cancer found that patients definitionof a good compassionate doctor was one whogives positive news and leaves room for hope.4Another study published last year found that 28%of patients with imminently fatal colorectal cancerreceived treatment , even though this can preventpalliative care.5

Patel writes, Even when I was seeing patientswith very advanced cases where I knew they werebetter off dying peacefully than going through thepains of chemotherapy, which bought them maybe afew more weeks, almost every patient I came acrosswas adamant about hoping for a miracle. But Harrywas different.

Falls decides he will not pursue extraordinarymeasures to avoid death, but he has an extraordinarycuriosity about the dying process, which Patelstrives to appease. Upon receiving his terminaldiagnosis, Falls says, Doc, Im not a religious orritualistic individual. Im somewhere between anon-believer and an agnostic. But I have somefundamental existential queries that are hauntingme. I want to know how death has been definedall these millennia. How do people die? Did ourancestors understand death in a similar fashion toour understanding? How did they treat the bodiesafter death? How was this diff erent across cultures?What about the afterlife? What is a good death, orrather, what does it mean to die well? I can handle amid-air somersault and navigate the worst turbulence.But I am totally incapable of even remotelyimagining my own mortality and afterlife.

Patel responds, I wish everyone facing death,which is in fact everyone someday, would spendtime thinking about these questions.

Patel comes to the conversations with immensecross-cultural knowledge. The reader is drawn in bypoignant stories of a doctor and his terminal cancerpatients, which stimulate Falls discernment abouthow to spend his final days meaningfully, and aboutdisposition of his body after death. For example,Patel introduces the Indian custom of a funeralpyre, and describes how he fulfi lled the traditionalceremonial role of igniting his brothers funeralpyre. He explains beliefs and rituals associated withdeath in ancient Egypt, Greece, Rome, and Australia,and in Hinduism, Buddhism, Judaism, Catholicism,evangelical Christianity, and Islam. He delves intotopics not normally covered in a physicians training,such as the human soul, possibilities for an afterlife,and the meaning of suffering.

Although his cancer is not cured, Falls satisfieshis human need to prepare for a peaceful death.Readers will not want to put the book aside until they learn how Harrys story ends.

Patels purpose for writing Dying WithoutFear, described in an interview with EBO, is toprompt communal and personal preparation for aprofound human experience that is unavoidable,yetparadoxicallytoo seldom a subject of openconversation. Patel thinks humans will have moremeaningful and comfortable experiences of deathif their community does not treat death as a taboosubject, or an event to be delayed through extreme,often painful measures that yield meager improvement in longevity or quality of life. He writes:

I see it every day; patients in their last few daysenduring horrifi cally painful therapies when wehave already informed them that the end resultof that dreadful suff ering will be maybe twoor three more weeks of life spent in agonizingpain. The pain and the therapy do not allowthem to spend time with their loved ones or enjoy the comforts of life. Those few weeks are spentchained to a hospital bed. We are too willing, itseems, to bargain away quality time with thosewe love and freedom from debilitating pain inexchange for fourteen to twenty-one more dayson earth. And in that last leg of the marathon,instead of preparing and planning for a graceful and pain-free departure surrounded by those wehold dearest, we prefer to ruin those last, mostprecious moments in pursuit of a farfetched cure,ensuring that the fi nal days we spend on earthare the most miserable of our entire lives. It isthis fate that, as a physician who has been at thedeathbed of countless numbers of my patients, Iwant to help people avoid.

As Patel shares stories of his deceased patients,its evident that they have benefi ted from a highlyattentive physician. He accepts their calls to hiscell phone at all hours; he visits their homes;he attends their funerals. Readers who havestruggled to schedule appointments with theirphysicians may be astonished at the generosity of the time spent with Falls. Yet, from an ethicalperspective, Dying Without Fear raises serioussystemic concerns about empowering patients toexercise genuine informed consent. How much isinformed consent for end-of-life decisions underminedor impossiblefor countless patientswho begin the dying process as Falls did, but neverhave the opportunities for education and reflectionthat he received?

Read the rest here:
BOOK REVIEW: One Oncologist's Journey With a Patient to the Outcome We All Face - AJMC.com Managed Markets Network

Homo Galacticus: How Space Will Shape The Humans of The Future – ScienceAlert

Human evolution is complicated, to say the least.

It's complicated by love, which makes us want to keep people alive. It's complicated by science and technology, which give us the power to do so. It's complicated, sometimes, by politics. And it's complicated by our environment, which is relatively stable, meaning we haven't needed many significant adaptations for thousands of years.

But what happens when that changes? What would happen to a population of humans - generations of humans - who left Earth to find new lives in the vast wonder of space?

The environment out there, beyond the protective environment of our home planet, is very different from the one we've evolved in for millions of years. It's quite conceivable that our species would become something altogether different.

For decades, this potential transformation of humanity has been fertile ground for speculative fiction.

In James S. A. Corey's wildly popular The Expanse series, and Robert Heinlein's The Moon is a Harsh Mistress, away from the strictures of gravity we see humans evolving to be unnaturally tall, brittle-boned creatures.In Becky Chambers' To Be Taught If Fortunate, we see the reverse - bones thickening on high-mass exoplanets, to support a higher body mass.

We see a lot of longevity as imagined technologies extend our lives. Iain M. Banks' Culture novels are a brilliant example of this, wherein humans develop the ability to live for centuries, and become cosmic dilettantes. In Bruce Sterling's Schismatrix, humans have genetically engineered themselves to such an extent, they're pretty much a new species.

While the specific outcomes and pathways vary quite wildly in science fiction, the concept itself - human metamorphosis away from Earth - isn't that far-fetched. It may not seem like it, but as we go about our day-to-day lives, humans are still evolving.

Scott Solomon, an evolutionary biologist at Rice University, has written a book on the continuing human evolution, and spent a lot of time thinking about how we might evolve in the future. According to him, migrating away from Earth is bound to change us.

"For evolutionary change to occur, you need genetic variation and you need natural selection," he told ScienceAlert.

"When you have those two things for a population that's facing a very big change in environment, evolution can happen quickly. We will have all the pieces in place if we move to, say, Mars."

Environmental pressures are going to be a huge part of our transition from an Earth-bound species to a space-faring one. That's already evident. Just a temporary jaunt in space physically changes people. Astronauts, even after a few months in space, can take years to restore the bone density lost in microgravity. Some changes occur even faster.

Kira Bacal is a medical scientist and practising physician at the University of Auckland in New Zealand. But she spent several years working at NASA's Johnson Space Center working in aerospace medicine.

"There are some things that happen on an extremely rapid timeline," she told ScienceAlert.

There is, for example, the baroreceptor reflex. It regulates our blood pressure, keeping it at a constant level in response to external changes. It's the reason you don't faint when you stand up, keeping your blood from pooling in your feet due to gravity. In microgravity, this reflex is immediately impaired because you don't need it.

Changes also happen in the vestibular system - the finely tuned mechanisms that help us keep our balance and control eye movements, along with the brain processing involved.

"Suddenly you're in a situation where if you drop something from your hand, it doesn't go anywhere," Bacal explained.

"So the whole expectation of what's going to happen, the processing of the sensory inputs you're getting, the way it feels to move through space, no pun intended, is very different."

Other changes that take place over time in microgravity include the loss of bone density; without the constant stress gravity places on your bones, they lose density at about 10 times the rate of osteoporosis. There are also anatomical changes to the eye, microstructural changes in the brain, and even changes in the gut microbiome.

Although these physiological changes give us some idea of the environmental pressures that could shape the evolution of space-faring humans, they only affect individuals to different degrees, and seem to revert to normal when the astronaut returns to Earth, even if it sometimes takes a few years.

So, how fast could we expect to see permanent evolutionary adaptations in Homo galacticus? To understand the timescales involved, terrestrial precedent can help us once again. Two recent examples, detailed inSolomon's book Future Humans, are disease resistance and adaptation to the lower oxygen levels of high altitudes.

In the tropics, where malaria is most common, there's also a higher incidence of sickle cell anaemia. That's because sickle cell, a hereditary disease, involves a gene that protects against malaria - so people most likely to survive malaria and reproduce are also sickle cell carriers. And different populations of people living at high altitudes have developed different adaptations to cope with low oxygen levels.

Both of those are relatively recent, taking place over the last few tens of thousands of years - practically an eyeblink in evolutionary terms.

But it's not just the environment that shapes the path of our evolution. Culture - the way we live and the choices we make - also plays a role, and it can speed things along quite substantially.

"We can see things that have happened even in just the last several hundred years," Solomon said. "For example, quite a few studies have found that the timing of reproduction is evolving in modern human populations, and it's evolving in ways that are often surprising to people."

In the case of the French-Canadian population of le aux Coudres, for instance, detailed church registers dating back to the 18th century showed a curious trend - the average age at which women gave birth to their first child went downfrom 26 to 22 in a 140-year span. This reproductive age seems to be heritable, and women who reproduce younger have more children that also reproduce younger, coming to dominate the population. That's natural selection.

But in other places, that age of first reproduction is rising, as women choose to delay having children for various reasons, now that those regions have readily available means to do so. That's culture - and technology - at work.

"This is a good example of natural selection and culture in society having sort-of tug of war over the same characteristics," Solomon said. "Some people have gone so far as to say that [culture] has replaced natural selection, but I think it's quite clear that it hasn't replaced natural selection, it's just changed it."

Culture, technology and natural selection will be important for space-faring humans, too. Will there be artificial gravity or not? Science fiction puts forward that lack of gravity will result in bird-boned, brittle humans, but Solomon believes otherwise - simply because of the strain childbirth puts on our bones.

Not only is the birthing process hard, but minerals to grow the baby are often taken from the mother's bones, resulting in lower bone density. So the women more likely to survive pregnancy and childbirth in space might have denser bones to start with, allowing them to live to have more dense-boned children. Technology and natural selection could both play a role there.

Will there be radiation shielding? How strong will it be? Because radiation can drive mutation (and cancer), and being exposed to it could produce some unexpected evolutionary pathways. But darker skin is more resistant to dangerous radiation, so that could play a role, too.

These - and other, smaller influences - are all going to have varying effects, sometimes playing tug of war with the same trait to shape a human optimised for their space environment.

By and large, we can't really predict what our space-faring descendants will look like, because we don't know all the factors that are going to come into play.

Even with all those unknowns, decisions made before those pioneers set off into the infinite final frontier - decisions we might see made in our lifetimes, in fact - will have more of an impact than we might know.

As Solomon explains, it's yet another effect we've already watched unfold on Earth - the founder effect.

"The people that are the founders will have a very significant influence on the long-term makeup of the human population in space," he said.

"It plays out on Earth all the time. Every time a new island pops up out of the sea there are going to be some plants and some insects and other species that will eventually make their way there. And whatever characteristics and traits they happen to have are going to be the characteristics that are going to be present in that population."

We can already see hints of how it might play out for spacefaring humans. Earlier this year, NASA put out a call for astronaut applications - and one of the requirements is a Masters degree. That means people who are wealthy enough to be highly educated. That means, in America at least, probably white people.

Not every country has the resources for a human space program, or can train astronauts. Sometimes the decisions on who gets to go to space may be politically motivated.

People can also get selected based on physical traits, which is starting to sound a bit too much like eugenics, if the plan is to travel space for multiple generations.

"A lot of how we develop and what we develop is affected, not so much by 'is there gravity' or 'isn't there gravity', but by who they decide make acceptable astronauts," Bacal said.

A mid-point as a test case, she points out, is the notion of the commercialisation of space. Miners, for instance - spending stretches in low gravity, returning to Earth in between jobs.It takes much longer to regain bone density than it does to lose it, so it could be possible that space miners never gain enough time to fully recover, resulting in early-onset osteoporosis.

"That could - as it already is in terms of the astronaut corps - impact who gets to work there or who gets chosen for your 10-generation generation ship. You might say, 'look, we're going to choose people who are less likely to be susceptible to bone density loss'," she said.

"That has ethnographic implications. It has gender implications." And these will need to be considered very carefully if we want to avoid a situation where specific groups of people are barred from space because of their race or gender.

We may never become a true space-faring species. It's possible we'll never leave the Solar System. But we're also not likely to stay here on Earth forever.

Space agencies are already making plans for at least one permanent base on the Moon. We've sent several robotic missions to Mars, and plans for a crewed mission are underway. A permanent Mars colony isn't out of the question, either.

These are harsh, literally alien environments, with low gravity and intense radiation. They're entirely different from our home planet, where we've been evolving for millions of years. These places will inevitably have an impact on the human body.

So will the technology we have available, how we travel, and the decisions we terrestrial humans make about who gets to go. But not all differences are visible to the eye.

"You know, there are people that are better at coping with radiation here on Earth. You can't tell by looking at them, but they might live longer than the rest," Solomon said.

"I think a lot of the changes are things that will take place inside the body. I think there would be some outward changes, but a lot of more subtle, internal changes."

In the end, those future humans, the inheritors of the stars, may not look as different from us as we might expect.

See more here:
Homo Galacticus: How Space Will Shape The Humans of The Future - ScienceAlert

Grey’s Anatomy’s Kelly McCreary on That Surprise Finale and How Grey Sloan Might Handle COVID-19 – Esquire

After a few moments of chatting, it's clear that Kelly McCreary and the brilliant cardiothoracic surgeon she plays on Grey's Anatomy aren't terribly different. From the moment she answers the phone ahead of this year's season finale, she is warm and friendly. She is the kind of person who uses first names in a way that seems like she's known someone forever. She's also anxious. Seriously. Literally 29 seconds into our discussion, she admits the current COVID-19 pandemic has set her on a bit of an emotional roller coaster.

"Every other day I'm going absolutely nuts inside. One day I can be a little bit productive and focused. The next day, I can be drowning in anxiety and depression," she says with an nervous laugh. McCreary, who joined the series at the end of its 10th season, has a charming candor reminiscent of the emotionally honest characters who define the series on which she stars. In a time when the perils of real medical trauma are scarier than scripted medical trauma, there's something strangely comforting about a Grey's Anatomy doctor being worried, too.

In her onscreen world, McCreary's character, Dr. Maggie Pierce, has had quite a taxing few months herself. Throughout Season 16, tragedy and misfortune have plagued Dr. Pierce's personal and professional lives. The mid-season finale left the fate of Dr. Pierce's career in question after she missed a crucial step in an important surgery. Because of production issues related to COVID-19, the April 9 episode will serve as the season's finale. In the episode, Dr. Pierce has rebounded only to have the fate of her biological father, Dr. Richard Webber, hang in the balance. In short, both McCreary and Pierce could use a break from the insanity.

Jessica Brooks

Although this global pandemic put a rush order on Grey's Anatomy's final episode, Season 16 ends in classic Grey's Anatomy fashionwith a twist and a bang. McCreary spoke with Esquire about the big finish and what's to come for Grey Sloan Memorial.

For this to be a finale the series didn't have in mind for this season, the conclusion was so, so strong. Congratulations on such a successful year.

Well, honestly that was kind of just pure luck. So that was episode 21 out of what was supposed to be 25, but when that episode was produced we had no idea what was coming. We actually wrapped production in the middle of the next episode, so the episode wasn't finished and it was just lucky that [episode] 21 happened to have these elements that wrapped up a storyline and left us with really great juicy cliffhangers. I guess it's just how the writing has been over the course of the entire season. We've been able to take people on these waves again, like these roller coaster rides. We haven't been holding back waiting for mid-season finale and the finale, it's all drama all the time. So we just got kind of lucky.

That's so crazy. It felt so purposefullike a real classic Grey's Anatomy finale.

That's so awesome to hear because obviously they had other plans in the writer's room. I don't even know myself what all was entailed for the finale of this season, but I'm so glad that it's a satisfying story for the audience, that's all I ever want to do is, tell some good stories, so I'm really glad that it feels that way.

I've been so excited for you and your character this season because this is Maggie's sixth full season, I believe.

That's a whole first grader! Maybe even a second grader.

The way that Grey's Anatomy has persisted, there is potential that a current first grader is going to come up to you in 15 years and say, "I've been watching you since I was in first grade," because the show just persists. What is it like to be a part of that?

Sometimes I become aware in these moments... like, there was no social media and streaming and all of that stuff when I was coming up as a kid and in my early professional days, so I couldn't have imagined the longevity. You know how there are some shows that are classics: I Love Lucy and Mash. People still talk about and reflect on [those shows] firmly but it's not as like bequeathed and available for generations of people the way that Grey's Anatomy is. I couldn't have imagined the stickiness of this job. I'm smacked with this idea that for some people I will always be Maggie Pierce forever.

I'm so intrigued by this season because I've been waiting on a season where Maggie really has a reckoning and she's had I feel several in one season, particularly with her medical expertise being questioned.

I definitely think that she is coming out of it stronger with time. Personally, I'm a big believer that every breakdown is an opportunity to have a breakthrough and sometimes it takes stillness and self medicating with television and whatever people need to do to sort of like be able to receive the lesson of the moment, be able to take out the time to figure out what the next great step is.

I think it's only interesting to watch somebody be great at something all the time for so long. Even in your own life, even when you're sort of going along succeeding, everybody looks for ways to be challenged and find a way to grow and see if they can be better. That's been so much fun to play. I love seeing her coming out on the other side of it as a better teammate, even more critically thinking doctor, as a member of this community who can relate to her peers on an even deeper level now.

Is there anything that you hope that Maggie gets a chance to do or encounter that maybe she hasn't yet? Are you looking for your big explosive, oh gosh, what happened to Maggie moment?

This season wasn't enough of a big explosion? [laughs] It was so much fun to shoot the episodes where Maggie's got to have her love at first sight momentthis romantic comedy experience. Maggie is a perfectionist, and I can relate. People who are perfectionists sometimes miss out on being in the moment when they're looking so hard at analyzing the moment. So that was a real thrill. I'm looking forward to seeing whether and how that progresses in the next season.

I have to ask you a silly question, especially in these times. How often do you get solicited for actual medical advice?

Oh God, I don't. But sometimes I give it out for some reason. Like, I don't know what I'm thinking. I've still practiced at speaking with authority about medicine on the show that I am very quick to offer my opinions to friends and some family. Oh no, you can take this supplement and make sure you see your doctor about that. And like, what do I know?

In a different world, how do you think the doctors of Grey's Anatomy would handle the situation we're currently in?

Oh man. I'm sorry, because when you say that, I get this image in my head of all the things I've seen on the news and reports I've read and heard from medical professionals. They're so tired and they're so scared and they're so under resourced and yet they are still pushing through. They're isolated from their families sometimes. I think about the sacrifice that they're making and it literally goes through to my eyes every single time.

I like to think that the doctors of Grey Sloan Memorial would be like them, and the doctors at Grey Sloan are also for some reason all total prodigies at solving major problems. So hopefully they'd be able to figure out the problem of the resources and come up with some inventions that could help. Use the might of the Catherine Fox Award and the wealth at that hospital to find a vaccine.

I would hope that they would be leading the charge for this, but at the very least, I would hope that they would be as good as the people who are out there in New York City and Michigan and all these places where it's so scary and unrelenting right now.

Read more:
Grey's Anatomy's Kelly McCreary on That Surprise Finale and How Grey Sloan Might Handle COVID-19 - Esquire

Camus, New York and unending wars of pandemics – Daily Sabah

The pictures of the empty streets in New York City taken during the coronavirus crisis gave a strange feeling to everybody. For those who saw or experienced the traffic jams on the main avenues of the city and the crowdedness of Times Square, the photos were unfamiliar. An odd and bizarre sense of emptiness, a peculiar atmosphere of desolation and at the same time a perplexing and puzzling beauty made millions view these pictures again and again.

In fact, this unusual scene of abandoned New York streets has been in several different movies. It was always as a background for an eerie, ghostly, mysterious or dreamy situation. In the movie "The Devils Advocate" (1997), one of the most suspenseful scenes was Kevin Lomax (Keanu Reeves) walking on the deserted East 57th street, to confront John Milton (Al Pacino). In another movie "Vanilla Sky" (2001), this time David Aames (Tom Cruise) was driving his car from uptown Central Park West to Times Square, seeing the streets and Times Square totally empty. It was a dream, a nightmare to be more precise. In both movies the protagonists were shocked and confused to see the emptiness of the streets in New York. It was unusual not only for these two protagonists who had their offices in the busiest parts of Manhattan. For the millions of viewers of these movies as well, it was a sign of abnormality, irregularity and oddity. New York City has always been identified with its chaos, complexity, crowds and orderly disorder.

In the last few weeks, we have seen a sufficient number of these pictures and photos which satisfied our awe and made many around the world feel somehow blue, gloomy and melancholic. The scenes that we used to see in fiction scenarios have become real. It has been happening in the midst of a pandemic and outbreak of the coronavirus. This added another layer of unusualness to the situation. For Hollywood producers, New York has always been a primary target for the outside forces who would harm humanity. In "Independence Day" (1996) aliens in a giant spaceship attacked the city. In "Deep Impact" (1998) it was a meteor that generated major tidal waves that destroyed the city. In "The Day After Tomorrow" (2004) New York had become a victim of global warming. Even the monsters, including "King Kong" (2005) and "Godzilla" (1998) targeted the city. This time the city was attacked by invisible viruses and for real.

New epicenter

The epicenter of the coronavirus is not Wuhan or Milan anymore, for the last two weeks New York City is considered the real hot spot of the deadly outbreak. The urgency of the situation is obvious from, now regular, press conferences of the governor of New York state and the mayor of New York City. Gov. Mark Cuomos press conferences have been followed all around the world by people who want to understand the true extent of this pandemic. As of today more than 180,000 people in New York are infected with the deadly virus and 9,000 people lost their lives, almost three times the casualties of the 9/11 attack.

Nineteen years after the horrible terrorist attacks aimed at the World Trade Center, we have seen New York as the center of the worst pandemic of the last several decades. The scenes from the overcrowded hospitals and mortuaries are circulating all around the world. The burial of the unclaimed bodies of pandemic victims to Hart Island in New York gave chills to millions of people. The Big Apple, the finance capital of the world, that hosts the United Nations, the biggest corporations, the most expensive real estate and the most magnificent museums in its territory during this crisis showed the frailty of human lives and limitations of technology and medicine to fight against some small viruses.

The outbreak of the virus in the city now reminds many people of the beginning of the crisis in the city of Oran from Albert Camuss "The Plague," which has become one of the best sellers again 73 years after its publication during the days of the coronavirus. In the novel, first the dead rats in the streets and then an increasing number of people with fevers in the hospitals signaled the emergence of something unusual. There was always a fear of a plague but nobody, including the leading character of the novel Dr. Rieux was willing to admit the true nature of the threat the city was facing.

The novel raised the issue of how people failed to really prepare for a threat such as a plague. Each and every time it is considered as a surprise, something like an earthquake. In a memorable quote of the novel, it was stated that "'Everybody knows that pestilences have a way of recurring in the world; yet somehow we find it hard to believe in ones that crash down on our heads from a blue sky. There have been as many plagues as wars in history; yet always plagues and wars take people equally by surprise. In New York, the situation was not that different. This time the warnings and red flags were not coming from the history books or the stories of the elder residences of the town. According to the experts, the spread of the coronavirus first throughout Asia, then throughout Europe raised the risk of a potential outbreak in the U.S. in the coming weeks. The most likely target was, of course, the most significant and cosmopolitan city of the U.S. But again everybody, including New Yorkers, took it as a surprise when in March the virus shocked people with the speed of its spread.

Some of the administrators of New York were not different from the high level bureaucrats of Oran. They knew what could go wrong during the epidemic, but it was impractical to alarm everybody. In Oran there was a reluctance to call it a plague, and administrators took draconian measures. In New York, it was already known that it would be a host of the coronavirus outbreak, but the problem was how to take action against it. The mayor of New York was among the people who did not want to seem alarmed. Mayor Don DeBlasio asked New Yorkers to go about their lives and to go about their businesses in the midst of the outbreak in the world. He said that one cannot get this virus in a subway or stadium or in a conference. He claimed that if someone is under 50 and did not have an underlying medical condition it will not be a major threat. He seemed to be very much against the school closures in the city. It turned out that the motivation of the administrators have always been more or less the same, a) fear of a false alarm b) a desire to avoid disruption to everyday life of citizens and c) to provide the continuation of economic and social activity in the city. In Oran people believed that these forms of epidemics were just like bad dreams that will pass away; in New York the expectation of many was that it can be managed and it would go away like a regular cold for many people. President Donald Trump, for instance, a New Yorker himself, believed that it would miraculously go away.

But it was not only the administrators, citizens also made similar mistakes during the beginning of the outbreak in both Oran and New York. The narrator in the novel explains how the residents of Oran failed to take precautions despite warnings. Thus the blame fell on them as well. According to him, they forgot to be modest... and thought that everything was still possible for them, which presupposed that pestilences were impossible. They went on doing business, arranged for journeys and formed views. How should they have given a thought to anything like plague, which rules out any future, cancels journeys, silences the exchange of views. They fancied themselves free... Following the stay at home order issued there were pictures of New York parks and streets on social media with a lot of people continuing with their routine. Cuomo had to warn people multiple times about the danger that this behavior poses for New Yorkers.

In a press conference he warned young people by saying that "'So you're not Superman and you're not Superwoman; you can get this virus. And you can transfer the virus and you can wind up hurting someone who you love or hurting someone wholly inadvertently. This is a public health issue and you cannot endanger other people's health." Later his tone got tougher when he saw the continuing presence of the people on the streets. This time he called the crowds wholly inappropriate and stated that its insensitive, its arrogant, its self-destructive, its disrespectful to other people, and it has to stop, and it has to stop now and added that it is not a joke and he is not kidding. "He reminded New Yorkers that this is not life as usual. It took this much warning and thousands in the hospitals overcrowding the wards and ICU units for New Yorkers to understand the extent of this threat.

It is sad. It is unprecedented for many people in this generation to see a pandemic causing this much damage to a city and its residents. It is sometimes inconceivable to understand how an epidemic cannot be contained even by the most advanced nations. It is sometimes hard to believe the amount of harm that a virus can give to societies and economies around the world. For a moment or for years we have believed that pandemics were something that belong to history textbooks. We woke up with the coronavirus. The residents of Oran and New York and indeed the people in the world need to understand the fact that the epidemics will be around for a long time. There will be fighting, there will be casualties. Epidemics and pandemics have been the part of lives of many generations and it seems that it will continue to be that way. The number of casualties, the longevity of the battle and the nature of fighting will depend on the level of preparedness of humankind for these kind of diseases. As the narrator of the novel stated about the end of the plague in Oran, there will not be a definitive victory. It will just be the end of another battle. The virus, just like the pandemic in "The Plague" will stay dormant, until it rises again.

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Camus, New York and unending wars of pandemics - Daily Sabah

Eating healthy more important than ever now – NewmarketToday.ca

Dear Nonie,

Thank you for the recipes last week! Im interested to know what is understood up till now about treating coronavirus holistically. Suzanne from East Gwillimbury

Dear Suzanne,

I wrote an article on March 15 about boosting immunity holistically for coronavirus preparedness and I would first like to point you to that.

The answer to your query is tricky. We dont have studies on natural therapies, except high dose IV vitamin C, as of yet. You can read more about the therapy here. The protocol is based on similar treatments in people with the coronavirus in Shanghai, China, where The patients who received Vitamin C did significantly better than those who did not get vitamin C, according to the lead physician, Dr. Andrew G. Weber (pulmonologist and critical care specialist). Dr. Weber went on to say, It helps a tremendous amount, but it is not highlighted because its not a sexy drug. Corroborating reports on the vitamin C therapy can be found in The New York Times and The Dr. Wrath Health Foundation.

Readers may not know this is actually orthomolecular medicine. The term was coined by Linus Pauling. Pauling was an American chemist, biochemist, peace activist, and more. He theorized about the importance of vitamin C in high doses for optimal human health. The megavitamin therapy was taken up and developed clinically by Canadas Dr. Abram Hoffer (biochemist, physician, psychiatrist). Dr. Hoffer is the person who first introduced me to nutrition and vitamin therapies for mental health conditions. Those interested can read more about orthomolecular medicine here.

The problem with finding data on holistic therapies for COVID-19 is twofold: the virus is new and the current structure of the medical establishment does not support research for the sake of research as well as it should. I am sure I dont need to tell you, medicine is business in todays economy.

A common denominator in cases of mortality from COVID-19 to date is the presence of pre-existing, serious health conditions, of which diabetes / insulin resistance are preeminent. There seems to be a twofold increase in the number of patients in intensive care having diabetes and mortality seems to be threefold higher in people with diabetes, according to data out of China (1). According to CDC coronavirus reports, patients with type II diabetes and metabolic syndrome may have up to 10x greater risk of death from COVID-19 (2).

Insulin resistance explains both metabolic syndrome and diabetes II and it can present clinically even in the absence of type II diabetes. The symptoms are:

A diagnosis of type II diabetes happens after this disease state has progressed quite far, so a number of people without the actual diagnosis may also be at greater risk, which may lead some naysayers to claim the correlation isnt that high, but it is. And, as you can see, this would explain why the elderly are so hard hit by this virus, since these diagnoses are themselves epidemic in the elderly.

Type II diabetes and metabolic syndrome are caused by a diet high in processed foods and carbohydrates and can be managed and even reversed in many cases, by simple dietary interventions and nutrition education.

So if you want to know how to protect yourself from COVID-19, my best advice is first and foremost to take this time to create healthier dietary habits. These habits will help you not just with COVID-19 risk management but in creating better health outcomes overall. And what else can you do with your time at home that will so change the trajectory of your health and longevity?

Ill continue this next week by sharing the top 10 foods that cause insulin resistance and the 10 substitutes you can use to avoid them. If you want to learn even more and take this opportunity to learn how to turn your health around, Im offering a variety of live cooking and nutrition classes every week during the lockdown. You can read more and sign at hopenotdope.ca/events.

Namaste!

Nonie Nutritionista

This article is intended for information purposes only and should not be considered medical advice, for which you should see a licensed medical practitioner. Follow all ministry of health and government guidelines for the appropriate ways to handle COVID-19.

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Eating healthy more important than ever now - NewmarketToday.ca

NIH recruiting 10K adults for coronavirus infection study – ModernHealthcare.com

NEW YORK The National Institutes of Health have started recruiting for a new study that aims to determine how many adults in the U.S. who have not had a confirmed infection with SARS-CoV-2 carry antibodies to the virus, indicating that they were previously infected.

The study, called "SARS-CoV-2 Pandemic Serosurvey and Blood Sampling," is conducted by the National Institute of Allergy and Infectious Diseases and the National Institute of Biomedical Imaging and Bioengineering, with additional support from the National Center for Advancing Translational Sciences and the National Cancer Institute. The researchers plan to collect and analyze blood samples from up to 10,000 volunteers.

"This study will give us a clearer picture of the true magnitude of the COVID-19 pandemic in the United States by telling us how many people in different communities have been infected without knowing it, because they had a very mild, undocumented illness or did not access testing while they were sick," said NIAID Director Anthony Fauci in a statement. "These crucial data will help us measure the impact of our public health efforts now and guide our COIVD-19 response moving forward."

The investigators plan to analyze blood samples for two types of antibodies, anti-SARS-CoV-2 S protein IgG and IgM, using an enzyme-linked immunosorbent assay (ELISA) developed at NIAID and NIBIB. Participants with positive test results may undergo additional tests to evaluate their immune response to the virus. The results may explain why these cases were less severe than those that resulted in hospitalization.

Healthy adults over the age of 18 from across the US who have no confirmed history of COVID-19 and have no current symptoms are eligible to participate and will be enrolled over the phone.

Study participants working at the NIH Bethesda campus will have their blood drawn at the NIH Clinical Center, while other volunteers will take their own blood samples at home, using at-home blood collection kits provided by Neoteryx, a medical device firm based in Torrance, California.

"Researchers have considerable experience using these at-home blood collection kits to track the spread of other infectious diseases like influenza, and this method is safe, effective and easy-to-use," said Kaitlyn Sadtler, study lead for laboratory testing and chief of NIBIB's section for immunoengineering, in a statement.

More information about the study is available here.

This article was originally published in our sister publication Genomeweb.

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NIH recruiting 10K adults for coronavirus infection study - ModernHealthcare.com

University of Maryland lab supplies donated to local hospitals – WTOP

Two University of Maryland students noticed that there were a lot of useful items in local labs that could be used for health care workers fighting coronavirus.

Two University of Maryland students noticed that there were a lot of useful items in local labs that could be used for health care workers fighting coronavirus, and decided to do something about it.

We do have some of this equipment so it only made sense just to get it to the right places that need it immediately, said Christina Conrad, a Ph.D. student in the Department of Bioengineering at the University of Maryland.

Conrad, along with fellow student James Shamul, sent an email to their department to see if there were items in their labs that could be donated to those caring for patients during the coronavirus outbreak.

Conrad said the response was overwhelming.

From there, we started reaching out to the entire university.

Thirty-seven different labs including animal science, biology, physics and other departments replied and donated more than 24,000 pairs of gloves, 2,500 face masks, 137 disposable lab coats, more than 100 N95 masks, and multiple gallons of cleaning supplies.

Its been really just exciting to get a lot of generosity. A lot of people have come together, Conrad said.

They have donated the supplies to the Prince Georges County Heath Department, the University of Maryland Medical Center, Johns Hopkins and the Greater Baltimore Medical Center.

Its definitely a great way for me to spend my time right now since our labs are closed at Maryland, Conrad said. A lot of us Ph.D. students are focused on writing our dissertations or reading literature, so this has just been a really great activity to be involved and try to make a difference.

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How universities are developing COVID-19 solutions in real time – PBS NewsHour

Dorms are empty and classroom lights are off at the vast majority of Americas colleges and universities, but that hasnt stopped many in academia from jumping in to help try to meet the massive need for innovative treatments, vaccines, personal protection equipment (PPE) and medical devices in the wake of the novel coronavirus pandemic.

Engineers, doctors, scientists, researchers, doctors, and college students across the country have quickly shifted gears and are applying their skills and knowledge to fighting the virus, which has infected more than a million people around the globe. The federal government and most states with stay-at-home orders have designated researchers focused on the outbreak as essential critical infrastructure workers, allowing them to continue working in labs and offices.

A number of schools, including Rice University, the University of Texas, the University of Illinois, and the University of Vermont, have been working on new ventilator designs, a critical need with shortages at many hospitals around the country. Faculty from the University of South Carolina, in collaboration with the medical nonprofit Prisma Health, developed an FDA-approved 3D- printed splitter device called the VESper that can treat two patients on one ventilator. And a team at University of California, Berkeley has modified sleep apnea machines so they can provide respiratory support for noncritical COVID-19 patients.

Given the rapid pace of innovation and, in some cases, the short time from inventors bench to hospital room, ensuring that devices are safe and reliable is a key issue for those on the front lines.

Researchers at academic institutions, non-traditional manufacturers, communities of makers, and individuals are banding together to support and fill local and national needs, an FDA spokesperson wrote in a statement to the PBS NewsHour. The goal [of the FDA] is to enable and empower people to make a positive impact in the ways they are able, while ensuring their efforts and outputs are safe.

The FDAs Center for Devices and Radiological Health the government agency tasked with regulating firms who manufacture medical devices sold in the U.S. is using Emergency Use Authorizations (EUAs) to determine if it is reasonable to believe that the [products] may be effective and that the known and potential benefits outweigh the known and potential risks. The FDA declined to disclose the number of EUA requests it has received in response to the COVID-19.

Here are three more ways universities are contributing to the global virus response.

In the dash to prevent needless deaths, some scientists have postponed or abandoned long-term projects to engage in new coronavirus work. Others, like Matt Whitehill, who is pursuing a doctorate at the University of Washington, have sped up existing projects that might eventually prove helpful. Whitehill and a team of fellow computer scientists and electrical engineering students, along with collaborators at Seattle Childrens Hospital and U.W. Medical Center, are working on a cough-detection app for smart mobile devices.

Photo by Getty Images

Cough-detection research at UW began in 2011. Different teams have chased the technology over the years, but Whitehill says there is now a sense of urgency to deploy it. The COVID-19 outbreak has really expedited some of our timelines because there is such a large need for this technology, Whitehill said.

The goal of the technology, part of a move toward remote patient monitoring (RPM) in health care, is to assist both patients and their medical providers monitor coughing while someone is recovering at home from COVID-19 or other diseases that cause coughing symptoms. The app relies on an algorithm Whitehill and his colleagues developed that can detect cough sounds amid other background noises such as conversations; those coughs are then recorded in the app or the device, and can be kept private or shared with others, including health care providers.

Whitehill says as health care facilities become overwhelmed, some patients are being sent home who would normally recover in the hospital. Health care providers or community organizations may want to have some insight into how those patients are doing when they go home, Whitehill said. Automated remote monitoring allows us to get an insight into whether that patients health condition is improving or deteriorating in an objectively reliable, real time way without needing to make contact with the subjects.

Other groups are also working on cough-detecting technology, but Whitehill says UWs app is unique because its aimed at providing a high level of accuracy and protecting user privacy. Only cough counts are recorded and the data is analyzed on the phone instead of a remote server. The research team is currently seeking volunteers to help improve the app by submitting cough sounds and other vocalizations.

The technology can only monitor cough counts, but Whitehill says eventually he hopes to be able to discriminate between cough types e.g. wet or dry. Because COVID-19 is associated with a dry cough, that kind of information could potentially help health care providers more accurately monitor the condition of COVID-19 patients.

Universities are also joining a number of companies and individual volunteers around the country who are developing new solutions for creating and ramping up production of PPE. Northwestern University, MIT, University of the New Hampshire and Michigan State University are among a number of schools that have started 3D-printed face shield projects.

Stanford University bioengineering associate professor Manu Prakash, whose work has long-focused on innovative, low-cost medical devices, is taking a different approach. In early March, he returned from a trip to Europe, where, he said, he had seen how the coronavirus was taking a toll. Prakash then started an open source project to modify full-face snorkel masks into reusable PPE for health care workers.

Courtesy PrakashLab/Stanford

I was highly concerned about what was going to happen in the PPE context in the U.S., Prakash said. I love diving and I have had a snorkel mask for a long while. So that was the starting point.

Working with a number of collaborators, including Boston Scientific, Medtronics and the University of Utah, Prakashs team developed a 3D-printed filter and injection molded attachment that can be connected to the masks air-intake tube, which is aimed back and away from the face. In their initial design, the team used FDA-approved medical-grade filters that are used in various applications around hospitals but not currently for PPE; recently theyve begun testing other types of filtration systems, including HEPA filters used for industrial purposes.

Prakash says the design, which incorporates a face shield and a respirator in one device, could be helpful to health care workers who typically use separate face shields and masks, if the supplies are available. Face mask shortages have become a widespread problem for health care workers around the country.

Its a very technical challenge because youre talking about [containing] aerosolized droplets that are 300 nanometers (0.3 microns) or smaller, said Prakash, referring to the imperceptible spray of saliva that can come out of someones mouth or nose. Frugal science in this context is about coming up with ways to do things quickly, but still having the highest level of safety standards. You have to be extremely serious about really looking critically at the sets of solutions.

Everyone has a shot of making a contribution, and universities are often where it starts.

In addition to cost, one of the key goals of the project is to ensure the modified snorkel-masks can be reused multiple times safely. Prakash says in the past, more medical products, like elastomeric respirators, were made to be reused over and over again with proper cleaning and decontamination. But our disposable culture has led to more single-use products like N95 masks, and now medical professionals are confronted with the fact that there just arent enough disposable supplies to go around.

The research team has been submerging the masks in solutions of bleach and exposing them to heat, among other approved sterilization methods. Prakash says testing has shown the masks survive common decontamination protocols.

The masks, which have been submitted to the FDA for emergency use authorization, are currently undergoing clinical testing in three hospitals. The team is also shipping 100 more to clinicians for pilot testing and another 1,000 to health care workers around the country who are in urgent need.

The innovation that arguably could have the largest influence on the global COVID-19 response is the development of a vaccine. Of the nearly 80 vaccine candidates now in the works, most are being developed from pharmaceutical companies in the U.S. and abroad. But researchers in academia are also involved in the effort, often building on previous vaccine research. Thats the case for a team at the University of Pittsburgh School of Medicine that worked on vaccines for SARS in 2003 and MERS in 2014; both viruses are closely related to the current coronavirus. Earlier this month, they announced an early-stage vaccine candidate called PittCoVacc in a peer-reviewed paper published by The Lancet. The team is also testing an innovative delivery system for that vaccine: a small patch made with 400 tiny needles made out of dissolvable sugars which are saturated with the vaccine.

Andrea Gambotto, M.D., associate professor of surgery at Pitt, holds a COVID-19 microneedle array vaccine on his fingertip. The 400 tiny antigen-tipped needles poke into the skin to stimulate antibody generation. Photo by UPMC

Dr. Louis Falo, who developed the patch, says one of the benefits of the technology is it doesnt have to be refrigerated. Most vaccines have to be refrigerated from when theyre made, all the way until they are in the patient, Falo said. For underdeveloped countries and global vaccination programs, thats an obstacle. Its really expensive and some places arent even equipped with refrigeration. The patches are very stable at room temperature and I think thats a big plus.

Harvard University public health professor Dr. Barry Bloom, who is not involved in current vaccine research but has been tracking developments, cautions against latching on to any one vaccine candidate or delivery system at this point.

But he says increased collaboration and the speed at which results are now being shared in the scientific world is unprecedented. The diversity of vaccine candidates and other innovations is really exciting, said Dr. Bloom. Everyone has a shot of making a contribution, and universities are often where it starts.

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How universities are developing COVID-19 solutions in real time - PBS NewsHour

Coronavirus: Antibody study on 10,000 people, how many were infected – Business Insider – Business Insider

The National Institutes of Health is enrolling up to 10,000 healthy people in a study that seeks to determine how many people have immunity to the novel coronavirus.

Investigators will take blood from participants and test it for antibodies the body produces to fight off infection. The idea is to figure out the true number of people who've been exposed to the virus, whether or not they had symptoms.

The study is one of many public and private efforts to expand "serology" or immunity tests in the US. Since the tests can measure a response to the virus long after it's occurred, they've been called the next frontier of coronavirus screening and should help the NIH understand the extent of its spread.

Read more: Tests that can tell if you're immune to the coronavirus are on the way. Here are the companies racing to bring them to the US healthcare system.

Led by researchers at the National Institute of Allergy and Infectious Diseases and the National Institute of Biomedical Imaging and Bioengineering, the rollout is one of the biggest serology efforts at the federal level thus far.

"This study will give us a clearer picture of the true magnitude of the COVID-19 pandemic in the United States by telling us how many people in different communities have been infected without knowing it, because they had a very mild, undocumented illness or did not access testing while they were sick," said Anthony S. Fauci, a key member of President Donald Trump's coronavirus task force and the director of NIAID, in a press release.

Whereas reporting of confirmed cases in the US has mostly relied on molecular tests that determine the active presence of the virus in a person's airways, NIH investigators will analyze the blood for two kinds of antibodies indicating prior exposure, proteins called IgM and IgG.

The former develops quickly and typically lasts for a week or two. The latter has a longer life and is involved in the body's secondary immune response, according to the NIH.

"An antibody test is looking back into the immune system's history with a rearview mirror," said Matthew J. Memoli, the study's principal investigator.

Volunteers near Washington, DC will give blood in-person at the NIH campus in Maryland. The NIH will ship kits made by medical device company Neoteryx to other participants for at-home use.

Never miss out on healthcare news. Subscribe to Dispensed, Business Insider's weekly newsletter on pharma, biotech, and healthcare.

The study is not open to people with current coronavirus symptoms or those with laboratory-confirmed histories of the virus. People who suspect they recovered without tests or never had symptoms consistent with the virus in the first place are encouraged to enroll, however.

People interested in joining can contact the NIH at clinicalstudiesunit@nih.gov and will be asked to consent over the phone. Enrollees can request their results after a prolonged waiting period of weeks or months, according to the NIH.

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Coronavirus: Antibody study on 10,000 people, how many were infected - Business Insider - Business Insider

The Heat: COVID-19 and the race for a vaccine – CGTN America

Published April 10, 2020 at 12:31 PM

As the world struggles to contain the coronavirus, we begin with encouraging news from the United Kingdom. British Prime Minister Boris Johnson is reported to be out of intensive care at St. Thomas hospital where hes been cared for since Monday. A spokesperson from Downing Street said the prime minister is back on a ward where hes being closely monitored. The death toll continues to rise in the United States with more than 16, 000 deaths. The epicenter, New York state, reported its single worst day on Wednesday with 799 deaths. And, 6.6 million Americans filed for unemployment benefits, bringing the total number of claims to more than 16 million. Economists say the US unemployment rate is now 13%, the worst since the Great Depression.

CGTNs White House Correspondent Nathan King reports.

To discuss the impact of the coronavirus in the United States:

As the death toll rises from the coronavirus, scientists around the world are racing to find a vaccine that will protect people from getting sick.

To discuss this:

Related

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The Heat: COVID-19 and the race for a vaccine - CGTN America

DRDO at the forefront of fighting Covid-19 – – Defence Aviation Post

In a bid to fight against the deadly coronavirus pandemic, the DRDO (Defence Research and Development Organisation), using its scientific endeavour, has developed a host of protective equipment, ventilators and sanitisation equipment for helping the frontline workers.

The DRDO has developed 11 such products to combat the coronavirus. These products include visor-based full-face shield, isolation shelter, mobile area sanitisation system, advanced N99 masks, personal sanitisation equipment, portable backpack area sanitisation equipment, advanced PPEs (Personal Protection Equipment) for doctors and frontline health workers, ventilators and sanitisers.

With an anticipation of a growing need for ventilators in the coming days for patients fighting the coronavirus, the DRDOs Defence Bioengineering and Electromedical Laboratory in Bangalore, in partnership with Bharat Electronics Limited (BEL) and Scanray Pvt Ltd in Mysuru, will develop modern and portable ventilators at the earliest.

And, according to sources in the DRDO, works on the development of such ventilators are progressing and each scientist and technician is working to come up with the best and most advanced form of ventilator. Apart from this, a personal sanitisation equipment which is a full body disinfection chamber has been developed by the DRDOs Vehicle Research and Development Establishment laboratory in Ahmednagar. This personal sanitisation equipment, which is currently being used at the entrance of many markets across the country, is a walk-through full body disinfection chamber. It is a portable system equipped with sanitiser and soap dispenser.

The decontamination is started using a foot pedal at the entry. On entering the chamber, an electrically operated pump creates a disinfectant mist of hypo sodium chloride for disinfecting. The mist spray is calibrated for an operation of 25 seconds and stops automatically, indicating completion of operation.

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DRDO at the forefront of fighting Covid-19 - - Defence Aviation Post

Community Connections: Midland Public Schools reflects on a memorable school year – Midland Daily News

Dow High School The Charge Robotics Team Adopt-a-Street. (Photo provided)

Dow High School The Charge Robotics Team Adopt-a-Street. (Photo provided)

Dow High School The Charge Robotics Team Adopt-a-Street. (Photo provided)

Dow High School The Charge Robotics Team Adopt-a-Street. (Photo provided)

Community Connections:Midland Public Schools reflects on a memorable school year

With our world, nation, state and community consumed by COVID-19 these days, Midland Public Schools would like to take a step back to celebrate and honor our students, staff and district's incredible accomplishments during the 2019-20 school year.

Our in-building school year may have had to end a few months early, however, the honors and accolades we celebrate in this month's Community Connections speak volumes about the quality, dedication, hard work and support of our students, staff and families. While the following successes are lengthy, please know there are so many more!

MPS named one of the Best 20 School Districts in the State by Niche in 2019 (out of 556 districts), putting MPS in the top 4% of public school districts in the State of Michigan.

25% of the 2020 Michigan winners in the annual Aspirations Award from the National Center for Women in Information Technology were from MPS High Schools (8 MPS students were Aspirations in Computing winners; 2 received Rising Star Awards; 6 received Honorable Mention).

58 MPS 2019 graduates and current seniors earned the Michigan Seal of Biliteracy for demonstrating proficiency in English and at least one other world language before they graduated.

44 Midland High Business Professionals of America members earned the right to compete at this year's state leadership conference.

79 HH Dow High DECA members qualified to compete against their peers from around Michigan DECA State Career Development Conference. They brought home 66 medals and 21 students qualified to compete at the international conference. Senior Kamika Chandra, was the recipient of the 2020 DECA Emerging Leader Honor Award.

Dow High's Debate Team earned the distinction of Varsity State Champions.

Midland High placed No. 1 at the Michigan State University High School Programming Competition.

This year, as they do year after year, MPS teams, student athletes and coaches earned many SVL and Michigan High School Coaches Association awards and accolades

Midland High Seniors Corbin Dittenber, Timmy Kipfmiller, Erika Leasher and Andrew Scheffer won the 2019 Congressional App Challenge for the 4th District for their "Meal Deals" app.

HH Dow High's Science Olympiad team competed at Delta College and took home six first place medals, two for second place and four for third place.

Jefferson and Northeast Middle Schools dominated the Regional Science Olympiad Competition at Delta College earning medals in 18 of the 22 events. Jefferson placed first and Northeast placed a very close second. Both teams qualified for the Science Olympiad State Meet.

Jefferson Middle School's regional qualifying team competed at SVSU against 11 other area schools in the State of Michigan Challenger for You Be The Chemist Program sponsored by Dow Chemical. The Jefferson Husky team took 2nd place and advanced to the National Level!

The Dow High Math Club earned first place at the Math Field Day Competition at U of M Flint.

800 MPS student musicians participated in the MSBOA Band and Orchestra Festival. Every MPS band and orchestra that attended earned a 1st division rating overall with most ensembles earning 1st division ratings from every judge.

Midland High Junior Izaac Goergen competed against 59 Division 1 bowlers to become Midland High's first Boys' Bowling State Champion!

Nine MHS Welding students competed at Skills USA's Regional Welding Competition. Aaron Clark won first and qualified for States. In addition, six welding students traveled to the Industrial Arts Institute in Onaway for their annual welding competition. Abby Markel was officially the first girl to ever place at that competition, earning second place in Gas Metal Arc Welding from among the 85 who participated.

The Adams Elementary Book Warrior team won this year's annual Battle of the Books sponsored by the Grace A. Dow Memorial Library.

Elementary FIRST Robotics: 26 FIRST Lego League Jr. teams (grade 1-3); nine FIRST Lego League teams (Grade 4-5). All six MPS elementary schools had FIRST robotics teams. Three FIRST Lego League Teams earned the right to compete at the MI State Championship: Siebert Bulldog Builders, Woodcrest Cyclone Wolverines, Adams City Warriors.

Middle School FIRST Robotics: All five MPS FIRST Tech Challenge Robotics teams (grade 6-8) qualified to compete at the MI State Championship!

High School FIRST Robotics: Two award-winning Robotics teams: Dow High's Team is 2209 'The Charge' and Midland High's Team is 5509 'Like a Boss' -- this competitive season may have been cut short for our high school teams, but both teams planned, built, troubleshooted, programmed and competed as knowledgeable, organized, collaborative, supportive teams. The MHS 'Like A Boss' team competed at Kettering University and won the Spirit Award; DHS 'The Charge' competed at the St. Joseph FIRST Robotics Competition and won the Gracious Professionalism Award.

FIRST Robotics Dean's List Award Semi Finalists were named: Midland High's Moira Blanchard and Ben Miller; HH Dow High's Caleb Allington and David Watkins

A major focus for MPS is Diversity, Equity & Inclusion (DEI). Here are just a few ways MPS focused on DEI:

Midland Public Schools hosted exciting unified football and basketball games in 2019-20. In these Unified Interscholastic Games, special education and general education players took the field/court before the Varsity Games to compete with the same rules as the high school football/basketball games. Hundreds of students and adults cheered on the Unified Teams giving everyone on the field and in attendance wonderful memories.

Midland High held a One Billion Rising event that discussed how we can be "upstanders" rather than bystanders regarding gender violence.

Chestnut Hill held a Multi-Cultural Night that presented information to over 165 students on 15 different countries/cultures.

First Graders at Central Park took part in an International Day experience that led them on a journey to Israel, Spain, Nepal, Botswana and China. Students learned about cultural customs and traditions.

Another major focus for MPS is kindness through our #keepitkindMPS initiative. MPS students "keep it kind" in many ways. One way is through their volunteerism and giving back to our community. Here are just a few amazing examples:

Midland High's SAVE Club students promote kindness District-wide by reading to over 35 MPS Kindergarten through Grade 2 elementary school classrooms.

HH Dow High's Girls' Varsity Basketball team volunteered at Woodcrest Elementary on the day of all of their home games this season reading books, playing with students during recess, helping with math & more.

Students at Siebert volunteered at the Open Door.

Students at Woodcrest Elementary made blankets and donated them to Mid-Michigan Medical Center.

Midland High Music Department students gave a community member a helping hand by doing some fall yardwork

Many schools organized ingatherings such as socks, toys, stuffed animals, food, personal care items, etc. for area non-profit groups.

Siebert Elementary fourth and fifth graders created kindness coins in their art class to give away across the community. Their goal: to spread smiles far and wide and to share kindness to make the world a better place.

Jefferson Student Leadership organized after-school blanket making parties where Huskies came together to make fleece tie-blankets that they donated to Shelter House.

HH Dow High's Robotics Team sponsors an "Adopt-a-Street" section of Patrick Road helping to keep Midland beautiful.

MPS educators continue to be asked to present at state and national conferences as well as receive awards and accolades in their own right:

Diane White, DHS computer science teacher, and Robert Fox, MHS computer science teacher, were awarded the Inspiring Teacher Award by the Women in Engineering Society and Michigan State University.

Lynn Verdusco, Woodcrest Elementary teacher, and Andrea Jozwiak, Midland High business teacher/interim assistant principal, have been chosen to receive a Heroes in Education Award by SVSU.

Jen Lenon, MPS Middle School learning coach, was chosen as a Regional STEM Star by SVSU.

Jillian Seamster, Central Park third grade teacher, and Amanda Brown, Northeast sixth grade social studies and reading teacher, were chosen as Outstanding Teachers of the Year by the Saginaw Spirit.

Lynn Heil, Spanish teacher at Jefferson Middle School, was selected to speak at the World Language National Conference in Washington, D.C. with attendees from all over the world.

MPS world language teachers Patti Borus, Amy Rankin and Brian Smith were invited to present at the Michigan World Language Association annual conference in Lansing.

As you can see by the many accolades listed here, MPS students, staff and coaches represented Midland Public Schools and the Midland community in so many varied and competitive ways throughout the state of Michigan and beyond during the 2019-20 school year. Kudos MPS students, staff, coaches and parents for your hard work, preparation, professionalism and support in the many arenas in which you represented your district and community so admirably!

After reading all these truly noteworthy accomplishments by the MPS students and staff during this school year cut short by the COVID-19 pandemic, we hope you are as proud of your community's students and educators as Midland Public Schools is. Given this long, diverse list of accomplishments (which does not begin to capture everything), it can be no surprise that Midland Public School's is among the top 4% of the districts in the State of Michigan.

Thank you Midland Community for all of your support through the years. We know it truly does take a village to raise a child! Midland Public Schools is so fortunate to be located in this "Village."

Michael E. Sharrow is the Superintendent of Midland Public Schools. He authored this piece as part of the Daily News' Community Connections initiative.

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Community Connections: Midland Public Schools reflects on a memorable school year - Midland Daily News

Meet the coronavirus drones and robots Coronavirus / 07 Apr – RTE.ie

Opinion: fromhospitals to shops and policing, the use of drones and robots to carry out critical services can save lives during an epidemic

By Boris Galkin, TCD

As the world is rocked by the coronavirus crisis, governments everywhere have come together with the same safety instructions: stay home and avoid close contact with other people. For many, this lifestyle change simply entails taking their workload home and balancing it with their domestic chores: bookkeeping while babysitting, coding while cooking.

But leaving the house is still a necessity for purchasing food and essentials, which carries a risk of infection. Even worse off are those people whose jobs cannot be taken home and who must be in contact with potentially sick individuals.

The good news is that possible solutions for many of these issues are just around the corner, as the crisis has given a boost to a number of emerging technologies. The last 10 years have seen a technological revolution occur in the robotics and autonomous vehicle sectors. Largely invisible to the layperson, this crisis has pushed the technology out of its niche into the public sphere like never before.

From CGTN, a Chinese hospital is using robots to deliver medicine

So how are robots and drones playing a key role in containing the spread of the Covid-19 virus - and what changes we can expect to see in Ireland in the near future?Among those most at risk of contracting the virus are healthcare personnel such as doctors and nurses, who spend prolonged periods of time in areas with potentially infectious patients. Recognising this, several hospitals in China have begun adopting autonomous robots for many of their day-to-day tasks, such as delivering foodand medicineto patients, as well as disinfecting the hospital environment.

In Singapore, doctors are using telemedicine robots to remotely interact with patients from a safe distance whenever possible. These robots take the form of electric carts carrying cameras, video monitors and health measurement equipment. The medical personnel using these devices have the opportunity to increase the frequency of their patient interactions without having to resort to wearing PPE such as gloves and masks, which are in short supply.

Another key service which is seeing a robotic transformation is the delivery sector. With individuals staying home, the demand for online shopping and home delivery has skyrocketed. This puts delivery staff in a difficult situation, as any contact with the end-client puts both parties at risk.

From New China TV, autonomous delivery robots delivering goods in Wuhan

While leaving packages on doorsteps is an option, Chinese company JD.com has a better idea. Already a big player in autonomous delivery systems, this company has used the quarantine conditions to push their autonomous ground vehicles from the lab to the street. Taking the form of miniature electric vans, JD.com's delivery robots are safely driving along Wuhans roads and carrying out the last-mile stage of package delivery (that is, the stage where a package is sent from the local storage hub to the clients address). Capable of piloting themselves around complicated road conditions day or night, these robots are reported to be making the majority of the companys medical deliveries at the time of writing.

Law enforcement has not been left behind by this technological trend. With the lockdown come new laws which need to be enforced, and police organisations around the world are turning to remotely-piloted tools. These devices most often take the form of commercially available drones carrying loudspeakers or other communication equipment. Using them, police officers are able to remotely patrol city streets and public areas, identify the locations of non-compliant individuals and directly engage them. Not only do these devices allow the police to maintain their physical distance when carrying out their patrols, but their speed allows the police to oversee much larger areas than what they could achieve from the ground.

From ABC News, Madrid police are using drones tobroadcast messages during the coronavirus outbreak

While China has emerged as the leader in adopting these robotic tools, other countries are following closely. Ireland is currently lagging behind with this technology, due to a combination of economic and legislative issues. Current legislation prevents many of the applications of autonomous vehicles described above, particularly those used outdoors in public areas.

By law, autonomous or remotely piloted delivery vans are not permitted on Irish roads, and drones are heavily restricted in how they can use Irish airspace, even in the hands of the emergency services. Fortunately, the legislation on autonomous vehicles and drones is gradually changing to allow for more expanded use cases, such as food delivery in selected parts of the country.

The automation revolution was visible on the horizon for a while, but thiscrisis has suddenly brought it into full view

It is unlikely that we will see the technologies described above become adopted in Ireland during this current crisis, but the existing global trends unanimously point towards a near future where this technology is a daily part of our lives. Economists, scientists and tech experts worldwide are predicting that the virus will create an even greater demand for automating parts of the economy from the factory to the office.

When the virus outbreak comes to an end, the world will return to a new normal, with robots and autonomous devices appearing in various workplaces in increasing numbers. Working from home will become available to more people, while others will find aspects of their jobs taken over by machines, whether remotely piloted by the workers themselves or controlled by artificial intelligence. New business opportunities will emerge to cater to these automation demands, with new jobs created in the process. The automation revolution was visible on the horizon for a while, but thiscrisis has suddenly brought it into full view, and showed just how important the technology is for saving lives.

Boris Galkinis a PhD researcher atCONNECTinTrinity College Dublin

The views expressed here are those of the author and do not represent or reflect the views of RT

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Meet the coronavirus drones and robots Coronavirus / 07 Apr - RTE.ie