Machine learning is making NOAA’s efforts to save ice seals and belugas faster – FedScoop

Written by Dave Nyczepir Feb 19, 2020 | FEDSCOOP

National Oceanic and Atmospheric Administration scientists are preparing to use machine learning (ML) to more easily monitor threatened ice seal populations in Alaska between April and May.

Ice flows are critical to seal life cycles but are melting due to climate change which has hit the Arctic and sub-Arctic regions hardest. So scientists are trying to track species population distributions.

But surveying millions of aerial photographs of sea ice a year for ice seals takes months. And the data is outdated by the time statisticians analyze it and share it with the NOAA assistant regional administrator for protected resources in Juneau, according to aMicrosoft blog post.

NOAAs Juneau office oversees conservation and recovery programs for marine mammals statewide and can instruct other agencies to limit permits for activities that might hurt species feeding or breeding. The faster NOAA processes scientific data, the faster it can implement environmental sustainability policies.

The amazing thing is how consistent these problems are from scientist to scientist, Dan Morris, principal scientist and program director of MicrosoftAI for Earth, told FedScoop.

To speed up monitoring from months to mere hours, NOAAs Marine Mammal Laboratory partnered with AI for Earth in the summer of 2018 to develop ML models recognizing seals in real-time aerial photos.

The models were trained during a one-week hackathon using 20 terabytes of historical survey data in the cloud.

In 2007, the first NOAA survey done by helicopter captured about 90,000 images that took months to analyze and find 200 seals. The challenge isthe seals are solitary, and aircraft cant fly so low as to spook them. But still, scientists need images to capture the difference between threatened bearded and ringed seals and unthreatened spotted and ribbon seals.

Alaskas rainy, cloudy climate has led scientists to adopt thermal and color cameras, but dirty ice and reflections continue to interfere. A 2016 survey of 1 million sets of images took three scientists six months to identify about 316,000 seal hotspots.

Microsofts ML, on the other hand, can distinguish seals from rocks and, coupled with improved cameras on a NOAA turboprop airplane, will be used in flyovers of the Beaufort Sea this spring.

NOAA released a finalized Artificial Intelligence Strategy on Tuesday aimed at reducing the cost of data processing and incorporating AI into scientific technologies and services addressing mission priorities.

Theyre a very mature organization in terms of thinking about incorporating AI into remote processing of their data, Morris said.

The camera systems on NOAA planes are also quite sophisticated because the agencys forward-thinking ecologists are assembling the best hardware, software and expertise for their biodiversity surveys, he added.

While the technical integration of AI for Earths models with the software systems on NOAAs planes has taken a year to perfect, another agency project was able to apply a similar algorithm more quickly.

The Cook Inlets endangered beluga whale population numbered 279 last year down from about 1,000three decades ago.

Belugas increasingly rely on echolocation to communicate with sediment from melting glaciers dirtying the water they live in. But the noise from an increasing number of cargo ships and military and commercial flights can disorient the whales. Calves can get lost if they cant hear their mothers clicks and whistles, and adults cant catch prey or identify predators.

NOAA is using ML tools to distinguish a whales whistle from man-made noises and identify areas where theres dangerous overlap, such as where belugas feed and breed. The agency can then limit construction or transportation during those periods, according to the blog post.

Previously, the projects 15 mics recorded sounds for six months along the seafloor, scientists collected the data, and then they spent the remainder of the year classifying noises to determine how the belugas spent their time.

AI for Earths algorithms matched scientists previously classified logs 99 percent of the time last fall and have been since introduced into the field.

The ML was implemented faster than the seal projects because the software runs offline at a lab in Seattle, so integration was easier, Morris said.

NOAA intends to employ ML in additional biodiversity surveys. And AI for Earth plans to announce more environmental sustainability projects in the acoustic space in the coming weeks, Morris added, thoughhe declined to name partners.

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Machine learning is making NOAA's efforts to save ice seals and belugas faster - FedScoop

Pluto7, a Google Cloud Premier Partner, Achieved the Machine Learning Specialization and is Recognized by Google Cloud as a Machine Learning…

Pluto7 is a services and solutions company focused on accelerating business transformation. As a Google Cloud Premier Partner, we service the retail, manufacturing, healthcare, and hi-tech industries.

Pluto7 just achieved the Google Cloud Machine Learning Specialization for combining business consultancy and unique machine learning solutions built on Google Cloud.

With Pluto7 comes unique capabilities for machine learning, artificial intelligence, and analytics. Brought to you by a company that contains some of the finest minds in data science, able to draw on its surroundings in the very heart of Silicon Valley, California.

Businesses are looking for practical solutions to real-world challenges. And by that, we do not just mean providing the tech and leaving you to stitch it all together. Instead, Pluto7s approach is to apply innovation to your desired outcome, alongside the experience needed to make it all happen. This is where their range of consultancy services comes into play. These are designed to create an interconnected tech stack and to champion data empowerment through ML/AI.

Pluto7s services and solutions allow businesses to speed up and scale-out sophisticated machine learning models. They have successfully guided many businesses through the digital transformation process by leveraging the power of artificial intelligence, analytics, and IoT solutions.

What does this mean for a partner to be specialized?

When you see a Google Cloud partner with a Specialization, it indicates proficiency and experience with Google Cloud. Pluto7 is recognized by Google Cloud as a machine learning specialist with deep technical capabilities. The organizations that receive this distinction, demonstrates their ability to lead a customer through the entire AI journey. Pluto7 designs, builds, migrates, tests, and operates industry-specific solutions for their customers.

Pluto7 has a plethora of previous experience in deploying accelerated solutions and custom applications in machine learning and AI. The many proven success stories from industry leaders like ABinBev, DxTerity, L-Nutra, CDD, USC, UNM are publically available on their website. These customers have leveraged Pluto7 and Google Cloud technology to see tangible and transformative results.

On top of all this, Pluto7 has a business plan that aligns with the Specialization. Because of their design, build, and implementation methodologies they are able to successfully drive innovation, accelerate business transformation, and boost human creativity.

ML Services and Solutions

Pluto7 has created Industry-specific use cases for marketing, sales, and supply chains and integrated these to deliver a game-changing customer experience. These capabilities are brought to life through their partnership with Google Cloud, one of the most innovative platforms for AI and ML out there. The following solution suites are created to solve some of the most difficult problems through a combination of innovative technology and deep industry expertise.

Demand ML - Increase efficiency and lower costs

Pluto7 helps supply chain leaders manage unpredictable fluctuations. These solutions allow businesses to achieve demand forecast accuracy of more than 90%, manage complex and unpredictable fluctuations while delivering the right product at the right time -- all using AI to predict and recommend based on real-time data at scale.

Preventive Maintenance - Improve quality, production and reduce associated costs

Pluto7 improves the production efficiency of production plants from 45-80% to reduce downtime and maintain quality. They leverage machine learning and predictive analytics to determine the remaining value of assets and accurately determine when a manufacturing plant, machine, component or part is likely to fail, and thus needs to be replaced.

Marketing ML - Increase marketing ROI

Pluto7s marketing solutions improve click-through rates and predict traffic rates accurately. Pluto7 can help you analyze marketing data in real-time to transform prospect and customer engagement with hyper-personalization. Businesses are able to leverage machine learning for better customer segmentation, campaign targeting, and content optimization.

Contact Pluto7

If you would like to begin your AI journey, Pluto7 recommends starting with a discovery workshop. This workshop is co-driven by Pluto7 and Google Cloud to understand business pain points and set up a strategy to begin solving. Visit the website at http://www.pluto7.com and contact us to get started today!

View source version on businesswire.com: https://www.businesswire.com/news/home/20200219005054/en/

Contacts

Sierra ShepardGlobal Marketing Teammarketing@pluto7.com

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Pluto7, a Google Cloud Premier Partner, Achieved the Machine Learning Specialization and is Recognized by Google Cloud as a Machine Learning...

Syniverse and RealNetworks Collaboration Brings Kontxt-Based Machine Learning Analytics to Block Spam and Phishing Text Messages – Business Wire

TAMPA, Fla. & SEATTLE--(BUSINESS WIRE)--Syniverse, the worlds most connected company, and RealNetworks, a leader in digital media software and services, today announced they have incorporated sophisticated machine learning (ML) features into their integrated offering that gives carriers visibility and control over mobile messaging traffic. By integrating RealNetworks Kontxt application-to-person (A2P) message categorization capabilities into Syniverse Messaging Clarity, mobile network operators (MNOs), internet service providers (ISPs), and messaging aggregators can identify and block spam, phishing, and malicious messages by prioritizing legitimate A2P traffic, better monetizing their service.

Syniverse Messaging Clarity, the first end-to-end messaging visibility solution, utilizes the best-in-class grey route firewall, and clearing and settlement tools to maximize messaging revenue streams, better control spam traffic, and closely partner with enterprises. The solution analyzes the delivery of messages before categorizing them into specific groupings, including messages being sent from one person to another person (P2P), A2P messages, or outright spam. Through its existing clearing and settlement capabilities, Messaging Clarity can transform upcoming technologies like Rich Communication Services (RCS) and chatbots into revenue-generating products and services without the clutter and cost of spam or fraud.

The foundational Kontxt technology adds natural language processing and deep learning techniques to Messaging Clarity to continually update and improve its understanding of messages and clarification. This new feature adds to Messaging Claritys ability to identify, categorize, and ascribe a monetary value to the immense volume and complexity of messages that are delivered through text messaging, chatbots, and other channels.

The Syniverse and RealNetworks Kontxt message classification provides companies the ability to ensure that urgent messages, like one-time passwords, are sent at a premium rate compared with lower-priority notifications, such as promotional offers. The Syniverse Messaging Clarity solution also helps eliminate instances of extreme message spam phishing (smishing). This type of attack recently occurred with a global shipping company when spam texts were sent to consumers with the request to click a link to receive an update on a package delivery for a phantom order.

CLICK TO TWEET: Block #spam and categorize & prioritize #textmessages with @Syniverse & @RealNetworks #Kontxt. #MNO #ISPs #Messaging #MachineLearning #AI http://bit.ly/2HalZkv

Supporting Quotes

Syniverse offers companies the capability to use machine learning technologies to gain insight into what traffic is flowing through their networks, while simultaneously ensuring consumer privacy and keeping the actual contents of the messages hidden. The Syniverse Messaging Clarity solution can generate statistics examining the type of traffic sent and whether it deviates from the senders traffic pattern. From there, the technology analyzes if the message is a valid one or spam and blocks the spam.

The self-learning Kontxt algorithms within the Syniverse Messaging Clarity solution allow its threat-assessment techniques to evolve with changes in message traffic. Our analytics also verify that sent messages conform to network standards pertaining to spam and fraud. By deploying Messaging Clarity, MNOs and ISPs can help ensure their compliance with local regulations across the world, including the U.S. Telephone Consumer Protection Act, while also avoiding potential costs associated with violations. And, ultimately, the consumer -- who is the recipient of more appropriate text messages and less spam -- wins as well, as our Kontxt technology within the Messaging Clarity solution works to enhance customer trust and improve the overall customer experience.

Digital Assets

Supporting Resources

About Syniverse

As the worlds most connected company, Syniverse helps mobile operators and businesses manage and secure their mobile and network communications, driving better engagements and business outcomes. For more than 30 years, Syniverse has been the trusted spine of mobile communications by delivering the industry-leading innovations in software and services that now connect more than 7 billion devices globally and process over $35 billion in mobile transactions each year. Syniverse is headquartered in Tampa, Florida, with global offices in Asia Pacific, Africa, Europe, Latin America and the Middle East.

About RealNetworks

Building on a legacy of digital media expertise and innovation, RealNetworks has created a new generation of products that employ best-in-class artificial intelligence and machine learning to enhance and secure our daily lives. Kontxt (www.kontxt.com) is the foremost platform for categorizing A2P messages to help mobile carriers build customer loyalty and drive new revenue through text message classification and antispam. SAFR (www.safr.com) is the worlds premier facial recognition platform for live video. Leading in real world performance and accuracy as tested by NIST, SAFR enables new applications for security, convenience, and analytics. For information about our other products, visit http://www.realnetworks.com.

RealNetworks, Kontxt, SAFR and the companys respective logos are trademarks, registered trademarks, or service marks of RealNetworks, Inc. Other products and company names mentioned are the trademarks of their respective owners.

Results shown from NIST do not constitute an endorsement of any particular system, product, service, or company by NIST: https://www.nist.gov/programs-projects/face-recognition-vendor-test-frvt-ongoing.

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Syniverse and RealNetworks Collaboration Brings Kontxt-Based Machine Learning Analytics to Block Spam and Phishing Text Messages - Business Wire

Grok combines Machine Learning and the Human Brain to build smarter AIOps – Diginomica

A few weeks ago I wrote a piece here about Moogsoft which has been making waves in the service assurance space by applying artificial intelligence and machine learning to the arcane task of keeping on keeping critical IT up and running and lessening the business impact of service interruptions. Its a hot area for startups and Ive since gotten article pitches from several other AIops firms at varying levels of development.

The most intriguing of these is a company called Grok which was formed by a partnership between Numenta, a pioneering AI research firm co-founded by Jeff Hawkins and Donna Dubinsky, who are famous for having started two classic mobile computing companies, Palm and Handspring, and Avik Partners. Avik is a company formed by brothers Casey and Josh Kindiger, two veteran entrepreneurs who have successfully started and grown multiple technology companies in service assurance and automation over the past two decadesmost recently Resolve Systems.

Josh Kindiger told me in a telephone interview how the partnership came about:

Numenta is primarily a research entity started by Jeff and Donna about 15 years ago to support Jeffs ideas about the intersection of neuroscience and data science. About five years ago, they developed an algorithm called HTM and a product called Grok for AWS which monitors servers on a network for anomalies. They werent interested in developing a company around it but we came along and saw a way to link our deep domain experience in the service management and automation areas with their technology. So, we licensed the name and the technology and built part of our Grok AIOps platform around it.

Jeff Hawkins has spent most of his post-Palm and Handspring years trying to figure out how the human brain works and then reverse engineering that knowledge into structures that machines can replicate. His model or theory, called hierarchical temporal memory (HTM), was originally described in his 2004 book On Intelligence written with Sandra Blakeslee. HTM is based on neuroscience and the physiology and interaction of pyramidal neurons in the neocortex of the mammalian (in particular, human) brain. For a little light reading, I recommend a peer-reviewed paper called A Framework for Intelligence and Cortical Function Based on Grid Cells in the Neocortex.

Grok AIOps also uses traditional machine learning, alongside HTM. Said Kindiger:

When I came in, the focus was purely on anomaly detection and I immediately engaged with a lot of my old customers--large fortune 500 companies, very large service providers and quickly found out that while anomaly detection was extremely important, that first signal wasn't going to be enough. So, we transformed Grok into a platform. And essentially what we do is we apply the correct algorithm, whether it's HTM or something else, to the proper stream events, logs and performance metrics. Grok can enable predictive, self-healing operations within minutes.

The Grok AIOps platform uses multiple layers of intelligence to identify issues and support their resolution:

Anomaly detection

The HTM algorithm has proven exceptionally good at detecting and predicting anomalies and reducing noise, often up to 90%, by providing the critical context needed to identify incidents before they happen. It can detect anomalies in signals beyond low and high thresholds, such as signal frequency changes that reflect changes in the behavior of the underlying systems. Said Kindiger:

We believe HTM is the leading anomaly detection engine in the market. In fact, it has consistently been the best performing anomaly detection algorithm in the industry resulting in less noise, less false positives and more accurate detection. It is not only best at detecting an anomaly with the smallest amount of noise but it also scales, which is the biggest challenge.

Anomaly clustering

To help reduce noise, Grok clusters anomalies that belong together through the same event or cause.

Event and log clustering

Grok ingests all the events and logs from the integrated monitors and then applies to it to event and log clustering algorithms, including pattern recognition and dynamic time warping which also reduce noise.

IT operations have become almost impossible for humans alone to manage. Many companies struggle to meet the high demand due to increased cloud complexity. Distributed apps make it difficult to track where problems occur during an IT incident. Every minute of downtime directly impacts the bottom line.

In this environment, the relatively new solution to reduce this burden of IT management, dubbed AIOps, looks like a much needed lifeline to stay afloat. AIOps translates to "Algorithmic IT Operations" and its premise is that algorithms, not humans or traditional statistics, will help to make smarter IT decisions and help ensure application efficiency. AIOps platforms reduce the need for human intervention by using ML to set alerts and automation to resolve issues. Over time, AIOps platforms can learn patterns of behavior within distributed cloud systems and predict disasters before they happen.

Grok detects latent issues with cloud apps and services and triggers automations to troubleshoot these problems before requiring further human intervention. Its technology is solid, its owners have lots of experience in the service assurance and automation spaces, and who can resist the story of the first commercial use of an algorithm modeled on the human brain.

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Grok combines Machine Learning and the Human Brain to build smarter AIOps - Diginomica

Global machine learning as a service market is expected to grow with a CAGR of 38.5% over the forecast period from 2018-2024 – Yahoo Finance

The report on the global machine learning as a service market provides qualitative and quantitative analysis for the period from 2016 to 2024. The report predicts the global machine learning as a service market to grow with a CAGR of 38.

New York, Feb. 20, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Machine Learning as a Service Market: Global Industry Analysis, Trends, Market Size, and Forecasts up to 2024" - https://www.reportlinker.com/p05751673/?utm_source=GNW 5% over the forecast period from 2018-2024. The study on machine learning as a service market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and RoW for the period of 2016 to 2024.

The report on machine learning as a service market is a comprehensive study and presentation of drivers, restraints, opportunities, demand factors, market size, forecasts, and trends in the global machine learning as a service market over the period of 2016 to 2024. Moreover, the report is a collective presentation of primary and secondary research findings.

Porters five forces model in the report provides insights into the competitive rivalry, supplier and buyer positions in the market and opportunities for the new entrants in the global machine learning as a service market over the period of 2016 to 2024. Further, IGR- Growth Matrix gave in the report brings an insight into the investment areas that existing or new market players can consider.

Report Findings1) Drivers Increasing use in cloud technologies Provides statistical analysis along with reduce time and cost Growing adoption of cloud based systems2) Restraints Less skilled personnel3) Opportunities Technological advancement

Research Methodology

A) Primary ResearchOur primary research involves extensive interviews and analysis of the opinions provided by the primary respondents. The primary research starts with identifying and approaching the primary respondents, the primary respondents are approached include1. Key Opinion Leaders associated with Infinium Global Research2. Internal and External subject matter experts3. Professionals and participants from the industry

Our primary research respondents typically include1. Executives working with leading companies in the market under review2. Product/brand/marketing managers3. CXO level executives4. Regional/zonal/ country managers5. Vice President level executives.

B) Secondary ResearchSecondary research involves extensive exploring through the secondary sources of information available in both the public domain and paid sources. At Infinium Global Research, each research study is based on over 500 hours of secondary research accompanied by primary research. The information obtained through the secondary sources is validated through the crosscheck on various data sources.

The secondary sources of the data typically include1. Company reports and publications2. Government/institutional publications3. Trade and associations journals4. Databases such as WTO, OECD, World Bank, and among others.5. Websites and publications by research agencies

Segment CoveredThe global machine learning as a service market is segmented on the basis of component, application, and end user.

The Global Machine Learning As a Service Market by Component Software Services

The Global Machine Learning As a Service Market by Application Marketing & Advertising Fraud Detection & Risk Management Predictive Analytics Augmented & Virtual Reality Security & Surveillance Others

The Global Machine Learning As a Service Market by End User Retail Manufacturing BFSI Healthcare & Life Sciences Telecom Others

Company Profiles IBM PREDICTRON LABS H2O.ai. Google LLC Crunchbase Inc. Microsoft Yottamine Analytics, LLC Fair Isaac Corporation. BigML, Inc. Amazon Web Services, Inc.

What does this report deliver?1. Comprehensive analysis of the global as well as regional markets of the machine learning as a service market.2. Complete coverage of all the segments in the machine learning as a service market to analyze the trends, developments in the global market and forecast of market size up to 2024.3. Comprehensive analysis of the companies operating in the global machine learning as a service market. The company profile includes analysis of product portfolio, revenue, SWOT analysis and latest developments of the company.4. IGR- Growth Matrix presents an analysis of the product segments and geographies that market players should focus to invest, consolidate, expand and/or diversify.Read the full report: https://www.reportlinker.com/p05751673/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Global machine learning as a service market is expected to grow with a CAGR of 38.5% over the forecast period from 2018-2024 - Yahoo Finance

Buzzwords ahoy as Microsoft tears the wraps off machine-learning enhancements, new application for Dynamics 365 – The Register

Microsoft has announced a new application, Dynamics 365 Project Operations, as well as additional AI-driven features for its Dynamics 365 range.

If you are averse to buzzwords, look away now. Microsoft Business Applications President James Phillips announced the new features in a post which promises AI-driven insights, a holistic 360-degree view of a customer, personalized customer experiences across every touchpoint, and real-time actionable insights.

Dynamics 365 is Microsofts cloud-based suite of business applications covering sales, marketing, customer service, field service, human resources, finance, supply chain management and more. There are even mixed reality offerings for product visualisation and remote assistance.

Dynamics is a growing business for Microsoft, thanks in part to integration with Office 365, even though some of the applications are quirky and awkward to use in places. Licensing is complex too and can be expensive.

Keeping up with what is new is a challenge. If you have a few hours to spare, you could read the 546-page 2019 Release Wave 2 [PDF] document, for features which have mostly been delivered, or the 405-page 2020 Release Wave 1 [PDF], about what is coming from April to September this year.

Many of the new features are small tweaks, but the company is also putting its energy into connecting data, both from internal business sources and from third parties, to drive AI analytics.

The updated Dynamics 365 Customer Insights includes data sources such as demographics and interests, firmographics, market trends, and product and service usage data, says Phillips. AI is also used in new forecasting features in Dynamics 365 Sales and in Dynamics 365 Finance Insights, coming in preview in May.

Dynamics 365 Project Operations ... Click to enlarge

The company is also introducing a new application, Dynamics 365 Business Operations, with general availability promised for October 1 2020. This looks like a business-oriented take on project management, with the ability to generate quotes, track progress, allocate resources, and generate invoices.

Microsoft already offers project management through its Project products, though this is part of Office rather than Dynamics. What can you do with Project Operations that you could not do before with a combination of Project and Dynamics 365?

There is not a lot of detail in the overview, but rest assured that it has AI-powered business insights and seamless interoperability with Microsoft Teams, so it must be great, right? More will no doubt be revealed at the May Business Applications Summit in Dallas, Texas.

Sponsored: Detecting cyber attacks as a small to medium business

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Buzzwords ahoy as Microsoft tears the wraps off machine-learning enhancements, new application for Dynamics 365 - The Register

NantOmics and NantHealth Announce Results of Proprietary Machine Vision AI Software Study Demonstrating the Ability to Identify Aggressive Subtypes of…

Feb. 19, 2020 13:00 UTC

Study Published In Breast Cancer Research Shows How Deep-Learning Of Over 650 Breast Cancer Digital Pathology Images And Omics Data Can Be Used Together To Unlock Precise Mechanisms Of Therapy Resistance

CULVER CITY, Calif.--(BUSINESS WIRE)-- NantOmics, LLC, the leader in molecular analysis, and NantHealth, Inc. (NASDAQ: NH), a next-generation, evidence-based, personalized healthcare company, announced today the publication of a peer-reviewed study in Breast Cancer Research, a Springer Nature journal, on a novel AI technique in breast cancer. The study reports on a novel deep-learning system of digital pathology images and omics data used together to more precisely identify mechanisms of therapy resistance.

NantOmics scientists trained a deep-neural network on diagnostic slide images from 443 breast tumors that had previously undergone PAM50 subtyping to classify patches of the tumor images into four major molecular subtypes of breast cancer (basal-like, HER2-enriched, luminal A, and luminal B). The algorithm was then validated and demonstrated the capability to establish accurate breast cancer sub-typing in 222 samples from a retained set of tumors. By focusing the neural-networks attention on cancer-rich regions in the diagnostic images, this deep-learning algorithm identifies patient biopsies that are a mixture of different molecular subtypes, a classification that is less definable from molecular pathology techniques. Patients with heterogeneous biopsies such as mixtures of basal-like and luminal disease have a different survival profile than patients with homogeneous disease, and may potentially benefit from a more tailored therapy regimen.

Breast cancer can be subtyped into at least five distinct disease-types with very different prognoses and responses to therapy. These subtypes are characterized as clinically important, yet are typically only achievable by RNA expression profiling, Dr. Patrick Soon-Shiong, MD, Chairman and CEO of NantHealth explained. With this AI technique we achieved 87 percent accuracy rate in detecting which patients had basal-like breast cancer (i.e., triple negative breast cancer), one of the most aggressive subtypes, he said.

Our analysis builds on our breadth of advanced machine learning technologies to better support providers in therapeutic decision-making and to improve the capabilities of the underlying molecular analysis technology platforms that we use at NantHealth and NantOmics, said Soon-Shiong. Through the advances of machine vision and augmented intelligence, we have developed a rapid and cost-effective deep-learning technique to unlock the rich information in readily-available diagnostic slide images to define subtypes concordant with their underlying molecular designations.

Breast Cancer Research, a Springer Nature journal, is an international, peer-reviewed online journal publishing original research, reviews, editorials and reports in breast cancer. Breast Cancer Research is published by BMC, an open access publisher that produces over 250 scientific journals and according to its website, is the highest ranked breast cancer focused title in the field.

About NantOmics NantOmics, a member of the NantWorks ecosystem of companies, delivers molecular diagnostic and machine learning AI capabilities to provide actionable intelligence and molecularly driven decision support for patients and their providers. NantOmics is the first molecular in vitro diagnostics company to accurately identify mutations and true tumor mutation burden (TMB) from proprietary tumor-normal sequencing. The identified mutations and correlative calculation of true TMB, combined with proprietary expression analysis of immuno-oncology biomarkers and novel deep-learning derived digital pathology solutions, establish the framework for the appropriate use of targeted, chemo- and immunotherapies. NantOmics computational analysis engine, an organically grown, scalable, cloud-based infrastructure capable of processing and storing thousands of genomes per day, uses novel AI tools to combine expression analysis with near real-time genomic variance computing to generate precise N of 1 neoepitope vaccine therapies for cancer patients. For more information please visit http://www.nantomics.com and follow Dr. Soon-Shiong on Twitter @DrPatSoonShiong.

About NantHealth NantHealth, a member of the NantWorks ecosystem of companies, provides leading solutions across the continuum of care for physicians, payors, patients and biopharmaceutical organizations. NantHealth enables the use of cutting-edge data and technology toward the goals of empowering clinical decision support and improving patient outcomes. NantHealths comprehensive product portfolio combines the latest technology in payor/provider platforms that exchange information in near-real time (NaviNet and Eviti) and molecular profiling services that combine comprehensive DNA & RNA tumor-normal profiling with pharmacogenomics analysis (GPS Cancer). For more information, please visit http://www.nanthealth.com or follow us on Twitter, Facebook and LinkedIn.

Forward-Looking Statements: NantHealth This news release contains certain statements of a forward-looking nature relating to future events or future business performance. Forward-looking statements can be identified by the words expects, anticipates, believes, intends, estimates, plans, will, outlook and similar expressions. Forward-looking statements are based on managements current plans, estimates, assumptions and projections, and speak only as of the date they are made. Risks and uncertainties include, but are not limited to: our ability to successfully integrate a complex learning system to address a wide range of healthcare issues; our ability to successfully amass the requisite data to achieve maximum network effects; appropriately allocating financial and human resources across a broad array of product and service offerings; raising additional capital as necessary to fund our operations; achieving significant commercial market acceptance for our sequencing and molecular analysis solutions; establish relationships with, key thought leaders or payers key decision makers in order to establish GPS Cancer as a standard of care for patients with cancer; our ability to grow the market for our Systems Infrastructure, and applications; successfully enhancing our Systems Infrastructure and applications to achieve market acceptance and keep pace with technological developments; customer concentration; competition; security breaches; bandwidth limitations; our ability to continue our relationship with NantOmics; our ability to obtain regulatory approvals; dependence upon senior management; the need to comply with and meet applicable laws and regulations; unexpected adverse events; clinical adoption and market acceptance of GPS Cancer; and anticipated cost savings. We undertake no obligation to update any forward-looking statement in light of new information or future events, except as otherwise required by law. Forward-looking statements involve inherent risks and uncertainties, most of which are difficult to predict and are generally beyond our control. Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors, many of which are discussed in more detail in our reports filed with the Securities and Exchange Commission.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200219005341/en/

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NantOmics and NantHealth Announce Results of Proprietary Machine Vision AI Software Study Demonstrating the Ability to Identify Aggressive Subtypes of...

Personalized Medicine Market Worth $3.92 Trillion by 2026 – Insights Into Diagnostics, Medical Care, Nutrition & Wellness, and Therapeutics – P&T…

DUBLIN, Feb. 20, 2020 /PRNewswire/ -- The "Global Personalized Medicine Market Analysis 2019" report has been added to ResearchAndMarkets.com's offering.

The Global Personalized Medicine market is expected to reach $3.92 trillion by 2026, growing at a CAGR of 12.1% during the forecast period.

The efficient and advanced technology and higher prevalence of disease are driving the market growth. However, the higher cost of research and developments is hampering the market.

Based on the End-user, the hospital's segment is estimated to have a lucrative growth due to the lower cost personalized medicines availability in the hospitals. As the practice of personalized medicine becomes more widespread, hospitals will also experience the need to adapt. That does not mean every hospital and medical centre should try and drive the science, but they should be open to collaborations to facilitate such work.

The key vendors mentioned are Abbott Laboratories, Affymetrix Incorporated, Agendia N.V, Agilent Technologies, Inc, Amgen, Inc, Asuragen Incorporated, Bayer Healthcare Pharmaceuticals, Llc, Celera Diagnostics LLC, Celgene Corporation, Roche Diagnostics Corporation, Precision Biologics Incorporated, Siemens Healthcare Diagnostics, Inc, Sigma-Aldrich Corporation, Johnson & Johnson, Novartis AG, Decode Genetics Inc., Exact Science Corporation, Exagen Diagnostics Inc., GE Healthcare, and Genelex Corporation.

Key Questions Answered in the Report

Key Topics Covered

1 Market Synopsis

2 Research Outline

3 Market Dynamics3.1 Drivers3.2 Restraints

4 Market Environment

5 Global Personalized Medicine Market, By Product5.1 Introduction5.2 Diagnostics5.3 Personalized Medical Care5.4 Personalized Nutrition & Wellness5.5 Therapeutics

6 Global Personalized Medicine Market, By Technology6.1 Introduction6.2 Metabolomics6.3 Pharmacodynamics6.4 Pharmacogenetics6.5 Pharmacogenomics6.6 Pharmacokinetics6.7 Pharmacoproteomics6.8 Point-of-Care Testing6.9 Stem Cell Therapy

7 Global Personalized Medicine Market, By Therapeutic Area7.1 Introduction7.2 Autoimmune Diseases7.3 Blood Transfusion Safety7.4 Cancer Management7.5 Cardiovascular Diseases (CVD)7.6 Central Nervous System (CNS) Disorders7.7 Coagulation Therapy7.8 Diabetes7.9 Infectious Diseases7.10 Antiviral7.11 Neurology7.12 Psychiatry7.13 Oncology7.14 Immunology7.15 Respiratory

8 Global Personalized Medicine Market, By Distribution Channel8.1 Introduction8.2 Dietary Care Centers8.3 Hospital's Pharmacies8.4 Retail Pharmacies8.5 Other Distribution Channels

9 Global Personalized Medicine Market, By Application9.1 Introduction9.2 Biomarker Identification9.3 Clinical Research Applications9.4 Companion Diagnostics9.5 Health Informatics

10 Global Personalized Medicine Market, By End-user10.1 Introduction10.2 Academic Institutes10.3 Bio and Health Informatics Companies10.4 Clinical Care and Research Laboratories10.5 Contract Research Organizations10.6 Hospitals10.7 Molecular Diagnostic Laboratories and Testing Facilities10.8 Research Laboratories10.9 Service Providers10.10 Partner10.11 Venture Capitalists10.12 Other End-users

11 Global Personalized Medicine Market, By Geography11.1 North America11.2 Europe11.3 Asia-Pacific11.4 South America11.5 Middle East & Africa

12 Strategic Benchmarking

13 Vendors Landscape13.1 Abbott Laboratories13.2 Affymetrix Incorporated13.3 Agendia N.V13.4 Agilent Technologies Inc.13.5 Amgen Inc.13.6 Asuragen Incorporated13.7 Bayer Healthcare Pharmaceuticals, LLC13.8 Celera Diagnostics LLC13.9 Celgene Corporation13.10 Roche Diagnostics Corporation13.11 Precision Biologics Incorporated13.12 Siemens Healthcare Diagnostics Inc.13.13 Sigma-Aldrich Corporation13.14 Johnson & Johnson13.15 Novartis AG13.16 Decode Genetics Inc.13.17 Exact Science Corporation13.18 Exagen Diagnostics Inc.13.19 GE Healthcare13.20 Genelex Corporation

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The Gene Business – Business Today

Are you genetically predisposed to some diseases? Do you carry genetic mutations that can impact the health of your child? A debit card-sized IndiGenome card, recently unveiled by the government, will help you find the answers if your genetic information is captured in a database that India's umbrella research organisation - the Council of Scientific and Industrial Research (CSIR) - is building. Once your genome is sequenced from your blood sample and added to this database, the card can be used to read the information embedded in your genes, just as your debit card is used to generate a financial transaction statement from your bank's database.

Well, the card is not the key. Genome sequencing - or mapping the pattern of the basic building block of every living cell - is. A genome contains all of a living being's genetic material (simply put, the genome is divided into chromosomes, chromosomes contain genes, and genes are made of DNA). Each genome has approximately 3.2 billion DNA base pairs, and the way they are arranged, or variations and mutations in their pattern, can provide clues about the individual's health or ill health, inherited or acquired. Already, 1,008 individuals, chosen to represent India's social, ethnic and geographic diversity, have been issued such cards. Over 280 doctors in 70 institutions have been trained to make sense of such data. A CSIR institute, the Institute of Genomics and Integrative Biology (IGIB) - which is spearheading the Genomics for Public Health in India, also called IndiGen project - is planning to enrol 20,000 Indians for whole genome sequencing in the next couple of years to build a larger database. The data will be important for building the knowhow, baseline data and indigenous capacity in the emerging

area of precision medicine. IndiGen will have applications in a number of areas, including faster and more efficient diagnosis of rare diseases. The other benefits are cost-effective genetic tests, carrier screening applications for expectant couples, enabling efficient diagnosis of heritable cancers and pharmacogenetic tests to prevent adverse drug reactions.

In fact, IGIB leads two other programmes - Genomics for Understanding Rare Diseases India Alliance (GUaRDIAN) Network and Genomics and other Omics tools for Enabling Medical Decision (GOMED), led by Dr Mohammed Faruq, to see that the genome database and genetic screening leads to development of cost effective diagnostic tools and tests that are licensed out to private and public medical institutions.

The world over, fall in cost for genome sequencing (a reason for which is increase in computing power) is leading to path-breaking applications spanning the entire spectrum of healthcare - diagnosis to treatment and drug development to prevention and wellness - and unrelated fields such as agriculture, animal productivity, environment, sports and many more. Consider this: CSIR took six months to sequence the genomes of 1,008 Indians. Seventeen years ago, a global initiative led by the US National Academy of Sciences, had taken 12 years, and spent $3 billion, to complete the sequencing of the first human genome. Today, sequencing a person's genome does not cost more than $1,000. In fact, Sam Santosh, Chairman of MedGenome Labs, a private venture, says he can sequence a complete human genome in his Bengaluru lab for $500-600.

The Industry

The catalyst for the IndiGen project was advent of Next Generation Sequencing (NGS) in the last decade or so. (NGS helps an entire human genome to be sequenced in a day. The previous Sanger sequencing technology used to take over a decade.) The technology is being used by both IGIB and MedGenome for high-throughput sequencing, i.e. sequencing hundreds of thousands of genes in one go.

IndiGen is a good start but there are countries that are much ahead. Genomics England, a public-private partnership between the UK government and world's biggest NGS sequencing machine maker, Illumina, has completed sequencing of 1,00,000 genomes of British citizens comprising a mix of cancer patients, rare disorder patients and healthy people. A new agreement for sequencing of 3,00,000 genomes, with an option to increase it to 5,00,000 over the next five years, was signed by the two partners on January 13. "Countries such as Estonia and Iceland are attempting to sequence every single citizen and link the data with their health schemes. The US has decided to do it for every single rare disorder patient," says Praveen Gupta, Managing Director & Founder, Premas Life Sciences - the authorised partner of US-based Illumina in India.

"The global high-throughput genomics industry will be in the range of $10-12 billion. With an estimated 25-30 per cent annual growth, it is expected to become a $25-30 billion market in the next three-four years," he says. Premas sells tools (reagents, platforms, software, training) to labs that do genetic testing in India. With 90 per cent market share, it drives NGS technology in India, too. "The high-throughput genomics market in India, including reagents, instruments and services, will be about Rs 500 crore. Approximately 50,000 samples must be reaching India's clinical (service) market on an annual basis," says Gupta.

Dr Sridhar Sivasubbu and Dr Vinod Scaria, IGIB scientists at the forefront of the IndiGen programme, say genome sequencing is just one piece of the initiative. IGIB has two other programmes - Genomics for Understanding Rare Diseases India Alliance (GUaRDIAN) Network and Genomics and Other Omics Tools for Enabling Medical Decision (GOMED) - to ensure their genome database and genetic screening lead to development of cost-effective diagnostic tools and tests that can be licensed out to private and public healthcare institutions. "GUaRDIAN focuses on rare diseases. Given that we are a billion-plus people, even the rarest of the rare diseases is found in a few lakh people. So, this programme caters to 70 million people living with some genetic disease. We find technological solutions for these 7,000-odd diseases and partner with a network of 280 clinicians across 70-odd institutions to offer our solutions," says Sivasubbu.

"Patients and their families connect with us through the GUaRDIAN network. We sequence their genes to find the mutation, and once we find it, we go back to their communities with a cost-effective test to identify that mutation. You just have to look for that single mutation in others, and that's cost-effective," says Scaria. Instead of whole genome sequencing, which costs between Rs 50,000 and Rs 1,00,000, a single assay developed by IGIB through these programmes costs Rs 2,000. The team led by Sivasubbu and Scaria has developed 180 tests for 180 genes and transferred the technology to private diagnostic labs. The institute itself has catered to about 10,000 patients and carried about 25,000 tests in the last two years. "We have entered into partnerships with about a dozen companies. The format of the collaboration depends on the business models they follow," says Sivasubbu.

Premas Life Sciences

The authorised partner of US-based Illumina in India provides tools (reagents, platforms, software, training and troubleshooting) to labs engaged in genetic testing in India. With 90 per cent market share, it drives the New Generation Sequencing technology in India

It works in areas other than healthcare, too. For example, Tagtaste, an online platform for food professionals, uses the company's services to understand the genomics of taste. It has customers and partners such as Pepsico, Coca Cola, Nestle and ITC

Dr Lal PathLabs

The company has licensed diagnostic tests for 27 conditions from Institute of Genomics and Integrative Biology (IGIB)

Has a portfolio of more than 200 different types of tests

It is active in fields like rep- roductive health, cancer di- agnosis, pharmacogenomics

Medgenome Labs

The Bengaluru-based player considers itself as the private sector avatar of IGIB. It offers not just genetic tests but also carries out research. It has collaborated with Singapore's Nanyang Technological University to sequence 1,00,000 whole genomes from Asia. The Genome Asia project has already completed sequencing 10,000 whole genomes, of which about 8,000 are from India

MedGenomes research associates recently sequenced and analysed the genome of the Cobra snake. The findings, published in Nature, suggest the possibility of developing a new method of producing anti-venom completely in the lab.

Lifecell International

The company is in the genetic testing space. It has tied up with IGIB and offers tests ranging from basic screening (prenatal screening, newborn screening, etc) to high-end ones based on NGS. It tests more than 50,000 patient samples every month

Mahajan Imaging

The company has set up a new R&D wing to focus on cutting-edge scientific and clinical research and help radiology and genomics companies develop world-class clinically relevant products. The idea is to integrate imaging and genomic data

Trivitron Healthcare

The Chennai-based chain wants to develop tools using genomic data that can work on conventional platforms. It is talking to IGIB and trying to get its knowhow for manufacture of products for sale to pathology labs

The Private Hand

Dr Lal PathLabs, a pathology lab chain with big plans in the genetic testing space, has an entire department for such tests. "We offer tests of all levels - Karyotyping, which looks at the macro level, Microarrays, which offer intermediate resolution, and NGS, used to elucidate the DNA sequence at the micro level. The fields we are active in include prenatal reproductive health, cancer diagnosis and pharmacogenomics (study of how genes affect a person's response to drugs). We have more than 200 tests and conduct around 300 tests per day," says Dr Vandana Lal, Executive Director, Dr Lal PathLabs. The company has licensed tests for 27 conditions from IGIB. "The imported technology is expensive. The idea to partner with CSIR labs is to bring these cutting-edge technologies to Indian masses at a reasonable cost," says Dr Lal.

Lifecell International is another player in the genetic testing space that has tied up IGIB. "We offer tests ranging from basic screening (prenatal screening, newborn screening, etc.) to high-end ones based on NGS. We test more than 50,000 samples a month. PCR-based tests range from Rs 2,000-5,000 whereas tests based on NGS and those involving sequencing of large parts of the genome can cost upwards of Rs 20,000," says Ishaan Khanna, CEO, Biobank & Diagnostics, Lifecell. He believes the IndiGen database will help in development of better analysis and interpretation tools. "Our focus is on developing rapid genome testing for children in NICU (Neonatal ICU) and similar other scenarios where doctors need clear actionable results in the shortest possible time. IndiGen provides the right mix of Indian genome database," he says.

But not every partnership is for access to cost-effective tests. Mahajan Imaging, a medical imaging chain, has set up a Centre for Advanced Research in Imaging, Neuroscience and Genomics to focus on research and helping radiology and genomics companies develop clinically relevant products. The idea is to integrate imaging and genomic data. "We started the project six months ago and are among the first imaging companies to get into genomics. In the next three-five years, it will be possible for an AI algorithm to look at the radiology image and give genomic readings on it," says Vidur Mahajan, Associate Director, Mahajan Imaging.

Chennai-based Trivitron Healthcare sees in IndiGene data an opportunity to develop multiple testing platforms. It wants to develop tools using genomic data that can work on conventional platforms. "There are almost 1,00,000 pathology labs in India. Hardly 500-1,000 must be doing genetic testing. Companies like ours are talking to IGIB and trying to get the knowhow to manufacture products for a larger population," says Jameel Ahmad Khan, Head, R&D, Trivitron. "IGIB will develop the knowhow, provide proof of concept, and we will convert it into a product which pathology labs without highly trained manpower can also run," he says.

Bengaluru-based Medgenome Labs considers itself a private sector avatar of IGIB, perhaps even a couple of years ahead in research and development. The company not only does genetic tests but also carries out research. It has collaborated with Singapore's Nanyang Technological University to sequence 1,00,000 whole genomes from Asia. The Genome Asia project has already completed sequencing of 10,000 whole genomes, of which about 8,000 are from India. On December 4, international journal Nature published the initial findings from the project - genetic variation, population structure, disease associations, etc., from a whole-genome sequencing reference dataset of 1,739 individuals of 219 population groups and 64 countries across Asia. "We sequence a person's genes and other relevant parts of the genome for specific mutations to understand what is causing the disease and specific drugs and dosage the person will respond to. We also help pharmaceutical companies understand genomes and discover new drug targets and biomarkers," says Sam Santosh, Chairman, MedGenome. With about 120 sales people, the company claims it is generating samples from around 10,000 clinicians across the country. "We were the first to enter the market. In that sense, we created the market, and would be having 60-65 per cent market share. The sequencing market must be in the range of $70-75 million," says Santosh. The company expects its diagnostic business to touch $100 million in four years. Interestingly, MedGenome's research associates recently sequenced and analysed the genome of Cobra snake. The findings, published in Nature, suggest the possibility of developing a new method of producing anti-venom completely in the lab.

Other Sectors

Illumina's India partner Premas Life Sciences is not selling its next generation sequencers only to healthcare firms. Gupta says it has more than 200 installations in India alone. "Anything which is living has a DNA nucleic acid and can be sequenced. We have a mass research market and practically every institute has the sequencer. Somebody will be working on cow, somebody on rice, a third institute on some bacteria," says Gupta.

IGIB researchers Dr Sridhar Sivasubbu and Dr Vinod Scaria vouch for this. The institute is getting requests, including partnership offers, from non-medical players. Tagtaste, an online platform for food professionals, wants to understand the genomics of taste. "In a lighter vein, you could say that the efficiency of a professional wine taster depends on his genes," says Scaria. With customers and partners such as Pepsico, Coca Cola, Nestle and ITC, and a clientele that includes chefs of global hotel chains, taste is serious business. "The point is, if a person is paying Rs 3,000 for a curry or Rs 5,000 for a soup, you better get the taste right," says Scaria. IGIB also works with Adam's Genetics for R&D and product development in the area of fitness. "One of the companies works in the cricket industry. Each player can be genetically tested for performance and food intake because not all muscles have the same size and some people gain weight, some don't gain muscle mass, while some may be more prone to injury. Genetic tests can find out who is prone to injury, or whether weightlifting is the right exercise for a player or not," says Sivasubbu.

The Future

Indians are 17 per cent of the world's population. But only 0.2 per cent genomic data is from the Indian population. This is one area where India can lead. We have so many diseases, and if we can provide the genetic design, the world can develop diagnostics and therapies. "We can create ideas. We didn't invent computers but we created the IT industry. In the same way, we didn't invent genomic sequences but tomorrow we can create a genome informatics economy," says Premas' Gupta.

There are other possibilities, too. "A lot of pundits say that in the next five-six years, 15 per cent of the world's population will be whole genome sequenced. If I require 100 GB data for a genome sequence, for 1.5 billion people, 25-30 exabytes of data will be needed. The entire data content on YouTube, globally, is 0.8 exabytes. Imagine the kind of data generation and analytics possibilities we are talking about," says Gupta. "We need people to analyse this data. If we can take the lead and train our manpower, we can move the world, we can create a new industry which can lead for the next 20 years just the way the IT industry did," he adds. Incidentally, Gupta claims that TCS has already bought Illumina's sequencing platform. So has WIPRO. It seems IT companies are already sensing an opportunity.

Sivasubbu says it took India 10 years to scale up from sequencing one genome to 1,000 genomes. "In the next decade, it may be a million."

@joecmathew

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The Gene Business - Business Today

New Discoveries in Human Anatomy – The Scientist

In the 16th century, when the study of human anatomy was still in its infancy, curious onlookers would gather in anatomical theaters to catch of a glimpse of public dissections of the dead. In the years since, scientists have carefully mapped the viscera, bones, muscles, nerves, and many other components of our bodies, such that a human corpse no longer holds that same sense of mystery that used to draw crowds.

New discoveries in gross anatomythe study of bodily structures at the macroscopic levelare now rare, and their significance is often overblown, says Paul Neumann, a professor who specializes in the history of medicine and anatomical nomenclature at Dalhousie University. The important discoveries about anatomy, I think, are now coming from studies of tissues and cells.

Over the last decade, there have been a handful of discoveries that have helped overturn previous assumptions and revealed new insights into our anatomy. Whats really interesting and exciting about almost all of the new studies is the illustration of the power of new [microscopy and imaging] technologies to give deeper insight, saysTom Gillingwater, a professor of anatomy at the University of Edinburgh in the UK. I would guess that many of these discoveries are the start, rather than the end, of a developing view of the human body.

Here is a sampling of some of those discoveries.

The lymphatic system, a body-wide network of vessels that drains fluids and removes waste from tissues and organs, was long-believed to be absent from the brain. Early reports of lymphatic vessels in the meninges, the membrane coating the brain, date as far back as the 18th centurybut these findings were met with skepticism. Only recently has this view been overturned, after a 2015 report of lymphatic vessels in mouse meninges and the 2012 discovery of the so-called glymphatic system, an interconnected network of glial cells that facilitates the circulation of fluid throughout mouse brains. In 2017, neuroimaging work revealed evidence for such lymphatic vessels in human meninges.

In 2018, researchers reported that the space between cells was a collagen-lined, fluid-filled network, which they dubbed the interstitium. They proposed that this finding, which emerged from close examinations of tissue from patients bile ducts, bladders, digestive tracts, and skin, may help scientists better understand how tumors spread through the body. The team also called the interstitium a newly-discovered organ, but many dismissed this claim. Most biologists would be reticent to put the moniker of an organ on microscopic uneven spaces between tissues that contain fluid, Anirban Maitra, a pathologist at the University of Texas MD Anderson Center, told The Scientistlast year.

Until recently, the prevailing view among scientists was that the mesentery, the large, fan-like sheet of tissue that holds our intestines in place, consisted of multiple fragments. In 2016, after examining the mesentery of both cadavers and patients undergoing surgery, a team of researchers concluded that the mesentery was actually a single unit. This wasnt the first time the mesentery was described as continuousin one of the first depictions of the structure, Leonardo da Vinci also portrayed it in this way. But in the 2016 paper, the scientists argued that its continuity should qualify the mesentery as an organ. As with the interstitium, however, other experts have objected to this claim. In both of these cases, there seems to have been a misunderstanding of what the term organ means, Neumann says.

laurie okeefe

In January 2019, scientists described a previously unknown web of capillaries that pass through the bones of mice. Textbooks describe large veins and arteries jutting out the ends of bones, but this newly-described network of tunnels provide a faster route for blood cells produced in the bone marrow to enter the circulation. The research team also looked at human bones using a variety of methods: taking photos from patients undergoing surgery, conducting MRI scans of a healthy leg, and investigating extracted samples under a microscopeand revealed a similar, albeit less extensive, system of capillaries.

Last October, researchers reported that muscles typically seen in reptiles and other animalsbut not peoplewere present in the limbs of human embryos. Using a combination of immunostaining, tissue clearing, and microscopy, the team generated high-resolution 3-D images of upper and lower limb muscles in tissue samples from preserved 8- to 14-week-old embryos and fetuses. These structures, which disappear before birth, may be anatomical remnants of our evolutionary ancestors that disappear during the early stages of development, the authors suggest. They only examined 13 images, however, so experts caution that its a preliminary finding that needs to be replicated in a larger sample.

The fabella, a tiny bone located in a tendon behind the knee, is becoming more common in humans, according to a study published last spring. After reviewing 58 studies on fabella prevalence in 27 different countries, researchers reported that people were approximately 3.5 times more likely to have the little bone in 2018 than 1918. The cause of this trend remains an open question, but the authors suggest that changes in muscle mass and bone lengthdriven by increased diet quality in many parts of the worldcould be one explanation.

Diana Kwon is a Berlin-based freelance journalist. Follow her on Twitter@DianaMKwon.

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New Discoveries in Human Anatomy - The Scientist

Go Inside the Off-Broadway Opening of Anatomy of a Suicide – Playbill.com

Atlantic Theater Company celebrated the official opening of Alice Birch's Anatomy of a Suicide February 18. The play, which won the 2018 Susan Smith Blackburn Prize, premieres in the U.S. following an acclaimed London run.

An exploration of mothers and daughters, Anatomy of a Suicide details the story of three generations of women whose lives play out simultaneously onstage.

Directed by Obie winner Lileana Blain-Cruz, the cast is made up of Celeste Arias (Uncle Vanya), Jason Babinsky (Network), Gabby Beans (Marys Seacole), Ava Briglia (John Mulaney and the Sack Lunch Bunch), Carla Gugino (Jett), Julian Elijah Martinez (Network), Jo Mei (The Great Wave), Vince Nappo (Reign), Miriam Silverman (Junk), and Richard Topol (Indecent).

The run, which began February 1 and is scheduled through March 15, features scenic design by Mariana Sanchez, costume design by Kaye Voyce, lighting design by Jiyoun Chang, projection design by Hannah Wasileski, and casting by Telsey + Company: Karyn Casl and Madison Sylvester.

Birch has been a two-time finalist for the Susan Smith Blackburn Prize with her plays Many Moons and Revolt. She said. Revolt again. She is the winner of the Arts Foundation Award for Playwriting 2014 and the co-winner of the George Devine Award for Most Promising Playwright 2014.

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Go Inside the Off-Broadway Opening of Anatomy of a Suicide - Playbill.com

‘Grey’s Anatomy’ fans to find out what happened to Dr. Alex Karev – CNN

The writers were left to create a storyline for original cast member Justin Chambers following his sudden departure from the medical drama. His last episode aired in November.

Vernoff explains that Chambers' character arc "was a very careful threading of a needle, where we are giving a little bit of information and pain to Jo," she said of Camilla Luddington's character, Jo Karev, adding, "We're, episode by episode, illuminating the story of where Alex is. And it takes us quite a few more episodes to get there and to give the audience clarity."

Luddington's Jo was also taken into consideration when figuring out what to do with Chambers' character.

"Jo went through so much pain and so much grief just last season that I wanted to be careful," Vernoff said. "And so it's a bit of a mystery (what's going on with Alex), so that we don't watch Jo in the same place that we watched her in last season. We did it as carefully as we could. But it takes a while to get there," she said.

"For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time."

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'Grey's Anatomy' fans to find out what happened to Dr. Alex Karev - CNN

The 2015 Chapel Hill Shooting: Was It a Hate Crime? – The Marshall Project

This documentary was published in partnership with TIME.

Five years ago, three Muslim college students were gunned down in their home, in Chapel Hill, North Carolina, by a white neighbor, Craig Hicks. Deah Barakat and Yusor Abu-Salha, two of the victims, had just been married. They were enjoying dinner with the brides sister, Razan Abu-Salha, who was also killed. Police labeled the crime a parking dispute, sparking outrage among Muslims around the globe.

The killings came amid a surge in reports of bias-motivated attacks against Muslims in America, which spiked 67 percent in 2015, according to FBI data. Overall that year, 5,850 hate crimes were reported across the countrya number that continues to grow. Last year, the FBI announced more than 7,120 reported hate crimes, with physical assaults reaching a 16-year high. Although the latest data shows fewer attacks against Muslims and Arab-Americans, civil rights groups say there are likely many more anti-Muslim incidents, including bullying and discrimination, that do not appear in FBI data.

Did the murder of the college students in Chapel Hill meet the definition of a hate crime? That question is at the heart of our new documentary re-examining a case that reverberated around the world. This film sheds light on the way the nation is responding to rising levels of bias-fueled violence and how we define what constitutes a hate crime under the law.

Produced by

Director/Producer Emily Kassie

Editor Margaret Cheatham Williams

Additional editor Arpita Aneja

Cinematography Nausheen Dadabhoy, Emily Kassie and Jason Arthurs

Supervising producers Justine Simons and Geraldine Sealey

Co-producer Joseph Neff

Additional footage Judy Phu, Caleb Goodnight, Emily Rhyne, Ray Whitehouse and Tarek Albaba

Motion graphics the STUDIO, Mary Nittolo and Eric Schutzbank

Sound Dan Dzula

Color Marika Litz

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The 2015 Chapel Hill Shooting: Was It a Hate Crime? - The Marshall Project

The anatomy of a perfect 10: Analyzing Alabama gymnastics routines – The University of Alabama Crimson White

Katie Windham | @ktwindham5, Staff ReporterFebruary 20, 2020

From mount to dismount, a collegiate uneven bars routine lasts about 15-20 seconds. Behind that 15-second routine are years of training, months of preparation and just the right combination of skills and point values.

Many gymnasts on the Alabama roster competed at the Elite Gymnastics or Junior Olympics levels, where scoring is completely different than in college. Sophomore Emily Gaskins, who was a three-time member of the United States national team, made adjustments to her routine while at Alabama.

Our scoring systems were, if you got a 14 and 15, it was awesome, Gaskins said. And coming to college, you dont have that score and it only goes to 10. You take out a lot of skills in your routine. Youre going from about a minute bar routine to a 10-second, 15-second bar routine.

At the level of a program like Alabama gymnastics, outside of vault which is a one-skill routine every gymnasts routine starts at a 10.0 value. It takes a lot to reach that value, including the basics that must be included in every routine.

Your skills are basically labeled a value of an A, B, C, D and E, coach Dana Duckworth said. When you develop a routine, there are minimum requirements in bars, beam and floor. You have to have three As, two Bs and two Cs.

Every Alabama gymnast has more than As, Bs and Cs in their routine. For example, senior Wynter Childers starts her bars routine out with a kip cast handstand, which is an A skill. She will then release to the high bar with a Maloney, a D-level skill. Then she goes immediately back to the low bar with a bail, which is another D skill.

Childers gets a one-tenth bonus for each D-level skill. Because she connects the two, she gets another 0.20 bonus, which is the CV, or connection value. And those are just three of the skills in her routine.

Every routine requires a total of eight skills, even if the 10.0 start value has already been reached. For example, freshman Ella Burgess routine had all the required difficulty to reach a 10.0 start value on beam, but she only had seven skills, so they had to add a switch leap.

Even though 15-20 seconds seems like a short amount of time to a fan watching from the stands or on TV, there is a lot running through a gymnasts mind during that time. For some, like senior Shea Mahoney, it helps to constantly stay thinking throughout the routine.

So Ill mount the bar, and I just have mental cues, Mahoney said. For me its more of a feeling, and then little tiny words. If I just keep kind of talking to myself throughout the whole bar routine, that is how Ill get through.

Mahoneys mental cues for bars are: mount, tight cast, tight hips, catch the bar, jump to the high bar, tight hips, catch the bar, giant, giant, squeeze your core, look at the ground, wait another second and then really look at the ground, dismount.

Before mounting the bars, Mahoney said she smiles because it releases any last bit of tension or nervousness.

For sophomore Jensie Givens, every uneven bars routine starts with a nod to assistant coach Ryan Roberts, a nod to Gaskins and a deep breath to remind herself that Gods got her. And then she moves into her routine of handstands, a Jaeger (a D-level skill), a bail to the low bar, three giants and a double layout dismount, hoping for the all-important stick on the landing.

Alabama will once again put these skilled routines to the test when it takes on the Florida Gators in Gainesville, Florida, on Friday at 5 p.m.

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The anatomy of a perfect 10: Analyzing Alabama gymnastics routines - The University of Alabama Crimson White

Should Meredith & Carina Be Worried About DeLuca on ‘Grey’s Anatomy’? (VIDEO) – TVInsider

DeLuca (Giacomo Gianniotti) is determined to figure out what's wrong with his patient, Suzanne (Sarah Rafferty), but his sister Carina (Stefania Spampinato) is worried about him.

As seen in TV Insider's exclusive sneak peek of Thursday'sGrey's Anatomy, she's thinking about the family's history, specifically her father's. (You'll recall that she was the one who noticed signs that their father is bipolar.)

"I came to Seattle because Andrew is now the same age as our father was when his symptoms started," Carina explains to Meredith (Ellen Pompeo). And it's not just his behavior when it comes to trying to treat Suzanne."Failing to understand or properly consider the consequences of your actions is a sign of mania," Carina continues.

Watch the clip above to see the examples she lists and Meredith's reaction.

(ABC/Gilles Mingasson)

In "A Diagnosis," DeLuca is irritated when Meredith takes over with Suzanne. Plus, Jackson (Jesse Williams), Owen (Kevin McKidd), and Jo (Camilla Luddington) work on a couple injured in a bear attack, and Levi (Jake Borelli) is hurt when Nico (Alex Landi) doesn't want him to meet his parents.

Grey's Anatomy, Thursdays, 9/8c, ABC

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Should Meredith & Carina Be Worried About DeLuca on 'Grey's Anatomy'? (VIDEO) - TVInsider

The anatomy of a perfect country what makes a nation great? – Telegraph.co.uk

How big would it be? What hours would we work? What would the weather be like? We muse on the make-up of an ideal nation

Nearly 200,000 years ago, humans made their first strides out of Africa in a quest that would see them one day populate the whole world. Century by century, civilisations rose and fell from east to west; their varying cultures preserved and segregated by oceans.

Societies in what are now the Americas had no idea of the inventions being made in China. Indigious tribes in Australia knew nothing of the clans in Africa. Only in recent history have we joined the dots and only today do we have the whole picture.

And so, armed with these insights, imagine you are a wizard with the power to create a new nation on Earth in which to live, with different attributes cherry-picked from any countries you like. What would it look like? It would probably not, as far as Im concerned, be a land-locked municipality with the climate of Siberia, the food of Lithuania, the attitude of Parisians and the railway network of Britain.

I did some digging on the subject, reviewed the worlds 'happiest countries'and their customs, spoke to the rest of the Telegraph Travel team, and posed the question to readers - all to gather the material needed with which to invent a Franken-nation of excellence. Heres how it came out...

A good place to start, given our British tendency to pontificate on the weather; though like every other category to follow, a highly subjective matter.

Some appreciate proper seasons, others yearn for a permanent state of summer, and there are even those who choose to endure 100 days a year of total darkness. Personally, I favour desert conditions - hot and dry during the day, cool in the evenings - and steer clear of jungles; their claustrophobic humidity and multitude of insects. I'd settle on the climate of coastal California. Residents of this state have every reason to brag, and not just because it's so reliably sunny...

Warmth aside, California benefits from a host of topographic perks that make it unique. First, its terrain is exceptionally diverse (lofty peaks, rich forest, golden beaches). Crucially, its high mountain ranges shelter it from powerful polar gusts from the north, and the generally clockwise direction of the prevailing winds limit the force of Pacific storms.

Its equatorial position ensures plenty of sunshine, with warm wind that blows in from the eastern Mojave Desert. But the 'California Current' that brings cool ocean water down the east coast absorbs enough solar energy to keep the air from being too oppressively hot, and renders the humidity very low compared to other regions on the same latitude.

Unlike California, however, this Franken-nation would like to remain, like Britain, an island - not too far from the nearest mainland but far enough to enjoy our personal space. Ideal, too, in the event of an apocalypse.

Is bigger better? Undeniably, there are political advantages to having a far-reaching territory, not to mention the lifestyle privileges of being able to ski, sunbathe, swim and mountain-climb without stepping past your own borders.

But just like the running of a major corporation over a medium-sized company, there are drawbacks to being large. There's more to manage, it's harder to make significant constitutional changes should you need to, and the more land you cover, the more diverse its population and at-odds their prerogatives - precisely the reason Brexiteers think wed be better off out of the EU.

And while some of the biggest countries in the world, primarily the US and China, may indeed be the richest, it's actually the smaller nations that are the wealthiest per capita - a far better metric for the people living there. Qataroccupies just 11,586 sq km (that's 20 times smaller than Britain) and tops the list with a GDP per capita of nearly 100,000 (more than double that of the UK). Yes, they have oil, but other pint-sized nations with a high GDP per capita also include Luxembourg, Switzerland, Macau and Brunei.

On the other hand, with being a small country comes a limiting perspective. Natives from large nations like Australia and the USA often scoff when they hear a Briton describe their journey from, say, London to Edinburgh as being 'long'.

This is probably a category for the Goldilocks approach; not too big, not too little.South Africa seems like a good size, allowing for the diversity of landscape enjoyed by larger countries - from its great safari bushland in the east, its Kalahari desert conditions in the north west, and abundance of coastline either side - without being so sprawling as to be unmanageable. In short, just right.

Confucius had it right when he predicted 1,500 years ago on the prospect of swelling communities: "Excessive growth may reduce output per worker, repress levels of living for the masses and engender strife." Of all the problems our planet now faces, overpopulation is the elephant in the room. So how many people should our Franken-nation add to the mix?

Thinkers and planners have been tossing theories around as to what makes the ideal population density since long before Confucius. These days, at least according to renowned Stanford population analyst Paul Ehrlich, the optimum population worldwide - "enough to guarantee the minimal physical ingredients of a decent life to everyone" is 1.5 to 2 billion people. We're currently at 7.7 billion, hurtling fast towards 9 billion by 2050.

Too many humans living egg-and-bird is obviously not a good thing. But neither, some say, is having a very sparse population; the countries with the fewest residents today (Mongolia and Greenland) tend to be so because of their harsh environments and you could argue, are a bit lonely.

Personally though, as someone who prefers empty sand dunes to city breaks, I say the less people the better. Other countries with low population densities include the likes of Namibia, Australia and Iceland - all very appealing domains. In Icelands case, its about nine people for every square mile.

How people like to get from A to B varies hugely, no more so than on our travel desk. If Oliver Smith had his way, our Franken-nation would have the bicycle-friendly ethos of the Netherlands. Adrian Bridge is only ever truly happy on a train. Gavin Haines has entirely given up flying.

Ideal, then, would be a country built to accommodate all modes of transport. For an ultra-efficient rail network, we should look to Japan's bullet trains. For tip-top cycle lanes, Scandinavia wins hands down - in Copenhagen, for example, more than 60 per cent of its residents get to work or school by bike.

Back to Asia we go for the best underground metro system, where Hong Kong's MTR is immaculately clean, brilliantly quick and reliable, Wi-Fi fitted and widely praised by travellers the world over.

As for the roads, the World Economic Forum reckons the United Arab Emirates has the best system in terms of both its infrastructure and quality of the tarmac. I'd also adopt Germany's Autobahn system for motorways.

Oh and please, pavements withpedestrian slow lanes.

Spanish? Greek? Chinese? Japanese? Thai? Mexican? Indian? Or dare we say it, British? No, its Italian cuisine that gets my vote.

Indulgent dishes - pizza, pasta, tiramisu - and an abundance of fresh produce - olive oil, tomatoes, artichoke, basil - strike an elegant balance between health and gluttony. And I appear to be in good company. Last year, an international YouGov study polled people on the topic across 24 countries and Italian came out on top, followed by Chinese (Britains favourite) and Japanese.

Our own cuisine didn't fare so well. Despite 90 per cent of British responders signalling their approval, foreigners do not agree. The biggest haters were the Japanese, along with the Germans, Spaniards and French.

Looking back over the greatest innovations of all time, it is inventors from China and the UK who have proved most prolific. China gave us paper, the compass,
the first mechanical clock, gunpowder, rockets and alcohol. Britain can take a bow for introducing the steam engine, the telephone, the lightbulb and the World Wide Web; not to mention carbonated water, the lawnmower, the Mackintosh coat and Dolly the cloned sheep.

Currently, however, Switzerland has been ranked as the world leader in innovation for the seventh year running, by the Global Innovation Index report, followed by Sweden and the US. The UK takes fifth place. Why does Switzerland keep winning, aside from its exports of velcro, the Red Cross, and direct democracy? Lacking much in the way of natural resources, it's a country that has been forced to be creative in other ways.

Says Credit Suisse: "Since the country was largely spared the ravages of the Second World War, it was in an excellent position, with intact, export-oriented production facilities, to benefit from Europes post-war reconstruction. Also helpful is Switzerlands liberal, stability-oriented economic policy and traditional emphasis on hard work, dedication and education." The country holds more patents than any other country in relation to population.

What of the more tangible creature comforts? Switzerland's tap water please, it's the cleanest in the world and totally negates the need for plastic bottled mineral water. But Japans high-tech loos, I'm told, are far superior to our Western bogs (though Hazel Plush sings the praises of Dubai's lavish public bathrooms). Also Japan's multitude of vending machines - there's one on almost every block and they sell a vast array of essentials (groceries, umbrellas, tights, wine) - so convenient.

The country with the fastest internet? That depends on which report you look at, but Singapore and Taiwan generally dominate - both countries in which the average time it takes to download a HD film is about eight minutes, compared to half an hour in the UK.

I'd also yoink Finland's abundance of saunas (it is estimated that there are two million of them, for a population of 5.3 million).

It might surprise you to learn which country boasts the world's best healthcare system, according to the World Health Organisation: France, with a fairly complex orchestration of both private and public practises, largely funded (about 70 per cent of it) by the government, the rest generally covered by insurance.

Writing for The Local, London-based French blogger Muriel Demarcus says he experienced quite the culture shock when he first encountered the NHS. In the UK, he states, it's much harder to get an appointment, the GPs don't take patients seriously enough, surgery waiting lists are too long, and a trip to the dentist is at least double the price compared with France.

"The weird thing is that, come to think of it, the health budget is similar in France and in the UK (OK, a bit higher in France, but not massively higher)" he writes.

French hospitals it is, then. One thing I'd certainly want for our Franken-nation, however, would be a Swiss Dignitas-style clinic which permits terminal patients to end their lives should they wish to, with the dignity we afford our pets. Keeping people alive against their will when they're suffering seems ludicrous to me, not to mention expensive. Last year, the largest ever poll on human euthanasia, conducted by Populus, revealed that 84 per cent of Britons support it too.

Where to start? With the very sensible rules that surely every country should adopt, perhaps. In Argentina, you are automatically an organ donor unless you choose to opt out; a policy which saves thousands of lives a year.

The fact that more than a third of the world's food goes to waste every year is a travesty. Thus, in France, it is illegal for large supermarkets to throw away unsold food; they must instead donate it to those in need.

I'd also instigate a single-use plastic tax (something MPs are currently pushing for) to incentive the use of recyclable packaging.

Beyond that, in the interests of not igniting war in the comments box, we'll leave aside the more divise matters of drug legalisation, university quotas, religious rights, animal welfare laws and Heathrow's second runway - in favour of lighter topics...

Of everyone we heard from on this - the single foreign tradition to come out as most desirable? Siestas. All of us, it seems, are tired and would welcome a better work-life balance. Some countries are starting to address it. In the US, and particularly Silicon Valley, 'nap pods' for company employees have been springing up in recent years (I tested one in London), and low and behold, they have proven to increase, not limit, productivity.

What, then, of the four-day work week, which Jeremy Corbyn was widely ridiculed for proposing in the run up to the last general election? Not as mad as you might think. In summer 2019, Microsoft tested it out in its Japan offices. For the duration of the trial, the company reported a 40 per cent increase in productivity and, bonus, a 23 per cent reduction in electricity costs. A similar experiment has since been conducted in New Zealand, where a 20 per cent uptick in efficiency was observed.

In fact, the more you drill into the figures, the more it becomes clear that the countries around the world with the shortest working hours (Germany, Denmark Norway, the Netherlands) are actually among the most productive, certainly according to the World Economic Forum. "The average German worker is reported to be 27 per cent more productive than his or her British counterpart," its latest findings read. The Germans, depressingly, work an average of 26 hours a week, compared to 42.3 hours in the UK.

Putting aside our primal cry for rest, another enviable trait to have emerged from our inquiries was the Medditerran tendency to dine later in the evening than we Britons typically do. According to Laura Fowler, this approach reigns in Tel Aviv: "Locals there traditionally go out to dinner once the kids are in bed, and bars stay open as long as there are people drinking in them. Why close when everyone is having a good time?"

One Britishism, though, I think we can all agree on keeping is that which no other nation can compete on: proper, traditional pubs.

Our Franken-nation: a beautiful island of mountains, forest and beaches, about the size of South Africa, with the sunny climes of California. A population comparable to Iceland, with the healthcare system of France. Bicycle lanes to rival the Netherlands'. Hong Kong's zippy underground network, and internet as fast as Singapore's. Italian food, Swiss tap water and British pubs. We'll have Japan's bullet trains, thank you very much, as well, and its loos and its vending machines. We shall work less, like the Germans, and spend more time in saunas and the great outdoors, like the Finns.

Siestas will anchor our warm days, and as our deeply enriching lives draw to an end, we won't degenerate in nursing homes, but check into Digitas, get into bed and go to sleep.

What have we got right? What have we got thoroughly wrong? Nominate the traits you admire most from other countries and we'll publish the best of them.

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The anatomy of a perfect country what makes a nation great? - Telegraph.co.uk

‘Grey’s Anatomy’ Alum Katherine Heigl Shows Off Dramatic New ‘Do on Instagram – Showbiz Cheat Sheet

Katherine Heigl portrayed Dr. Isobel (Izzie) Stevens on the hit series Greys Anatomy for almost six seasons, abruptly exiting the show in 2010. The actress moved on to other acting projects in films such as 27 Dresses, The Big Wedding, and Unforgettable. The former Greys star has also appeared on several TV shows since her departure including State of Affairs, Suits, and Doubt.

Despite these numerous credits, diehard fans of the ABC medical drama will always think of her as the intelligent, kind-hearted Izzie with the trademark mane of blonde hair, though now shes sporting a much different look.

Before the Season 16 premiere, Greys Anatomy showrunner Krista Vernoff began floating hints of the return of a show alum, yet didnt give any specifics. Im trying to get someone back, she said,according to IMDb. Theres someone Im hoping will make an appearance this year, [but] its a real maybe. Im trying.

Naturally, fans weighed in on who the former cast member could be with guesses including Sarah Drew (April Kempner), Sara Ramirez (Callie Torres), and Sandra Oh, who played the legendary Cristina Yang. When Heigl was promoting the final season of Suits last year, she was asked if she would consider going back to do rounds at Grey Sloan Memorial.

Thats a tough one. I dont know, she said in July, as reported by Cinemablend. I almost feel like that would almost be distracting again to, sort of, what theyve done with that show in the seven years since I left, you know, and what thats become and what it is to the fans now. It must feel like it would just be kind of like, Yeah, we already let that go, you know? Why are you here?'

In September, Heigl posted a pic of herself showing off a sharply different hair color from her traditional blonde to dark brunette for her role of Tully Hart in the upcoming Netflix seriesFireflyLane, according to People.

If you havent caught my stories this will be a shock for you #tullyhart #FireflyLane #nextroleforthisgal, she captionedthe photoat the time, referring to her previous Instagram Story posts revealing the color-change process.

The series, set in the mid-1970s, is based on the book by Kristin Hannah that follows the relationship between central characters Kate Mularkey (played by Sarah Chalke) and Tully Hart (Heigl) that spans three decades. The release date for Firefly Lane has yet to be confirmed.

Earlier this week, Heigl was back on Instagramrevealing that her entire family had gotten new haircuts. While the actress and her 3-year-old son were willing to pose for the pic to debut their new dos, her daughtersAdalaide Marie Hope, 7, andNaleigh Mi-Eun, 11, were not.

Fresh cuts for the Kelleys, Heigl captioned a slideshow of several photos where she shows off a fresh new bob. The girls were nowhere to be found for these picsor theyre hiding cause they dont want to be in the picbut every one of us got our hairs done and we feel fine!

Heigl, who shares her three kids with husband Josh Kelley, added a note on the post that her daughters may want to keep in mind. PS. I will capture the girls cuts one way or another, the Firefly Lane star wrote. they cant hide forever.

The former Greys star proves in her pics that she can pull of any hairstyle!

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'Grey's Anatomy' Alum Katherine Heigl Shows Off Dramatic New 'Do on Instagram - Showbiz Cheat Sheet

Greys Anatomy Recap: Mergers and Divisions – Vulture

Greys Anatomy

Save the Last Dance for Me

Season 16 Episode 13

Editors Rating 2 stars **

Photo: Ali Goldstein/ABC

Ah, midseason Greys Anatomy. Its that time of year where there are some moments of gripping drama, but mostly episodes are laying track for big things to come toward the end of the season. Were treading water again, and in Save the Last Dance for Me you could really feel it.

Take the AmeliaLink paternity debacle (YES WE HAVE TO). Amelia, in all her maturity and non-tumor-ness (wait, remember when Greys blamed all of Amelias irrational actions on her tumor? But then they removed it and shes basically the same? LOL, so cute), has taken to avoiding Link altogether while they wait for paternity results. Poor Link is just wandering around like a sad puppy waiting to find out if hes going to be a father or not as is his right, by the way and Amelia is acting like this is all about her. Yes, of course that tracks, but that doesnt make it fun to watch. She calls Link for a meeting in the plant room and pretty much tells him that he needs to figure out what hes going to do if the baby ends up being Owens right that very minute. You said you love me, is that true? she asks. This is such manipulative bullshit because hi, hello, he can love her and also be upset that this baby isnt his. Both things could be true, and where is a sister or two to come talk some sense into this lady when you need one? She especially needs a patented Meredith Grey speech about not being so Amelia about things by the end of the episode, because just as we think were going to get the paternity results, Amelia texts Link and tells him she hasnt even run the test yet. She cant. She needs time. What about our time, Amelia?!

Speaking of things we have a lack of interest in: the Grey Sloan Merger 2.0. Thats right, guys, Catherine went ahead and bought Pac-North, and it and its employees are being absorbed into Grey Sloan. Theyll be weeding out the extra staff by good ol fashioned interviews with Tom Koracick, the Chief of Chiefs. Once again, Tom is reveling in his power: Maggie gets her job back, but shes going to be working under Teddy; Owen is going to get his job back but gets strung along the entire day; and Richard is offered his job because Catherine demands it. No one is happy about any of this and Richard storms out, refusing to be a piece in Catherines chess game. Hed rather quit than let her win. But the people wont stand for that! And by people I mean Jackson, Bailey, and Meredith.

Jackson, Bailey, and Meredith grab Owen and Richard and go marching into the conference room to confront Koracick. Theyre the Board, ya see! Theyre not going to let Tom rule this hospital, ya see! Theyre a family and they do things a certain way, YA SEE! I mean this is all nice and fun, but its very confusing to keep track of who is on the Board and who isnt and also who really has power at Grey Sloan? This all seems convenient, but Tom goes along with it because he knows theyre right: If they all walk out on him, Catherine will not be happy. If he goes along with their plan, he can remain Chief of Chiefs in both title and salary, and that is enough for him to agree to making Maggie and Teddy co-Chiefs of Cardio, making Alex and Cormac co-Chiefs of Peds, and no longer running the hospital with a his way or no way mentality. For those who have been wondering how on earth wed get all our doctors under one hospital roof again, you have your answer!

Not all is lost, dear Greys friends. There is one storyline that has me intrigued: The unsolvable case of Suzanne. Remember Suzanne? DeLucas patient who started getting sicker after a routine appendectomy and they cant figure out why. Shes getting much worse, and although DeLuca has set up the war room Bailey requested, they still have no answers. DeLuca tricks a master diagnostician into coming to Grey Sloan by telling her The Meredith Grey has requested the consult, which is mean DeLuca repeatedly describes it as luring her to Grey Sloan and seems to think that makes it better and I really need someone to tell that child that is is only making it worse but ultimately a good decision.

Welcome Dr. Riley, Greys Anatomys first deaf doctor. She has no time for DeLucas nonsense, which is always delightful. After Maggie has to operate on Suzanne because of fluid building around her heart, Dr. Riley has an extremely risky plan: They need to take Suzanne off all of her medication antibiotics, steroids, everything so that they can see if maybe her medication is blocking out a clue to whats really going on. Obviously, taking a sick woman who just had heart surgery off all medication is not advisable, like, at all, but Rileys the best and this is her best recommendation. DeLuca turns to Maggie for her opinion, but Maggie, who may be back in the OR but is definitely much more detached than weve ever seen her, simply says Rileys idea is reckless and a catastrophic mistake. People should be watching out for Maggie.

Alas! There is no time! In the end, DeLuca offers Suzanne Rileys plan. Its risky shes definitely going to get sicker and be in pain while they try this but theyre all out of options. Its Suzannes sister Hadley who puts up the biggest fight. Riley wins her over with an emotional speech about her own sisters, how one is her best friend and so she understands what shes asking Hadley to do. She tells Hadley that Suzannes immune system is completely compromised and with the medication all gone, the disease will finally be able to talk to Riley. This is the best shot they have at saving Suzannes life. Suzanne and Hadley agree to move forward with Dr. Rileys plan. DeLucas moved by Rileys speech and when he starts to tell Riley about his own sister, she stops him shes an only child. She made it up to get Hadley on board. Dang, Dr. Riley. Thats cold but also Im impressed.

Well, I guess its time to talk about the Alex update: Jo confides in Amelia that Alex, still with his family, hasnt been taking her phone calls and told her hes going through something. Are they really going to have Alex just leave his wife and never return? We should reserve judgment until it plays itself out, but currently its all feeling a little too Izzie Stevens for me.

Is there really any hope for a reconciliation between Richard and Catherine at this point? Jackson seems to think so, well, until he sits down with Richard who compares Catherine to Godzilla stomping all over Tokyo. Im no expert, but that doesnt seem like a good sign for mending fences.

Wow, wow, wow. Is this the end of Schmitt and Nico? Nicos annoyed that Schmitt has basically moved into his place, just as Schmitt meets an older patient dying of cancer and her husband, who are the loves of each others lives. Former ballroom dancers, Schmitt helps Norman share one last dance with Irene in the hospital cafeteria. Its lovely. But it also makes Schmitt think about his relationship. He wants more than just great sex. He wants a real partner. It might not be Nico.

Meredith also has a big reaction to Norman and Irene dancing in the cafeteria: She realizes that back in the day, it wouldve been her organizing that dance. She wonders when she stopped being such a romantic, and what that says about her relationship with DeLuca. The two of them are sleeping together again, but she wonders what it means that when he sort-of-dumped her, she barely felt anything but annoyance. Is DeLuca out and Cormac in? Did Cristina Yang truly know best?

Wait. Are Bailey and Ben going to adopt 17-year-old foster kid Joey who came in from Station 19? Theyre totally going to adopt him.

Speaking of Station 19: Whats with all the crossover stuff? I watch both shows and even I find it all to be a little too much. Next week: Bear at
tack crossover! I mean, thats hilarious, but still.

Keep up with all the drama of your favorite shows!

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Greys Anatomy Recap: Mergers and Divisions - Vulture

Can Animal Dissection Be Replaced? The Cruelty-Free Alternatives Paving the Way – LIVEKINDLY

Educational animal dissection is a controversial topic. Proponents defend its educational merit, while critics question the ethics, environmental impact, and overall necessity of the practice. But what is the reality of animal dissection, and is there a cruelty-free option?

Dissection, in general, involves the dismembering of a deceased animal or plant to study its internal and anatomical structure. In the U.S., the educational dissection of smaller animals typically takes place during middle and high school. According to Animalearn, which provides humane education resources to educators, around six million vertebrate animals are dissected in U.S. high schools alone.

Many critics of dissection focus on ethical, animal welfare considerationssuch as the number of individual animal lives lost. However, there is also a broader ecological impact caused by removing animals from their habitats. There is also the issue of human health. Animals for dissection can be preserved in chemicals such as formaldehyde, which the Environment Protection Agency classifies as a probable human carcinogen.

The most commonly dissected animal by middle and high school students is the frog. But other species include rats, mice, worms, cats, dogs, rabbits, fish, and fetal pigs.

While procuring these creatures in the wild can negatively impact their native habitat, most come from companies that specialize in supplying animals via breeding facilities. Some slaughterhouses, pounds, animal shelters, and pet stores sell animals to these biological supply companies. Including lost or stolen former companion animals.

Many people, both supporters and critics, emphasize the rights of students to choose or refuse to take part in dissection. However, according to the paper Dissection and Choice in the Science Classroom (2012), teachers do not always offer pupils this choice.

While 18 U.S. states, including California, allow the student to opt-out of dissections without penalizing them, this research suggests that even if given the choice, many students may feel too intimidated to do so. Some have reported feeling pressured and wary of social stigma.

In California, legislation may result in a total ban on all school-level educational dissection. Last year, assembly member Ash Kalra introduced AB-1586the Replacing Animals in Science Education (RAISE) Act. This bill aims to replace animal dissections with modern, humane alternatives.

Learning about anatomy in schools is important scientific pedagogy but dissection presents a significant impact on the environment and our fragile ecosystems. Advancements in educational technology have expanded access to this important scientific instructional methodology without having to rely on animals, Kalra said in a statement.

With the development of technological alternatives, virtual and computer-based science teaching practicum offer more humane teaching methods that help to better prepare students for higher education and careers in science, added Kalra.

The bill was co-sponsored by several non-profit organizations, including the Physicians Committee for Responsible Medicine (PCRM), Social Compassion in Legislation, and PETA (People for the Ethical Treatment of Animals). The National Hispanic Medical Association, the Humane Education Coalition, Center for Healthcare Education, and the United Federation of Teachers Humane Education Committee also support the bill.

Support for alternative teaching methods comes from a wide variety of sources, including teachers and academics. Some studies have suggested that dissecting animals can actually desensitize students to the sanctity of life, and potentially foster cruelty towards animals.

The fact is, we do not need to put our young people through this. There is a better way, and California can and should move to the more modern and accepted use of digital dissection resources, said Judie Mancuso, CEO of Social Compassion in Legislation.

There is an increasing number of alternative teaching methods, ranging from hyper-realistic synthetic animals to software and apps. Tampa-based company SynDaver specializes in sophisticated, synthetic models for dissection. These extremely lifelike models are used for education, surgical simulation, and testing medical devices. According to SynDaver, this validated technology can effectively replace human patients, cadavers, and animals.

The companys SynFrogs are reusable and mimic the properties of a live, female frogthe most commonly dissected animal by middle and high school students. Last year, J.W. Mitchell High School in New Port Richey, Florida, became the first in the world to use SynFrogs.

Theres no longer any need to harm real frogs for the sake of enhancing the educational experience, says SynDaver. In addition to eliminating the ethical concerns of sacrificing living animals to teach comparative anatomy, SynFrog is a better option for students because it does not expose them to hazardous chemicals, like formaldehyde and formalin.

SynFrogs cost $150 each, which is considerably more than animal-based dissection. However, synthetic alternatives are also reusable, which will save schools money long term and is far less wasteful.

Computer technology presents another alternative for traditional educational dissection. Indian company Designmate developed Froggipedia as an ethical, realistic, 3D alternative. The app allows students to explore the life cycle and complex anatomy of the frog and has received praise from teachers and parents alike.

Norecopas Sniffy the Virtual Rat allows students to explore operant psychology using virtual simulation. The company says its product gives students a virtual laboratory experience without using a real laboratory rat. The simulation closely resembles many of the experiments discussed in learning textbooks.

More high-tech software can combine x-ray, ultrasound, and MRI imaging to create a virtual anatomy display. Stanford Medical School and at New York University use similar technology, and at NYU, students can wear 3D glasses to explore the virtual anatomical display.

Interactive models are another alternative to educational animal dissection. Companies such as AnatomyStuff produce 3D, anatomically correct models. These models are also common when studying human biology, and mock-ups of individual body parts and systems are relatively widespread in classrooms.

Anatomy in Clay allows students to build the body systems of humans and animals out of clay on model skeletons. The company promotes hands-on learning as the most efficient way of reaching visual, tactile, and kinesthetic learners all at once.

Denoyer Gepperts Great American Bullfrog is a large-scale model of the animal with individually numbered parts. The circulatory, reproductive, and other systems can be separately dissected. The company also produces models of plants and large wall charts, another alternative to live dissection.

The Biology Chart Series includes detailed charts of a dissected frog, perch, crayfish, grasshopper, and earthworm. There are also countless books on various anatomy available to students, including interactive editions.

Knitting artist Emily Stoneking has created anatomically correct knitted scenes and DIY kits through her company, aKNITomy.

The Vermont-based company creates rats, bats, pigs, frogs, earthworms, and even humans out of textiles. The range of knitted scenes are precise, anatomically correct, and make effective educational displays and projects.

Stoneking recently told Mother Nature Network,I decided to incorporate my love of vintage anatomical illustrations and make the animals look like dissection models.

I am beginning to move more toward two-dimensional, human-based artwork that is very strongly influenced by 19th-century anatomical illustrations. I am fascinated by the history of medicine, and I just have always loved the artwork associated with that, continued Stoneking.

She sells finished items for display, as wel
l as pattern kits for people to knit at home. Stoneking also sells a combined pattern collection that includes several best-selling items.

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Can Animal Dissection Be Replaced? The Cruelty-Free Alternatives Paving the Way

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Traditional animal dissection is a controversial subject, and some believe these cruelty-free, educational alternatives are more effective.

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Can Animal Dissection Be Replaced? The Cruelty-Free Alternatives Paving the Way - LIVEKINDLY

‘Grey’s Anatomy’: Why Amelia Won’t Reveal the Father of Her Baby – Showbiz Cheat Sheet

[Spoiler alert: Greys Anatomy Season 16.] Sorry, Greys Anatomy fans the messy triangle between Owen Hunt (Kevin McKidd), Amelia Shepherd (Caterina Scorsone), and Atticus Link Lincoln (Chris Carmack) is far from over. For weeks, viewers as well as our beloved characters have been stressed about the father of Amelias child. However, in the 13th episode titled Save the Last Dance for Me the neurosurgeon decided against a paternity test. So why didnt Amelia reveal the father of her baby on Greys Anatomy? Theres more to this story than meets the eye.

In the Greys Anatomy Season 16 premiere titled Nothing Left to Cling To Amelia learns about her pregnancy after a visit with Carina DeLuca (Stefania Spampinato). At this point, Amelia and Owen are broken up and she is dating Link. Meanwhile, Owen and Teddy (Kim Raver) are gearing up to raise a family together.

Regardless, by the time the episode ends, the paternity of Amelias baby is questioned. But as season 16 continues, its clear Amelia believes the father is Link. Then when she tells him the news, Link is excited and ready to dive in. However, that feeling doesnt last for long.

In the Greys Anatomy Season 16 fall finale titled Lets All Go to the Bar Amelia gets an ultrasound. And it turns out, she is 24 weeks pregnant, rather than 20. So its possible Amelias baby is Owens and not Links.

Eventually, Amelia gathers up the courage to tell Link the truth. That said, she doesnt want to get a paternity test since she made her decision and wants to be with Link. At first, Link is fine with Amelias decision. But he reconsiders and wants to take the test.

Then in episode 13, Amelia puts her foot down. She doesnt want to take the test. As Link is stressing out in the plant room, Amelia texts her boyfriend. Im sorry, she writes. I didnt run the test. I need time.

Link stares at his phone in disbelief.

When speaking with Variety on Feb. 13, Greys Anatomy showrunner, Krista Vernoff, delved into the drama surrounding Amelias baby, explaining why the character is having such a difficult time facing the paternity of her unborn child.

She is not going to play by anyone elses rules, Vernoff said. And she is protecting her own heart and her own pregnancy and her own sanity at whatever cost.

The showrunner later added: She is figuring out what it is on her own terms. This character has learned how to listen to her own body and shes been through one very traumatic pregnancy. And the feelings that came up in her body were not feelings that she wants to navigate during this pregnancy. So shes looking to take care of herself and her baby.

But despite isolating herself from Link at this moment, Vernoff said Amelia isnt alone and will likely find refuge in her sisters, Meredith Grey (Ellen Pompeo) and Maggie Pierce (Kelly McCreary).

Vernoff also confirmed the father of Amelias baby wont be revealed for some time. I know the fans want an answer as to whose baby this is, and theyre not going to get it as soon as they wish for it, she said.

Greys Anatomy fans have already expressed their frustrations in regards to Amelias story storyline. Now, viewers can expect more in the upcoming weeks but thats sort of the point.

The way weve written this story, from week to week, Im sort of on her side, and then Im on Links side, and then I dont really know, she said. I think it sparks a lot of conversation of, Is she being selfish to not find out or is he being selfish to want to know? It is kind of the question that we ask.

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'Grey's Anatomy': Why Amelia Won't Reveal the Father of Her Baby - Showbiz Cheat Sheet