Sy Borgman: The new Cyborg in town! – Animated Times

The Harley Quinn animated series has proven time and again that there exists competition between the domestic franchises housed under the D.C. Universe. The characters of the DCEU have been portrayed in the animated series under the comic book houses banner and have lived up to fans expectations. A debate went down recently when The Harley Quinn animated series introduced its version of the Cyborg.

In a quest to rescue Poison Ivy from the clutches of Scarecrow, Harley Quinn introduces her landlord to the team. Sy Borgman is a retired U.S. agent who uses a wheelchair with some cybernetic enhancements. His name was the giveaway for the fans that there has to be a story behind the character and reason why the character is an ally to Quinn. It is later revealed that the old retired agent was a part of the special cyborg program.

Vic Stone has shown the audience that he is the one who is suited to play the Cyborg. Be it the kid-friendly one in Teen Titans Go! Or the badass half-human and half-god in Justice League, Stone has always proven to be the most worthy. Currently, he is a hybrid New God and one-person wrecking ball with tech made from the Mother Box.

In the animated series, when Harley Quinn and gang break into Ivys psyche and rescue her from Scarecrow, they realize that they do not have a transport chase him down.

Though he repeatedly falls asleep due to narcolepsy, we are sure is coming back time and again! He is now probably a permanent member of the Quinn gang, and he may show up sometime in the DCEU as well!

Source: CBR

We have an excellent team with diverse strengths at Blu Saviors LLP. Our goal is to bring a revolution into the world's entrepreneurial ecosystem through the successful development of brilliant start-up ideas. With our affordable, quality services we aim to expand existing start-ups and businesses.https://blusaviors.com/

Visit link:

Sy Borgman: The new Cyborg in town! - Animated Times

See Henry Cavill With Black Superman Costume & Beard In New Image – Heroic Hollywood

Along with the premiere of the first teaser forDoom Patrol,DC Universe also debuted a collection of character posters for each of the members of perhaps the strangest team of characters to be adapted in live-action form for DC Comics.

In particular, these new character posters highlight Timothy Dalton's The Chief, Diane Guerrero's Crazy Jane, Joivan Wade's Cyborg, April Bowlby's Elasti-Woman, Matt Bomer's Negative Man and Brendan Fraser's Robotman. These posters each follow unique designs that reflect the nature of each character and tease unique personalities amongst the group as well.

You can start the gallery of new posters by clicking "Next".

Which of theseDoom Patrolposters is your favorite? Are you excited to see what the cast brings to these roles? Sound off in the comments below, and be sure to continue following Heroic Hollywood for all the latest news in the DC Universe.

Doom Patrol is a reimagining of one of DCs strangest group of outcast Super Heroes which includes: Matt Bomer as Larry Trainor/Negative Man, Brendan Fraser as Cliff Steele/Robotman, April Bowlby as Elasti-Woman, Diane Guerrero as Crazy Jane, Joivan Wade as Victor Stone/Cyborg and Timothy Dalton as Dr. Niles Caulder/The Chief.

Here is the synopsis for the show:

Doom Patrolwill find the reluctant heroes in a place they never expected to be, called to action by Cyborg, who comes to them with a mission hard to refuse, but with a warning that is hard to ignore: their lives will never, ever be the same.

Doom Patrolwill premiere on February 15, 2019 exclusively on DC Universe.

Read more:

See Henry Cavill With Black Superman Costume & Beard In New Image - Heroic Hollywood

Grievous began to realize far too late – Dork Side of the Force

After the death of Count Dooku, General Grievous began to suspect his time in this master plan was coming to an end. The Star Wars villain didnt have much time to turn things around in his favor.

Narrowly escaping the Invisible hand in an escape pod, General Grievous speaks via hologram with Darth Sidious. Sidious tells him the end of the war is in sight.

But the loss of Count Dooku?responds Grievous.

His death was a necessary loss. Soon I will have a new apprentice, one far younger and more powerful , boasts Sidious.

Sidious then instructs the Separatists to move to Mustafar. The droid general heads to Utapau to rendezvous with the droid army sanctioned there. Grievous knows something is up. Sidious was not not even upset about the death of Dooku.

Dooku: apprentice of Sidious, mentor to Grievous and Leader of the Seperatist Droid army.

With Dooku gone, what was planned for Grievous? Was the cyborg still valuable? How long until it was time for him to be removed from this master plan? Grievous begins to realize this Dark Lord of the Sith is willing and able to cut out anybody no longer valuable in his quest for power. Use them up and then toss them away.

Grievous arrives on Utapau and instructs the Separatists to move to Mustafar. With reluctance, they abide. Kenobi, emerges and faces Grievous in a fierce duel, before Grievous flees in his wheel bike. A wild pursuit ensues until Kenobi is able climb aboard the bike and crash.

The two come to blows. An all out brawl, cheap shots and all. Kicking, hitting, punching, pulling and throwing. Kenobi manages to rip open Grievous armor plates, revealing Grievous gut-sack. Grievous angrily tosses Kenobi off a ledge. The Jedi manages just barely to utilize the force and hold on for dear life.

The force is with him, as he calls the Generals blaster to him and fires shot after shot as the cyborg menaces toward him. Grievous is aflame, literally on fire. Burning up inside.

The flames explode Grievous and the cyborg collapses.

So uncivilized, Kenobi comments.

That comment could describe the whole conflict known as the Clone Wars and the galactic Civil War to come.

What if things could have been different for Grievous? Why did the cyborg not flee, as was typical of Grievous?GeneralGrievous will runand hide ashe always does:Hesa coward. as stated by Mace Windu in ROTS. What made this time any different? General Grievous may have thought that Darth Sidious would find him anywhere and anyhow, anyway. Which he probably would have; certainly Vader would have been sent to take care of any leftovers from the Confederacy after finishing off the rest of the Separatists. Or maybe Grievous had doubts about whether the Dark Lord would actually cut him out completely. He could have assumed that a commanding spot would still await him once the war had ended.

Whether he realized what was in store for him or not, it was far too late. General Grievous became backed into a corner. It was in fact Sidious acting as Chancellor Palpatine who gave Anakin the whereabouts so that the Jedi council could send troops to Utapau to pursue Grievous. In addition to the Republic hunting him, Sidious no longer needed him. When a Sith Lord wants you gone, your gone.But alas, the one time General Grievous chooses fight instead of flight, it costs him his life. So uncivilized indeed.

See the original post:

Grievous began to realize far too late - Dork Side of the Force

7 Dance Performances to See in N.Y.C. This Weekend – The New York Times

Our guide to dance performances happening this weekend and in the week ahead.

RONALD K. BROWN/EVIDENCE at the Joyce Theater (Feb. 25-26, 7:30 p.m.; Feb. 27-28, 8 p.m.; through March 1). For decades, Brown has created profound choreography that grapples with life and faith, and his exuberant blend of contemporary and African dance can feel like physical prayer. He celebrates his companys 35th anniversary with a program that includes High Life (2000), which begins with a depiction of a slave auction; Grace (2000), a work made for the Alvin Ailey company in which a woman in white welcomes people to heaven; and Mercy, the companion piece to Grace, which premiered last year and is set to music by Meshell Ndegeocello. Wednesdays gala performance also includes an excerpt from Open Door with the Ailey dancers Linda Celeste Sims and Glenn Allen Sims. 212-242-0800, joyce.org

FLORENTINA HOLZINGER at N.Y.U. Skirball Center for the Performing Arts (Feb. 22-23, 7:30 p.m.). The 1928 ballet Apollo, about the Greek god and his muses, is a neoclassical gem that put George Balanchine on the map. In Apollon, this Austrian choreographer takes that work as a reference point and gives it a brash, feminist twist. Five women with a spectrum of body types, at times topless, critique the myth of the ideal feminine body as perpetuated by ballet. They do so through a series of sideshow acts and wacky scenarios an occult fitness studio, a cyborg bullfight drawing on, among other things, Holzingers fascination with Coney Islands colorful past.212-998-4941, nyuskirball.org

SARA JULI at Dixon Place (Feb. 21-22 and 27, 7:30 p.m.; Feb. 28, 7 p.m.). Within the setting of a pink, overly cheery bathroom, Juli dons curlers and a frilly robe for her new solo dance-theater piece, Burnt Out Wife, a comedic autobiographical reflection on a long list of marital issues (and grievances) like monogamy, loneliness and intimacy. With punch lines aplenty, the show, co-presented by the American Dance Festival, has the feeling of a stand-up routine. The accompanying frantic gestures enhance Julis take on the roller coaster of being in a relationship. 212-219-0736, dixonplace.org

[Read about the events that our other critics have chosen for the week ahead.]

JAEWOO JUNG at the 92nd Street Y (Feb. 21, 8 p.m.; Feb. 22, 4 and 8 p.m.). The 92Ys Harkness Dance Festival kicks off with Perfect Skill, a work by this Korean choreographer in collaboration with Braveman, the dance collective he co-founded in 2017. The piece occurs largely in the dark, with bodies or parts of them illuminated by flashlights. At the center of Perfect Skill is a male duet, performed naked, which is more farcical than fanciful. Also on the program is the solo Uninhabited Island, an almost vaudevillian work featuring Jung and a small table that becomes both support and nemesis as he is flung around by unseen forces.212-415-5500, 92y.org

CHERYLYN LAVAGNINO at the DiMenna Center for Classical Music (Feb. 25-26, 7:30 p.m.). Edward Hoppers paintings captured a romantic loneliness, finding ominous beauty in scenes of collective isolation. In Tales of Hopper (2019), Lavagnino brings those scenes to life and puts their melancholy in motion to original music by Martin Bresnick. Performances of 2016s Veiled, a dance for six women that depicts, as the choreographer puts it, women who carry themselves with strength and dignity through an unjust world, and an excerpt from 2012s Triptych are also on the bill. dimennacenter.org/calendar

NEW YORK CITY BALLET at the David H. Koch Theater (Feb. 21, 8 p.m.; Feb. 22, 2 and 8 p.m.; Feb. 23, 3 p.m.; Feb. 25-27, 7:30 p.m.; through March 1). Performances of Peter Martinss Swan Lake continue through Sunday. Then the company introduces two programs that it believes best represent its identity: Classic NYCB I, on Tuesday, consists of Haieff Divertimento and Episodes by George Balanchine, Concertino by Jerome Robbins and the lovely Rodeo: Four Dance Episodes by Justin Peck. The Classic NYCB II bill on Wednesday and Feb. 27 features Robbinss In G Major, Christopher Wheeldons DGV: Danse Grande Vitesse and Pecks new work, set to music by Nico Muhly. 212-496-0600, nycballet.com

WORKS AND PROCESS at the Solomon R. Guggenheim Museum (Feb. 23, 3 and 7:30 p.m.; Feb. 24, 7:30 p.m.). When it premiered in 1877, the ballet La Bayadre was on trend in exoticizing India, where the story of the captured temple dancer Nikiya takes place. Today, its setting and characters are considered problematic. For his new production of the tale, the former American Ballet Theater star and current Pennsylvania Ballet artistic director Angel Corella addresses those issues and offers excerpts (on Sunday). On Monday, the dancer and choreographer Caleb Teicher presents a preview of his new work devoted to swing dance, complete with Lindy Hoppers and big-band backup. 212-423-3575, worksandprocess.org

Read the original:

7 Dance Performances to See in N.Y.C. This Weekend - The New York Times

Doom Patrol Season 2 Brings In a New Character Having Cyborg Connection! Find Out Who He/She Is! – Top Buzz Times

Karen Obilom (Games People Play) will appear in a repetitive job for the second period of DC Universe/HBO Max series, Doom Patrol. She portrays Roni Evers, a character who is depicted as a military veteran with a puzzling past. One that may have further associations with specific individuals from the group. Evers will meet Joivan Wades character Vic Stone/Cyborg while both are in participation for a PTSD bolster gathering.

Composed by Jeremy Carver, Doom Patrol is dependent on the DC comic book characters. It is initially made by Arnold Drake, Bob Haney, and Bruno Premiani. It recounts to the account of an improbable gathering of scarred and deformed legends. They all are united by The Chief. Together, they find a reestablished reason through their gallant endeavors.

Doom Patrol is a side project of the show Titans. It is right now recording its subsequent season, which will air on both DC Universe and HBO Max. There are not many insights regarding the Season 2 dispatch date at the hour of writing. Normally, Season 1 will be accessible simultaneously on HBO Max once Season 2 debuts in 2020.

Gushing now on DC Universe, Doom Patrol stars Brendan Fraser as Cliff Steele. It also includes Matt Bomer as Larry Trainor, Diana Guerrero as Crazy Jane, Alan Tudyk as Mr. No one, April Bowlby as Rita Farr, Joivan Wade as Vic Stone and Timothy Dalton as Niles Caulder.

Dalton previously confirmed that Dorothy would show up on Doom Patrol shortly after the principal scene debuted a year ago. She made a short appearance in the main season finale (as observed above). However, watchers never observed her face. As indicated by her official depiction, Niles adores her without question and has experienced incredible penance to secure her. And the world, from her unique capacities. Since she is never again covered up. Niles will go to much more noteworthy lengths to secure her.

Roni Evers seems like a sex swap of Ron Evers, a companion to Victor Stone who originally showed up in the pages of New Teen Titans during the mid-80s. Made up for lost time in the existence of wrongdoing, Evers attempted to explode STAR Labs and tumbled to his demise.

Doom Patrol season 2 will be accessible to stream on both DC Universe and HBO Max in the not so distant future.

Link:

Doom Patrol Season 2 Brings In a New Character Having Cyborg Connection! Find Out Who He/She Is! - Top Buzz Times

Fighters and Boxers React to Tyson Fury vs. Deontay Wilder – Heavy.com

GettyTyson Fury lands a punch on Deontay Wilder during their rematch.

On Saturday, February 22, the sporting world finally watched two of the best heavyweight boxers battle it out in a rematch. Tyson Gypsy King Fury competed against Deontay The Bronze Bomber Wilder in an exciting bout that ended with the Gypsy King as the victor.

Their first match last all twelve rounds, and it was declared a draw. That wasnt the case this time around. Fury dominated the fight, knocking The Bronze Bomber down multiple times and winning the fight by TKO after Wilders corner through in the towel during the seventh round.

With the match between the two boxing titans so highly anticipated, many fighters watched the event. They also took to Twitter to share their thoughts on the bout.

Follow the Heavy on UFC Facebook page for the latest breaking news, rumors and content!

Mike Tyson is seen celebrating after Fury stops Wilder.

Current Bellator Womens Featherweight Champion Cris Cyborg tweeted, Keep your head up [Deontay Wilder].

Current UFC Heavyweight Champion Stipe Miocic tweeted, Congrats [Tyson Fury]. Id love to sin Sweet Caroline in the ring. Lets do this.

Boxing prodigy Ryan Garcia tweeted, I dont give a care! FURY ACHIEVEED GREATNESS TODAY and i picked him to lose!!! Thats just props right there he fought the perfect fight all love [Tyson Fury].

Olympic gold medalist boxer and multiple promotional champion Claressa Shields tweeted, Damn congrats [Tyson Fury]! and [Deontay Wilder] you still the champ! and a hell of a fighter.

Top-ranked UFC heavyweight Francis Ngannous tweet reads, Lets make it happen, [Ngannou vs. Fury].

Former interim UFC Lightweight Champion Dustin Poirier tweeted, Fury beats [Anthony Joshua] too dont [tag] me.

The Gypsy King entered the boxing ring on February 22 as an undefeated fighter, and he left with his 0 in tact. Fury dominated The Bronze Bomber for most of the match, landing relentless punches and knocking him down multiple times. With the victory over Wilder, the Gypsy Kings overall professional record has improved to 30-0-1.

Deontay Wilder suffered his first ever pro boxing defeat to the hands of Fury. With the loss, The Bronze Bombers record has fallen to 42-1-1.A trilogy fight between the two men may happen down the line, but presumably Wilder will have earn his way back to that shot.

For Fury, a match with Anthony Joshua is what fans around the world are clamoring for.

READ NEXT: Tyson Fury Carried Out on Throne Wearing Crown For Deontay Wilder Fight [WATCH]

View original post here:

Fighters and Boxers React to Tyson Fury vs. Deontay Wilder - Heavy.com

Sunway University Researchers Recognised with the Vice-Chancellor’s Research Award – QS WOW News

In its aim towards becoming the countrys international education hub, Sunway University is moving forward in its pursuit of excellence not only in academia but also through innovative research.

At the end of last year, four Sunway University researchers were recognised with the Vice-Chancellors Research Award. The recipients were; Associate Professor Dr Yong Min Hooi from the Department of Psychology who received the Special Research Award, Professor Saidur Rahman of the Research Centre for Nano-Materials and Energy Technology with the Award for Achievement in Research, Dr Ayaz Anwar of the Department of Biological Sciences and Dr Hassanudin Mohd Thas Thaker from the Department of Economics and Finance who each received the Award for Achievement in Research for Early Career Researcher.

Associate Professor Dr Yong Min Hoois research focusses on ageing, specifically, executive function and social cognition in older adults. Dr Yong received the Long-Term Research Grant Scheme (LRGS) from the Ministry of Education Malaysia, amounting to RM2.47 million for a 5-year research on Successful ageing: Evidence-based interventions to delay ageing-related decline. This is first single largest grant received in the history of Sunway University. The five-year term from 1 December 2019, scheduled to be completed by 30 November 2024, is categorised under the Aging cluster within Health research cluster and governed under the Sunway Universitys Research Ethics Committee.

Dr Yong previously received various grants from the Newton-Ungku Omar Fund from British Council and the Malaysian Industry-Government Group for High Technology (MIGHT), Arts and Humanities Research Council UK, and Fundamental Research Grant Scheme (FRGS) from Ministry of Higher Education.

Professor Saidur Rahman is Head of the Research Centre for Nano-Materials and Energy Technology. His research focus is in the area of emerging nano-materials, applications in harvesting and storing of solar energy. He has been recognised as a highly cited researcher, listed as the top 1% researchers for most cited documents in his research field of nanofluids for the last 6 years (2014-2019).

Dr Ayaz Anwars current research projects focus on nanomedicine and medicinal chemistry for the development of antimicrobial chemotherapy. His research on silver nanoparticles targeting brain eating amoeba gained international coverage and was featured in the New York Times.

Dr Hassanudin Mohd Thas Thaker research focus in Islamic banking and finance, real estate finance, financial markets, derivatives, and economics has been recognised internationally, earning him the Emerald Literati award in 2016.

Sunway University has 9 research centres and one research group under its roof where research across various fields of study is encouraged.

Go here to see the original:
Sunway University Researchers Recognised with the Vice-Chancellor's Research Award - QS WOW News

Sleuths Uncover Web of Research Fraud in 400+ Papers From China – The Wire

Elisabeth Bik, the microbiologist and research integrity consultant noted for unearthing evidence of research misconduct, tweeted on February 21that she and some others had uncovered over 400 scientific papers that all share a very similar title layout, graph layout, and (most importantly) the same Western blot layout indicating an organised web of potential fraud. She also expressed concern that there might be hundreds of papers more, and that she and her collaborators may just have spotted the obviously fraudulent ones.

Western blotting is a technique that microbiologists employ to identify the proteins present in a tissue sample. As an analytical technique involving real-world materials, no two images of western blots are supposed to look alike, and similarities suggest the image may have been manipulated, inadvertently or otherwise.

Guided by this and similar giveaways, Bik, @SmutClyde, @mortenoxe and @TigerBB8 (all Twitter handles of unidentified persons), report as written by Bik in ablog post that the Western blot bands in all 400+ papers are all very regularly spaced and have a smooth appearance in the shape of a dumbbell or tadpole, without any of the usual smudges or stains. All bands are placed on similar looking backgrounds, suggesting they were copy-pasted from other sources or computer generated.

Bik also notes that most of the papers, though not all, were published in only six journals: Artificial Cells Nanomedicine and Biotechnology,Journal of Cellular Biochemistry,Biomedicine & Pharmacotherapy,Experimental and Molecular Pathology,Journal of Cellular Physiology, andCellular Physiology and Biochemistry, all maintained reputed publishers and importantly all of them peer-reviewed.

As a result, the discovery of the problem papers has prompted concerns about the ability of peer-review to check research misconduct in the scientific community.

Indeed, when Bik writes, Finding these fabricated images should not rely solely on the work of unpaid volunteers, she evidently means herself and her collaborators but her words also apply to peer-reviewers, who are unpaid for their work and often lack both the resources and the inclination to investigate each paper in close detail. As a result, peer-review is often not the insurmountable defence some proclaim it to be, nor are peer-reviewed journals as free of bogus science as they claim to be.

As Madhusudhan Raman, a postdoctoral scholar at the Tata Institute of Fundamental Research, Mumbai,wrote inThe Wire, any attempt to radically change the nature of peer-review must necessarily be accompanied by a change in the way the referees are compensated for their time and effort, especially within academia.

A PubPeer user who goes by Indigofera Tanganyikensis first identified the problem in two papers (thisandthis) both published by Chinese researchers. On February 17 this year, a little under a week before Bik published her blog post, two American researchers Jennifer A. Byrne and Jana Christopher published an articlediscussing similar research misconduct based on 17 papers they had discovered.

According to Bik, As it turns out, Byrne and Christophers publication describes the exact same set of papers that our small team of image forensics detectives had been working on in the past month.

These sleuths, as @SmutClydewrote on Leonid Schneiders blog, believe they have stumbled upon at least one paper mill. To quote (selectively) from Biks post,

A paper mill is a shady company that produces scientific papers on demand. They sell these papers to [people] who do not have any time in their educational program to actually do research. Authorships on ready-to-submit or already-accepted papers are sold to medical students for hefty amounts. Whether or not the experiments described in these papers has actually been performed is not clear. Some of these paper mills might have laboratories producing actual images or results, but such images might be sold to multiple authors to represent different experiments. Thus, the data included in these papers is often falsified or fabricated.

The mills seem to have been hired by Chinese clinicians affiliated to various medical colleges and hospitals in China (234 of the 400+ papers have been authored by people affiliated to institutions in Shandong province). The papers were all published between 2016 and 2020. @SmutClyde wrote that after they publicised their findings, including thedataset of papers they had identified as potentially fraudulent (and which they continue to update), an author of one of the papers wrote in:

Being as low as grains of dust of the world, countless junior doctors, including those younger [than] me, look down upon the act of faking papers. But the system in China is just like that, you cant really fight against it. Without papers, you dont get promotion; without a promotion, you can hardly feed your family. I also want to have some time to do scientific research, but its impossible. During the day, I have outpatient surgeries; after work, I have to take care of my kids. I have only a little bit time to myself after 10 pm, but this is far from being enough because scientific research demands big trunks of time. The current environment in China is like that.

Considering how the peer-review of all of those journals have failed, what the detectives have found effectively represents a large volume of unscientific data entering the scientific literature, funnelled predominantly by Chinese researchers who probably hired a paper mill to help meet the publishing requirements set by their respective institutions. Bik wrote that it is of great concern to see that this specific paper mill has successfully infected particular journals and that it is very alarming to see that journal editors do not appear to have noticed the similarities between dozens of papers published in their journals.

This said, the note from the unnamed Chinese author indicates the source of the problem is hardly new or even confined to China.

For example, until Prakash Javadekar, then the Union human resource development minister, said in mid-2017 that college teachers would not be required to undertake research to qualify for promotions, people who had not trained for research and have since been embedded in environments not properly equipped to support research were forced to conduct research, and publish papers.

Javadekar is to be loudly applauded and congratulated for taking this measure,Pushkar wrote forThe Wireat the time. The research requirement in the [Academic Performance Indicators] for college teachers was a travesty. All that it achieved was a proliferation of fake journals for college teachers to publish in.

Indeed, India has come to be known the fake journals capital of the world, partly as a result of requiring people who cannot undertake research to undertake research, and partly because research productivity has become one of the core measures of determining whether a country is a scientific superpower.

For another example, the journalNaturereportedthat Pakistans research output increased the most among all countries in the world by 21% in 2018, a feat that it dubbed a phenomenal success. However, as Anjum Altaf, former provost of Karachis Habib University and a famous teacher, subsequentlytoldThe Wire, The volume of third-rate publications in Pakistan has increased greatly simply because [Pakistans Higher Education Commission] introduced a tenure-track system and required publications for promotion.

See more here:
Sleuths Uncover Web of Research Fraud in 400+ Papers From China - The Wire

Medical industry partly to blame for Paltrow’s horrible ‘Goop Lab’ – Press of Atlantic City

In the past few years, as a surgeon, I have become increasingly aware of the scourge of the wellness industry. I am seeing patients who opt for diets, supplements or magical therapies instead of the less seductive though scientifically grounded medicine I have to offer. Like everyone else, I too am constantly bombarded with messages in advertisements and from well-meaning friends as to how this diet or that vitamin is the key to health, longevity, beauty and status.

At the moment, every time I turn on Netflix The Goop Lab appears as a show that I might enjoy watching. Given that Goop exists on a platform of misinformation, privilege and anti-science rhetoric, its safe to say that as a surgeon and health communicator I will not be contributing to actress Gwyneth Paltrows growing wealth by watching her pseudoscience.

The growth of Goop and of the multitrillion-dollar wellness industry is cause for concern. On the surface, it looks full of promise and hope. Dig just a little deeper, beyond the claims of all-natural miracles the energy healing, the cold therapy, the anti-aging treatments and what we find is at best a waste of money and at worst harmful methods that actually compromise your health. Research has shown that for those with cancer, using alternative therapies such as homeopathy or specialized diets led to people opting away from proven treatments and an increased risk of dying from that cancer. Make no mistake: What wellness sells is by no means harmless.

For doctors such as myself, the rise of this brand of wellness is distressing. However, medicine as a profession and a science has no doubt played a part in the genesis and growth of big wellness. For virtually the whole of its existence, medicine has disenfranchised women and to varying degrees continues to do so. Even as medicine has modernized with an emphasis on autonomy and resolving bias, it remains at times paternalistic and patriarchal. It comes as no surprise then that women are overrepresented in the wellness industry, both as consumers and providers.

Medical care has not accounted for what women need and want. Women are more often dissatisfied with medical care, feeling that it has failed to recognize their autonomy and unique biological and social needs. Women are more likely to have chronic illness and autoimmune diseases, both of which can be challenging to treat from a doctors point of view but even more challenging to live with.

Even among diseases for which we have made tremendous strides in treatment, female patients are often left behind. Women who experience heart disease are more likely to be subjected to misdiagnosis, inadequate treatment and poor outcomes. In the realm of pain management, women are more likely to be given anti-anxiety medication than painkillers, diminishing their experience with pain. Even in endometriosis, women face a wait of seven years on average until diagnosis. Women also remain underrepresented in research trials, with that absence translating to science that serves men well but lacks understanding of womens bodies and experiences. These differences are not explained wholly by biology but rather structural biases across the medical industry.

If you feel excluded by medicine, why wouldnt you look elsewhere? The wellness industry has filled a gap in health and well-being that the practice and science of medicine have left wide open. The wellness industry purports to be everything that conventional medicine is not egalitarian, hopeful and accessible. Even though it is elitist, privileged and full of falsehoods, it does not matter to those who seek its comfort. Its offering something that my profession, despite advances and improvements, has not been able to deliver consistently.

Last month, the head of Britains National Health Service delivered a stinging assessment of the growth of the wellness industry and the harms that the willful ignorance of science is bringing. Although it is entirely appropriate that health-care professionals fight the rising tide of medical misinformation, if we do not recognize and address our own role in its creation, the fight will be futile. Medicine needs to understand that we have contributed to the Goops of the world. The elevation of expensive and even harmful remedies is in part our own doing.

To truly ensure peoples safety, medicine must of course denounce dangerous, unnecessary and expensive snake oil, but it must also turn our attention inward and provide care that people need and want, communicated with compassion and supporting their autonomy. If we are to ensure that people are protected against medical half-truths and harmful remedies, my profession must move far away from the patriarchal practices that have alienated so many. Medicine has helped create this problem, and we must do better to be its solution.

Nikki Stamp is a heart and lung surgeon in Perth, Australia.

Excerpt from:
Medical industry partly to blame for Paltrow's horrible 'Goop Lab' - Press of Atlantic City

Medical Technology in 2020: the latest on Tech, Biotech and Beauty Tech in the Medical Space – CloutNews

Healthcare is evolving at an exponential pace. Healthcare is an industry that is currently being transformed using the latest technology; so it can meet the challenges it is facing in the 21st century. Technology can help healthcare organizations meet growing demand and efficiently operate to deliver better patient care. We had the chance to chat with Dr. Konstantin Rubinov, an NYC Dental Surgeon specializing in longevity and anti-aging with a focus on regenerative and cosmetic medicine.

Artificial intelligence (AI) is the ability of a computer program or a machine to think and learn with the help of intricate, pre-programmed algorithms. It is also a field of study which tries to make computers smart. As machines become increasingly capable, mental facilities once thought to require solely human intelligence are removed from the definition. AI in healthcare aims to improve patient outcomes by assisting doctors and physicians in using the medical knowledge; which has been analyzed, downloaded and memorized by these systems, and provides superb clinical and medical solutions to modern medical problems that patients face.

AI systems have the potential to provide physicians and researchers with relevant, live, high quality data; from electronic health records (EHRs) to serve immediate needs. The first uses of AI are likely to be in the field of guided surgery and patient triage reports Dr. Rubinov. We are currently seeing increased surgical precision even over 3D printed surgical guides with companies like ClaroNav and XGuide, which are combining various types of 3D imaging technology to deliver real time robotic enabled surgical implant guidance.

A liquid Biopsy has the potential to monitor tumors in a way that is not invasive. The process separates cancer cells from blood samples and can completely transmogrify treatment for cancer through monitoring of the actual cancer cells by non-invasive means. To illustrate the difference, using todays available technologies, repeated biopsies are needed to study; the evolving tumor and present a big issue for the patient. It can be anticipated that in a few years, liquid biopsy will even become a supplementary procedure; to tissue biopsy procedures, says Rubinov. This technology has proven to be much more effective and detects when a disease worsens even before a CT scan can. Considering that oral and pharyngeal cancer is on the rise in the US; this advanced diagnostic technology has immediate daily application in our practice, states Dr. Rubinov

Anti-Aging Medicine, Plastic Surgery and the field of Facial Aesthetics is booming thanks to all the latest available bio-technologies in Cosmetic Medicine. As a veteran cosmetic dentist with 10 years of facial esthetics experience, Dr. Rubinov shares some of the latest Beauty Tech trends in Aesthetic medicine in 2020. Dr. Rubinov believes the biggest advances are in biological material science. The bio-active potential of new injectable Hyaluronic acid fillers and bio-stimulating materials like Sculptra, Radiesse and PRP are showing that we can reverse time when it comes to anti-aging and rejuvenation procedures by stimulating collagen and soft tissues even as we get older, says Rubinov.

One of Dr. Rubinovs favorite bio technologies is the use of blood plasma (PRP) and (PRF) in regenerative aesthetic medicine. While he uses Blood plasma routinely during surgical procedures to help regenerate both hard and soft tissues in the mouth; Using PRP in conjunction with the Derma Pen 4 yields the most beautiful results in facial rejuvenation. With microneedling PRP or The Vampire Facial as the procedure is called, we are able to flood the skin with growth factors and progenitor cells and watch the skin repair itself from years of sun and environmental damage. You become a believer the second you see 20 year old acne scars disappear, says Dr. Rubinov.

In terms of Beauty Tech, European brands are much ahead of their American counterparts. At the 17th Aesthetic and Anti-Aging Medicine World Congress in Monte-Carlo 2019; SkinTech Pharma Group and the cosmetic pharmaceutical giant Allergan devoted huge sections of the show with, live demonstrations of their latest medical bio technologies. Many companies brought tech to the show, with the goal of making skincare and beauty more personal for their customers and providers. 3D Facial analyzers helped with virtual simulations letting clients see exactly what their before and after results will look like. Modface and LOreal both showcased a diagnostic tool to enable customers to virtually try on makeup. And Coty, a pheromone driven fragrance company has an Artificial Intelligence tool which allows one to find the perfect scent match.

Not only are these large brands investing in this futuristic spin on the beauty industry but so are smaller companies such as indie brands and startups like RegenLab PRP. Investments in this way are being made from everywhere because the barrier to entry is much lower; technology is not as expensive as it used to be and the analytics for these purposes are also more readily available, says Rubinov.

Continue reading here:
Medical Technology in 2020: the latest on Tech, Biotech and Beauty Tech in the Medical Space - CloutNews

Black Skin Care Influencers Are Leading the Social Skincare Movement – STYLECASTER

Its a universally acknowledged truth that the topic of skincare is more popular than ever. An industry once hyper-focused on pimples and anti-aging has grown to prioritize wellness and become synonymous (and often conflated) with self-care. Once wildly personal, skincare has gone public, often verging on theaterwhether its a faux-casual selfie of someone eating pasta while masking or a highly produced video of a celebrity washing their face and getting dragged for doing it badly. Theres also an abundance of advice offered by experts and enthusiasts, sometimes the two unable to agree (and people having a hard time deciding whos right).

The world of skincare, in its sheet-masking, serum-applying, carefully-documented glory, is often touted as the great unifier for people of all skin tones, skin types and needs. Theres something for everyone, it claims, the inherent invisibility of products allowing the industry to be slow in its focus on inclusivity and avoid the discussion in a way the makeup sector never could.

Skincare remains another site of privilege where Black people continue the fight to be seen and heard.

Skin of color, in its rich variation of tone and slowness to age, is seen as impenetrable and strong, much like the people who possess it. Its a fallacy with complex ties to a system that has historically ignored Black people or purposefully denied them safe, effective care, and still makes it difficult for us to gain knowledge and achieve goals too.

Before the internet, skincare advice came by way of friends, family and magazines. It was in these spaces that one learned how to shrink a blemish, ways to slow down the skin aging process, and which products were necessary for a dewy glow. It was beauty secrets whispered and passed down, lessons learned by watching and copying.

But Black people rarely got to see their unique challenges addressed outside of trusted circles since these narratives were routinely overlooked by print magazines claiming to service everyone. Things changed with the advent of social media, where previously marginalized communities were able to connect in quasi-public spaces about the shared issues they were facing and address the outlets and brands that had been ignoring them all along.

View this post on Instagram

Melanoma Facts in Skin of Color// : : Malignant melanoma is a skin cancer of melanin producing cells which protect skin from harmful effects of the sun. : People of color are less likely than caucasians to get melanoma but they are much more likely to die from it when they do due to DELAY in DETECTION or ADVANCED DISEASE. : UV radiation remains the major risk factor in melanoma however in POC, it mostly presents in NON-sun exposed places such as the palms, soles, fingernails & toe nails, mouth, genitals & so are often missed. : UV-induced melanomas in POC does still occur given the wide range in shades of complexions, from very fair to very dark. : POC should perform regular monthly head to toe self exams of their skin. Unusual moles, scars, sores, lumps, blemishes or changes in skin texture should be professionally evaluated. : Most importantly, a thorough skin examination including of nails, oral cavity, gums, palms, soles, eyes & genital area should be performed regularly by a dermatologist. : Dark lesions on gums & streaks in nails should be monitored for malignant transformation. : Other risk factors for melanoma in POC include: albinism, burn scars, radiation therapy, trauma, immune suppression and preexisting moles & should be regular evaluated. #melanoma #melanomaawareness #brownskinderm #skininclusive #skinofcolor #slickwoods #skincancer

A post shared by Brown Skin Derm (@brownskinderm) on Nov 22, 2019 at 10:23am PST

Leading the charge are dermatologists, estheticians and enthusiasts, who talk about things like hyperpigmentation, how to identify skin cancer (often caught at a much later stage in Black women) and answer questions that are often still ignored by mainstream media.

If you look at major print magazines before the advent of online beauty blogs, most skincare articles and product advertisements within them did not speak to women of color, says dermatology resident Adeline Kikam, known as the @brownskinderm on social media. Weve just recently started talking about how to care for Black skin and hair on a national level.

These thought leaders with proven influence have shifted the very concept of authority. Whereas outlets and publications were once on the cutting edge, determining the trends and uncovering the next new thing, the roles are now often reversed.

One such influencer is Nayamka Roberts (also known as @LaBeautyologist), a trusted expert in the skincare space, thanks in part to her innovative 60-second rule. But it didnt start out that way. It took a while to find her people, Roberts tells me when we catch up via phone, noting that when she launched her Youtube channel in 2016, no one really cared about skincare or talked about it. Before focusing on skincare, she dabbled in natural hair and food but says the more she spoke about skincare, the more she realized people needed help.

Roberts, who notes she is the only esthetician followed by Barack Obama on Twitter, has nearly 150K followers on the platform, many of whom look to her for guidance about achieving glowy, luminous skin. Her 60-second rulewhich she says is an ideal time frame for allowing the cleansers ingredients to interact with your skin (and for you to interact with yourself), has become so big it often loses attribution. She, like many women of color who have had ideas or disrupted spaces, has seen her concept outsize her, co-opted into mainstream discourse and often leaving her nameless.

And while Roberts acknowledges the ways her work has outgrown her influence, she ultimately wants to educate. I dont really want people to be dependent on brands or even dependent on me, its all about empowering people to know how to take care of themselves, she says.

Dermatologists have also found their way into the movement, using their clinical knowledge to intervene in a space that has often overlooked women of color. Kikam uses her platform as a way to inform and educate, dispelling common myths and sharing products that speak to common concerns for skin of color. I wanted people of color to have a trusted space of evidence-based medicine related to their skin, she says. Since starting her Instagram in 2017, her community has gone global and grown increasingly diverse.

These thought leaders with proven influence have shifted the very concept of authority.

People of color everywhere demand to see themselves reflected in the way skincare is discussed, she explains. Unlike many other platforms her size, Kikam touches on lasers and aesthetics, a space Black people have been historically shut out of or hesitant to discuss due to cultural norms and ideologies that suggest black doesnt crack. Her willingness to shed light on these topics has created a judgment-free zone, where people are able to open up about conditions theyre often too embarrassed or nervous to discuss.

View this post on Instagram

//Lasers work by using wavelengths of light specific to & well absorbed by target structures in skin termed chromophores (melanin, collagen,hemoglobin, water, DNA or a foreign substance like tattoo ink) to yield a therapeutic outcome w/ minimal damage to surrounding skin. : skin of color' has unique characteristics that pose challenges to laser therapy; increased epidermal melanin, easily altered melanocytes(associated w/ greater post procedure pigment complications) & reactive fibroblast (promotes scarring). : #melanin has a wide absorption spectrum ranging from 2501200 nm, thus all visiblelight & near-infrared dermatologic lasers currently used in dermatology can target melanin. : At issue in SOC is epidermal melanin absorption of laser energy with resultant heat injury leading to hyperpigmentation & scar formation. : The safest wavelengths forSOC are those in the near infrared range; the 800810nm diode & the 1064nm (Nd:YAG) lasers most especially. Their longer wavelengths bypass the topmost epidermal layer of #skin prone to damage. : Longer wave-length lasers allow targeting of deeper structures in the dermis of skin such as hair while sparing the epidermis. : Contrary to popular misconception, lasers can be used in darker skin types albeit more cautiously, selectively & appropriately given greater risks of #hyperpigmentation & #scarring. Top uses of Lasers in SOC: #hairremoval Photo-rejuvenation: fine lines wrinkling, mottled pigmentation, Benign growths such as #dermatosispapulosanigra Skin tightening Pseudo-folliculitis #tattoo removal #acnescars Stretch Marks

A post shared by Brown Skin Derm (@brownskinderm) on Dec 5, 2019 at 3:58pm PST

Shes also one of few dermatologists to discuss the long term effects of skin bleaching and conditions like hidradenitis suppurativa, an autoinflammatory condition that disproportionately affects Black women and results in painful lumps and discharge in areas like the groin and armpit. By being able to articulate her symptoms better to her primary care doctor and bringing up the possibility that she may have HS based on what she had seen on my page, she was able to convince her primary care doctor to refer her to a dermatologist, she shared.

Kikam says this happens often and while shes happy to be part of pushing the conversation, shes cautious of her role in a highly commercialized space. I think the information on skincare needs to be accessible and affordable across all classes and not come off as elitist and exploitative.

True inclusivity is specific and meets people where theyre at rather than demanding it happen the other way around.

Its this work that pushes the conversation forward, but the skincare industry still has a long way to go. True inclusivity is specific and meets people where theyre at rather than demanding it happen the other way around. Brands and publications could take a page from Kikam and Robertss books, and use their platforms to center and consider these skincare concerns rather than add them in later or pretend they dont exist.

We need education in both the clinical and social spaces, where people of color are foregrounded and given the same attention as their white counterparts. Until then, skincare remains another site of privilege where Black people continue the fight to be seen and heard.

Read the rest here:
Black Skin Care Influencers Are Leading the Social Skincare Movement - STYLECASTER

How have our grey seals adapted to eat venomous weever fish? – The Irish Times

Ireland can boast one of the least toxic terrains on the planet, at least for people. With the exception of a few deadly mushrooms, which are avoidable, the most poisonous wildlife drifts in from outside notably a few stinging jellyfish.

Few if any of our fellow mammals in Ireland have needed to evolve ways of eating other, venomous, creatures. In the rest of the world at least 3O mammals are known to have developed biochemical defences that negate a poison or numb response to pain.

That could be said, I suppose, about Irelands badgers and pine martens, attacking bees and wasps nests for grubs. But our hedgehogs, unlike some of those in continental Europe, do not include scorpions or vipers in their prey.

All this makes it more intriguing that some Irish grey seals may specialise in eating the venomous weever fish, Echiichthys vipera, whose piercing of any human foot can prove extremely painful.

Wintering at the moment in near-hibernation in deeper, warmer water at perhaps 150 metres, the hand-size lesser weever returns to the shallows in early summer, burrowing into the sand and resting there with just its eyes and the tip of its black dorsal fin exposed. Its ambition is the ambush of little fish such as blennies and gobies with a dart of its upward-pointing mouth.

It is also equipped to punish anything that tries to eat it, or otherwise presses on its venomous dorsal spines. It can stay buried as the tide recedes and wait in the sand until the water comes back.

Fear of the weever would occasionally haunt my own childhood paddling on the intertidal sands of Sussex. The memory was revived a year or two ago when Mayo surfers at nearby Carrowniskey began writing agitated blogs about the apparent concentration of weevers on that strand.

On the rare occasions when it is plentiful, one expert wrote, rows of erect black triangles decorate the sand floor of the seabed.

Something like that may have supplied the remarkable appetite of some seals for weevers reported in Biology and Environment, the journal of the Royal Irish Academy. The discovery is a spin-off from a study by four researchers at UCC, led by Dr Martha Gosch, examining the diet of grey seals for potential impact on commercial fisheries.

This entailed gathering some 150 seal scat (droppings, faeces) from sand banks at Raven Point in Wexford Harbour used as a haul-out by up to 300 animals. Collected between cleansing tides and across two years, the scats were unlikely to repeat offerings from the same individuals.

Weever remains, including the bony otoliths of the inner ear (a standard identification of fish), were found in 4 per cent of the droppings, including one scat with remains of 76 of them, plus one sign of flatfish. The relatively high abundance of weever in a limited number of scats, the study concluded, was some evidence for specialisation.

It also suggested that the seals had developed a way of eating the fish without suffering from the venom. The skin inside a seals mouth and oesophagus is not especially thick compared with that of the leatherback turtle, which regularly eats jellyfish with toxic stings. Grey seals tend to eat fish whole, suggesting that they may have learned to gulp weevers head first, helping to push the poison spine flat.

Seals themselves figure among specialised choices of prey. Wildlife films have shown spectacular and chilling sequences of killer whales (orcas) killing seals, surging onto beaches to drag them into the sea on the southern coast of Argentina or ganging up to make waves that wash Arctic seals off ice floes.

Given the abundance of seals off Ireland and Scotland, this has me wondering why the orcas two separate groups with seven or eight in each have seemed to leave them alone.

Some genetic research on orcas, including those of the north Atlantic, suggests that their small social groups have created cultures of hunting that are genetically inherited. Some, more nomadic, groups are seal eaters while others hunt fish and seabirds off particular coasts. The orcas that commute between west Scotland and Ireland are well-known as fish eaters, though others have been filmed eating harbour porpoises off Scotland.

At Shetland last September, orcas were videoed flipping a harbour seal pup into the air, like the playful assassins of Argentina. And new research from the University of Aberdeen potentially links the orcas to a dramatic decline in numbers of Scotlands harbour seals, with numbers in Orkney and Shetland dropping by 40 per cent in five years.

Unlike the grey seals, which pup in late autumn, the smaller harbour seals pup in June and July, the months when most orca sightings are reported to the Irish Whale and Dolphin Group. The last harbour seal surveys, almost two decades ago, found more than 4,000 of them around Irelandcoasts. It may soon seem appropriate to count them again.

See the rest here:
How have our grey seals adapted to eat venomous weever fish? - The Irish Times

The Next President of the American Heart Association Is a Columbia Neurologist – Columbia University Irving Medical Center

Columbia neurologist Mitchell Elkindbecomes the president of the American Heart Association in July 2020, only the second time a neurologist has served as president of the organization. Photo: Columbia University Irving Medical Center.

The good news about cardiovascular disease in the United States is that its becoming less deadly: From 2006 to 2016, the death rate from all cardiovascular diseases decreased by 18.6%and by 31.8% for heart disease related to atherosclerosis.

The bad news is that cardiovascular disease remains the leading cause of death, responsible for 840,768 deaths in 2016.

For nearly 100 years, the American Heart Association has been dedicated to fighting heart disease and stroke.

And starting in July, the organization will be presided over by a neurologist, Mitchell Elkind, MD, professor of neurology at Columbia University Vagelos College of Physicians and Surgeons and an attendingatNewYork-Presbyterian Hospital.

We recently spoke with Elkind about heart disease and its relationship to brain health. The following transcript has been edited for brevity and clarity.

The AHA is not a professional organization for physicians, its really a public health organization. It's geared towardpreventing cardiovascular disease, especially heart attacks and strokes. And it does this through a combination of public education campaigns, raising physician awareness of best practices, and research.

So its not just an organization of cardiologists; there areneurologists, public health specialists, epidemiologists, nutritionists, physical therapists, occupational therapists, nurses, all kinds of people interested in preventing cardiovascular disease.

Also, over the last 20 to 30 years, stroke has become a really important focus of the AHA, and, more recently, the association has gotten interested in brain health in general.

I think some of the most exciting research now is at the intersection among heart disease, stroke, and brain health.

Were learning that sleep, for example, is important for heart health, an area that Columbia researchers are involved in.

For women, poor sleep could contribute to unhealthy food choices, increasing the risk of obesity and heart disease, a new study from researchers at Columbia University Irving Medical Center reports. Read more here.

Were also finding that depression and anxiety often take a toll on peoples physical health; people stop exercising, or they smoke to help themselves cope. By the same token, when people have heart disease or a stroke, it's not uncommon that they develop depression or anxiety afterward.

There's a lot of interest now in atrial fibrillation, when the small chambers of the heart don't beat normally and people feel their heart racing. The biggest complication of a-fib though, is a stroke, because blood clots can form in the heart and travel to the brain.

We're learning that atrial fibrillation is much more common than we thought. The condition isnt always persistent; it can come and go, and some people may have only a few minutes of atrial fibrillation every few weeks. But they still carry a risk of stroke.

These heart problems underlie many of the unexplained strokes that neurologists see. And if we can detect people with these problems, its possible that treating them with blood thinners, like atrial fibrillation patients, will reduce the risk to the brain.

We actually got pretty close; since 2010 weve reduced deaths from cardiovascular disease overall by about 10%and from heart disease alone by 28%.

So in some specific areas we have seen tremendous declines in cardiovascular disease over the last couple of decades. But we're actually starting to see that level off now, and for stroke were actually seeing an increase over the past few years.

There area few things that may be reversing the trend. Substance abuse may be a factor, along with increasing obesity and sedentary lifestyles. And were worried that the popularity of vaping among young people could potentially lead to an increase in smoking.

Overall, the picture has been positive, but we don't want to lose the progress that we've made.

One step is creating a simple message for the public. The AHA createdLife's Simple 7, which are seven things people should do to maintain health: exercise at least five days a week, watch your diet, maintain a healthy weight, do not smoke, reduce blood sugar, control cholesterol, and manage blood pressure.

How do we get people to change behavior? That's been very challenging, but through what we call implementation science, people are coming up with new ideas.

It doesn't all have to happen at the doctor's office, either. Were using non-traditional approaches to reach people, whether it's through churches, which has been very effective in the African American community, or in hair salons and barbershops, where you can get your blood pressure checked while waiting to get your hair cut.

Read more:
The Next President of the American Heart Association Is a Columbia Neurologist - Columbia University Irving Medical Center

Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR | TCRM – Dove Medical Press

Marco Luigetti,1,2 Angela Romano,2 Andrea Di Paolantonio,2 Giulia Bisogni,3 Mario Sabatelli2,3

1Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 2Universit Cattolica del Sacro Cuore, Rome, Italy; 3Centro Clinico NEMO Adulti, Rome, Italy

Correspondence: Marco LuigettiNeurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A Gemelli 8, Rome 00168, ItalyTel +39-06-3015 4435Fax +39-06-3550 1909Email mluigetti@gmail.com

Abstract: Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy) is a rare disease due to mutations in the gene encoding transthyretin (TTR) and characterized by multisystem extracellular deposition of amyloid, leading to dysfunction of different organs and tissues. hATTR amyloidosis represents a diagnostic challenge for neurologists considering the great variability in clinical presentation and multiorgan involvement. Generally, patients present with polyneuropathy, but clinicians should consider the frequent cardiac, ocular and renal impairment. Especially a hypertrophic cardiomyopathy, even if usually latent, is identifiable in at least 50% of the patients. Therapeutically, current available options act at different stages of TTR production, including synthesis inhibition (liver transplantation and/or gene-silencing drugs) or tetramer TTR stabilization (TTR stabilizers), increasing survival at different disease stages.

Keywords: amyloid, polyneuropathy, clinical care, therapy, transthyretin

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Read more here:
Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR | TCRM - Dove Medical Press

Global Neurology Software Market 2020-2025: Increasing demand with Industry Professionals like Greenway Health, Kareo, Practice Fusion, Advanced Data…

The Global Neurology Software Market report draws precise insights by examining the latest and prospective industry trends and helping readers recognize the products and services that are boosting revenue growth and profitability. The study performs a detailed analysis of all the significant factors, including drivers, constraints, threats, challenges, prospects, and industry-specific trends, impacting the market on a global and regional scale. Additionally, the report cites worldwide market scenario along with competitive landscape of leading participants.

Get Sample Copy of the Report @ https://www.reportsweb.com/inquiry&RW00013259021/sample

The Neurology Software market analysis is intended to provide all participants and vendors with pertinent specifics about growth aspects, roadblocks, threats, and lucrative business opportunities that the market is anticipated to reveal in the coming years. This intelligence study also encompasses the revenue share, market size, market potential, and rate of consumption to draw insights pertaining to the rivalry to gain control of a large portion of the market share.

Leading Players in the Neurology Software Market: Epic, Bizmatics, Athenahealth, healthfusion, Allscripts, Nextgen, Brainlab, Greenway Health, Kareo, Practice Fusion, Advanced Data Systems, NueMD and more

Competitive landscape

The Neurology Software Industry is extremely competitive and consolidated because of the existence of several established companies that are adopting different marketing strategies to increase their market share. The vendors engaged in the sector are outlined based on their geographic reach, financial performance, strategic moves, and product portfolio. The vendors are gradually widening their strategic moves, along with customer interaction.

Neurology Software Market Segmented by Region/Country: US, Europe, China, Japan, Middle East & Africa, India, Central & South America

For discount click here: https://www.reportsweb.com/inquiry&RW00013259021/discount

Type of Neurology Software Market:

Advanced Neurology EMR Software

Other

Application of Neurology Software Market:

Hospitals

College & Research Institutes

Other

Points Covered in the Report:

Access full Report Description, TOC, Table of Figure, Chart, etc. @ https://www.reportsweb.com/buy&RW00013259021/buy/3660

Thanks for reading this article; you can also customize this report to get select chapters or region-wise coverage with regions such as Asia, North America, and Europe.

Table of Content

Chapter 1: Industry Overview

Chapter 2: Neurology Software Market International and China Market Analysis

Chapter 3: Environment Analysis of Market.

Chapter 4: Analysis of Revenue by Classifications

Chapter 5: Analysis of Revenue by Regions and Applications

Chapter 6: Analysis of Neurology Software Market Revenue Market Status.

Chapter 7: Analysis of Industry Key Manufacturers

Chapter 8: Conclusion of the Neurology Software Market Industry Research Report.

Continued to TOC

About ReportsWeb:

ReportsWeb is a one stop shop of market research reports and solutions to various companies across the world. We help our clients in their decision support system by assisting them choose most relevant and cost effective research reports and solutions from various publishers. We provide best in class customer service and our customer support team is always available to help you on your research queries.

Contact Us:

Name: Sameer JoshiEmail: sales@reportsweb.comPhone: +1-646-491-9876

See the article here:
Global Neurology Software Market 2020-2025: Increasing demand with Industry Professionals like Greenway Health, Kareo, Practice Fusion, Advanced Data...

Flea and tick medication companies respond to 5 On Your Side – WRAL.com

Elanco Animal Health (Credelio)

"Weve worked diligently to communicate the class change to veterinarians and also feature specific language on seizures in our Credelio advertisements. Also, FDA did not determine the final language re: seizure risk until after Credelio was approved. So, Elanco included the following language in the Credelio label with approval from the FDA: 'Use with caution in dogs with a history of seizures' at time of product approval."

"Nothing is more important to Merck Animal Health than the safety and efficacy of our products and the well-being of animals. We continue to encourage all pet owners to speak to their veterinarian before making any decisions about flea and tick control products. Parasites like fleas and ticks are not only a nuisance for pets and their owners, but if left untreated they can transmit serious diseases to pets.

It is important to note that the FDA updated the labeling for the entire class of isoxazoline drugs in September of 2018.

Pet-owner product materials, including advertising, displays and brochures have been updated with the new safety information.

Merck Animal Health is confident in the safety and efficacy of our products such as Bravecto and follow all legal and regulatory requirements. The safety and efficacy of Bravecto has been established through comprehensive research in more than 170 clinical research studies. In addition, more than 125 million doses of Bravecto have been distributed in 85 countries. The overall worldwide reporting rate for adverse events for our products containing isoxazoline remains classified as rare."

"In September 2018, the U.S. Food and Drug Administrations (FDA) Center for Veterinary Medicine (CVM) released a public communication to pet owners and veterinarians regarding the use of flea-and-tick-control products within the isoxazoline class of drugs. In this announcement, the FDA reported receiving reports of neurological signs in some dogs and cats following the use of products within the class. CVM issues these communications to veterinarians and pet owners to aid in making decisions about animal health products.

NexGard is an oral, beef-flavored soft chew that is administered monthly to dogs. It contains the active substance afoxolaner, a compound in the isoxazoline class, for the treatment and prevention of flea infestations and the treatment and control of ticks in dogs for one month. NexGard is approved by regulatory authorities for use in more than 100 countries, with more than 330 million doses sold worldwide. While the FDA notes that reports involving neurological signs have been reported for all isoxazoline products, they remain very rarely reported with NexGard (very rare defined as The most commonly reported adverse events in the US are vomiting, pruritus, lethargy, diarrhea, and anorexia. The NexGard label was updated with the information that the FDA described in their announcement.

The efficacy and safety of our products are paramount, and we believe that it is important for veterinarians and pet owners to be aware of any potential risks associated with products used in pets. As with any veterinary product, we recommend that pet owners discuss with their veterinarian before using a product."

"Zoetis colleagues, many of us pet owners, care about the well-being of pets, and we are committed to providing safe and effective products to veterinarians, pet owners and the animals in their care. We all sympathize with the frustration and concerns of pet owners when their pets are sick.

Our product Simparica (sarolaner) Chewables is one of four tick and flea medications for dogs in the isoxazoline class currently on the market. The labeling for Simparica is approved by the FDA. The product label and all of our promotional materials have always included information about neurologic signs such as tremors, unsteadiness, and/or seizures that have been associated with use of medicines in the isoxazoline class in some dogs.

Our product labeling for Simparica was approved by the FDA and updated in June 2019 to reflect their comments on neurologic events. Here is the website with prescribing and safety information for Simparica. You can click through from here for more detailed information that is shared in the packaging as well. https://www.zoetisus.com/products/dogs/simparica/prescribing-information.aspx

We are confident that Simparica, which has been sold in the U.S. for 4 years, remains an effective and safe tick and flea option for dogs. The overall global reporting rate for any clinical sign reported for Simparica (including vomiting, lethargy, diarrhea or any neurologic sign), is classified as very rare as defined by international regulatory authorities as less than 1 report per 10,000 doses administered (This rate was calculated based on all reports regardless of any causal relationship to the product). Simparicas adverse event profile continues to be predictable and consistent with pre-approval studies and looks similar to other isoxazoline products on the market.

We focus on ensuring veterinarians have the proper education, prescribing and safety information to share with pet owners, so that they can best advise each pet owner which products are the best choice for their individual pet and best suited to each pets medical needs. We also encourage pet owners to have regular conversations with veterinarians about their pets health.

Unfortunately, all medicines come with some potential risks and side effects and that is why their use should always be taken in consultation with a veterinarian. For the vast majority of pets, tick and flea medicines are safe, effective and help greatly reduce health risks that can come from parasites, such as Lyme disease, anemia and other infectious diseases. These are serious health concerns for all dogs and regular use of tick and flea medicines is recommended by veterinarians throughout the United States.

Revolution Plus for cats is also an isoxazoline product (sarolaner) and was approved in the U.S. in 2018 and launched there in 2019. Simparica was approved in launched in the U.S. in 2016."

Read the rest here:
Flea and tick medication companies respond to 5 On Your Side - WRAL.com

Miracle On Ice Still Inspires On 40th Anniversary – WAMC

Today is the 40thanniversary of one of the biggest upsets in sports history. And it all happened in upstate New York.

By now, sports fans know Al Michaels call by heart, but the Olympic mens hockey medal round game on February 22, 1980 actually wasnt seen by the vast majority of Americans in real time unless you had a ticket.

The game between the U.S. and the Soviet Union was shown on tape delay on ABC. And in the pre-cell phone age, it was possible to keep the stunning result secret.

But the scoreboard in whats now Herb Brooks Arena, named for the Americans demanding coach, said it all: the U.S. scored twice in the first period and twice more in the third to win the game 4-3 and attain sports immortality.

This was an upset, this was a gigantic, gigantic upset, and so thats why the word miraculous came into my brain and I said what I said. But that had everything to do with what an upset, what an incredible moment this is, and not something that I ever thought would live in posterity, Michaels said.

Team captain Mike Eruzione scored the go-ahead goal.

For some it was a hockey victory and for some it was a political meaning, Eruzione said. Something as a country for a short in the arm, and I think realizing what we did 40 years ago, I guess we brought a lot of pride back to a country that was looking for something, and it happened to be us.

The U.S. went on to beat Finland 4-2 two days later to win the gold medal after Brooks told the Americans they would take it to their grave if they didnt win the whole thing.

Today, the Miracle on Ice is remembered as an important moment in the Cold War, its meaning mythologized to the extent that when the arena finally replaced its scoreboard in 2017, pieces of the old one from that iconic Friday evening were already being claimed.

Left wing Buzz Schneider came back to the arena for the decommissioning.

Its part of history and its going to be gone but I can understand why theyre doing it. But itll be missed by me for sure.But I want to touch that 4 to 3 before I see it disappear, he said.

Made into countless documentaries, two feature films and ranked as the top Sports Illustrated cover of all-time, the games details have become familiar even for people too young to remember it: how the college athletes banded together under Brooks hard-driving approach, how they rebounded from a 10-3 exhibition loss to the Russians just before the Games, and how they never gave up against them despite trailing three times.

The Russian team was heavily favored after winning four straight Olympic gold medals. Michaels said ABC was just hoping to have the Americans within two goals in the third period to keep viewers. An outright victory seemed out of the question.

With exactly 10 minutes to go, whoa, holy mackerel, is this possible? And then at that point the crowd is just going out of its mind.

For Eruzione, who has been talking about that week in Lake Placid for four decades, the lesson is simple:

You believe in miracles, you believe in working hard, you believe in sacrifice and anything can happen.

As Olympic anniversary events continue in Lake Placid, a U.S. hockey team reunion is scheduled for today in Las Vegas.

Excerpt from:
Miracle On Ice Still Inspires On 40th Anniversary - WAMC

Rozner: Andre Dawson says ‘cheating is cheating,’ and Astros should vacate title – Chicago Daily Herald

Andre Dawson has had 18 knee surgeries.

That includes three knee replacements. Yeah, one of them had to be done twice because the first one didn't take.

Thanks very much.

It could be argued that the 65-year-old gave to the game of baseball everything his body would allow, so when he speaks you can be certain it's with love and concern for the sport.

And on the issue of the Houston Astros, he isn't at all vague.

"They should forfeit the title," Dawson said. "It's like I felt all along about steroids.

"Those guys reaped the rewards and they should suffer the ramifications. They got elite status and made a lot of money and achieved all the accolades.

"Cheating is cheating. It's not fair and you should pay a price for that. They should take away the title."

Dawson was taken aback when informed that commissioner Rob Manfred thought the World Series trophy was nothing more than an irrelevant "piece of metal" and not worth retrieving from the Astros.

"It's much more than a piece of metal to all of us who played," Dawson said. "It's the prestige of winning and being a part of history. It's the glory of getting through an entire season and being the last team standing.

"It's something that you live with for the rest of your life when you win, and it's something that you live with for the rest of your life if you don't get that chance."

There are some very familiar names on that unpleasant list, the leaders of a club no one wanted to be a part of, the men who appeared in the most MLB games in history without ever playing in a World Series game.

Topping the list is Rafael Palmeiro, second is Hall of Famer Ken Griffey Jr. and third is future Hall of Famer Ichiro Suzuki.

Not surprisingly, there are many Cubs in the Top 30.

Having retired as the leader, Dawson is No. 4 all-time with 2,627 games and Ernie Banks -- who also retired as the leader -- is No. 5.

Billy Williams is No. 7, Ron Santo is at No. 21 and Ryne Sandberg is No. 28. They have all been elected to the Hall of Fame, but not one of them got what they wanted most, to play in the Fall Classic.

White Sox great Luke Appling is No. 10 with 2,422 games played -- retiring in 1950 atop the list -- and fellow Hall of Famer Frank Thomas is 17th. At least Thomas was with the club and got a ring when the Sox won the 2005 World Series, but he was not on the roster due to injury.

Ask any of those mentioned above and they'll tell you they feel incomplete, even having achieved immortality and a place in baseball's most hallowed museum.

"I got close a couple times," Dawson said of the '81 Expos and '89 Cubs. "Those are things you think about every year when you watch teams celebrate.

"That's the dream when you have a club that you know can go far, but a lot of things have to go right and you need some luck.

"You've got to have the personnel. I don't care how good you are individually. Ernie can attest to that. If you don't have the personnel, it's not happening.

"There's no use beating yourself up. It's just hard when you play against your peers and you see them get there. For some of us, you just have to accept that it wasn't meant to be."

That drives home even deeper the foolishness of Manfred diminishing the trophy.

To hear the pain in Dawson's voice and to have seen up close the pain he endured, you can't help but feel for a guy who wanted it that much.

"If I had to do it all over again, I would do it again," Dawson says with no hesitation. "My knee problems helped build my work ethic, and my attitude was to get that uniform back every year, as opposed to them taking it away from me.

"After that, it was all a bonus."

It doesn't minimize his distaste for those who used PEDs or swiped a championship.

"People do stuff for selfish reasons, for personal gain," Dawson said. "But now they're gonna have to deal with the fallout, and that fallout can come in a lot of ways.

"It's going to be pretty uncomfortable for them this season and probably for a long time. Like with steroids, probably some of them will never get away from it.

"They knew what they were doing and they knew it was wrong, or else they wouldn't have tried to hide it."

True enough.

Follow this link:
Rozner: Andre Dawson says 'cheating is cheating,' and Astros should vacate title - Chicago Daily Herald

The blindfold of justice | Church Page – Murray Ledger and Times

We talked earlier about the sword of justice and the scales. The demand that a penalty be paid for sin made the sacrifice of Christ necessary for God to forgive us and remain a just God. The reason the judgments of God are always true and righteous is that He has all the facts and He possesses unparalleled integrity. Lady Justice is depicted, not only with a sword and scales, but she is also wearing a blindfold, the symbol of impartiality.

Righteous judgment requires the careful consideration of relevant evidence and, frankly, there are factors that are totally irrelevant to the determination of truth. A persons guilt or innocence will be revealed by indicators like forensic evidence, surveillance video, eyewitness accounts and alibis, not the defendants race, nationality, gender or social status. The blindfold symbolizes blindness toward factors that dont matter.

The Scriptures clearly show the perfect impartiality of God. Not only do they indicate the things that are irrelevant to His willingness to fellowship a person, they emphasize the legitimate determining factors. Notice the definition of Gods impartiality.

God doesnt care about race or nationality. Explaining why he had gone to the home of a Gentile family to teach them the gospel, Peter said, I most certainly understand now that God is not one to show partiality (Acts 10:34). Paul wrote that God promises glory and honor and peace to everyone who does good, to the Jew first and also to the Greek. For there is no partiality with God (Romans 2:10).

God doesnt care about social status. Slavery was a conspicuous component of the Roman economy in the first century, but God held both slave and master in equal esteem. After giving instructions to slaves about respecting their masters, Paul told masters, Do the same things to them, and give up threatening, knowing that both their Master and yours is in heaven, and there is no partiality with Him (Ephesians 6:9).

God doesnt care about your bank account. James devoted a considerable amount of time condemning favoritism toward the wealthy in James 2. Verse 5 says, Did not God choose the poor of this world to be rich in faith and heirs of the kingdom which He promised to those who love Him?

So what does God care about? Paul defined the God of righteous judgment who will render to each person according to his deeds: to those who by perseverance in doing good seek for glory and honor and immortality, eternal life (Romans 2:6-7).

There are two important lessons here: 1) God focuses on each persons character and we should too, and 2) God rewards those who diligently seek Him (Hebrews 11:6); if you are not diligently seeking God it is high time you started.

Editors Note: Opinions expressed do not necessarily reflect the editorial opinion of the Murray Ledger & Times.

Read the original post:
The blindfold of justice | Church Page - Murray Ledger and Times

This exhibition reveals Warhols dark preoccupation with death – Dazed

The popular caricature ofAndy Warhol as the king of pop art brings with it all the connotations of lightness and frivolity that accompany such an accolade. His most famous artworks are radiant with the brightly-coloured vibrancy and glamour of advertisements. If you want to know all about Andy Warhol, just look at the surface of my paintings, and there I am. Theres nothing more, the artist famously claimed. But a new exhibition exposes a darker side to Warhol thats been hiding in plain sight this whole time.

Warhols fascination with immortality is visible throughout his work, in his preoccupation with fame and popular culture. But a new exhibition, Andy Warhol: Heaven and Hell Are Just One Breath Away,focuses on his equally powerful obsession with mortality. His published diary reveals a preoccupation and neurosis about his own health, and his near-death experiences are well publicised (he battled with tuberculosis as a child and he was briefly declared clinically dead on the operating table after being shot by Valerie Solanas), but his spirituality is less known. Warhol was a practising Catholic and, once you learnthis, you cant unsee the influence of religion everywhere in his art and practice: his deification of figures from popular culture into secular saints, his interest in iconography, the many ways he memorialised the relics of everyday life, his general capacity to worship.

Today marks the33rd anniversary of his death on 22 February 1987, Heaven and Hell Are Just One Breath Away brings together Warhols work that is most explicitly inspired by religious iconography and which confronts mortality most directly, including Skull (1976) and The Last Supper (1986). Below, we talk to Bianca Chu, the Deputy Director, Curator of S|2 Gallery about Warhols darker preoccupations and his obsession with his own mortality.

How does this exhibition reveal a different aspect of Warhol?

Bianca Chu: Warhol needs no introduction, his creative output and recognition are cemented in history. But, often with iconic figures like this, the passing of time can allow for new interpretations. In this exhibition, we aim to spotlight a body of Warhols work which focuses on his deeply private relationship with his faith, and the unavoidable condition of mortality. These concerns are often overlooked in mainstream exhibitions of Warhol but, as we approach the 33rdanniversary of his death, there has been a flurry of moments where these last years have become more at the forefront, such as the recentRevelationsexhibition at the Warhol Museum in Pittsburgh. As our exhibition opens just before the major retrospective at the Tate Modern, which will undoubtedly be a spectacular survey of his achievements, we wanted to drill more deeply into the last days of his life a time when the artist may have been more vulnerable and contemplative.

His interest in immortality is evident throughout his work. How does his obsession with mortality reveal itself?

Bianca Chu: I think that Warhol plays with the tension between the eternal and the fleeting. Portraying celebrities, scenes of death and disaster, everyday objects like soup cans, on canvases, on the one hand, reveals an attempt to immortalise people, events and things, yet it also seems to recognise their fleeting existence. Warhols works perch on the knife-edge ofdouble entendre: hailing a person or moment in history as something worth memorialising while, at the same time, declaring those people or events as already in the past. For Warhol, nothing appears sacred or untouchable, life and death alike.

Fewpeople are aware that Warhol was a practising Catholic. Do you think his religion inflamed his obsession with death?

BiancaChu: We know that Warhol grew up in a religious household. His childhood home was filled with icons of holy figures and even a photographic reproduction of Da Vincis The Last Supperhung in the kitchen, but it would be an oversimplification to state that religion was the reason for his obsession with death. The failed assassination attempt in 1968 would have likely had a deep impact on his perception of death. I also think that Warhol would have seen himself within the greater canon of master artists. Death is a recurrent subject throughout art history, especially in Catholic iconography.It is a universal concern for artists from the Italian renaissance to now; it is the one experience that no one can escape.

For Warhol, nothing appears sacred or untouchable, life and death alikeBianca Chu

Freud discussed what he called the death drive as oppositional to the sex drive. Warhol seems to have had an ambiguous or problematic relationship with sex. Does his fascination with death shed any light on his attitude towards sex?

BiancaChu: Warhol never openly admitted anything about his sexuality, not even in his personal diaries. He seemingly revelled in the ambiguity and conjecture surrounding it.

How do you feel that his work was affected by his proximity to the Aids epidemic that killed so many of his friends in the New York art world?

BiancaChu: Alexander Iolas, the Greek gallerist that commissioned Warhols first New York exhibition, was in the late stages of Aids-related illness when he commissioned Warhol to make TheLast Supperseries (1986). This went on the be the last exhibition for them both, as they both died within two months of the opening. It is possible that this final body of work by Warhol was a nod to those people who were inextricably bound to his life and work and impacted by the epidemic.

Many scientists claim were close to achieving immortality. Do you think if Warhol were still alive now hed be signing himself up for cryogenic experiments with eternal life and having his consciousness downloaded onto a hard drive etc?

BiancaChu: I can imagine Warhol creating his own fashionable factory of cryogenics for all the celebrities and icons of the day. Of course, his studio would have already beenthespot for uploading your consciousness to the Warhol cloud.

Andy Warhol: Heaven and Hell Are Just One Breath Away is showing atSotheby's S|2 Gallery until 28 February 2020

See the original post here:
This exhibition reveals Warhols dark preoccupation with death - Dazed