Gene ID’d as potential therapeutic target for dementia in Parkinson’s – Washington University School of Medicine in St. Louis

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Targeting gene linked to Alzheimers may reduce dementia risk in Parkinsons

Clumps of the Parkinsons protein alpha-synuclein (red) are visible inside neurons (green) in the brain of a mouse. Researchers at Washington University School of Medicine in St. Louis have discovered that the genetic variant APOE4 long linked to dementia spurs the spread of harmful clumps of Parkinsons proteins through the brain. The findings suggest that therapies that target APOE might reduce the risk of dementia for people with Parkinsons disease.

Dementia is one of the most debilitating consequences of Parkinsons disease, a progressive neurological condition characterized by tremors, stiffness, slow movement and impaired balance. Eighty percent of people with Parkinsons develop dementia within 20 years of the diagnosis, and patients who carry a particular variant of the gene APOEare at especially high risk.

In new research, scientists at Washington University School of Medicine in St. Louis have found a clue to the link between Parkinsons, APOEand dementia. They discovered that harmful Parkinsons proteins spread more rapidly through the brains of mice that have the high-risk variant of APOE, and that memory and thinking skills deteriorate faster in people with Parkinsons who carry the variant. The findings, published Feb. 5 in Science Translational Medicine, could lead to therapies targeting APOEto slow or prevent cognitive decline in people with Parkinsons.

Dementia takes a huge toll on people with Parkinsons and their caregivers, said Albert (Gus) Davis, MD, PhD, an assistant professor of neurology and the studys lead author. The development of dementia is often what determines whether someone with Parkinsons is able to remain in their home or has to go into a nursing home.

An estimated 930,000 people in the U.S. live with Parkinsons. The disease is thought to be caused by toxic clumps of a protein called alpha-synuclein that build up in a part of the brain devoted to movement. The clumps damage and can kill brain cells.

Cognitive problems tend to arise many years after the motor symptoms. The protein clusters implicated in movement problems also are linked with dementia, but how this happens is not clear. Davis and his colleagues including senior author David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of theDepartment of Neurology saw a clue in the risky nature of APOE.

A variant of APOE known as APOE4 raises the risk of Alzheimers disease threefold to fivefold. Like Parkinsons, Alzheimers is a neurodegenerative condition caused by the spread of toxic protein clusters throughout the brain, although some of the proteins involved are different. APOE4 increases the chance of Alzheimers dementia partly because it spurs Alzheimers proteins to collect into clumps that injure the brain. The researchers suspected that APOE4 similarly triggers the growth of toxic clusters of Parkinsons proteins.

Studying mice with a form of alpha-synuclein prone to clumping, Davis, Holtzman and colleagues genetically modified the mice to carry human variants of APOE APOE2, APOE3 or APOE4 or no APOE at all.

The researchers found that APOE4 mice had more alpha-synuclein clusters than APOE3 orAPOE2mice. Further experiments showed that the clumps spread more widely in APOE4 mice as well. Together, the findings showed that APOE4 was directly involved in exacerbating signs of disease in the mices brains.

What really stood out is how much less affected the APOE2 mice were than the others, Davis said. It actually may have a protective effect, and we are investigating this now. If we do find that APOE2 is protective, we might be able to use that information to design therapies to reduce the risk of dementia.

To study the effect of APOEvariants on dementia in people with Parkinsons, the researchers analyzed publicly available data from three separate sets of people with Parkinsons. Two of the cohorts one from the Parkinsons Progression Markers Initiative, with 251 patients, and the other from the Washington University Movement Disorders Center, with 170 patients had been followed for several years. In both cohorts, cognitive skills declined faster in people with APOE4 than in those with APOE3. People with two copies of APOE2 are very rare, but none of the three patients in the group with two copies of APOE2showed any cognitive decline over the period of the study.

The third cohort, fromthe NeuroGenetics Research Consortium, was made up of 1,030 people with Parkinsons whose cognitive skills had been evaluated just once. The researchers found that people with APOE4 in the cohorthad developed cognitive problems at a younger age and had more severe cognitive deficits at the time they were evaluated than people with APOE3 or APOE2.

Parkinsons is the most common, but there are other, rarer diseases that also are caused by alpha-synuclein aggregation and also have very limited treatment options, Davis said. Targeting APOE with therapeutics might be a way to change the course of such diseases.

APOE doesnt affect the overall risk of developing Parkinsons or how quickly movement symptoms worsen, so an APOE-targeted therapy might stave off dementia without doing anything for the other symptoms. Even so, it could be beneficial, Davis said.

Once people with Parkinsons develop dementia, the financial and emotional costs to them and their families are just enormous, Davis said. If we can reduce their risk of dementia, we could dramatically improve their quality of life.

Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM. APOE Genotype Regulates Pathology and Disease Progression in Synucleinopathy. Science Translational Medicine. Feb. 5, 2020. DOI: 10.1126/scitranslmed.aay3069

This work was supported by an American Academy of Neurology/American Brain Foundation (Clinical Research Training Fellowship); the BrightFocus Foundation; the Mary E. Groff Charitable Trust; the Dobbins Family Fund; the Foundation for Barnes-Jewish Hospital (Elliot Stein Family Fund); the Riney Foundation; the American Parkinson Disease Association; the Greater St. Louis Chapter of the American Parkinson Disease Association; The JPB Foundation; and the National Institutes of Health (NIH), grant numbers K08NS101118, R01AG044546, RF1AG053303, RF1AG058501, U01AG052411, U01AG058922, NS075321, NS097799, R01NS090934 and R01AG047644.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Gene ID'd as potential therapeutic target for dementia in Parkinson's - Washington University School of Medicine in St. Louis

Adverum Biotechnologies Reports New Interim Data from Cohorts 1 and 2 of OPTIC Phase 1 Trial of ADVM-022 Intravitreal Gene Therapy for Wet AMD at…

DetailsCategory: DNA RNA and CellsPublished on Sunday, 09 February 2020 11:42Hits: 258

-- Robust efficacy with evidence of a dose response ---- 6/6 patients rescue-injection-free in cohort 1, with 3 patients at 52 weeks ---- 4/6 patients rescue-injection-free in cohort 2 (lower dose) at 24 weeks --

REDWOOD CITY, CA, USA I February 08, 2020 IAdverum Biotechnologies, Inc. (Nasdaq: ADVM), a clinical-stage gene therapy company targeting unmet medical needs in ocular and rare diseases, today announced new interim clinical data from the OPTIC Phase 1 dose-ranging clinical trial of ADVM-022 intravitreal injection gene therapy. OPTIC includes treatment-experienced patients with wet age-related macular degeneration (AMD). The data are being presented today by David S. Boyer, M.D., senior partner, Retina-Vitreous Associates Medical Group and adjunct clinical professor of ophthalmology with the University of Southern California/Keck School of Medicine in Los Angeles, at the Angiogenesis, Exudation, and Degeneration 2020 Annual Meeting in Miami.

A copy of the presentation is available on the Adverum corporate website under Events and Presentations in the Investors section.

For the first time, data are being presented from patients in cohort 2 (n=6) at 24 weeks following treatment with a single intravitreal injection of a three-fold lower dose of ADVM-022 (2 x 10^11 vg/eye) compared to the cohort 1 dose (6 x 10^11 vg/eye).New data as detailed in the table below include:

OPTIC Phase 1 Clinical Trial Data:

I am very encouraged that this difficult-to-treat patient population enrolled in OPTIC is maintaining vision and anatomical improvements for an extended period of time, said David S. Boyer, M.D., senior partner, Retina-Vitreous Associates Medical Group and adjunct clinical professor of ophthalmology with the University of Southern California/Keck School of Medicine in Los Angeles, California. Additionally, ADVM-022continues to be safe and well tolerated, with ocular inflammation that is manageable with steroid eye drops. Patients with wet AMD and their caregivers carry a significant treatment burden from the current standard-of-care anti-VEGF injections, and real-world vision outcomes are suboptimal due to undertreatment. ADVM-022 as a one-time intravitreal injection therapy could transform the treatment paradigm for patients and their caregivers.

Aaron Osborne, MBBS, chief medical officer of Adverum, added, ADVM-022 has demonstrated a robust efficacy signal and evidence of a dose response in the OPTIC Phase 1 trial with data from 12 patients and two doses now available. Patients in cohort 2 received a three-fold lower dose of ADVM-022 than in cohort 1, and 4 of 6 of these patients are rescue injection-free through 24 weeks, whilst all 6 patients in cohort 1 remain rescue free with a median follow up of 50 weeks. OPTIC is progressing well, with the key objectives for cohorts 3 and 4 being to further evaluate dose response and to assess a 6-week prophylactic course of steroid eye drops instead of the 13-day oral steroid prophylaxis used in cohorts 1 and 2. We look forward to presenting clinical data from all four cohorts of OPTIC during this important year in the clinic for our novel gene therapy, ADVM-022.

KOL Discussion Tomorrow:In addition, Adverum will host an event with expert retinal specialists to discuss the OPTIC data presented at Angiogenesis and the potential opportunity for ADVM-022. The discussion will be held on Sunday, February 9, 2020 beginning at 10:00 am EST. The event will be webcast live from Adverums website at http://www.adverum.com in the Investors section under the Events and Presentations page. A replay of the webcast will be archived and available for replay following the event. A copy of the slide presentation will also available on the Adverum corporate website under Events and Presentations in the Investors section.

About the OPTIC Phase 1 Trial of ADVM-022 in Wet AMDThe multi-center, open-label, Phase 1, dose-ranging trial is designed to assess the safety and tolerability of a single intravitreal (IVT) administration of ADVM-022 in patients with wet AMD who are responsive to anti-vascular endothelial growth factor (VEGF) treatment. In cohort 1, patients (n=6) received ADVM-022 at a higher dose of 6 x 10^11 vg/eye and in cohort 2, patients (n=6) received ADVM-022 at a lower dose of 2 x 10^11 vg/eye. In cohort 3, patients (n=9) also are receiving a dose of 2 x 10^11 vg/eye and in cohort 4, patients (n=9) will receive a dose of 6 x 10^11 vg/eye. Patients in cohorts 3 and 4 will receive prophylactic steroid eye drops instead of oral steroids which were used in cohorts 1 and 2. The primary endpoint of the trial is the safety and tolerability of ADVM-022 after a single IVT administration. Secondary endpoints include changes in best-corrected visual acuity (BCVA), measurement of central retinal thickness (CRT), as well as mean number of anti-VEGF rescue injections and percentage of patients needing anti-VEGF rescue injections. Each patient enrolled will be followed for a total of two years.

Eight leading retinal centers acrossthe United States(U.S.) are participating in the OPTIC Phase 1 trial for ADVM-022. For more information on the OPTIC Phase 1 clinical trial of ADVM-022 in wet AMD, please visithttps://clinicaltrials.gov/ct2/show/NCT03748784.

About ADVM-022 Gene TherapyADVM-022 utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette. ADVM-022 is administered as a one-time intravitreal injection, designed to deliver long-term efficacy and reduce the burden of frequent anti-VEGF injections, optimize patient compliance and improve vision outcomes for wet AMD and diabetic retinopathy patients.

In recognition of the need for new treatment options for wet AMD, the U.S. Food and Drug Administration granted Fast Track designation for ADVM-022 for the treatment of this disease.

Adverum is currently evaluating ADVM-022 in the OPTIC study, a Phase 1 clinical trial in patients 50 years and older with wet AMD. Additionally, Adverum plans to submit an Investigational New Drug Application for ADVM-022 for the treatment of diabetic retinopathy to the U.S. Food and Drug Administration in the first half of 2020.

About Wet Age-related Macular Degeneration (AMD)Age-related macular degeneration (AMD) is a progressive disease affecting the macula, the region of the retina at the back of the eye responsible for central vision. In patients with wet AMD, an aggressive form of AMD, abnormal blood vessels grow underneath and into the retina. These abnormal blood vessels leak fluid and blood into and beneath the retina, causing vision loss.

Wet AMD is a leading cause of vision loss in patients over 60 years of age, with a prevalence of approximately 1.2 million individuals in the U.S. and 3 million worldwide. The incidence of new cases of wet AMD in the U.S. is approximately 150,000 to 200,000 annually, and this number is expected to grow significantly as the countrys population ages.

The current standard-of-care therapy for wet AMD is anti-VEGF intravitreal injections. These are effective but typically require eye injections every 4-12 weeks in order to maintain vision. Compliance with this regimen can be difficult for patients, caregivers, and healthcare systems, leading to undertreatment and resulting in loss of vision.

About Adverum BiotechnologiesAdverum Biotechnologies (Nasdaq: ADVM) is a clinical-stage gene therapy company targeting unmet medical needs in serious ocular and rare diseases. Adverum is evaluating its novel gene therapy candidate, ADVM-022, as a one-time, intravitreal injection for the treatment of its lead indication, wet age-related macular degeneration. For more information, please visit http://www.adverum.com.

SOURCE: Adverum Biotechnologies

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Adverum Biotechnologies Reports New Interim Data from Cohorts 1 and 2 of OPTIC Phase 1 Trial of ADVM-022 Intravitreal Gene Therapy for Wet AMD at...

Here’s Why CRISPR Stocks Fell in January – The Motley Fool

Spurred by promising clinical results in an important trial, each of the three major CRISPR stocks had a great performance in the second half of 2019. Unfortunately, they didn't keep the momentum going in the first month of 2020.

Shares of Intellia Therapeutics (NASDAQ:NTLA) fell 18.8% in January, according to data provided by S&P Global Market Intelligence. That was followed by a 14.7% loss for shares of CRISPR Therapeutics (NASDAQ:CRSP) and a 10.7% tumble for shares of Editas Medicine (NASDAQ:EDIT).

While each has recovered some ground in the first week of February, this trio of pharma stocks is no stranger to volatility. Investors should probably expect that to continue as clinical programs advance in 2020.

Image source: Getty Images.

In November, CRISPR Therapeutics reported data for the first two individuals in the trial, one with sickle cell disease (SCD) and one with transfusion-dependent beta thalassemia (TDT), treated with its lead drug candidate CTX001. Both enjoyed significant benefits in their standard of living, which investors interpreted as a sign that CRISPR gene editing might actually live up to the hype.

That fueled annual gains of 113% for CRISPR Therapeutics last year. While Editas Medicine and Intellia Therapeutics gained only 30% and 7%, respectively, each had been sitting at a year-to-date loss in October.

What relevance does that have for the tumbles taken in January? First, it's not unusual for stocks to regress to the mean. Stocks that are red hot eventually cool off, while those that tumble without good reason eventually recover some ground.

Second, and the more important consideration for investors, is that the early stage results for CTX001 mean relatively little for the industry's pipeline of CRISPR-based gene editing drug candidates.

Consider that CTX001 is an ex vivo tool. Researchers harvest bone marrow from patients, extract specific types of stem cells, and engineer those with CTX001. The engineered stem cells are then grown in the lab before being reinjected into the patient.

Many other CRISPR-based drug candidates are designed as in vivo tools. That means the gene editing payloads are designed to engineer a patient's DNA while inside the body. An in vivo approach is inherently more complex and will be more difficult to control compared to an ex vivo approach.

Put another way, investors cannot take the promising, early stage results from CTX001 and extrapolate it broadly across all first-generation CRISPR tools. Wall Street certainly isn't, if the correlation between technical approach and stock performance is any guide.

Consider that the two most advanced drug candidates from CRISPR Therapeutics rely on ex vivo engineering. By contrast, the lead drug candidate from Editas Medicine relies on in vivo methods.

The lead pipeline asset from Intellia Therapeutics is also an in vivo tool, though unlike the lead assets from its peers, it has yet to advance to clinical trials.

Investors should expect 2020 to be a busy year for these CRISPR stocks. CRISPR Therapeutics will have more clinical data from CTX001 and the first set of data for its lead oncology asset CTX110.

Similarly, Editas Medicine should have results for EDIT101 and progress additional assets, while Intellia Therapeutics is preparing to finally enter the clinic with NTLA-2001 in the second half of the year.

Investors cannot know if the next batch of results will be as rosy as the initial data for CTX001, but they can probably expect another year of volatile stock movements.

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Here's Why CRISPR Stocks Fell in January - The Motley Fool

Largest-Ever Genetic Study of Autism Yields New Insights – The Southern Maryland Chronicle

By: Dr. Francis Collins , National Institutes of Health

Anyone whos spent time with people affected by autism spectrum disorder (ASD) can tell you that its a very complex puzzle. The wide variability seen among individuals with this group of developmental brain disorders, which can disrupt communication, behavior control, and social skills, has also posed a huge challenge for researchers trying to identify underlying genetic and environmental factors. So, its no surprise that theres been considerable interest in the recent findings of the largest-ever genetic study of ASD.

In a landmark study that analyzed the DNA of more than 35,000 people from around the world, the NIH-funded international Autism Sequencing Consortium (ASC) identified variants in 102 genes associated with increased risk of developing ASD, up from 65 identified previously. Of the 102 genes, 60 had not been previously linked to ASD and 53 appeared to be primarily connected to ASD as opposed to other types of intellectual disability or developmental delay. It is expected that this newfound genetic knowledge will serve to improve understanding of the complex biological mechanisms involved in ASD, ultimately paving the way for new approaches to diagnosis and treatment.

The study reported in the journalCellwas led by Joseph Buxbaum, Icahn School of Medicine at Mount Sinai, New York; Stephan Sanders, University of California, San Francisco; Kathryn Roeder, Carnegie Mellon University, Pittsburgh, PA; and Mark Daly, Massachusetts General Hospital, Boston, MA and the Broad Institute of MIT and Harvard, Cambridge, MA. These researchers and their teams faced what might seem like a rather daunting task.

While common genetic variants collectively are known to contribute substantially to ASD, rare variants have been recognized individually as more major contributors to a persons risk of developing ASD. The challenge was how to find such rare variantswhether inherited or newly arising.

To do so, the researchers needed to analyze an enormous amount of DNA data. Fortunately, they and their ASC colleagues already had assembled a vast trove of data. Over the last decade, the ASC had collected DNA samples with full consent from thousands of people with and without ASD, including unaffected siblings and parents. All were aggregated with other studies, and, at the time of this investigation, they had gathered 35,584 unique samples. Those included more than 21,000 family-based samples and almost 12,000 samples from people diagnosed with ASD.

In search of rare genetic alterations, they sequenced whole exomes, the approximately 1.5 percent of the genome that codes for proteins. Their search produced a list of 102 ASD-associated genes, including 30 that had never been implicated in any developmental brain disorder previously.

But that was just the beginning. Next, the ASC team dug deeper into this list. The researchers knew from previous work that up to half of the people with ASD also have an intellectual disability or developmental delay. Many of the associated genes overlap, meaning they play roles in both outcomes. So, in one set of analyses, the team compared the list to the results of another genetic study of people diagnosed with developmental delays, including problems with learning or gross motor skills such as delayed walking.

The detailed comparison allowed them to discern genes that are more associated with features of ASD, as opposed to those that are more specific to these developmental delays. It turns out that 49 of the 102 autism-associated genes were altered more often in people with developmental delays than in those diagnosed with ASD. The other 53 were altered more often in ASD, suggesting that they may be more closely linked to this conditions unique features.

Further study also showed that people who carried alterations in genes found predominantly in ASD also had a better intellectual function. They also were more likely to have learned to walk without a developmental delay.

The 102 new genes fell primarily into one of two categories. Many play a role in the brains neural connections. The rest are involved primarily in switching other genes on and off in brain development. Interestingly, they are expressed both in excitatory neurons, which are active in sending signals in the brain and in inhibitory neurons that squelch such activity. Many of these genes are also commonly expressed in the brains cerebral cortex, the outermost part of the brain that is responsible for many complex behaviors.

Overall, these findings underscore that ASD truly does exist on a spectrum. Indeed, there are many molecular paths to this disorder. The ASC researchers continue to collect samples, so we can expect this list of 102 genes will continue to expand in the future.

With these gene discoveries in hand, the researchers will now also turn their attention to unraveling additional details about how these genes function in the brain. The hope is that this growing list of genes will converge on a smaller number of important molecular pathways, pointing the way to new and more precise ways of treating ASD in all its complexity.

Reference:

[1]Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium, Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Brglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD.Cell. 2020 Jan 23. {Epub ahead of print]

Links:

NIH Support: National Institute Mental Health; National Human Genome Research Institute

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Largest-Ever Genetic Study of Autism Yields New Insights - The Southern Maryland Chronicle

QIAGEN Launches FFPE and Liquid Biopsy PIK3CA Diagnostics in Europe to Enhance Precision Medicine in Advanced Breast Cancer – Business Wire

GERMANTOWN, Md. & HILDEN, Germany--(BUSINESS WIRE)--QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced the CE-marking and launch of its therascreen PIK3CA RGQ PCR Kit in Europe as an aid in identifying breast cancer patients with a PIK3CA mutation. Last year the therascreen PIK3CA test was approved by the FDA and launched as a companion diagnostic test for Piqray (alpelisib) in the US.

The therascreen PIK3CA test is a new diagnostic assay for detection of activating mutations in the phosphatidyl 3-kinase catalytic subunit alpha (PIK3CA) gene, and the first to enable testing of both DNA from FFPE tissue or plasma specimens. All QIAGEN therascreen PIK3CA tests leverage QIAGENs worldwide co-exclusive license from Johns Hopkins University for PCR-based companion diagnostics based on detection of mutations in the PIK3CA gene.

1 in 8 women in Europe will develop breast cancer before the age of 85, making it the most common form of cancer in female patients. The therascreen assay detects 11 clinically actionable PIK3CA mutations, which are estimated to be present in approximately 40% of hormone receptor-positive, human epidermal growth factor receptor-2 negative (HR+ HER2-) advanced breast cancer cases.

This launch in Europe further underscores our commitment to support patients with breast cancer, the most common cancer in female cancer patients, with an estimated incidence of 562,500 in Europe in 2018 according to the WHO said Jonathan Arnold, Vice President, Head of Oncology and Precision Diagnostics. We are convinced that our therascreen PIK3CA Kit, which expands our market-leading therascreen portfolio of companion diagnostics, will provide a valuable testing option for those seeking new ways to combat advanced breast cancer. We are committed to making the therascreen PIK3CA Kit available immediately so that leading laboratories in Europe can provide patients with the test as soon as possible.

Please find the full press release here

Additional information can be found at http://www.qiagen.com/cmp/mdx/pik3ca-rgq-pcr-kit-row/

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QIAGEN Launches FFPE and Liquid Biopsy PIK3CA Diagnostics in Europe to Enhance Precision Medicine in Advanced Breast Cancer - Business Wire

AI IN MEDICAL DIAGNOSIS: How top US health systems are reacting to the disruptive force of AI by revolutionizi – Business Insider India

AI is rocking medical diagnosis with its potential to incite drastic improvements to hospital processes. AI can process images and patient health records with more accuracy and expediency than humans are capable of, lessening physician workload, reducing misdiagnosis, and empowering clinical staff to provide more value.

While early moving hospitals are already extracting value from AI in medical diagnosis, most US hospitals are at the very early stage of the AI transformation curve - and they risk falling behind if they don't move now.

In this report, Business Insider Intelligence examines the value of AI applications in three high-value areas of medical diagnosis - imaging, clinical decision support, and personalized medicine - to illustrate how the tech can drastically improve patient outcomes, lower costs, and increase productivity.

We look at US health systems that have effectively applied AI in these use cases to illustrate where and how providers should implement AI. Finally, we examine how a leading US health system validates AI partners and internally organizes its AI strategy to offer provider organizations a template for AI innovation.

The companies mentioned in this report are: Aidoc, Allscripts, Amazon, Arterys, Boston Gene, Cabell Huntington Hospital, Cerner, Cleveland Clinic, Epic, Geisinger Health System, Google, HCA Healthcare, IBM, iCAD, IDx, Intermountain Healthcare, Johns Hopkins, Meditech, Microsoft, Mount Sinai, NorthShore University HealthSystem, Oak Street Health, Stanford University, Tempus, UCI Health System, Unanimous AI, Verily, Viz.ai, and Yale New Haven Hospital.

Here are some of the key takeaways from the report:

In full, the report:

Want to learn more about the fast-moving world of digital health? Here's how to get access:

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AI IN MEDICAL DIAGNOSIS: How top US health systems are reacting to the disruptive force of AI by revolutionizi - Business Insider India

In My Country, Sex Is Still Taboo, and Not Talking About It Has Made Things Worse – POPSUGAR

When I was in fifth grade back home in the Dominican Republic, I had "the talk" with my mom. It might seem a little young, but our school was teaching us about human reproduction, and they had told the parents that they would address the biological part of it, but the parents had to sit down with us and go over the fact that people didn't necessarily do it for human reproduction purposes.

For me, the talk was very positive. My mom has always been very straightforward and has made sure that I trust her enough to reach out to her with any questions or concerns. But I knew that wasn't the case with everyone. And as I grew older and actually hit puberty, the chat around sex became all about abstinence rather than "this is how you can protect yourself."

Let's be honest: if you tell any teenager that they're not allowed to do something, they will want to do it even more. But then, in a country like the Dominican Republic, you also had the church's influence dictating how people particularly women should live their lives.

The church and the state are pretty much one entity there's no real separation. So, when it comes to issues such as allowing women to choose what to do with their bodies, or even teaching sex ed in schools, there's an automatic push against it because "that's not how God wanted it."

They vilify sex, making it seem like the ultimate sin when done outside of the "sacred bond of marriage." They limit access to information to vulnerable people, the ones who only have access to a church in their community, and as a result, we have a teenage pregnancy crisis.

Human Rights Watch reported in a study that the Dominican Republic has the highest adolescent fertility rate of all of the countries in Latin America and the Caribbean, according to the Pan American Health Organization (PAHO).

"While some adolescent pregnancies are planned and wanted at the time they occur, many are not. The total ban on abortion in the Dominican Republic means adolescent girls facing unwanted pregnancies must choose between clandestine and often risky abortions or the lifelong consequences of having a child against their wishes."

The study goes on to list the consequences of this crisis, starting with serious health risks not only for the mother but also the baby, difficulty for the expecting mother to continue her education despite a law that prohibits expulsion of pregnant girls from school which then cuts back even more on her chances for a better life for her and her child. In most cases, the girls end up trapped in a never-ending poverty cycle, which then traps their babies when they're born. And it doesn't help that in many parts of the DR, there's no place girls can gain access to confidential, nonstigmatizing, adolescent-friendly sexual and reproductive health services.

"The Dominican Republic is one of few countries in Latin America and the Caribbean where abortion is criminalized and prohibited in all circumstances, even for women and girls who become pregnant from rape or incest, whose lives are endangered by pregnancy, or who are carrying pregnancies that are not viable, meaning the fetus will not survive outside the womb," The Human Rights Watch study continued.

Girls, particularly those from poor and rural communities, suffer the consequences of these policy failures most profoundly, and that's why it's so important to provide information, talk about sexual and reproductive health, foment sexual education in schools, expand health services and providers who aren't judgmental, decriminalize abortion, and give girls and women the option to safely end their pregnancies.

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In My Country, Sex Is Still Taboo, and Not Talking About It Has Made Things Worse - POPSUGAR

34 foods that ramp up your sex drive and they taste freakin’ amazing too – Health24

Sex drive foods, you say? A myth, you say? Not so fast. These 34-plus edibles are not only good for you, theyll rev up your libido and boost blood flow to the genitals, taking sex from ordinary to extraordinary Just in time for Valentines Day. Wink.

Spinach is a potent source of magnesium, which helps dilate blood vessels, according to Japanese researchers. Better blood flow to the genitals creates greater arousal for men and women. Spinach and other green veg, like broccoli, Brussels sprouts, kale, cabbage, Swiss chard and bok choy, are also good sources of our favourite sex nutrient folate. Extra insurance for good reproductive health, folate may lower blood levels of homocysteine (high levels are a risk factor for peripheral arterial disease).

The antioxidant catechin found in tea promotes blood flow all over the body for sex power and brainpower; it enhances memory, mood and focus. One particularly potent catechin, a compound called ECGC prevalent in green tea, is thought to increase fat burn. Drink freshly brewed green or black tea every day hot or iced.

One study shows that vitamin C may increase libido in women. Another finds that people who eat foods high in vitamin C report better moods and have more sex. It also helps boost blood flow, meaning that both sexes can get friskier, faster. Note: men who consume at least 200mg of vitamin C a day improve their sperm counts and motility, according to research at the University of Texas Medical Branch.

Grapefruit contains 120 percent of the recommended daily allowance of 90mg of vitamin C for men. Other excellent sources are kiwi, mango, oranges, spanspek, strawberries, broccoli, tomatoes, leafy greens and ascorbic acid supplements. And watermelons. Theyre filled with high concentrations of lycopene, beta carotene, and, the big one, citrulline, which is particularly exciting for its ability to relax blood vessels, the same basic effect that Viagra has.

READ MORE: These Libido-Boosting Foods Amp Up Blood Flow Where It Counts *Wink*

Their nutrients, including folate, iron, phosphorus and selenium, are heart healthy and also known to maintain the health of epithelial tissues, which line the vagina and uterus in women. Eggs are rich in vitamins B6 and B5, which help balance hormone levels and ease stress, and are important for a healthy libido.

Italian researchers found that women who drink red wine in moderation enjoy higher levels of sexual interest and respond with more lubrication than women who dont drink or drink less. The researchers believe that the antioxidants and alcohol in the wine may trigger the production of nitric oxide in the blood, which helps artery walls to relax, increasing blood flow to the genitals. Just limit yourself to a glass or two. More alcohol than that can put a damper on sexual performance.

Worth noting: even teetotallers can benefit from the red grape. Dark grape juice contains antioxidant polyphenols that protect the cardiovascular system and help keep skin flexible and elastic.

That brings us to the meat of this entry. Red meat. Lean cuts are great sources of zinc, a mineral that curbs production of a hormone called prolactin, which, at high levels, can cause sexual dysfunction, according to Berman.

Pumpkin and sunflower seeds, almonds, peanuts, walnuts and other nuts all contain the necessary monounsaturated fats with which your body creates cholesterol and your sex hormones need that cholesterol to work properly.

Thats something the ancient Romans didnt know when they tossed walnuts at newlyweds for good breeding luck. Long linked to fertility the shell, of course, resembles a mans cojones; the inside meat is vulva-like in form nuts make a perfectly sexy snack. Packed with muscle-building protein and filling fibre, they are a heart-healthy, albeit kilojoule-dense, treat.

READ MORE: 6 Superfood Powders Thatll Give Your Body A Boost

How do you eat more protein without going overboard on eggs and meat? Beans. Many studies show that bean eaters are leaner and healthier than people who dont eat beans. According to one study in the Journal of the American College of Nutrition, people who eat three quarters of a cup of beans or legumes a day have lower blood pressure and smaller waists than people who get their protein from meat. Beans are also full of cholesterol-lowering soluble fibre. A quarter cup of red kidney beans delivers three grams of fibre, plus more than 6 000 disease-fighting antioxidants.

If, as doctors like to say, whats good for your heart is good for your love life, oily cold-water fish, like salmon, mackerel, sardines and tuna, should figure heavily into your weekly meal rotation. The omega-3 fatty acids DHA and EPA found in fish help to raise dopamine levels in the brain that trigger arousal, according to sexologist Dr Yvonne Fulbright. Fish contains the amino acid L-arginine, which stimulates the release of growth hormones and is converted into nitric oxide in the body. Its worth repeating: nitric oxide is critical for erections and it can help womens sexual function as well by causing blood vessels to open wider for improved blood flow.

Eating oats is one of the few natural ways to boost testosterone in the bloodstream. The male hormone plays a significant role in sex drive and orgasm strength in both men and women. Oats (as well as seeds, ginseng, nuts, dairy and green vegetables) contain L-arginine, the amino acid that enhances the effect nitric oxide has on reducing blood-vessel stiffness. Like Viagra, it helps relax muscles around blood vessels in the penis. When they dilate, blood flow increases so a man can maintain an erection. Studies show that L-arginine also improves blood flow to the clitoris and tissue surrounding the vulva.

READ MORE: 7 Ways To Make Overnight Oats Way, Way Better

In addition to their reputation as the ultimate aphrodisiac (thanks to their resemblance to female genitalia), raw oysters actually do have a connection to sexual function. Oysters hold more zinc than most other foods and it is believed that this mineral may enhance libido by helping with testosterone production higher levels of the hormone are linked to an increase in desire. Zinc is also crucial to healthy sperm production and blood circulation. While Casanova reportedly ate 50 raw oysters a day, about six will provide double the recommended daily allowance of 15mg of zinc. Other good sources of zinc are shrimp, red meat, pumpkin seeds, poultry and pork, eggs and dairy products.

Devouring something gooey and decadent is incredibly sensual. Dark chocolate, in particular, contains a compound called phenylethylamine that releases the same endorphins triggered by sex and increases the feelings of attraction between two people, according to research published in the Journal of the American Dietetic Association. In fact, brain scans in a British study showed that eating chocolate causes a more intense and longer brain buzz than kissing does.

Chocolate does also appear to boost heart health. Scientists at the Harvard University School of Public Health examined 136 studies on cocoa and found heart-health benefits from increased blood flow, less platelet stickiness and reduced bad cholesterol. Whats the healthiest chocolate? The disease-fighting flavonols that make dark chocolate good for the body also cause the bitterness. To balance flavour and health benefits, try dark chocolate with 70 percent cacao, recommends Dr Jeffrey Blumberg, who directs the Antioxidants Research Laboratory at Tufts University in the US. A five-centimetre square chunk, at about 400kJ, will deliver a healthy treat without messing with your weight-management efforts.

Red is sexy. But strawberries are sex drive foods for another reason besides their sensual colour: they are high in the B vitamin, folate, which helps prevent birth defects, and vitamin C, a potential libido booster. Blueberries (and blackberries) are just as sexy. Ideal for a great morning-after breakfast in bed, so you have energy for round two, both berries contain compounds that are thought to relax blood vessels and improve circulation for a natural Viagra-like effect.

READ MORE: Vegan Strawberry Smoothie Bowl, Plus More Breakfast Recipes

The ancient Aztecs called them testicles. Hanging in pairs from trees, the fruit is so suggestive that Catholic priests in Spain once forbade parishioners from eating them. But beyond their shape, avocados have a strong connection to the testes, the production centre of sperm, due to their high folate content. Men planning to have children should consider loading up on avocado (as well as leafy greens) because folate may protect sperm from mutations. A study at the Lawrence Berkeley National Laboratory in a 2008 issue of the journal Human Reproduction analysed the sperm of 89 men for chromosome abnormalities and then compared the results to a food frequency questionnaire the men completed. The researchers found that men with the highest folate intake had the lowest frequency of sperm with extra chromosomes compared with men who had lower consumption.

This phallic vegetable has been associated with sex since the first hunter-gatherer spotted shoots popping out of the forest floor and cried, Hey, you know what those remind me of? The springtime shoots are loaded with B vitamins that increase levels of histamine, a neurotransmitter that facilitates orgasm. Green asparagus spears are rich in rutin, a potent scavenger of free radicals. The crowns also have high levels of the chemical protodioscin which may improve sexual function. Protodioscin has been shown to boost arousal and even help combat erectile dysfunction in some men, says Dr Lynn Edlen-Nezin, co-author of Great Food, Great Sex.

If you suffer from a bit of sexual anxiety, eat a banana before you hook up. Bananas deliver the feel-good neurochemical serotonin into the blood stream, which elevates mood and calms the nervous system. Bananas contain potassium, a mineral that increases muscle strength, an element crucial to orgasm, says Lou Paget, author of The Great Lover Playbook.

READ MORE: Should You Avoid Bananas If Youre Trying To Lose Weight?

Fortified breakfast cereals and breads contain niacin, a vitamin thats essential for the secretion of histamine, a chemical our bodies need in order to trigger explosive sneezes and orgasms. They are high in thiamin and riboflavin too, vitamins that help you use energy efficiently and that are important for proper nerve function, which translates into more stimulation and pleasure during sex.

Every stalk of this Bloody Mary swizzle stick is packed with androstenone and androstenol, two pheromones that can help men attract women. When you chew a stalk of celery, you release androstenone and androstenol odour molecules into your mouth. They then travel up the back of your throat to your nose, says Dr Alan Hirsch, author of Scentsational Sex: The Secret to Using Aroma for Arousal. Once there, the pheromones boost your arousal, turning you on and causing your body to send off scents and signals that make you more desirable to women.

One of the first body parts the opposite sex looks at when scoping out a potential date: the teeth. Keep them bright and healthy by eating cheese. Cheese is a good source of calcium, to keep your teeth strong, plus it can lower the levels of bacteria in your mouth and keep teeth clean and cavity-free. The American Dental Association recommends eating at least two servings of block cheese every week to maintain tooth health.

Smokin sex drive foods! Chillies contain the chemical capsaicin, which triggers the release of endorphins. It also stimulates nerve endings, increasing metabolism, raising your heart rate, causing flushed cheeks, sweating and other physical effects that mimic arousal.

While coffees association with sex drive foods is tenuous, caffeine has been shown to have health benefits. After a sip of a caffeinated beverage, the brain releases dopamine, a neurochemical that stimulates areas of the brain responsible for alertness, problem solving and pleasure. A cup before a workout has been shown to help athletes exercise longer and harder. And although researchers dont know exactly why, they speculate that the large amounts of antioxidants in coffee and other compounds in caffeine may be responsible for improved insulin resistance and reduced diabetes risk.

Considering their resemblance to female genitalia (when sliced in half), its no surprise figs are historically lauded as sex drive foods. The ancient Greeks are said to have celebrated the arrival of the fig crop with wild sex rituals and the great seductress Cleopatra loved to eat them from the fingers of buff young male attendants. Nutritionally, figs make sense as a sex snack. Like blueberries, they contain more soluble and insoluble fibre than most fruit and vegetables and they are rich in many nutrients important to good sexual health, including potassium, magnesium, iron, manganese, calcium and antioxidants. High in simple sugars, a quarter-cup serving will boost your serotonin levels and provide a quick energy lift.

READ MORE: 7 Health Benefits Of Spicy Food Every Hot Sauce Lover Needs To Know About

Sprinkle flaxseeds on your cereal, yoghurt or ice cream for a shot of omega-3 and omega-6 fatty acids, which are the major building blocks of all sex hormones. One tablespoon of the nutty-tasting seeds helps increase testosterone, the chemical with the most direct libido-boosting effect, according to sexuality researcher Dr Helen Fisher. Another good plant-based source of these essential fatty acids is walnuts.

Garlic may be the last thing you want on your breath when youre ready to have sex. But it may be something you want to get more of on other occasions due to its high concentration of the compound allicin. Numerous small clinical studies suggest that regular garlic consumption may reduce cholesterol, blood pressure and risk of certain cancers and work against peripheral artery disease, improving blood flow particularly to the lower extremities.

Honeys B vitamins aid the production of testosterone and its boron content helps the body use oestrogen, which is a key factor in proper blood flow and arousal. In the kitchen, drizzle it on your oats. In the bedroom, drizzle it on any warm, lickable surface.

The calcium in milk is essential for bone building. The vitamin D in fortified milk helps calcium keep your muscles, heart and nervous system humming. Studies show that calcium also influences fat metabolism. Yoghurt is another great source of calcium. But when choosing your yoghurt, reach for the probiotic kind. Hint: the label will read live and active cultures. This yoghurt contains beneficial organisms that work with the bacteria in your gut to boost your immune system. Whats more, yoghurt is one of the few foods with conjugated linoleic acid, a special type of fat that some studies show can reduce body fat.

There are a lot of reasons to eat and drink more of this fruit. When scientists at the University of California studied the pomegranate, they found that it is rich in polyphenols, antioxidants that allow blood to flow through your veins a key component of good sex. And Israeli researchers discovered that men who drank 60ml of pomegranate juice a day for a year lowered their systolic blood pressure by 21 percent and dramatically improved blood flow to their hearts.

Your skin is your largest sex organ. Keep it soft, supple and wrinkle-free by limiting exposure to the sun, one of the primary reasons men and women age prematurely. In addition to applying sunscreen, ingest some SPF by eating sweet potatoes. European researchers found that pigments from beta-carotene-rich foods like sweet potatoes and carrots can build up in your skin, helping to prevent damage from ultraviolet rays.

This article was originally published on http://www.womenshealthsa.co.za

Image credit: iStock

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34 foods that ramp up your sex drive and they taste freakin' amazing too - Health24

Scientists are racing to model the next moves of a coronavirus that’s still hard to predict – Science Magazine

This model shows the most probable routes that the novel coronavirus will take tospread from the international airport in Beijing to airports around the world. Bubble size represents relative risk at each airport.

By Jon CohenFeb. 7, 2020 , 6:15 PM

Beyond China itself, Thailand is the country that most likely will have people who arrive at one of its airports with an infection by the novel coronavirus (2019-nCoV) that has sickened more than 30,000 people. So says the latest update of a global risk assessment model created by a team of researchers from the Humboldt University of Berlin and the Robert Koch Institute that relies on air travel data.

Next on the teams list is JapanOsakas international airport, interestingly, is more at risk than Tokyoswhich is followed by South Korea, Hong Kong, and then the United States. Russia likely has more infected people flying in than India, Germany (mainly the Frankfurt and Munich airports) is the most vulnerable country in Western Europe, and Ethiopia is the only sub-Saharan African country to break into the top 30 of virus-threated countries.

So, how seriously should this model, and the dozens of other computer simulations of the outbreak, be taken? Scientists studying the 2019-nCoV outbreak are getting plenty of data to groundtruth and tweak their models. As of yesterday, for example, the most confirmed cases outside of mainland China were in Japan (45), Singapore (28), Thailand (25), Hong Kong (24), and South Korea (23). That could be considered a partial success for the Berlin model, but it also reflects that this is a dynamic outbreak that upends assumptions at a blinding speed; for example, the airport in Wuhan, China, the outbreaks epicenter, was closed on 23 January, which radically altered airline exportation of the virus, and today there are 61 confirmed cases on a cruise ship off the coast of Japan.

This is not so much a tool for making quantitative predictions, says Dirk Brockmann, a physicist at Humboldt who leads the modeling team. Public health officials and policymakers have to develop an intuition because this virus is something unknown. Models can help you develop an intuition.

A flurry of models of the 2019-nCoV outbreak have been shared on websites, preprint servers, and in peer-reviewed journals, and many attempt to do far more than just sharpen hunches about where infected air travelers are going to land. If they have robust enough data, models can forecast the rate at which an outbreak will grow and help predict the impact of various interventions. When you start to include disease dynamics and population information, theres more information than just intuition, says Alessandro Vespignani, an infectious disease modeler at Northeastern University.

The centerpiece of many outbreak/infectious disease/pathogen models is the basic reproduction number, or Ro (pronounced R zero or R naught). Its essentially how many people each infected person can infect if the transmission of the virus is not hampered by quarantines, face masks, or other factors. Modelers also look at the incubation time, which is how long it takes for the virus to cause symptoms. The serial interval factors in the time between a person developing symptoms and a contact becoming ill. In this young outbreak, unknowns riddle every model. The current estimate for 2019-nCoVs incubation time has been hard to pin down with the U.S. Centers for Disease Control and Prevention suggesting theres a range of 2 to 14 days. There are many things that should be carefully weighted at this point, and thats why the modeling has difficulties, Vespignani says.

One of the first models to come outby a group at Imperial College London on its website on 17 Januarylooked at confirmed infections outside China to infer the number of infections that likely had occurred in Wuhan. At the time the group released that model, Wuhan had only reported that 41 illnesses were caused by the virus, and the model estimated that by 12 January, the infection had actually sickened 1723 people in the city. Those estimates, which were startling at the time, seem quaint now: As of 5 February, there were 27,619 confirmed cases, and a modeling study by the University of Hong Kongs Joseph Wu and colleagues that was published online by The Lancet on31 January estimated that Wuhan alone had 75,815 cases by 25 January.

Many of the early calculationsincluding the initial airport analysis done by Brockmanns team (which does daily updates)lost all meaning after Wuhan shut down public transportation. That was just over 2 weeks ago, which seems like 2 years ago now, Vespignani says.

One of the most vexing mysteries at the moment that can undermine modeling is whether people with 2019-nCoV who do not have symptoms can transmit an infection. Its possible that there are infected people who never become ill but still transmit. There also may be infected people who transmit before they develop symptoms. Most of the fate of the epidemic is in this element, Vespignani says.

The viral diagnostic tests being used to confirm cases now typically are only done on people seeking care because they are ill. One way to find asymptomatic or presymptomatic cases is to examine peoples blood for signs of an immune response to 2019-nCoV. To know the full extent of spread youd like to collect blood samples from contacts of infected people and do the same 2 weeks later and see if theyve developed antibodies to the virus, says Marion Koopmans, whose team at Erasmus Medical Center is racing to develop an antibody test for 2019-nCoV. That gives you a better estimate of spread without symptoms.

Models may also become sharper as researchers have a finer understanding of the epidemiology of infected cases, which means details about their location, health, age, and gender. Those data can help modelers make more reliable assumptions about factors like incubation time. To that end, computational epidemiologist Moritz Kraemer at the University of Oxford has spearheaded an unusual effort to compile a line list of confirmed cases by sifting through government reports, the medical literature, reliable media accounts, and social media. Line lists contain incredibly useful information that are not visible in aggregated case counts, Kraemer says. Unfortunately, line list data are rarely available during outbreaks and until now only routinely collected by governments that do not share them openly.

This line list, which has more than 15,000 cases on it now, documents everything thats public about infected individuals. His group has already used the data in a study that assesses the capacity of countries in Africa to detect and respond to cases; two of the five most vulnerable countries on the continent, Ethiopia and Nigeria, have what they call variable capacity to respond to the outbreak. A modeling study by a different group used the data to assess transmission dynamics, concluding that once a place has three cases, there is more than a 50% chance the virus can become established in the population.

On top of needing better data, models also suffer from how their forecasts are interpreted by journalists or the public. Robin Thompson, a mathematical epidemiologist at Oxford who has modeled the outbreak, contends many news stories have garbled descriptions of Ro, the basic reproduction number, and exaggerated the risk of spread. Its being misused in this outbreak, Thompson says.

Most estimates for 2019-nCoV calculate that Ro is between two and threethat an infected person will infect two or three others. But this is just an average. Some infected people, by chance, wont transmit the virus to anyone else. The real question from a population standpoint is what is the probability with an Ro of, say, 2.2, that there will be sustained transmission of the virus? With this new virus, Thompson calculates theres a 54.5% chance of sustained spread starting from a single infected person if nothing, for example a vaccine, prevents transmission.

Ro does not change during an outbreak: A virus has a certain, fixed contagiousness factormeasles, for example, more easily spreads between people than influenza. But even in the absence of a vaccine, human behavior and the environment itself can alter the likelihood of spread. Hospitals isolate infected people or they choose to stay home. A further decrease also often occurs as an outbreak matures and many people become immune because of previous exposure, reducing the number of susceptible hosts. Hand washing, wearing protective garb, and social distancing can also reduce transmission rates. A climactic shift, like winter becoming spring, may affect the ability of a respiratory virus to transmit through the air.

In the lingo of modelers, what matters most is not the unchanging basic reproduction number of Ro, but what they somewhat unimaginatively refer to as the reproduction number, or R, that factors in these other variables. R is constantly in flux. Heres an example of R, expressed as a percentage: Thompson calculates that if 50% of infected symptomatic people are isolated and 20% are asymptomatic, then the risk of sustained transmission is 24.2%.

The take home message from this R analysis is that countries other than China still have a good chance of containing 2019-nCoV. Early on in an outbreak, you can take advantage of the fact that theres this probability of the thing fading out, Thompson says. And if you can isolate the few infected people you have very quickly, then the probability of this fading out is much higher.

Ultimately, models are a science-based attempt to inform public health policy. Take travel restrictions. Wu says he doubts that restricting travel from Wuhan will have any impact on spread within China at this point. He points to calculations by an international team of scientists that the Wuhan travel restrictions, which those researchers described as the largest quarantine in human history, delayed spread to other cities in China by just 2.91 days. Keeping Wuhan locked down now would not make a difference for [epidemiological] curves for other cities in China now, Wu says. Now, social distancing there is essential.

Hong Kong, which has 24 confirmed cases to date, waited until today to close its own borders to people from mainland China. The public had asked the government to reduce the flow from the mainland, and the government had different reasons for not wanting to do that, Wu says. Public health is a priority, but the economy is also a major concern. If it cuts people flow, it can also cut the supply chain of necessary products to Hong Kong.

So the balance between public health and politics factor in to 2019-nCoVs spreadwhich means a refined understanding of Ro and R, incubation time, the serial interval, and other variables can only sharpen a models predictive powers to a point. As most every honest modeling paper cautions, There are limits to this analysis.

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Scientists are racing to model the next moves of a coronavirus that's still hard to predict - Science Magazine

There Are Worms In Space – Forbes

C. elegans is a tiny, transparent nematode worm that responds to space conditions in ways similar to ... [+] human responses.

Astronauts arent the only ones living on the International Space Station. There are lab rats in space, plants in space, and yes, there are worms in space too. Space worms!!

Caenorhabditis elegans, a nematode worm, is used for studying biology in space because this worm shares many essential biological characteristics of human biology and is a common, well-studied organism used in biomedical research as a model for human development, genetics, aging and disease.

C. elegans starts out as a single cell just like us. It has a transparent body so its cells are visible with a microscope. These worms breathe air from the Space Station environment via a series of ventilation holes in their housing container. In just 2-3 weeks, they undergo a complex process of development, with embryonic cleavage, morphogenesis and growth into the adult. C. elegans has a nervous system with a 'brain', muscles and a gut. They produce sperm and eggs, and reproduce as hermaphrodites. These worms are also capable of rudimentary learning. After reproduction, the worms gradually age, lose vigor and finally die.

C. elegans is currently being used to investigate the effects of radiation and microgravity on muscle anatomy to understand the influence of spaceflight on muscle physiology. These investigations help researchers understand how the human body loses muscle mass while living in microgravity because loss of muscle mass and performance is a problem for astronauts on future human space exploration missions.

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There Are Worms In Space - Forbes

Worms in the stomachs of locusts create fear among Kuwaitis – ARAB TIMES – KUWAIT NEWS – Arab Times Kuwait English Daily

KUWAIT CITY, Feb 8: Kuwaitis generally pass their time eating locusts and enjoying their taste as a healthy snack which doesnt cause any diseases to human body as it feeds on wild herbs and wild plants, and the old people use to wait for coming of locuts because it was a cheap food reports Al Rai

But this confidence finally turned into fear, panic and a warning not to eat it, after a video appeared showing a person offering to remove a worm from the stomach of Locust, warning that eating it would cause poisoning, which puzzled those waiting for the season to enjoy his taste.

As per Dr. Jinan Al-Harbi as researcher in Entomology confirmed that the video circulated regarding locust worms is true and realistic, indicating that locusts can be a carrier of many microorganism, including fungi, viruses and bacteria. She further stated what we see inside the locusts stomach is the larva of one of the insects that may have entered by eating the locust for plants loaded with eggs of this insect and this is the only explanation for the existence of the worm.

Al-Harbi further stated that there is a type of parasite known as horse nematode (worm) that lives in the stomach of locusts and is harmful and causes its death, but its shape is completely different from what is found in the spread video, indicating that the larva in the insects abdomen may be a blue fly or one of insects such as a beetle and may be It is fatal to the locust because it feeds on its internal gut, but its secretions and excreta are harmful to humans, and it may cause intestinal infections and poisoning.

She also said that she is not sure that all locusts have this worm because we need to do a random examination of a group of locusts, but care is necessary and care must be taken and stop eating the locusts at the present time.

Locust carries a worm, symptoms appear only in its final stages when the larva wipes out its inner gut and becomes black, as it leads to impaired blood circulation and vital functions and is not edible, but if a person eats it while it is loaded with worms, it is normal to be poisoned and symptoms of vomiting is noticed.

As per Dr. Jinan Al-Harbi there are 20,000 species of locusts and varies according to the environment in which they live, considering that locusts are types of grasshoppers that have strong back legs that help him jump for long distances equivalent to 20 times his body length. She explained that the desert locusts are the most dangerous and the most influential on our region, as it is spread in Africa, Mauritania, Morocco and Sudan, and moves through the Red Sea to the Arabian Peninsula and from there to Iran, Iraq and Syria, and locusts reproduce at a tremendous speed, where the female can lay 95 to 158 eggs at a time One at least three times during its life cycle.

Al-Harbi reported that desert locusts feed on plants, so we find its spread is associated with rainy seasons, while its absence and its reproduction in dry seasons are weak.

The Desert Locust was considered one of the favorite foods of some peoples in Asia and the Arab countries, especially Saudi Arabia, Kuwait and Yemen, as it works to revitalize the body because it feeds on wild, aromatic and natural plants as it is one of the most effective tonic and stimulants and helps in treating rheumatism and back pain. It is also rich in protein, fats and organic materials such as manganese, calcium, iron, sodium, potassium and phosphorous.

Locusts should be avoided after spraying them with pesticides, as they are exposed to poisoning, as they destroy agricultural crops, and cause huge losses in the agricultural sector and the economy.

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Researchers emphasise that bumble bees need biodiversity – Open Access Government

Bees are an important factor for our environment and our sustenance. Without insect pollination, many plant species including various crops cannot reproduce.

A UK researcher, studying the survival of bees at the University of Sheffield, spoke to us about the situation. She said:

Extensive landscape change causing the destruction of biodiverse green spaces in favour of concrete have resulted in the depletion of essential bumblebee foraging resources such as wildflowers and fruit trees.

As bumblebees are a key pollinator, the resulting declines of bumblebee populations have severe cascading effects on our ecosystems.

The feeding habits of these insects are crucially important to the eating habits of the human being. Globally, more than 20,000 bee species need to be considered. Among these, bumble bees are of particular importance besides the famous honey bee.

Professor Sara Leonhardt, who specialises in plant-insect interactions, said:

Bee mortality therefore affects food supply for human beings.

Bees obtain most of their nutrients from their main food sources, which are nectar and pollen. While nectar is mainly a source of carbohydrates, pollen contains most of the other necessary nutrients: proteins, fat, minerals and vitamins. Until today, most bee researchers assumed that bees, like other herbivores, mainly consider the protein content when choosing their food.

Using a two-step mechanistical approach that included learning and feeding experiments, the group established a new way to literally keep a close eye on the feeding habits of insects.

Which nutrients can bumble bees taste in pollen?

As a first step, learning experiments helped the scientists to establish the bumble bees preference for certain nutrients in this case fat and protein.

Fabian Rdenauer, main author of the study, explained:

We are focusing on fatty and amino acids, which represent the two essential pollen macro nutrients and which are likely to be perceived and thus tasted by bees.

In this context, a small amount of fatty acids was added to pollen to increase its fat content. The researchers found that bumble bees could clearly differentiate between normal pollen and pollen with increased fat content and did show a clear preference for normal pollen. Surprisingly, the bumble bees made no clear distinction when the pollen amino acid content was altered in the same way.

Which nutrients actually affect the bumble bees foraging behavior and what are the consequences for their survival and reproductive capabilities? Those were the central questions guiding the subsequent feeding experiments.

The more fat the pollen contained, the less the bumble bees consumed that pollen, Leonhardt concluded. Bumble bees actually accepted death over having to consume the high-fat pollen. The work group therefore concluded that fat in pollen adversely affects the bumble bees reproductive capabilities and survival, which is why it is being avoided.

Similar to the learning experiment, variations in the amino acid content of pollen did not affect the bees feeding habits, survival or reproduction.

Our study highlights the importance of fat for foraging bumble bees. It also shows that there is a correlation between nutrient perception, nutritional regulation and reproductive fitness, stated Dr. Johannes Spaethe from the University of Wrzburg, who also led the study.

The bees can taste what is good for them and collect their food accordingly, said Leonhardt, summarising the results.

Currently, the researchers are creating a dataset on pollen nutritional chemistry in order to obtain an overview across the wide spectrum of different plant species. They are also examining the nutritional needs of other species of bees.

The research team said:

In the future, this may lead to better understanding the effect of variation in flowering plant species on bees, and it may improve protective measures such as flower strips in agricultural landscapes.

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Researchers emphasise that bumble bees need biodiversity - Open Access Government

Delhi elections: Which campaign brain will win? – Economic Times

By Santhosh Babu

Campaigning for Saturdays Delhi assembly elections ended on Thursday. This time, due to nationwide protests and rallies related to the Citizenship (Amendment) Act, the polls can be crucial to study how voters respond to the campaigns.

In the 2015 film, Our Brand is Crisis, a fictionalised account of how political campaign experts influenced the 2002 Bolivian presidential elections, the oppositions political strategist says, You know, when Adlai Stevenson was running for president, a woman came up to him on a rally one night and said, Every thinking person will be voting for you. Stevenson said Ma'am, thats not enough. I need a majority.

In other words, the thinking people may not be enough to make a majority. Then who are the majority? If the majority is not using its thinking skills, what are these people using to choose whom to give their vote?

Let us look at the campaigns and strategies of the three political parties during the Delhi elections from a behavioural science perspective. To analyse the impact of the campaigns of BJP, Congress and Aam Aadmi Party (AAP), one needs to examine three parts of the human brain. These three parts are not, of course, independent entities and there is some overlap and a collective way of functioning.

1. The Reptilian Brain: Humans share this with birds and reptiles. This part of the brain is in control of our innate and automatic self-preserving behaviour patterns, which ensure our survival and that of our species. Instincts of feeding, fighting, feeling and reproduction are influenced and controlled by this brain. So, defending territory, flight and fight responses, and aggression are based in this part of the brain, sometimes called the unconscious brain.

BJP campaigns are usually designed more to appeal to this part of the brain. Protecting territory, aggression, self-preservation, and safety from perceived enemies become the most predominate messages in the campaign. BJP is not alone in this strategy. Donald Trumps presidential election campaigns leading up to his victory in January 2017 also focused on this part of the human brain. National security, safety from other religions and cultures not similar to ones own, and a stark either a friend or an enemy attitude appeal very well to a reptilian brain.

2. The Emotional Brain: While self-preservation and aggression in the reptilian brain can create powerful emotions, the centre of emotions resides in the mammalian brain that humans share with other mammals. For instance, While rationally people know smoking is injurious to health, the positive feelings we associate with smoking most often overcome our rational thoughts.

Many reptilian brain focus areas like self-preservation, fighting and reproduction are also related to strong emotional experiences. An easy way to differentiate them is to look at sex for lust or reproduction, and sex as an emotionally bonding activity. The first could be closer to the primitive reptilian brain; the second closer to the emotional one. The Congress campaign on TV has tried to create a positive emotion about Delhi, connecting it to the party.

3. The New Brain (Neocortex): This part of the brain is responsible for abstract and rational thought, foresight, hindsight, insight, reasoning, decision-making and logical problem-solving.

So, in an easy (although oversimplified) way, we could say the reptilian brain is our primitive, instinctive brain, the mammalian one is our emotional brain, and the neocortical one is our logical brain. AAPs claims about focus on health and education, and its appeal to votes based on the work the government and party have done is an appeal to the new brain.

In his 2011 book, Thinking, Fast and Slow, 2002 economics Nobel laureate Daniel Kahneman writes that fast thinking often relies on prior experiences to make decisions. Fast thinking relies on the limbic system -- the emotional part of the brain, and to the reptilian brain that works with stimulus and response.

On the other hand, slow thinking takes place in the neocortex, the rational part of the brain. Slow thinking is hard work and takes a lot of brain energy. But this process is what allows us to solve complex problems.

So, which part of the brain is likely to be most effective in Delhis election campaigns? The advertising fraternity will say that addressing the reptilian and emotional brain is most effective. As the quote from Our Brand is Crisis has it, in elections, every thinking person voting for you is not enough. You need a majority to win, something that BJP has been most aware in previous elections.

The writer is CEO OrgLens, a social network mapping company

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Delhi elections: Which campaign brain will win? - Economic Times

This Awesome Jacket Uses an LED Array to Display Huge Emoji

Ford has created a jacket for bicyclists that allows them to communicate with drivers using emoji displayed in LEDs on the rider's back.

Biker Jacket

Multinational automaker Ford has devised a clever way to decrease the chances of accidents between cyclists and drivers: a jacket that displays emoji in LEDs on its back.

The Emoji Jacket prototype, which Ford unveiled Thursday as part of its ongoing “Share The Road” campaign, has a large LED array on the back that can display one of six emoji at a time: ? ? ? ? ? ?

A cyclist uses a wireless remote attached to the handlebars of their bike to choose the emoji they want to display, the idea being that they would no longer need to remove their hands from the bike to communicate with others on the road.

Good Talk

So far, Ford has only created one of the jackets, and there’s nothing to indicate that the company plans to begin mass-producing them.

However, the prototype does demonstrate how a deceptively simple idea could actually save lives.

“[A]ll too often between drivers and cyclists, [communication] just comes down to the beeping of a horn or a rude gesture,” Emmanuel Lubrani, Ford of Europe’s senior manager, brand communications and content development, said in a blog post. “The Emoji Jacket uses a universally understood means of communication to show one way in which tensions could be eased — and we all learn to ‘Share The Road.'”

READ MORE: Ford’s biking jacket shows emoji to everyone behind you [Engadget]

More on bicycles: Lyft Suspends SF E-Bikes Because They’re Bursting Into Flames

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This Awesome Jacket Uses an LED Array to Display Huge Emoji

China to Round up Infected in “Mass Quarantine Camps”

The government of China has ordered officials in Wuhan to round up and quarantine any sick residents in makeshift shelter camps.

A senior official in the Chinese government has instructed authorities in Wuhan, the city where the ongoing coronavirus outbreak originated, to round up the sick and quarantine them in isolated hospitals and shelters.

The vice premier leading the government’s response to the 2019-nCoV epidemic, Sun Chunlan, has instructed Wuhan officials to go door to door, according to The New York Times. She told them to check residents’ temperatures and investigate anyone who came in contact with known patients.

“Set up a 24-hour duty system,” Sun said, according to the NYT. “During these wartime conditions, there must be no deserters, or they will be nailed to the pillar of historical shame forever.”

It’s an extreme, authoritarian move: rounding up and isolating thousands of residents in makeshift shelters that are being hastily assembled per the government’s order.

Some of the shelters, which are being assembled in sports arenas and other large facilities, opened up on Thursday.

Social media posts are already showing grim, cramped situations, the NYT reports. Doctors and medical supplies are reportedly in short supply.

It’s difficult to be optimistic that this roundup will improve conditions within the city, which has been under lockdown for weeks.

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China to Round up Infected in “Mass Quarantine Camps”

Human Trial Suggests CRISPR Could Be a Viable Cancer Treatment

Scientists just published the results of the United States first trial of CRISPR-edited cells in cancer patients — and they're very encouraging.

Scientists from the University of Pennsylvania just published the results of the first U.S. trial of CRISPR-edited cells in cancer patients — and they’re very encouraging.

In April 2019, UPenn confirmed that a team of its researchers had officially begun testing CRISPR-edited cells in humans.

For that trial, the scientists had removed immune cells from three patients with advanced, treatment-resistant cancers. They then used CRISPR-Cas9 to edit the cells in order to improve their ability to fight tumors before returning them to the patients’ bodies.

In November, the team shared the promising results of their CRISPR trial online, noting that the edited cells were still detectable in the patients’ bodies and hadn’t produced any negative side effects.

However, the study had yet to undergo the peer-review process at that point. That meant the results were still only tentative prior to the study’s publication in the journal Science on Thursday.

Because this was only a Phase 1 trial, the researchers’ focus was on the safety of the treatment — not on its efficacy.

But as CRISPR inventor Jennifer Doudna pointed out in a Perspectives essay published alongside the study, knowing that CRISPR-edited cells won’t harm cancer patients is the first step to using those cells to treat the disease.

“Until now, it has been unknown whether CRISPR-Cas9-edited T cells would be tolerated and thrive once reinfused into a human,” Doudna wrote, later adding that the UPenn team’s findings “represent an important advance in the therapeutic application of gene editing and highlight the potential to accelerate development of cell-based therapies.”

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Watch a Cybertruck Replace the DeLorean in “Back to the Future”

YouTuber Elon McFly has uploaded a perfect rendition of what would happen if the iconic DeLorean in

LOL GAS

“When this baby hits 88 miles per hour, you’re gonna see some serious shit.”

A YouTuber who calls themselves Elon McFly has uploaded a pixel-perfect vision of what would it would look like if the iconic DeLorean in the 1985 blockbuster “Back to the Future” was replaced by a Tesla Cybertruck.

In the clip, the Cybertruck can be seen accelerating to 88mph before traveling through time — leaving behind only two burning tire tracks and a bent license plate that reads “LOL GAS.”

Elon McFly

It’s a surprisingly competent fan remake that manages to fool the eye with impressive lighting and rendering. The truck is also exactly what you’d expect a converted time machine Cybertruck to look like, from the haphazard wiring on the exterior to the light-up buttons on the inside.

It’s not the Cybertruck’s first appearance in popular culture. Rapper Travis Scott heavily featured the pickup truck and its electric ATV companion in his December music video for the song “Gang Gang.”

READ MORE: Tesla Cybertruck blasts “Back to the Future” in amazing fan-remake [Teslarati]

More on the truck: Elon Musk Admits He Worried “Nobody Would Buy” Tesla’s Cybertruck

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Watch a Cybertruck Replace the DeLorean in “Back to the Future”

University Chancellor Predicts “Higher Forms of Life” on Europa

Monica Grady, a professor at Liverpool Hope University, claims that there is

Doctor Octopus

Monica Grady, the chancellor at Liverpool Hope University in the UK, says it’s likely there’s advanced alien life on Jupiter’s moon Europa, according to a recent statement.

“If there is something on Mars, it’s likely to be very small — bacteria,” she said. “But I think we’ve got a better chance of having slightly higher forms of life on Europa, perhaps similar to the intelligence of an octopus.”

Big Tentacle

Grady believes creatures could be living in glacial oceans underneath a hard shell of ice that’s up to 15 miles thick on Jupiter’s frigid moon.

Scientists have long suspected the existence of these deep subsurface oceans on Europa — and maybe even life. In fact, NASA announced in August that it’s completing the final designs for a Europa-bound spacecraft called Europa Clipper, which will look for signs of life.

Under the Sea

As far as the existence of other human-like aliens in our own solar system, Grady is not optimistic.

“I’m fairly certain we’re all there is at our level of intelligence in this planetary system,” she said. “And even if there are octopuses on Europa, that doesn’t give us a reason to destroy our planet.”

READ MORE: ‘Racing certainty’ there’s life on Europa and Mars, says leading UK space scientist [Liverpool Hope University]

More on Europa: Scientists Confirm Water Vapor Above the Surface of Europa

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University Chancellor Predicts “Higher Forms of Life” on Europa

Whistleblower Doctor Who Warned of Viral Outbreak Dies From It

After a mix of conflicitng reports, Li Wenliang, the Wuhan doctor who warned about the coronavirus outbreak in its earliest days, died early Friday morning.

Li Wenliang, the doctor from Wuhan, China who was one of the first to warn others about what was then an emerging coronavirus outbreak, died of the virus early on Friday morning.

Li was hospitalized in January with a bad case of 2019-nCoV. This week, reports emerged that he had died — an announcement that was immediately contested by conflicting reports from Chinese officials and Wuhan Central Hospital, which released a bizarre statement saying that doctors were still trying to resuscitate Li, who it claimed was not dead but actually in critical condition.

Now, the hospital has finally confirmed that he is in fact deceased.

“Our hospital’s ophthalmologist Li Wenliang was unfortunately infected with coronavirus during his work in the fight against the coronavirus epidemic,” reads a statement from Wuhan Central Hospital. “He died at 2:58 AM on Feb. 7 after attempts to resuscitate were unsuccessful.”

Li’s reputation as a whistleblower comes from warnings he shared about the disease that then spread on social media.

He was working in Wuhan when he warned his medical school alumni network about a potential outbreak. Li initially thought the coronavirus may have been SARS, an error that got him in trouble with the Chinese government.

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India’s Devious New Traffic Lights Stay Red When Drivers Honk

To stop a constant barrage of car honking noise, the Mumbai police installed horn noise detectors at traffic lights. The more noise, the longer the red.

The Punishing Signal

To stop a constant barrage of car honking, the Mumbai police in India have installed noise detectors at traffic lights, The New York Times reports. The more honking, the longer the light stays red.

Their evocative name for the system: “The Punishing Signal.”

Horn not okay, please!
Find out how the @MumbaiPolice hit the mute button on #Mumbai’s reckless honkers. #HonkResponsibly pic.twitter.com/BAGL4iXiPH

— Mumbai Police (@MumbaiPolice) January 31, 2020

Mute Button

The cops also installed cryptic signs on intersections with the new system that read “Honk More, Wait More.”

A tongue-in-cheek video uploaded by Mumbai police last week has gone viral with several million views.

“Maybe they think that by honking, they can make the signal turn green faster?” the narrator of the video says.

Traffic Attack

The devious devices work by measuring the decibels at a given intersection. As soon as it detects that cars are honking at 85 decibels or higher — about the equivalent of a freight train passing from 15 feet — the red light stays on longer.

“This is what we wanted to tell them: Honking or making noise doesn’t move the traffic,” Mumbai police spokesman Pranaya Ashok told the Times. “The traffic takes its own time to move, O.K.?”

READ MORE: Mumbai Police Play a Trick on Honking Drivers [The New York Times]

More on India: India Wants to Send This Legless Humanoid Robot Into Space

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India’s Devious New Traffic Lights Stay Red When Drivers Honk