Healthy Habits Backslide After Starting Statins, Antihypertensives – Medscape

Although a heart-healthy lifestyle is potent medicine in the management of cardiovascular risk, a large Finnish study finds that many but not all patients forgo healthy habits after starting a statin or antihypertensive medication.

Researchers studied 41,225 public-sector workers free of cardiovascular disease at baseline who completed at least two surveys in 4-year intervals from 2000 to 2013.

Results show that body mass index (BMI) ticked up among all participants, but the average increase was larger among those starting an antihypertensive or statin medication (adjusted difference, 0.19; 95% CI, 0.16- 0.22).

Participants who started medications were 82% more likely to become obese (adjusted odds ratio [OR], 1.82; 95% CI, 1.63- 2.03).

Medication initiators were also more likely to cut back on physical activity (adjusted difference, 0.09 METh/day) and were 8% more likely to become physically inactive (adjusted OR, 1.08; 95% CI, 1.01- 1.17), regardless of their baseline activity.

"My concern when I started this study was that people would think, 'now I don't need to worry about my lifestyle because the medication will do all the work for me.' Our study supports that idea," lead author MaaritJ. Korhonen, PhD, a senior researcher at the University of Turku in Finland, said in an interview.

The study is better than many that have been done before because it looks at lifestyle changes over time but, unfortunately, the results are not that surprising, Russell Luepker, MD, the Mayo Professor of Epidemiology and Community Health at the University of Minnesota in Minneapolis, told theheart.org| Medscape Cardiology.

"People who get started on medications for their increased cardiovascular risk may let other things slide some," he said. "We live in a pill culture."

The study was published today in the Journal of the American Heart Association.

Although the data provide more support for the belief that initiation of preventive medication is more likely to substitute for a healthy lifestyle than complement it, there were some positive signs.

Baseline smokers who initiated statin or antihypertensive therapy were 26% more likely to quit smoking than those who remained untreated (adjusted OR, 0.74; 95% CI, 0.64- 0.85).

Average weekly alcohol consumption went down more among medication initiators than noninitiators (1.85g/wk; 95% CI, 3.67 to 0.14), although the odds of heavy drinking were similar in the two groups, the authors report.

Korhonen struggled to explain why some healthy habits were adopted and others ignored. Although smoking cessation often results in weight gain, this did not explain the increased BMI finding. Smokers who took medications and quit gained more weight than smokers who quit but were untreated.

During the study period, an intensive national public health effort took place in Finland aimed at increasing awareness of diabetes mellitus and its risk factors, including the same lifestyle factors considered in the study.

"Finnish people with hypertension have also been given information on all these lifestyle changes, and still it looks like there's this divergence," Korhonen said. "So truly I don't have a clear explanation for that."

Although frustrating for physicians, the divergence is "probably not a wash," Luepker said. "I think in the large trials of statins, some of this happens, but the drugs are more powerful."

"What this reinforces to me is that we're good at prescribing things but not very good at making people successful in changing their health behaviors, and these things are additive to the drugs."

That said, Luepker observed that 15-minute physician appointments do not lend themselves to detailed lifestyle discussions and that more support staff and insurance reimbursement are needed to enhance lifestyle-modification counseling.

It is not known whether study participants were given information or counseled on healthy lifestyles but, in general, there is a recommendation that patients see a nurse regularly, "maybe once a year," after being prescribed statins or antihypertensive medications, Korhonen said.

"I think with what has been just stated in the new US [primary prevention] guidelines, which are in line with the European ones, that some new approaches have to be found and used cognitive-behavioral strategies and also this multidisciplinary approach," she added. "We need new ways to get the message across and support the patients."

That message also needs to take into account the patient's health literacy, Nieca Goldberg, MD, medical director of the NYU Women's Heart Program, New York City, told theheart.org| Medscape Cardiology.

"When we speak to patients, we need to figure out what that individual understands," she said. "Not everyone is the same, and every patient you see has a different level of health literacy. So we really need to tailor our messaging to the individual patient to try to figure out what it is that will motivate that patient."

When prescribing statins, Goldberg said she emphasizes the importance of diet and exercise in further reducing cholesterol and cardiovascular risk, but that medication dosage can also be a powerful motivator for some.

"I can only share what I say to my patients and I get relatively good compliance: I tell them that doing these lifestyle changes will help us keep the same dose of medicine," she said. "That seems to be helpful because people have this idea in their mind that getting a higher dosage is a bad thing."

The researchers used pharmacy-claims data to determine medication use but did not have information on participants' diet, blood pressure, or cholesterol levels. Other limitations are the generalizability of the results outside the relatively homogenous sample of mostly white, female workers (84%; mean age, 52 years), Korhonen said.

She noted that the results are in line with previous evidence that comes mostly from cross-sectional studies looking only at statins or only at antihypertensive medications, but that this is probably the largest study conducted on this topic to date that looked at both medications and is also longitudinal.

The main results did not change appreciably in sensitivity and subgroup analyses, although these analyses showed that BMI increases were more pronounced among those taking medications aged 40 to 49 years.

Participants who already had three or four unhealthy behaviors at baseline (n= 1231) were also at particular risk. Those taking preventive medications had greater increases in BMI and decreases in METh/day than noninitiators, with no significant difference in change in average alcohol consumption or in the odds of current smoking.

"To the individuals who start these medications, I would tell them they should make an effort to continue to manage their weight, be physically active, keep alcohol consumption in moderation, and quit smoking because all these changes help them decrease their cardiovascular risk and also live a healthier life overall," Korhonen said.

The study was supported by the Academy of Finland. Korhonen received grant support from the Hospital District of Southwest Finland. Luepker and Goldberg reported having no conflicts of interest.

J Am Heart Assoc. Published online February5, 2020. Full text

Follow Patrice Wendling on Twitter: @pwendl. For more from theheart.org| Medscape Cardiology, join us on Twitter and Facebook.

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Qatar- QBRI encourages residents to stay active to improve health – MENAFN.COM

(MENAFN - The Peninsula) National Sport Day was first held in Qatar in 2012 and it provides an excellent opportunity to unite the country's residents to take part in fun sporting activities.

But there is another essential aspect to National Sport Day. It is the timely chance to promote healthy living and raise awareness of why an active and sensible lifestyle is important in keeping diseases at bay.

Qatar Biomedical Research Institute (QBRI), part of Hamad Bin Khalifa University, was launched in the same year as the first National Sport Day. The similarity does not end there as QBRI also actively encourages a healthy lifestyle.

It does so to improve and transform healthcare through innovation in prevention, diagnosis and treatment of diseases affecting the Qatari population and the region.

QBRI has three centers of excellence - the Cancer Research Center, Diabetes Research Center and Neurological Disorders Research Center - and all three encourage staying active and eating well to reduce the risk of disease.

The Cancer Research Center focuses on understanding the cellular and molecular basis of cancer initiation and progression with a focus on breast cancer, which is the most common type of the disease among females globally.

Dr. Eyad Elkord, a Principal Investigator at the Cancer Research Center, said: 'Maintaining a healthy lifestyle lowers the risk of cancer onset and different studies showed that significant numbers of cancer deaths are due to lifestyle-related risk factors.

Exercise controls tumor growth by mobilising immune cells within the body and releasing some factors from muscles with anti-tumor properties.

'Moreover, regular exercise and healthy eating habits maintain stability within the body, known as hemostasis, and could help to prevent cancer initiation. Aerobic and cardiovascular exercises, coupled with a balanced and nutrient-rich diet, are highly recommended for healthy individuals as well as cancer patients undergoing treatment.

The Diabetes Research Center serves as a catalyst to promote innovative research on both Type 1 and Type 2 diabetes and related metabolic disorders. Its primary goal is to gain fundamental knowledge and enhance the understanding of social, molecular and genetic causes of the disease.

Dr. Paul Thornalley, Director of the Diabetes Research Center, said: 'Exercise is good for the health of diabetics, whether they have Type 1 or Type 2 diabetes. It helps to improve your health and also decrease the risk of complications of diabetes.

Patients with Type 1 diabetes should check with their physician before taking on a new exercise routine to plan how to best manage their blood glucose and insulin injections accordingly.

'For Type 2 diabetes, which is often associated with being overweight and obese, exercise is a good way to control and improve body weight, the body's responsiveness to insulin and blood glucose control. Particularly, in recently-diagnosed Type 2 diabetes, exercise may help along with a decreased calorie intake to reverse the development of diabetes.

'In overweight and obese people, doing more exercise and eating in moderation to lose weight will help prevent developing Type 2 diabetes. It is recommended to do about two-and-a-half hours' exercise per week, said Dr. Thornalley.

The Neurological Disorders Research Center focuses on investigating neural conditions of increasing prevalence in Qatar and the region. These ailments are wide-ranging and include autism spectrum disorder, intellectual disability, epilepsy, Alzheimer's disease and Parkinson's disease.

Dr. Yongsoo Park, a scientist at the Neurological Disorders Research Center, said: 'Neurological disorders result from problems of the central and peripheral nervous system but physical exercises and activities can make our nervous system active and healthy, and therefore reduce the risk of neurological disorders.

'Physical exercise leads to and increases neurogenesis (creating new neurons), neuroplasticity (improving neural networks) and synaptic transmission (enhancing neurotransmitter release and improving brain function) so the neurological benefits of exercise is significant.

For elderly people, yoga, walking, running and swimming are highly recommended, but a healthy diet, good sleep and staying socially engaged with friends and family is also beneficial.

'We should be doing everything we can to lead a healthy lifestyle. That means eating well, exercising, avoiding harmful things, getting enough sleep and avoiding stress, said Dr. Park.

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Binge All 6 EpisodesSecrets to a Healthier, Happier You in 2020! – Life & Style Weekly

It may already be February, but there is still plenty of time to live your best life in 2020 with the help of the Secrets to a Healthier, Happier You in 2020 podcast.

After just one week, the stat is that 77 percent of resolution markers are still on track, RxSavers medical expert Dr. Holly Phillips tells Us Weeklys Christina Garibaldi during episode 1 about New Years resolutions. So youve already lost about a quarter of people by the very first week in January. And after six months, 60 percent have dropped out.

Over the course of six episodes, the health experts provide advice for maintaining your mental health, the importance of heart health, exercise tips and more. Scroll through to binge all six episodes:

Episode 1: New Years Resolutions

Whether youre quitting smoking, starting a new diet and exercise plan or just trying to maintain an overall healthy lifestyle, this episode will unveil the tips you need to know when it comes to keeping your New Years resolutions.

Episode 2: Mental Health

It seems that we dont treat people with mental illness with the same compassion as we treat people who have certain physical illnesses, Phillips says in the second episode, which emphasizes that mental health should be treated with the same care as physical health.

Episode 3: Healthy Immune System

On episode 3, learn tips to avoid catching the common cold. If youd like to boost your immune system, make your plate as colorful as possible, Phillips says. Brightly colored fruits and vegetables If its really bright, you know you have the antioxidants you need.

Episode 4: Sleep Secrets

Listen to episode 4 to uncover how rest plays a crucial factor in your energy throughout the day. Make sure that your bedroom is conducive to sleep. It needs to be dark, quiet, and it needs to be cool, Phillips reveals. The best temperature is somewhere between 60 and a high of 72 degrees.

Episode 5: Stay Fit Safely

Episode 5 tackles expert tips about how to protect whats inside your body while working out. When we think about fitness or about hitting the gym, a lot of the focus is on weight loss or maintaining our weight or how we look. But its absolutely critical for the health of our bones, muscles and joints to stay active, the health expert says. Any exercise that puts your body against gravity can help muscles get stronger and better protect your joints.

Episode 6: Heart Health

On the final episode of The Secrets to a Healthier, Happier You in 2020 podcast, Garibaldi and Phillips reveal the importance of heart health and how it affects every aspect of your life. The heart is the center of the body. Its the most important muscle, Phillips explains. It pumps blood and oxygen to all of our organs. We literally cant live without it.

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Commit to Good Health During February and American Heart Month – Patch.com

February is American Heart Month, and each year health care professionals across the country take time to raise awareness about heart disease. It's the perfect opportunity to think about heart health, and the choices individuals can make that will lead to a lifetime of improved health.

Heart disease affects people in different ways and living a healthier lifestyle and knowing the signs are the best weapons against it. In 2016, cardiovascular disease accounted for 1 in 3 deaths, according to the American Heart Association, and coronary heart disease remains the No. 1 cause of death in the United States.

In the spirit of the month, Dr. Cindy Codispoti, DO, fellowship trained in cardiovascular disease, part of Atlantic Medical Group Cardiology at Hackettstown and on-staff at Hackettstown and Morristown Medical Centers, discusses heart disease and how to take necessary precautions against it.

Q: Are there different types of heart disease?A: Yes, there are numerous types of heart disease. These include, but are not limited to, coronary artery disease (typically blockages in the heart arteries), heart failure, abnormalities of the heart valves, arrhythmias (abnormal heart rhythms) and congenital heart disease (abnormalities of the heart structure one is born with).

Q: Are men and women affected by heart disease in the same way?

A: Heart disease does not affect all people in the same way, and there are certainly gender differences as well. Some of these differences include the timing of presentation with heart disease. For example, men are at higher risk for developing coronary heart disease earlier in life than women. However, there is a higher incidence of women developing coronary heart disease later in life. Also, symptoms of coronary artery disease may vary more in women than in men. Women are less likely to have classic symptoms of chest pain or pressure beneath the sternum radiating to the jaw or left arm.

Women may be more prone to heart failure than men, especially as it relates to coronary artery disease. Additionally, women are more prone to a few specific diagnoses, such as coronary artery spasm, which can cause chest pain or even heart attack. Women also are more likely to develop an entity called 'broken heart syndrome,' which is acute heart failure that presents like a heart attack. This is typically triggered by a significant life stressor, such as the death of a loved one. We see this more in females than males.

In addition to gender differences, we are increasingly aware that ethnic differences affect risk of heart disease as well, and these must be strongly considered.

Q: Is there any way to tell between bad indigestion and a heart attack?A: This is not so clear, unfortunately. Certainly, if symptoms are directly related to eating and easily relieved with antacids, the symptoms may be due to acid reflux. However, if patients with risk factors for heart artery disease (diabetes, high blood pressure, high cholesterol, cigarette smoking, family history, and older than 45 in males and 55 in females) are experiencing these symptoms, they should seek expert advice from their doctors.

Q: Do you have any advice for women who are concerned with heart health?A: Yes. Take ownership of your health. Choose a clean and healthy lifestyle to protect your heart. Our world is full of stressors. Find healthy outlets for that stress and emphasize daily exercise. Prioritize heart health. As natural caregivers, this can be easy to brush off, making everyone else a priority. Lastly, know that there are experienced cardiologists in the community who are happy to serve you if you do have problems with your heart or risk factors for heart disease.

Visit atlanticmedicalgroup.org for more information.

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Heart attack symptoms can be more than chest pain – Home – WSFX

February is heart health awareness month, but a shocking number of American adults dont know the signs of a heart attack. In Dec. 2019 study, 47 percent of respondents didnt recognize some of the symptoms, and 6 percent were not familiar with any symptoms at all.

And with nearly half of the countrys adult population suffering from a form of cardiovascular disease, researchers say its imperative for Americans to be educated about the warning signs. Dr. Matthew Tomey, a cardiologist at Mount Sinai St. Lukes, told Fox News that not all patients may experience the same symptoms, which is why its important to recognize each one.

THESE 6 JOBS ARE LINKED TO POOR HEART HEALTH FOR WOMEN

Chest pain is the classic symptom of a heart attack, but it is important to appreciate that different people can experience chest pain in different ways, Tomey said. Chest discomfort associated with a heart attack, also known as acute myocardial infarction, can be felt as pressure, squeezing, heaviness, tightness or even like indigestion. Some people having a heart attack do not feel pain but rather shortness of breath.

And while patients may be quick to dismiss the above symptoms as a product of something else, Tomey warned that certain accompanying features such as sweating, nausea and vomiting or radiation to the arms increase the likelihood that the discomfort are signs of an impending heart attack.

If you think you are having a heart attack, seek immediate medical attention, Tomey said. Key treatments for heart attack, including therapies to restore blood flow to the heart, are most effective when delivered early.

BURNOUT LINKED TO POTENTIALLY LETHAL HEART CONDITION

Tomey also advised against trying to go it alone and to call 911 to get help from paramedics.

Its also important, Tomey said, to recognize that everyone is at risk of a heart attack, but there are certain factors that can increase that risk such as age, gender, high cholesterol, smokingand high blood pressure. Obesity, sedentary lifestyle and diabetes mellitus are also considered risk factors.

Individuals with a family history of a heart attack may also be at increased risk, although it is important to recognize that factors beyond genetics may have affected family members risk for heart attack, Tomey said. For some individuals, additional testing can be helpful to elucidate risk.

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He also said that each of us has the power to reduce risk of heart attack, and it begins with a simple self-assessment to evaluate blood pressure, cholesterol levels, exercise habits, weight, diet and lifestyle factors.

Each of these represents a potentially modifiable risk factor for cardiovascular disease, he said. For individuals with a family history of heart attack, it is encouraging to learn that family history need not be destiny: adherence to a healthy lifestyle is associated with a substantial reduction in risk.

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Outlook for heart attack survivors also depends on adjusting lifestyle factors and care while under the guidance of a cardiologist, Tomey said.

Today, we are fortunate to have an array of tested therapies to help survivors of heart attack live longer, healthier lives, he said.

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Heart attack symptoms can be more than chest pain - Home - WSFX

How to live longer: The best diet proven to increase life expectancy and ward off cancer – Express

The age-old secret to a longer and healthier life really comes down to ones lifestyle which includes regular exercise, limiting alcohol intake, not smoking and eating a healthy balanced diet. Good nutrition is key to leading a healthy lifestyle. No major surprise really that those who follow healthy diets tend to lead longer and healthier lives. However with the bombardment of the latest and greatest diets its easy for one to get bogged down with information overload. According to leading health experts and scientists, there is a diet that proves tops when it comes to living long and healthy.

According to a new study published in The Journal of Nutrition, veganism may be the secret to a longer life.

The study, which looked how various diets impact biomarkers, found that vegans have the most antioxidants in their bodies.

This is largely due to their higher intake of fruit and vegetables.

In fact, vegans have substantially lower death rates than meat-eaters. For several decades, research has consistently found that a vegetarian diet, which is mainly made up of vegetables, fruits, nuts, legumes and wholegrain, can reduce risk of major diseases and help you live longer.

READ MORE: Stephanie Davis health: The pain took over my mind, body and soul Stars difficult time

A team of researchers at Loma Linda University has shown vegetarian men live for an average of 10 years longer than non-vegetarian men.

For women, being vegetarian added an extra six years to their lives, helping them reach 85 years on average.

The Loma Linda team were also behind the ground-breaking Adventist Health Study-1 regarding life expectancy.

This study was considered the gold standard in the world of nutrition because it was a comprehensive, long-term study that involved a large number of people.

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For 14 years, Loma Linda researchers tracked diets, lifestyle and diseases among 34,000 participants who dont smoke or drink.

The study found that there were five key habits that could help add years to ones life.

They were eating a plant-based diet, eating a handful of nuts regularly, being active, not smoking and being a healthy weight.

The research found on average these lifestyle factors could each provide an extra two to three years to ones life.

A growing number of similar studies have linked plant-based diets to many health benefits, including lower risk of cancers and heart disease.

Sticking to an overall plant-based diet or a diet that includes more plant foods than animal foods could be associated with a 16 percent lower risk of cardiovascular disease and up to 25 percent lower risk of early death.

Assistant professor at the John Hopkins Bloomberg School of Public Health, Casey Rebholz said: Plant-based diets emphasise higher intakes of plant foods and lower intakes of animal foods.

Animal foods include meat, eggs, dairy and fish or seafood.

In our studies, we did not define plant-based diets on the basis of complete exclusion of animal foods from the diet but rather ranked individuals according to their relative frequency of intake of the foods.

Dr Michelle McMacken, director of the plant-based lifestyle medicine program at NYC health + Hospitals added: The higher the proportion of plant foods in the diet, the lower the risk of cancers and cardiovascular events and death from any cause.

"Reason for this is, first this diet is higher in beneficial nutrients such as fibre, plant fats, potassium and antioxidants and lower in potentially harmful nutrients such as animal-based iron, animal fats and nitrite preservatives.

"Second, plant-based diets are also linked to healthier body weights, lower inflammation, lower risk of type 2 diabetes, better blood pressure and blood vessel function, and beneficial gut bacterial metabolites. All of these factors translate in lower risk of diseases.

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3 healthy habits that can help you live 10 years longer – Firstpost

Healthy habits such as regular exercise and a healthy diet can add up to 10 years of disease-free life, according to a major study published in theBritish Medical Journal (BMJ). The study, which examined health data of over 110,000 participants between 1980-2014, found that some long-term healthy habits can have a meaningful impact on our lives.

Representational image.Image by StockSnap from Pixabay

The habits included not smoking, exercising for at least 30 minutes a day, drinking moderately, following a healthy diet and maintaining a BMI between 18 and 25. The study found that those who consistently followed these habits had a lower risk of cardiovascular disease, cancer and type 2 diabetes.

According to the data, women over 50 with healthy lifestyle habits were likely to live for 41 more years, whereas women who didnt have any of these healthy habits were likely to live for 31 more years. Similarly, with men, those with healthy habits would likely live another 39 years as opposed to 31 years for those who had no healthy habits. The data was based on questionnaires conducted every two years and corroborated by the health records of the participants.

The study also suggested that those with healthy habits would also survive longer after contracting chronic diseases. Men who smoked a lot and those with a BMI of over 30 performed the poorest.

The disparities the study highlights are substantial. Encouragingly, since the behaviours are modifiable, there are many steps we can take to make our lifestyle healthier and lives longer and happier. Here are some tips based on the findings of the study:

1. Eat a balanced diet: A balanced diet includes a range of food groups in the right quantity so it satisfies the dietary requirements of essential minerals and vitamins. Here are some recommendations.

2. Get exercising: 150 minutes of moderate aerobic exercise per week is important. This comes down to 30 minutes spaced between 5 days. What is moderate aerobic exercise? It is a workout that will raise your heart rate and breathing and make you feel warmer. Activities like brisk walking, hiking, cycling, dancing and even pushing a lawnmower can be a good idea.

3. Limit alcohol intake and quit smoking: We have the tendency to forget that alcohol contains calories as well. Drinking excessively will have an impact on your waistline. Smoking is associated with terrible long-term health outcomes and quitting is in the best interests of you and your loved ones. Nicotine replacement therapies along with counselling have been showing encouraging results.

Working every day on your health will have a big impact on your overall wellbeing. Now is as good a time as any to invest in yourself!

For more information, read our article on aBalanced Diet.

Health articles in Firstpost are written by myUpchar.com, Indias first and biggest resource for verified medical information. At myUpchar, researchers and journalists work with doctors to bring you information on all things health.

Updated Date: Feb 10, 2020 18:29:44 IST

Tags : Diet Tips, Exercise For Long Life, Healthy Habits, Life Span, Longevity, NewsTracker

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Four scientifically proven ways teen humans and adolescent animals are similar – The Irish News

EXASPERATED parents struggling with their teen's unfathomable behaviour may wonder if their adolescent is alone in acting so erratically. The answer, say researchers, is that not only do all human teenagers share similar characteristics, but their typical adolescent behaviour is reflected throughout the animal kingdom in creatures as small as insects to as large as whales.

Now the remarkable way human adolescent behaviour is mirrored in animals has been recorded in the new book Wildhood, written after years of research and travel by Harvard University evolutionary biologist Professor Barbara Natterson-Horowitz and science journalist Kathryn Bowers.

The pair studied the four universal challenges every adolescent of every species faces on the journey to adulthood: safety, status, sex, and survival. Here are four of the traits human and animal adolescents share:

1. Risk-taking:

Human teens aren't the only ones who take more risks and underestimate danger. The 'problematic' teenage brain specifically the late maturation of the prefrontal cortex which by adulthood is able to contain impulses is often used to explain higher adolescent rates of accidents, injuries and worse.

Strikingly similar brain biology during adolescence in other species pushes young wolves, possums, bears, and birds to take the risks needed to leave their dens, burrows and nests.

But this comes at a cost. Adolescent animals are disproportionately road-killed. Adolescent whales are more likely to be struck by shipping-lane traffic. And lacking experience recognising and evading predators on their own, adolescent animals have some of the highest rates of becoming prey.

In several species, adolescent animals exhibit behaviours which look risky but are actually adaptations to help them stay safer in the long run. Adolescent stickleback fish, bats, Thomson gazelles, and meerkats sometimes approach their predators instead of fleeing from them. This behaviour, called 'predator inspection', is at times dangerous, but the experience is crucial. The key is finding a way to gain experience while staying safe.

2. Social status:

Popularity, Instagram followers, 'likes' today's teenagers seem obsessed with status, sometimes acting as if it were a matter of life or death. But they aren't alone. For animal species who live in groups, status is a matter of life or death. In animal hierarchies, high status individuals eat more, live in safer places and reproduce more. They even have stronger immune systems and get better sleep.

Animal brains have evolved to signal when status is gained or lost. Like the physical pleasure which rewards animals for actions which increase survival and reproduction eating and having sex 'status pleasure' rewards animals when they rise up the ladder. The building blocks of the emotional centres in the human brain can be found in the brain status networks in fish, reptiles, birds and other mammals.

Status is one of the most powerful forces in the lives of adolescents across the animal kingdom.

3. Romance:

After young humans go through puberty, their bodies are physically capable of creating babies. However, they are many years away from being ready for parenthood. Remarkably, when wild animals go through puberty many will not have sex for years. In some cases, they must learn complex courtship steps, songs, and sequences before they breed.

Across the animal kingdom, music seems to have a powerful romantic impact. Canary and dove songs performed just right can induce ovulation in females. But it takes a lot of practice. Humpback whale adolescent males are invited to join choruses of males who loudly croon complex music that draws females to them. In the beginning, the adolescent males don't sing properly. With years of experience and practice, these whales become more powerful singers.

The songs and sequences of animal courtship are a complex language that takes time and practice to learn properly. Studies of the sexual lives of young wild animals confirm a species-spanning reality: sex is easy, courtship is hard.

4. Self-reliance:

Before they leave home, adolescent wolves go to 'finishing school', a term wolf biologists use to describe the adult hunts they're invited to join.

Leaving home is dangerous for young birds and mammals. While predators are a significant threat, finding enough food is challenging for animals on their own for the first time. In many species, parents provide preparation cheetah mothers disable gazelles and meerkat adults pull out scorpion stingers as practice prey for young hunters-in-training. But some learning can only happen when a young animal is hungry literally a do-or-die situation.

Across the animal kingdom and as in humans, self-sufficiency doesn't happen automatically. Preparation, practice, and hunger transform dependent young animals into self-reliant adults.

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Four scientifically proven ways teen humans and adolescent animals are similar - The Irish News

Key gene in making eggs and sperm discovered – BioNews

10 February 2020

Researchers from Kumamoto University in Japan have revealed a potential genetic cause for infertility in a new study published in Developmental Cell.

The work, carried out in mice, reports the identification of a new gene, which appears to regulate the process of meiosis, a specialised form of cell division that occurs in the ovaries and testes, leading to the generation of gametes (eggs and sperm).Most cells in the body replicate through a process of cell division called mitosis whereby a single cell doubles its genetic information and then divides equally to create two copies of the original cell. Meiosis takes this process a step further, proceeding to a second cell division, resulting in the generation of four cells that contain half the genetic material, so that upon fertilisation the new cell has one full set of chromosomes.

In the current study the team used a mouse model to identify the gene meiosin, which appears to drive meiosis. When inactivated the researchers observed a reduced or abnormal production of germ cells in both sexes.

The scientists also observed that meiosin is only expressed at certain times in the testis and ovary, when the switch from mitosis to meiosis is taking place, which makes it unique in comparison to other genes previously thought to regulate the process.

'Our work shows that the meiosin gene is the switch that turns on meiosis, the special type of cell division that creates eggs and sperm,' said Dr Kei-Ichiro Ishiguro lead author of the study.

When investigating further, the researchers revealed that meiosin itself switches on hundreds of other genes, many of which currently have unknown functions.

'We were quite surprised to find so many genes with undefined functions lying dormant in this study. We have high expectations that the processes involved in germ cell formation will be greatly clarified as the role each of these genes plays is discovered,' added Dr Ishiguro.

While meiosin is known to exist in humans, further work will be required to determine the exact role in human fertility.

The improper division of genetic material as a result of abnormal meiosis can result in miscarriages or chromosomal disorders. Although the research is at an early stage,the authors hope that the study will lead to a greater understanding of these issues.

'If it eventually becomes possible to control meiosis, the benefits would be far-reaching for reproductive medicine, agricultural production, and even assisting rare species reproduction,' Dr Ishiguro concluded.

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Key gene in making eggs and sperm discovered - BioNews

What Does Demography Reveal About Immigration Into West Bengal? – The Wire

The national debate for or against National Register of Citizens (NRC) and Citizenship (Amendment) Act (CAA) rages on. From tea stalls to shopping malls, from offices to social network, from primetime television to the protests on the street the discussion is everywhere. At the core of this debate is the fast-held belief that millions of immigrants from neighbouring Bangladesh have illegally entered West Bengal, Assam and Tripura, radically altering the state demographics. A fraction of Indian society passionately believes this is indeed the case and blame the illegal immigrants pampered for vote-bank politics for several socio-economic problems of India and these states specifically. Another major set of Indians the ones who are not so strongly against people of other religions and countries also believe that substantial immigration has taken place. Although this is a post-truth era dominated by alternative facts, it is desirable that people from all sides of the political spectrum have a look at hard evidence.

Immigration from Bangladesh in recent years

The laymans knowledge about millions of illegal immigrants is mostly based on anecdotal evidence and hearsay like it is known.., that vegetable vendor is from and in the border areas. Beliefs and opinions, especially when not substantiated by facts, are hard to change. However, an objective way to understand the subject is to do a testing of hypothesis i.e. you make a hypothesis and then, based on data collection and analysis, you conclude whether the hypothesis is correct or not.

So, in the case of West Bengal, the hypothesis is: If there has been a massive immigration of Bangladeshis (Muslims/Hindus) into the state in recent decades (and they were allotted ration cards, voter cards), that should skyrocket the states population number and substantially deviate its trend from the rest of the country. Do the numbers present in the census and surveys like NFHS agree with this?

If we look at the census data of 1981, 1991, 2001, and 2011 (graph 1 and table 1), the immediate conclusions are: the growth rate of WBs population has distinctly been less than the national average since the 1990s; this decrease is true not only for the whole population, but also for both Hindu and Muslim communities of over the past 2-3 census (Graph 1).

The decadal growth rates for WBs Hindus has been 21.1% in (1981-91); 14.2% in (1991-2001); and 10.8 % in (2001-2011). The corresponding values for WBs Muslims are 36.9% in (1981-91); 25.9% in (1991-2001); and 21.8 % in (2001-2011).

Graph 1 Population growth rates for 1991-2001 and 2001-2011 in India and WB

(Source: 1991, 2001, and 2011 Census; The table on the right showing the numerical values.)

In other words, the two major religious communities of WB are contributing less to the population of India compared to several other states, at least since 1991 for Hindus and since 2001 for Muslims. The states growth rate is less than the national average. This punctures the myth that West Bengal is bursting with a much larger-than-expected population because of Bangladeshi immigrants.

WBs border districts and illegal immigrants

It could be argued that a closer look into the border-districts of WB will show big changes in Hindu-Muslim demographics, as that is where the immigrants have entered. However, no such trend is visible from the census data of these districts. In concurrence with the lucid explanations by professors Subhanil Chaudhury and Saswata Ghosh, the population numbers clearly show that:

i) the 2001-2011 growth rates of almost all districts of WB has decreased compared to the previous decade (Graph 2),

ii) this holds true for Hindus and Muslims (Graphs 3A, 3B).

iii) there is no consistent trend in the border districts that can be explained by massive immigration.

Graph 2: Population growth rates for 1991-2001 and 2001-2011 in districts of WB

(Source:1991, 2001, and 2011 census; Dinajpur was divided into two separate districts, Uttar and Dakshin, in 1992 and so was Midnapore into East and West in 2002. Hence, i) the data of whole Dinajpur was plotted for both Uttar and Dakshin at 1991-2001, and ii) the data of whole Midnapore was plotted for both East and West at 1991-2001 and 2001-2011.)

Graphs 3: Population growth rates for Hindus (A) and Muslims (B) for 1991-2001 and 2001-2011 in districts of WB

(Source: same as in Graph 2)

The growth rate is higher than the state average in three districts which have a significant border with Bangladesh (North Dinajpur, Malda and Murshidabad). But this is less than the state-average in four other border districts (South Dinajpur, Nadia, Cooch Behar, and North 24 Parganas). Among the inward districts, Purulia, Medinipur and Birbhum have higher than average growth rates while Hooghly and Bardhaman have a slower population growth rate.

The striking thing is that the two communities parallel each other: Wherever the rate of growth of Hindus is high, it is high for Muslims; wherever it is less for Hindus, it is less for Muslims (table 2). In other words, there is no high Hindu growth rate, no high Muslim growth rate and no high-along-the-border growth rate. The census the major data source available for such studies just does not show any massive immigration into West Bengal.

Table 2:Growth rates of Hindus and Muslims parallel each other in districts of WB.

(Source: based on an article by S. Chaudhury and S. Ghosh, Anandabazar Patrika, Sept 10, 2015; The values were obtained by subtracting the state average of the community from the value for the district. WB state average (2011-2001) for Hindus is 10.81% and for Muslims is 21.81%.)

What drives the steady decrease of population growth rates for WB?

Briefly, it is increased levels of literacy, especially female literacy and (consequent) women empowerment. These are factors that have been globally recognized as prime drivers that cause a decline in the total fertility rate (TFR, number of children a woman bears) and this state is no exception. The TFR for WB(1.7/1.8 per children per woman) is among the lowest in the country and this applies to both the communities. Graph 4A compares TFR for the states Hindus and Muslims with the corresponding scenario from Kerala, one of the leading states in this regard and UP, one of the lagging states.

Furthermore, demographers (Ghosh, 2018; Haq and Patil, 2016) have noted that the gap between Hindu and Muslim fertility rates has reduced by more than one child (or very close to that) for states like WB, Assam and Kerala. In the case of WB, Hindus have reached replacement levels (<= 2.1 children per woman) in 18 out of the 19 districts, while Muslims follow that trend in 12 districts (Graph 4B). Evidently, the fertility rates of Bengals two major religious communities are converging something the policymakers and the people should both be happy about.

Graph 4A: Comparison of Total Fertility Rates (TFR) for Hindus and Muslims

(Source: TFR data from NHFS-4 for India, Kerala, Uttar Pradesh, and WB)

Graph 4B: TFR for Hindus and Muslims in districts of WB

(Source: Ghosh, S. (2018) Ind. J. Human Dev. 12, 37-51)

In this context, it is noteworthy that the 4th National Family Health Survey (NFHS-4, 2015-16) for WB had explained, The greatest differentials in fertility is by schooling. At current fertility rates, women with no schooling will have 1.2 children more than women with 12 or more years of schooling (a TFR of 2.5, compared with 1.3).

Truly, the higher the literacy rate of a WB district, the lower its population growth rate, and the higher the percentage of population below poverty line (BPL) the faster its population is growing (graph 6). These data also explain the higher growth rates and TFR of WBs Muslims compared to the states Hindus. Around 80% of WBs Muslims are among the economically most backward, and around 17% of Muslim families are still illiterate.

Graph 5: Correlation of Literacy (left) or Poverty (right)with Growth rate in WB districts(Source:2011 Census and 2006 Sachar Committee report)

Are the neighbouring regions of Bangladesh overpopulated?

No. Rather, the population growth rates and TFRs of Khulna, Rajsahi and Rangpur the three Bangladesh divisions flanking WB are among the lowest in the country (Graph 6). This is also in sync with the well-known fact that Bangladesh has been managing its population growth quite constructively and, in fact, its growth rate is less than Indias. And, in the absence of a bulging population, the reasons for immigration into WB are further reduced.

Map of West Bengal and Bangladesh (source: dmaps)

Graph 6:Population growth rates for 1991-2001 and 2001-2011 in divisions of Bangladesh(Source: BBS; note: Khulna, Rajsahi and Rangpur share border with WB)

What if the undocumented immigrants do not have voter, ration and Aadhaar cards?

That is WhatsApp legend. Neither does any peer-reviewed data indicate that, nor would it make much sense to allow millions to come in for vote bank and yet not give them voter cards. In contrast, the 2019 report of the UN Department of Economic and Social Affairs (DESA) pegs immigrants who were born abroad but now resident in India at 5.1 million at present. That is distinctly less than the 6.4 million in 2000 and 7.6 million in 1990. As for migrants from Bangladesh, their number has reduced from 4.37 million in 1990 to 3.1 million in 2019, and obviously, 3 million in 1.2 billion is chump change! The census drop-in report explains, This is due to substantial decline in the number of recent migration and death of earlier migrants due to old age. Immigration certainly is not Indias (or West Bengals) pressing problem. [Please note, these values are not migration happening every year, rather total number of migrant residents].

Does that mean emigration from Bangladesh has stopped? Not really, although a detailed understanding is beyond the scope of this article. However, the recent data does indicate that many more Bangladeshis are moving to other countries than to India. For eg, UN-DESA estimates that, in 2000, there were 1.49 lakh and 97,000 Bangladeshi immigrants in the UK and USA respectively. In 2019, the corresponding numbers have increased to 2.4 lakhs and 2.45 lakhs respectively. In Saudi Arabia, there were around 5 lakh Bangladeshis in 2000; today they are more than 1.2 million. Indians are moving too; at around 17.5 million in 2019, the largest number of international immigrants are from India.

Graph 7:Migrants from neighbouring countries resident in India

(Source: UN)

Muslims have multiple wives, so they have more children: Really?

A popular belief (the infamous hum paanch, humare pachchis) is that most Muslim men have 3-4 wives and this increases their number of children. However, a simple recollection of high school knowledge should be enough to dispel this myth. Briefly, human populations invariably have a natural gender ratio of 1:1 because of the way human reproduction works. The sex of a human child is determined by the fathers sperm male if the sperm had a Y chromosome and female if it carried an X chromosome. Spermatogenesis the physiological process that produces sperms in the testes produces equal numbers of X and Y sperms, and fertilization is a random process i.e. X and Y sperms have equal chance of fusing with an oocyte. This ensures the 1:1 ratio of men: women in human populations, and makes it impossible for most men of any population to indulge in polygamy. Even if we assume that, in a population of 1000 people (500 men and 500 women), 100 men marry 3 women each, it means there will now be 400 unmarried men but only 200 unmarried women. Thus, some men will not be able to find a wife and will not have any children, thereby averaging out the growth of the entire population. The take-home message is that it is scientifically absurd to imagine that any human population could overgrow in such fantasising ways. Period.

To conclude

It is not doubted that people moved in and out, especially in the aftermath of the colossal tragedy of the partition and the political instability that gripped Bangaldesh later. But, the national and international data just does not reflect enough recent movement that can radically alter the demographics of WB. Rather, the census reflects a success story. Contrary to common knowledge, Indias population juggernaut has clearly slowed down. Some states like WB have done better in this regard, others have to buck up. But undoubtedly, since 1991, India has slowly but steadily moved towards solving the major problem of unbridled population overgrowth. In a more scientifically-tempered nation, this would be a cause for self-congratulation. This would also be a pedestal to address the existing lacunae and for harnessing the potential of our demographic dividend; the biggest population now is in the age of 15-63 years now i.e. the working age, availability of jobs would have unleashed a true Indian 21st century. Instead, a lack of scientific outlook towards facts within our society continues to add to faulty perceptions, bluffs and such bitter estrangement among Indians.

Souvik Bhattacharyya is a molecular microbiologist working on bacterial population dynamics at Texas, USA. Anirban Mitra is a molecular biologist and teacher, based in Kolkata.

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What Does Demography Reveal About Immigration Into West Bengal? - The Wire

Thinking about using donated eggs to start a family? – Pursuit

Starting a family is an exciting and scary decision at the best of times. For some women and couples, theres the added complication of thinking about assisted reproduction methods such as IVF.

While some women use their own eggs, others might need or want to use donated eggs. In Australia and New Zealand, over 3,000 IVF cycles were performed using donor eggs (or embryos) in 2017 with 707 live births reported.

Donor eggs are used for a number of reasons.

IVF treatments using a womans own eggs have a success rate of only around 30 per cent, so donors might be used to increase the chances of success. Donor eggs might also be needed for surrogacy, or for survivors of illnesses such as cancer.

But when it comes to donor eggs, there are several options.

Women might seek donors in Australia, where the market for donor eggs is intensely regulated and differs significantly per state.

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In Victoria, human eggs can only be gifted from donor to recipient as per Section 17 of the Prohibition of Human Cloning Act 2008 with other Australian states having similar legislation (albeit in the Northern Territory it is just being drafted).

Australian donors also receive limited compensation with estimates of around $A5000 per cycle, however this varies by clinic.

It can also be quite a challenge to find a potential donor and negotiate a relationship.

Women might not think about becoming a donor unless asked. Many women post on a Facebook group or an online forum hoping to find donors.

In Australia and New Zealand, just over 1,100 treatment cycles were performed from women intending to donate eggs in 2017.

Alternatively, recipients might look overseas for donors or frozen donor eggs, often in markets with much less regulation.

Our research looks particularly at the unregulated market for donor eggs in the US and how agencies find potential donors.

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Unlike in Australia, where eggs must essentially be gifted, in the US theres a big emphasis on donating eggs as a way of earning extra income.

Assisted reproduction has turned into a global business, with some Australians travelling overseas to find donor eggs or embryos.

Donor eggs can also be imported into Australia from the US from organisations like the World Egg Bank. Of the various countries where Australians might look for donor eggs, we focused on the US for comparison, particularly on the recruitment efforts for donors.

In the US, most donor eggs are matched through agencies.

Our research looked at ads from donor egg agencies that were used to recruit egg donors.

These were easy to find but reveal a lot about the industry.

We examined more than 400 ads posted on US classified website Craigslist. Most were listed as job ads, highlighting the way donation is framed as a form of work. Additionally, any compensation for US donors is considered taxable income by the US tax agency.

Similar to adoption or sperm donation, matching considers attributes like eye colour, height, ethnicity and other features. Ads offered to pay more for Ivy League graduates.

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While some ads were more general, others read like a shopping list of attributes, from high standardized test scores and high intelligence to a height of over 56.

These more specific ads often offered more money, and we even saw offers of up to $US100,000.

Money was explicitly mentioned in all of the donor recruitment ads that we analysed (for instance, our couples are willing pay $6000 and up to $15000). But they also marketed egg donation as an altruistic gift (Donating eggs is a gift of love and hope).

The ads featured both aspects of egg donation, though in different combinations and levels.

While the US market has never been as strongly regulated as Australia, there used to be suggested guidelines for paying donors.

These recommended that Total payments to donors in excess of $5,000 require justification and sums above $10,000 are not appropriate.

But in 2015, a group of donors banded together and sued the reproductive industry body, using anti-trust regulation to argue that compensation suggestions were a form of illegal price fixing and they won.

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In the face of this focus on money, one interesting finding from our research was that recruitment ads with a smooth blending of these logics gift and money were more persuasive for the reader.

We suspect that although some agencies might want to simply focus on the money, to attract donors it may be helpful to retain a focus on altruism, given the ethical values of fertility clinics and medical providers performing the actual services, let alone what recipients are seeking.

There are pros and cons to however you choose to find donated eggs.

In Australia, it can be hard to find donors and negotiate a relationship. In the US, browsing through inventories may feel too much like shopping.

But whatever you choose, its important to be informed about the different ways that donor eggs are regulated and what to expect.

Banner: Getty Images

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Thinking about using donated eggs to start a family? - Pursuit

Expert Fertility Doctor Promotes Increasing Measures To Avoid IVF Mix-Ups – PR Web

As physicians, we take an oath first of all to do no harmand to make a mistake in embryo or egg or sperm identification is to do very grave harm indeed. In the fertility field, we see patients at a highly vulnerable point in their lives, and we become the custodians of their hopes.

ORLANDO, Fla. (PRWEB) February 10, 2020

In March of last year, a New York City woman gave birth to twins conceived in vitro after years of infertility challenges. After the birth, the couple were stunned to discover that the IVF clinic had implanted the wrong embryos: the twins were biologically related neither to the couple nor to each other. The parents have filed suit against the fertility clinic, as have the biological parents of one of the babiesvictims of the same mix-up. (1) A mistake like this is simply devastating, says Dr. Mark P. Trolice, M.D., FACOG, FACS, FACE, Director of Fertility CARE: The IVF Center, and Professor of Obstetrics and Gynecology at the University of Central Florida College of Medicine. Instead of joy, it brings pain and chaos into the lives of both parents and children.

To prevent such errors, says Dr. Trolice outlines in his recent publication (7) that it is incumbent on fertility practitioners to maintain the highest possible standards of care and accuracy, so as to avoid the kinds of situations reflected by these errors and the lawsuits that inspired them. His own practice, for example, is soon implementing technology for bar code identification of patients along with their egg, sperm, and embryos.

This degree of systems management, says Dr. Trolice, should become standard for the industry, noting that these errors, fortunately rare, are often attributed to human error but should not be considered inevitable. There are also egregious acts, committed by a Canadian fertility doctor whose license to practice was recently revoked. He was caught using the wrong sperm (including, in some cases, his own) in the assisted conceptions of more than 70 children. (2) He is now the subject of million-dollar lawsuits by two former patients. (3)

Meanwhile, the infertility field is expanding rapidly, as is investors interest in it. Research from Piper Sandler projects that the U.S. fertility market will be at $15.4 billion by 2023, up from about $7 billion in 2017. Last October, fertility benefits provider Progyny became one of the first startups in the industry to go public; since then its stock price has increased more than 150%.(4) In addition to market attention, the dramatic possibilities inherent in IVF mix-ups are being explored in popular culture, first in an Australian best-seller that served as the basis for a television series(5), and more recently in an American adaptation on the Fox network.(6)

Dr. Trolice, whose views on the subject are shaped not only by his professional standing but by his own ten-year history as an infertility patient, says, As physicians, we take an oath first of all to do no harmand to make a mistake in embryo or egg or sperm identification is to do very grave harm indeed. In the fertility field, we see patients at a highly vulnerable point in their lives, and we become the custodians of their hopes. We may not always be able to make things better for them, but we canand we mustavoid committing the kind of errors that make things worse.

About Fertility CARE: The IVF Center

Fertility CARE (Center of Assisted Reproduction and Endocrinology): The IVF Center provides patient-centered, evidence-based, and individually customized reproductive care in a comfortable and compassionate setting. This Central Florida IVF clinic, in the Orlando/Winter Park area, consistently earns 5-star patient ratings in online reviews. Established in 2003 by founder and director Dr. Mark P. Trolice, uniquely offers both male and female testing, evaluation, and treatment. Today, the practice encompasses the Center for Male Infertility, headed by a fellowship-trained male reproductive specialist; the Mind/Body Institute, overseen by a licensed clinical reproductive psychologist; and the IVF Laboratory of Central Florida, led by a Board-certified High-Complexity Laboratory Director. Fertility CARE: The IVF Center offers a comprehensive range of infertility tests and treatment options as well as genetic testing, egg freezing, embryo cryopreservation, and other services. For full details, visit http://TheIVFCenter.com.

About The Fertility Doctor's Guide to Overcoming Infertility: Discovering Your Reproductive Potential and Maximizing Your Odds of Having a Baby

The Fertility Doctors Guide to Overcoming Infertility: Discovering your Reproductive Potential and Maximizing Your Odds of Having a Baby is a non-fiction infertility book written by Mark P. Trolice, MD, FACOG, FACS, FACE; Director, Fertility CARE: The IVF Center Professor of Ob/Gyn at the UCF College of Medicine. This book is to be used as a companion guide through every step of an individuals infertility journeya guide that explains the most optimal time to conceive, advises the right time for an evaluation by a fertility specialist, recommends evidence-based diagnostic testing and treatment including IVF, and discusses alternative family building such as egg/sperm donation, surrogacy, and adoption. Buy the book on Amazon or visit Dr. Trolice via his professional website http://drmarktrolice.com

1.Miller, Anna Medaris, A couple is suing a fertility clinic after giving birth to two other couples babies. Heres how that can happen, Insider, July 10, 2019.2.Pfeffer, Amanda, Disgraced fertility doctors clinic broke federal rules as far back as 1999, inspection results reveal, CBC News, January 6, 2020.3.Sperm mix-up charges raise concerns about fertility clinics, CBC News, September 14, 2010.4.Kowitt, Beth, Fertility Inc.: Inside the big business of babymaking, FORTUNE, January 21, 2020.5.IVF, swapped embryos and unimaginable heartbreak: Why The Mothers has made us question everything, Australian Womens Weekly, January 23, 2020.6.VanDerWerff, Emily Todd, Foxs Almost Family aims to build a quirky family dramedy around medical rape, Vox, October 6, 2019.7.Fertility and Sterility. IVF Errors: Is This Only the Tip of the Iceberg? Fertility and Sterility Dialog, Fertility and Sterility, 6 Feb. 2020.

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Expert Fertility Doctor Promotes Increasing Measures To Avoid IVF Mix-Ups - PR Web

EASTERN AFRICA: Locusts invasion, another impact of climatic fluctuations – AFRIK 21

East Africa has been hit by a locust invasion on an unprecedented scale for several decades. In Somalia and Ethiopia, about 70,000 hectares of agricultural land have already been destroyed. Meanwhile, in Kenya, swarms up to 60 kilometres long and 40 kilometres wide have been observed, causing significant damage to agricultural production. According to the Food and Agriculture Organization of the United Nations (FAO), locusts can eat the equivalent of the food consumed by 80 million people in a single day.

The challenge for the sub-region is to find ways to limit the multiplication of these insects. The challenge for the sub-region is to find ways to limit the multiplication of these insects because Southern Sudan and Uganda are also under threat and can be attacked overnight, says Keith Cressman, a locust invasion specialist for the Food and Agriculture Organization of the United Nations (FAO), in an interview with the newspaper Le Monde. Even more so since a very large number of larval bands have been observed and new generations of these insect pests are expected to hatch in the coming weeks.

West Africa is not threatened, but the situation is such that governments in surrounding countries are also afraid of the consequences and are trying to take measures to deal with them. In Burundi, the Minister of Agriculture and Livestock held a press conference on February 4, 2020, to present the strategic axes of his action plan to the populations.

The authorities set up an inter-ministerial monitoring committee and a commission in charge of technical monitoring. Also as part of the response, a campaign to raise awareness among the population on the collection and consumption of locusts was launched. This would reduce the number of locusts to preserve crops in case of attack.

However, these measures are unlikely to be very effective in the face of a phenomenon that experts attribute to climate change on an exceptional scale.

East Africa is one of the areas most affected by climate change. According to specialists, it is caused by an ocean-atmosphere interaction phenomenon called the Indian Ocean Dipole. The climate phenomenon is created by the difference in sea surface temperature between the eastern and western zones of the Indian Ocean. According to scientists, a dipole of such intensity has not been observed for years or even decades.

This climate disruption has created ideal conditions for insect reproduction. During periods of calm known as recessionary periods locusts are generally restricted to the semi-arid and arid deserts of Africa, the Near East and South-West Asia, which receive less than 200 mm of rain per year.

According to Richard Munang, a United Nations Environment Programme expert on climate and Africa, The last five years have been the hottest since the Industrial Revolution. Studies have linked a warmer climate to more threatening locust swarms. Wet weather also encourages locusts to multiply.He also noted that widespread and above-average rains up to 400% above normal hit the Horn of Africa from October to December 2019. These abnormal rains were caused by the Indian Ocean dipole, a phenomenon accentuated by climate change.

Kenya is plagued by locust invasion since late December 2019. The Kenyan government now fears that the threat is spreading to grazing areas. A possibility that would be devastating for pastoralists. And if the locust threat has not been contained by the start of the next planting season, around March, farmers could see their fields destroyed.

To reinforce control, the country has therefore called on private companies, such as Farmland Aviation, which specialises in fertiliser spraying. Kenya now has five aircraft that spray pesticides on locusts. Even if, as Richard Munang reminds us, the impact of these chemicals on the environment and other ecosystems essential to food security cannot be neglected. For example, bees and other insects pollinate up to 70 percent of our food. Not to mention the direct impact of pesticides on human health. If nothing is done, the number of insect pests could be multiplied by 500 by the month of June, said Friday Guleid Artan, from the Climate Prediction and Applications Centre (ICPAC), part of the Intergovernmental Authority on Development, quoted by the magazine Science et Avenir.

Ins Magoum

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EASTERN AFRICA: Locusts invasion, another impact of climatic fluctuations - AFRIK 21

Chemistry Club wins the 2020 ‘Battle of the Chemistry Clubs’ competition – MSUToday

Michigan State Universitys Chemistry Club took first place in the 13th annual Battle of the Chemistry Clubs, or BCC, competition held Feb. 1.

The MSU Younger Chemists Committee sponsors the annual BCC competition to attract chemistry clubs from throughout Michigan. Held on the MSU campus, this years competition included 10 colleges and universities in teams of at least four students each. The BCC first began as a competition between UM-Flint and the University of Detroit, Mercy, in 2007.

"On behalf of the department, I congratulate our Chemistry Club champions, said Robert Maleczka, professor and chair of the Department of Chemistry in the MSU College of Natural Science, or NatSci.This group of chemistry majors has shown a great esprit de corps and are terrific examples of students getting the most out of their MSU experience.A shout-out to the clubs advisor, Sheba Onchiri, is also most certainly in order!"

I consider such competitions as one of the best ways to demonstrate students talents, Onchiri said. If we fail to provide these kinds of forums, some students may not discover their hidden talents and other skills they possess. Above all, these events help students build self-confidence, teamwork and other soft skills vital in the world today. I am so proud of the Chemistry Club and all they have accomplished in the short time they have been in operation. Go Legends!

BCC events cover a full day. Competitive events in the morning include chemistry Jenga, a safety rules obstacle course, identifying elemental trivia in haiku poems and tests on International Union of Pure and Applied Chemistry, or IUPAC, knowledge. IUPAC is the unified system of nomenclature, measurements and atomic mass values for chemists. MSU dominated in all these categories and held first place after the mornings events.

"Our expectation as we were waiting for the results of the morning was just to be in the top five, said Natasha Perry, MSU Chemistry Club vice president.

MSU's club continued to hold its lead throughout the afternoon in the titration race and in timed events that tested students knowledge of density laws and regions of the visible light spectrum. The competition closed with jeopardy-style trivia questions on a variety of chemistry knowledge before moving on to the Final Jeopardy round and winning the competition.

When we found out that we won, we were at first speechless, Perry said. I know that winning will allow our club to flourish and was an exceptional way for seniors to finish their last year."

A senior, Perry plans to pursue a Ph.D. in organic chemistry, with a focus on either organometallics or total synthesis. She is still deciding which graduate program to attend.

I believe this success at the BCC will be very important for the future of MSU's Chemistry Club in attracting members, said Austin King, MSU Chemistry Club president, who started the club in spring 2019. Having fun and being passionate about chemistry is the clubs main focus; students will see the accomplishments the club has made and want to be a part of it.

King will start graduate school in chemistry at MSU in the fall and looks forward to seeing new members help the club continue to grow.

MSU's Chemistry Club fosters and promotes passion for chemistry among students, who come from a variety of backgrounds and majors but share a common desire to expand their knowledge of the world around them. The club focuses on having fun and exploring chemistry topics rarely addressed in standard colloquia. Club members enjoy exploring some of the unusual as well as the practical applications of chemistry.

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Chemistry Club wins the 2020 'Battle of the Chemistry Clubs' competition - MSUToday

How this chemistry professor is grappling with molecular models in hopes of making big breakthroughs – The College of New Jersey News

Associate Professor Joseph Baker with chemistry students Jonathan Piscitelli 21, Kevin Marin 21 and Emma Webb 21.

If youve ever needed antibiotics, youre familiar with the destructive power of bacterial cells. Bacteria can accumulate on everyday surfaces and cause illnesses from strep throat to pneumonia.

With their amazing powers of adhesion, these cells can cling to surfaces, join together to form colonies, and even move around. Hair-like appendages made of proteins called type IV pili extend from the bacterial cell, grab onto surfaces and then contract, pulling the cell forward like a grappling hook.

Joseph Baker, associate professor of chemistry, is taking a closer look at these grappling hooks in order to better understand their role in the infection process. His research could help uncover revolutionary new medical treatments.

A physicist by training, Baker has worked in the chemistry field since receiving his PhD from the University of Arizona in 2011. With my physics background, the way that I try to understand these protein systems is from a model-based approach, he says.

Now, with help from TCNJs Electronic Laboratory for Science and Analysis (a high-performance computing cluster affectionately known as ELSA), Baker and his team of TCNJ students (nearly 20 over the last five years) are using a computational method called molecular dynamics simulation to analyze the movements of the pili. This method works by calculating the interactions between atoms in the simulated system (in some cases hundreds of thousands or millions of atoms) and then using Newtons laws of motion to determine how the pili moves through time, essentially creating a movie of the molecular motion.

Specifically, Baker is interested in understanding how type IV pili respond to tension forces. As the grappling hook stretches and grabs onto a new surface, its structure changes.

Its like taking a string and pulling on it. The string will stretch a bit and so will type IV pili when they are pulled on, says Baker.

Understanding these structural changes could have groundbreaking practical implications. Researchers could theoretically develop a molecule that would sever the pili during adhesion, preventing bacterial infection.

Bakers research could have another important application: drug delivery. Hollowed out pili could act like nanotubes similar to a straw that is thousands of times thinner than human hair aiding in the transport of drug molecules into infected or cancerous cells and potentially helping to combat disease.

With his simulations, Baker will explore the kinds of molecules that could move through these hollow structures, and investigate their application as novel nanoscale biomaterial devices.

With support from the Gitenstein-Hart Sabbatical Prize, Baker will spend his sabbatical year at Northern Arizona University working with his theory collaborator and others at the universitys Center for Materials Interfaces in Research and Applications, to further develop his research.

Sarah Voorhees 20

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How this chemistry professor is grappling with molecular models in hopes of making big breakthroughs - The College of New Jersey News

Adapting to climate change: How chemistry will help us thrive – Chemical & Engineering News

This is what climate change looks like: Growing numbers of people struggling to find abundant clean water or to grow their crops in the face of higher temperatures, volatile weather patterns, and degrading soils. Wildfires raging through the Australian bush, killing an estimated half a billion animals, and more on the way. Floodwaters from extreme storms infiltrating coastal industrial plants and combusting vats of chemicals, putting workers and other people at risk.

Climate change is happening, and scientists have warned the world to brace for more intense heat waves, longer fire seasons, more frequent extreme storms, and an acidifying and warming ocean, among other consequences. It is increasingly urgent to act now, they say, not only to reduce the greenhouse gas emissions that drive climate change but also to fortify ourselves against a changing Earth. We must take aggressive, rapid steps to mitigate climate change and prevent conditions from worsening, experts say. But some of the damage is now unavoidable.

To protect human lives, critical infrastructure, crucial ecosystems, and the economy, the world must adapt to climate change. The nonprofit Global Commission on Adaptation is calling for scientists and governments to meet a moral responsibility to respond in a way that improves lives and livelihoods for all. The effects of climate change will hit hardest in developing countries and small island nations. And these challenges coincide with a predicted surge in population growth.

With adaptation, there is also opportunity. As the commission writes in a 2019 report, adaptation can deliver additional social and environmental benefits that bring with them economic and environmental justice. Climate change is frightening, but there are solutions, and chemists will play a critical role in helping the world thrive.

In this issue, youll learn how scientists are tackling some of the biggest problems caused by climate change and turning them into opportunities, including feeding the world by improving access to high-quality proteins and greener pesticides, protecting our coral reefs with high-tech breeding methods, and steeling our cities against natural disasters with innovative materials science. Well also delve into how the chemical industry is learning from past disasters to safeguard its infrastructure and look at the policy changes and educational strategies we need to ensure climate resilience.

This is what adaptation to climate change looks like. Read along, and let us know how youre contributing by writing us at edit.cen@acs.org. We may share your story in an upcoming issue of C&EN.

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Adapting to climate change: How chemistry will help us thrive - Chemical & Engineering News

Why sacrificing chemistry for cash is one of the biggest mistakes agencies can make – PRWeek

However, experience tells me that overlooking bad chemistry with a future client because it involves a sexy brand name and big budget is the biggest mistake an agency can make.

The thing is, you cant force chemistry; its a gut feeling, an emotion, and it cant be scored with a number.

But we know most business models are built around bringing home the bacon cold, hard cash.

New business teams are tasked with expanding the pipeline and jumping at every possible chance to add to the companys bottom line.

The idea of turning down work based simply on the mood in the room seems ludicrous.

But while its no secret that chemistry is important to every successful relationship, we must not underplay its significance in producing the very best work from agencies.

A relationship based on trust and respect and, lets be real, basic manners is always going to triumph and accomplish better things than one based on lack of trust and a reluctance to engage.

You can mainly tell from that initial 60-minute face-to-face meeting how a relationship is going to go.

Just like in a happy marriage, fundamental, respectful human behaviours hold things together.

It helps keep energy levels high through the ups and downs of a campaign and maintains the magic that keeps creativity flowing and results flooding in.

The tension between profit and positive working relationships is an emotional dichotomy and believe me, Ive learned this the hard way.

Short-term gain for the P&L often leads to long-term pain if the fit just isnt right; bad team morale, over-serviced accounts, staff resignations and, ultimately, leaving an agency worse off than if it had just said its polite goodbyes at the chemistry meeting and walked away.

Instinct and smart business sense tell us to partner brands and clients that share similar values.

But do we do it enough? Probably not.

PRs needs to get better at giving potential clients their own feedback after chemistry meetings.

Rather than a one-way street of clients score-carding agencies, PRs need to set their own standards and criteria for prospective clients and stick to them.

These include shared values and cultures, engagement and attention to the conversation or presentation, as well as passion, enthusiasm and energy.

How many times have agencies turned up to chemistry meetings with key decision-makers checking emails or typing away at laptops?

These behaviours can be signs of how a future relationship might turn out.

Agencies need to experience how empowering it is to turn down work because you respect your talent and team too much to put them through the pain of working with bad clients.

Good chemistry results in a motivated workforce, better results and, ultimately, more like-minded clients.

Its a cycle of good energy.

So, when do you say no? How do you know when enough is enough?

Unfortunately, its not an exact science.

Yes, there are some obvious signs but really, your best guide is your gut. Your natural intuition is the one thing that never lies; you just have to trust it and be brave.

Sometimes the chemistry just isnt there even if the money is.

Natalie Neave is a director at Tin Man Communications

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Why sacrificing chemistry for cash is one of the biggest mistakes agencies can make - PRWeek

Chemists complete synthesis of molecule ‘at the limits of complexity’ – Chemistry World

A team of chemists at the University of Konstanz, Germany, has managed to synthesise one of the most complex natural products ever isolated: canataxpropellane. The research could lead to more efficient syntheses of the taxane family of compounds, which includes the anticancer drug Taxol (paclitaxel).

Taxanes were originally found in extracts of the Pacific yew tree (Taxus brevifolia) and since Taxols discovery, over 500 different taxanes have been isolated from Taxusspecies in a hunt for other medicinal compounds. The densely functionalised structure of canataxpropellane has always tantalised researchers, who wondered how its tighter, more congested scaffold might affect its anticancer activity. However, chemists have never sourced enough to test its bioactivity, and its total synthesis has remained elusive because of the formidable synthetic challenges posed by its structure.

A heptacyclic cage-like structure, twelve contiguous stereocentres, and six contiguous all-carbon quaternary centres these are each significant challenges in and of themselves, explains Sadie Otte, from Claremont Colleges in California in the US, who was not involved in the work. Phil Baran, at Scripps Research in La Jolla, US, adds that compounds with this level of functionalisation not only are challenging from a planning standpoint, the actual execution is always stymied by problems, from unanticipated reactivity to selectivity issues.

Now, the team led by Tanja Gaich has prepared the intricate taxane in just under 30 steps. Gaich explains that overcoming the routes planning and execution challenges tested the teams ingenuity and patience: Sometimes, we needed really aggressive deprotection conditions that almost destroyed our molecule, but it was the only way we found around it. In fact, the researchers came close to giving up at the very first reaction finding the precise conditions for that DielsAlder transformation was quite tedious, explains Gaich. The diene we used is very unstable, it either led to decomposition or self-polymerisation.

The researchers also prepared enantiomerically pure ()-canataxpropellane. Developing the chiral version of the route took the researchers two additional months in the lab. But this extra challenge also led the team to discover a new chiral directing group for the asymmetric DielsAlder reaction, when other chirality-inducing solutions Lewis acids, iminium catalysis just didnt work. When we thought of bulky, chiral siloxanes we hit the spot, says Gaich. These protecting groups also allowed the team to separate the two diastereomers using column chromatography instead of HPLC, making multi-gram scales easier to tackle. And obtaining decagrams of some intermediates is key to get canataxpropellane in quantities suitable for biological activity studies, explains Otte.

Both Baran and Otte agree that the synthesis strikingly elegant. Canataxpropellane is at the limits of complexity, says Baran, who also thinks this new route gives hope for accomplishing a short and scalable synthesis of taxanes, including a more efficient route to Taxol itself.

Canataxpropellane also belongs a family of around 30 cyclotaxanes that have never been prepared before. So the teams synthesis could become the starting point towards synthesising all these products: We could now selectively fragment some of the bonds to obtain its other cousins, and hopefully understand the relationship between a constrained structure and biological activity, explains Gaich.

Total synthesis of canataxpropellane

Source: Science/AAAS

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Chemists complete synthesis of molecule 'at the limits of complexity' - Chemistry World

Department of Chemistry wins Regents’ Diversity Award Creating Community – University of Wisconsin-Madison

The University of WisconsinMadisonDepartment of Chemistryhas received a 2020 Diversity Award from the University of Wisconsin System Board of Regents. The award recognizes the departments efforts to enhance underrepresented students access to and success in the chemistry graduate program.

This award celebrates a key point in our progress toward fostering greater diversity in our discipline and is just the beginning of our efforts says Judith Burstyn, department chair. These achievements are the result of everyone in the department who works tirelessly to build diversity through the creation of key programs and mentorship of students.

The field of chemistry has long lacked diversity. According to theAmerican Chemical Society(ACS), the number of females receiving bachelors degrees in the discipline is increasing, but the number of doctoral recipients, postdoctoral scientists, and professional chemists who stem from other traditionally underrepresented populations is still low.

Members of the Department of Chemistry Climate and Diversity Committee include: Front row, from left: Desiree Bates, Robert Hamers, Judith Burstyn, Karen Stephens, Kristi Heming, AJ Boydston, and Heike Hofstetter. Back row, from left: Wesley B Swords, Zachary Jones, Silvia Cavagnero, Sam Wood, Matthew Sanders, and Cheri Barta. Not pictured: Andrew Greenberg.PHOTO BY TATUM LYLES FLICK

Everyone benefits from diverse perspectives, says Burstyn. We recognized that need in our department and have worked to find effective solutions.

The Department of Chemistry has created several programs aimed at increasing diversity in the field and at supporting students who pursue a graduate degree.Chemistry Opportunities (CHOPs), which brings in students from minority-serving institutions, andResearch Experiences for Undergraduatesboth facilitate undergraduate exploration of the departments doctoral program. For graduate students, the department offersCatalyst, a supportive mentoring program for underrepresented minority and first-generation students.

The strength and effectiveness of the first three programs led the ACS to select the department as its first partner for aChemistry Bridge to the Doctorateprogram, which aims to increase the number of doctoral degrees completed by underrepresented minorities. A select group of students bolster their experience and applications to top PhD programs by completing a research-based masters degree, with the benefit of well-coordinated mentorship.

Consistent with UWMadisons commitment to recruit, retain and graduate a diverse student body, the Department of Chemistry embraced their role in supporting diversity by creating highly effective initiatives to increase representation within their large graduate program, says Gloria Mari Beffa, associate dean in the Colleges of Letters & Science, in her nomination letter.

The Board of Regents awards the winners $7,500, which the chemistry department will use to support its programs. The Diversity Awards are administered by the UW System Office of Academic and Student Affairs. The other recipients are Associate Professor Arijit Sen, from the UWMilwaukee School of Architecture and Urban Planning, and UWStouts Fostering Success program. The three winners will be recognized at the Feb. 7 meeting of the Board of Regents in Madison.

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Department of Chemistry wins Regents' Diversity Award Creating Community - University of Wisconsin-Madison

Q&A: Chemical Biologist Ken Hsu to Use NSF CAREER Award to Fight Cancer – University of Virginia

A promising University of Virginia scientist, Ku-Lung (Ken) Hsu, an assistant professor of chemistry, has earned one of the National Science Foundations coveted Early Career Development Program Awards, which support junior faculty members who perform outstanding research and are regarded as exceptional teachers.

Part of the grant is used to integrate education and research in academic activities. Hsus award is for $681,000.

Hsu uses chemistry to control biological systems, particularly to modify the immune system to become an active combatant against cancer. His work understanding and controlling the inflammation response spans the search for new non-addictive drug options for treating pain, to modifying immune cells so they can recognize and kill cancer cells.

The five-year NSF CAREER grants are among the most prestigious available to young faculty in science and engineering, and are designed to provide significant resources to the early stage development of careers.

Many of Hsus laboratory studies are conducted in collaboration with clinical researchers in the School of Medicines Cancer Center as part of UVAs efforts to enhance research into precision medicine using immunotherapy to target life-threatening diseases at the fundamental molecular level.

Hsu discusses here his research and grant for readers of UVA Today.

Q. What drew you to this area of chemistry?

A. Chemical biology is an exciting area of chemistry because it is very creative, highly interdisciplinary and allows scientists to answer fundamental questions that ultimately improve human health through drug discovery and other new therapies. I enjoy the opportunity to work with experts in so many different fields, including pharmacology, pathology, neurology and cancer biology. As a result, I learn something new from each project.

My students also benefit greatly from being in this field because of an emphasis on collaborations, which increases diversity through individuals they interact with and expands the skillsets they obtain during their training. Medical research is becoming increasingly collaborative, so my students are becoming well-prepared for the research environments in which they will spend their careers.

Activating the immune response to fight cancer represents a very exciting treatment modality and UVA is well-positioned to be a leader in this front. The UVA Cancer Center has been a major supporter of my research program, and I look forward to continued interactions and collaborations in this community.

- Ken Hsu

Q. Describe the most compelling aspects of your latest research.

A. I am excited about two recent discoveries that embody research from our group in the field of chemical biology. Both reports are published in the journal Nature Chemical Biology.

In our first paper, we describe a new chemical reaction with broad applications for synthetic chemistry and drug discovery. The reaction we discovered possibly could come into common use for developing new treatments for cancer and other diseases in the future. This finding was especially rewarding because I teach related material in my organic chemistry course and our paper describes a new methodology for synthetic chemists and chemical biologists to tune chemical reactions for diverse real-world applications. This is compelling for my students, to know that what they are learning in class is also current and active to catalyze breakthrough research in our labs.

In our second report, our findings are directed toward fundamental discoveries in the realm of fat (lipid) molecules, which play a major role in the bodys metabolism at the cellular level. We used protein engineering to design artificial lipid kinase enzymes a specialized protein involved in cell growth, proliferation and other functions that can include the growth of cancers in order to better understand how cells regulate their fat composition. To our surprise and delight, we narrowed in on a very specific region of these lipid kinases that allow us to control how they operate in cells. Our findings will teach us and others in the field a more effective way to design therapeutics to combat these enzymes when they misbehave.

Q. How will this grant allow you to connect your research with teaching?

A. The NSF CAREER Award will provide new opportunities for applying our chemistry and technologies to study how individual cells control the metabolism of fats and lipids. We plan to develop compounds that attach to enzymes to illuminate how cells are similar or distinct based on their metabolism kind of like a molecular fingerprint. Our long-term goal is to create new opportunities for cell type discovery and push the boundaries of cell engineering.

The research is intimately connected to an educational outreach program designed to broadly impact Native American student communities by providing opportunities for UVA graduate students to teach how lipid biochemistry influences healthy food choices and eating behaviors in society.

Q. Where do you see your research going from here?

A. In the next five years, I am looking forward to applying our chemistry and technologies toward deeper understanding of lipid biology and metabolism in physiologically relevant models. We remain committed to discovery of new molecular pathways for immune system modulation, and our recent findings represent important steps toward our long-term goal.

Q. How promising is the future regarding immune system modulation?

A. Activating the immune response to fight cancer represents a very exciting treatment modality and UVA is well-positioned to be a leader in this front. The UVA Cancer Center has been a major supporter of my research program, and I look forward to continued interactions and collaborations in this community.

I believe the chemistry we are pursuing will provide new opportunities and technologies for exploring creative ways to study and control the immune system. Support from the NSF CAREER Award will pave the way for new ways to engineer immune cells for cancer and other potential disease indications.

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Q&A: Chemical Biologist Ken Hsu to Use NSF CAREER Award to Fight Cancer - University of Virginia