The Next Generation’s Genes – The Regulatory Review

Scholars are divided on how to regulate heritable genome editing.

Heritable genome editing refers to changing human reproductive cells so that the resulting fetus has genetic changes that its future offspring may inherit.

Proponents of heritable gene-editing champion the possibility of editing out incurable heritable diseases, but others caution that gene editing may have unintended effects. For example, an edit to prevent a child from inheriting a disease might also reduce that childs immunity to other diseases, a concern that is amplified by the fact that any changes to immunity would be heritable.

The debate is no longer theoretical. Shortly after reports of the first live births of gene-edited babies surfaced in 2018, a number of prominent scientists called for a ban on any further experimentation that would result in live births, at least until regulatory schemes were put in place.

This weeks Saturday Seminar explores scholarly works on current and proposed regulatory approaches to heritable gene-editing, as well as the unique challenges to effective regulation given factors like the medical tourism industry.

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The Next Generation's Genes - The Regulatory Review

UC Davis leads in innovative gene editing research with NIH grants – The Aggie

Researchers strive to address societal health issues through gene editing

In October, three researchers at UC Davis were awarded a $1.5 million grant to fund their project which attempts to demonstrate the effectiveness of gene editing through use of CRISPR, a powerful technology that allows alteration of DNA sequences to change gene function.

This kind of design can help enhance personalized medicine, said R. Holland Cheng, a professor of molecular and cellular biology in the College of Biological Sciences. Specific patients with specific illnesses can be treated in specific ways.

Cheng, along with Kit Lam, a distinguished professor and chair of the Department of Biochemistry and Molecular Medicine in the School of Medicine, and David Segal, a professor in the Department of Biochemistry and Molecular Medicine, were awarded this highly competitive and sought-after grant from the National Institute of Health (NIH).

UC Davis is part of the NIHs Somatic Cell Genome Editing (SCGE) consortium which has awarded grants to 45 other research institutes across the nation so they can begin groundbreaking work on gene editing. Through this consortium, the NIH hopes to find an efficient and safe way to conduct gene editing. Research programs are investigating the best delivery mechanism as well as the most dynamic gene editing tool.

The major problem with gene editing currently is the inability of cells to be edited within a living organism. It has become fairly easy and efficient to edit genes in a cell culture outside of the body but extremely difficult to do the same processes inside the body. Cheng, Lam and Segal are focused on changing this.

The question is how to do it inside of an animal and eventually a human, Lam said.

They are answering this question by utilizing Chengs work in engineering a non-toxic nanoparticle that they hope can transport the gene editing tool CRISPR into the cells of a living organism. Cheng has been able to create a Hepatitis E viral nanoparticle (HEVNP) that when manipulated could be a delivery system for CRISPR. They plan to take this nanoparticle and encase CRISPR inside of it, producing a mechanism for delivery of CRISPR.

The Hepatitis E nanoparticle has the capacity to be a highly efficient way to deliver gene editing to cells in the body due to its unique nature. HEVNP is resistant to the gastric acid environment of the intestines and stomach, enabling it to survive once its entered the body. Given its resistant abilities, HEVNP can be taken orally, making it a useful form of medicine. If able to successfully get HEVNP to the target cells in the body and deploy CRISPR, gene editing abilities could drastically change.

The addition of a cell-type specific targeting ligand to the HEVNP would code the nanoparticle to deliver CRISPR to a specific cell. The abilities of this method to be precise and safe will determine its success.

With five years of funding from the NIH, these three researchers are eager to begin work on this project and see the strides that can be made in gene editing. They have impressive goals for this research, as it has the capacity to reshape medicine.

This will redefine precision medicine as currently there is broad medicine that can cause side effects to people and not be effective, yet by making it specialized it is becoming more precise and effective, Cheng said.

As more effective and safe tools to cure illnesses are being tested and created, the benefits to society could be expansive. With so much potential to help improve the health of society, the NIH is dedicated to coming to new solutions at a quick rate. All programs that received grants will be required to share and utilize the research occurring at other funded programs. The NIH is hoping to eliminate the private nature of research through enforcing the sharing of ideas, as scientists are often constrained by the institutions they work for. It is their hope that by having communication between the programs, positive results will arise faster.

I think this is great because scientists inherently want to work with each other but have real world concerns especially with money, Segal said.

The research results, when groundbreaking, can provide incredible monetary gains and credibility to the institutions that made the discovery. Ultimately, scientists collaborating with one another will serve society as people are able to benefit earlier from this innovative research.

We want the public to know that we are working in their best interest, Segal said.

The NIH grant is competitive and still the third research program to join the consortium at UC Davis. Innovation has never been more prevalent than in this field at UC Davis. With three different programs researching gene editing, UC Davis stands out as a hotspot for this field of research.

Written by: Alma Meckler-Pacheco science@theaggie.org

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UC Davis leads in innovative gene editing research with NIH grants - The Aggie

Weining Lu, Kidney Researcher, Named BU Innovator of the Year – BU Today

Serendipity, love, change. These are just some of the forces that brought Weining Lu first to Boston, and then to Boston University, where he and members of his lab collaborated with Pfizer to develop a potential new drug that could offer new hope to the hundreds of millions of people around the world struggling with chronic kidney disease.

Academia and industry scientists working togetherthats a completely different research model than being funded by the National Institutes of Health or a foundation grant, says Lu, BU School of Medicine associate professor of medicine.

Lus hypothesis that a gene called ROBO2 could play a key role in moderating kidney function earned him an opportunity to collaborate with and receive funding from Pfizers Centers for Therapeutic Innovation (CTI) in November 2012, the first BU faculty member to do so. Now, with a promising new compound borne from the research collaboration in phase 2 clinical trials, Lu has been named BUs Innovator of the Year, an award bestowed annually on a faculty member who translates his/her world-class research into inventions and innovations that benefit humankind.

Translating basic research into real-world products, especially in the medical domain, is exceptionally difficult and not an area that many of our faculty are engaged in, says Gloria Waters, BU vice president and associate provost for research. It is very exciting to see one of our faculty members working to translate their basic research into a potential therapeutic that could have a tremendous impact on patients.

The novel drug candidate has made it through a phase 1 clinical trial and is currently in a phase 2 clinical trial.

Dr. Lus creativity and drive has made a [successful collaboration] with Pfizer that could serve as a blueprint for future [joint research programs] with biopharma, David Salant, BU School of Medicine vice-chair of research and professor of medicine, said in his letter nominating Lu for the award.

Lus path toward becoming a BU faculty member and developing a promising new kidney disease drug was full of obstacles. Born in China, Lu says hes fortunate that Chinas Cultural Revolution ended by the time he was 10 years old. Otherwise, [I] likely would have become a member of Chinas lost generationpeople who forewent the opportunity to attend university as most of Chinas institutions of higher education were closed during the [revolution].

At Zhejiang University, Lu earned a medical degree and then went on to complete his residency. I had a good life over there, he says. Lu was working as a hospital clinician until he discovered that a Chinese regulation called Hukou would prevent him from living with his future wife, whom he had met at medical school. Today its better, people in China have much more freedom. But then, this household registration system was in place, Lu says. It was difficult to move freely from one city to another.

Lu found himself at a crossroad. His brother, who had decided to move to the United States to pursue a new life, had immigrated to Boston, where hes the chief acupuncturist at Dana Farber Cancer Institute. Similarly, Lu and his wife thought, why not just go to Boston to start a new life, too?

And so they did. After moving to Boston, Lu was pursuing a PhD at Northeastern University when he was surprised one day to be invited to interview for a research position in the division of nephrology at Brigham and Womens Hospital. Id never applied for any position, though, Lu says. My wife, who was planning to have our first child, had submitted the application for me. And thats how I got into kidney research.

The job change turned out to be a catalyst for his path to BU. Serendipity is a fundamental part of scientific discovery, Lu says. After 10 years doing kidney and genetics-related research at Brigham, BU invited Lu to establish his own lab on the Boston University Medical Campus.

In my lab, we study patients with genetic defects related to their kidney and urinary tracts, Lu says. In his research, he noticed something special about the gene ROBO2 as it relates to a kidneys filtering ability. The observation led to a research collaboration with Pfizer, focused on ROBO2 as a potential drug target. ROBO2 is highly expressed in the developing kidney and urinary tract. We thought that lacking this protein or gene would cause kidney and urinary defects at birth and also adult kidney disease, so we studied this for several years. But our initial hypothesis was wrong, which was okay. Instead, we found that if you block or delete ROBO2 after birth, it could potentially help kidney function.

Although he wanted to publish the results of his findings, Lu took a gamble and held off in order to protect any potential patent rights that could be jeopardized by public disclosure. Over the course of seven years working in collaboration with Pfizer, Lu says hes experienced many challenges. Theres a different culture between academia and industry. The reward systems are completely different, and the habits and behaviors we have are different. In academia, to be promoted you need to stay funded and produce high-impact publications and grant funding.

In contrast, Pfizer says its focused on developing a molecule that can ultimately be translated into a potential therapy.

Deciding to take a chance on a non-traditional research route in collaboration with industry, which works at a different pace, plays by a different set of rules, and communicates progress in a different waythats a really hard choice for an academic researcher to make, says Michael Pratt, BU managing director of technology development. But it really accelerated the project. Lu took a risk and it paid off with the science.

Weining was focused on birth defects of urinary tract and kidney, but he followed the data he was getting [in the lab]. He said, I think I have a potential drug target for adults with kidney disease. So he changed his way of thinking, which is what being innovative is all about, says Steve Berasi, a senior director at Pfizer CTI whos been working with Lu since he first proposed collaborating on ROBO2.

Lu says it helps to keep the end goal in mind. In the case of ROBO2, it could be a significant game changer for the 37 million people in the US and 850 million people worldwide with chronic kidney disease.

Says Lu: I would say to persist and believe in your science.

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Weining Lu, Kidney Researcher, Named BU Innovator of the Year - BU Today

Why Designing Our Own Biology Will Be the Next Big Thing in Medicine – Singularity Hub

Its hard to watch a loved one get sick. Their eyes go glassy. Their breathing is punctuated by body-wracking coughs. Feverish and aching, they struggle to get out of bed.

Hard as these symptoms are to witness, theyre so familiar you dont need a medical degree to know its probably a bad cold and maybe the flu. Get some rest, hydrate, pop some ibuprofen, see a doctor if the symptoms significantly worsenand wash your hands, for heavens sake.

For most of history, however, even the finest physicians only slowly advanced beyond the basics of biology and medicine we take for granted. There have long been forms of diagnosis, treatment, and prevention, but these were rudimentary at best and superstitious at worst.

The history of innovation is not that excitinguntil you get to the 20th century, Jane Metcalfe, cofounder of Wired and founder of Neo.Life, told the audience at Singularity Universitys Exponential Medicine in San Diego this week.

Since then, biology and medicine have been on a tear, Metcalfe said. Early last century, doctors mastered blood transfusions and complex surgeries. They began controlling and eradicating infectious disease with sterilization, antibiotics, and vaccines and found drugs to manage pain.

Then, around the middle of the century, scientists began amassing a deep body of biological knowledgeknowledge were now using to manipulate the fundamental processes of living things.

Its a familiar story, but one that suggests something radical. Just as physics and chemistry have given humans power over the world of the inanimate, biology is giving us the ability to engineer living systems, from viruses and bacteria to animals and people.

Which is why Metcalfe thinks design could be the next big thing in medicine.

Well combat disease and improve human health by designing biological systems from the ground up. We can design embryos. We can edit genes in humans. We have synthetic biology. And so we really are looking at designing future humans, Metcalfe said.

The best known bio-design tool to date is undoubtedly CRISPR genome editing. With CRISPR, scientists are closer than ever to manipulating genes down to the letter.

There are now a number of increasingly refined CRISPR-based systems, the latest of which, CRISPR prime editing, has been described as a word processor for gene editing. Meanwhile, the first approved gene therapies are making their way (at times painfully) into cancer treatment.

Just last year, Metcalfe said, the world was shocked to learn a scientist in China, Dr. He Jiankui, had used CRISPR to edit human embryos and confer immunity to HIV (and potentially other unintended traits in the process). He went even further by implanting the embryos, and the first genetically modified babies were born in China in 2018. Hes work was universally condemned by the scientific community as sloppy and unethical. Yet, another scientist, this time in Russia, has since made public his intentions to use CRISPR to edit human embryos too.

The ethics quite clearly havent caught up to the science, and the tools themselves are still being sharpened, but its likely only a matter of time before scientists, researchers, and doctors begin more responsibly snipping out disease-causing genes and, perhaps, even splicing in beneficial ones.

George Church is anticipating that day.

George is probably the most prolific bioengineer of our time, Metcalfe said. [There] are fifty different alleles that hes tracking that are beneficial to humans. These variants include genes that help protect against cardiovascular disease and Alzheimers disease. Others may improve memory and learning and extend your telomeres.

But our design abilities wont be limited to existing genes, Metcalfe said. Scientists are assembling entirely new synthetic biological systems from scratch too.

Were writing DNA codeand weve been doing this for a whilebut were starting to get good at it, said Andrew Hessel, Humane Genomics CEO and nanotechnology/biotechnology faculty at Singularity University, in a talk following Metcalfes.

Hessel pointed to Twist Bioscience a synthetic biology company that went public in late 2018. Twist manufactures short custom sequences of DNA (oligos) at scale. Customers can design and order sequences and have them delivered by Fedex. With tools like this, synthetic biologists have begun creating synthetic enzymes and proteins, some of which have even proven themselves functionallike their natural siblingsin bacteria.

Scientists are thinking bigger too.

Craig Venter, already famed for his work sequencing the first human genome, announced the first reproducing synthetic bacteria back in 2010. He followed up with a streamlined minimal synthetic cell in 2016. Boasting the smallest known genome, it has no natural counterpart. Then this year, another group announced theyd made synthetic E. coli bacteria with a four million base-pair genomefour times longer than Venters 2010 achievementand using just 61 codons instead of 64. Currently, scientists are working with yeast to make the first synthetic eukaryotic cells.

The ultimate goal is writing whole human genomes from scratch, and Hessel cofounded Genome Project-write (GP-write) to convene the worlds top synthetic biologists to do just that.

There are obviously big hurdles that still need clearingincluding software that can make design more accurate and efficient and DNA synthesis tools that assemble longer base-pair sequencesand Hessels group recently published a paper outlining the challenges. Nonetheless, Hessel said the group doesnt think any of these will take more than a decade to solve.

Literally in 10 years weve gone from making proteins synthetically to making a eukaryote, he said. As soon as we can start making whole chromosomes, well, weve only got 23 of them. Its not going to take very long until you end up bumping up against the human genome.

The pace of change in biology and medicine has been swift, Metcalfe said.

Researchers discovered DNAs structure in 1953, the first IVF baby was born in 1978, and we met Dolly the sheep, the first cloned animal, in 1996.

In just the last two decades, scientists went from sequencing the human genome at great cost and effort to sequencing it for under $1,000 in a day. Now there are an estimated million-plus complete human genomes on the books.

Weve graduated from complex and costly gene editing tools to tools that can be sold in a kit for a few hundred bucks. Scientists are building genomes from scratch and booting them up.

The question is no longer whether well be able to design our own biologythe tools are already herethe question is can we handle the responsibility?

This technology is going to touch every business, every sector, every government, every person, Hessel said. This isnt a presentation for now, its the start of a conversation with all of you for the future.

Image Credit:gustavo centurion /Unsplash

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Your hatred of heart-healthy veggies could be genetic – WPMT FOX 43

If certain vegetables have always made you gag, you may be more than a picky eater. Instead, you might be what scientists call a super-taster: a person with a genetic predisposition to taste food differently.

Unfortunately, being a super-taster doesnt make everything taste better. In fact, it can do the opposite.

Super-tasters are extremely sensitive to bitterness, a common characteristic of many dark green, leafy veggies such as broccoli, cauliflower, cabbage and Brussels sprouts, to name a few.

The person who has that genetic propensity gets more of the sulfur flavor of, say, Brussels sprouts, especially if theyve been overcooked, said University of Connecticut professor Valerie Duffy, an expert in the study of food taste, preference and consumption.

So that [bitter] vegetable is disliked, and because people generalize, soon all vegetables are disliked, Duffy said. If you ask people, Do you like vegetables? They dont usually say, Oh yeah, I dont like this, but I like these others. People tend to either like vegetables or not.

In fact, people with the bitter gene are2.6 times more likely to eat fewer vegetables than people who donot have that gene, according to a new study presented Monday at the annual meeting of the American Heart Association.

We wanted to know if genetics affected the ability of people who need to eat heart-healthy foods from eating them, said study author Jennifer Smith, a registered nurse who is a postdoc in cardiovascular science at the University of Kentucky School of Medicine.

While we didnt see results in gene type for sodium, sugar or saturated fat, we did see a difference in vegetables, Smith said, adding that people with the gene tasted a ruin-your-day level of bitterness.

Our sense of taste relies on much more than a gene or two. Receptors on our taste buds are primed to respond to five basic flavors: salty, sweet, sour, bitter and umami, which is a savory flavor created by an amino acid called glutamate (think of mushrooms, soy sauce, broth and aged cheeses).

But its also smelling through the mouth and the touch, texture and temperature of the food, Duffy said. Its very difficult to separate out taste from the rest. So when any of us say the food tastes good, its a composite sensation that were reacting to.

Even our saliva can enter the mix, creating unique ways to experience food.

When we come to the table, we dont perceive the food flavor or the taste of food equally, Duffy said. Some people live in a pastel food world versus others who might live in a more vibrant, neon food world. It could explain some of the differences in our food preference.

While there are more than 25 different taste receptors in our mouth, one in particular has been highly researched: the TAS2R38, which has two variants called AVI and PAV.

About 50% of us inherit one of each, and while we can taste bitter and sweet, we are not especially sensitive to bitter foods.

Another 25% of us are called non-tasters because we received two copies of AVI. Non-tasters arent at all sensitive to bitterness; in fact food might actually be perceived as a bit sweeter.

The last 25% of us have two copies of PAV, which creates the extreme sensitivity to the bitterness some plants develop to keep animals from eating them.

When it comes to bitterness in the veggie family, the worst offenders tend to be cruciferous vegetables, such as broccoli, kale, bok choy, arugula, watercress, collards and cauliflower.

Thats too bad, because they are also full of fiber, low in calories and are nutrient powerhouses. Theyre packed with vitamins A and C and whats called phytonutrients, which are compounds that may help to lower inflammation.

Rejecting cruciferous or any type of vegetable is a problem for the growing waistline and health of America.

As we age as a population, vegetables are very important for helping us maintain our weight, providing all those wonderful nutrients to help us maintain our immune system and lower inflammation to prevent cancer, heart disease and more, Duffy said.

Food scientists are trying to develop ways to reduce the bitterness in veggies, in the hopes we can keep another generation of super-tasters from rejecting vegetables.

Theres been some success. In fact, the Brussels sprouts we eat today are much sweeter than those our parents or grandparents ate. Dutch growers in the 90s searched their seed archives for older, less bitter varieties, then cross-pollinated them with todays higher yielding varieties.

People who already reject vegetables might try to use various cooking methods that can mask the bitter taste.

Just because somebody carries the two copies of the bitter gene doesnt mean that they cant enjoy vegetables, Duffy said. Cooking techniques such as adding a little fat, a little bit of sweetness, strong flavors like garlic or roasting them in the oven, which brings out natural sweetness, can all enhance the overall flavor or taste of the vegetable and block the bitterness.

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Your hatred of heart-healthy veggies could be genetic - WPMT FOX 43

Editas Medicine Announces Third Quarter 2019 Results and Update – GlobeNewswire

Amended Celgene collaboration to focus on engineered alpha-beta T cell medicines with a $70 million payment to Editas Medicine

Appointed Judith R. Abrams, M.D., as Chief Medical Officer

EDIT-101 (AGN-151587) for LCA10 first patient dosing expected by early 2020

EDIT-301 for hemoglobinopathies in vivo pre-clinical data to be presented at ASH

CAMBRIDGE, Mass., Nov. 12, 2019 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today reported business highlights and financial results for the third quarter of 2019.

"Our momentum in 2019 remains strong in advancing our pipeline of in vivo CRISPR and engineered cell medicines," said Cynthia Collins, Chief Executive Officer of Editas Medicine. We announced this morning an amended agreement with Celgene to further expand and accelerate our oncology pipeline. In hemoglobinopathies, we look forward to presenting in vivo pre-clinical data for EDIT-301 at ASH that supports its potential as a best-in-class medicine. Finally, we eagerly anticipate first patient dosing with EDIT-101 for LCA10 in the coming months.

Recent Achievements and OutlookIn VivoCRISPR Medicines

Engineered Cell Medicines

Corporate

Upcoming Events

Editas Medicine will participate in the following investor events:

Editas Medicine will present pre-clinical data for EDIT-301 to address sickle cell disease and beta-thalassemia in at the 61st American Society of Hematology Annual Meeting & Exposition. Details are as follows:

Abstract Number: 4636Title: EDIT-301: An Experimental Autologous Cell Therapy Comprising Cas12a-RNP Modified mPB-CD34+ Cells for the Potential Treatment of SCDPresenter: Edouard De Dreuzy, Ph.D.Session: 801. Gene Therapy and Transfer: Poster III Time: Monday, December 9, 2019: 6:00 PM-8:00 PMLocation: Hall B, Orange County Convention Center, Orlando, FL

Third Quarter 2019 Financial Results

Cash, cash equivalents, and marketable securities at September 30, 2019, were $332.6 million, compared to $369.0 million at December 31, 2018. The $36.4 million decrease was primarily attributable to operating and capital expenses related to our on-going preclinical and clinical activities, patent costs and license fees, and employee-related costs, partially offset by $42.1 million in proceeds from financing activities.

For the three months ended September 30, 2019, net loss was $32.9 million, or $0.66 per share, compared to $15.2 million, or $0.32 per share, for the same period in 2018.

Conference Call

The Editas Medicine management team will host a conference call and webcast today at 8:00 a.m. ET to provide and discuss a corporate update and financial results for the third quarter of 2019. To access the call, please dial 844-348-3801 (domestic) or 213-358-0955 (international) and provide the passcode 6577216. A live webcast of the call will be available on the Investors & Media section of the Editas Medicine website at http://www.editasmedicine.com and a replay will be available approximately two hours after its completion.

About Editas MedicineAs a leading genome editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. For the latest information and scientific presentations, please visit http://www.editasmedicine.com.

About EDIT-101 (AGN-151587)EDIT-101 is a CRISPR-based experimental medicine under investigation for the treatment of Leber congenital amaurosis 10 (LCA10). EDIT-101 is administered via a subretinal injection to reach and deliver the gene editing machinery directly to photoreceptor cells.

About Leber Congenital AmaurosisLeber congenital amaurosis, or LCA, is a group of inherited retinal degenerative disorders caused by mutations in at least 18 different genes. It is the most common cause of inherited childhood blindness, with an incidence of two to three per 100,000 live births worldwide. Symptoms of LCA appear within the first years of life, resulting in significant vision loss and potentially blindness. The most common form of the disease, LCA10, is a monogenic disorder caused by mutations in the CEP290 gene and is the cause of disease in approximately 2030 percent of all LCA patients.

About the Editas Medicine-Allergan AllianceIn March 2017, Editas Medicine and Allergan Pharmaceuticals International Limited (Allergan) entered a strategic alliance and option agreement under which Allergan received exclusive access and the option to license up to five of Editas Medicines genome editing programs for ocular diseases, including EDIT-101 (AGN-151587). Under the terms of the agreement, Allergan is responsible for development and commercialization of optioned products, subject to Editas Medicines option to co-develop and share equally in the profits and losses of two optioned products in the United States. In August 2018, Allergan exercised its option to develop and commercialize EDIT-101 globally for the treatment of LCA10. Additionally, Editas Medicine exercised its option to co-develop and share equally in the profits and losses from EDIT-101 in the United States. Editas Medicine is also eligible to receive development and commercial milestones, as well as royalty payments on a per-program basis. The agreement covers a range of first-in-class ocular programs targeting serious, vision-threatening diseases based on Editas Medicines unparalleled CRISPR genome editing platform, including CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a).

Forward-Looking StatementsThis press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. The words anticipate, believe, continue, could, estimate, expect, intend, may, plan, potential, predict, project, target, should, would, and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include statements regarding the Companys plans with respect to the Brilliance Phase 1/2 clinical trial for EDIT-101 (AGN-151587), including the Companys expectations regarding the timing of dosing a patient by early 2020. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: uncertainties inherent in the initiation and completion of pre-clinical studies and clinical trials and clinical development of the Companys product candidates; availability and timing of results from pre-clinical studies and clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products and availability of funding sufficient for the Companys foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption Risk Factors included in the Companys most recent Quarterly Report on Form 10-Q, which is on file with the Securities and Exchange Commission, and in other filings that the Company may make with the Securities and Exchange Commission in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

Investor ContactMark Mullikin(617) 401-9083mark.mullikin@editasmed.com

Media ContactCristi Barnett(617) 401-0113cristi.barnett@editasmed.com

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Editas Medicine Announces Third Quarter 2019 Results and Update - GlobeNewswire

Gene targets for obesity and wildfire research: News from the College | Imperial News – Imperial College London

Heres a batch of fresh news and announcements from across Imperial.

From a study showing a genetic link for obesity, to a new centre for wildfire research, here is some quick-read news from across the College.

An international team has discovered a new genetic link for a type of obesity which affects pathways in the brain as well as in the pancreas.

Caused by mutations in a single gene called MRAP2, the condition is associated with excessive hunger and linked to early onset diabetes and high blood pressure.

Professor Philippe Froguel, who worked with French researchers in Lille on the discovery, hopes the findings could lead to new treatments targeting the MRAP2 protein. He said: Discoveries such as these could help to tackle genetic forms of obesity. Finding the genetic basis is the key to targeting excessive hunger.

Froguels team previously identified the MC4R gene and a treatment to activate the protein and affect appetite. The treatment is expected to become available from next year.

Read more in Nature Medicine: Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

When it comes to asthma, neutrophilsmay not be the bad guys people thought they were.

Severe asthma is caused, in part, by inflammation of the branching airways inside the lungs which makes it hard to breathe. White blood cells called neutrophils are a major component of this inflammation, and researchers previously thought these cells were driving much of the lung damage and ensuing symptoms.

But new research fromDr Robert SnelgroveandDr Dhiren Patel, from Imperials National Heart and Lung Institute,hasfound that neutrophils are not all bad in the context of asthma. They show targeting neutrophils can also have a negative effect, as they have a regulatory role over other inflammatory cells in the lung.

Read the full paper in Science Immunology: Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocytedendritic cell antigen presentation

Professor Ricardo Martinez-Botas, from the Department of Mechanical Engineering, has received an Honorary Doctorate in Engineering from Universiti Teknologi Malaysia (UTM).

Professor Martinez-Botas is the co-Director of UTMs Centre for Low Carbon Transport (LoCARtic) and has supervised more than ten PhD students from UTM and other institutions in Malaysia.

In 2018, the Prime Minister of Malaysia Tun Dr Mahathir bin Mohamad visited Imperial and toured Professor Martinez-Botass Turbo Group lab, learning about the latest developments in low-carbon transport and electric motors, as well as major collaborations with UTM.

Matoha Instrumentation, founded by Imperial scientists and entrepreneurs, has won an Institute of Physics Business Start-Up Award.

The company make technologies that quickly and cheaply analyse the chemical composition of materials that visually look the same, allowing them to be more easily sorted for recycling. They have made two platforms: one that identifies and analyses plastics, and one that works with fabrics.

The technology uses a combination of near-infrared spectroscopy and machine-learning algorithms to continuously improve performance. The small and low-cost nature of the technology means it can also be used where larger, automatic detectors are not feasible, instead providing a better pair of eyes to manual sorters. The team behind Matoha Instrumentation previously won the Faculty of Natural Sciences Make-A-Difference competition.

Read more on the Institute of Physics website

The Equality, Diversity and Inclusion Centre marked the end of Black History Month and six years of the IMPACT talent development programme for Black, Asian and Minority Ethnic (BAME) staff with a special reunion event. Delegates and mentors, old and new, gathered at the event to reflect on and celebrate their time on the programme.

Gabriella Gordon-Kerr, Equality, Diversity and Inclusion Coordinator, has been at the helm of the IMPACT programme since it started in 2014. She said: It was great to gather our delegates and mentors in one room, and to reflect on the success of the IMPACT programme. At our reunion event, we looked at the history of the programme and heard stories of progression from delegates.

We asked delegates to sign a guest book on the day, and one of the quotes that resonated with us said: IMPACT has left an ever-lasting impact on my life in more ways than one. Heres hoping to another great six years.

BBC Security Correspondent Gordon Corera presented the 10th Vincent Briscoe Lecture of Imperials Institute for Security Science and Technology this week.

He spoke of the intertwining history of technology and espionage over the last century, from the most classified heart of the national security state. From Bletchley Park through the Cold War to Google and Huawei he explored how data, encryption and computers transformed what we think of as secret and what this means for us.

This marks the tenth anniversary of the lecture, which was named in honour of Professor Vincent Briscoe, a distinguished inorganic chemist at Imperials Department of Chemistry.

Dr Jackie Bell has won the Rising Star Award from WISE a campaign that promotes the work of women in STEM.

The annual awards recognise inspiring individuals who actively promote these subjects to girls and women. Dedicated to raising aspirations and changing peoples beliefs that science isnt for them, Dr Bell has given talks to schools and community groups across the UK, and helps Imperial and other institutions develop inclusive community outreach approaches.

Jackie is currently developing the Department of Computings outreach strategy, committing to at least 50 per cent female participation for all activities. Jackie said: Im a strong supporter of the WISE Campaign and all that is being done to achieve gender balance. To have my work recognised like this is an honour and winning the Rising Star award has given me a greater platform to bring about positive change.

Imperial held the launch of a new research centre studying the science and impact of wildfires. Speakers from the Leverhulme Centre for Wildfires, Environment and Society were joined by Marc Castellnou, a Strategic Fire Analyst working with Bombers de Catalunya (Firefighters of Catalonia), who warned that warm and wet winters, followed by extremely hot summers are a perfect storm for the most dangerous wildfires.

Historically common in Mediterranean countries, evidence shows these conditions have arrived in the United Kingdom, Ireland and Scandinavia as a result of climate change. The Centres new Director, Imperials Professor Colin Prentice, said, We need a better understanding of how and why wildfires occur, knowledge to make seasonal forecasts, and an urgent need to understand how to live with wildfires.

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Gene targets for obesity and wildfire research: News from the College | Imperial News - Imperial College London

Hate The Taste Of Vegetables? Your Genes May Be To Blame, Study Finds – Study Finds

LEXINGTON, Ky. If youve just never been able to wrap your mind around how people eat vegetables like broccoli or brussels sprouts and actually enjoy the taste, it turns out you may be experiencing an entirely different taste when you bite into a forkful of greens. According to a new set of preliminary research, some people carry a specific gene that makes certain foods, including most heart healthy vegetables, taste especially bitter.

Those carrying this taste gene are much more likely to have a harder time incorporating vegetables into their daily diets.

Your genetics affect the way you taste, and taste is an important factor in food choice, says study author Jennifer L. Smith, a postdoctoral fellow in cardiovascular science at the University of Kentucky School of Medicine in Lexington, in a release. You have to consider how things taste if you really want your patient to follow nutrition guidelines.

Every single human is born with two copies of a taste gene called TAS2R38.However, some people inherit two versions of the gene called AVI,while others inherit just one copy of AVI and another variation of the gene called PAV.People with two AVI genes arent particularly sensitive to bitter tastes from certain compounds, but those with one PAV variant experience mild bitter sensations from certain foods.

Then, there is another group of people who inherit two PAV variant genes. This group, often referred to as super tasters, find certain foods extremely bitter.

Were talking a ruin-your-day level of bitter when they tasted the test compound. These people are likely to find broccoli, brussels sprouts and cabbage unpleasantly bitter; and they may also react negatively to dark chocolate, coffee and sometimes beer, Smith explains.

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It is estimated that roughly 50% of humans inherit both a PAV and AVI gene variant, while 25% are born with two PAV variants, and another 25% inherit two AVI variants.

Researchers went through food-questionnaire responses from 175 participants, and found that people with two copies of the PAV form of the gene (super tasters) were over two and a half times more likely to be in the bottom half of participants regarding number of vegetables consumed. The average age of the participant group was 52, and over 70% were females.

Interestingly, bitter sensitivity did not seem to influence the amount of salt, sugar, or fat that participants were eating.

We thought they might take in more sugar and salt as flavor enhancers to offset the bitter taste of other foods, but that wasnt the case. Down the road we hope we can use genetic information to figure out which vegetables people may be better able to accept and to find out which spices appeal to super tasters so we can make it easier for them to eat more vegetables, Smith concludes.

The study is set to be presented at the American Heart Associations Scientific Sessions 2019.

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Hate The Taste Of Vegetables? Your Genes May Be To Blame, Study Finds - Study Finds

‘Science is a contact sport’: What one U of T researcher learned in the lab of Nobel laureate William Kaelin – News@UofT

When University of Toronto Professor Michael Ohh was scouting postdoctoral positions at Harvard Medical School in the mid-1990s, a group of Canadians that often gathered to talk science told him to check out the molecular oncology floor at the Dana-Farber Cancer Institute, run by legendary virologist David Livingston.

It turned out to be good advice.

Ohh met with three young investigators Livingston had trained and hired, including the clinician-scientist William Kaelin Jr. The floor was full of bright and driven people, and the electricity in the air was palpable, recalls Ohh, now a professor of laboratory medicine and pathobiologyand of biochemistry at U of T.

Ohh spent the next five years in Kaelins lab and co-authored several papers on how cells respond to changes in oxygen levels research that contributed to Kaelin being awarded the 2019 Nobel Prize in Physiology or Medicine.

The work also set the stage for Ohhs career as an independent scientist in Toronto, and it continues to bear fruit and hold promise for treatments of cancer and other diseases.

One of the most significant things I learned in Bills lab was a rigorous approach to science, says Ohh. He really wanted you to nail the mechanism with a series of elegant experiments and he understood that process is highly competitive with other labs. He often said, Science is a contact sport.

Ohh calls his time in Kaelins lab a tour of duty unbearably stressful at times, but balanced by the excitement of doing fascinating science with talented people.

Kaelins lab was focused on three tumour suppressor genes. Two were well known, but the third was a newly discovered gene called VHL that had been shown to cause von Hippel-Lindau syndrome, a rare hereditary disorder in which patients develop multiple benign and cancerous tumours.

Only a handful of labs in the world studied VHL at the time and virtually nothing was known about its function. We tried a guilt-by-association approach, looking for proteins with which VHL interacted in the hope that these might shed clues to VHL function, says Ohh.

By the late 1990s, they had found several and determined that those proteins are part of a larger complex that likely targets other proteins for destruction.

They showed that without a functional VHL protein, these complexes are unable to degrade another protein called hypoxia-inducible factor (HIF), which in turn spurs tumour cell survival and growth even in low-oxygen microenvironments.

The mechanism at play in von Hippel-Lindau syndrome, in other words, also impacts how all cells sense and adapt to oxygen deprivation. The worlds of hypoxia and VHL collided in that discovery, says Ohh.

Researchers have since developed ways to control how cells sense and adapt to changes in oxygen, and are applying those findings for various conditions. A drug based on this approach is in clinical trial for various cancer types, and the findings also look promising in pre-clinical research for cardiovascular disease and anemia.

Ohhs lab in Toronto has just figured out why certain people with mutations in another HIF gene get cancer and/or polycythemia (an excess of red blood cells). Recent clinical reports have detailed the plight of people with this mutation, and clinicians are now asking Ohhs lab if they can help predict what disease their patients will eventually develop, so they can better monitor their patients for these conditions.

Early detection is critical for outcomes in cancer treatment, so this is useful, highly personalized medicine, says Ohh. And its an extension of the work we did 20 years ago, which is gratifying.

Ohh and his lab are also looking at evolutionary aspects of this molecular pathway. They are studying evolutionary diversions of the pathway among different animals over millions of years to see which genetic sequences and motifs are conserved.

Insights into these diversions could offer ways to understand the precise mechanisms and critical regions of HIF and VHL by which cells better respond to oxygen fluctuations.

Great science isnt the only product of the Kaelin lab. Ohh met his wife Meredith Irwin there when she was a research trainee, and they have been together for two decades. Irwin is a professor of pediatrics, medical biophysics and laboratory medicine and pathobiology at U of T, as well as a clinician-scientist at The Hospital for Sick Children.

Irwin was born and raised in New York, studied at the Massachusetts Institute of Technology and Harvard, and trained at Boston Childrens Hospital and Dana-Farber for more than a decade.

The couple travelled to Boston for Kaelins 60th birthday two years ago. They asked us to give talks, and afterward Bill made a comment about me stealing an American to Canada, says Ohh. We really are very happy here in Toronto.

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'Science is a contact sport': What one U of T researcher learned in the lab of Nobel laureate William Kaelin - News@UofT

Hate Karela, Palak & Tinda? Your Genes May Be The Reason, Says Study – Storypick

Getting an earful from mum everyday for not eating green vegetables is a routine. Because most of us dont like eating vegetables and we keep thinking of excuses to escape the wrath of moms over veggies, of course.

As per the experts from the University of Kentucky School of Medicine, every person inherits two copies of a taste gene called TAS2R38 which encodes a protein that allows us to taste bitterness. Those who inherit two copies of a variant of this gene called AVI are not sensitive to bitter tastes while those who inherit one copy of AVI and another called PAV perceive bitter tastes.

So that [bitter] vegetable is disliked, and because people generalize, soon all vegetables are disliked, Duffy said. If you ask people, Do you like vegetables? They dont usually say, Oh yeah, I dont like this, but I like these others. People tend to either like vegetables or not, she added.

So, the next time your mother scolds you for not eating greenvegetables, you could always blame it on genes or on your forefathers! * wink *

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Hate Karela, Palak & Tinda? Your Genes May Be The Reason, Says Study - Storypick

Gene Editing Tool was Modified to Improve Therapies for HIV – Science Times

(Photo : pexels)

The researchers from the City of Hope may have found a way to sharpen the cheapest, fastest, and most accurate gene-editing tool called the CRISPR-Cas9 so that it can successfully cut out undesirable genetic information. This cutting ability was improved so that one day, experts can fast-trackpotential therapiesfor sickle cell disease, HIV, and other immune conditions.

What is the CRISPR-Cas9 design

Tristan Scott, Ph.D., lead author of the study and a staff research scientist at City of Hope's Center for Gene Therapy, said that the CRISPR-Cas9 design might be the difference between trying to cut a rib eye steak with a butter knife versus cutting it with a steak knife. Other scientists have tried to improve CRISPR cutting through chemical modifications, but that is an expensive process, and it is like diamond-coating a blade. Scientists have designed a better pair of scissors that people can buy easily anywhere.

Thestudythat was done by Dr. Scott and his team was published in Scientific Reports, and it is the first time scientists have systematically gone through the guide RNA sequence to change it and to improve CRISPR-Cas9 technology. A patent application was filed at The Kevin Morris Lab at City of Hope, claiming this improved CRISPR-Cas9 design, which could result in a doubling of activity, but the exact amount was dependent on the target site.

Theeffects of this CRISPR-Cas9 designis downstream as it has more "clean" results in mouse model and cell experiments aimed at making new therapies because the target that was knocked out was more successfully removed. More results could quicken new therapies from the laboratory to patients' bedsides. The therapeutic product should have successful cuts, which could mean that an improved therapy is on the way, but further research is still needed. The exact ways and process of why this change to the CRISPR system improves gene editing still needs to be determined.

Experiments through nanotechnology

The researchers of the study experimented on cells by making certain changes to the tracrRNA or trans-activatingCRISPR RNAwhich they got from Streptococcuspyogenesbacteria, and it is a part of the components that are used to guide the genetic scissors, also known as Cas 9, to the right gene sequence. StreptococcuspyogenesCas9 is the most widely used genetic scissor. Dr. Scott and his team used an RNA protein system because it gives an increase of activity that disappears about 12 hours after being introduced into the cell, which means that there is a decreased chance of accidentally editing the human genelater after the fix has been made.

Scientists found that the modified tracrRNA improved the overall silencing of certain genes by increasing desirable mutations in the genetic material. In this study, the target was an essential component of HIV's lifecycle, the protein CCR5 on immune CD4+ T-cellsa current target in clinical trials seeking to re-create a person's immune system so they can be resistant to HIV. The modified tracrRNA had improved the overall cutting at this site and inactivation of CCR5, and hopefully, that will translate into better protection for the immune system.

The new tracrRNA design is better at improving the activity at the HBB gene and the BCL11A site. The HBB gene, which is responsible for producing beta-globin that is located inside red blood cells, and BCL11A, which may function as a leukemia disease gene, are targeted by the tracrRNA in order to make different therapies for HIV, which is known as a blood disease that does not have any known cure yet.

Dr. Scott stated that if the line of research remains consistent, and they can dependably sharpen the genetic scissor, the result could eventually be new or improved genetic therapies. He also said that his team is at the beginning of a long scientific process.

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Gene Editing Tool was Modified to Improve Therapies for HIV - Science Times

In the long run, we must live – Economic Times

By Hardayal Singh

John Maynard Keynes did a great disservice to future generations when he said that in the long run, we are all dead. Inadvertently, he may have shifted the discourse in public policy towards ad hocism at the expense of long-term outcomes. The consequence of this shift, particularly in India, has been disastrous.

The recent health emergency in Delhi-National Capital Region (NCR) is one manifestation of such systemic myopia. One of the origins of this crisis springs from surplus rice produced in Haryana and Punjab during the kharif (autumn) season.

Currently, the buffer stock is 27.2 million tonnes against a national requirement of 10.25 million tonnes. Rice is a water guzzler. Production of one tonne of rice requires nearly 7,000 tonnes of water. So, if GoI is compelled to export 12 million tonnesof rice out of its current surplus, it is actually exporting 84 billion tonnes of water. The only reason farmers produce this crop is because they are supplied free water and electricity, and are assured of a minimum support price (MSP).

To conserve scarce groundwater resources, farmers in these two states are statutorily prevented from planting paddy till mid-June every year. So, they can harvest rice only in late October-early November.

The only way they can prepare their fields for the next rabi planting in November is to burn the stubble emanating from the earlier crop.

When wind speeds are low, this creates a poisonous smog. Beyond band-aid solutions, the only way out is to create incentives to nudge farmers away from rice towards crops such as fruit, vegetables and maize. Besides saving scarce water, this would reduce air pollution in Delhi-NCR by about 30%. Augmenting maize production would also help India cope with its ethanol scarcity for fuel purposes.

In the 1980s, GoI resorted to reckless borrowing to finance development. As a result, the combined fiscal deficit of the central and state governments climbed from 6.3% of GDP in FY1982 to 9.4% of GDP in FY1991. By that time, a full-fledged forex crisis broke out, since shortterm external commercial borrowings rose to 146.5% of forex reserves. Timely loans of about $3.4 billion from the International Monetary Fund (IMF), and friendly governments like Japan and Germany, prevented the economy from plunging into chaos.

Called upon to carry out economic reforms by IMF, GoI did the barest minimum required of it. It reformed the consumer markets. But out of fear of a popular backlash, it failed to reform the public sector, education sector and product (land, labour and capital) markets. The consequences of this are being felt even today.

Internationally, too, most governments often do what is expedient at the cost of what is right. In the future, the economic and social costs of such failures are likely to be much greater. As new advances in molecular biology, artificial intelligence (AI), nanotechnology, IT and Internet of Things (IoT) shape our lives, the rate of technological and social change will be much faster. As a result, considerable expertise will be required to anticipate and deal with the problems thrown up by a new world. Unemployment will assume anew dimension with increasingautomation. Growth alone will not be able to create jobs. People will have to update their skills through their lives to remain relevant.

Would it not be better if we frame policies that anticipate long-term developments, rather than react to crises when they descend on us? In the case of north Indian cities and towns, seasonally each year.

The writer was chief commissioner, income-tax

DISCLAIMER : Views expressed above are the author's own.

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In the long run, we must live - Economic Times

Carbon Fibre Application to Biomaterials Market size with Global Investment and analysis of Leading business players : ACS Material, eSpin…

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Carbon Fibre Application to Biomaterials Market size with Global Investment and analysis of Leading business players : ACS Material, eSpin...

Dassault Systmes’ Science in The Age of Experience Event Brings Together Some of the Best and – ARC Viewpoints

Summary

Dassault Systmes typically holds its annual Science in The Age of Experience in the Boston area. This is both because the companys North American headquarters is in Waltham, Mass. and because Boston is a major global center of education, technology, and science. This years conference was held at the Harvard Medical School, a very appropriate forum for an event that would feature how science affects so many aspects of our lives.

The focus of this years event focused on three areas: science for medical, life sciences, and bionics; science for mitigating climate change; and scientific innovation for the future. The latter included some forecasts and predictions on what we can expect to make significant impacts on society at large.

The speakers included a very distinguished list of scientists whose fields included theoretical physics, human body bionics, computer science (quantum computing), carbon-capture technologies, advanced molecular chemistry for batteries, and material science for new product innovation.

Bernard Charles, Vice Chairman and CEO of Dassault Systmes introduced the event. Mr. Charles said that the company has been transforming from being primarily a product lifecycle management (PLM)-focused company to a science-focused company for some time now. Today, Dassault Systmes multiple 3DS brands are dedicated to scientific research and product development. The companys advanced 3D simulation tools like SIMULIA, BIOVIA, and GEOVIA were all represented in the various areas of scientific research presented at the event. Clearly, Bernard is saying that simulation is at the heart of everything 3DS is doing: simulation across multiple spectrums of the physical world is the implementation of the 3DEXPERIENCE.

The keynote speaker for the first day was Lisa Randall, Professor of Theoretical Physics at Harvard University. Dr. Randall is an expert on the origins of the universe, gravitational waves, and dark matter. She focused on how 3D simulation tools help physicists simulate cosmological events on the far edges of the known universe to better understand how the universe was formed. She has made ground-breaking discoveries in gravitational waves and dark matter formed from the collision of gigantic black holes in the very beginning of the universe billions of years ago.

Dr. Randall presented an interesting take on how theoretical physicists make discoveries about the known universe. She noted that scale matters when probing the origins of the universe and that humans can lose the perspective of just how enormous the ever-expanding universe is from our tiny island earth. As a physicist, Dr. Randall maintains that what one observes depends on where you are and intuition is guided by what we can observe. She points out that humans have only discovered a very rudimentary part of the laws of physics and what we have yet to discover will change humankind.

Hugh Herr, Professor of Robotics and Human Bionics from MIT research labs, presented the second keynote on The New Era of Extreme Bionics. Dr. Herr, who as a young man had both legs amputated below the knee due to severe frostbite suffered in high altitude climbing, walked briskly onto the stage on his bionic legs. These were his own invention and development based on advanced robotics and direct feedback from surrounding muscles using computerized sensors. His movements were completely natural and human like without any sign of a mechanized effect while walking, jumping, or other natural movements.

Using SOLIDWORKS, Dr. Herr developed a new robotic, computerized prosthesis. This is attached to living muscle that works from direct brain commands. This enables the wearer to use his or her own natural brain sensory reactions to control movements in the foot and leg protheses. He prototyped the first prosthesis on a friend that lost a leg in a climbing accident. This person was able to return to the actual wall where he fell and finish the climb with his bionic leg. Dr. Herr received a standing ovation from the audience at the conclusion of his presentation.

There were presentations from researchers from the pharma and life sciences industries demonstrating how they use 3DS BIOVIA molecular compounding simulation to develop new drugs in a matter of months, rather than years.

Dr. Jennifer Wilcox, Professor of Physical Chemistry at Worchester Polytech presented on the latest technology used to capture CO2 from the air and from industries. She illustrated a very quantified view of the technology of CO2 capture, multiple forms of storing and using the CO2, and the cost of the various processes.

Dr. Michio Kaku, theoretical physicist, co-founder of string theory, renowned futurist, and author of many books on the subject presented on the future of science and made several scientific forecasts. Dr. Kaku presented a look beyond the current third wave of technology (age of digitalization) and looked at the fourth and fifth waves of the future. The fourth wave will be the molecular wave spawned by pervasive use of AI, nanotechnology, and simulation at the molecular level. The fifth wave will be the physical world (physics) at the atomic level where we will finally realize fusion-powered energy and move to pervasive quantum computing. Also in the fifth wave, the Internet as we know it will be replaced by the Brain Net, where humans will be connected at the level of thought and emotions.

At the conclusion of the presentations, the attendees were bused to the MIT research and development labs for a tour of current projects and technologies being developed. Neil Gershfeld, MIT director of the labs, conducted our group through the Atoms and Bits labs where MIT graduate research fellows are conducting some very fascinating and interesting projects. The labs are referred to as the "maker labs" because projects reflect research focused on real-world applications. The labs are funded by a combination of industry, academia, and government.

We saw several nanotechnology projects. One focused on using origami mathematics to develop ultra-lightweight and super-strong folded structures for the aerospace industry. These experimental structures enabled the design of new aerodynamically adaptable wings that could change shape in flight to optimize aerodynamics. Other projects were around 3D printing for cellular-level nanostructures. Another was the development of small builder-bots that were a part of the structures that they built autonomously, piece by piece.

The Science in The Age of Experience event by Dassault Systmes has become an annual gathering of some of the best and brightest scientists and researchers in their respective fields. They present their discoveries, inventions and scientific breakthroughs and an examination of some of the latest scientific achievements that impact industry, business, and society at large. This conference showcases several of the 3DS brands that enable scientists and researchers to simulate, discover, and develop cutting edge processes, products, and technologies, and brings together some of the best scientists in their fields, enabling Dassault Systmes to acknowledge and applaud their singular achievements.

ARC Advisory Group clients can view the complete report at ARC Client Portal

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Keywords: Scientific Innovation, SIMULIA, SOLIDWORKS, BIOVIA, GEOVIA, Simulation, Bionics, Life Sciences, Future of Science, Climate Change, ARC Advisory Group.

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Dassault Systmes' Science in The Age of Experience Event Brings Together Some of the Best and - ARC Viewpoints

A Curator Boyfriend is the Hottest Accessory for 2020 – ELLE.com

With JLaws nuptials to art-world cutie Cooke Maroney behind her, and the recent announcement of Jenny Slates engagement to Ben Shattuck, a new boyfriend paradigm has emerged, inspiring us all to spend more time gallery hopping, and less time at the bars.

Unlike archetypes of boyfriends past the Investment Banker, the Silicon Valley Tech Guy, the Artist/Freelance Videographer/Professional Plant Owner the Curator is a breath of fresh air, presenting a bounty of attractive qualities that challenge existing dating-pool stereotypes.

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The Curator is endowed with qualities that include, but are not limited to: the business savvy to navigate the high-stakes art market, enough sensitivity to appreciate the latest Marina Abromovic performance piece, and the occasional invite to party on a boat with Stavros Niarchos. Theyre well-read, worldly and engaged in shaping critical dialogues of our times. The kind of guy you can discuss post-humanism with over pizza, who comments on the decor while ordering you a cab but letting you split the bill.

Were about to enter a new decade, and being self-aware and socially conscious has never been more attractive. Someone who can point to a favorite Louise Bourgeois sculpture or be brought to tears looking at an El Anatsui assemblage is not only in touch with his emotions but also cares about wider social, geopolitical and cultural issues. A Curator may still ghost you, but its probably because hes doing something legitimately interesting with his time, like scouting in the foothills of the Himalayas.

A Curator may still ghost you, but its probably because hes doing something legitimately interesting with his time, like scouting in the foothills of the Himalayas.

Cassidy Sparrow

Yes, many guys who are not Curators also fit this description: Artists/Musicians, Architects, Professors, Writers, Furniture Makers, Doctors, Generally Cool Sensitive Dudes. But unlike the Curator, these careers have the potential to be solitary and isolating.

Getty Images

A Curator enjoys engaging with people on a daily basis resulting in a much more social (read: fun! well-adjusted!) dating prospect.

Ultimately, a Curators heightened attunement to art has a trickle down effect into what is the most differentiating and attractive quality of all taste. Good taste is what most likely allowed a 21-year-old Vito Schnabel (the OG Cute Curator of the early 00s) to date the much older Demi Moore, later Heidi Klum, and most recently Amber Heard. Good taste doesnt listen to Chris Brown, leave half-drunken six packs around your apartment or wear bad shoes. Sorry to that man, and every guy who does this.

Marco Secchi

Venturelli

And ok, yeah - did we mention theyre just hot?

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A Curator Boyfriend is the Hottest Accessory for 2020 - ELLE.com

These Staunton residents struggled to find a secular community so they made their own – The News Leader

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Tom Cardarella (left), Charles Phinizy (center) and Lou Boden (right) gather for a meeting of the Staunton Secular Humanists at Crucible Coffee on Nov. 3, 2019.(Photo: Rilyn Eischens/The News Leader)

STAUNTON Kim Newton spent Thanksgiving weekend last year constructing a display for Staunton's annual Celebration of Holiday Lights. She painted the Earth on a huge sign, strung lights around it and set it up at Gypsy Hill Park with a few friends.

Newton was gladto see heridentity as a secular humanist represented in the festive display andhoped the sign would raise awareness of the newly established group Staunton Secular Humanists. Several people stopped to ask questions about humanism and group meetings, which Newton took as a positivesign.

Then in December, the group was distressed to see the display's lightsunplugged several times. Member Charles Phinizy started driving through Gypsy HillPark every night to see if it was still lit.

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Undeterred by the tension, Staunton Secular Humanistsis gearing up to post another holiday displayand to host its second winter solstice celebration next month. The group has grown since last year and now holds weekly meetings for residents toenjoy the company and communityreligious people might find at churches, mosques and synagogues.

"It's important to me that non-religious identities have equal treatment and are seen and treated with respect in our community," Newton said. "That was a big part of the impetus for wanting to have a public group."

The Staunton Secular Humanists posted their first display in Staunton's Celebration of Lights in 2018.(Photo: Courtesy of Kim Newton)

The share of United States adults who say they aren't affiliated with any religion has increased in recent years, and the percentage of those who identify as Christian has declined. The trend is especially pronounced among people ages 23 to 38, of whom 40% identify as religiously unaffiliated, according to Pew Research Center.

Newton identifies as a secular humanist a philosophy that, broadly, teaches theuse of compassion and critical thinking to do good but the Staunton group is intended to serve all religiously unaffiliated, secular and spiritual residents. Newton and Phinizy explained thatnon-Christians can often feel isolated or even ostracized intraditional regions like the Shenandoah Valley.

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Phinizy said he's experienced this ostracism firsthand. Before he moved to the Valley, many of his coworkers stopped socializing with him and his family when they learned he wasn't Christian, he said. He no longer advertises his identity at work and was eager to learn about the brand-new Staunton group last winter.

"Anything outside of the norm of traditional Christianity is stigmatized," Newton said. "Being more public with your secular identity, being more public with the ideals that you hold and the values that you hold, I think, is actually a good way to help overcome [stereotypes]."

For the last several months, the group has held meetings at Staunton cafesevery Sunday morning. The number of attendees varies week to week, but at least a handful always come to sip coffee and chat, Newton and Phinizy said. The group rarely discusses religion newcomers are more likely to find members talking about weekend plans, hobbies and issues they're passionate about.

More: A tale of two cities: How Staunton and a small city in North Macedonia became friends

Going forward, members plan to shift the group's focus toward community service. They'd also like to see it expand and reachmore local families. Newton, a new mom, said they'vehoped to find a child-friendly space for meetingsbut struggle to find a facility willing to host the secular organization.

"A lot of families get that community support they need from their church, but not everyone has that, and not everyone wants that type of community, so it's important to me to try to make that space for kids and for my kid," Newton said.

On a recent bright Sunday morning, Phinizy and local artists Tom Cardarella and Lou Boden camped out at the end of a long table in Crucible Coffee.They drank hot coffee from white to-go cups and talked about the Staunton art scene, among other topics.

Boden, a retired interfaith minister who said he believes strongly in God,explained thatthe prospect of good conversation with open-minded people drew him to the group.

"No matter what your belief or opinion, you're welcome as long as you respect everyone else's beliefs, and that's what interests me," Boden said.

More information about the group is available on its Facebook page.

More: Chaplain hopes to create culture of mindfulness at Stuart Hall, one breath at a time

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These Staunton residents struggled to find a secular community so they made their own - The News Leader

Another Europe is Possible – Resilience

As harsh austerity and xenophobic nationalism fester in Europe, Yanis Varoufakis discusses his antidote with Tellus Senior Fellow Allen White.

What inspired your career trajectory from academic economist to prominent supranational activist?

I went into politics because of the financial crisis of 2008. Had financial capitalism not imploded, I would have happily continued my quite obscure academic work at some university. The chain reaction of economic crises, financial bailouts, and the rise of what I call the Nationalist International that almost broke financial capitalism, and brought Greece severe hardship, had a profound impact on me.

In the early to mid-2000s, I was beginning to feel that a crash was approaching. I could see that global financial imbalances were growing exponentially and that our generation or the next would be hampered by a systemic crisis.

I left my cocoon writing about mathematical economics and moved from Sydney to Athens at the time Greece was becoming insolvent. I began writing about the current situation and appearing on TV, warning against covering up insolvency with bailouts. Through these appearances as well as writing about governments role in averting the impending crisis, I drifted into politics.

The second transition, from government to activism, was much simpler. Restructuring Greeces debt was my top priority as Minister of Finance. The moment the Prime Minister surrendered to the austerity demands of the European Commission and accepted another loan without debt restructuring, resignation became the easiest decision of my life. Once I resigned, I was back in the streets, theaters, and town hall meetings setting up the Democracy in Europe Movement 2025 (DiEM25). I saw activism as the best way to confront the political and banking establishment. Four years later, in July 2019, our Greek branch, entitled MeRA25, entered Parliament with nine MPs. The fight continues.

You are one of the sharpest critics of neoliberalism today. How would you define neoliberalism?

To begin, let me challenge the term neoliberal. The use of the term in relation to West-Soviet relations was just a cloak under which to hide libertarian industrial feudalism, but neoliberalism has as much to do with financialized capital post-1970s as it does with Cold War geopolitical relations. Similarlyand I know this is a controversial statementtheres nothing neoliberal about the world we live in today. It is neither new in the sense of neo nor liberal in the sense of fostering democratic values. Look at what has been happening in Europe over the last decade. Gigantic bank bailouts are funded through taxation. There is nothing really neoliberal about the use of such vast subsidies from the public to finance capitalists.

Even under the government of Margaret Thatcher in the UK from 1979 to 1990, the height of so-called neoliberalism in the UK, the British state grew rapidly, becoming bigger, more powerful, and more authoritarian than ever. We witnessed a state that was weaponized on behalf of the City of London to the benefit of a very small segment of the population. I dont think we should concede the term neoliberalism to the brutish establishment using state power to redistribute wealth from the haves to the have-nots.

How has this brutish establishment become so dominant in shaping the global order?

The first two decades after World War II were the Golden Era of capitalism for a very simple reason: Franklin Roosevelts New Deal was projected onto the rest of the West under the Bretton Woods system. It was a remarkable, though imperfect, system, a kind of enlightenment without socialism. Structures to restrain financial capital were put into place. Banks could not do as they pleased; thats why bankers hated the Bretton Woods system. Recall that Roosevelt banned bankers from attending the Bretton Woods conference and subjected them to reserve controls and rules against shifting money across international borders.

The result of the Bretton Woods system was a remarkable reduction in inequality concurrent with steady growth, low unemployment, and next to zero inflation. The system was predicated upon the USs status as a surplus country, recycling wealth through Europe and Japan in a variety of ways. By the end of the 1960s, however, the Bretton Woods system proved unsustainable. The US began to incur trade deficits with Europe, Japan, and later China at the same time Wall Street, unrestrained by regulatory boundaries, attracted most of the profits from the rest of the world.

Unshackled financial institutions began creating what amounted to private money. Holding an inflow of $5 billion daily for a mere five minutes was enough to divvy it up into derivatives, opaque investment instruments that contributed to the 2008 financial crisis. This and other forms of financial engineering produced huge volumes of private money, the value of which, as in the 1929 crash, eventually collapsed in domino-like fashion. Authorities in Washington, Brussels, Paris, and Athens immediately transferred the resulting losses onto the shoulders of taxpayers, a form of socialism for bankers. I described this colossal mishandling of our financial system in my 2009 bookThe Global Minotaur, six years before I became the Greek Minister of Finance.

When I became Minister, I believed that a global crisis of capitalism was underway. Imagine, then, my walking into a meeting of the Eurogroup with all the European finance ministers in the room who knew I held this view. I was the red flag in the eyes of the establishment. In the same vein, the German ambassador to Greece and one of the most powerful (and most corrupt) Greek bankers had warned the future, democratically elected Prime Minster that my appointment as Finance Minister would cause them to close ATMs across the country and lead to collapse of the Greek banking system.

Given your experience inside and outside government, do you believe that there is a fundamental tension between capitalism and democracy?

Yes. Compare the character of a democratic election with a general meeting of shareholders of a private corporation. Both are elections, but in the democratic process, the one person-one vote rule applies, whereas in the corporate process, you have one share-one vote, essentially a wealth-based voting structure. My fellow economists, especially the true believers in free markets, love to portray the market as a voting mechanism. It is true that every time you buy a tub of yogurt, you are voting in favor of that brand. The same applies when you buy a Ford as opposed to a Volkswagen. The more money one has, the more votes one casts.

So, if you think of capitalism as a voting mechanism, it is anti-democratic in the sense that money determines power. The evolution of capitalism over the last few centuries is a history of the constant transfer of power to the wealthy, including the power to make decisions that affect the distribution of income.

Over time, power has been redistributed from the political sphere to the economic sphere. Until the early eighteenth century, there was no difference between these spheres. If you were the king or the baron, you also were rich. And if you were rich, you belonged to the nobility. With the rise of capitalism, a lowly merchant could become economically powerful. As the separation of the political and the economic evolved, power gradually transferred to the latter. What we now call democracy is not real democracy given the growing influence of economic power. To be sure, the voting franchise has been extended to all males (from only landowners), to women, and to blacks. A parallel democratization process has not occurred in the economic sphere, where power has become less inclusive and increasingly concentrated.

From the 1870s to the 1920s, democracy gradually became disempowered as the corporate worlda democracy-free zoneemerged. Since the end of the Bretton Woods system in the 1970s, power has migrated to finance. Goldman Sachs suddenly became more important than Ford, General Motors, or General Electric. Even corporations like Apple and Google are increasingly becoming financialized. Apple, for example, is sitting on hundreds of billions of dollars, and it is operating more like a financier than an iPhone producer.

This dynamic guarantees that when we vote, an act of celebrating democracy, we increasingly are participating in a sphere that has become totally disempowered. Capitalism is predicated on defeating democracy, even as the democratic cloak continues to legitimize the prevailing system.

Given this fundamental tension between capitalism and democracy, do you believe the European Union can be reformed? And if so, how?

We must aim for something much closer to a democratic federated Europe than what we have now. The tragedy is that the moment you start making such a case as the only antidote to disintegration, you serve the cause of nationalists, xenophobes, racists, and fascists. In ten years, either were going to have a democratic federated European Union, or the political monsters will be victorious.

How do we achieve a future democratic federation? The most urgent and difficult task is to go out into the streets of Athens, Rome, Berlin, Paris, and Lisbon and have a discussion with people about the crisis the EU faces. Many dont want to hear about Europes future anymore. What used to be a very attractive vision of a unified Europe as a larger homeland for all its citizens has become toxic in the minds and the hearts of many Europeans. For them, the democratic European Union has become synonymous with an anti-humanist, even totalitarian, vision. We need to construct a new vision to counteract this kind of thinking.

You have been at the forefront of the recently formed Democracy in Europe Movement 2025 (DiEM25). Tell us about DiEM25s pan-European mission and strategy.

DiEM25 seeks to put forward proposals that stimulate cooperation that is truly democratic. This will take time and will require recreating European institutions and a political economy that includes a massive Green New Deal or similar strategy. We must spend immediately at least 500 billion Euros annually on green energy, green transport, and a green transition in industry and agriculture. We can do this by creatively harnessing the power of existing institutions. The European Investment Bank, for example, could issue bonds worth half a trillion Euros every year, with that money going toward good-quality green jobs and technologies. The European Central Bank, sitting on the sidelines, could be ready to buy these bonds if needed to keep inflation in check. At the same time, we must engage with a broad spectrum of groups to stabilize Europe and so to bring back hope. With that movement underway, we can then have a discussion about democratic governance of the EU.

Im an old-fashioned lefty. I dont believe in destroying institutions. I believe in taking them over and transforming them into true public servants.

What does DiEM25 offer beyond the proposals of parties like Die Linke in Germany, Podemos in Spain, or other Green or Left parties throughout Europe?

Most members of these groups are our friends and comrades. We share a humanist attitude towards life and capitalism. The reason we created DiEM25 is that the major crises in Europe require local and national action as well as pan-European, if not global, action. It makes no sense to prioritize the local and national over the transnational, or vice versa. We must operate simultaneously at all levels.

For example, the design of urban transportation systems must consider the planetary, or systemic, impacts of alternative choices. The problem with national political parties is that they are not very good at such systemic thinking. What we need in Europe is a pan-European movement, which is more than a confederacy of autonomously operating states that make promises to local and national electorates independently of one another and then get together in Brussels to discuss the promises that each has committed to. This model is doomed to fail.

When DiEM25 was inaugurated in February of 2016, we sought to bring together Podemos, Die Linke, and allies from the UK to develop a Green New Deal for Europe. We hoped to unify such movements around a common pan-European program. It didnt work out that way. Why? Die Linke comprises two distinct groups: one faction believes that the European Union is beyond redemption and should be dismantled; the other believes that the EU is salvageable through democratic activism and social transformation, a view shared by DiEM. This division between supporters of exit and remain stood in the way of an alliance.

Another impediment to unity was that Podemos and others opposed a European voice in national and local policies and decision-making. What is Podemos going to say, for example, about the level and allocation of investment funds among member states? If a Podemos candidate is elected to the European Parliament, what financial policies will she support? We need clarity and unity on such issuesto have a voice not of a Greek, a German, or a Spaniard, but of a European internationalist. We will continue to struggle to create a unified, coherent agenda for all of Europe. Unity without cohesion is the curse of the left.

Lets not forget that the historical call was not for workers of each nation to organize within their borders. It was for workers of the world to unite.

Are there lessons to be learned from previous episodes of leftist internationalism, such as the Internationals, for our current time of global mobilization?

There are many lessons. Anybody who doesnt learn from history is a dangerous fanatic. Lesson number one is that socialist nationalism is the worst antidote to national socialism. Remember what happened in World War I when the German Social Democrats were co-opted into a nationalist agenda and supported the war effort of Germany against the much of Europe. That kind of socialist nationalism will always be gobbled up by Nazism. Anyone who supports a left-wing agenda and at the same time supports a nationalist, populist workers agenda is going to be devoured by fascists. They will end up effectively blowing wind into the fascists sails, intentionally or not.

Lesson number two is that Internationals fail if they are just a confederacy of national parties. The moment agendas and organizations are nationally based, as was the case in postwar Communist parties, the international movement will inevitably fragment and collapse. This is why DiEM25 places all its energies into not becoming a confederacy of a Greek DiEM25, a German DiEM25, and an Italian DiEM25. This is not a theoretical matter, but a practical one: transnationality as opposed to confederacy is critical to building a new, progressive political enterprise. Studying the failures of earlier Internationals is fundamental in shaping this strategy.

To be clear, when we created DiEM25, we envisioned a movement, not a party. And it remains a movement, but we decided about a year ago to create our own electoral wings in each country. In Germany, DiEM25 created Democratie Europa (Democracy in Europe); in Denmark, Alternativet (The Alternative). In short, if you are a member of a DiEM25created party, you also are a member of the larger movement. But you also can be a member of the larger movement without membership in a DiEM25-created party.

In a forthcoming book, you imagine another world in 2035 in which global financial capital is essentially demolished. What would this world look like? What would it take to get there?

I begin with the view that the present system is, simply stated, both awful and unsustainable. My story is told from the perspective of 2035, when my characters discover that, back in 2008, at the height of our crisis, the timeline split into two: one that you and I inhabit and another one that yielded a post-capitalist society. It is my narrative strategy for sketching out how post-capitalism could work and feel today had our response to the 2008 been different.

My forthcoming book, entitledAnother Now: Dispatches from an AlternativePresent, asks the following questions: Could the world be non-capitalist or post-capitalist? Could we see humanism in action? What would it look like? What would socialist corporations look like? How would they function? How would democracy function? What would happen to borders, migration, and defense? I try to create a vision of a liberal, socialist society that is not based on private property but does use money as a vehicle for exchange and markets as coordinating devices. I preserve money and markets because the alternative would be to fall to some fearsome hierarchical control, which, for me, is a nightmare scenario.

A deep transformation of values and institutions is essential to building a world of solidarity, well-being, and ecological resiliencewhat we call a Great Transitionis more urgent than ever. In a dark time, what basis for hope and advice can you offer fellow internationalists at this critical, historic moment?

We have the tools necessary in order to spend at least five percent of the global GDP on a Great Transition that saves the planet. Technically, we know how to create a new Bretton Woods, a progressive Green New Deal that diverts resources to saving the planet and creating quality green jobs across the globe.

To achieve such a future, we must offer a cautionary note regarding the role of borders. Some on the left are unfortunately moving toward the belief that migrants are a threat to domestic workers. That is a right-wing narrative that is factually untrue. We need to emancipate progressives from the notion that strong borders protect the working class. They do not. They are a scar on the face of the Earth, and they harm labor across the world.

Teaser photo credit: By Robert Crc Subversive festival media, FAL

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Another Europe is Possible - Resilience

This retired professor from IIT-Delhi is on a mission to unite the youth against the rising hatred and intolerance in the country – EdexLive

At a time when there is so much unrest, violence and hatred among the people in this country, Vipin Tripathi, a retired professor from Indian Institute of Technology Delhi, is trying to spread the message of peace and love among people across all the age groups - by distributing flyers, organising workshops on humanism, interacting with them on the serious issues in the country. He started this mission of spreading peace in 1989 and has been practising it till date. He says, "I am doing this because there is so much hatred and violence spewing in the world today. And it has increased in the past few years. Let's take the Kashmir situation post the Article 370 debacle, for example. It has been more than three months since the government has restricted people's movement, they are surrounded by the Indian army and phone calls have also been barred. The present Indian government thinks that they have done something daring, but their approach was completely wrong. They should have taken the Kashmiris into confidence before they could revoke section 370. They are as much Indians as we are. This has led to further polarisation in our country."

When it comes to the issue of Kashmir, Tripathi wants youngsters to raise their voices and tell the government what is right and wrong. He adds, "I want them to understand the agony of Kashmiris so that they can unite and fight on their behalf. I just want to tell them that we are not in war with Kashmir."

Tripathi also works as a convener for a non-governmental, not-for-profit organisation called Sadhbav thataims at developing grassroots resistance against communalism and mobilising people on basic issues like education. He explains, "This organisation was started in 1990 after the Bhagalpur riots and Ramshila Poojan movement which shook our country. We stood for clarity of perception in the midst of communal frenzy and organised marches, fasts, corner meetings and poster and flyer campaigns."

Apart from all this, Tripathi has been distributing flyers among people to educate them about different national and regional issues, all by himself. He also organises workshops for school and college students. While the Science students attend his physics workshop, the Arts students attend history workshops. "Even if you are not a student, you can attend one of these workshops to gain knowledge and interact with people. The speciality of my workshops is that the first half is related to the subject and the second half is all about humanism. I feel that opening up with students and youngsters for dialogue is the only way to curb hatred and violence. The prejudices are so strong that they are rooted in the psyche of young minds. Dialogue will help them to fight their own prejudices. Though it is a slow process, I feel that it will be successful one day," says Tripathi who is trying to reach every corner of North India.

Media plays a negative roleApart from people and the government, the retired Physics professor believes that media including newspaper, television and social media have a greater role to play in conditioning the minds of young citizens. "These days, media hardly talks about the real issues that are of concern to society. By promoting selective news, they are directing people to form wrong opinions about fellow citizens."

NRC to roast the countryAnother issue that Tripathi is worried about is the imposition ofNational Register of Citizens (NRC) policy in Assam that now threatens to be in force in the rest of the country. "When India gained independence in 1947, Gandhi said that people living in this country are the citizens of India. Then why this policy now? A few weeks ago, I travelled to Assam to do some groundwork. Most of these people who are out of the NRC list are not just non-Hindus. It includes poor and hard-working farmers who belong to different castes. Just because they did not have sufficient proof to prove their nationality does not mean they should be thrown out of the country. Hence I am going to pick this issue and talk to the people as well as parliament members."

During the last parliament elections, Tripathi started working on a project that aims to inculcate 'inclusive growth'. This includes the political, cultural, economic and educational inclusivity to bring the marginal section of the society to the mainstream. He says, "I will be conducting workshops on this theme across the country. We have already started writing booklets on this theme."

All 365 days dedicated to social workWhen Tripathi was working at IITD, he would dedicate his summer holidays and evening hours during the college days to reach out to people. Now that he is retired, he dedicates all 365 days to his mission of peace. He says, "My father Hardas Sharma was a freedom fighter and I have always followed the Gandhian principles."

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This retired professor from IIT-Delhi is on a mission to unite the youth against the rising hatred and intolerance in the country - EdexLive

Opinion | Angela Merkel’s inclusive and firm leadership shall be missed – Livemint

Mutti, Germans call her, an endearing term for mother", with all the warmth, kindness and inclination to occasionally use the metaphorical stick. When she speaks, the world listens.

Angela Merkel, the first woman to become the chancellor of Germany in 2005, will not seek re-election in 2021. In a week when the world is looking at history to commemorate the fall of the Berlin Wall, her name figures right up there along with the worlds greats. Without pomp, and even less pageantry, whether at glitzy events like the annual World Economic Forum at Davos or the closed conclaves of the Group of Seven, and even in smaller settings like bilateral meetings with some of the worlds most powerful leadersshe was recently in IndiaMerkel has never let herself become the story.

Her priority has been Germany and Europe, and building a strong European foreign policy. In a world that is badly in need of healing and mending, even her worst critics cannot find any fault with her, other than to say that shes too inclusive.

Born in Hamburg, West Germany, Merkel moved to East Germany as a child with her family. She has a doctorate in quantum chemistry and worked as a research scientist, entering politics only after the fall of the Berlin Wall in 1989. She was elected to the German Bundestag and rose in politics as the protg of chancellor Helmut Kohl. Merkel held several political positions till she was elected secretary general of her party, the Christian Democratic Union (CDU), before becoming its first female leader. In October 2018, Merkel said she would not seek re-election as the CDUs, nor as Germanys chancellor the year after next.

One area where Merkels voice is already being missed is the current tensions in the North Atlantic Treaty Organization (Nato), the post-war grouping of the Allies. French President Emmanuel Macron recently said theres a brain drain within, and that Natos headNorways Jens Stoltenbergis a lightweight. Relations between Europe and the US have never been as acrimonious as they are now, and US President Donald Trump appears to be fishing in troubled waters from across the pond.

Merkel exemplifies a range of leadership qualities, from rigorous resilience and fair-play to humanity and hard work, all rolled in one. These are qualities that European Union (EU) leaders can take lessons fromespecially at a time when Europe is in search of an identity that would enable it to preserve its differences and diversity without having to sacrifice much-needed economic growth.

Germans are Europes most productive people (they work the least number of hours, much to the envy of the French), and, at a little over 80 million, they carry the industrial gravitas of China, which is over a billion strong. Merkel was the first to lead a trade delegation to China, followed by France.

The German work ethic, of which Merkel is a complete reflection, is not a fairy tale. It is a reality that comes from self respect and respect for ones country. Its a sentiment that is nurtured by the countrys education system and instilled in its workforce, be it in dealing with its current economic issuesinfrastructure, for exampleor pulling back from a heavy dependence on coal.

Merkel has just announced an ambitious environmental programme. A Lutheran who has studied Marxism and Leninism, she is no evangelist of any ism" other than pragmatism and humanism. Her kind of rigorous compassion is a combination of skill and experience that few leaders have. Among the Europeans who have displayed such capacity was probably the French visionary Jacques Delors, who knit socialist policies with market forces to draw the grand lines of the European common market as it began to take shape.

Two recent instances where Merkel bit the bullet show her vision and quest for a democratic middle ground. One was when she hit the ground running and saved the EU from doddering after the Greek financial crisis a decade ago. The other was her decision to take over a million Syrians fleeing war and poverty some years ago. We can do this," she told her nation. The salient message to the world, especially to those across the pond, was this: You cannot ceaselessly bomb a people and expect them not to run to safety. Dislocation has never been a natural choice for human beings, and it has not got any better in a world where people want more and more, and where theres less and less of everything, except instruments of war and nervous leaders.

History will prove her right," the European Commissions president Jean-Claude Junker had told Germanys mass circulation daily, Bild, and that if she had closed the German borders, Austria and Hungary would have collapsed due to the high number of refugees."

When Merkel said, we can do this", apropos Syrian refugees, she wasnt looking for applause. European prosperity is the direct result of the absence of war and a difficult relationship with Russia (with which west European countries share borders) that few non-Europeans comprehend.

Perhaps the one time she gave any emotion away without words was during a photo-op, when Trump invited her to stand next to him in the first row while she preferred to stay in the second rung. Cameras caught her gently rolling her eyes after the US president had turned his back. Non-committal, yet determined in her own waythats Angela Merkel.

Chitra Subramaniam is an award-winning journalist and author.

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Opinion | Angela Merkel's inclusive and firm leadership shall be missed - Livemint

Three Reasons I’m Neither Spiritual Nor Religious – Patheos

This week I sat on a panel on LGBTQ+ spirituality organized by the multicultural office and the social work department at the University of Arkansas.

First question out of the gate: Do you consider yourself more spiritual or religious?

As I sat and listened to responses, I realized this discussion, about spiritual vs. religious, is really part of the popular conversation. Panelists had very thoughtful things to say.

Meanwhile, I kept thinking to myself: I dont consider myself spiritualor religious. I dont really use those categories when I speak or write.

So then what am I if Im neither spiritual nor religious? Clearly Im not one of the nones or dones. Im a Lutheran pastor who blogs at the Progressive Christian channel on Patheos, after all. How can I be neither spiritual nor religious?

By the time it was my turn to speak, I decided to answer simply: I dont think of myself as spiritual or religious. I think of myself as someone trying to practice Christianity in the social gospel tradition.

Let me try to unpack that. So first, I do believe that faith is centered in life lived together. This is perhaps my one struggle with those who say they are spiritual but not religious. I totally believe them that they are. But I do think when people say that they are thinking of spirituality as a largely individual activity. Its something you are, not something done together.

So thesocial gospel emphasizes the social implications of the good news of Jesus. In the most religious way of talking about this, people would say we try to live like Jesus, practice social justice in theway of Jesus. This is why frequently social gospel Christianity gets involved in politics, or community organizing, or shareholder meetings. Because it is a faith that has direct social implications. Always.

And it is thegospel because gospel is whatever it was that Jesus (and the movement he started) was teaching and enacting in the coming kin-dom of God. Good news for the poor and oppressed. Liberation for those in bondage.

So you could say social gospel is both religious (in that it applies to institutions and structures) and spiritual (maintaining a spirited connection to the teachings of Jesus). But I wonder if perhaps it can be clarifying and freeing to consider dropping the terms religious and spiritual altogether in order to get beyond a false dichotomy between individualized spirituality and institutionalized religion.

Another way to talk about this kind of Christianity may be to call it Christian humanism. One of my favorite Lutheran theologians, N.F.S. Grundtvig, frequently emphasized in his writings that we are human first, then Christian.

Human first, then Christian.

I think this is perhaps one of the reasons many who are finding a more mature form of faith in their own lives feel a need to reject religion. Its because the religious community they experienced turned on them, betrayed them, lost its way somehow, and did so in the name of faith.

And typically that harm came because the community allowed its religious commitments, its doctrine or norms, to take precedence over the shared humanity of those in the community.

Once you harm or alienate someone in the name of faith, you are putting Christianity ahead of humanity.

And then Grundtvig will remind you, Human first, then Christian.

A commitment to Christian humanism is also a much more open faith than the closed faith of more doctrinally pure communities. If the human comes first, then there is space for the Christian to engage the Muslim, the Buddhist, the agnostic, in ways that celebrate the shared humanity between them, and then discover how their faith tradition enhances and strengthens their shared humanity.

Recently my own seminary alma mater published a study indicating that based on current projections, average weekly attendance in our denomination will drop from 899,000 in 2017 to just 15,811 in 2041.

No, there arent typos in those two numbers.

People have all kinds of theories on why faith in the United States is in decline, and how to reverse it. Large conservative groups typically say its because the liberal churches are becoming too much like the culture. Liberal churches say it is because the conservatives are harming people and then alienating them.

In a bigger view, a lot of people are coming to the conclusion that we simply live in a society where it is increasingly difficult to believe in God, and instead people are shifting their faith commitments to other things.

Were enchanted by capitalism, for example. Its the new religion AND the new spirituality all woven together.

I do not have a clear-eyed simple explanation for why the decline is happening. The decline probably has multiple causes, not the least of which are decreasing birth rates, a move towards individualism, and more.

But I do know that for my money, getting beyond the hand-wringing over decline and simply living the social gospel is my way forward.

Dont get me wrong. I very much love many of the ways religious community has functioned as a voluntary society in my life. I love corporate worship and potlucks and all of that.

But because the gospel has social implications, I tend to think discipleship is much less about getting everyone to sign back up for all the measures by which we measured religiosity in the 20th century, and instead start wondering, Who is going to city council meeting Tuesday night to advocate for better bussing? Where are all the voices of people of faith in the public square?

Even if Christianity becomes a small voice in United States culture, if that voice both speaks and enacts the kin-dom of God in tangible ways in the world, then there would not have actually been a decline at all, just a shift.

Maybe the best thing for Christianity in this moment is for it to become neither religious nor spiritual.

Then the community that does exist will have learned to do the hard work of the gospel in the world rather than asking everybody outside the church to do the hard work of coming back into it.

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Three Reasons I'm Neither Spiritual Nor Religious - Patheos