Women more likely to be warned away from surgery careers due to gender – Physician’s Weekly

By Vishwadha Chander

(Reuters Health) Punishing hours and concerns about having little time to marry and have children deter both male and female medical students from choosing careers in surgery, but more women say theyve been warned away from the field because of their gender, a survey found.

Researchers sent surveys to roughly 720 students at Harvard Medical School. Among the 261 who responded, similar proportions of both genders intended to become surgeons- roughly one in four men and one in five women.

Roughly similar proportions of men and women about 61% and 65%, respectively said someone had spoken to them to try to dissuade them from a career in surgery, especially if they planned to raise a family.

But 72.7% of women believed the verbal discouragement was related to their gender and their desire for a family, compared to 1.5% of the men, researchers report in Annals of Surgery. And 29% of women reported age-based discouragement, compared to 1.5% of the men.

Despite an equal number of men and women in medical school, fewer than 25% of surgeons are women, study coauthor Dr. Faith Robertson, a neurosurgery resident at Massachusetts General Hospital, told Reuters Health by email. Our study was important to understand why gender ratios change between medical school and practice.

Students generally decide which field to enter during the latter half of medical school, as they complete medical and surgical rotations and speak to peers, mentors and family members, the study authors note.

Discouragement from faculty at the pre-med and student-level definitely has an impact, study coauthor Dr. Susan Pories of Harvard Medical School in Boston told Reuters Health by email. Pories chairs the American College of Surgeons Women in Surgery Committee and is past president of the Association of Women Surgeons.

Dr. Carmen Fong, a colorectal surgeon at the Mount Sinai Health System in New York City, told Reuters Health that during her surgery rotation in medical school, we had zero female surgeons, and this was at a relatively large hospital in a state capital. There were plenty of women in primary care, but I wanted a female surgeon who had made it, who could tell me that I could balance a life and an academic surgical career.

Dr. Rachel Levine, Associate Vice Chair for Womens Academic Careers in the Department of Medicine at Johns Hopkins University School of Medicine, points out that stereotypes also contribute to gender-based discouragement directed at women.

We think of men as strong, decisive, risk-taking traits more often associated with surgeons. We often think of women as nurturing and helpful, Levine, who was not a part of the study, told Reuters Health. Its sometimes challenging to see a woman as a surgeon because she doesnt fit these typical traits.

The authors say their study at a private, urban institution may not reflect the situation at other universities, but they believe it calls for systemic change, including policies about maternity and paternity leave.

We have to work towards equal pay, leadership roles for women and parental leave policies for men and women, said Pories.

Robertson said the field of surgery has unique demands but also an abundance of unique rewards.

We owe it to medical students to empower them to pursue fields based on their passions, and to patients to have a body of surgeons that reflects population diversity, she said. By discouraging individuals, particularly minorities, from entering the field, we do both a disservice.

The reality is women are successful in all surgical specialties (while still) achieving work-life balance, Pories said.

SOURCE: http://bit.ly/2QBgBMn Annals of Surgery, online October 9, 2019.

(Reporting by Vishwadha Chander)

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First times in the emergency department – Scope

First times are hard to forget.

They make for great stories -- nostalgicand self-deprecating reminders of who we were before we became who we are now.Medical school is the setting for many first times; stories of jittery firstblood draws, or students nodding along to heart sounds that they didn'tactually hear, are ubiquitous. However, I wish we would more directly address themistakes that can happen in these first times.

I have just stepped out of my second procedures shift in the emergency department, where I have the opportunity to practice skills like placing IVs, doing electrocardiograms and placing sutures on patients with real medical issues ranging from shortness of breath to hemorrhage. I've attended a formal training session and then conducted these procedures on several patients, but every new patient still feels like the first time for me.

I wear a false cloak of confidence each time I introduce myself as a medical student, and politely ask if a patient is willing to let me perform the procedure on them -- earlier today, it was an IV. I used small talk as a distraction from the sharp needle I was about to puncture into the patient's arm -- a distraction that worked well for both of us and further masked my inexperience.

As I drove the needle forward, I was well aware of the gamble I took -- I had no clue if there would be a flash of blood to indicate I was where I needed to be. While the anxiety burned my fingertips, I continued to coax the patient through this procedure, managing to compose a steadiness in my voice that I wished would exist everywhere else.

I found a vein --but sometimesI don't. I always make eye contact with a nearby nurse, letting the panic settlein my eyes. They confirm my successes with a slight nod or my failures with aswift take-over. I avoid eye contact with the patients, hoping they'll continueto be blind to my unease.

Perhaps that is the true skill I am learning to hone during these shifts -- "fake it 'til you make it," as they say. This makes me uncomfortable. I want the patient to trust me and believe that I know what I am doing, but do they deserve to know that I don't actually feel this way?

I am lucky that the patients I have worked with have been so encouraging of my learning process and understanding of my imperfections. I remember one patient waving off his concerned son after I could not get my IV in on the first try: "Let her learn. I feel fine!" he said, before giving me the thumbs up to try again. But I know that not every patient will be so forgiving.

The idea of "practicing" on realpatients is discomforting. When I make mistakes, the patients will have to dealwith the repercussions -- a bruise from a failed blood draw or an uneven scarfrom an imperfect suture. This lingering guilt makes the failure that much moreformidable for me. It is difficult to place my learning above a patient's needfor the best care possible; and when I ask nurses if I can perform a procedurerather than them, I feel as if I am robbing a patient of that care.

I realize that as a medical studentI will one day be responsible for patients as a full-fledged doctor, with few peopleabove me on the ladder of support to call for help. These moments of uncertaintythat I traverse through now are my investment into my ability to care forpatients in the future; I am asking the patients I see today to make thatinvestment in me as well.

Their investment is an act ofaltruism that they may not even be aware of. I wish I could repay their faithin my future self, but I can't. With each of these acts of altruism, though, Ifind the vein a little quicker, and hold the needle a little more steadily.

One day, it will stop feeling like the first time.

Stanford MedicineUnplugged is a forum for students to chronicle their experiences in medical school. The student-penned entries appear on Scope once a week during the academic year; the entire blog series can be found in the Stanford Medicine Unpluggedcategory.

Tasnim Ahmed is a second-year medical student from Bangladesh and Queens, New York. She has a background in cognitive neuroscience and education. Her interests include global health, women's health, and embroidery (for her own health).

Photo by josh

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First times in the emergency department - Scope

Huge variation in time and money for GP-based teaching in medical schools – GP online

Analysis of 36 UK medical schools by the Society for Academic Primary Care (SAPC) found significant gaps between institutions in the overall amount of GP teaching in their curricula.

In the medical school with the greatest focus on GP teaching, 19% of teaching overall was within general practice or by GPs, compared with just 3.9% in the medical school with the lowest proportion of GP teaching. On average,9.2% of medical schools' teaching was GP-based.

A near five-fold variation was seen in the average number of sessions assigned to GP teaching per student in curricula at different medical schools. GP-based sessions per student ranged from 65.3 to 313 - equivalent to 6.5 weeks to 31.3 weeks.

Meanwhile, the average payment per session for clinical GP teaching was 58.74 per student per session, but payment varied from 32.21 to 120.00 across the UK.

Three quarters of medical schools experienced difficulty in recruiting GP teaching practices, citing poor pay for clinicians, difficulty where placements were not in blocks, or where students had excessive travel.

Two medical schools' curricula were found to include none of a list of key topics recommended by Health Education England (HEE) to encourage doctors into general practice. Just 14% said they delivered sessions on all recommended topics from the HEE list.

The findings follow a BJGP study last month, which revealed that the actual cost of teaching undergraduate medical students in general practice was almost double what practices receive for placements.

The SAPC report, which examined the exposure of undergraduate medical students in the UK to general practice, found that the number of GP teaching sessions in undergraduate schools has plateaued since 2002. This was despite perceptions among educators that GP sessions had increased over the past five years.

Medical schools established before the start of the 21st century had a significantly lower percentage of GP teaching than the percentage in newer medical schools: 8.3% vs 12.9%, the report found. While, the number of compulsory sessions of practice-based GP teaching varied between schools, varied between 248 and 27.

Dr Hugh Alberti, who is sub dean for primary and community care at the University of Newcastle, said variation in the amount of time given to GP teaching was down to both cultural and historical reasons, with hospitals traditionally seen as the natural learning arena for medical graduates.

But he said it was important that attitudes changed if more students were to be attracted into working in general practice.

The arguments for having more students in general practice are very simple; its good for the students because they get high quality teaching and its good for general practice because more students are likely to become GPs because theyve had more time in that area.

If we dont get more students into practices, were not going to get more students becoming GPs and were just going to continue the recruitment problem.'

He added that practices were currently 'making a loss on average' from training students. 'If it costs them 110 [to train a student] and were paying them on average 55, then practices are potentially making a loss,' he said.Until we make it cost neutral for them, then its always going to be a challenge.'

Health secretary Matt Hancock announced last month that more than 3,500 doctors had been recruited to GP specialty training this year. But the RCGP has warned thatthe NHS needs to train 5,000 GPs a year to keep patients safe.

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LW West Student Nominated For Congress Of Future Medical Leaders – New Lenox, IL Patch

NEW LENOX, IL Margaret Randle, a sophomore at Lincoln-Way West will be a delegate to the Congress of Future Medical Leaders in Lowell, Massachusetts June 24-26, 2020. According to the district, Randle's nomination was signed by Dr. Mario Capecchi, winner of the Nobel Prize in Medicine and the Science Director of the National Academy of Future Physicians and Medical Scientists to represent Illinois based on her academic achievement, leadership potential and determination to serve humanity in the field of medicine.

The Congress is an honors-only program for high school students who want to become physicians or go into medical research fields.

During the three-day Congress, the district said Randle will join students from across the country and hear Nobel Laureates and National Medal of Science Winners talk about leading medical research; be given advice from Ivy League and top medical school deans on what to expect in medical school; witness stories told by patients who are living medical miracles; be inspired by fellow teen medical science prodigies; and learn about cutting edge advances and the future in medicine and medical technology.

Randle's acceptance letter states: "This is a crucial time in America when we need more doctors and medical scientists who are even better prepared for a future that is changing exponentially. Focused, bright and determined students like Margaret Randle are our future and she deserves all the mentoring and guidance we can give her."

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LW West Student Nominated For Congress Of Future Medical Leaders - New Lenox, IL Patch

Aging as a preventable disease and why living to 100 should be easy – Genetic Literacy Project

Science is investigating some intriguing clues suggesting that aging and death may not be as inevitable as we thought.

David Sinclair believes aging is a disease, the most common disease, and he believes it should be aggressively treated. His bookLifespan: Why We Age and Why We Dont Have Towas published in September 2019.

He believes a loss of information is the singular reason why we age. Not just digital information, but epigenetic information that is analog rather than digital. He characterizes the genome as a computer and the epigenome as software. The genetic information is the same in every cell; the epigenome is what instructs a cell to develop into a kidney cell rather than a heart cell.

Experiments with stem cells and cloning are intriguing. Gene therapy shows great promise but there are ethical concerns. Genetic analysis and new technologies are making great strides.

If even a few of the therapies and treatments that are most promising come to fruition, it is not an unreasonable expectation for anyone who is alive and healthy today to reach 100 in good health. [Sinclair said].

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Aging as a preventable disease and why living to 100 should be easy - Genetic Literacy Project

This Week in Running: November 18, 2019 – iRunFar

After two weeks of light racing, trail running and ultrarunning came back with some figurative thunder and lightning. There were two World Mountain Running Association championships in Argentina, and the U.S. won three individual gold medals there, and then there was the prize-money-rich The North Face Endurance Challenge 50 Mile Championships in California too. Weve got all that as well as a quick look at next weekends JFK 50 Mile. Its just another manic Monday, friends.

Thanks to Boa for sponsoring this edition of TWIR!

Fridays up-and-downWorld Mountain Running Championships were marked by heavy rain. The men and women raced on a 14-kilometer course with a river crossing that swelled to waist deep, and the junior boys and girls competed on a weather-altered, two-loop 8k route. It was the first time since 2006 that the championships had been held outside of Europe, and the first time ever that it was held in South America. That perhaps made for a cool race location, but it mightve also thinned the field. 106 men finished last years race, and just 77 this year. 61 women finished this year, against 77 in 2018. Lets not let that overshadow a great day for many though.

Women

Grayson Murphy (USA) is pretty much a trail running rookie and, get this, now a mountain running world champion. It sounds contradictory, but Murphy, 24 years old and a five-time All-American while at the University of Utah, went to the front right away and finished in 1:15:20.

Murphys quick entry into the discipline also includes a first- and second-place finish at two Cirque Seriesraces, a second at this yearsBridger Ridge Runrace in Montana, and of course a win at theU.S. Mountain Running Championshipsin New Hampshire earlier too.

Elise Poncet(France) chased to a second-place 1:15:41, and Phillipa Williams(U.K.) was third in 1:16:45.

The 2019 World Mountain Running Championships womens podium (l-to-r): 3. Phillipa Williams, 1. Grayson Murphy, and 2. Elise Poncet. Photo: World Mountain Running Association

The rest of the top 10 ran as:

4 Adela Stranska(Czech Republic) 1:17:535 Lizaida Thalia Valdivia Margarino(Peru) 1:18:106 Christel Dewalle(France) 1:18:167 Anais Sabrie(France) 1:18:308 Elisa Sortini(Italy) 1:18:579 Amily Colling(U.K.) 1:19:0310 Tereza Hrochova(Czech Republic) 1:19:39

Dewalle previously served a four-month doping ban after a positive test for the stimulant Heptaminol at the 2016 Skyrunning World Championships.

Other U.S. runners were:

Kenyan and Ugandan runners took three of the top-four finish positions a year ago, but logistical issues prevented them from attending this years race.

France won the team gold, the Czech Republic team silver, and the U.K. bronze.

Men

Joe Gray(USA) won this race back in 2016 in Bulgaria in an all-uphill year, and did it again. A perennial member of the U.S. mountain running team, Gray won his second mountain running world championships in form just like womens winner Murphyby going to the front at the start and leading the entire way. Gray finished in 1:05:13, though second-place Cesare Maestri(Italy) was just eight seconds back. Marek Chrascina (Czech Republic) was a surprise third in 1:05:57.

Joe Gray, 2019 World Mountain Running Champion. Photo: World Mountain Running Association

The rest of the top 10 included:

4 Jan Janu(Czech Republic) 1:06:005 Alexandre Fine(France) 1:06:076 Manuel Innerhofer(Austria) 1:06:157 Andrew Douglas(U.K.) 1:06:228 Jacob Adkin(U.K.) 1:06:339 Xavier Chevrier (Italy) 1:07:2110 Jachym Kovar(Czech Republic) 1:07:27

Other U.S. runners included:

The Czechs scored an upset win in the team competition, besting second-place U.S. and third-place Italy. Uganda had won team gold each of the last two years, but as noted above, did not compete this year.

Full results.

For the first time, the shorter, or classic, World Mountain Running Championships, and the World Mountain Running Long Distance Championshipswere held on back-to-back days at the same locale. That allowed a few ambitious runners to double, but similar to the classic race, race numbers were down. Just 29 women finished versus 52 a year ago, for instance.

Women

Admit it armchair quarterbacks, Cristina Simion(Romania) wasnt on your radar. Four days shy of her 28th birthday, Simion shocked the world and won individual gold in 3:49:57. French teammates Adeline RocheandBlandine LHirondel ran 3:51:56 and 3:52:07 for second and third. LHirondel won the Trail Running World Championshipsearlier this year.

Cristina Simion, 2019 World Mountain Running Long Distance Champion. Photo: World Mountain Running Association

Also in the top 10 were:

4 Silvia Rampazzo(Italy) 3:565 Sheila Avils(Spain) 3:566 Ainhoa Sanz(Spain) 3:577 Charlotte Morgan(U.K.) 3:588 Denisa Dragomir(Romania) 3:599 Eli Gordon(Spain) 4:0110 Emily Schmitz (USA) 4:01

Other U.S. runners were:

Men

Much like in the mens and womens short-course races,Jim Walmsley(USA) bolted from the start line and led the entire way, finishing in 3:12:16. Francesco Puppi(Italy) never gave up the chase and surrendered only a small gap. He was second in 3:13:04. 2019 Skyrunner World Series runner-up Oriol Cardona(Spain) was a distant third in 3:20:24.

Jim Walmsley, 2019 World Mountain Running Long Distance Champion. Photo: World Mountain Running Association

Well go top 10 here too:

4 Jonathan Albon(U.K.) 3:225 Andreu Simon(Spain) 3:256 Hayden Hawks(USA) 3:267 Antonio Martinez(Spain) 3:278 Gabrielle Bacchion(Italy) 3:289 Nicolas Martin (France) 3:2810 David Sinclair(USA) 3:29

The fourth U.S. runner was 31st-placeMario Mendozain 3:42.

Despite putting three runners in the top 10, Spain did better than the U.S. and won team gold. The U.S. was second, and Italy was third.

Full results.

iRunFar was atThe North Face Endurance Challenge 50 Mile Championships race with its full build of pre- and post-race interviews, and in-race coverage. The greater race dynamics have been featured in more detail separately. The races $10,000 first-place prize remained, but for me at home on my couch (or actually at the North Pole amusement park in Colorado Springs, Colorado), it did feel like this years race lost a bit of its starpower relative to prior years. The finish times when measured against the 2017 edition on this same course bear that out too.

Women

Fifty-mile ace YiOu Wangruled her home trails, particularly in the races second half, and won in 7:21. The time was 13 minutes back of whatIda Nilsson(Sweden) ran here in 2017.

Anne-Marie Madden(Canada) edged Addie Bracy for second, 7:38 to 7:39, though there was officially 88 seconds between the two. The separate results post has already gone 10 deep, but 26 women were included in the pre-race preview and well recap how each did.

The 2019 The North Face Endurance Challenge 50 Mile Championships womens podium (l-to-r): 3. Addie Bracy, 1. YiOu Wang, and 2. Anne-Marie Madden. Photo: iRunFar/Bryon Powell

Drops included Elise Delannoy (France), Anna Mae Flynn,Taylor Nowlin,Katelyn Steen, and Lindsey Ulrich.

Were not completely certain, but it appears that Shelley Doucet(Canada),Nicole Freitag,Heather Lieberg,Kim Magnus (Canada),Julia Stamps Mallon, Roxanne Vogel, and Jana Willsey did not start the race.

Men

Second at this yearsLake Sonoma 50 Mile, just like womens winner Wang,Sbastien Spehler(France) returned to the Golden State and came away victorious. Spehler was near the front all day and won in 6:27. Also just like with the womens race, this winning time too didnt threaten that of the 2017 edition when Tim Frerikswon in 6:02.

Darren Thomasmade a late pass to advance into second in 6:32, andThibaut Garrivier(France) held on for third in 6:35.

Sebastien Spehler, 2019 TNF 50 Mile champion. Photo: iRunFar/Meghan Hicks

Excluding known non-starters, 40 men were on the pre-race preview, and heres how they all did:

Drops among those named in the preview article were limited to Matt Daniels.

It appears that none of Mathieu Blanchard, Patrick Caron, Brian Condon,Dustin Franta, Ryan Kaiser,Bryan Kerl, Hal Koerner, Ryan Montgomery,Hans Paul Pizzinini, Adrien Prigent,Carlos Ruibal, andPaul Weeksstarted the race.

Full results.

The North Face Endurance Challenge 50k Championships

The 50-mile race is the marquee event atThe North Face Endurance Challenge Championships, but the 50k had a good field too.Corinne Shalvoywas just on the wrong side of five hours, but won in 5:00. Race local Jenny Comiskey was second in 5:15, and two-time Olympian Kara Goucher was third in 5:30.Nicholas Handel, um, handled the mens group with a convincing 3:58 win.Brian GillisandJustin Grunewaldwere second and third in 4:11 and 4:15, respectively. Deeper results includedAlex Varner, sixth in 4:35. Full results.

Corinne Shalvoy, The North Face Endurance Challenge 50k Champion. Photo: iRunFar/Meghan Hicks

The North Face Endurance Challenge Marathon Championships

Several well-known names dotted the events marathon distance race. Lauren Johnsonwas sixth overall and first woman in 3:27, andLindsay AllenandNina Carsonwere second and third in 3:48 and 4:00.Jared Smithjumped the mens field and won in 3:06.Seth SwansonandChristopher Concannonwere second and third in 3:10 and 3:18.Rob Krarwas fourth in 3:20, andMike Footewas seventh in 3:39. Full results.

Dead Horse Ultra

The Mad Moose EventsDead Horse Ultrain Moab, Utah had 50-mile, 50k, and 30k races.Anne FlowerandJeason Murphyfinished atop the 50-mile race in 7:43 and 6:25.Nora Weatherwon the 50k in 4:05, just 36 seconds in front of second-placeAbigail Moore. The mens race was close too with only three minutes between the front five. Jesse Wesolowskiescaped the group though to lead in 3:41, 19 seconds better thanTyler Hagen. And then in the 30k, Reese RulandandTimmy Parrwon in 2:12 and 1:46, respectively. It was a new course record for Parr, beating a record he set in 2018.Full results.

Wild Hare 50 Mile

Breanna FancherandThomas Orfwon the Tejas Trails Wild Hare 50 Milerace between Austin and Houston, Texas. The two frontrunners prevailed in 9:52 and 7:24.Shandra MooreandWade Barrettwon the accompanying 50k in 4:39 and 4:16. Full results.

NYRR NYC 60k

It doesnt have the same kind of race size as the recentNew York City Marathon, but theNYRR NYC 60k(37.2 miles) still had a Central Park finish. In fact, the race course was entirely in Central Park with nine loops. Tiffany EnglandandJames Gormandid it the fastest with 4:47 and 4:04 finishes. Full results.

Itll be the 57th year for the point-to-pointJFK 50 Milerace. The start list is some 28 pages long, sorted alphabetically, but we spotted a few familiar names.

Women

Men

Full entrant list.

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This Week in Running: November 18, 2019 - iRunFar

World Pancreatic Cancer Day: increasing awareness and inspiring action – UNSW Newsroom

Pancreatic cancer is an insidious disease itis often diagnosedat an advanced stage, with about 90% of patients dying within five years of diagnosis.New projections suggest pancreatic cancer will be the second leading cause of cancer mortality by 2025.

This World Pancreatic Cancer Day, we are celebrating some of the many UNSWresearchers who are dedicated to changing those statistics. Cancers with poor outcomes like pancreatic cancer are a key focus area in UNSW Medicine's cancer theme.

Associate Professor Phillips is the Head of the Pancreatic Cancer Translational Research Group and Deputy Director of the Adult Cancer Program at the Lowy Cancer Research Centre at UNSW Medicine.

This year, A/Prof Phillips was a key driver in establishing the Pancreatic Cancer Research Hub, which aims to double the survival of patients with pancreatic cancer by 2030.

She says World Pancreatic Cancer Day is a powerful advocacy event to increase community and government awareness of pancreatic cancer.

It is also a time to reflect on the progress we have made in understanding this terrible disease and focus on the next steps to overcome current clinical challenges to ensure our research efforts bridge the gap and, as in other cancers, improve the outcomes for our patients with pancreatic cancer.

I know that we are on the brink of overturning the unacceptable statistics. Uniting researchers with the community who, unlike in other cancers, dont often get to be a strong voice advocating for themselves and Government will ensure Australian researchers continue to make positive change for pancreatic cancer patients globally.

A/Prof Phillips group has developed a novel cutting-edge way to keep pieces of human pancreatic tumours alive in the laboratory for two weeks after surgical resection.

Our capacity to grow human tumour tissue in the laboratory provides a valuable new clinical tool to test how a patients tumour responds to different chemotherapies and has the potential to immediately inform patient treatment options. Our unique tumour model is superior to other models because it is human in origin and it contains the complex tumour environment present in patients.

In 2016 A/Prof Phillips had a major breakthrough, successfully developing a novel nanomedicine a tiny drug delivery vehicle consisting of a state-of-the-art nanoparticle that can package gene therapy to inhibit any tumour-promoting gene in pancreatic cancer.

With the generous support from the Brian O'Neill Pancreatic Cancer Fundraising Dinner held last night the team will be able to perform essential preclinical studies to test the therapeutic potential of their nano-gene therapy in combination with a clinically approved drug. They also plan on using their expertise to improve the bioavailability of the clinically approved drugs using a nanomedicine approach.

Professor Minoti Apte was the first in the world to isolate and characterise pancreatic stellate cells, a cell type that is now known to play a major role in the progression of both chronic pancreatitis and pancreatic cancer. Coming up with ways to target these cells to prevent them from doing harm is now a major focus of her teams research.

The group has now shown that interrupting the cross-talk between cancer cells and surrounding cells in the microenvironment by targeting a certain signalling pathway reduces tumour growth and eliminates metastasis in early as well as advanced pre-clinical models of pancreatic cancer.

We have also shown that targeting this pathway reduces the risk of recurrence and progression after surgical resection of pancreatic cancer in a mouse model, and are currently working on possible pathways to take our laboratory findings to the clinic, Professor Apte says.

To me, World Pancreatic Cancer Day is a great opportunity to raise awareness in the community about this deadly cancer, but it is also a day to admire the courage and resilience of patients and their carers. These are the people that spur us researchers on to continue working hard to develop new therapeutic approaches to improve outcomes.

Last year, Professor Apte received the Gastroenterological Society of Australia (GESA) Distinguished Researcher Prize 2018. In 2014 she was awarded the Medal of the Order of Australia (OAM), after being named the NSW Woman of the Year in 2015. She was also the 2016 recipient of the Professor Rob Sutherland AO Make a Difference Award at the NSW Premiers Awards for Outstanding Cancer Research an award that recognises highly successful research that is actively changing cancer treatment and improving patient survival.

Dr Angelica Merlot, who is based at the Childrens Cancer Institute, focuses her research on developing new anti-cancer drugs that target drug resistance and suppress cancer spread.

This year, the cancer researcher has won the 2019 NSW Young Woman of the Year award for her achievements and research into treatments for pancreatic and brain cancer. She also won a 2019 Young Tall Poppy Science Award and the 2019 NSW Early Career Researcher of the Year (Biological Sciences) at the NSW Premiers Prizes for Science & Engineering.

Dr Merlot says today is an important day to raise awareness about one of the world's toughest cancers.

This is crucial as it broadens community knowledge, inspires action and supports further research funding for this cancer. It's also a time to remember those whom we have lost and those currently fighting this disease, she says.

Although we've seen a small improvement in the current survival rate, a lot of progress is still required. Further translational research means that there is a greater likelihood that the survival rates can be increased and the journey and treatment of those affected by the cancer can be improved.

Dr Merlot became focused on cancer research as an undergraduate. Her interest in aggressive cancers, such as pancreatic and brain cancer, was motivated by lack of improvement in survival rates over the past decades, largely due to late diagnosis, a lack of screening programs, low awareness of symptoms and a lack of treatment options.

After moving to UNSW Medicine as a Scientia Fellow in 2018, Dr Merlot focused on understanding the mechanisms by which cancer cells grow and adapt to their environment, why drugs become less effective and the development of nanoparticles to improve drug delivery.

Dr Merlots current projects are investigating part of a human cell called the endoplasmic reticulum (ER). The ER is a type of organelle, or subunit within a cell, that has been shown to help cancers grow, spread and develop drug resistance.

Dr Ying Zhu will lead a team of researchers from UNSW to discover much needed early detection methods for pancreatic cancer patients: the UNSW Medicine researcher today received $100,000 grant from the Avner Pancreatic Cancer Foundation. A/Prof Phillips is a co-investigator on this grant.

As current approaches to this research are time and labour intensive, the team will develop an integrated and small device based on nanotechnology for rapid and sensitive exosome analysis. The team will define a set of biomarkers that can differentiate between cancer and non-cancer subjects from cells and plasma carrying early signs of human pancreatic cancer. This novel technology will also be applicable for doctors monitoring the development and customising the treatment of a patients tumour.

Pancreatic cancer is difficult to diagnose in the early stages. Early tumour cant be observed during routine physical exams as the pancreas is deep inside the body. Most patients are diagnosed when the cancer has become very large or has spread to other organs. A method to detect pancreatic cancer early on is urgently needed, Dr Zhu said.

My project team aims to develop a blood test to detect pancreatic cancer in the early stages. The team will target exosomes, which are nanosized fragments released by cancer cells. Exosomes are important for communicating messages and transporting materials between cells. Exosomes have been identified as more accurate and promising biomarkers, or biological clues for pancreatic cancer diagnosis, Dr Zhu continued.

We are pleased to award funding to this innovative project, said Michelle Stewart, CEO of the Avner Pancreatic Cancer Foundation. We are encouraged by the high calibre of the research and believe that investment into projects like these will help us to increase survival for people diagnosed with pancreatic cancer.

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World Pancreatic Cancer Day: increasing awareness and inspiring action - UNSW Newsroom

Zoltan Istvan, a Leader in Science and Technology, Will Run for US President and Challenge Trump in the 2020 Republican Primaries – PR Web

Zoltan Gyurko Istvan

SAN FRANCISCO (PRWEB) November 19, 2019

Born in California, Istvan is a former journalist for National Geographic and has recently penned articles for The New York Times opinion section. In 2013, Istvan published his novel The Transhumanist Wager, which became a #1 Philosophy and Science Fiction bestseller on Amazon. The book has been compared more than 1,000 times to Ayn Rands Atlas Shrugged. Istvans most recent book of political essays titled Upgrading America was a #1 bestseller in Politics on Amazon.

Istvan has become known around the world for spearheading the multi-million person transhumanism movement, which aims to upgrade the human body with science and technology. The #1 goal of transhumanism is to overcome biological death. While still outside the political mainstream, the worlds largest companies such as Apple, Google, and Microsoft are key innovators in the transhumanist movement.

Istvan has consulted for the U.S. Navy and given speeches at conferences around the world, including for institutions such as the World Bank and the World Economic Forum. Istvan has traveled to over 100 countries and is a former director of a major wildlife organization, WildAid. He has a degree from Columbia University in Philosophy and Religion. A successful entrepreneur with multiple businesses, Istvan lives in the San Francisco Bay Area with his physician wife and two young daughters.

Istvans 20-point political platform, available on his campaign website http://www.zoltan2020.com, advances ideas that so far have been absent in the Republican primaries. Although his years as a businessman have made him fiscally conservative, Istvan supports a Universal Basic Income that is based off monetizing government resources, called a Federal Land Dividend. He proposes ending the war on drugs, making public preschool and college both free and mandatory, and licensing parents to make sure they are ready to raise children. He supports artificial wombs as a third option in the pro-life vs pro-choice debate, and would like to cut the military budget in order to create a science industrial complex in America. He aims to fight climate change with geo-engineering and end the IRS with a straightforward national sales tax. He favors nearly-open borders, tort reform, deregulation, banning private prisons, and using AI-operated drones and robots to stop mass shootings in public places and schools.

Istvan is also worried that China is beating America on the technological front in areas such as artificial intelligence, genetic editing, and neural prosthetic development. As president, he promises to get America innovating again, because once the Chinese take a lead in innovation, the United States may never get it back.

Pratik Chougule, Istvans campaign manager, says that Istvan is running as a new type of Republican politician. He expects Istvans bold ideas about the countrys future will resonate with a wide cross-section of Americans.

Istvans campaign slogan is: Upgrading America.

For more information, contact campaign manager Pratik Chougule at: pc@zoltan2020.com

To schedule an interview or talk to Mr. Istvan, email: info@zoltanistvan.com or call: 415-802-4891http://www.zoltan2020.comTwitter: @zoltan_istvan

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Zoltan Istvan, a Leader in Science and Technology, Will Run for US President and Challenge Trump in the 2020 Republican Primaries - PR Web

The Most Elaborate Display of Ineptitude I Have Ever Witnessed: The BiChip Hoax – Patheos

The first email was forwarded back and forth internally for a while due to a general sense of skepticism and a lack of clear interest:

From: S E

Date: Fri, Sep 13, 2019 at 1:12 PM

Subject: Bichip Mark of the beast

Hail Satan

Hope you are all fine

I am writing to you since our Human Microchip company is having a big international event here in Copenhagen, November 26th. We are unveiling the cutting edge technology of human microchip implant with long distance read and internet data, for the first time in the history that is also known as the mark of the beast in the bible of Jesus and we have been facing opposition from churches and even been in the news for that:

‘Transhumans’ reveal why they want everyone to implant chips under their skin

Anyway, here is the link to the event is bichip.com/event

I wonder if you guys would like to help us promote the event which is actually free to attend? there are about 400 seats left yet and we can provide free VIP tickets to the temple members (Including free Flight and Accommodation)

Best

Simon

Bichip, Denmark

+4531751127

Professional emails lacking in basic details are, unfortunately, the norm. I receive emails from career journalists at major media outlets sometimes saying nothing more than that they would like to interview me. I get invitations to conferences that merely state that they seek my participation, leaving it to me to ask if they are asking me to speak, seeking sponsorship, or what, exactly? The fact that this email merely asked if we would help promote the event did not make it particularly suspect. The fact that there was apparently no cap set on flights and accommodations, however, was suspect, but could easily be seen as another common failure to specify. If one were to reply, one might then learn that a plus one is acceptable, but no more. It also is not unheard of for a start-up with delusions of grandeur to overspend on something like a conference. Still, they seemed to be offering too much while asking for too little.

Interestingly, the reference to the Mark of the Beast hardly caught my attention at all. Despite the email apparently referring the the biochip as the literal Mark of the Beast, I assumed it a matter of clumsy wording indicating the viewpoint that protestors were taking against the technology, certainly not the viewpoint of the manufacturers themselves. Still, I was not interested. I would not care to get the implant, nor am I horrified by the prospect of others carrying such implants in the future. The technology is not new, it is not terribly interesting, and the alleged controversy seemed a bit outdated in the social media age. In a world wherein nearly everybody willingly submits their most private information to Google and Facebook, and those companies work toward supplying face-recognition technology to public environments for the purposes of instant-tailored marketing, what does it matter if those using e-currency carry it always on their phone, a card in their pocket, or in a chip under their skin?

At some point, I was discussing current issues regarding social media and its regulation with our Ordination Director, Greg Stevens, when I remembered the BiChip email and forwarded it to him. Greg did a cursory investigation and replied to me:

As you know, Im an enthusiastic supporter of transhumanism as an overall direction and love the idea of biotech. Im looking forward to the day we have both the biotech and the AI to provide us with what I call full phenotypic freedom the ability to augment ourselves to be whatever types of creatures we want, and to interface with computer and each other in whatever way we want.

But, based on the material that I saw out there, BiChip is nothing more than a cute initial proof-of-concept in the early stages. Any details of BiChip as a company or its dealings aside, I like that promotion of the BiChip is something that can get the conversation started so that we can confront things like: what does it need to have to be useful? what are the risks and how do we build in protections against those risks from the beginning (instead of stumbling into abuses later and having to fix things after-the-fact).

I would not get the BiChip as its been described. Its simply not useful. I dont make purchases using e-currency in day-to-day life. The only reason something like ApplePay from my iPhone or Apple Watch is useful is that the software can access whatever bank account or credit card I set it up for.

Ive never seen actual whitepapers for BiChip. I saw marketing material, and marketing material is always vague. But based on what I read, BiChip was inherently crippled in that it only operated in ecurrency and was limited in what it could communicate with.

There is no revolution in this tech. The only thing exciting about it is that it was marketed as a product that might get people talking about what biotech may be able to do in the future.

This, of course, led to more in-person discussions and disagreements between Greg and I (I am far more the privacy advocate while he is more for cultivating a cultural adjustment to privacys natural diminishment through technology). Neither of us were against the concept of implants necessarily, though of course they would have to be implanted of ones own free will, without undue coercive influence. For my part, I thought that the very topic of implants might make people begin to look more clearly at the privacy they abdicate daily, finally considering regulation regarding proper usage and retention. We again began to wonder what BiChip was all about, what their event was meant to entail, and how they imagined that we would promote the event.

Over a month had passed from the original email, so I reached out to see if they were still interested in discussing details:

On Wed, 16 Oct 2019 at 07.24,

Dear Simon

We are very interested in the event.

My own position is that Data Privacy is going to necessarily be an ongoing dialogue that will always change as technology advances. I do not think we need to declare privacy dead, but I also do not think that the convenience of a microchip implant poses a deeper threat to privacy than RFID, smartphones, and social media. The question is one of responsible retention and usage of data, not a matter of withholding technologies.

Please let us know if you are still interested in our attendance and how we might help you popularize the event.

Thank you

Lucien Greaves

Spokesperson, Cofounder

The Satanic Temple

The reply came the same day:

Hi Lucien and friends

The offer is still valid and we can provide free vip tickets and free flights and hotel to Denmark for the attendees. However we prefer to have important members/board members as the priority but we can book up to 100 of these tickets.

Regarding the way you help out the event, you can come with any idea. I personally consider myself a member of the temple as i officially joined some years ago and maybe the time and money we are spending on this technology is directly a promotion for the satanist movement I guess it is time that the temple considers Bichip as a partner and help us fight together.

I recommend a direct call to Bichip president (Finn) on 004531751127 or to me 0013232180018 to speed up the process .

Best

Simon

Of course, this did not make any sense to me. An offer to fly some hundred members of The Satanic Temple (TST) to Denmark was grossly improbable even for a delusionally enthusiastic start-up. Further, the email again failed to be explicit in what Bichip would expect from me personally or TST as an organization. I lost interest entirely, but Gregs interest was piqued. Attempting a further investigation into what the whole thing was really about, Greg attempted to contact the numbers provided only to find that they were inoperative numbers. Clearly, none of this was on the level, but it was difficult to understand what exactly the scam was.

On November 08 I received a Direct Message through Twitter, which I never replied to:

I simply forgot about the whole matter.

Then, on November 16, I was tagged in a reply to a bizarre tweet by the same account that had reached out to try and confirm my presence at the international gathering.

This dialogue, I came to discover, was in reference to an article that had just been posted by biohackinfo.com claiming that authorities had raided the Bichip offices for unspecified reasons and that the event I had been invited to was therefore cancelled.

Of course, by now it was clear that the event was never intended to happen to begin with, but it was still unclear what this whole scam was meant to achieve. According to the Biohackinfo article:

Two days ago on November 14, Danish police raided the Copenhagen offices of tech company BiChip. This was three days after we broke the story about BiChips bizarre Chief Technical Officer Simon Sallienjavi, who is also the leader of a growing satanic cult that fuses devil worshiping with biohacking and transhumanism.

With all its operations shut down, BiChip has announced that all its offices are closed until December 29, and they have cancelled their much hyped November 26 event that was to be hosted at the Black Diamond building in Copenhagen. At the event, BiChip was set to unveil what it claims is a revolutionary human microchip implant that is both distance-readable and internet-connectable. Christian groups in Denmark and elsewhere in Europe were planning on protesting this event in part due to Sallienjavis notoriety in Denmark for converting Christians to satanism.

All of this was written without a single citation or hyperlink to any credible source that could confirm any of the claims made. No news articles about the police raid, no hyperlinks outside of those to other articles on the Biohackinfo page itself supporting the claims of Christian uproar, nor anything of any credible nature related to the very existence of Sallienjavi himself. The article went on to make even more extreme claims for which there are no reference anywhere outside of the Biohackinfo site:

Despite Sallienjavis eccentricities, despite his satanic cult, despite the bizarre claims he repeatedly makes in public about being the anti-Christ figure prophesied in the Bible, despite his questionable and borderline criminal activities one of which includes the disappearance of a former cult member named Anna Smolar; Sallienjavi has high level security clearance in many bureaus of the Danish government including Denmarks security services. Sallienjavi also oversees a Danish government-funded multinational called BEZH, which is the parent company of most of his numerous startups, including BiChip.

This was not a conspiracy theory. This was a conspiracy fantasy. The characters do not even exist in the real world. Searches for the story of missing cult member Anna Smolar yield nothing, and Sallienjavi is a fictional character. A significant population of people were credulous enough to believe the PizzaGate conspiracy theory which alleged that a small pizzeria in Washington, DC harbored underground tunnels where political elites engaged in human trafficking, but even that gullible audience (probably) needed at least the pizzeria in question to exist in reality before accepting claims of their covert activities.

The abrupt cancellation of the November 26 event, is going to be met with much anguish and grief from some of the people who were unexpectedly invited like American satanists from both the Church of Satan and the Satanic Temple. The latter in particular, could not wait to attend, and according to our source inside BiChip, Lucien Greaves, the founder of the Satanic Temple, which BiChip has been donating to for years, practically begged Sallienjavi to let him attend the event.

Please let us know if you are still interested in our attendance and how we might help you popularize the event, Greaves had pleaded in an email to Sallienjavi.

Although Sallienjavi wants to absorb both the Satanic Temple and the Church of Satan into his growing cult, he has little to no respect for the Temple and merely regards them as useful idiots and thralls. Sallienjavi however has respect for the Church of Satan, and BiChip had even invited Peter H. Gilmore, the current high priest of the church, to speak at the November 26 event as a secret special guest speaker. BiChip paid Gilmore with 10 bitcoin in advance, a book deal, and $15000 for his flight to Denmark. Gilmore also has an invite to the opening of Sallienjavis cults church.

The most nonsensical part about this, from my perspective, was that the Biohackinfo Twitter account reached out to me directly to taunt me with this article, thus bringing this whole farce to my attention. The claim that BiChip had heavily donated to The Satanic Temple was accompanied by a hyperlink to an image of a document with the TST letterhead at top. The text of the document stated, in embarrassingly poor English, that thanks were in order for the large donations to our church, imploring the donors, Finn and Flemming, to reach out into your network of trans humanists and pull others into the donation circle. The signature read, Kind regards, On behalf of Jacob McKelvy, T.H.

The letter, of course, is a fake, and that is why Biohackinfos enthusiasm in pointing this all out to me was perplexing. Why on earth would anybody create a story so absurd and then immediately send it to somebody who can immediately debunk it? Turns out, Jacob McKelvy is the name of some slob who pretended to be a Satanist for a while only to make a display of converting to Christianity in hopes of marketing himself to Evangelicals. He never had anything to do with TST. It is as though some fool merely Googled Satanist name and went with whatever sounded good at the time. Was Biohackinfo the gullible victim of somebody elses bizarre misinformation campaign? This seems unlikely, as in another article on the Biohackinfo site about the same fictitious Sallienjavi cult, the author writes again of my pleading to attend the international conference stating, This desperate plea by Greaves the self-professed progressive, is despite the fact that in his communication with Sallienjavi, Sallienjavi had made crazy statements to the tune of privacy is dead or privacy should be done away with. In fact, my only communication with the hoax conference (above) expressed my opposition to that perspective, a fact that Biohackinfo revealed to be fully aware of when confronted. When I replied to Biohackinfo, via public tweet, that I was confused by the extreme incompetence in their conspiracy-creation, the Twitter account responded saying, Dont lie followed by an image of my email reply to the hoax conference. And this was not an image of forwarded text from the email. It was clearly an image from the email account itself, indicating that Biohackinfo was in fact the same person behind the conference outreach email to begin with. I am hard-pressed to think of any other time I have seen something so elaborate also be so poorly-thought. This seemed to be the work of somebody who was not terribly bright, who was also quite convinced of their superior intelligence, acting in ways being mistaken for clever toward people who were being mistaken for severely mentally impaired.

Anyway, the fact that Biohackinfo was openly lying about the content of my email reply indicated that they were hardly gullible innocents being misled by another source. However, in a fit of tweets that again indicated the source to be at least partially fooled by the lies they were propagating, Biohackinfo soon began to post screenshots illustrating that they were uploading their files to Wikileaks, apparently believing that this would be of genuine concern to me

The Twitter account also began taunting the Church of Satan (which is actually little more than a Twitter account itself) with screenshots alleging to be a text correspondence with their Magus, Peter Gilmore. Gilmore, according to Biohackinfo, had accepted a speakers fee to deliver a keynote at the conference.

For their part, the Church of Satan denied that the correspondence was legitimate, and it certainly does not approach any reasonable vision of authenticity. For one thing, the correspondence suggests that monies were actually paid, which certainly never happened. Yet, here was Biohackinfo insistently sending these screenshots to the CoS Twitter, revelling in their whistleblower victory. The whole thing grew more confusing by the moment. If somebody is going to make up false accusations, why accuse somebody of something that is not even illegal, nor is it even clearly, in any way, immoral? When I asked Biohackinfo how Gilmore could have been faulted for accepting a speaking gig at the conference, if in reality he had (which he clearly did not), they replied that the effort to produce the literal so called mark of the beast was wrong.

I know that both Peter Gilmore and myself have imposter accounts manifest on a regular basis from Nigerian scammers looking to collect membership fees in our names. Is it possible that Biohackinfo was both trying to constuct an idiotic conspiracy theory about the Mark of the Beast while simultaneously being duped by an imposter Gilmore account? But what about the $15,000? Well, we dont know where the conversation went before or after that, but it looks as though the money was said to be in the mail, and the would-be scammer talking to the hoaxter may well have been skeptical, but what did they have to lose?

Interestingly, the Biohackinfo site is ostensibly a site advocating for Transhumanist agendas the technological augmentation and improvement of human biology but chip implants are a fairly mundane Transhumanist technology, and certainly not one any Transhumanist would be expected to refer to in superstitious fear-mongering language. Is it possible that Biohackinfo is a paranoid, ridiculously inept, religiously superstitious attempt to infiltrate and discredit the Transhumanist movement?

On October 22nd, 2019, the official website of the US Transhumanist Party published an article naming Biohackinfo in the creation of slanderous allegations against them:

The United States Transhumanist Party / Transhuman Party (USTP) unequivocally condemns the false, invented, and malicious allegations contained in two recent articles one by the pseudonymous authors Glyph and CyphR on the yellow-journalism Biohackinfo website, and another by the pseudonymous Nick Sobriquet, published in the Trigger Warning magazine edited by Rachel Haywire. These articles are part of a deliberate, coordinated attack on the transhumanist movement and the many decent, distinguished, accomplished, and benevolent people working within it. These articles also contain numerous outright lies and other half-truths and cherry-picked facts distorted beyond recognition.

The article reveals that the people behind Biohackinfo ran in the recent USTP Electronic Primary, speculating that it was their loss in that election that prompted them to sow chaos and exact vengeance. The Biohackinfo candidate, Rachel Haywire, apparently did not accept her second-place defeat gracefully, prompting the site to fabricate a story in which the USTP was connected to Jeffrey Epstein and intertwined in a massive web of nefarious special interests. Given that the simpletons of Biohackinfo could even make a credible run for the Transhumanist Party candidacy, my guess is that they are not very well connected with any established political players, nefarious or otherwise.

The next day, I received a Direct Message on Twitter from the legendary Sallienjavi himself:

I looked through the feed of the account. No mention of BiChip. Poor English. Various posts about President Trump that can not seem to decide whether the character of Sallienjavi is for him or against him. A few Tweets to indicate Satanism, not to mention he follows 666 accounts and has 666 embedded in his user name. Obviously, Metro.co.uk were duped by a press release when they interviewed Simon, who they then stated only uses his first name and doesnt appear on camera. The account was created in 2012. What kind of deranged fool would maintain this account for this long? Whose bitter antagonism could sustain such prolonged motivation for so long? There were no interactions on any of the posts of this alleged CEO. His followers appear to be nothing but bots and instant follow-backs. Why were these Biohackinfo clowns now messaging me from this account asking me to ignore them? My guess is that they were upset by the way I easily poked holes in their ludicrous story. At one point, the night before, they seemed to be trying to offer an olive branch so as to entice me to desist in my mockery of their infantile scheme:

Shortly thereafter, I received, also via Twitter DM, an unrelated piece of lunacy

And with that, I felt, normalcy had returned. This was a return to pure paranoia the likes of which I regularly receive without flagrant willful and grossly inept attempts at deception.

This Biohackinfo episode is easily the most elaborate and complicated display of absolute ineptitude that I have ever witnessed. I can only assume that they actually think their ploy is clever and that it will somehow prove convincing to a wider audience. They just may even be delusional enough to truly believe that their manufactured revelations will cause as they put it a geopolitical shitstorm, though to what end I can only still just speculate. One would pity them for their troubled idiocy if it were not so visibly stained with antagonistic malice. They created marketing materials for a fictitious product. They created a company and a villainous CEO. They managed to get media to pick up a press release. They manufactured a hoax conference. They put a massive amount of work into a complicated plot that was simultaneously so absurdly poorly-thought.

There is clearly more to this story for anybody who cares to look. That somebody is not presently me, but please let me know what you come up with

Please subscribe to my Patreon page:https://www.patreon.com/LucienGreaves

Follow me on Twitter: @LucienGreaves

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The Most Elaborate Display of Ineptitude I Have Ever Witnessed: The BiChip Hoax - Patheos

What it means to be a cyborg in 2019 – Quartz

I have a four-foot-tall robot in my house that plays with my kids. Its name is Jethro.

Both my daughters, aged 5 and 9, are so enamored with Jethro that they have each asked to marry it. For fun, my wife and I put on mock weddings. Despite the robot being mainly for entertainment, its very basic artificial intelligence can perform thousands of functions, including dance and teach karate, which my kids love.

The most important thing Jethro has taught my kids is that its totally normal to have a walking, talking machine around the house that you can hang out with whenever you want to.

Given my daughters semi-regular use of smartphones and tablets, I have to wonder how this will affect them in the future. Will they have any fear of technologies like driverless cars? Will they take it for granted that machine intelligences and avatars on computers can be their best friends, or even their bosses?

Will marrying a super-intelligent robot in 20 years be a natural decision? Even though I love technology, Im not sure how I would feel about having a robot-in-law. But my kids might think nothing of it.

This is my story of transhumanism.

Courtesy of Zoltan Istvan

My transhumanism journey began in 2003 when I was reporting a story for National Geographic in Vietnams demilitarized zone and I almost stepped on a landmine.

I remember my guide roughly shoving me aside and pointing to the metal object half sticking out of the ground in front of me.

I stared at the device that would have completely blown my legs off had my boot tripped the mine. I had just turned 30. The experience left me shaken. And it kept haunting me.

That night as I lay tense and awake in my hotel room, I had the epiphany that has helped define the rest of my life: I decided that the most important thing in my existence was to fight for survival. To put it another way: My goal was to never die.

Because I was not religious, I immediately turned to the thing that gave meaning to my world: science and technology. I took a leap of faith and made a wager that day. I later called this (and even later, dedicated a book to it) the transhumanist wager.

The life extension business of transhumanism will be a $600 billion industry by 2025.

My idea for an immortality wager came from Pascals Wager, the famous bet that caught on in the 17th century that loosely argued it was better to believe in God than not to, because you would be granted an afterlife if there was indeed a God. My transhumanist wager was based in my belief that its better to dedicate our resources to science and technology to overcome death while were still aliveso we dont ever have to find out whether there is an afterlife or not. It turns out I wasnt alone in my passion to live indefinitely through science. A small social movement, mostly of academics and researchers, were tackling similar issues, starting organizations, and funding research.

Some of them called themselves transhumanists.

Fast-forward 16 years from my landmine incident, and transhumanism has grown way beyond its main mission of just overcoming death with science.

Now the movement is the de facto philosophy (maybe even the religion) of Silicon Valley. It encapsulates numerous futurist fields: singularitarianism, cyborgism, cryonics, genetic editing, robotics, AI, biohacking, and others.

Biohacking in particular has taken offthe practice of physically hacking ones body with science, changing and augmenting our physiology the same way computer hackers would infiltrate a mainframe.

Its pretty obvious why it has emerged as such a big trend: It attracts the youth.

Not surprisingly, worrying about death is something that older people usually do (and, apparently, those younger people who almost step on landmines). Most young people feel invincible. But tell young people they can take brain drugs called nootropics that make them super smart, or give them special eye drops that let them see in the dark, or give them a chip implant that enhances human ability (like the one I have), and a lot of young people will go for it.

In 2016, I ran for the US presidency as the Transhumanist Party nominee. To get support from younger biohackers, my team and I journeyed on the Immortality Busmy 38-foot coffin-shaped campaign busto Grindfest, the major annual biohacking meet-up in Tehachapi, California. In an old dentists chair in a garage, biohackers injected me with a horse syringe containing a small radio-frequency-identification implant that uses near-field communication technologythe same wireless frequency used in most smartphones. The tiny deviceits about the size of a grain of ricewas placed just under the skin in my hand. With my chip, I could start a car, pay with bitcoin, and open my front door with a lock reader.

Four years later, I still have the implant and use it almost every day. For surfers or joggers like myself, for example, its great because I dont have to carry keys around.

One thing I do have to navigate is how some religious people view me once they understand I have one. Evangelical Christians have told me that an implant is the mark of the beast, as in from the Bibles Book of Revelations.

Even though Im tagged by conspiracy theorists as a potential contender for the Antichrist, I cant think of any negatives in my own experiences to having a chip implant. But as my work in transhumanism has reached from the US Military to the World Bank to many of the worlds most well-known universities, my chip implant only exasperates this conspiracy.

While people often want to know what other things Ive done to my body, in reality becoming a cyborg is a lot less futuristic and drastic than people think.

For me and for the thousands of people around the world who have implants, its all about functionality. An implant simply makes our lives easier and more efficient. Mine also sends out pre-written text messages when peoples phones come within a few feet of me, which is a fun party trick.

But frankly, a lot of the most transformative technology is still being developed, and if youre healthy like me, theres really not much benefit in doing a lot of biohacking today.

I take nootropics for better brain memory, but theres no conclusive research I know of that it actually works yet. Ive done some brainwave therapy, sometimes called direct neurofeedback, or biofeedback, but I didnt see any lasting changes. I fly drones for fun, and of course I also have Jethro, our family robot.

For the most part, members of the disabled community are the ones who are truly benefiting from transhumanist technologies today. If you have an arm shot off in a war, its cyborg science that gives you a robot arm controlled by your neural system that allows you to grab a beer, play the piano, or shake someones hand again.

But much more dramatic technology is soon to come. And the hope is that it will be availableand accessibleto everyone.

I asked to be added to a volunteer list for an experiment that will place implants in peoples brains that would allow us to communicate telepathically, using AI. (Biohacking trials like this are secretive because they are coming under more intense legal scrutiny.)Im also looking into getting a facial recognition security system for my home. I might even get a pet dog robot; these have become incredibly sophisticated, have fur softer than the real thing (that doesnt shed all over your couch or trigger allergies) and can even act as security systems.

Beyond that, people are using stem cells to grow new teeth, genetic editing to create designer babies, and exoskeleton technology that will likely allow a human to run on water in the near future.

Most people generally focus on one aspect of transhumanism, like just biohacking, or just AI, or just brainwave-tech devices. But I like to try it all, embrace it all, and support it all. Whatever new transhumanist direction technology takes, I try to take it all in and embrace the innovation.

This multi-faceted approach has worked well in helping me build a bridge connecting the various industries and factions of the transhumanist movement. Its what inspired me to launch presidential and California gubernatorial campaigns on a transhumanist platform. Now Im embarking on a new campaign in 2020 for US president as a Republican, hoping to get conservatives to become more open-minded about the future.

The amount of money flowing into transhumanist projects is growing into many billions of dollars. The life extension business of transhumanism will be a $600 billion industry by 2025, according to Bank of America. This is no time for transhumanism to break apart into many different divisions, and its no time to butt heads. We need to unite in our aim to truly change the human being forever.

Transhumanistsit doesnt matter what kind you arebelieve they can be more than just human. The word natural is not in our vocabulary. Theres only what transhumanists can do with the tools of science and technology they create. That is our great calling: to evolve the human being into something better than it is.

Because transhumanism has grown so broadly by now, not all transhumanists agree with me on substantially changing the human being. Some believe we should only use technology to eliminate suffering in our lives. Religious transhumanists believe we should use brain implants and virtual reality to improves our morality and religious behavior. Others tell me politics and transhumanism should never mix, and we must always keep science out of the hands of the government.

We need unity of some significant sort because as we grow at such a fast rate there are a lot of challenges ahead. For example, the conservative Christian Right wants to enact moratoriums against transhumanism. The anarcho-primativists, led by people like the primitivist philosopher and author John Zerzan (who I debated once at Stanford University), want to eliminate much technology and go back to a hunting-gathering lifestyle which they believe is more in tune with Earths original ecology. And finally, we must be careful that the so-called one percent doesnt take transhumanist technology and leave us all in the dust, by becoming gods themselves with radical tech and not sharing the benefits with humanity.

I personally believe the largest danger of the transhumanist era is the fact that within a few decades, we will have created super-intelligent AI. What if this new entity simply decides it doesnt like humans? If something is more sophisticated, powerful, intelligent, and resilient than humans, we will have a hard time stopping it if it wants to harm or eliminate us.

Whatever happens in the future, we must take greater care than we ever have before as our species enters the transhumanist age. For the first time, we are on the verge of transforming the physical structure of our bodies and our brains. And we are inventing machines that could end up being more intelligent and powerful than we are. This type of change requires that not only governments act together, but also cultures, religions, and humanity as a whole.

In the end, I believe that a lot more people will be on board with transhumanism than admit it. Nearly all of us want to eliminate disease, protect our families from death, and create a better path and purpose for science and technology.

But I also realize that this must be done ever so delicately, so as not to prematurely push our species into crisis with our unbridled arrogance. One day, we humans may look back and revel in how far our species has evolvedinto undying mammals, cyborgs, robots, and even pure living data. And the most important part will be to be able to look back and know we didnt destroy ourselves to get there.

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What it means to be a cyborg in 2019 - Quartz

Hosting vegetarian guests? Make this mushroom dish that even turkey-lovers want to try – INFORUM

The rise of vegetarianism over the past decade means that its likely your guest list will include at least one or more folks who prefer a meatless Thanksgiving. While many vegetarian guests will tell you not to go to any extra trouble, and that theyre happy to graze from the standard variety of vegetable side dishes, we worry that the lack of protein means that they will leave our table still hungry. This simply is not allowed in our food-friendly home, especially on Thanksgiving.

It doesnt take much extra effort to provide a plant-based protein alternative for your veggie-loving guests, and these Caprese-Stuffed Portobello Mushrooms are hearty, delicious and easy to prepare, even in the midst of pre-feast kitchen chaos.

Low in fat, calories and sodium, nutrient-dense portobello mushrooms are a good source of protein, fiber and folate to ensure a full belly, as well as a host of vitamins and minerals believed to help fight cancer, boost the immune system and decrease inflammation. Portobello mushrooms have a wonderful meaty quality in both texture and taste, which makes them popular with vegetarians and carnivores alike.

For this simple dish, youll need four large portobello mushrooms, which are commonly sold in packs of two in most supermarkets. To prepare the mushrooms, remove any remaining stems as well as the dark brown gills to clear space for the caprese stuffing. The gills can be easily removed by gently scraping them with the edge of a spoon.

The gills of portobello mushrooms can be scraped out with a spoon to make room for the caprese stuffing. Michael Vosburg / Forum Photo Editor

Once the inside is prepped, use a damp paper towel to wipe away any dirt from the top and inside of each mushroom. Next, brush each mushroom with a mixture of extra-virgin olive oil, minced garlic, salt and pepper and bake at 400 degrees until soft, about 10 minutes.

Once theyre soft, remove them from the oven and use a paper towel to absorb the excess moisture released in each mushroom. If your available oven time is limited on turkey day, you can refrigerate the mushrooms at this stage for up to one day.

The caprese stuffing is inspired by our wonderful time in Sicily this past summer, which was filled with a bounty of fresh mozzarella cheese and tomatoes. I use fresh mozzarella balls, either pre-marinated or plain, and my favorite variety of flavor bomb cherry tomatoes. Both products can be found in most supermarkets and big-box stores in the Fargo-Moorhead area.

A caprese filling of fresh tomatoes and mozzarella is used to stuff portobello mushrooms. Michael Vosburg / Forum Photo Editor

To flavor the caprese mixture, I use extra-virgin olive oil, a splash of red wine vinegar, a pinch of crushed red pepper flakes and a dash of Sicilian herb seasoning blend (any blend of dried oregano, basil and parsley will do). Each mushroom cap is stuffed with the caprese mixture and baked until the cheese is melted and bubbly, and the tomatoes just begin to blister, about 12 to 15 minutes.

For extra Italian flavor and a pop of color, garnish the mushrooms with thin strips of fresh basil and a drizzle of either balsamic reduction or basil pesto.

With their big flavor, bold colors and high nutrition, these Caprese-Stuffed Portobello Mushrooms are the perfect vegetarian dish for the upcoming holiday season. But, be warned: theyre so attractive and delicious that your turkey-loving guests will probably want a taste, too.

ARCHIVE: Read more Lost Italian columns and recipes

Serves: 4

Ingredients:

4 portobello mushrooms caps, washed and thoroughly dried with paper towel (if purchasing whole, remove the stems and gills)

cup extra-virgin olive oil or canola oil, divided

1 clove garlic, minced

teaspoon kosher salt

teaspoon black pepper

teaspoon red wine vinegar

teaspoon Sicilian or Italian herb seasoning (blend of dried herbs like oregano, parsley and basil)

Pinch of crushed red pepper flakes

1 cup cherry tomatoes, halved

cup fresh mozzarella balls, halved (if using a log of mozzarella, cut into -inch pieces)

2 tablespoons fresh basil, sliced into thin strips (chiffonade), about 4 large leaves

For garnish: Balsamic reduction or basil pesto (optional)

Directions:

Preheat oven to 400 degrees. Line a baking sheet with parchment paper or foil; set aside.

In a small bowl, combine 2 tablespoons of oil with the minced garlic, salt and black pepper. Brush each mushroom all over with the oil mixture, then place on the prepared baking sheet, top side down.

Bake until the mushrooms are soft to the touch, about 9 to 10 minutes. Use a paper towel to soak up the excess moisture inside the mushrooms. The mushrooms can be used immediately or refrigerated at this stage for up to 1 day until ready to finish baking. Bring to room temperature before baking.

As the mushrooms bake: In a medium bowl, use a whisk to combine the remaining 2 tablespoons of oil with the vinegar, herb seasoning and red pepper flakes. Add the tomatoes and mozzarella and gently toss to combine. Taste and add salt and pepper as desired (I use teaspoon of each).

Once the mushrooms are baked until softened, and wiped free of excess moisture, fill the inside of each with the caprese mixture. Return mushrooms to the baking sheet and bake until the tomatoes begin to blister and the cheese is melted and bubbly, about 12 to 15 minutes.

Remove from oven and transfer mushrooms to serving plates or a platter. Generously sprinkle each mushroom with the chopped basil and garnish with a drizzle of reduced balsamic vinegar or basil pesto.

This week in...

Home with the Lost Italian is a weekly column written by Sarah Nasello featuring recipes by her husband, Tony Nasello. The couple owned Sarellos in Moorhead and lives in Fargo with their son, Giovanni. Readers can reach them at sarahnasello@gmail.com.

Originally posted here:
Hosting vegetarian guests? Make this mushroom dish that even turkey-lovers want to try - INFORUM

Vary your veggie options – The Observer

When I decided to become a vegetarian, I knew I had cut my options for accessible and convenient food in half. Most meals feature some sort of meat as the star of the dish, and it can be hard to come by a decent vegetarian option, especially when youre in a rush. And while CWU does have a few options for vegetarian and vegan students, if were being honest, they could be doing a lot better.

According to Forbes, 10% of Americans aged 18 to 29 do not eat meat, with 7% being vegetarian and 3% who are vegan. This is much higher than any of the older age ranges surveyed and shows a trend of college-aged Americans eating less meat. With vegetarianism and veganism on the rise, options on college campuses should reflect the growing demand.

As a senior who lives off campus, Ill admit that I dont eat at the SURC very often. I cant recall many vegetarian options in the dining hall when I was a freshman, but I know that dining has recently expanded their menu to include more meatless dishes. Lately, my experience with vegetarian options at CWU has been grab-and-go options from the Bistro or C-Store. Here, I can find an overpriced bowl of chopped fruit; a protein box with nuts, hummus and veggies; and salads, salads and more salads. While its great that these options are available for students who dont eat meat, eating the same thing over and over can get pretty boring.

With limited meatless options to pick from, I should at least be able to expect my vegetarian meal to actually be vegetarian. Just last week, I picked up a grab-and-go salad from the bistro, clearly marked with a V indicating that it was vegetarian. As I sat down, open my salad and pour on the dressing that was included, I decided to take a peek at the ingredients contained in the dressing. About halfway down the list, I see it: anchovy paste. For me, this was little more than an annoyance. Some people, though, may be allergic or intolerant to an ingredient like anchovies. It can be easy to overlook a minor ingredient like that in a dressing or a side component of the meal. But had I known it wasnt vegetarian, I wouldnt have wasted $6 on the salad in the first place.

I think its awesome that vegetarian options are there, and compared to some other colleges, CWU has plenty to offer in that area. I just think that options could be expanded to include other types of dishes. Instead of a bland salad or mediterranean-style wrap, why not offer something more interesting and flavorful, like curry or a vegan pad thai? There are lots of cultures that have dishes that revolve around plant-based diets, such as Indian, Ethiopian and Thai cuisines. Adding dishes like these would not only bring more flavor to the vegetarian menu at CWU, but also deliver a taste of culture and diversity as well.

Other than the lack of variety, the problem I have with vegetarian options on campus is the lack of protein. Often, when I need to grab a quick bite, I have to opt for some sort of fruit or veggie-based snack with a low amount of protein. Aside from the protein box, the options presented at grab-and-go locations on campus arent the most protein-packed meals. It would be cool to have more meal options that feature beans, chickpeas or even meat alternatives, such as Beyond Meat, as a plant-based protein source.

In the future, as more students start eating less meat and the demand for meatless meals goes up, Im sure options for vegan and vegetarian students will expand. But until then, Ill keep bringing my lunch from home.

Excerpt from:
Vary your veggie options - The Observer

LETTER TO THE EDITOR: A vegetarian diet is a viable choice – BCLocalNews

To the editor,

Re: Its a bit late to demand total plant consumption, Nov. 5.

The columnist asks how veganism would contribute to ecological well-being of humans and other animal species and then concedes that it would achieve immense savings in health costs and reduction in greenhouse gases.

In the north, or on land suitable for pasture but not for crops, I can understand raising animals as a local option. Here in the developed world we tend to build residential suburbs on fine farm land. But to state that shifting to plant diets doesnt take into account global impacts or historical realities sounds very much like the rhetoric of the global corporate capitalism that she decries.

Plant diets can support larger populations than animal diets based on plant inputs. The vegetarian philosophies of Pythagoras of Samos and Gautama Buddha are more than 2,500 years old, and a Scientific American article points to evidence that our ancestors have been primarily vegetarian for 30 million years.

We know that business and political interests prop each other up. Far from being a large-scale action that can only be effected by governments, vegetarianism is a personal decision that can be put into practice every day, and its as down-to-earth as backyard gardening. Anywhere in urban Canada (and especially on Vancouver Island and the Lower Mainland) its easy to find the ingredients for a meal of vegetables made with love.

As Jonathan Safran Foer writes, Choosing leaf or flesh, factory farm or family farm, does not in itself change the world, but teaching ourselves, our children, our local communities and our nation to choose conscience over ease can.

If humans deserve justice, then so do animals.

Ian Poole, Nanaimo

OPINION: Its a bit late to demand total plant consumption

RELATED: New Canada Food Guide nixes portion sizes, promotes plant-based proteins


The views and opinions expressed in this letter to the editor are those of the writer and do not reflect the views of Black Press or the Nanaimo News Bulletin. If you have a different view, we encourage you to write to us or contribute to the discussion below.

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LETTER TO THE EDITOR: A vegetarian diet is a viable choice - BCLocalNews

Testosterone Replacement Therapy Market Report 2019 : Global Analysis and Forecast by 2027 – Eastlake Times

The Testosterone Replacement Therapy Market report is a thorough analysis of the market that offers a detailed assessment of the market situation for the forecast period 2019-2027. The report systematically explains market trends, growth opportunities, challenges, drivers, and other factors impacting the Testosterone Replacement Therapy market. The key focus of the report assists business owners in understanding the market in terms of its segmentation, regional distribution, and influential trends. The report will provide readers a comprehensive analysis of the Testosterone Replacement Therapy market with a broad perspective into the global economy and competitive landscape. The report contains first-hand data of market trends, obtained through rigorous research that can transform the arc of your Business.

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The Testosterone Replacement Therapy report offers the plus points as well as weaknesses of the established market players. It analyses numerous features of the global Testosterone Replacement Therapy market such as demand, drivers, challenges, and options. The report appraises the influence of these aspects on each market region during the estimated time. It presents the value chain analysis together with vendor list and highlights the present market situation between consumer and supplier.

In order to give the users of this report a comprehensive view of the Testosterone Replacement Therapy market, we have included a competitive landscape and an analysis of Porters Five Forces model for the market. The study encompasses a market attractiveness analysis, wherein all the segments are benchmarked based on their market size, growth rate, and general attractiveness.

The years considered to estimate the Insights of Testosterone Replacement Therapy Market are as follows:-

History Year: 2014-2018

Base Year: 2018

Estimated Year: 2019

Forecast Year: 2019 to 2027

Key Highlights of Global Testosterone Replacement Therapy Market Report 2019:

Snaps From the Testosterone Replacement Therapy Report / TOC :

1 Market Overview

1.1 Testosterone Replacement Therapy Introduction

1.2 Market Analysis by Type

1.3 Market Analysis by Applications

1.4 Market Analysis by Regions

North America (USA, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

South America, Middle East and Africa

1.5 Market Dynamics

2 Manufacturers Profiles

3 Global Testosterone Replacement Therapy Market Competition, by Manufacturer

4 Global Testosterone Replacement Therapy Market Analysis by Regions

4.1 Global Testosterone Replacement Therapy Sales, Revenue and Market Share by Regions

(continued)

Ask for the Complete TOC or Any Quiry accepted at:https://www.worldwidemarketreports.com/quiry/106789

10 Global Testosterone Replacement Therapy Market Segment by Type

11 Global Testosterone Replacement Therapy Market Segment by Application

12 Testosterone Replacement Therapy Market Forecast (2019-2027)

13 Sales Channel, Distributors, Traders and Dealers

14 Research Findings and Conclusion

Testosterone Replacement Therapy market will prove as a valuable source of guidance for professional clients like Tier 1, Tier 2, Tier 3 level managers, CEOs, CMOs, as well as interested individual readers across the world. Vendor Landscape provide acts as key development and focus of above professional with common aim to lead the way of Testosterone Replacement Therapy market Worldwide.

If you have any special requirements, please let us know and we will offer you the report as you want.

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Testosterone Replacement Therapy Market Report 2019 : Global Analysis and Forecast by 2027 - Eastlake Times

SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Lipocine Inc. of Class Action Lawsuit and Upcoming…

NEW YORK, Nov. 20, 2019 (GLOBE NEWSWIRE) -- Pomerantz LLP announce that a class action lawsuit has been filed against Lipocine Inc. (Lipocine or the Company) (NASDAQ:LPCN) and certain of its officers. The class action, filed in United States District Court, for the District of Utah, and docketed under 19-cv-00906, is on behalf of a class consisting of investors who purchased or otherwise acquired Lipocine securities between March 27, 2019, and November 8, 2019, both dates inclusive (the Class Period), seeking to recover damages caused by Defendants violations of the federal securities laws and to pursue remedies under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934 (the Exchange Act) and Rule 10b-5 promulgated thereunder, against the Company and certain of its top officials.

If you are a shareholder who purchased Lipocine common shares within the Class Period, you have until January 14, 2020, to ask the Court to appoint you as Lead Plaintiff for the class. A copy of the Complaint can be obtained at http://www.pomerantzlaw.com. To discuss this action, contact Robert S. Willoughby at rswilloughby@pomlaw.com or 888.476.6529 (or 888.4-POMLAW), toll-free, Ext. 9980. Those who inquire by e-mail are encouraged to include their mailing address, telephone number, and number of shares purchased.

[Click here for information about joining the class action]

Lipocine is a specialty pharmaceutical company that focuses on the development of pharmaceutical products in the area of mens and womens health. The Companys primary development programs are based on oral delivery solutions for poorly bioavailable drugs. The Company has a portfolio of product candidates purportedly designed to produce pharmacokinetic characteristics and facilitate lower dosing requirements, bypass first-pass metabolism in certain cases, reduce side effects, and eliminate gastrointestinal interactions that limit bioavailability.

Lipocines lead product candidate is TLANDO (LPCN 1021), an oral testosterone replacement therapy. The Company has previously submitted New Drug Applications (NDA) for TLANDO twice and, both times, received Complete Response Letters (CRL) from the U.S. Food and Drug Administration (FDA) rejecting the NDAs. The Company received the first CRL in June 2016 and the second in May 2018.

On March 27, 2019, during pre-market hours, Lipocine issued a press release announcing new topline results from a study evaluating TLANDOs effects on blood pressure (one issue cited by the FDA in a prior CRL rejecting TLANDOs NDA), as well as the Companys intention to refile the NDA for TLANDO in the second quarter of 2019 (the March 2019 Press Release).

The Complaint alleges that throughout the Class Period, Defendants made materially false and misleading statements regarding the Companys business, operational and compliance policies. Specifically, Defendants made false and/or misleading statements and/or failed to disclose that: (i) the results from Lipocines clinical studies of TLANDO were insufficient to demonstrate the drugs efficacy; (ii) accordingly, Lipocines third NDA for TLANDO was highly likely to be found deficient by the FDA; and (iii) as a result, the Companys public statements were materially false and misleading at all relevant times.

On November 11, 2019, Lipocine issued a press release announcing receipt of a CRL from the FDA regarding its NDA for TLANDO. In the press release, Lipocine advised investors that the FDA had again rejected the NDA for TLANDOthis time because an efficacy trial had not met three of its secondary endpoints.

On this news, Lipocines stock price fell $1.93 per share, or 70.7%, to close at $0.80 per share on November 11, 2019.

The Pomerantz Firm, with offices in New York, Chicago, Los Angeles, and Paris is acknowledged as one of the premier firms in the areas of corporate, securities, and antitrust class litigation. Founded by the late Abraham L. Pomerantz, known as the dean of the class action bar, the Pomerantz Firm pioneered the field of securities class actions. Today, more than 80 years later, the Pomerantz Firm continues in the tradition he established, fighting for the rights of the victims of securities fraud, breaches of fiduciary duty, and corporate misconduct. The Firm has recovered numerous multimillion-dollar damages awards on behalf of class members. See http://www.pomerantzlaw.com.

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SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Lipocine Inc. of Class Action Lawsuit and Upcoming...

INVESTOR ALERT – Lipocine Inc. (LPCN) – Bronstein, Gewirtz & Grossman, LLC Notifies Investors of Class Action and Lead Deadline: January 14, 2020…

NEW YORK, NY / ACCESSWIRE / November 20, 2019 / Bronstein, Gewirtz & Grossman, LLC notifies investors that a class action lawsuit has been filed against Lipocine Inc. ("Lipocine" or the "Company") (LPCN) and certain of its officers, on behalf of shareholders who purchased Lipocine securities purchased between March 27, 2019, and November 8, 2019, both dates inclusive. Such investors are encouraged to join this case by visiting the firm's site:www.bgandg.com/lpcn.

This class action seeks to recover damages against Defendants for alleged violations of the federal securities laws under the Securities Exchange Act of 1934.

The complaint alleges that throughout the Class Period, defendants made false and/or misleading statements and/or failed to disclose that: (1) the results from Lipocine's clinical studies of TLANDO were insufficient to demonstrate the drug's efficacy; (2) accordingly, Lipocine's third NDA for TLANDO was highly likely to be found deficient by the FDA; and (3) as a result, the Company's public statements were materially false and misleading at all relevant times.

On November 11, 2019, Lipocine announced receipt of a Complete Response Letter ("CRL") from the U.S. Food and Drug Administration regarding its New Drug Application for TLANDO, Lipocine's product candidate for testosterone replacement therapy. Lipocine advised investors, inter alia, that "[t]he CRL identified one deficiency stating the efficacy trial did not meet the three secondary endpoints for maximal testosterone concentrations." On this news, Lipocine's stock price fell sharply during intraday trading on November 11, 2019.

If you wish to review a copy of the Complaint you can visit the firm's site: http://www.bgandg.com/lpcn or you may contact Peretz Bronstein, Esq. or his Investor Relations Analyst, Yael Hurwitz of Bronstein, Gewirtz & Grossman, LLC at 212-697-6484. If you suffered a loss in Lipocine you have until January 14, 2020 to request that the Court appoint you as lead plaintiff. A lead plaintiff acts on behalf of all other class members in directing the litigation. The lead plaintiff can select a law firm of its choice. Your ability to share in any recovery doesn't require that you serve as a lead plaintiff.

Bronstein, Gewirtz & Grossman, LLC is a corporate litigation boutique. Our primary expertise is the aggressive pursuit of litigation claims on behalf of our clients. In addition to representing institutions and other investor plaintiffs in class action security litigation, the firm's expertise includes general corporate and commercial litigation, as well as securities arbitration. Attorney advertising. Prior results do not guarantee similar outcomes.

Contact:

Bronstein, Gewirtz & Grossman, LLCPeretz Bronstein or Yael Hurwitz

212-697-6484 | info@bgandg.com

SOURCE: Bronstein, Gewirtz & Grossman, LLC

View source version on accesswire.com: https://www.accesswire.com/566989/INVESTOR-ALERT--Lipocine-Inc-LPCN--Bronstein-Gewirtz-Grossman-LLC-Notifies-Investors-of-Class-Action-and-Lead-Deadline-January-14-2020

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INVESTOR ALERT - Lipocine Inc. (LPCN) - Bronstein, Gewirtz & Grossman, LLC Notifies Investors of Class Action and Lead Deadline: January 14, 2020...

Global Testosterone Replacement Therapy Market Forecast, by regions, type and application, with sales and revenue, from 2019 to 2024. – Med News…

According to a latest report published by Global Marketers Biz named as Testosterone Replacement Therapy Market offers data for the forecast period 2019-2024. A comprehensive research updates and data which includes following key aspects for the global Testosterone Replacement Therapy Market in terms of volume and revenue Visitor Demographics, Facility Size, Demand & Growth Opportunities, Global Industry Forecast Analysis and Revenue Source.

The Testosterone Replacement Therapy Market report offers in-depth analysis and insights into developments impacting businesses and enterprises on global & regional level. A detailed breakdown of key trends, drivers, restraints, and opportunities influencing revenue growth is presented in this research report. This study focuses on the global Testosterone Replacement Therapy market by share, volume, value, and regional appearance along with the types and applications.

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Global Testosterone Replacement Therapy Market Forecast, by regions, type and application, with sales and revenue, from 2019 to 2024. - Med News...

New Database Could Help Identify Therapeutic Targets for the Creation of Antibiotics – Technology Networks

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonising and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood. This is highly relevant given the fact that the development of new antimicrobial therapies is largely based on current knowledge of the mechanisms behind these infections. The proteins coded by the bacterial genes are responsible for the thousands of biochemical processes essential for the efficient propagation of the pathogen. Many studies demonstrate, however, that in order to identify these genes, in vivo information is needed on what happens with the bacteria in a real case of an infected host. The in vitro studies, i.e., those recreated in laboratories with cell and bacterial cultures, later do not always correlate with data from in vivo studies. This is due to the fact that pathogenic bacterial genes essential for producing the infections depend on the environment of the colonised organism.A team of researchers from the Department of Biochemistry and Molecular Biology of the Universitat Autnoma de Barcelona and from the Centre of Genomic Regulation (CRG) has created the BacFITBase database. Based on the results of the in vivo experiments, researchers systematically characterised the bacterial genes relevant for host cell invasion and infection. All the experiments performed were based on a technique named transposon mutagenesis, where the DNA fragments called transposons are transferred to the organism's pathogenic genes, thereby inactivating them. By doing so, their role in the infection can be observed directly and researchers can determine which are essential for a specific host organism to become infected. Therefore, this database will make it easier to identify target proteins that can help in fighting infectious diseases and accelerate the development of new antimicrobial agents.The database contains over 90,000 entries with information on specific pathogenic bacterial genes and their contribution to in vivo infectious conditions in five different host species. It includes information on a total of 15 bacteria (two variants ofSalmonella enterica, Haemophilus influenzae, Streptococcus pyogenes, Porphyromonas gingivalis, Mycobacterium avium,three variants ofEscherichia coli, Vibrio cholerae, Campylobacter jejuni, Klebsiella pneumoniae, Acinetobacter baumannii, Serratia marcescensandVibrio parahaemolyticus) and 5 model vertebrates (cow, pig, hen, mouse and rabbit), with information across 10 different tissues.BacFITBase, published in the journal Nucleic Acids Research, was developed by researchers from the UAB Department of Biochemistry and Molecular Biology Javier Macho and Marc Torrent, alongside researchers from the Centre for Genomic Regulation (CRG) Benjamin Lang and Gian Gaetano Tartaglia.

Reference:Rendn,et al. (2019) BacFITBase: a database to assess the relevance of bacterial genes during host infection.Nucleic Acids ResearchDOI: https://doi.org/10.1093/nar/gkz931

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Database Could Help Identify Therapeutic Targets for the Creation of Antibiotics - Technology Networks

Longhorn Stop the Bleed receives 5 years of funding to expand emergency response training – UT The Daily Texan

The previously unfunded Longhorn Stop the Bleed program recently received five years of funding from Campus Safety and Security.

The program is a chapter of a national organization created after Sandy Hook to teach people how to respond in bleeding emergencies. UT alumna Claire Zagorski said she started a chapter of the program on campus to reduce fatality and helplessness.

I was inspired to bring it to UT after Harrison Brown was stabbed to death, program director Zagorski said. The bystander was saying, This is terrible because he was laying there bleeding and no one could do anything, just wait. Im a paramedic, and I knew that wasnt true, but I also knew people had to be taught what to do.

Zagorski said the funding will consist of $2,500 every year and is the result of safety advocacy nonprofit SafeHorns stressing the programs importance to Campus Safety and Security.

It was very validating, Zagorski said. Im glad that the work that were doing is getting noticed and that were making a difference, and now were going to be able to take a big step forward in expanding the program because of that.

Zagorski said the program will use the funds to buy more training equipment for larger classes and to launch a promotional campaign to increase awareness. She said the training is useful in many contexts, but people pay attention to the program if they see a recent uptick in campus violence.

UT is an open campus, biochemistry sophomore Sonia Patel said. I think its a necessity for people, and students especially, to be aware of what to do in the event of a shooting or stabbing. If we were aware of it, we could help save people.

Zagorski said the program partners with the certified EMTs in Longhorn EMS to lead training courses. David Wu, lead instructor of Longhorn Stop the Bleed in Longhorn EMS, said empowerment is a huge goal of the training.

It isnt necessarily having the skills, biochemistry junior Wu said. Its having the confidence of knowing you have the training to know what to do in that scenario. Most bystanders are in shock when something happens, and with a little training, it gives you a bit of confidence to go, Okay, I know what to do in this situation. This is how I should move forward.

Link:
Longhorn Stop the Bleed receives 5 years of funding to expand emergency response training - UT The Daily Texan

Missing Leonardo link: writer discovers that Da Vinci’s anatomy drawings were owned by Charles II – Art Newspaper

The incomparable Leonardo volume (around 1590) that provided the exciting proof of provenance Courtesy of Royal Collection Trust

Were the wonderful Leonardo drawings at Windsor once owned by Charles II? Scholars have been intrigued by the idea, but there has been no proof. Their earliest documentation in the Royal Collection dates from 1690, when Constantijn Huygens Jr, secretary to William III, spent a morning leafing through the bound album. So, when I stumbled on a report in an English publication of 1680, it was not so much eureka! as gotcha!. Here, unmistakably, was an eyewitness account of Leonardos drawings being in Charles IIs Whitehall Cabinet.

The testimony came from a blue-chip sourceWalter Charleton (1619-1707), physician-in-ordinary to Charles I and Charles II. Prominent in his own day, he is now eclipsed by more famous friends, John Evelyn, Anthony Wood and Margaret Cavendish. In March 1679, as Harveian Orator of the Royal College of Physicians, Charleton gave the inaugural lectures in the new anatomy theatre. These were published in 1680 as Enquiries Into Human Nature: in VI. Anatomic Praelections in the New Theatre of the Royal Colledge of Physicians in London. The opening words of the sixth lecture, Of motion voluntary, are startling:

For Painting, I recommend to them the incomparable Lionardo da Vinci, della Pittura: not only because he was eminently skilld in all parts of Anatomy, as appears by the accurate Figures that illustrate and adorn Vesaliuss noble Volume De Corporis humani fabrica, all of which were drawn and cut by Da Vincis own hands; and the original Draughts of which are yet extant in a large Manuscript of his in Folio, in the Italian language (but written from the right hand to the left) carefully preservd in HisMajesties Cabinet at White-Hall, where I have had the good fortune sometimes to contemplate them: but alsobecause in his Treatise Della Pittura just now mentiond, he seems to me to have describd the figures, motions, forces and symmetry of the limbs, their Articulations and Muscles, in various postures, more clearly than any Writer I have hitherto read.

Charletons intimate contact with the Leoni-Leonardo album is palpable, and felicitous; we could scarcely conjure a more fitting 17th-century English reader. Discussing Leonardos writings on animal and human musculature, he cites a passage in the editio princeps (Paris, 1651) of the artists Trattato della pittura. To identify a text that confirms Charles IIs ownership of the album during the 1670s connects Leonardos anatomydrawings and the treatise on painting, and situates them in the frontline of 17th-century scientific theory, was, for a Leonardo nerd like me, equivalent to finding the missing evolutionary link. The new discovery holds out the promise of further eureka moments among the papers of Charletons networks, and a glimmer of hope that we may yet ascertain how Leonardos celebrated drawings entered the Royal Collection.

Margaret Dalivalles discovery is discussed in more detail in Leonardos Salvator Mundi and the Collecting of Leonardo in the Stuart Courts, published on 17 October by Oxford University Press. She teaches at the Centre for Medieval and Renaissance Studies, Oxford

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Missing Leonardo link: writer discovers that Da Vinci's anatomy drawings were owned by Charles II - Art Newspaper