Rare leukemia targeted by modifying patients’ immune cells – New Haven Register

Photo: Arnold Gold / Hearst Connecticut Media

Dr. Steven Gore at the Advanced Cell Therapy Lab at Smilow Cancer Hospital in New Haven, where cells are manufactured that fight a rare form of leukemia.

Dr. Steven Gore at the Advanced Cell Therapy Lab at Smilow Cancer Hospital in New Haven, where cells are manufactured that fight a rare form of leukemia.

Rare leukemia targeted by modifying patients immune cells

NEW HAVEN >> Young patients with a particular type of leukemia who have relapsed after going into remission may find new hope through a treatment that involves modifying a patients own T cells, an important part of the immune system, to destroy cancer cells.

While the therapy, in which genes are inserted into a patients T cells, is expected to receive Food and Drug Administration approval soon for pediatric patients, researchers hope that it will be effective for adult patients as well and for more types of cancers, according to Dr. Steven Gore, director of hematologic malignancies at the Yale Cancer Center.

The cancer thats the focus of this T cell therapy is B-lineage acute lymphoblastic leukemia, which is the most common leukemia in kids and its commonly cured in the 2- to 10-year-old age group, Gore said. He said about 70 percent of children with the cancer are cured.

However, the rest suffer a recurrence of the disease even after treatment with chemotherapy and stem cell transplants.

Its getting to be a difficult situation, Gore said.

There are 3,100 cases of children with B-lineage ALL each year, he said.

B cells, also known as B lymphocytes, are white blood cells that produce antibodies, which fight infection. A characteristic of B cells is that they have a protein on their surface called CD19, which is the key to the new treatment.

The new process, marketed by Novartis and first developed at the University of Pennsylvania, involves harvesting T cells from the patient. Novartis then introduces DNA into these T cells, introducing new genes into the T cells, [which] include a receptor that will recognize CD19, Gore said. The genes that are fused into the T cells are manufactured in the lab but are copies of normal human genes, Gore said. The new cell is called a chimeric antigen receptor T cell, or CAR-T cell.

Normal T cells fight disease, and we know that T cells can attack cancer cells as well, but getting them to do so in the host where the cancer has developed is tricky, Gore said. Cancer cells are very similar [to] normal cells from which they derive.

Turning the T cells into CAR-T cells helps by targeting the CD19 marker on the B cells. CD19 happens to be a pretty good target for cancer technology because its only on B cells, Gore said. These new CAR-T cells latch onto the leukemia cells.

Reproducing cells

Then, once they see that theyre needed, the CAR-T cells are going to make more of themselves. Theyre going to make a whole army-full beside what we gave the patient, Gore said. Other genes in the introduced DNA give the immune system the go-ahead to kill these leukemia cells.

The CAR-T cells target both healthy and malignant B cells, but people live all the time without B cells, Gore said, by relying on drugs such as rituximab.

The treatment is not easy on the patient, however. When this massive influx of these new T cells attack all these leukemia cells, youre basically setting up a jihad in your body, Gore said. People can get very critically ill after this therapy, even needing to be treated in the intensive care unit.

Despite the hardship, the FDAs Oncologic Drugs Advisory Committee voted 10-0 on July 12 to recommend approval of CAR-T therapy, and it is very rare that an ODAC approval does not end up in an FDA approval, Gore said.

In one trial, 41 of 50 patients with relapsed or refractory B-lineage ALL each achieved complete remission after three months, Gore said, and 60 percent of those patients were still in remission six months later.

It will be rapidly opened up to adults as well, theres no question about it, he said. Some people think this therapy may replace stem cell therapy and doctors hope it can be given before a patient relapses, avoiding stem cell transplants.

We dont have long-term follow-up to know if these patients are cured, Gore said. Theyve certainly been rescued from otherwise-certain death.

Gore said the Yale School of Medicine has been approached by Novartis to be one of the rollout sites for this therapy.

While the new treatment targets a relatively rare cancer, its likely to be effective in other cancers involving B cells, including other types of leukemia and lymphoma, Gore said. (Not all lymphomas and leukemias are B cell cancers, however.) This rare leukemia has been the subject of all this investigation because CD19 is such a low-hanging fruit, because we can live without B cells, he said.

But the technology can theoretically be adapted to any kind of tumor, he said. Theoretically, you could make a CAR-T to target any particular kind of cancer provided that that cancer expresses certain proteins that are predominantly limited to the cancer and not important vital organs.

Call Ed Stannard at 203-680-9382.

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Rare leukemia targeted by modifying patients' immune cells - New Haven Register

Resident warrior: When life was about spirituality – Bangalore Mirror

By SN Krishna Swamy

I was born in Malleshwaram, Bengauru, in 1926. Now, I am 91. I did my schooling in Malleshwaram and thereafter pursued Physics honours and MSc in Central College, Bangalore, Mysore University. In 1948, I joined Vijaya college as a Physics lecturer and then shifted residence to Gavipuram extension. After living in six different rented houses in Bangalore, we built a house in Basappa layout in the same neighbourhood. The location is so central and just a kilometre away from Gandhi Bazar, a good shopping centre, and Vidhyarthi bhavan, justly famous for its masala dosas.

My house is right at the foot of the Harihara hillock, whose peak stands the Harihara Temple aad right next to my house I have an attached milk booth, a vegetable shop and a park. Regular morning and evening walks in the park form part of our regular routine, where we also have a cultural group called Sneha Ranga which has close to 200 members from the neighbourhood. We all meet when there are important occasions.

For me, however, the main attraction is the Ramakrishna Math. Three successive presidents of the ashrama were spiritual giants namely, Swami Tygaishwarananda, Swami Yatiswarananda and Swami Prabhudananda. I have been under the influence of Ramakrishna and Vivekananda culture as well as and that of Mahatma Gandhi since childhood. I chose to be brahmachari all through life while I pursued interests such as singing bhajans. This tradition I taught to the children of Vivekananda Balaka Sangha and to groups of young men and women. Even now I conduct Bhajan classes at the Indian Institute of World culture in Gandhi Bazaar. I am proud to say that a few children at the Balaka Sangha have become renowned members of the Ramakrishna Order.

I built my house using granite in 1970-1971. I also worked in the Army headquarters as a scientist after 1975 and in Pune as a professor of college of Military Engineering. When I retired in 1982, my young friends in Vivekananda school and Vivekananda Sevashrama, a renowned medical service, persuaded me to work with them. Last year, I resigned as the president at these institutions. I also did four foreign tours to raise funds through Bhajan concerts for the charitable institutions. On August 5, I was speaking at a study circle at Suchitra Film Society on Champaran Satyagraha.

What I see since 1926 to 2017 is a lot more freedom to do what we want in life. I am so happy to see youngsters enjoying the fruits of our labour. We will be celebrating our 70th year of independence soon and I am proud to see it alive.

(The author is a resident of Gavipuram)

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Resident warrior: When life was about spirituality - Bangalore Mirror

Letter: Our forests are sacred – Kelowna Capital News – Kelowna Capital News

To the editor:

I realize that I might be barking up the wrong tree and that the idea I am proposing might be no more than the midnight ramblings of an old man, but I think perhaps, the time has come for an evolutionary concept.

Given that a great number of our community members find some form of spiritual enlightenment within our watershed, and that this watershed is also home to many of the creatures and plants that we hold dear, and given the extremely sensitive balance that occurs here and that is unique and vital to our happiness and even our survival, and given also that water is held in such regard that it is akin to life itself and given that life is held sacredly a vast majority of people, should not the source of our water, our watershed, be given a designation appropriate to its greater value.

For centuries, we have treated our forests like disposable commodities. Some values, once lost, cannot be replaced.

I therefore call on people who care, to institute for our watershed, the designation of Sacred Forest and apply to it the appropriate protections.

Joe Klein for the Peachland Watershed Protection Alliance

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Letter: Our forests are sacred - Kelowna Capital News - Kelowna Capital News

Africa has entered the space race, with Ghana’s first satellite now orbiting earth – TechCrunch

The GhanaSat-1Ghanas first satellitebegan its orbit recently, with a little help from some friends.

The cubesat, built by a Ghanaian engineering team at All Nations University, was delivered to NASAs International Space Station in June on a SpaceX rocket that took off from pad 39a at Kennedy Space Center, a NASA spokesperson confirmed.

The GhanaSat-1 deployed into orbit from the Center in July, and is now operational, according to project manager Richard Damoah, a Ghanaian professor and assistant research scientist at NASA.

This particular satellite has two missions, Damoah told TechCrunch. It has cameras on board for detailed monitoring of the coastlines of Ghana. Then theres an educational piecewe want to use it to integrate satellite technology into high school curriculum, he said.

GhanaSat-1 will send a signal to a ground station at All Nations Universitys Space Systems and Technology Laboratory. Thats where it was developed by a team of engineers that included Benjamin Bonsu, Ernest Teye Matey, and Joseph Quansah.

While Ghanas president Nana Akufo-Addo applauded the launch and congratulated the team directly, the project did not receive official Ghanaian government support, according to Damoah. Instead, Japans national space agency, JAXA, provided the bulk of the resources and training to develop the satellite.

The GhanaSat-1 deployment marks increased interest and activity in Africa toward space exploration. Nigerias first cubesat launched on the same SpaceX mission. Several nations, such as South Africa, Nigeria, Kenya and Ethiopia have space agencies. Angola announced its intention to launch a satellite over the coming year, said Elsie Kanza, Head of Africa at the World Economic Forum.

She also pointed to Pan-African efforts to coordinate space efforts, such as the African Unions African Space Policy and Strategy initiativeadopted last yearthat prompted AU members states to realize an African Outer space Programme, as one of the flagship programmes.of the AU Agenda.

Damoah believes the GhanaSat-1 deployment could prompt Ghanaian government resources toward a second satellite project coordinated by All Nations University and the countrys Science Space and Technology Center. After this launch, we now have the support of the president and cabinet support, he said. We are looking to develop a GhanaSat-2, with high resolution cameras, that could monitor things such as illegal mining, water use, and deforestation in the country.

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Africa has entered the space race, with Ghana's first satellite now orbiting earth - TechCrunch

Hubble spots exoplanet with glowing water atmosphere – SpaceFlight Insider

Jim Sharkey

August 6th, 2017

This artists concept shows hot Jupiter WASP-121b, which presents the best evidence yet of a stratosphere on an exoplanet. Image & Caption Credit: Engine House VFX, At-Bristol Science Centre, University of Exeter

Researchers working with data from NASAs Hubble Space Telescope have found the strongest evidence to date for the existence of a stratosphere the layer of an atmosphere in which temperature increases with altitude on an exoplanet (a planet outside of the Solar System). The new study was published in the August 3, 2017, issue of the journal Nature.

This result is exciting because it shows that a common trait of most of the atmospheres in our solar system a warm stratosphere also can be found in exoplanet atmospheres, said Mark Marley, the studys co-author who is based at NASAs Ames Research Center. We can now compare processes in exoplanet atmospheres with the same processes that happen under different sets of conditions in our own solar system.

The researchers studied WASP-121b, an example of a type of exoplanet called a hot Jupiter. The planets mass is 1.2 times the that of Jupiter and its radius is 1.9 times Jupiters. Wasp-121b is much closer to its star than Jupiter is to the Sun. While it takes Jupiter 12 years to revolve once around the Sun, WASP-121 orbits its star once every three days. If the exoplanet were any closer to its star, the stars gravity would rip it apart. WASP-121s atmosphere is heated to 4,600 degrees Fahrenheit (2,500 degrees Celsius), hot enough to boil some metals.

An earlier studyfound possible signs of a stratosphere on the exoplanet WASP-33b and other hot Jupiters. The new study provides the strongest evidence yet because scientist observed the signature of hot water molecules for the first time.

Theoretical models have suggested stratospheres may define a distinct class of ultra-hot planets, with important implications for their atmospheric physics and chemistry, said Tom Evans, lead author and research fellow at the University of Exeter, United Kingdom. Our observations support this picture.

The scientists studied the atmosphere of WASP-121 by using Hubbles spectroscopy capabilities to analyze how different molecules react to specific wavelengths of light. For example, water vapor in the planets atmosphere behaves in predictable ways depending on the temperature of the water.

The top of the planets atmosphere is heated to a blazing 4,600 degrees Fahrenheit (2,500 Celsius), hot enough to boil some metals. Image & Caption Credit: NASA, ESA, and G. Bacon (STSci)

A stars light can penetrate deep into a planets atmosphere, raising the temperature of the gas there. The gas then radiates its heat into space as infrared light. If there is cooler water vapor at the top of the atmosphere, the water molecules will block certain wavelengths of light from escaping into space. If, however, the water molecules at the top of the atmosphere have a higher temperature, they will glow at the same wavelengths.

The emission of light from water means the temperature is increasing with height, said Tiffany Kataria, the studys co-author based at NASAs Jet Propulsion Laboratory, Pasadena, California. Were excited to explore at what longitudes this behavior persists with upcoming Hubble observations.

In Earths stratosphere, ozone gas traps ultraviolet radiation from the Sun, raising the temperature of this layer of the atmosphere. Other bodies within the Solar System also have a stratosphere. For example, methane is responsible for heating the stratospheres of Jupiter as well as Saturns moon Titan.

In planets of the Solar System, the change in temperature within a planets stratosphere is approximately 100 degrees Fahrenheit (about 56 degrees Celsius). On WASP-121b, the temperature in the stratosphere rises by 1,000 degrees Fahrenheit (560 degrees Celsius). Researchers do not yet know which chemicals are responsible for the temperature in WASP-121bs atmosphere. Vanadium oxide and titanium oxide are possible candidates because they are commonly found in brown dwarfs failed stars that share some characteristics with exoplanets. Compounds such as these are expected to be found on only the hottest of hot Jupiters because high temperatures are required to keep them in a gaseous state.

This super-hot exoplanet is going to be a benchmark for our atmospheric models, and it will be a great observational target moving into the Webb era, said Hannah Wakeford, the studys co-author who worked on this research while at NASAs Goddard Space Flight Center, Greenbelt, Maryland.

Video courtesy of NASA

Tagged: Ames Research Center exoplanet Hubble Space Telescope NASA The Range

Jim Sharkey is a lab assistant, writer and general science enthusiast who grew up in Enid, Oklahoma, the hometown of Skylab and Shuttle astronaut Owen K. Garriott. As a young Star Trek fan he participated in the letter-writing campaign which resulted in the space shuttle prototype being named Enterprise. While his academic studies have ranged from psychology and archaeology to biology, he has never lost his passion for space exploration. Jim began blogging about science, science fiction and futurism in 2004. Jim resides in the San Francisco Bay area and has attended NASA Socials for the Mars Science Laboratory Curiosity rover landing and the NASA LADEE lunar orbiter launch.

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Hubble spots exoplanet with glowing water atmosphere - SpaceFlight Insider

‘My sister says I am an alien’: A 9-year-old applies to be NASA’s planetary protection officer – Washington Post

When NASA announced last week that it was looking for a new planetary protection officer, the space agency received some incredulous responses.

Some were agog at the six-figure salary: between $124,000 and $187,000 per year. Others laughed at the fantastical job title, one that conjured up science-fiction fantasies and battles with aliens. (In reality, NASA says, theposition is focused on preventing astronauts from bringing biological contaminants from space back to Earth and vice versa.)

But one 9-year-old boy in New Jersey took the vacancy seriously.So he took a sheet of paper and an obviously well-sharpened pencil and carefully hand-wrote his application.

Dear NASA, My name is Jack Davis and I would like to apply for the planetary protection officer job, Jack wrote. I may be nine but I think I would be fit for the job.

Among his qualifications? For one, he wrote, his sister says he's an alien. Jack also said he had watched the TV show Marvel Agents of S.H.I.E.L.D. and almost all the space and alien movies I can thoughnot yet Men in Black. (In Jack's defense, the 1997 hit movie with Will Smith and Tommy Lee Jones came out more than a decade before hewas even born.)

Toward the end of his letter, Jack casually mentions that he is great at video games. But his final assertion is perhaps the most persuasive.

I am young, so I can learn to think like an alien, Jack wrote.

He signed off with his name and appended it with Guardian of the Galaxy and Fourth Grade.

Jack soon got that simple yet elusive thing every jobseeker wants: confirmation that his application had been received. James L. Green, director of NASA's Planetary Science Division, wrote back tohimright away.

I hear you are a 'Guardian of the Galaxy' and that you're interested in being a NASA Planetary Protection Officer, Green wrote. That's great!

He also took the time to dispel any myths about what the job entailed.

It's about protecting Earth from tiny microbes when we bring back samples from the Moon, asteroids and Mars. It's also about protecting other planets and moons from our germs as we responsibly explore the Solar System.

In short, it's light on the alien encounters. But Green signed off on an encouraging note, telling Jack to study hard and do well in school so that they could see him at NASA eventually. As a bonus, Jack also received a phone call from NASA'sheadquarters in Washington to congratulate him on his interest.

At NASA, we love to teach kids about space and inspire them to be the next generation of explorers, Green said in a statement. Think of it as a gravity assist a boost that may positively and forever change a person's course in life, and our footprint in the universe.

Jack told ABC Newsthat it would be really cool to work for NASA.

I feel like I am the only one who really wants a job at NASA this young, he told the news station.

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'My sister says I am an alien': A 9-year-old applies to be NASA's planetary protection officer - Washington Post

New NASA Visualization Shows Where This Month’s Solar Eclipse Will Be Visible – Futurism

In BriefA new visualization from NASA shows how the moon's irregularshape will influence where the upcoming solar eclipse will bevisible. Simulating Shadows

On August 21, a swatch of Earth residents will witness the rare side effect of our planets long dance with its oldest partner: a total solar eclipse, caused by the perfect alignment of the Moon in front of the sun.

A new visualization from NASA shows in extraordinary detail where the total eclipse will be visible; primarily along an approximately 112 km (70 mile) stretch, cutting across the United Statesdiagonally from Oregon to South Carolina. This diagonal lies in the path of the umbra, the part of the Moons shadow where the sun is entirely blocked by the Moon.

The visualization shows that the umbra is shaped like an irregular, slightly curved polygon, rather than the circle you might expect. The same dips and bumps that shade faces and imaginary seas into the Moons surface also affect how light passes around it.

With this new visualization, we can represent the umbral shadow with more accuracy by accounting for the influence of elevation at different points on Earth, as well as the way light rays stream through lunar valleys along the moons ragged edge, said NASA visualizer Ernie Wright of Goddard Space Flight Center in Maryland.

This new level of detail comes from pairing 3-D maps of the Moons surface, created by NASAs Lunar Reconnaissance Orbiter, with elevation data for the places its shadow will hit.

Because the umbral shadow is relatively small, a solar eclipse is only visible somewhere on Earth roughly every 18 months.

So, if you find your area in the path of totality one year, youve hit the jackpot, NASA officials explain in the video above.Because on average, that same spot on Earth will only get to see a solar eclipse every 375 years.

However, this already rare phenomenon is getting evenmore so:the Moon exerts a pull on the earth that creates ocean tides, and subsequentlyslows our planets rotation.This also transfers energy into the Moons orbit that pushes it away from Earth.

As a result, our Moon recedes by about 1.48 inches every year roughly the same speed at which your fingernails grow. Someday, it will be too far to block the sun fully.

Over time, the number and frequency of total solar eclipses will decrease, explains Richard Vondrak, a lunar scientist at NASAs Goddard, in the statement. About 600 million years from now, Earth will experience the beauty and drama of a total solar eclipse for the last time.

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New NASA Visualization Shows Where This Month's Solar Eclipse Will Be Visible - Futurism

NASA’s ‘Planetary Protector’ on What Everyone Gets Wrong About Her Job – Fortune

Catharine "Cassie" Conley, NASA's current Planetary Protection Officer. Photo by W. Hrybyk, NASA-GSFC

When NASA announced this week that the space agency was searching for a new "planetary protection officer," the internet went crazy over the six-figure position that sounded like something from out of this world. Headlines touted the role as a "job opening for someone to defend Earth from aliens" and memes followed closely behind.

The widespread attention and misunderstanding of what the job entailed surprised Catharine "Cassie" Conley, NASA's current planetary protection officer, who has held the position since 2006. She's glad to see people talking about NASA's work, but wants to set the record straight: Her job is to protect both Earth and other planets from disease-causing microbes, not sentient beings.

"We have no evidence that there has been an invasion of intelligent life," Conley told Fortune in an interview on Friday. She declined to say whether she is leaving her job or plans to apply to the new version NASA listed. She is the sixth planetary protection officer NASA has ever hired, and noted that the position has "never had this kind of visibility."

Conley's primary responsibility is to ensure that anything NASA launches into space like a planet-bound robot, for example doesn't contaminate a foreign world with its microbes. That's in line with a commitment the U.S. made in the 1967 Outer Space Treaty . Conley also helps to prevent any alien microorganisms from reaching Earth.

"It is extremely important that as we explore space that we do it in a careful way," she said. "If you want to find life on other planets, you have to be careful not to find Earth life by accident."

As NASA continues to explore places with the potential for life like Mars or Europa, an icy moon of Jupiter Conley's job has become more significant.

"The biggest challenge of my job are the people who don't see why this is important," she said. "Individuals who want to explore these places have different levels of risk that they accept. But when you're dealing with something that could impact the whole planet, you have to take everyone into consideration. It's very rewarding to ensure that the international guidelines are upheld."

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NASA's 'Planetary Protector' on What Everyone Gets Wrong About Her Job - Fortune

This 9-Year-Old Applied To A Job At NASA To Help Fight Aliens And His Qualifications Are Spot On – BuzzFeed News

"One of the reasons is my sister thinks I'm an alien."

Posted on August 07, 2017, 03:46 GMT

"I may be nine but I think I would be fit for the job," Jack wrote. "One of the reasons is my sister says I am an alien. I have also seen the show Marvel Agents of Shield and hope to see the movie Men in Black.."

Jack also pointed out that he's great at video games and since he's young, he can learn to think like an alien. Clutch.

He signed the letter: "Jack Davis, Guardian of the Galaxy, Fourth Grade."

The job "is about protecting Earth from tiny microbes when we bring back samples from the Moon, asteroids and Mars," James L. Green, director of NASA's planetary science division, explained to the nine-year-old applicant. "It's also about protecting other planets and moons from our germs as we responsibly explore the Solar System."

Green then encouraged Jack to study hard, do well in school, and apply again when he's older, at which point there will perhaps be actual aliens threatening our planet.

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This 9-Year-Old Applied To A Job At NASA To Help Fight Aliens And His Qualifications Are Spot On - BuzzFeed News

NASA-Orange 14s foiled by World Series-bound Brownsville at Zone – Chron.com

Cole Bratten works on his hitting at Pasadena's 3K batting cages two days before the team left for Louisiana and the South Zone Tournament.

Cole Bratten works on his hitting at Pasadena's 3K batting cages two days before the team left for Louisiana and the South Zone Tournament.

NASA-Orange 14s foiled by World Series-bound Brownsville at Zone

YOUNGSVILLE, La. - The NASA-Orange Pony 14-year-old all-stars made a gallant run towards a World Series berth, but the team fell three victories shy of the prize Saturday afternoon.

Once again, a team from the Rio Grande Valley proved too much for the Houston-area squads as Brownsville defeated NASA-Orange twice in the four-day tournament. With three victories in their opening four contests, NASA-Orange earned a berth in the National Bracket championship game Saturday only to absorb a 12-2 defeat.

It was just the day before that NASA-Orange overcame a 5-0 deficit to the same Brownsville team, scoring two runs in the third, four in the second and two in fifth to nab an 8-6 lead. Just six outs away from jumping in the National Bracket driver's seat, Brownsville scored four in the sixth and one in the seventh to collect an 11-8 win.

Brownsville went on to capture the South Zone championship, following a tense 2-1 victory over American Bracket champion Laredo Sunday afternoon. Laredo was forced to the IF game Sunday morning with Crowley, La. Laredo won that match-up 14-1.

NASA-Orange, attempting to become the second NASA-Pony League representative over the last three summers to clinch a World Series berth, was deadlocked with Brownsville 1-1 after one inning in the second meeting, but that's when Brownsville scored three in the home half of the second and six in the third to seal the deal.

Jorge Lozano was the starting and winning pitcher, while Henry Hill suffered the loss, lasting just 2.1 innings in which he gave up nine earned runs on eight hits. He walked one and struck out three.

Luke Olson and Cole Bratten had the only NASA-Orange hits.

NASA-Orange departed the tournament starting gates like gangbusters. They walloped the Gregory-Portland All-Stars 17-0 Wednesday night, before doing the same to Arnaudville, La. 13-3 Thursday night.

In the Gregory-Portland game, NASA-Orange scored six in the second, four in the third and seven in the fourth. Anthony Benavides shattered a NASA Pony League record when he belted a pair of home runs in driving in eight RBIs on a 3-for-3 effort at the plate, scoring three runs. But those would be Benavides' only RBIs of the entire tournament.

Simon Binetti went 3-for-3 with three runs scored and an RBI, while Logan Moore and Christian Whitehead each enjoyed 2-for-2 games. Moore homered, driving in two RBIs and scored twice as did Whitehead. Olson co-led the team in runs scored with three thanks in part to a double he clouted.

Manager Scooter Moore had the green light on in the stolen base department as the guys swiped 10 bases, three by Benavides, two by Olson and two by Binetti.

Carson Wagner was the starting and winning pitcher, while Bratten and Adam Boyes mopped up. The three combined for nine strikeouts. Rob Spencer absorbed the loss.

Against Arnaudville, NASA-Orange was trailing 3-2 when the team scored four runs in the third to go with two in the fifth and four in the sixth.

The team made Arnaudville pay for a whopping 10 errors, possibly a South Zone record. Hill and Anthony Hall each went 2-for-4 with two RBIs. Whitehead, Benavides, Jacob Martinez, Logan Moore, Hill and Olson combined to score the 12 runs. The team found nine hit off two Arnaudville pitchers and four of them were doubles. Whitehead, Benavides, Hill and Olson tallied the two-baggers.

On the mound, Hall, Hill, Boyes, Bratten and Benavides combined for 16 strikeouts and just five free passes.

In the gut-wrenching first defeat to Brownsville, the four, five and six-hole hitters for NASA-Orange went 5-for-11 with six RBIs and four runs scored. Moore went 2-for-4 with four RBIs, while Hill and Olson drove in one.

Pitching-wise, Benavides, Olson, Wagner and Martinez combined for 11 strikeouts and eight earned runs.

The defense didn't help the pitching, suffering its worst game of the tournament in committing five errors.

Of Brownsville's 11 runs, 10 were scored by the first five batters. Leadoff hitter Darren Ramirez scored three times and three-hole hitter Javier Hinojosa did the same.

Hard to imagine that two neighborly Pony baseball programs would meet on a ballfield almost 200 miles away but that's what happened Saturday morning. NASA-Orange stayed alive by eliminating Deer Park. Deer Park, riding a three-game winning streak after losing on opening night to Brownsville 10-0, came out on the short end to a 5-2 score.

NASA-Orange avenged a Coast Region defeat to this same Deer Park squad last month by scoring two in the third and three in the fifth, erasing a 1-0 deficit.

Six stolen bases and seven Deer Park errors paved the way for the revengeful win. Olson drove in two RBIs and Moore one. A pair of Rudy Fuentes solo homers provided Deer Park's only runs. Davis, in relief of Wagner, was the winning pitcher. Caleb Cox took the defeat, surrendering all five runs but just two were earned.

All-in-all, it was a very good effort by the two Coast Region representatives in the North Bracket. Only three of the eight teams finished with winning records and two of the three were NASA-Orange (3-2) and Deer Park (3-2). The other being World Series-bound Brownsville.

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NASA-Orange 14s foiled by World Series-bound Brownsville at Zone - Chron.com

The Five Principles Of Modern Marketing – AdExchanger

Managing the Data" is a column about customer and audience data strategy written by longtime AdExchanger contributor Chris O'Hara.

Every marketer and media company these days is trying to unlock the secret to personalization. Everyone wants to be the next Amazon, anticipating customer wants and desires and delivering real-time customization.

Actually, everyone might need to be an Amazon going forward; Harris Interactive and others tell us that getting customer experience wrong means up to 80% of customers will leave your brand and try another and it takes seven times more money to reacquire that customer than it did initially.

How important is personalization? In a recent study, 75% marketers of marketers said that theres no such thing as too much personalization for different audiences, and 94% know that delivering personalized content is important to reaching their audiences.

People want and expect personalization and convenience today, and brands and publishers that cannot deliver it will suffer similar fates. However, beyond advanced technology, what do you need to believe to make this transformation happen? What are the core principles a company needs to adhere to, in order to have a shot at transforming themselves into customer-centric enterprises?

Here are five:

Put People First

Its a rusty old saw but, like any clich, its fundamentally true. For years, we have taken a very channel-specific view of engagement, thinking in terms of mobile, display, social and video. But those are channels, apps and browsers. Browsers dont buy anything; people do.

A people-centric viewpoint is critical to being a modern marketer. True people-based marketing needs to extend beyond advertising and start to include things like sales, service and ecommerce interactions every touchpoint people have with brands.

People customers and consumers must reside at the center of everything, and the systems of engagement we use to touch them must be tertiary. This makes the challenges of identity resolution the new basis of competition going forward.

Collect Everything, Measure Everything

A true commitment to personalized marketing means that you have to understand people. For many years, we have assigned outside importance to small scraps of digital exhaust such as clicks, views and likes as signals of brand engagement and intent. Mostly, theyve lived in isolation, never informing a holistic view of people and their wants and desires.

Now we can collect more of this data and do so in real time. Modern enterprises need to become more obsessive about valuing data. Every scrap of data becomes a small stitch in a rich tapestry that forms a view of the customer.

We laughed at the data is the new oil hyperbole a few years back simply because nobody had a way to store and extract real value from the sea of digital ephemera. Today is vastly different because we have both the technology and processes to ingest signals at scale and use artificial intelligence to refine them into gold. Businesses that let valuable data fall to the floor without measuring them might already be dead, but they just dont know it yet.

Be A Retailer

A lot of brands arent as lucky as popular hotel booking sites. To book a room, you need to sign up with your email. Once you become a user, the company collects data on where you like to go, how often you travel, how much you pay for a room and even what kind of mattress you prefer. Any brand would kill for that kind of one-to-one relationship with a customer.

Global CPG brands touch billions of lives every day, yet often have to pay other companies to learn how their marketing spend affected sales efforts. Brands must start to own customer relationships and create one-to-one experiences with buyers. We are seeing the first step with things like Dash buttons and voice ordering, though still through a partner, but we will see this extend even further as brands change their entire business models to start to own the retail relationship with people. The key pivot point will come when brands actually value people data as an asset on their balance sheets.

See The World Dynamically

The ubiquity of data has led to an explosion of microsegmentation. I know marketers and publishers that can define a potential customer to 20 individual attributes. But people can go from a Long Island soccer mom on Monday to an EDM music lover on Friday night. Todays segmentation is very much static and very ineffective for a dynamic world where things change all the time.

To get the right message, right place, right time dynamic right, we need to understand things like location, weather, time of day and context and make those dynamic signals part of how we segment audiences. To be successful, marketers and media companies must commit to thinking of customers as the dynamic and vibrant people they are and enable the ability to collect and activate real-time data into their segmentation models.

Think Like A Technologist

Finally, to create the change described above requires a commitment to understanding technology. You cant do people data without truly understanding data management technology. You cant measure everything without technology that can parse every signal. To be a retailer, you have to give customers a reason to buy directly from you. Thinking about customers dynamically requires real-time systems of collection and activation.

But technology and the people to run it are expensive investments, often taking months and years to show ROI, and the technology changes at the velocity of Moores Law. Its a big commitment to change from diaper manufacturer to marketing technologist, but we are starting to understand that it is the change required to survive an era where people are in control.

Some say that it wasnt streaming media technology that killed Blockbuster, but the fact that people hated their onerous late fees. It was probably both of those things. Tomorrows Blockbusters will be the companies that cannot apply these principles of modern, personalized marketing or do not want to make the large investments to do so.

Follow Chris O'Hara (@chrisohara) and AdExchanger (@adexchanger) on Twitter.

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The business of bottled air – Deutsche Welle

According to the Max Planck Institute for Chemistry, every year more than a million people die in China as a result of air pollution There are other consequences, too: failed harvests, cancelled flights, driving bans. In desperation over the smog in Beijing and Shanghai, inhabitants of the cities have even started importing oxygen in bottles, for 20 dollars apiece. One liter of oxygen is enough for up to 150 inhalations, according toCanadian manufacturers.

Read more: Turning city smog into stunning jewlery

Moses Lam, co-founder of the company Vitality Air, based in Edmonton, Canada, is astonished at his success. In an interview with the television broadcaster CBC he admitted that the whole thing actually started out as a joke. However, when his initial production line of 100 bottles sold out in just four days, he turned it into a professional business.

Clear skies above Canada's Banff National Park

Bestselling mountain air

Vitality Air now has subsidiaries not only in China but also in India, Korea and Vietnam. Every two weeks, 20 employees collect several hundred thousand liters of air in Canada's Rocky Mountains. "Air from the Banff National Park, the first of its kind in Canada, is a bestseller," Moses Lam explains. Production is highly complex, though, as only 20 percent of air is pure oxygen, so it has to be compressed and purified. The precious commodity has a limited shelf-life, too. "The bottles should be used within one or two years," the air salesman recommends.

The Sydney-based company Green & Clean has been filling bottles with Australian air since November 2015 from the Blue Mountains, for example, or the Gold Coast, along the Great Barrier Reef. With a minimum order of 4,000 bottles the Australians have secured a turnover of hundreds of thousands of dollars. Their principal customers come from all over Asia. The company is eyeing Germany as a potential market for the future, a spokesman says, because efforts by car manufacturers, cities and local councils clearly aren't having an effect. He points to the diesel summit as evidence.

The Linde Group sells bottled oxygen

Air as a souvenir

Containers of air may also grace the shelves of some buyers, or their friends as holiday souvenirs. Until now, in the Black Forest, cuckoo clocks have been the souvenir of choice. Elke Ott is offering an alternative to the tradition: She sells Black Forest air. Not bottled, but canned. Entrepreneur Stefan Butz from Bad Kreuznach, on the other hand, prefers clear glass bottles, which he fills with air from the Saarland saltworks.

The Smog Free Tower looks quite futuristic but its purpose is quite grounded: Provide clean air.

Inside the tower is a highly-efficient air filter that consumes very little energy but catches even ultrafine particles. As a result, the air around the tower is up to 75% cleaner than in the city that surrounds it.

Obviously, one tower alone cannot clean the air in the entire city. The idea is more to inspire and provide a space where people can gather, think and breathe freely, even in some of the most polluted cities in the world - in this case, Beijing.

Since Roosegaarde believes in a future where waste does not exist, he had to find some use for the fine particles of pollution that the Smog Free Tower filters out of the air.

Roosegaarde's team decided to take the fine particles and compress them for 30 minutes, before encasing them in acrylic. The result is a stunning cube that gets turned into jewelry like this "Smog Free Ring."

The man behind the project, Dutch designer Daan Roosegaarde wants nothing less than a human right to clean air.

Author: Harald Franzen

Something similar was tried during the soccer world cup in 2006. Back then you could buy "Original Air of Berlin". The joke even preoccupied the Brussels bureaucracy, with the EU warning that more than 30 percent of the tins it analyzed contained high levels of particulate. It didn't stop them going on sale, though.

Along with air as a joke item, there's also bottled air as a political action aimed at improving environmental protection. This was the motivation of Chinese millionaire and philanthropist Chen Guangbiao when he sold bottled air from Chinese rural areas on the streets in 2012.

When the air grows thin

Researchers are already investigating alternatives in case levels of oxygen in the air should drop below the amount we need to breathe.

Naked mole rats can survive a long time in their underground burrows with very little oxygen

They're looking at the idea of limiting oxygen consumption, based on findings by Berlin's Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC). Scientists have discovered that naked mole-rats in their underground burrows can survive for a very long time in suffocating air. In tests, they survived for five hours by absorbing fructose from roots. They would also lower their pulses from 200 to just 50 beats per minute. The scientists are trying to discover whether this could potentially serve as a model for humans. And they've assured us that they have no links to the automobile industry.

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Gaining a Deeper Understanding of the Relationship Between DNA and Cell Function – TrendinTech

Have you ever wondered how different cells in the human body do different jobs when every cell contains the entire 6.5 foot, 20,000 gene strand of DNA? A recent study from researchers at the Weatherall Institute of Molecular Medicine, the details of which are published in the journal Nature Cell Biology, have uncovered a key to understanding this question which has puzzled scientists for some time.

A strand of DNA is not full of genes alone and little is understood about the function of the parts in-between. Some parts are known to be enhancers, which activate or deactivate the relevant genes required by the cells but we still dont know how the enhancers know which ones these are.

Inside our cells, DNA is compactly folded in a specific and organized way, allowing the enhancers access to the part of DNA needed for cell function. This organization is clustered in sections called domains, where each domain is responsible for a specific function. Previous research has singled out the protein responsible for this organization as CTCF. The new study focuses on CTCF and its role in the domain which governs a-globin genes, those that regulate the production of hemoglobin.

When functioning correctly, CTCF defined and organized the domains of the DNA in a red blood cell correctly so that the enhancers had appropriate access to the a-globin parts as needed. However, when parts of DNA were removed so that CTCF function was limited, researchers found that the domain boundaries became less pronounced and the gene enhancers activated more than the a-globin genes needed for proper red blood cell function.

This research not only deepens our understanding of the function of DNA in our cell function but also illuminates possible reasons for the malfunction of genes in a number of diseases. This new understanding of the role of CTCF offers a new area of exploration for possible treatments.

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Connecticut doctor works to repair central nervous system injuries – Torrington Register Citizen

NEW HAVEN >> There is now no way to regenerate severed nerves in the central nervous system, but Dr. Stephen M. Strittmatter is confident hes found a way to repair them.

Hes even founded a company, ReNetX Bio Inc., to shepherd his new therapy through the maze of regulations, clinical trials and manufacturing processes, ultimately hoping to cure patients with devastating injuries.

We have this amazing, complex neural network that manages all our functions, stemming from the brain and spinal cord, said Strittmatter, professor of neurology and neuroscience in the Yale School of Medicine.

When a nerve fiber, or axon, in the central nervous system is damaged, such as in a paralyzing spinal cord injury, it doesnt grow back. Even though the nerve cell is still healthy in the adult brain or spinal cord, it cant grow and therefore function doesnt come back, he said.

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(The central nervous system, which manages all our functions, is separate from the peripheral nervous system, which performs other tasks, such as carrying stimuli from our senses, and which can regenerate.)

The axon, which starts at the cell body, or soma, can extend up to a meter in length, Strittmatter said. If the cell were the size of a baseball, the extension, the nerve fiber, would be the width of a pencil and be a quarter of a mile long, he said.

Strittmatter said he has investigated why nerve fibers cant grow in adults, and that led us to the idea that there are inhibitors that are present in the adult brain and spinal cord. They stop the axons from growing back to where theyre supposed to be.

In fact, there are three such inhibitors, called Nogo, MAG and OMgp, which exist in the myelin that coats the nerve fibers. They stick to the axon and tell it not to grow, Strittmatter said.

He and the researchers in his lab studied ways to stop the inhibitors from attaching to the axon. So we developed this protein, which we call Nogo Trap Its sort of like a double negative; it blocks the inhibitors [and] those new connections allow function to be recovered, he said.

So far, the therapy looks promising. Weve done experiments here that have shown that that works after rats and mice have spinal cord injuries, he said.

Now, ReNetX Bio, a new name for a company founded in 2010 as Axerion Therapeutics, faces the long process of turning an experimental therapy into a marketable drug, which they hope also will be effective for stroke and glaucoma.

Thats what the company is about, bringing it out of the lab and into the clinic, Strittmatter said.

The next step is getting Food and Drug Administration approval of Nogo Trap, also known as Axer-204, as an investigative new drug, which allows phase one clinical trials. That initial phase is only concerned with the drugs safety. The second and third phases test whether or not the drug is effective.

Erika R. Smith, named CEO of ReNetX in July, said there is a long list of other tasks to be addressed, including toxicology testing, scaling up manufacture of the drug and lots of paperwork. A lot of boxes get checked to make sure its OK to try in a clinical setting, she said.

Both Smith and Strittmatter said there are advantages to forming their own company.

I guess I feel like being involved I can help make sure that the right clinical trials are done, Strittmatter said.

Smith added, Theres a lot of challenges in early research that a lot of pharma companies arent willing to take the risk themselves. A lot of times companies wont come in really early.

Along the way, theres all kinds of roadblocks, things we cant expect, Strittmatter said. Drugs might get degraded faster in one species than another or there could be secondary complications like infections.

Were very excited that the experiments that have happened in the lab have gone very well, he said. However, there is a risk. Experimental animal studies can look great but maybe only 20 percent of the time can that be turned into a drug that can be used in people, he said.

But Smith noted the substantial funding that has come into the company to this point were estimating $15 million that has gotten the program to where it is. Much of that support has come from the National Institutes of Health, she said.

The company has a staff of five and is seeking to hire a chief medical officer, Smith said.

Yale University holds intellectual property rights and is a part owner of ReNetX. The company has licensed those patents from Yale so they can go on to do sales and clinical development, Strittmatter said. Yale would receive royalties if it were eventually sold as a drug.

The end goal that it gets to people and it makes a difference in their lives, Strittmatter said.

Smith said, The big picture of this is its a whole new paradigm change for any kind of injury in the central nervous system.

Call Ed Stannard at 203-680-9382.

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New Research Shows the Power of Radiomics to Improve Precision Medicine – Lab Manager Magazine

TAMPA, Fla. Precision medicine has become the leading innovation of cancer treatment. Patients are routinely treated with drugs that are designed to target specific tumors and molecules. Despite the progress that has been made in targeted cancer therapies, the path has been slow and scientists have a long road ahead. In a collaborative project, researchers at theMoffitt Cancer CenterandDana-Farber Cancer Instituteinvestigated the emerging field of radiomics which has the potential to improve precision medicine by non-invasively assessing the molecular and clinical characteristics of lung tumors.Their workwas published in the July 21 issue ofeLIFE, a novel, emerging journal in biomedicine founded by National Academy members and Nobel Prize winners.

Radiomics offers scientists and clinicians a novel way to analyze individual tumors for their biology, guide cancer treatment, and predict response to therapy. Virtually every cancer patient has their tumor imaged though computed tomography (CT), magnetic resonance (MRI), and/or positron emission tomography (PET) as standard-of-care. The images allow physicians to determine the stage and location of a tumor and guide treatment decisions. But with recent advances in computer generated data and models, these images are now being used in the field of radiomics to extract high-dimensional data that can be used to guide precision medicine. By using radiomics, scientists are able to objectively quantitate different features of tumors, such as intensity, shape, size, and texture. These data can then be used in combination with genetic and clinical data to predict active biological pathways, clinical outcomes, and potential effective therapies.

The core belief of radiomics is that images arent pictures, theyre data. We have to treat them as data. Right now, we extract about 1300 different quantitative features from any volume of interest, saidRobert Gillies, PhD, chair of MoffittsDepartment of Cancer Imaging and Metabolism.

This collaboration analyzed CT image features from 262 North American patients and 89 European patients with non-small cell lung cancer (NSCLC). They identified associations between the image features and molecular markers, biological pathways, and clinical outcomes. For example, they determined that certain sets of image features could predict the overall survival of NSCLC patients, while other image features could predict the stage of the tumor or the presence of biological and genetic markers that drive tumor growth. The researchers also demonstrated the clinical importance of radiomics by showing that it is possible to increase prognostic power by combining radiomic data with genetic information and clinical data.

We already knew that radiomic algorithms have strong clinical importance; however, the biological basis for these observations remained unknown. This study now answers this key question for the first time by defining and independently validating the driving biological pathways of radiomic phenotypes saidHugo Aerts, PhD, director of theComputational Imaging and Bioinformatics Laboratoryand associate professor of Radiation Oncology atHarvard Medical School.

Radiomics has several advantages over other commonly used techniques that guide precision medicine. Currently, biological markers are routinely analyzed with tissue biopsies that are invasive, collected only at the beginning of care, and may not accurately reflect the biology of the entire tumor. In contrast, imaging techniques are noninvasive and can provide information about the entire tumor throughout the entire course of treatment and response. Additionally, the majority of cancer patients routinely have images taken for diagnostic purposes already, making radiomics a cost-effective approach.

This study advances the molecular knowledge of radiomic characterization of tumors, information currently not used clinically. This may provide opportunities to improve decision-support in all patients as imaging is routinely used in clinical practice as standard of care, said Gillies.

The study was supported partly by funds from the Tissue Core Facility at Moffitt Cancer Center.

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Grappling with graduate student mental health and suicide – The Biological SCENE

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Credit: Will Ludwig/C&EN/Shutterstock

In brief

Last year, Scripps Research Institute California graduate student Anna Owensby killed herself. Graduate school is hard at the best of times, and it can become overwhelming when students are faced with situations such as having a dispute with an adviser or not passing a milestone such as a qualifying exam. One recent study found that 7.3% of graduate students had suicidal thoughts. But there are practices that advisers, departments, and schools can put in place to support their students mental health.

In the spring of 2016, Scripps Research Institute California graduate student Anna Owensby texted a friend: I have this feeling right now that there isnt really a place for me ... People like me arent supposed to get a Ph.D., we are addicts or homeless or in jail.

Owensby, 26, was a fourth-year graduate student. In her first years at Scripps, she was briefly hospitalized to evaluate her mental health, and she changed lab groups. Her new adviser, Scripps molecular medicine professor Dennis W. Wolan, had assisted in finding her a therapy group that seemed to be helping her. The group was not in Owensbys insurance network, but Scripps was paying for the sessions. She passed her Ph.D. candidacy exam at the end of 2015, at which time her committee members indicated that she was progressing appropriately and that they had no nonacademic concerns about her.

Then, in the space of just a few weeks in spring 2016, Owensby was banned from Wolans lab and told not to contact him or her lab mates. She was encouraged to resign from Scripps and informed that Wolan would not give her a job recommendation.

On April 14, 2016, Owensby died by suicide.

There is no one situation or event that makes a person suicidal, experts in suicide risk and prevention emphasize. We always want to come up with one cause, but it doesnt work that way, says Jill Harkavy-Friedman, vice president of research at the American Foundation for Suicide Prevention. People end their lives when a number of conditions and factors come together to make someone feel overwhelmed and unable to cope.

Nonetheless, there are concrete steps that academic advisers, departments, and schools can take to better support their graduate students mental health and reduce the risk of losing people like Owensby.

In 2015, the rate of death by suicide for people ages 20 to 34 in the U.S. was between 15 and 16 people per 100,000, according to the Centers for Disease Control & Prevention. Suicide is one of the five most common causes of death for people ages 15 to 44 years.

Long-term factors that increase the risk that someone might attempt suicide include a psychiatric diagnosis, substance use disorder, childhood trauma, and family history of suicide.

Few studies have investigated mental health problems and suicide in Ph.D. students specifically. One survey of 3,659 students in Belgium suggests that 32% of Ph.D. students are at risk of having or developing a psychiatric disorder such as depression (Res. Policy 2017, DOI: 10.1016/j.respol.2017.02.008). A separate survey of 301 graduate students at Emory University determined that more than 34% likely had moderate to severe depression, while 7.3% reported suicidal thoughts, and 2.3% reported having plans for suicide (Acad. Psychiatry 2014, DOI: 10.1007/s40596-014-0041-y). The rates of mental health issues in this population are elevated pretty significantly above the general population, says Nathan L. Vanderford, assistant dean for academic development in the University of Kentucky College of Medicine.

In addition to the long-term factors that increase suicide risk, short-term issues such as life transitions and stress also play a role, experts say. Not unlike starting college, the transition to graduate school can involve significant life upheavalbut without the large number of support staff and peers that undergraduates encounter when moving to campus.

Graduate students instead might move to a new location to live in an apartment alone or with a rarely seen roommate and then interact mostly with a relatively small set of classmates and lab mates in one or two buildings. As time goes on, other events can disrupt a students world: An adviser loses a grant, doesnt get tenure, or chooses to move, or a student fails to pass a milestone such as an oral exam. Meanwhile, family and friends might not understand the unique experience of graduate school.

And the stakes are high. Students are putting so much effort and energy into pursuing the degree that every single step can carry a lot of weight. Certainly theres fear of failure or perception of failure, says Christa Labouliere, a clinical psychology professor and administrator for a suicide prevention program at New York State Psychiatric Institute, which is part of Columbia University Medical Center.

A year after Anna Owensby died, her mother, Victoria Owensby, sobs when she tries to talk about her. She was so funny, her heart was so kind, and she was beautiful and brilliant, Victoria says.

Anna Owensby was valedictorian of her high school class and a talented cellist who enjoyed playing music composed by Johann Sebastian Bach. After high school, she initially attended Cleveland Institute of Music. Students at the institute take nonmusic electives at nearby Case Western Reserve University. After a general chemistry class, Owensby reconsidered her career pathshe didnt think she could make money playing the cello, her mother saysand Owensby wound up switching to a chemistry major at Case.

32%

Percentage of Ph.D. students who are at risk of having or developing a psychiatric disorder such as depression, according to a 2017 study. Source: Res. Policy 2017, DOI: 10.1016/j.respol.2017.02.008

2.3%

Percentage of surveyed graduate students who reported having plans to attempt suicide, according to a 2014 study. Source: Acad. Psychiatry 2014, DOI: 10.1007/s40596-014-0041-y

15 to 16

People ages 2034 per 100,000 who died by suicide in the U.S. in 2015. Source: Centers for Disease Control & Prevention

25

People who attempt suicide for every person who dies by suicide. Source: American Foundation for Suicide Prevention

As an undergraduate, Owensby stood out for her enthusiasm and work ethic, says Case chemistry professor Gregory Tochtrop, who taught Owensby organic chemistry before recruiting her to do research in his lab. She was incredibly smart, Tochtrop says. After discussing a research idea, she would track down and read all the same papers a more seasoned scientist would look up. She had the mind-set of Im going to learn something about this so that I can contribute to it, he says.

But Owensby had difficulties as well. Growing up in Greenville, S.C., she was a tough child to parent, often losing emotional control when faced with even minor setbacks, her family says. One of Owensbys aunts, Amy Forton, is a mental health counselor and says Owensby exhibited severe anxiety. She wasnt depressed, though, Forton believes. She was happy and interested in things in life.

Nevertheless, Owensbys difficulty regulating her emotions was significant enough that her mother sought psychological help for her daughter. The therapists just said she was really, really smart and overly perfectionist and sensitive, her mother says. They never said anything about any mental illness, ever.

There were mental health issues in Owensbys family. Her father had alcoholism and died of liver disease while she was in college. Tochtrop believes that the challenges of growing up with her fathers alcoholism and then losing him led Owensby to look for father figures. Owensby tried to push for a more personal connection in an otherwise professional relationship with him, Tochtrop says. Early in college, Owensby would turn to Tochtrop to talk for hours about her life history and problems. It wasnt anything inappropriate, but I think she was looking for things she didnt have, Tochtrop says.

When Owensby was a junior, Tochtropat the time an assistant professor who had a wife in law school, a baby, and an approaching tenure decisionfelt he had to draw a line. He told Owensby that he couldnt help her with personal matters, but he was happy to support her career. Owensby seemed to take the message well, and after the conversation we still had a really good professional relationship, he says.

Owensby used Case counseling services, Tochtrop says, but he doesnt know further details. Once, he noticed that she had been cutting herself. Despite her personal challenges, Owensby graduated from Case having earned several university awards, including one for best thesis in undergraduate chemistry research.

Owensby started at Scripps in 2012. Details of her time there are based on materials provided by and interviews with her family and Tochtrop, who stayed in close touch after she left Case. Scripps refused C&ENs request to interview institute personnel about Owensby and the schools programs to support students mental health. In a statement, Vice President for Communications and Development Cara Miller said, All universities are faced with the challenge of wanting to provide the utmost support for members of their community who may be in need of assistance, while also maintaining their privacy and adhering to legal requirements. Owensbys mother has filed a complaint with Scrippss accrediting commission because although the institute has given her Owensbys educational records, it has withheld disciplinary records.

Anna Owensby (center) with her mother, Victoria Owensby, and her brother, Adam Owensby.

Credit: Courtesy of Anna Owensbys family

During her first years at graduate school, Owensby diagnosed herself with borderline personality disorder (BPD). In January 2015, she began a form of cognitive behavioral therapy with the support of her adviser, Wolan, and Scripps. The director of the therapy center that Owensby used, Milton Z. Brown of the Dialectical Behavior Therapy Center of San Diego, did not respond to voice mail messages left by C&EN.

The National Institute of Mental Health describes BPD as a serious mental disorder marked by a pattern of ongoing instability in moods, behavior, self-image, and functioning. People with BPD often exhibit impulsive actions and have unstable relationships. They go through episodes of anger, depression, and anxiety that can last only a few hours or as long as days. Because Brown did not return C&ENs calls, C&EN was unable to determine whether Owensbys therapists agreed with her self-diagnosis.

An unfortunate consequence of Wolans support in the face of Owensbys mental health challenges may have been that Owensby again sought personal fulfillment in a professional relationship. Looking back, I am just so incredibly grateful for the times you gave me when I felt valued and wanted, as they were the happiest moments of my life, she wrote to Wolan in a letter she last edited a few days before she died. I slowly came to love you like the family I had always wanted.

On Sunday, March 13, 2016, Owensby seemed to be doing well at Scripps. Wolan had texted Owensby, You are working harder than you likely ever have in your life. Andmore importantlyholding it together. Youve come an incredibly long way. Very proud of you! according to a document Owensby later prepared for attorneys.

Then Owensbys life quickly derailed. According to Owensbys notes, on Wednesday, March 16, Wolan called her into his office to ask if shed gone through the drawers of a lab mate with whom Owensby had had a contentious relationship. (Six months earlier, Owensby had suspected the lab mate of sabotaging her research materials.)

On Thursday, March 17, Owensby was unexpectedly escorted from her lab to meet with James R. Williamson, then dean of graduate studies at Scripps and now executive vice president for research and academic affairs. According to Owensbys notes about the meeting, Williamson told her that Wolan had requested her removal because she was disruptive and had gone through other lab members personal property. Williamson told Owensby not to return to the lab and had her identification badge and keys confiscated. Then she was escorted to her car.

On Friday, March 18, Scripps director of graduate studies, Dawn Eastmond, contacted Owensby to ask about laboratory materials needed to continue experiments. Eastmond also told her not to contact Wolan or any of her lab mates.

Owensby considered hiring an attorney to challenge Scrippss actions but decided she couldnt afford one. At a meeting on Thursday, March 31, 2016, with Williamson and Eastmond, Owensby learned more details of why shed been shut out of Scripps. In addition to the accusation about going through lab mates property, Wolan had discovered that in 2014 Owensby and another lab member had accessed Wolans computer and gone through his web browser history.

In her notes for possible attorneys, Owensby maintained that the other, more senior, lab member was the instigator and she was a bystander. She felt an enormous amount of social pressure to laugh along with the other lab member when they were searching Wolans computer because of a fear of harassment from that person, Owensby wrote. Owensby also alleged that the other lab member had a history of inappropriate behavior, including using lab resources without Wolans knowledge to generate materials for a project the lab member planned to undertake elsewhere.

In texts to a friend after the meeting, Owensby wrote about the next steps Scripps planned to take: They say they have conflicting testimony. They will basically feel it out and [Eastmond], [Williamson], and a [Scripps] lawyer will make a decision. [Eastmond] told me she envisions that either I resign or get terminated.

Over the next couple of weeks, Owensby continued to text the same friend, expressing concern about how long Scripps would continue to pay her and whether she would have enough money for rent. She also said that she was applying for jobs, but even McDonalds wants to talk to your previous supervisor, she wrote. I dont know what Im gonna do.

Owensby also met with Brown, one of her therapists. He later told her family that he tried to help her problem solve throughout the entire course of events. Around Tuesday, April 5, Owensby called Eastmond from Browns office to ask about getting a recommendation from Wolan. Owensby texted a friend that Eastmond said Wolan didnt want anything to do with her.

On Wednesday, April 13, 2016, Eastmond called Owensby to suggest that she resign from Scripps. Owensbys texts to a friend say that Scripps would pay her until the end of April. After Owensby died, Forton, her aunt, spoke with Wolan and Eastmond. According to Fortons notes about the meeting, Eastmond says she informed Owensby that Scripps would continue to pay for her health insurance through June.

On Wednesday and Thursday, April 13 and 14, Owensby tried several times to contact Wolan. She also spoke for the last time with Tochtrop, who says he thinks about the conversation nearly every day. She was worried about her career and what she could do, Tochtrop recalls. I really tried to emphasize how incredibly smart and talented she was. I said that I would do anything I could to make sure she had a safe landing and found a position.

Meanwhile, Owensby also spoke with and texted friends. Can you watch Curie for a little bit tonight, she texted one on Wednesday, referring to her beloved dog. I need to have some time alone.

The friend wasnt able to take Curie that evening, and Owensby repeated the request on Thursday. Wolan and Eastmond each contacted Owensbys therapist that day, concerned about Owensbys behavior. No one contacted Owensbys family.

Thursday evening, Owensby killed herself.

We deeply mourn Annas sudden passing, Williamson said in a Scripps obituary. She was extremely bright and truly passionate about science. Our sympathies go out to her family, close friends and colleagues. We are all struggling to come to terms with what has happened, and we are doing our best to come together to generate a support network for those most affected.

Cultivating mental health

Given Owensbys mental health history, she was at high risk for attempting suicide after Scripps personnel barred her from her lab and encouraged her to resign. Ideally, Scripps personnel and Owensbys therapists would have been aware of her risk for suicide.

Generally, however, predicting suicide is hard, says Sidra J. Goldman-Mellor, who studies suicide risk as a professor of public health at the University of California, Merced. For any given person in a program, its going to be really difficult to know if theyre at high risk for suicide, because a lot of people hide it. What that means is that its important to make sure there is support for all students.

That support should go beyond sending an annual e-mail with a list of resources, suicide risk and prevention experts say. Additional steps to take might include holding events such as stress-management workshops or sponsoring thesis-writing support groups. You want to make it a culture in the department to acknowledge that graduate school is hard and there are things you can do to help cope with it, Columbias Labouliere says. Maybe then people wont get to the point of feeling trapped.

Some chemistry departments are making efforts to reduce stress where they can, foster more open discussions about mental health, and encourage students to talk with each other.

When Philippe Buhlmann, a chemistry professor at the University of Minnesota, became his departments director of graduate studies, he made it his mission in that role to promote mental health. He started by working with UMNs mental health services to develop a survey of chemistry graduate students to figure out their primary stressors. The most intense ones turned out to be the interrelated needs to publish and to find a job upon graduation. We cant eliminate those, Buhlmann says. We want 100% of our students to get a job.

But Buhlmann and colleagues did identify some measures that the department could take to reduce students stress. For example, the department reconsidered annual student progress reports and self-evaluations. Without guidance, some students are harder on themselves than they should be. They come up with their own scale that by all objective assessment is twisted, Buhlmann says. Now, after the students self-evaluate, their advisers must also weigh in to concur or correct the students assessment, clarifying expectations and improving communication in the process.

The department also now requires that fourth-year students meet with their thesis committee members to talk about research progress and career aspirations. Students were worried that this would be just another hoop to jump through, Buhlmann says. But Im getting very positive feedback. It gives students other perspectives and pushes them to think more realistically about how to reach their postgraduation goals.

Buhlmann also formed a student-run group called the Community of Chemistry Graduate Students (CCGS) that has a $3,000 budget to plan events promoting physical, mental, and social health. Activities so far have included hosting weekly runs and biweekly social hours, creating videos about depression, and holding panel discussions on topics such as stress reduction or how to write a rsum. If we have too many things that are too strongly focused on mental health, then we dont get good turnout, says third-year chemistry graduate student and CCGS chair Evan Anderson. If we mix things up, then we get better attendance overall. A recent picnic had 150 attendees, which included more than half of the graduate students in the department.

Similar efforts are afoot in the department of chemistry and chemical biology at Harvard University. That department tried to implement changes after graduate student Jason Altom died by suicide in 1988at the time, the departments fourth suicide death in eight years. Some of those efforts, such as a biweekly catered dinner, didnt stick.

A switch to multiprofessor doctoral committees did lastbut different faculty approached committee responsibilities differently, such as how often they met with students. Starting with this falls incoming class, however, there will be some standardization: To alleviate the stress of having to choose committee members and corral them for meetings, those tasks will fall to the departments director of graduate studies. Starting in their second year, students will have annual meetings with their committee in April, and the department has developed some basic guidelines about what those meetings should cover.

Additionally, the department has formed a Community Committee composed of faculty, staff, students, and postdocs who are charged with promoting department cohesiveness and communication. It has sponsored a Thanksgiving dinner for people remaining in the Cambridge, Mass., area during the holiday; sessions on mindfulness; chair massages; and Fruitful Wednesdays during nutritional awareness month, when students can gather and chat while picking up free fruit to eat. The committee does not yet have a budget because it is new, but money is not a constraint; we will do things as they make sense, says Elizabeth A. Lennox, director of laboratories and codirector of graduate studies in the department.

Meanwhile, the departments Graduate Student & Postdoc Council has a $19,000 annual budget for social gatherings and what Lennox calls fun but academically constructive events. For example, the committee organized faculty to give talks about their experiences applying for academic jobs, running a lab, and rising from junior to senior faculty.

The increased efforts toward supporting mental health and building community were a priority set by professor Charles M. Lieber when he became department chair in 2015. A culture survey had shown that morale was down across the board in the department, something that Lieber attributes to a lack of transparency. Lieber emphasizes that expectations remain high for Harvard students, postdocs, and faculty. But promoting openness helps alleviate some of the issues created when people stay in their labs and offices and dont talk with each other, he adds.

Although general programs to promote mental, physical, and social health are important, it is also critical for people to know how to respond when someone is in acute distress. Owensby was already connected with therapists when her life upended. But most people who are depressed or suicidal dont make it to a counseling center, says Julie Cerel, a psychologist and professor at the University of Kentucky College of Social Work and president of the American Association of Suicidology. She says training people who are naturally part of students environmentgatekeepers such as lab managers, faculty, and other departmental staffcan help identify those in need of intervention. In departments in which people arent used to discussing mental health, training can also provide scripts they can use to begin conversations.

Anna Owensby with her dog, Curie.

Credit: Courtesy of Anna Owensbys family

Such training, however, doesnt mean that faculty or other department members become therapists. There are professional limitations and personal boundaries that should not be crossed, UMNs Buhlmann emphasizes. He was a pilot trainee in a now-expanding effort at UMN to train mental health advocates within each academic unit. The advocates are taught a 4R approach: recognize when people are in trouble, assume the role of listener, respond by giving them options, and direct them to appropriate resources.

Additionally, Buhlmann brought in UMN mental health services staff to train graduate student teaching assistants to recognize the signs of stress and mental health problems in chemistry undergraduates and how to direct them to appropriate help. These skills could also transfer to interactions with peers.

At Harvard, Lennox arranged for the schools mental health services to conduct mental health awareness training this spring for the lab group administrators within her department. These administrators might be physically present in labs and see members in person more often than faculty do, Lennox says.

Lennox is also working with mental health services to develop a mental health curriculum to add to the departments routine training for students and postdocs. Shed like to include topics such as signs of mental distress, suicide risk awareness, and campus resources.

As part of an overall campus approach, schools should also ensure that on-campus clinicians are trained in suicide prevention response and how to implement measures that can quickly ensure someones safety, Labouliere says. Those interventions include determining how to restrict access to whatever method someone has chosen to use to attempt suicide. One of the reasons someone is suicidal is an impaired ability to solve problems. Consequently, once someone has a suicide plan, he or she is unlikely to change it when faced with a barrier. Another intervention is safety planning, which involves talking through and writing down what actions to take when suicidal thoughts take over.

Suicidal thinking does not last forever, Labouliere notes. In the moment, people might find their pain unbearable, but if they can get through that crisis, then they likely can engage in therapy, consider their options, and work to address whatever factors led to the situation. She adds that its important to tell people in crisis that effective, research-supported treatments are available. A lot of folks that feel suicidal are so hopeless and feel that their problems are so intractable that the message that there are treatments can be very powerful, she says.

If someone does die by suicide, its important for the department and school to step up actions to pay attention to their community. Cerels research suggests that after someone dies by suicide, as many as 30 people might have their lives majorly disrupted. Its not just a handful of close family members whose lives are changed, she says. Also, I think that suicides can really hit science departments hard because theyre not used to talking about feelings, she says.

Since Buhlmann has started bringing up the topic of mental health in his department, theres been tremendously positive feedback from other faculty, he says. Anyone whos been a chemistry professor long enough knows students in their group or department who have severely struggled, he adds. There are so many good people out there who want to help but dont know how. When you start to talk about it, everyone engages.

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Grappling with graduate student mental health and suicide - The Biological SCENE

Medicine’s gender revolution: how women stopped being treated as ‘small men’ – The Conversation AU

For a long time, medication dosages were adjusted for patient size and women were simply small men.

Men and women respond differently to diseases and treatments for biological, social and psychological reasons. This is the first article in our series on Gender Medicine, where experts explore these differences and the importance of approaching treatment and diagnosis through a gender lens.

Until the turn of this century, there was little sense in Western medicine that gender mattered. Outside the niche of female reproductive medicine, the male body was the universal model for anatomy studies.

Clinical trials mainly involved males and the results became the evidence base for the diagnosis and treatment of both genders. Medication dosages were typically adjusted for patient size and women were simply small men.

Medical academia has also been male-centred, with teachers, professors and researchers being mostly male. Twenty-five years ago, most college boards representing medical specialities around the world were almost exclusively male.

Read more: Female doctors in Australia are hitting glass ceilings why?

But in the last 20 years, mainstream medical research has begun to seriously explore gender differences and bias in academic and clinical medicine. This explicit recognition of gender along with factors such as ethnicity and socioeconomic status helped determine how healthy all peoples lives are likely to be.

And so, the discipline of gender medicine (also called sex-specific medicine) was born. Gender medicine centres opened in the early 2000s, textbooks followed and gender modules were introduced into some medical training and curricula.

In 2008, the World Health Organisation issued guidelines on teaching gender competence. This is the capacity for health professionals to identify where gender-based differences are significant, and how to ensure more equitable outcomes.

Gendered medicine is not only about women. It is about identifying differences in clinical care and ensuring the best health care is provided for all. It is also about ensuring equity of health care access, and about gender equity in the composition and roles in the profession.

Gender is not the same as sex, which is about biological and physical male-female differences. Gender relates to the social and cultural behaviours we attach to the biological aspects of sex; it is not binary and exists on a spectrum.

In medicine, gender impacts how, when and why a person accesses medical care, and the outcomes of that access. For instance, women seeing their doctor for chronic pain often dont feel adequately listened to or supported.

Read more: Women with endometriosis need support, not judgement

In the area of heart health, women are less likely to seek help for a heart attack as their symptoms make it harder to identify. Studies have also found they dont receive potentially beneficial treatments for heart disease in the same way men do, and have lower survival rates.

In mental health, depression is more common in women and suicide rates are higher in men. The nature of diseases such as heart disease, osteoporosis and lung cancer are different between women and men too, as are their outcomes.

Less well known is that two-thirds of the blind people in the world are women, even when the data is adjusted for the fact women live longer. And as an example of sociological differences that need recognising, women who present with an eye socket fracture, a ruptured eyeball or eye bruise are at risk of dying, not from the injury, but from a further assault by a perpetrator of family violence.

Clinical trials are the bedrock of medical research and evidence building. Until relatively recently, they were mainly conducted with males for a number of reasons, including availability to participate and concerns about the impact on womens reproductive health, or the impact of menstrual cycles on the trials.

Restricting difference also makes trials cheaper by reducing the required sample size (even though it leads to inaccuracies for various important subgroups).

Women were excluded because they are different, but the results were applied to them because they are nearly the same. And when women and men are included in trials, the results are usually not published separated by sex, so the findings may be inaccurate for all participants.

Even in pre-clinical research using animals, female animals have been excluded to make management and costs simpler, and reduce measurement variation.

As a result, large scale clinical trials have yielded findings based on particular population groups. For example, a 1988 study into the use of aspirin to lower the risk of heart attack was based on a six-year trial of 22,000 men.

But change is afoot in trial design. Australias largest medical research grant body, the National Health & Medical Research Council, for example, has introduced guidelines that require applicants to address gender equity among research participants.

We need data from clinical trials and population data that is sorted by gender, so knowledge bases can be gradually improved. Generalisations about gender can be both useful and problematic, so careful analysis is needed.

We must account for gender in all medical training, and clinical practice. This should apply to not only disciplines that relate to sex hormones such as gynaecology, but also for example orthopaedics and ophthalmology.

We need the profession itself to take the lead in encompassing gender diversity in our community. Following the lead of non-medical groups such as the Australian Institute of Company Directors, the medical profession needs to introduce targets for diverse representation on all professional decision-making bodies.

Sarah, an Australian medical student in her final year, told me the biological perspective is taught well, but the psychological and social not so much.

There are broader social and cultural factors that might affect the way a male patient presents versus a female.

Medical training on diversity also needs to include people who are transgender or who identify as non-gender conforming. As Sarah said:

We talk about inequalities in terms of males and females, but gender diversity isnt mentioned at all. I shudder to think of the barriers and obstacles you might face in training if you were transgender or non-gender conforming. I havent heard anyone raise that.

Read todays other piece in the Gender Medicine series - Man flu is real, but women get more autoimmune diseases and allergies

Continued here:

Medicine's gender revolution: how women stopped being treated as 'small men' - The Conversation AU

From 8615 applicants, Penn State College of Medicine welcomes incoming class of 152 – LancasterOnline

Penn State College of Medicine recently held its 50th annual white coat ceremony to welcoming its incoming class of 152 future doctors.

The medical school is located just outside Lancaster County and is affiliated with Penn State Hershey Milton S. Hershey Medical Center, which is located on the same campus.

The class included 55 Pennsylvania residents, including several from Cumberland, Dauphin and Lancaster counties.

The white coats marked their entrance to the medical profession as student physicians.

The medical school said the students were selected from a pool of 8,615 applicants. The 82 women and 70 men had 71 different undergraduate majors, have been to more than 50 countries and speak more than 25 languages.

It also noted that more than 40 percent of the incoming students identify as part of an ethnic minority -- and on a lighter note, that three play the ukulele.

Originally posted here:

From 8615 applicants, Penn State College of Medicine welcomes incoming class of 152 - LancasterOnline

Dr. David Katz, Preventive Medicine: Ending a decade of diet lies – New Haven Register

Ancel Keys, arguably the most influential nutrition scientist of the past half-century, died in 2004 at the age of 100. Keys invented the K ration, named for him, that provided our deployed military with portable and complete nutrition. He was among the first, if not the first, to hypothesize that heart disease was not an inevitable consequence of aging but likely related to diet and lifestyle.

Obvious as that now seems, someone had to be the first to consider it and that someone was Ancel Keys. He developed and directed the Seven Countries Study, a colossal undertaking that tested the above hypothesis, concluding that variation in dietary sources of saturated fat notably meat and dairy contributed importantly to cardiovascular risk.

Throughout most of his life, Keys was celebrated as a public health hero. He graced the cover of TIME Magazine as such in 1961. In the years leading up to his death, however, and in the decade since, much of the public commentary about Keys, his lifes work, his seminal Seven Countries Study, and his integrity has been derogatory. There are five apparent reasons for this.

The first is perhaps best described as Newtonian: for every action, an equal and opposite reaction. Maybe we simply cant resist the inclination, whenever someone settles securely on a pedestal weve placed under them, to shift our efforts to knocking them down.

The second might best be described as Aesopian, as in the Aesops Fable that says: we are all judged by the company we keep. The latter years of Keys life, and those since his death, were concurrent with misguided forays into low-fat dietary boondoggles, and somebody had to be blamed for Snackwells. In many quarters, that somebody wound up being Ancel Keys, for having pointed out the harms of dietary fat albeit only certain dietary fat in the first place.

The third reason is that everyone seems to love a good conspiracy theory. So, there were careers to launch and books to sell, as there are today, by telling us all that everything authorities had advised was wrong, that the real truth was being concealed, distorted or suppressed. As one of the worlds preeminent epidemiologists, Keys was among such authorities, and thus an obvious target of conspiracy theory, revisionist history and alternative facts.

The fourth reason was the advent of the internet.

Once upon a time, you needed actually to know something to broadcast expertise, because an editorial filter stood between you and the public at large. There were ways around this, of course, such as the reliance on celebrity as an alternative to content knowledge as a basis for selling books, lotions, potions or programs. But even so, the means of disseminating messages favored those with some claim to genuine merit.

Now, anyone with internet access can broadcast opinion, masquerading as expert opinion, into the echo chambers of cyberspace, where those who own the same opinion already will amplify it. So, for instance, those totally devoted to eating or selling meat, butter and cheese are also apt to eat up, and regurgitate, any allegations against those pointing out the related liabilities.

The fifth is the most obvious: along with not wearing plaid, dead men dont fight back very effectively, either. Keys has mostly been turned into a scapegoat since dying. By way of reminder, he lived to 100 and applied what he thought he knew about diet and lifestyle to himself. That alone would make him a candidate for both celebrity and expert status today. One imagines the book: Diet of the Century.

The popular allegations against Keys are: (1) he cherry picked countries to enroll in his study to align with the beliefs he already held; (2) he fudged or selectively presented data to make a case aligned with the beliefs he favored; (3) he either failed to study sugar or misrepresented findings about it; and (4) he advocated for a now generally discredited low-fat dietary pattern.

The True Health Initiative, a 501c3 nonprofit organization I founded to identify and disseminate the fundamental truths about lifestyle and the health of people and planet alike, based on the weight of evidence and the global consensus of experts, commissioned a White Paper to determine the veracity of these claims. The paper, with its extensive and fully transparent bibliography of primary source material, was just released, and is accessible to all. The basic conclusion is that all popular disparagements of Keys and his research are demonstrably false.

Lies, repeated often enough, can smother the truth. After a decade of lies about Ancel Keys and the Seven Countries Study, its time for the truth to break free, and strike back clad in plaid or otherwise.

Dr. David L. Katz;www.davidkatzmd.com; founder, True Health Initiative

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Dr. David Katz, Preventive Medicine: Ending a decade of diet lies - New Haven Register

Almond Aesthetic Medicine staff complete program – Herald and News

Certified physician assistant Cathy Noble, along with Jen Schuster and Leah Boyer with Almond Aesthetic Medicine in Klamath Falls have all recently completed the Continuing Education Learning Program and passed the written examination for the Laser Training Institutes course in Aesthetic Laser Procedures, according to a news release. This course focuses not only on laser hair removal, but also light based non-ablative skin rejuvenation and the treatment of benign pigmented lesions and red vascular lesions. They also received updates on their academic training in skin and hair biology, laser and intense pulsed light use and energy concepts, tissue optics and laser effects and laser hazards and safety.

With the completion of the Aesthetic Laser Procedures course, Schuster has also applied for and received her advanced aesthetician certification from the state of Oregon.

Almond Aesthetic Medicine offers laser and intense pulsed light use procedures, dermal fillers and injectables, multi-derm abrasion and SkinPen collagen treatments, medical-grade chemical peels and skincare products. They are also partners with Allergans Brilliant Distinctions patient rewards program.

Almond Aesthetic Medicine is at 2613 Almond St. and is open 9 a.m. to 5 p.m. Wednesday through Friday. For more information, call 541-887-8229 or visit facebook.com/almondaestheticmedicine.

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Almond Aesthetic Medicine staff complete program - Herald and News