‘Grey’s Anatomy’ Spinoff Spoilers: What Will New ABC Series Be About? – International Business Times

ABC is gearing up to release aspinoff for Shonda Rhimes hit TV series, Greys Anatomy.

According to TV Line, the new show is expected to premiere on ABC sometime midseason. The spinoff to Ellen Pompeos hit serieswill follow the lives of a group of heroic firefighters who risk their lives in the line of duty. For the past 13 seasons, Greys Anatomy has featured a slew of firefighters who arrive at the hospital either to seek treatment or to send patients to receive the best care they deserve. According to Variety, Rhimes will also act as executive producer and will be working alongside Betsy Beers and showrunner Stacy McKee.

Read:Greys Anatomy alum Isaiah Washington exitsThe 100

Meanwhile, the upcoming spinoff is rumored to air on ABC on Thursday nights right after Greys Anatomyairs at 8 p.m. EDT. Greys Anatomy will also return to the network for Season 14 in September. The hit medical drama has been renewed by the network for Season 15.

In the finale episode of the latest season ofGreys Anatomy, Dr. Stephanie Edwards (Jerrika Hinton) risked her own life to help save a young girl while some parts of the hospital went down in flames. Even though she got out alive, Dr. Edwards expressed her desire to leave her practice later during her conversationwith Dr. Webber (James Pickens Jr.).

Edwards storyline didnt come as a shock to fans because Hintons departure from Greys Anatomy has already been reported several months back. The actress will be moving on to a different project thats also being helmed by Rhimes.

Elsewhere in the episode, Owen Hunt (Kevin McKidd) found out that his sister, Megan, is very much alive. Meredith Grey (Pompeo) broke the news to Nathan Riggs (Martin Henderson). The latter was in a relationship with Megan andblamed himself for months and months on end, thinking that Megan is already dead. Meredith and Nathans relationship is just starting, but things can end for the two characters even before they begin with Megans arrival in Season 14.

Meredith Grey (Ellen Pompeo) will soon cross paths with a group of firefighters in the upcoming spinoff for Greys Anatomy. Photo: ABC

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'Grey's Anatomy' Spinoff Spoilers: What Will New ABC Series Be About? - International Business Times

Balance Your Mind and Body with a Natural Approach to Anti-Aging – FOX31 Denver

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Some say 40 is the new 30. That may be true, but for a lot of women, their 40's can present many annoying challenges, otherwise knows as peri-menopause. Doctor Carrie Louise Daenell is an internationally recognized anti-aging expert who speaks all over the world on the topic of natural medicine. She joined us this morning to share how to naturally balance the 40's mind and body through supplementation and bio-identical hormones.

Dr. Daenell uses targeted nutritional supplements to rebuild metabolism and bio identical hormones to restore balance. Insurance doesn't cover her work, but she has a great offer for our Colorado's Best viewers: The first 25 callers will receive over $200 off the initial consultation, making it only $199. This deal is only available today, so call now at (303)399-8050. You can learn more about heart health, bone health and digestion on DrDaenell.com.

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Curbing Calories Slows Aging – Anti Aging News

Posted on May 23, 2017, 6 a.m. in Longevity Aging Diet

Research analysis finds that cutting calories works at a physiological level to slow biological aging.

The study was lead by Daniel Belsky, Ph.D. an assistant professor of medicine at the Duke University School of Medicine. Previous research has shown that calorie restriction hinders the aging process in mice, worms, and flies. The question is to what extent such restriction has on the biological aging process in human beings. Biological aging is best defined as the slow but progressive deterioration of the human body's systems over time. If the biological aging rate can be slowed through intervention, it might be possible to delay or prevent the onset of numerous age-related disabilities and diseases.

About the Analysis

Belsky and her team of researchers studied data available to the public from a trial known as CALERIE. The National Institute on Aging conducted this study involving 220 individuals. They were randomized for a calorie restriction of 25 percent or allowed to maintain their current dietary intake. The calorie restriction group was comprised of 145 people. Their calories were reduced by 12 percent across the two-year study. The other group, in which calories were not restricted, was comprised of 75 individuals. The research team studied data from both groups at the beginning of the study. Follow-ups took place at the one-year point as well as the two-year anniversary.

The Results

One method calculated the biological age for participants according to their chronological age as well as the biomarkers that gauge the function of the liver, kidneys, immune system, metabolic system, and cardiovascular system. Hemoglobin levels, systolic blood pressure, and cholesterol were also accounted for. At the beginning of the study, both groups had similar biological ages as determined by the measure described above. The average biological age of the participants was 37 while the average chronological age was 38.

Once the one-year follow-up point was reached, those in the restricted calorie group had an average biological age increase of 0.11 years. The participants who continued their normal dietary intake experienced an average biological age increase of 0.71 years at the one-year follow-up. The difference between these groups was statistically meaningful, showing that restricting calories really did deter the biological aging rate.

The research team also performed another analysis that quantified biological aging as the level of physiological deviation from a benchmark defined by young and healthy individuals from a distinct data set. At the beginning of the trial, the maintenance and calorie-restricted groups deviated the same level on average from the benchmark point. However, at the one-year and two-year follow-up points, the average deviation among the maintenance group stayed the same. The group in which calories were restricted gradually became more similar to the healthy and young benchmark reference point.

The findings were consistent with the mitigated aging researchers found in the group with restricted calories when the biological age calculation method was applied. Interventions to offset or control aging are at the center of medical research.

Study Importance

This was the first study to gauge whether the restriction of calories could mitigate measured biological aging in human beingsin a randomized setting. This study applied the measures of physiologic age described above and demonstrated their value as well as the apparent value provided by restricting calories to slow the aging process. The results suggest a template to develop and study therapies meant to copy the effects of restricting calories to ward off chronic diseases.

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Dr. Manjula Raguthu is recognized by Continental Who’s Who – MENAFN.COM

(MENAFN Editorial) --> BROWNSVILLE, Texas, May 16, 2017 /PRNewswire/ -- Dr. Manjula Raguthu is recognized by Continental Who's Who as a Top Doctor of 2017. Dr. Raguthu is a Physician at Medwin Family Medicine & Rehabilitation.

According to their website, Medwin Family Medicine & Rehabilitation, established in 2002, is a healthcare facility that "serves patients of all ages and is aimed at delivering high quality and comprehensive health care services at two locations." The physicians at Medwin Family Medicine & Rehabilitation are dedicated to providing patients with utmost care with convenient locations and flexible office hours.

Recognized as one of the Best Family Physicians in America by the Consumer's Research Council of America for 2009, 2006 and 2004, Dr. Raguthu holds 32nd rank in Family Practice Boards in America. She has received distinctions in the fields of Microbiology and Opthalmology, and an Exemplary Leadership Award in her field in 2001. Additionally, she was awarded the Distinguishedumanitarian Award, and was named the Professional of the Year in 2015 and 2016 by Elite American Physician, as well as many other honors throughout the course of her career.

Heavily educated in her line of work, Dr. Raguthu earned her Postgraduate Diploma in Obstetrics and Gynecology in addition to a Bachelor of Medicine and Bachelor of Surgery from Guntur Medical College in 1990, and completed her residency at St. Vincent's Medical Center in New York. In 2008, she was Re-Certified in Family Practice and holds an Advanced Trauma Life Support Certification, Medical Office Management Certification and is a Certified Medical Coder and Certified Compliance Officer.

For more information, please visit http://www.medwinfamily.com

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Bacteria can paint with light, thanks to genetic engineering – Science Magazine

By Ryan CrossMay. 22, 2017 , 11:00 AM

Nope. Youre not looking at a Bob Ross still life. This faintly colored image was painted by bacteria (Escherichia coli) that produce colored pigments in response to light. Scientists designed the bacteria by adding 18 new genes to their genetic circuitry, including thousands of DNA bases that code for light sensor proteins that respond to red, green, or blue light. Exposure to the light makes the bacteria turn on a gene that kicks off a chemical reaction, producing a corresponding red, green, or blue pigment. Other genes act like circuit breakers to keep the system from overloading. The paint-by-light images were produced by mixing the bacteria into a gel on a petri dish and placing them in an incubator exposed to projector or laser light. Using this setup, scientists recreated the Massachusetts Institute of Technology logo, Super Mario, a tiled pattern of lizards, and a pile of fruit (above), they report today in Nature Chemical Biology. Although the art is unlikely to be displayed alongside works by Van Gogh or Monet, the genetically engineered bacteria could have other practical applications. The scientists say their light-responsive circuit could help control the flux of metabolic pathways in vats of microbes used to produce pharmaceuticals or industrial chemicals, by turning on and off in response to red, green, and blue lighta veritable bacterial disco.

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Western Pennsylvania beekeepers abuzz on genetic engineering – Tribune-Review

Updated 5 hours ago

A theory to solve the nation's ever-worsening bee decline through genetic engineering has Western Pennsylvania beekeepers split about whether it will work.

We have to start working with bees that are locally adapted to the areas we keep them, explained Dwight Wells, 77, a founding member of the Heartland Honeybee Breeders Cooperative and president of the West Central Ohio Beekeepers Association who was a guest speaker at a weekend seminar in Beaver County. Beekeepers have got to understand their bees like farmers understand their crops and cows and pigs. Farmers are careful on the genetics they have in herds and fields big-time. They're looking for proper genetics.

Beekeepers have to start thinking along the same line and start calling themselves bee farmers.

Wells has worked with Purdue University geneticists since 2013 to improve the genetics of honeybees by mating them with queen bees that have adapted to chew off the legs of Varroa mites, also known as Purdue ankle biters. The parasites have long been blamed for honeybee loss because they transmit deadly diseases.

Wells said there are many theories that attempt to explain the mysterious colony collapse disorder, which surfaced in 2006. But he is convinced the main problem is linked to the Varroa mite and malnourished bees a problem he believes is solvable by combining the genetics of mite-resistant bees with Southern, commercial bees that are not fully adapted to surviving harsh winters.

Al Fine, owner of Fine Family Apiary, is not sure the project will work in the long run.

Fine, who keeps about 130 colonies at farms and backyards throughout Allegheny, Washington and Westmoreland counties, lost about 60 percent of his honey bees this winter.

Beekeepers can't afford not to treat for mites because we have to treat them to keep business going, Fine said.

He makes money by selling bees and honey and by renting out colonies to farmers. Business suffers when bees die off in winter, so Fine said he has a vested interest in keeping his bees alive.

To replenish his stock, he buys packages from large-scale commercial beekeepers in Georgia.

You like your strawberries I like blueberries and squash is really good, and people like zucchini, Fine said. Bees are always going to be moved.

According to the Atlanta-based American Beekeeping Federation, bees contribute nearly $20 billion to the country's agriculture industry by pollinating everything from apples to cranberries, melons and broccoli. Crops such as blueberries and cherries are almost entirely dependent on bee pollination. Almonds are entirely dependent on their pollination.

An estimated two-thirds of the country's 2.7 million bee colonies are transported to different farms across the nation throughout the year, ABF reports.

To keep his bees alive, Fine usually sprays them with an organic pesticide twice a year. The spray, he said, burns Varroa mites with naturally occurring acids. This year, however, he plans on using three or four treatments.

But Wells' genetic improving program is not necessarily targeting large beekeeping operations, which typically move bees long distances, said John Yakim, president of the Beaver Valley Area Beekeepers Association. He thinks the program would work if hobbyists who own five to 10 hives, like himself, introduced Purdue ankle biters to the region.

Yakim met Wells at a Pennsylvania State Beekeepers Association seminar in November 2014. Since then, he said he has been learning about the practice and wants others to be exposed to it as well.

BVABA hosted its Queen Raising Seminar on Friday and Saturday in Baden. Participants received unmated queen bees that Yakim and Wells hope mate with local drones.

This is designed for small-scale hobbyist and sideliners, Yakim said of the genetic improving program.

But that doesn't mean he thinks the program couldn't potentially work for large-scale beekeeping operations.

I don't see why not, even for producers with 10,000 colonies. The underlying science isn't going to change, he said.

The science lies in combining the genes of climate survivability and Varroa mite resistance, Wells said.

The problem with bees bought by beekeepers is that most of them are adapted to live in warmer climates, such as Georgia and Florida, where most commercial stock is produced, Wells said.

Beekeepers have been relying on chemicals since the 1980s to treat for mites. But mites develop resistance. And now they're running out of chemicals, Wells said. The smart ones are understanding they got to start developing their own stocks in order to kill mite spells. They're in trouble, and they realize it.

Dillon Carr is a Tribune-Review staff writer. Reach him at 724-850-1298, dcarr@tribweb.com or via Twitter @dillonswriting.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, inspects his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

The queen bee, marked with a yellow dot, can be seen inside an observation hut Al Fine, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017. Fine

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, lights a ball of cardboard for his smoker, before he inspects his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017. The Smoke is believed to mask the bees alarm pheromones, which blocks the bees ability to raise the alarm of an intruder.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, removes the cover of a beehive, before inspecting the hive after recently introducing a new queen, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, removes the cover of a beehive, before inspecting the hive after recently introducing a new queen, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017. The Smoke is believed to mask the bees alarm pheromones, which blocks the bees ability to raise the alarm of an intruder.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, searches for a newly introduced queen, while inspecting his bee hives at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, inspects his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

The dark bodied queen bee, crawls around a frame, as Al Fine, owner of Fine Family Apiary, inspects his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

Honey bees, owned by Al Fine, owner of Fine Family Apiary, stand at the uncovered entrance to the bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017. Fine

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, inspects his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, takes a break while inspecting his bee hives, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017. Fine

Dan Speicher | Tribune-Review

Al Fine, owner of Fine Family Apiary, poses for a portrait in his bee keeper suit, at Triple B Farms in Monongehala, on Wednesday, May 17, 2017.

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Western Wayne students participate in PJAS competition – News … – Scranton Times-Tribune

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Western Wayne High School and Middle School students competed at the state meeting of the Pennsylvania Junior Academy of Science held May 14-16 at Penn State University, Main Campus. Representing the high school: Mallory Jablon received a first award for her research in behavioral science and was chosen as a Pennsylvania Science Talent Search award recipient. Kirstin Metschulat received a first award for her research in behavioral science. Darlene Black received a second award for her research in ecology. Caitlin Falloon served as a technician for the presentations. Representing the Middle School: Jamie Bryan received a first award for her research in behavioral science. Caydence Faatz received a second award for her research in zoology. From left: Jamie, Caydence, Kirstin, Caitlin, Darlene and Mallory.

Western Wayne High School and Middle School students competed at the state meeting of the Pennsylvania Junior Academy of Science held May 14-16 at Penn State University, Main Campus. Representing the high school: Mallory Jablon received a first award for her research in behavioral science and was chosen as a Pennsylvania Science Talent Search award recipient. Kirstin Metschulat received a first award for her research in behavioral science. Darlene Black received a second award for her research in ecology. Caitlin Falloon served as a technician for the presentations. Representing the middle school: Jamie Bryan received a first award for her research in behavioral science. Caydence Faatz received a second award for her research in zoology. From left: Jamie, Caydence, Kirstin, Caitlin, Darlene and Mallory.

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Resveratrol May Benefit Diabetics' Cardiovascular Health – Anti Aging News

Researchers have discovered an antioxidant that may potentially help protect cardiovascular functions in patients with diabetes. Details on the study were presented at the 2017 Arteriosclerosis, Thrombosis, and Vascular Biology and Peripheral Vascular Disease Scientific Sessions in Minnesota. The American Heart Association sponsored the event. Ji-Yao Ella Zhang Ph.D. from the Whitaker Cardiovascular Institute at the Boston University in Massachusetts led the team. Dr. Naomi M. Hamburg, doctor of Cardiology and Internal Medicine, was the studys senior author.

Resveratrol

The compound Resveratrol is an antioxidant found in grape products such as juice and wine, certain berries, peanuts, and cocoa. The compound belongs to a class of chemicals known as polyphenols, which are antioxidants that come from plants. Previous research has suggested that polyphenols may help improve cardiovascular functions and reduce damaging inflammation.

Stiff arteries are a byproduct of the aging process. Those affected by diabetes experience premature arterial aging. Hardened arteries increase risks of experiencing a heart attack, stroke, and high blood pressure.

Previous studies using animals as test subjects has shown that Resveratrol helps reduce hardening of the aorta. The aorta pumps oxygenated blood from the heart to the rest of the body. The studies show that Resveratrol activates the SIRT1 gene, which is associated with slower aging processes. The team at Boston University wanted to explore if the compound had the same effect on humans.

Clinical Study

Fifty-seven participants were chosen for the study. The average age of participants was 56 years. All patients had type II diabetes and had a body-mass index (BMI) that indicated obesity.

Patients were given 100 mg doses of Resveratrol daily for a two-week period. The dosage was then increased to 300 mg for another two weeks. After a two-week washout period, the participants were given a placebo for a total of 4 weeks.

Most of the participants saw no changes in arterial stiffness. However, a subgroup of 23 patients with particularly high arterial stiffness saw a 9% decrease with the 300 mg dose and a 4.8% decrease with the 100 mg dose. The placebo treatments seemed to increase overall arterial stiffness.

Study Conclusions

While the exact mechanism is not known, researchers conclude that Resveratrol treatment reverses abnormalities in blood vessels caused by aging, obesity, and diabetes. The compound appears to improve structural issues in the aorta but does not relax blood vessels. This means that Resveratrol treatment benefits diabetes patients more than those without this condition.

Further study is necessary to confirm these findings.

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Major finding in human anatomy has implications for many brain diseases, including Alzheimer's – The Denver Post

By David Kohn, The Washington Post

Kari Alitalo had studied lymphatic vessels for more than two decades. So he knew that this network, which carries immune cells throughout the body and removes waste and toxins, didnt extend into the brain: This had been accepted wisdom for more than 300 years. Nobody questioned that it stopped at the brain, says Alitalo, a scientist at the University of Helsinki in Finland.

Three years ago, Alitalo wanted to develop a more precise map of the lymphatic system. To do this, he used genetically modified mice whose lymphatic vessels glowed when illuminated by a particular wavelength of light. (The mice had been given a gene from a species of glowing jellyfish.)

When viewing the modified mice under the light, Aleksanteri Aspelund, a medical student in Alitalos laboratory, saw something unexpected: The heads of the mice glowed. At first, he suspected that there was something wrong with the animals, the lighting or the measuring equipment. But when Alitalo and Aspelund repeated the experiment, they got the same result. It seemed that the lymphatic vessels extended to the brain after all.

This was surprising, to say the least: In the 21st century, major findings involving basic human anatomy are rare. These days, you dont make discoveries like this, Alitalo says. But every once in a while in science, you stumble on something really unexpected. You open a new door, to a whole new world.

Alitalo is one of several scientists exploring this new world. Working independently, several other researchers, including Maiken Nedergaard of the University of Rochester and Jonathan Kipnis of the University of Virginia School of Medicine, have also shown that lymphatic vessels extend into the brain.

The discovery is much more than a historical footnote. It has major implications for a wide variety of brain diseases, including Alzheimers, multiple sclerosis, stroke and traumatic brain injury.

Researchers have identified two networks: the vessels that lead into and surround the brain, and those within the brain itself. The first is known as the lymphatic system for the brain, while the latter is called the glymphatic system. The g added to lymphatic refers to glia, the kind of neuron that makes up the lymphatic vessels in the brain. The glymphatic vessels carry cerebrospinal fluid and immune cells into the brain and remove cellular trash from it.

Alitalo, Nedergaard, Kipnis and others have found evidence that when the systems malfunction, the brain can become clogged with toxins and suffused with inflammatory immune cells. Over decades, this process may play a key role in Alzheimers disease, Huntingtons disease, Parkinsons disease and other neurodegenerative illnesses, research suggests. This is a revolutionary finding, Nedergaard says. This system plays a huge role in the health of the brain.

Nedergaard describes the glymphatic system as like a dishwasher for the brain. The brain is very active, she says, and so it produces a lot of junk that needs to be cleaned out.

In hindsight, she says, the system should have been noticed long ago. When the skull and head are dissected, the vessels are visible to the naked eye. But no one bothered to really look: Usually the brain is seen only as a bunch of nerve cells. We have come to think of the brain as a computer. And its not. Its a living organ.

Nedergaard and Helene Benveniste, a scientist at Yale University, have found evidence linking problems in the lymphatic and glymphatic systems to Alzheimers. In a study on mice, they showed that glymphatic dysfunction contributes to the buildup in the brain of amyloid beta, a protein that plays a key role in the disease.

Last year, Jeff Iliff, a neuroscientist at Oregon Health & Science University, and several colleagues examined postmortem tissue from 79 human brains. They focused on aquaporin-4, a key protein in glymphatic vessels. In the brains of people with Alzheimers, this protein was jumbled; in those without the disease, the protein was well organized. This suggests that glymphatic breakdowns may play a role in the disease, Iliff says.

The vessels have also been implicated in autoimmune disease. Researchers knew that the immune system has limited access to the brain. But at the same time, the immune system kept tabs on the brains status; no one knew exactly how. Some researchers theorize that the glymphatic system could be the conduit and that in diseases such as multiple sclerosis where the bodys immune system attacks certain brain cells the communication may go awry.

The system may also play a role in symptoms of traumatic brain injury. Nedergaard has shown that in mice, the injuries can produce lasting damage to the glymphatic vessels, which are quite fragile. Mice are a good model, she says, because their glymphatic systems are very similar to humans. She and Iliff found that even months after being injured, the animals brains were still not clearing waste efficiently, leading to a buildup of toxic compounds, including amyloid beta. Nedergaard returns to the dishwasher analogy. Its like if you only use a third of the water when you turn on the machine, she says. You wont get clean dishes.

Recent research has also found evidence that the glymphatic system may extend into the eye. For decades, scientists have noted that many people with Alzheimers disease also have glaucoma, in which damage to the optic nerve causes vision loss. But they struggled to find a common mechanism; the glymphatic system may be the link.

In January, Belgian and Swiss researchers identified a rich network of glymphatic vessels within the optic nerve. The scientists also found that when these vessels malfunction, they seem to leave behind deposits of amyloid beta as well as other neurotoxins that damage the optic nerve.

And in March, Harvard University researchers reported that glymphatic flow is significantly decreased in the period just before a migraine. The intense pain in these headaches is caused largely by inflamed nerves in the tissue that surrounds the brain. Neuroscientists Rami Burstein and Aaron Schain, the lead authors, theorize that faulty clearance of molecular waste from the brain could trigger inflammation in these pain fibers.

One key to glymphatic performance seems to be sleep. Nedergaard has shown that at least in mice, the system processes twice as much fluid during sleep as it does during wakefulness. She and her colleagues focused on amyloid beta; they found that the lymphatic system removed much more of the protein when the animals were asleep than when they were awake. She suggests that over time, sleep dysfunction may contribute to Alzheimers and perhaps other brain illnesses. You only clean your brain when youre sleeping, she says. This is probably an important reason that we sleep. You need time off from consciousness to do the housekeeping.

Nedergaard and Benveniste have also found that sleep position is crucial. In an upright position someone who is sitting or standing waste is removed much less efficiently. Sleeping on your stomach is also not very effective; sleeping on your back is somewhat better, while lying on your side appears to produce the best results. The reason for these differences remains unclear, but Nedergaard suspects that it is probably related to the mechanical engineering of the lymphatic vessels and valves; she suggests that the healthiest approach may be to move periodically while you sleep.

Sleep is probably not the only way to improve glymphatic flow. For instance, a paper published in January by C
hinese researchers reported that in mice, omega-3 fatty acidsimproved glymphatic functioning.

Benveniste is examining dexmedetomidine, an anesthetic that may have the ability to improve glymphatic flow. And in a small human study, other scientists have found that deep breathing significantly increases the glymphatic transport of cerebrospinal fluid into the brain.

Alitalo is experimenting with growth factors, compounds that can foster regrowth of the vessels in and around the brain. He has used this method to repair lymphatic vessels in pigs and is now testing the approach in the brains of mice that have a version of Alzheimers.

Right now there are no clinical therapies in this area, he says. But give it a little time. This has only just been discovered.

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Major finding in human anatomy has implications for many brain diseases, including Alzheimer's - The Denver Post

Chemistry, in a book and a board game – Chemical & Engineering News

The many meanings of chemistry

Weike Wangs experience as an undergraduate in a chemistry lab at Harvard served as the inspiration for her debut novel, Chemistry, available from publisher Alfred A. Knopf this week. The novel confronts many issues relevant to graduate students, including what it means to love science.

After an incident involving some smashed glassware, the main character takes a stress-related leave of absence from her chemistry lab. She grapples with whether to return to her Ph.D. program while entertaining a marriage proposal from her boyfriend, who has finished his degree and is preparing to take the next step in his career. The decision of whether to be honest with her strict parents about her diversion from the straight and narrow weighs heavily on her as well. She accepts a position tutoring students in math and science while she examines her options and reflects on how she arrived at this point.

Wang herself completed her doctorate in epidemiology at Harvards T.H. Chan School of Public Health in April. While working toward her doctorate, she also completed an MFA in creative writing at Boston University. She originally wrote Chemistry for her creative writing masters thesis. I didnt know I was going to write a novel until it was sort of happening, she tells Newscripts.

Wang says that working on her writing degree during the research phase of her doctorate was helpful because it allowed her to figure out where her passions lie. I actually enjoy writing when its going terribly, she says. But I hated research when it was going terribly. Although a lot of academic scientists are drawn to the creative side of research, Wang says that isnt the case for her; writing is her creative outlet.

But science is a clear inspiration throughout the novel. Wangs love of chemistry and physics is evident in the way she weaves scientific concepts into her writing. Theres a lot of beauty in science, just like theres a lot of beauty in art and music and language, something both the general public and researchers could stand to be reminded of, she says. I wanted to present science in a way that was interesting and stimulating.

Ethnicity features prominently in the novel as well. People who go into science are disproportionately Asian, she says. I wanted to investigate thatif we go into it because we love it, or if we go into it because of other forces. If the latter, Wang wonders, what happens when things dont work out?

Wangs primary purpose in writing the novel was to make people think about why theyre doing what theyre doing, which she says is a question that everybody should ask. She has no plans to pursue a position in epidemiology just yet: I am sort of hoping this writing thing might work out.

Organic chemistry can be daunting. Thats why a team of students at the University of California, Berkeley, has developed React!, a multiplayer board game that helps learners get comfortable building molecules and carrying out reactions using illustrated cards, markers, and dry-erase boards.

React! is meant to be accessible to everyone from high school students to working chemists, and no prior organic chemistry background is needed. The game was chosen as one of three winners of UC Berkeleys Big Ideas start-up competition, and the students are running a Kickstarter campaign to help launch the game.

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Chemistry, in a book and a board game - Chemical & Engineering News

Brandin Cooks’ chemistry with Tom Brady among Pats’ OTA storylines – ESPN (blog)

FOXBOROUGH, Mass. -- The New England Patriots move to the third phase of the voluntary offseason program this week, holding their first organized team activity on Monday. Players can now be at the facility for up to six hours and take part in 7-on-7 and 11-on-11 drills.

While the first OTA open to the media isnt until Thursday, here are a few things of particular interest in the no-pads setting:

Cooks chemistry. The Patriots are loaded at wide receiver with the addition of speedy Brandin Cooks, who joins an already solid depth chart of Julian Edelman, Chris Hogan, Malcolm Mitchell and Danny Amendola. When watching an OTA, it is commonplace to hear quarterback Tom Brady talking to his pass-catchers about how precise he likes routes to be run as the work begins to develop a foundation to take into training camp. Cooks, in particular, will be one to watch.

Gilmore and Butler at corner. After an offseason of uncertainty as to whether Malcolm Butler would be back in New England, the Patriots can now boast that they have arguably one of the NFLs best 1-2 cornerback tandems with Butler and Stephon Gilmore. This will be their first chance to work together in 7-on-7 and 11-on-11 drills -- where coaches often stress the importance of communication -- with reporters also potentially getting a feel for which cornerback the coaching staff currently views as the top option in the slot in a three-corner nickel package.

Any sign of Gronkowski? Tight end Rob Gronkowski is making progress in his return from back surgery that prematurely ended his 2016 season, and this will be a chance for further context on how far along he is. If Gronkowski can get in the ring as part of a WWE show, is it unreasonable to think he could be on the field in a non-contact, no-pads setting?

A new look at running back. While running backs coach Ivan Fears has passionately pointed out that it isnt real football until players are in full pads, this will be a first look at how natural Mike Gillislee and Rex Burkhead look catching the football. They join James White, Dion Lewis and D.J. Foster atop the depth chart in a new-look backfield. The Patriots no longer have a big, power rusher with LeGarrette Blount now in Philadelphia, as Gillislee has a similar physical makeup as Stevan Ridley at 218 pounds.

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Brandin Cooks' chemistry with Tom Brady among Pats' OTA storylines - ESPN (blog)

Predicting which undergrads will succeed in chemistry – Chemistry World (subscription)

Researchers at Washington University in St Louis have examined cognitive differences in university students that may contribute to their high dropout rate from introductory undergraduate chemistry courses. They found that those who can make accurate extrapolation predictions based on concepts presented in class what they dub abstraction learners consistently outperformed so-called exemplar learners who have trouble doing so and instead depend on rote memorisation. These performance differences were even more pronounced for those enrolled in higher level organic chemistry courses.

The Washington University team studied more than 800 students taking chemistry courses over three semesters at a highly competitive US research university, roughly half of whom were classified as having difficulty bridging the gap between a concept and an illustrative example. The researchers used a learning assessment to determine how well these students understood abstract concepts presented during a fictional assignment that required them to learn the functional relation between two new elements associated with a new organism supposedly discovered on Mars.

The researchers found that active learning, at least in the form of a peer-led approach, helped a subset of the exemplar learners perform better. To determine whether these results are replicated in other introductory scientific courses and at other research institutions, the researchers are studying these effects in other science, technology, engineering and mathematics (Stem) classes and at different universities.

Tools to anticipate which students might have difficulty in chemistry and other science subjects are helpful as poor grades in these classes are a major contributor to undergraduates leaving Stem degrees. We know people who are rote learners struggle with science, and if we can identify them early, we can change the curriculum and put in supplemental support, study co-author Regina Frye tells Chemistry World. Since we have shown that their concept-building approach does predict their effective performance, now we are looking at what types of interventions you may use that could help these students.

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Predicting which undergrads will succeed in chemistry - Chemistry World (subscription)

Whitecaps see chance to "make a deep run" as chemistry, consistency grows – MLSsoccer.com

VANCOUVER, B.C. Consistency is the name of the game forVancouver Whitecaps FC right now, and it's no coincidence that its reaping results.

Carl Robinson fielded an unchanged starting lineup for the fifth straight match in Saturday's 2-0 win over Western Conference leaders Sporting Kansas City at BC Place. Vancouver's new-look 4-1-4-1 lineup had brought the 'Caps some success on the road in a tough four-game road stretch. They came back with six points and could have had more, given their four fine performances.

Robinson admitted he toyed with the idea of mixing things up, but went with an if it ain't broke, don't fix it approach, and it paid off.

"I gave it lots of thought," Robinson said. "Sometimes you get it right when you win, or get a result or a performance, and sometimes you dont. So lots of thought has gone into it. I just felt it was right."

The Whitecaps recent chemistry has been noticeable, especially on the defensive side, with two clean sheets in their last three matches. Elsewhere on the pitch, link-up play is improving every game as players understanding grows. With three wins in their last four games, the results speak for themselves.

Defender Sheanon Williams says hes excited by what may lie in store for this group.

"As the weeks go on I have started to feel more comfortable with the players that Im playing with on my side," said theMLS veteran. "This team is a team that day in, day out, comes to work. Even the substitutes that come on, you can see the work that everybody does for each other its something that I havent seen. Its a credit to the team and the guys we have in that locker room.

"I have been in the league eight years and this is definitely the most excited that I have been to be on a team. I think that this team has everything to make a deep run and to be successful in this league. Im excited and I hope everyone else is."

Center backTim Parker agrees.

"In the backline it's great, we're grooving pretty well now," he said. "We're not giving up many chances. In front of us, it's good. We all understand the kind of team we want to be and the kind of players we want and how we want to play the game."

But Robinson doesn't want his team to feel too settled. Injuries and a lack of available bodies are factors in the Whitecaps' lineup stability, and as much as he likes the consistency and chemistry, the coach also wants competition for places.

"I just said to them, when players become healthy, competition will rise," Robinson said. "Challenges for your starting spot will rise. The strong will come out and the weak will have to get their head down and fight again. And thats what pleases me the most. You know, weve been consistent, weve performed, weve got some really good results."

Starting this week, Robinson will have to balance rotation, competition and continuity. The games now come thick and fast for Vancouver, starting with a two-legged Canadian Championship semifinal against the Montreal Impact that opens at BC Place on Tuesday night (10 pm ET | TSN1 in Canada).

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Whitecaps see chance to "make a deep run" as chemistry, consistency grows - MLSsoccer.com

For Theo Epstein, chemistry now matters — a lot – New Haven Register

NEW HAVEN >> Theo Epstein recalled sporting a Red Sox hat when he sat amidst the vast crowd at Yales Class Day ceremonies 22 years ago, even though he had recently finished an internship with the Orioles.

Two days later, after commencement exercises, Epstein boarded a plane for San Diego ostensibly donning a Padres hat, beginning his career in Major League Baseball in that teams front office.

At Yales 2017 Class Day program on Sunday, Epstein was again a man of many hats, swapping his Yale cap for a Cubs hat midway through his address as this years featured speaker. Like the lids atop his head, Epstein, who has led both the Red Sox and Cubs to historic, curse-busting World Series titles, has proven to be amenable to change.

Famously calling for longtime Yale football coach Carm Cozza to step down while the sports editor of the Daily Campus as a Yale junior, Epstein has since confessed to regretting the situation. More famous as one of the poster boys of analytic and sabermetrics that has engulfed baseball over the past 15-20 years, Epstein has similarly changed his tune a bit.

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Thats one of the great ironies of the digital information age, he said shortly after his speech. Now theres so much information out there, so much data and statistics, that its easy to attempt to precisely quantify a players contribution. You can never really quantify a human being. You cant quantify character. That stuff does matter, especially in a group situation, where players really do have impact on one another and leadership matters. The ability to bounce back from adversity matters, lifting each other up in tough moments. Its something that Ive come to appreciate more and more, every year, each of the 26 years Ive worked in baseball.

The gist of Epsteins speech, which included a good-natured request for Yankees fans to head for the exits and his own astonishment that he would ever be invited back as Class Day speaker (If you had ranked all the people, whos most likely to come back, I probably would have been last, he said afterwards), centered around the now-famous story of the Cubs ability to bounce back from adversity last season and win their first World Series in 108 years. Specifically, he pointed to the story of how the team, led by slumping outfielder Jason Heyward, held a meeting in the midst of a brief rain delay during Game 7 that rallied the troops to their ultimate historic victory.

Many sabermetricians of today, some of them disciples of Epstein, often pooh-pooh things like clubhouse chemistry and players with good character, arguing that, ultimately, its all about the numbers. But Epstein has diverged off that path in recent years.

I think theres a wide spectrum of ways people assess talent, he said. I still think datas important, because it can give you some real, empirical truths about a player. Facts are important, objectivity is important. But you have to combine it with an understanding of the player as a human being.

Chemistry is really hard to pinpoint and discern the magic formula, he continued, but if you look for enough high-character players, players who are invested in one another and are willing to connect, that really helps uplift the whole team.

Epstein was in good spirits during his return to Yale, reflecting on the good times he had as an undergrad. He specifically remembered the speech delivered by Baltimore Mayor Kurt Schmoke at Class Day in 1995, which encouraged people to live heroic lives in small, understated ways.

Epsteins memories of his visits to Toads Place were a little more fuzzy.

Really, the best memories are just pre-partying with friends, then heading there and all the hijinks that would ensue on a nightly basis. The best memories, by definition, you cant remember.

Epstein has helped deliver lifelong memories to Red Sox and Cubs fans, and hopes this years Cubs team can make more. The Cubs have been idling around .500 as they try to snap out of a potential post-World Series hangover. Epstein sees some similarities with the 2005 Red Sox, who were coming off their first world title in 86 years the prior October.

I remember in 05, we dealt with a lot of injury problems, he noted. We dealt with some downturns in performance, and we had to scratch and claw our way to 95 wins and get into the postseason. We were kind of spent by the time the postseason rolled around. I hope that this year, we find a way to fight through it and show up in October in a little bit better condition, ready to play another month of baseball.

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For Theo Epstein, chemistry now matters -- a lot - New Haven Register

Why Puma Biotechnology Inc Jumped Higher Today – Motley Fool

Documents from the FDA suggest the agency is open to the possibility of approving neratinib. What happened

Shares ofPuma Biotechnology(NASDAQ:PBYI) are up 44% at 12:12 p.m., having been up as much as 84% today, as investors digest the Food and Drug Administration documentsposted ahead of Wednesday's advisory committee meeting to review the approvability of Puma's breast cancer drug neratinib.

Today's jump wasn't because of surprisingly good data but rather a relative lack of negative opinions of neratinib by the FDA reviewers.

Puma Biotechnology is trying to get neratinib approved as an extended treatment for breast cancer after the patient has received surgery followed by Herceptin and chemotherapy. The clinical trial showed that adding neratinib to that standard of care decreased the reoccurrence of breast cancer compared to placebo after a year of treatment with neratinib. But the drug causes severe diarrhea in many patients, which leads to patients reducing the dose or stopping the drug altogether.

Good efficacy with poor tolerability has led investors to worry about the approvability of the drug. The company'snegotiatingwith the FDA over which patients to include in the analysis didn't help, although that issue appears to be mostlyworked out. Today's review was fairly neutral, with the documents for the advisory committee noting that the efficacy analysis was basically the same using either set of data, "supporting an effect of neratinib" while also pointing out that "the tolerability of neratinib in this patient population is a concern."

Image source: Getty Images.

The lack of a negative review is good news for Puma Biotechnology, but given the fairly neutral stance, the committee of outside experts could have a big influence on the FDA's final decision when they meet on Wednesday. The biggest thing for investors to watch is the committee's opinion of the diarrhea side effect and whether the members think treating with an antidiarrheal prophylaxisis an acceptable way to combat it. The doctors' opinions on neratinib relative to other post-surgery treatments will also be important because a negative opinion relative to the other treatments could foretell poor neratinib sales even if the drug is approved.

Brian Orelli has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Dr. Orelli is a Senior Biotech Specialist. He has written about biotech, pharmaceutical, and medical device companies for The Motley Fool since 2007.

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Why Puma Biotechnology Inc Jumped Higher Today - Motley Fool

Puma Biotechnology: Shares on the prowl – Times of India

BUZZ-Puma Biotechnology: Shares on the prowl:BUZZ-Puma Biotechnology: Shares on the prowl

** Puma Biotechnology shares soar 50.3 pct to $56.80 in heavy Monday morning trading; shares rise as high as $69.35, halted multiple times for volatility

** U.S. Food and Drug Administration posts documents reviewing Puma's neratinib for treating breast cancer ahead of FDA advisory committee meeting on the product on Weds

** Based on sensitivity analyses conducted, results appear to be generally similar to the primary analysis results, supporting an effect of neratinib, FDA staffers say in review documents

** Options market has been pricing in a move about 63 pct, positive or negative, in PBYI shares in reaction to neratinib review, JPMorgan analyst Cory Kasimov said in research note last week

** Short interest in PBYI shares stood at 21.5 pct of shares outstanding as of Apr 27, according to Thomson Reuters data

** Five analysts rate PBYI shares a "buy" or "strong buy", two rate "hold", according to TR data; median price target is $80

** PBYI shares have nearly doubled in 2017, against 9.7 pct rise for Nasdaq Biotechnology index

(This story has not been edited by timesofindia.com and is autogenerated from a syndicated feed we subscribe to.)

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Puma Biotechnology: Shares on the prowl - Times of India

Why Puma Biotechnology, Applied Optoelectronics, and Ferroglobe Jumped Today – Motley Fool

Monday was a good start to the week for stocks, with major benchmarks climbing around half a percent on the day. Most market participants pointed to a lack of bad news over the weekend and anticipation about expected favorable economic data in the coming days as drivers of the generally positive attitude among investors.

But there are still plenty of factors that are preventing stocks overall from mounting stronger gains, including nervousness about geopolitical issues as well as weaker parts of the global economy. Nevertheless, some stocks posted strong gains, and Puma Biotechnology (NASDAQ:PBYI), Applied Optoelectronics (NASDAQ:AAOI), and Ferroglobe (NASDAQ:GSM) were among the best performers on the day. Below, we'll look more closely at these stocks to tell you why they did so well.

Image source: Getty Images.

Shares of Puma Biotechnology soared 39% as investors anticipated that the biotech company will get approval of its neratinib breast cancer drug from the U.S. Food and Drug Administration. An FDA advisory committee is scheduled to meet later this week, and documents supporting that meeting were released today. In those documents, investors found fewer critical views of neratinib than some had expected, and that led those following the stock to conclude that the drug is likely to get a favorable review from the advisory panel. That by itself won't mean certain approval for neratinib, as the final decision from the FDA doesn't necessarily hinge on the advisory panel. Nevertheless, positive signs have investors excited about Puma, and there's potential for further gains if the FDA does indeed follow through with approval later this year.

Applied Optoelectronics stock climbed 12% after the supplier of fiber-optic components got a favorable review from Wall Street analysts. Needham & Co. began its coverage of Applied Optoelectronics stock with a strong buy rating, arguing that the company has a lot of growth potential stemming from moves among enterprise data center users to upgrade their performance and incorporate faster transfer speeds. Needham set an $85-per-share price target on the stock, which still gives investors nearly 20% upside from current levels. If Applied Optoelectronics can turn the new upgrade cycle into accelerating growth, then investors could see even greater gains in the long run.

Finally, shares of Ferroglobe rose 9%. The producer of silicon metal and various related alloys released its first-quarter financial results, which included flat revenue compared to the fourth quarter of 2016 and a minimal net loss for the quarter. Shipment volumes were down from year-ago levels, but a rise in prices for manganese alloys was sufficient to keep total average selling prices relatively steady. Yet CEO Pedro Larrea was optimistic about the company's performance, noting that "significant margin improvement reflects solid demand across end markets and a continued improvement in the overall pricing environment." Even with the gains, Ferroglobe shares have lost half their value in the past two years, but investors are optimistic that the company can earn back some of those losses over time.

Dan Caplinger has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

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Why Puma Biotechnology, Applied Optoelectronics, and Ferroglobe Jumped Today - Motley Fool

Global Biotechnology Congress 2017 – Student Registration: Boston … – Business Wire (press release)

DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of the "Global Biotechnology Congress 2017 - (5th in the Series) Student" conference to their offering.

The 'Global Biotechnology Congress 2017' would provide eminent scientists the opportunity to present their cutting edge researches in the field of biotechnology and its applications in medicine. A number of Nobel Laureates and leading researchers are expected to participate in this important conference.

This unique international conference provides a platform for researchers and decision makers in biotechnology to present their latest findings and learn about all the important developments in biotechnology. Many Nobel Laureates and world's renowned experts will participate in the conference.

The conference will cover the translational nature of biotechnological research, with emphasis on both the basic science as well as its applications in industry and academia. Presentations will include major research advances in biotechnology, business development, strategic alliances, partnering trends, product opportunities, growth business models and strategies, licensing and pharmaceutical biotechnology (e.g. vaccines, CNS, cancer, antibodies), medical biotechnology, industrial biotechnology, bioprocess engineering, protein engineering, plant and environmental technologies, transgenic plant and crops, bioremediation, and microbial diversity research.

Throughout the course of the four day conference, you will have the opportunity to both network and hear leaders from the international academic and corporate biotechnology communities.

Benefits of Attending

- Exchange ideas and network with leading biotechnologists and decision makers.

- Bring together top international biotechnology professionals presenting cutting-edge discoveries, research and opportunities for new biotech business practices and partnerships.

- Participants can gain direct access to a core audience of biotechnology professionals and decision makers, and have increased visibility through branding and networking at the conference.

- Obtain a global roundup of Pharmaceutical research capabilities and opportunities.

- The conference will feature a commercial exhibition and poster sessions.

For more information about this conference visit http://www.researchandmarkets.com/research/3859jd/global

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Global Biotechnology Congress 2017 - Student Registration: Boston ... - Business Wire (press release)