FDA Grants Fast Track Designation to XyloCor Therapeutics Lead … – Business Wire (press release)

NEWTOWN SQUARE, Pa.--(BUSINESS WIRE)--XyloCor Therapeutics Inc., a privately held biotech company, today announced that the U.S. Food and Drug Administration (FDA) has grantedFast Track designation to its lead product candidate XC001 (AdVEGF-All6A+), a cardiovascular angiogenic gene therapy. XC001 is a one-time treatment being investigated for improving exercise tolerance in patients who have chronic angina that is refractory to standard medical therapy and not amenable to conventional revascularization procedures such as coronary artery bypass surgery and percutaneous coronary intervention and stents.

Achieving Fast Track status validates the need for XC001, which has the potential to be a unique treatment for this serious condition with high unmet need - chronic, refractory angina, said Al Gianchetti, President and Chief Executive Officer of XyloCor. This designation is supported by strong scientific evidence for XC001 and clinical validation of this mechanism of action in refractory angina. This important designation is intended to contribute to an expedited development and regulatory review process, which can get the drug sooner to patients who can benefit from it.

The FDA Fast Track designation is designed to facilitate the development and expedite the review of new drugs and vaccines intended to treat or prevent serious conditions and that demonstrate the potential to address an unmet medical need.

XC001 is a novel gene therapy that promotes angiogenesis, the formation of new vessels that can provide arterial blood flow to myocardial regions with inadequate blood supply. Enhancing myocardial blood flow with therapeutic angiogenesis is intended to relieve myocardial ischemia, improve regional and global left ventricular performance, alleviate angina symptoms and disability and potentially improve prognosis.

There are many patients in the United States with refractory angina and there are no available treatment options, said Magnus Ohman, Professor of Medicine, The Kent and Siri Rawson Director, Duke Program for Advanced Coronary Disease, Duke University School of Medicine. These patients have significant limitations in terms of their daily activities because of the chest pain associated with their ischemic disease and XC001 could be an important new option for them.

An IND for XC001 is open with the FDA and XyloCor intends to commence clinical trials upon funding.

About XyloCor

XyloCor Therapeutics is a private biopharmaceutical company developing novel gene therapy for people with unmet medical need from advanced coronary artery disease.XyloCor is focused on developing its lead product, XC001, for patients with refractory angina with no treatment options and its secondary product, XC002, for patients with cardiac tissue damage from heart attacks. XyloCor was founded by Dr. Ronald Crystal and Dr. Todd Rosengart, who both sit on XyloCors advisory board. Dr. Crystal is the Bruce Webster Professor and Chairman, Department of Genetic Medicine, Weill Cornell Medicine and Director of the Belfer Gene Therapy Core Facility.Dr. Rosengart is Professor and Chairman, DeBakey Bard Chair of Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine.XyloCor has a licensing agreement with Cornell University granting the company worldwide rights to develop, manufacture and commercialize XC001. With a strong scientific foundation, compelling preclinical and clinical evidence and an experienced team, XyloCor is poised for success and to help patients lead better, healthier lives. For more information, visit http://www.xylocor.com.

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FDA Grants Fast Track Designation to XyloCor Therapeutics Lead ... - Business Wire (press release)

A&S Outstanding Instructor Award Presented To Chemistry Lecturer – Yankton Daily Press

VERMILLION Kadarkaraisamy "Kadal" Mariappan, Ph.D., a lecturer in the Department of Chemistry at the University of South Dakota, is the 2017 recipient of the Outstanding Instructor Award presented by the College of Arts & Sciences.

After joining the chemistry department as a post-doctoral fellow in 2002, Mariappan began teaching laboratory courses as an instructor in 2005. He became a lecturer and chemistry teaching laboratory coordinator in 2007.

Mariappan teaches large lecture courses for students who are not majoring in chemistry and may have limited background in math and science.

"How do I make chemistry interesting for those students? The very first meeting of class I go over the importance of chemistry concepts," Mariappan said. "For example, I show them how the water molecule exists in liquid form because of one simple chemical interaction."

Mariappan says his approach to teaching the chemistry survey course for non-majors has spurred a greater interest in chemistry for some in his class. "There are usually a few students who change their majors to chemistry after the class," he said. "That means somebody listened."

With large lectures that start at 8 a.m., Mariappan also must encourage students to make it to class at an early hour. Short quizzes on the previous lecture or readings ensure attendance and Mariappan lets students discuss the questions and answers during the quiz. "They can work as a group to find the best answer," Mariappan said. "I tell them that education is not about grades but about training themselves to think."

The Outstanding Instructor Award is given annually to a faculty member in the College of Arts & Sciences who demonstrates outstanding classroom teaching and mentoring of students. The winner receives a cash prize, made possible through an annual gift of the Johnson family. Mary Elizabeth Johnson is a USD graduate in mass communication who served as Chaplain at the Mayo Clinic for over three decades, working closely with women experiencing health issues and loss. Johnson completed graduate work at Seattle University, and served as an adjunct member of the Mayo Medical School.

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A&S Outstanding Instructor Award Presented To Chemistry Lecturer - Yankton Daily Press

Act On Key Analyst Price Target Shifts: Puma Biotechnology, Inc. (PBYI), Windstream Holdings, Inc. (WIN) – USA Commerce Daily


USA Commerce Daily
Act On Key Analyst Price Target Shifts: Puma Biotechnology, Inc. (PBYI), Windstream Holdings, Inc. (WIN)
USA Commerce Daily
Shares of Puma Biotechnology, Inc. (NASDAQ:PBYI) are making a strong comeback as they have jumped 55.52% since bottoming out at $19.74 on May. 10, 2016. Meanwhile, due to an ongoing pressure which caused a decline of almost -24.38% in the past ...

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Act On Key Analyst Price Target Shifts: Puma Biotechnology, Inc. (PBYI), Windstream Holdings, Inc. (WIN) - USA Commerce Daily

Animal Biotechnology Technologies, Markets and Companies 2016-2026 With Profiles of the Top Companies … – PR Newswire (press release)

This report describes and evaluates animal biotechnology and its application in veterinary medicine and pharmaceuticals as well as improvement in food production. Knowledge of animal genetics is important in the application of biotechnology to manage genetic disorders and improve animal breeding. Genomics, proteomics and bioinformatics are also being applied to animal biotechnology.

Transgenic technologies are used for improving milk production and the meat in farm animals as well as for creating models of human diseases. Transgenic animals are used for the production of proteins for human medical use. Biotechnology is applied to facilitate xenotransplantation from animals to humans. Genetic engineering is done in farm animals and nuclear transfer technology has become an important and preferred method for cloning animals.There is discussion of in vitro meat production by culture.

Biotechnology has potential applications in the management of several animal diseases such as foot-and-mouth disease, classical swine fever, avian flu and bovine spongiform encephalopathy. The most important biotechnology-based products consist of vaccines, particularly genetically engineered or DNA vaccines. Gene therapy for diseases of pet animals is a fast developing area because many of the technologies used in clinical trials humans were developed in animals and many of the diseases of cats and dogs are similar to those in humans.RNA interference technology is now being applied for research in veterinary medicine.

Molecular diagnosis is assuming an important place in veterinary practice. Polymerase chain reaction and its modifications are considered to be important. Fluorescent in situ hybridization and enzyme-linked immunosorbent assays are also widely used. Newer biochip-based technologies and biosensors are also finding their way in veterinary diagnostics.

Approximately 124 companies have been identified to be involved in animal biotechnology and are profiled in the report. These are a mix of animal healthcare companies and biotechnology companies. Top companies in this area are identified and ranked. Information is given about the research activities of 11 veterinary and livestock research institutes. Important 108 collaborations in this area are shown.

Share of biotechnology-based products and services in 2016 is analyzed and the market is projected to 2026.

The text is supplemented with 35 tables and 5 figures.Selected 260 references from the literature are appended.

Key Topics Covered:

Executive Summary

1. Introduction to Animal Biotechnology

2. Application of Biotechnology in Animals

3. A Biotechnology Perspective of Animals Diseases

4. Molecular Diagnostics in Animals

5. Biotechnology-based Veterinary Medicine

6. Research in Animal Biotechnology

7. Animal Biotechnology Markets

8. Regulatory issues

9. Companies Involved in Animal Biotechnology

10. References

For more information about this report visit http://www.researchandmarkets.com/research/mdr33b/animal

About Research and Markets

Research and Markets is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

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Laura Wood, Senior Manager press@researchandmarkets.com

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To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/animal-biotechnology-technologies-markets-and-companies-2016-2026-with-profiles-of-the-top-companies---research-and-markets-300452977.html

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Animal Biotechnology Technologies, Markets and Companies 2016-2026 With Profiles of the Top Companies ... - PR Newswire (press release)

The Tech Museum of Innovation wins national honor for BioDesign Studio exhibit – GlobeNewswire (press release)

May 08, 2017 11:56 ET | Source: The Tech Museum of Innovation

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San Jose, CA, May 08, 2017 (GLOBE NEWSWIRE) -- The Tech Museum of Innovation has earned one of the nations top honors for museum experiences. BioDesign Studio, an exhibit The Tech opened in 2016, won Silver for Interpretive Interactive Installations at the Media and Technology MUSE Awards, presented by The American Alliance of Museums at a celebration Sunday night.

We developed BioDesign Studio to make bioengineering playful, fun and approachable. Were thrilled to have national recognition of this ambitious effort, says Anja Scholze, Experience Developer and Program Manager, Biotech & Health, who accepted the award at AAMs annual meeting. It was a daunting task to design experiences that would empower everyone, from grade-schoolers to retirees, to explore a complex topic like bioengineering. A year later, its humbling to see our visitors walk away with a new understanding and enthusiasm for the possibilities of biotechnology and their own role in it.

BioDesign Studio is a permanent exhibit with an array of hands-on experiences that encourage visitors to play, tinker and design with the building blocks of life. At the Creature Creation Station, visitors use custom blocks representing genetic traits to build creatures and unleash them in a digital world where they interact with other organisms. In the Living Colors Lab, they use real lab equipment to alter the DNA of bacteria to change its color, and in the BioTinkering Lab they participate in bioengineering projects like creating bricks using mycelium, or mushroom root, a sustainable building material. The goal is to spark a sense of wonder about the worlds most complex technology: biology.

Bioengineering plays an important role in solving many of the worlds biggest problems like hunger and climate change. Were so happy to see BioDesign Studio visitors not only learning about synthetic biology, but starting to see their own potential to create with it, said Gretchen Walker, Vice President of Learning at The Tech.

The MUSE Awards competition received more than 200 applications from a wide variety of institutions in North and South America, Europe, Australia and Asia. This years entries included videos and films, interactive kiosks and installations, VR experiences, applications and APIs, digital communities, websites, audio tours and more.

"We're so pleased to have received this recognition- we worked hard with the brilliant team of scientists at The Tech to create an exhibit about synthetic biology that could last 10 years. We can't wait to see the new life forms, biological and digital, that visitors create in the years to come," said Ben Millstein, Communications Manager of Local Projects, a New York firm that helped The Tech design the exhibit.

Over 90 GLAM (Galleries, Libraries, Archives and Museums) professionals from across the globe participated as jurors in the process of reviewing and scoring entries. Winning programs demonstrate outstanding achievement in their content, interface, design, technical merit, innovation, utility and appeal.

Now in its 28th year, the MUSE awards competition recognizes outstanding achievement in GLAM media and technology efforts. The competition is led by the American Alliance of Museums Media & Technology Professional Network. For more information about the MUSE awards, visit: http://aam-us.org/about-us/grants-awards-and-competitions/muse-awards

For more information on BioDesign Studio, visit thetech.org/biodesignstudio.

For pictures of BioDesign Studio, click here.

Media Contact: Marika E. Krause | 408-591-0027 | mkrause@thetech.org

About The Tech Museum of InnovationThe Tech is a hands-on technology and science museum for people of all ages and backgrounds. The museum located in the capital of Silicon Valley is a non-profit experiential learning resource established to engage people in exploring and experiencing applied technologies affecting their lives. The Tech Challenge and Tech Awards are signature programs of The Tech. The Techs mission is to inspire the innovator in everyone. Visit thetech.org for more info.

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The Tech Museum of Innovation wins national honor for BioDesign Studio exhibit - GlobeNewswire (press release)

Scientists watch fat metabolism in live fish, observe real-time lipid biochemistry – Phys.Org

May 8, 2017 A live image of the liver of a translucent, larval zebrafish. It was taken using confocal microscopy, which allows for clear images of the internal organs of a whole live animal. Quinlivan fed a fluorescently tagged fatty acid to a larval zebrafish and then photographed its liver at 400x magnification. The round dots of varying sizes are lipid droplets, which contain a kind of fat called triglyceride. These triglycerides were constructed using the fluorescent fat consumed by the larval zebrafish. Fluorescence also shows up in the gallbladder (GB) and developing kidney (K). Credit: Vanessa Quinlivan

Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as well as reveal basic cellular functions. But the process of studying what happens to lipids after being consumed has been both technologically difficult and expensive to accomplish until now.

New work from Carnegie's Steven Farber and his graduate student Vanessa Quinlivan debuts a method using fluorescent tagging to visualize and help measure lipids in real time as they are metabolized by living fish. Their work is published by the Journal of Lipid Research.

"Lipids play a vital role in cellular function, because they form the membranes that surround each cell and many of the structures inside of it," Quinlivan said. "They are also part of the crucial makeup of hormones such as estrogen and testosterone, which transmit messages between cells."

Unlike proteins, the recipes for different lipid-containing molecules are not precisely encoded by DNA sequences. A cell may receive a genetic signal to build a lipid for a certain cellular purpose, but the exact type may not be indicated with a high degree of specificity.

Instead, lipid molecules are built from an array of building blocks whose combinations can change depending on the type of food we eat. However, lipid compositions vary between cells and cellular structures within the same organism, so diet isn't the only factor determining which lipids are manufactured.

"Understanding the balancing act in what makes up our bodies' lipidsbetween availability based on what we're eating and genetic guidanceis very important to cell biologists," Farber explained. "There is growing evidence that these differences can affect wide arrays of cellular processes."

For example, omega-3 fatty acids, which are lipid building blocks found in foods like salmon and walnuts, are known to be especially good for heart and liver health. There is evidence that when people eat omega-3 fatty acids, the cellular membranes into which they are incorporated are less likely to overreact to signals from the immune system than membranes comprised of other kinds of lipids. This has an anti-inflammatory effect that could prevent heart or liver disease.

Farber and Quinlivan's method allowed them to delve into these kinds of connections. They were able to tag different kinds of lipids, feed them to live zebrafish, and then watch what the fish did with them.

"If we fed the fish a specific type of fat, our technique allowed us to determine into what molecules these lipids were reassembled after they were broken down in the small intestine and in which organs and cells these molecules ended up," Farber explained.

The tags they used were fluorescent. So Farber and Quinlivan and their team were actually able to see the fats that they fed their zebrafish glowing under the microscope as they were broken down and reassembled into new molecules in different organs. Further experiments allowed them to learn into what types of molecules the broken down fat components were incorporated.

"Being able to do microscopy and biochemistry in the same experiment made it easier to understand the biological meaning of our results," Quinlivan said. "We hope our method will allow us to make further breakthroughs in lipid biochemistry going forward."

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Scientists watch fat metabolism in live fish, observe real-time lipid biochemistry - Phys.Org

Special Report Preview: Anatomy of a Rape – WILX-TV

LANSING, Mich. (WILX) Its a tough crime to measure and a tough crime to prosecute. But Ingham Countys prosecutor says rape cases can be prevented with the right kind of education. Carol Siemon said, I think its huge, unless we change public perception, about what sexual assault looks like, cause I want to prevent it. Im not looking for successful prosecutions.

Just weeks into her new reign as prosecutor, Siemon was handed two cases involving MSU football players. No charges have been issued in the first case, alleged in January. Charges in the second case, alleged in early April, were announced 2 weeks later. This has many people casting doubt about the first case, asking why its taking so long for the prosecutor to investigate.

Prosecutor Siemon says its nothing new to her. She has years of experience prosecuting sexual assault. I think that we focus way too much on the victim, our laws do, our public perceptions do, on the victim's responsibility, and not on the person who is initiating the sexual activity.

Siemon sits down with News 10s Ann Emmerich to talk about her philosophy on prosecuting sexual assault cases, and what she thinks can help prevent the crime. Watch Anatomy of a Rape Tuesday on News 10 at 6.

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Special Report Preview: Anatomy of a Rape - WILX-TV

The Anatomy Of Change Argentina’s Macri Undoing Years Of Damage – Frontera News

On 10th December 2015, over a year ago, Macri assumed office as President of Argentina from the complicated Cristina Fernandez de Kirchner. Kirchner and her late husband who was President for almost four years preceding his wife had many successes and failures during their time at the helm, but it was clear that things were heading down a dangerous path in Argentina.

During Kirchners tenure, inequality, as defined by the GINI coefficient declined by 20% (see figure below), this was laudable as it was also matched by an increase in median household income from ~$1,300 annually to ~$2,700 in 2015, that is annual growth of 6.2% which is commendable, but what this statistic conceals is that median household income reached a peak of ~$5,700 in 2013 and fell -47% since. This is largely caused by currency problems, as the Argentinean Peso during the Kirchners time fell -70%. This was in spite of hard-fought efforts by Christina Kirchner to control the value of the currency.

The Kirchners mix of socialism, populism, and authoritarianism detrimentally impacted Argentinas image abroad. Image is not simply a branding exercise but also resulted in poor levels of foreign investment. One of the major reasons for a sharp drop in foreign investment in the latter part of Christina Kirchners presidency was her erratic decision to nationalize YPF, Argentinas national oil producer which had been privatized in 1993. This was done without any negotiations with Repsol, the other owner of YPF. YPFs performance declined substantially and forced Argentina to import energy, creating an inflation spike.

Areas of improvement where the Kirchners did do well, include an improvement in education and access to healthcare. However, this was balanced by targeting farmers with excessive taxes, particularly on soybeans and currency controls which had a very material negative impact on the average Argentinean. In the Kirchners worldview, the economy was a system where certain parties exploited other groups. There was no vision or infrastructure to allow the economy to grow where all segments of the population could improve their lives.

In this environment, Macri took over, the former Mayor of Buenos Aires and a sharp capitalist who was ready for shifting Argentina away from disastrous policies which favored present consumption at the expense of future growth. One of Macris first steps was to remove all currency controls and allow the currency to freely float. The result was a 1-day drop of the currency by -30% causing significant pain to the economy. Important to keep in mind though, that most Argentines were never able to transact FX at the official rate, and this drop after Macri removed controls is more reflective of the actual effective FX rate. Controls are impossible to maintain when there is limited confidence in your currency and you lack any firepower in terms of FX reserves to maintain your controls.

Macri cut export taxes on several commodities including major cash crops such as beef, wheat, and corn. Macri also reduced export taxes for soybeans by 5%. This was done in his first week in office. The impact of this was significant, for example, corn exports increased 21% in 2016, and beef by 13%. He could have certainly done more, but this was useful in placating angry farmers, and nobody wants angry farmers.

Related Article Lenins Ecuador: What Lies Ahead In Latin America?

In April 2016, Macri ended a 15-year saga that Kirchner had made a farce, by agreeing to pay $9.3 billion to holders of Argentinas notes that the country defaulted on[7]. In one action, Macri won the respect of international investors and built credibility for the new government, allowing Argentina to borrow $16.5bn and later another $20bn from international markets.

During the Kirchner years, there was a lot of tension between the Central Bank and her office. She removed two heads of the Central Bank and completely comprised the independence of the Central Bank. Macri has reasserted the independence of the Central Bank and a noticeable pivot has been made to inflation targeting. The Central Bank recently maintained its benchmark interest rate at 24.75% to target inflation between 12 17% in 2017.

Macri has been fortunate with a victory for Trump. Trump and the Macri family go way back to a real estate deal in New York which is outlined in Art of the Deal. We can expect materially better relations between the two countries and foreign investment from the United States over the next 4 8 years. The two met last week and by both accounts, the meeting went well. Exports to the US in 2016, under Macri were up 30%, primarily due to biodiesel sales.

Macris work is just getting started and he does not wield a tremendous amount of power, given lackluster economic performance last year from the economy turning around and limited control for his party. However, indications are that inflation is now under control and we can expect up to 2.2% GDP growth in 2017.

Argentina has a material amount of natural resources, including significant gold, copper, oil and natural gas. Major projects have long been delayed such as Pascua Lama, and shale field Vaca Muerta. Macri needs to ensure that major energy companies are secure and that investments will be respected within the laws of Argentina.

Macri would like to reorient the economy towards technology, this will be a significant challenge. Within Latin America, Brazil, Mexico, and Chile are eons ahead of Argentina. They have developed a strong ecosystem for startups, innovation, and education. Argentina has languished for more than a decade under Kirchner and suffered a significant brain drain with Argentines going abroad for education and often staying there.

The reception for Macri has been largely positive from the international community because Argentina was being operated so terribly. Someone halfway decent who is sane is very welcome. To draw an extreme parallel, if Maduro in Venezuela or Kim in North Korea are replaced by a sane person, no matter how they err, they will be heroes internationally.

Macri has his share of corruption, such as the debt forgiveness of his own company.He may also ignore the needs of those hoping to remove barriers towards upward mobility in Argentinian society and weaken the advances that Argentinas indigenous population have made. These failures are what we worry the most about. The stock market in Argentina is up 80% since he took office and the currency has stabilized. We remain very optimistic about the future of Argentina for now.

This article was written by Investment Frontier.

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The Anatomy Of Change Argentina's Macri Undoing Years Of Damage - Frontera News

Anatomy of a Budget Breakdown – The Exponent Telegram (press release) (registration)

It wasnt as if he hadnt tried to warn them.

For weeks, House Speaker Tim Armstead, R-Kanawha, had been telling anyone who would listen that the Republican majority in the House of Delegates would not go along with any state revenue or budget plan that included tax increases for the citizens of West Virginia.

Our families are struggling to make ends meet, and this is absolutely the wrong time to burden them with hundreds of millions of dollars in additional taxes Armstead said.

Apparently, neither Democratic Gov. Jim Justice nor Senate President Mitch Carmichael, R-Jackson, was listening. On Thursday, May 4, Justice called the Legislature into special session to consider revenue and tax reform measures aimed at passing a state budget. That revenue plan included raising the state sales tax from 6 to 7 percent, raising gasoline taxes and fees for services at the Division of Motor Vehicles and raising taxes on corporations and the very wealthy.

When the special session began at 11 a.m. May 4, the revenue bill was not ready. But by mid-afternoon, a copy of the legislation had been filed. When the House of Delegates reconvened shortly after 5 p.m. following an afternoon break, delegates took up the bill, read it a first time, then took an unexpected move they quickly rejected the proposal on its first reading by a vote of 59-36.

Three bills introduced in the Senate earlier in the day were still in play, however. Those measures would provide for a 2 percent teacher pay raise, raise gasoline taxes and DMV fees and allow for increasing tolls on the West Virginia Turnpike. But the House move to reject Justices tax reform and revenue bill effectively scuttled any attempt to reach a budget agreement on the first day of the special session. The House and Senate were set to reconvene Friday, but Armstead and others said there was little point in trying to continue business until another budget deal can be reached.

For now, I think its best we take a break and get everyone in a room and try to work out our differences, Armstead said on May 4. I encourage Gov. Justice to listen to the message the House sent tonight and work with our leadership team and our colleagues in the Senate to find a path forward that will truly work for the people of West Virginia.

Justices Plan

Justice vetoed the budget the Legislature passed in the waning hours of the regular legislative session. That bill would have made cuts to higher education and the state Department of Health and Human Resources and would have required taking about $90 million from the state rainy-day fund, a move that would have brought the balance in the fund below recommended levels and likely would have resulted in a lowering of the states bond ratings.The revenue proposals Justice presented for the special session call did not differ significantly in principle from the plan the governor presented before the regular session began in February. Justices plan included a 1 percent increase in the sales tax, temporary tax increases on the most wealthy West Virginians, a tiered severance tax system for the coal and natural gas industries that would allow company owners to pay less tax when times are bad but pay more when times are good, increasing corporate taxes and raising tolls, DMV fees and gasoline taxes to fund a massive road construction program Justice has said would create 48,000 jobs.But in a compromise negotiated between members of Justices administration and Republican leadership in the Senate, the proposal killed by the House of Delegates May 4 also included a statewide tax reform plan similar to one that had been studied in the Senate.That proposal would have allowed for lower personal income tax rates for state residents, with the possibility of eliminating personal income taxes completely. Carmichael said phasing out the personal income tax even with the hike in the sales tax would mean an aggregate $100 million tax cut for the citizens of the Mountain State.Its a win-win, Carmichael said.

Revenue projections prepared by the state Department of Revenue showed phasing out the income tax would end up costing the state more than $100 million a year in revenue following the first couple of years. Carmichael, however, is convinced doing away with personal income taxes would spur economic growth, give West Virginians an incentive to go back to work and more than make up for any short-term loss in revenue.

Opposition Builds

Armstead and other House Republicans were against the governors revenue and budget plans even before the special session was announced.On the final day of the regular session, Justice called a news conference to announce he had worked out a compromise deal with leaders in the Senate, two hours before the end of the session, to pass a budget bill containing most of the governors original proposals. A budget amendment sponsored by Senate Majority Leader Ryan Fern, R-Ohio, contained most of Justices revenue proposals except the tiered severance tax.The Ferns amendment was not the budget bill ultimately passed by the Legislature and vetoed by the governor, but served as the basis for the revenue and budget proposals planned for the special session.House of Delegates spokesman Jared Hunt said the budget negotiations between Justice and the Senate were made without the participation or knowledge of members of the House. Armstead criticized the governor several times for leaving House Republicans out of budget talks.Armstead also issued a series of statements warning Justice and the Senate that House Republicans would not go along with any tax increase. He was joined by other members of the House of Delegates.

Members of the Libertarian-leaning Liberty Caucus came out publicly against the governors revenue and budget proposals.

For years we have fought efforts to raise taxes and grow government, and the plan the governor and Senate are trying to push would do just that, said Delegate Pat McGeehan, R-Hancock. While we like the idea of lowering the income tax, the idea of offsetting it with even higher sales and business taxes will only hurt our economy particularly in border areas.

Republican delegates from many of the states border counties also opposed raising the sales tax, fearing it would hurt business.

Politicians in Charleston do not understand how easy it is for people in the panhandles to cross the border to shop, said Delegate Jill Upson, R-Jefferson. Pushing our sales tax significantly higher than our neighboring states will put our retailers at a disadvantage and drive more business out of our state.

Delegates from southern coal-producing counties also opposed the plan because of Justices severance tax proposals.

Just as President Donald Trump begins to fulfill his promise to put the miners back to work, our governor wants to shove through a tax plan thats going to put some coal mines and coal miners out of business, said Delegate Zack Maynard, R-Lincoln. The industry and our region are just now starting to see the light at the end of the tunnel, and Im going to fight any proposal that could halt that recovery and cost us coal jobs.

Some outside observers also thought Justices revenue and budget plans were a bad idea. Sean OLeary, a policy analyst for the left-of-center West Virginia Center on Budget & Policy, said the changes in income tax brackets under the revenue proposal would end up being a tax increase for 80 percent of state residents, while creating a tax cut for those in the upper 20 percent of wage-earners.

OLeary also said eliminating personal income taxes would not lead to economic growth or put people back to work.

He said states that dont have an income tax make up for the lack of revenue in other areas, such as higher property taxes or sales taxes.

The idea that somehow West Virginia is going to be different from all these other states that have tried this and failed is not borne out by evidence, OLeary said.

House opposition to Justices revenue and
budget proposals ended in a scathing criticism of his handling of the special session.

The governor knew the votes were not there to pass his tax increases and that calling this special session today was premature, Armstead said May 4. Now were here in Charleston wasting $35,000 a day and dont even have the key bill we need to consider.

If theres one thing we know taxpayers hate, its seeing the Legislature sitting around wasting time in special session, agreed Majority Leader Daryl Cowles, R-Morgan. This governor campaigned on limiting the time we could spend in special session, and now were here in Charleston sitting on our hands because he hasnt even submitted the key bill were supposed to consider.

Strategic Miscalculation?

While it is not unusual for the governor to call a special legislative session to finish work on the budget, former state Revenue Secretary Bob Kiss also a former speaker of the House of Delegates said the governor typically has a basic agreement in place with the House and Senate before calling lawmakers into session. House Minority Leader Tim Miley, D-Harrison, who also spent time as House speaker, said last year was the first time in his memory the Legislature went into special session to work on the budget without an agreement already in place.Last year was also the first time in more than 80 years that West Virginia had a Democratic governor and a Republican-controlled Legislature. But given the massive budget deficits and financial problems the state faces, Kiss isnt sure the trouble reaching a budget agreement can be pinned solely on political differences.Up until 2006, some of the minutia of funding state agencies was taken care of in the state Budget Digest, worked out after the Legislature passed the budget. To some extent, that arrangement allowed lawmakers to make general appropriations for state agencies, but leave divvying up the money to the Budget Digest.But, as complicated as the Mountain States financial situation is today, neither Miley nor Kiss thinks the continued existence of the Budget Digest would have made passing a budget any easier.A number of observers in the state Capitol believe Justice may have miscalculated his strategy for passing a budget. While they support the governors proposals, some Democrats have quietly said Justice may have picked the wrong method to get his messages across.

Some Democrats wondered if Justice, used to getting his way, may have thought he could cut a budget deal with the Senate and either shame or bully the House of Delegates into going along with the plan.

Justice spokesman Grant Herring did not respond to a request for comment.

Justices management style apparently did not win him much support with House Republicans for this round.

This is what happens when you dont listen to people or consider all sides in a negotiation, said House Finance Committee Chairman Eric Nelson, R-Kanawha. Weve wanted to talk about these items over the last couple of weeks, but the governor shut the door in our faces. Now hes called us back into session, and we learn there are still issues to work out. This is a colossal waste of time and taxpayer money.

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Anatomy of a Budget Breakdown - The Exponent Telegram (press release) (registration)

Laura Caldwell and Antione Day on Anatomy of Innocence: Testimonies of the Wrongfully Convicted – WGN Radio


WGN Radio
Laura Caldwell and Antione Day on Anatomy of Innocence: Testimonies of the Wrongfully Convicted
WGN Radio
About five percent of people who are convicted of a crime in the US are, in fact, innocent. Laura Caldwell seeks to bring awareness to this with a new chilling, but hopeful collection of true stories, Anatomy of Innocence: Testimonies of the ...

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Laura Caldwell and Antione Day on Anatomy of Innocence: Testimonies of the Wrongfully Convicted - WGN Radio

Grey’s Anatomy Photo Preview: Mer, Riggs, and a Kid Makes Three – TV Fanatic

Cute kid alert!

On Grey's Anatomy Season 13 Episode 23, Nathan and Meredith will take on a case involving a wise beyond her years patient who wants to know the ends and outs of her condition and her treatment. She certainly seems to be impressing Riggs.

Meredith and Nathan appear to have their first couple's quarrel about the course of the case. Even Meredith can't help but smile at Nathan and their tiny human patient. That's a good sign, seeing as she has a brood of tiny humans herself.

Elsewhere, Alex is at a medical conference looking especially dapper in a gray suit. The question is, what is in that file of his he is carrying around and does it have anything to do with that mysterious phone call he made at the end of Grey's Anatomy Season 13 Episode 22?

Owen gets a surprise of his own when someone comes knocking at his door. It has to be about his sister, right?!

Check out the photos below and hit the comments with your theories. Need to catch up? No problem, you can watch Grey's Anatomy online here via TV Fanatic!

This young patient knows her way around an X-Ray. Is she a future doctor in the making?

It's Alex's turn to take a trip out of town for a medical conference.

Meredith interrupts while Nathan bonds with his tiny human patient.

Nathan's next case may involve saving this little cutie.

Mer and Nathan are on a case together and have a friendly debate on how to handle it.

Alex is professionally dressed with luggage in hand. What will Alex find out at this medical conference?

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Grey's Anatomy Photo Preview: Mer, Riggs, and a Kid Makes Three - TV Fanatic

Social Security Knowledge Center: What does longevity have to do … – Northeast Mississippi Daily Journal

According to the 2015 Social Security report, less than 7 percent of people with enough quarters to draw their Social Security benefit died prior to receiving. There are three other groups of individuals that will not receive benefits infrequent workers who do not have sufficient earnings to qualify for benefits, non-covered workers such as state and local government employees who did not pay into the program and immigrants who arrive in the United States at 50 or older and therefore have not worked long enough to qualify for benefits.

Benefits are affected by how long you live, which is changing with every new breakthrough in the medical field. Life expectancy data is changing as well one of every four 65 years olds will live past age 90. The average life expectancy in the U.S. for men is 85 years old and for women, it is 88 years old. As we talk to clients, most people are more concerned about dying early, than living too long. This is a mindset that needs to be discussed.

As you get older, the cost of medical expenses increases. That is why it is so important when looking at your Social Security benefit, to have a professional present options that will improve your Survivor benefit. When one member of a married couple dies, only one check is remaining the higher of the two. So, it only makes sense to try and improve this benefit. Statistically, women outlive men so, you are looking at years of additional income needed for the spouse, that is now compromised by receiving only one check, not two. Thats a big difference.

Therefore, we tell people they need a plan Social Security should not be taken just because you are entitled to receive it. When, how and why need to be factored into your decision.

Roy and Diane Thompson are both National Social Security Advisors, and Roy is a former CPA of 40 years. The couple lives in Corinth and can be reached at (601) 954-0699 or at dthompson@pillarsllc.com. For more information, visit http://www.pillarsllc.com.

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Social Security Knowledge Center: What does longevity have to do ... - Northeast Mississippi Daily Journal

NEET physics 'tough', some biology questions stump many – Times of India

PUNE: The National Eligiblity-cum-Entrance Test (NEET) for admissions to medical and dental colleges passed off smoothly in the city on Sunday. Nearly 50,000 students appeared for the exam from Pune and nearby areas.

For most of the students, however, physics was a tough paper to crack. They also said that about four to five questions in the biology paper seemed to be out of syllabus. Chemistry, however, they said, was easy.

The Central Board of Secondary Education (CBSE) conducted the NEET, which contained three papers of a total 720 marks.

The exam was simultaneously held at 104 centres in 11 cities in the state, including Pune and Mumbai.

Hritik Patil, one of the candidates at the S M Choksey College exam centre, said, "The biology paper carried the highest marks. As a few questions seemed out of syllabus, it is a cause of worry. These questions were worth 20 to 30 marks."

Link:
NEET physics 'tough', some biology questions stump many - Times of India

Stanford biologist Robert Sapolsky takes on human behavior, free will – Stanford University News

Robert Sapolsky (Image credit: L.A. Cicero)

Robert Sapolsky is a lot of things: a MacArthur Fellow who spent years studying a troop of baboons in Kenya, a neuroendocrinologist who changed the way we think about stress and the brain, an accomplished columnist and writer of popular science books. He is also a professor of biology at Stanford who has long been interested in what animals can tell us about our own behavior.

Most recently, Sapolsky has been reflecting on the origins of human behavior, starting deep in the brain moments before we act and working his way millions of years back to the evolutionary pressures on our prehistoric ancestors decisions, with stops along the way to consider how hormones, brain development and social structures shape our behavior. He also has been thinking about free will and comes to the conclusion, based on the biological and psychological evidence, that we do not have it.

On the occasion of his latest book, Behave: The Biology of Humans at Our Best and Worst, Stanford News Service interviewed Sapolsky about science, the need to be behavioral biologists and what to do about justice if, as Sapolsky argues, we do not have free will.

Youve advanced the idea that we cant understand human behavior by studying it at just one level that, for example, we cant understand politics without studying neurons, brain chemistry without studying psychology, or perhaps even humans without studying apes. Does that mean that weve been studying behavior the wrong way? Are university departments too compartmentalized to see the forest for the trees?

Well, theres nothing particularly special about the idea scientists thinking about the bases of behavior know that you have to be multidisciplinary. There are entire journals that enshrine that concept, for example, Psychoneuroimmunology or Brain, Behavior and Evolution, and every university of note is overflowing with interdisciplinary programs.

Where the contrast comes in is with individual scientists research. Of necessity, a scientist typically studies one incredibly tiny sliver of some biological system, totally ensconced within one discipline, because even figuring out how one sliver works is really hard. There are not many scientists who would argue that their sliver is the only thing that should be studied just that its the most important, which sure makes sense, if they just spent their last seven decades obsessing over that sliver.

Is that a problem?

Its not a problem if all they do is talk and think about sliver X. But potentially a definite problem if they think larger and their sliver X-centric view of the universe is distorted.

All roads in human behavior seem to lead to its complicated. Out of the mess of things that combine to create our best and worst and typical behavior, what do you think is most important for ordinary people to know? What about policymakers or other scientists?

I think its the same for both groups, which is that were all behavioral biologists when we serve on juries, when we vote for whether government funds should be spent to try to correct some societal ill, when we deal with an intimate with a mental illness, we are tacitly deciding how and how much our behavior is constrained by biology. So we might as well be informed behavioral biologists. And one thing that involves is being profoundly cautious and humble when it comes to deciding you understand the causes of a behavior, especially one that we judge harshly.

What does that suggest about judicial sentencing rules or the death penalty, for example?

Basically, that the criminal justice system is staggeringly out of date in incorporating neuroscience into its thinking. As one flagrant example, the gold standard for determining whether someone is so organically impaired that they cant be held responsible for their criminal actions the MNaghten rule concerning an inability to tell the difference between right and wrong is based on the case of a man by that name, almost certainly a paranoid schizophrenic, from the 1840s. The 1840s!

What are the most important questions that remain?

For me, the single most important question is how to construct a society that is just, safe, peaceful all those good things when people finally accept that there is no free will.

Thats a tall order, given that philosophers let alone politicians and activists have trouble deciding what justice and free will mean.

A tall order, indeed, because words like justice, punishment, accountability become completely irrelevant as irrelevant as if a car that has damaged brakes and is dangerous to drive is thought to be accountable for being dangerous, and that justice is served when the car is punished by locking it up in a garage and not driven.

And its equally important and challenging to realize that free will is also irrelevant to our best as well as our worst behaviors. And thus where praising seems as irrelevant as praising a car for having a strong work ethic and admirable gratification postponement when it makes it up the top of a steep road. Or if you give a car preferential treatment if it was manufactured with a really attractive hood ornament.

Yes, a very tall order, and Im not sure if it is achievable.

Sapolsky is also a professor of neurology and neurological sciences and of neurosurgery, and a member of Stanford Bio-X and the Stanford Neurosciences Institute.

Continued here:
Stanford biologist Robert Sapolsky takes on human behavior, free will - Stanford University News

Co2re gives you clear, perfectly smooth skin – Palm Beach Post

Question: How I can achieve dramatic, clear and smooth skin results?

Answer: Sun spots, wrinkles, enlarged pores, acne scarring and skin laxity are concerns of men and women of all ages. It used to be difficult to select the appropriate technology for each concern, as lasers are usually specific to only one condition. Patients used to have to undergo not just a series of treatments, but also a few different lasers to address all concerns.

The latest technology for skin resurfacing is the new Co2re laser by Syneron Candela, a very efficient and versatile laser for skin resurfacing with minimal downtime. Fractional lasers only treat a fraction of the skin at a time with microscopic laser beams, as they drill millions of holes in the skin creating columns of injury that heal with new and healthy skin. The depth of laser penetration determines what is being treated and the downtime.

Almost every medical spa offers fractional resurfacing, fraxel, profractional and active fx, to name a few but Co2Re is truly innovative in that it uses seven types of laser beams that penetrate different depths at the same time.

This means that various conditions can be treated simultaneously. It has up to seven treatment modes to treat a variety of skin issues, from dark sun spots to deep wrinkles and acne scarring. In addition, Co2re offers dramatic results with minimal discomfort after just one treatment.

For patient comfort, we apply anesthetic cream to the face 20 minutes prior to the procedure. Generally significant improvement may be achieved after only one treatment, but ultimately all patients have different needs and will have to be assessed during their consultations. For more information, call 561-655-6325.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

________________________________________

MD Beauty Labs Medical Spa and Wellness Center

320 S. Quadrille Blvd., West Palm Beach

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Co2re gives you clear, perfectly smooth skin - Palm Beach Post

Human Genetic Engineering on the Doorstep – hgalert.org

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Read more here:
Human Genetic Engineering on the Doorstep - hgalert.org

Amazing genetics – The News International

With the world population expected to reach nine billion by 2050, and with limited cultivable area on our planet, there is an increasing probability of droughts and mass famines in many countries.

Pakistan will be among those countries that will be most seriously affected by global warming. The spectacular advances in genomics in the last few decades offer some beacon of hope. The development of genetically-engineered crops will give increased yields, offer better nutrition and be resistant to diseases.

All the hereditary information in plants or animals is contained in their genes. Think of a tiny microscopic necklace (DNA) with many millions or billions of four different types of molecules known as nucleic acids arranged in it. It is the sequence in which these nucleic acids are arranged that determines everything about living organisms, such as the types and qualities of fruits that plants bear, the colour of our eyes, the structure of our hearts or brains, etc. The order in which these molecular beads are arranged is known as the genetic code. The first such code in humans to be unravelled was that of Prof Jim Watson in 2007. It cost about a million dollars and took years to accomplish. With faster sequencing machines now available, this can be done within a week at a cost of about $1,500 today.

A remarkable breakthrough has now been made by scientists at Imperial College, London. They have developed a microchip that can allow the sequencing to be done at an incredible speed the entire genome of 3.16 billion nucleic acids in human beings can be read and deciphered within minutes. The device in which the chip is incorporated reads the small changes in current as the molecular necklace passes through it. It is being scaled up so that it can read the sequence of molecules at a speed of 10 million molecules per second (compared to the present machines that can read the sequence at 10 molecules per second).

Another amazing development has been the identification of crime genes in hardened criminals. The presence of the gene restricts the formation of serotonin B2 receptor, and so affects the part of the brain that is responsible for restraint and foresight of the consequences of ones actions. The presence of the gene increases the predisposition to violence. However, all the people carrying the gene are not necessarily violent. Other psychological causes may also be responsible for violent behaviour.

A few years ago, researchers at Kings College London had identified certain genes that are responsible for the ageing process in human beings. They found that these genes are switched off and on by certain external factors, such as diet and the environment, and may hold the keys for living a longer and healthier life. The four key genes that affected the rate of healthy ageing and potential longevity were related to cholesterol, lung function and maternal longevity.

A research group at ETH Zurich discovered that when certain ageing genes are altered, the healthy lifespan of laboratory animals can be extended significantly. Efforts to achieve something similar in human beings are under way and many scientists believe that our children may be able to live up to the age of 120 years. In 2016, the US Food and Drug Administration (FDA) approved an anti-ageing drug trial. This was the first time the FDA recognised ageing as a new drug target

Over 200 million people are afflicted with malaria each year and nearly 800,000 deaths are recorded due to it every year. Over 90 percent of these deaths mostly of chidren occur in Sub-Saharan Africa. An exciting approach to tackle this disease is to develop genetically modified mosquitoes that can bring down the population of the harmful female variety. Anthony James, working at the University of California Irvine, has developed a genetically-modified variety of these female mosquitoes only. The genetic deformation prevents them from flying. The larvae hatch on water but the females cannot fly, and therefore die.

This approach of genetic genocide may ultimately help to reduce the populations of malaria-causing mosquitoes and save millions of lives. The advances made in the rapid sequencing of the human genome are leading to a greater understanding of the genetic causes of many human diseases. A whole new area of personalised medicine is also under rapid development. This will allow drugs to be tailored according to individual genetic make-up of different groups of populations.

An excellent centre for genetic engineering has now been established in Pakistan. The Jamil-ur-Rahman Centre for Genome Research built from my personal donation and named after my father is located in the International Centre for Chemical and Biological Sciences (ICCBS) in Karachi and is emerging as a centre of excellence. It is equipped with the state-of-the-art gene sequencing facilities the best in the country and is now deeply involved in health and agricultural research under the able leadership of the dynamic director of the ICCBS, Prof Iqbal Choudhary.

The rapid advances in genome sequencing technologies are opening up a whole new era of medicine. We need to develop our own research base to develop new genetically engineered varieties of food crops rather than relying on seeds imported from the West. This will also reduce the danger of us becoming completely dependent on foreign masters. Control the food chain within a country and you can control that country. This must not be allowed to happen in Pakistan. We need to invest massively in developing salt-tolerant and drought-resistant varieties of different crops through natural selection or through genetic engineering before we are engulfed by the challenges of famine and drought that surely lie ahead. Science must come to the rescue.

Countries that are investing in such advances are earning billions of dollars. For Pakistan to emerge from the shackles of poverty, we need to invest in science, technology, innovation. We also need to establish strong linkages between research and industry/agriculture. But the development budget of the Ministry of Science and Technology in Pakistan (about Rs1.8 billion only) is extremely low. Our investment in education is also low a little over two percent of our GDP ranking us among the bottom nine countries of the world.

We must realise that in order to develop, we must invest in top quality schools, colleges and universities so that we can transition to a strong knowledge-based economy. It is time to change directions and invest in our real wealth our children so that we too can stand with dignity in the comity of nations.

The writer is chairman of UN ESCAP Committee on Science Technology & Innovation and former chairman of the HEC. Email: [emailprotected]

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Amazing genetics - The News International

Farmington Medical Startup Targets Hearing Loss With New Drugs – Hartford Courant

Researchers have established a startup business that could restore hearing that people have lost to construction, traffic, jet planes and even rock concerts.

Frequency Therapeutics, based in Farmington and Woburn, Mass., is developing drugs that would activate certain cells, stimulating the regrowth of hair cells in the inner ear to counter "chronic noise-induced hearing loss."

"The evolution of our hearing was not meant to hang out on subway platforms or put on earbuds or go to U2 concerts," said David Lucchino, chief executive officer of Frequency Therapeutics. "There's a disconnect between the evolution of hearing and the industrialized world we live in."

The company is part of the University of Connecticut's business incubation program, which aims to provide support to new business startups, and has received $32 million in financing. It is researching technology to develop a gel that would be injected in the middle ear between the eardrum and oval window in a doctor's office procedure of about 30 minutes.

The intent is to recreate sensory hair cells as many as 15,000 in each ear that act as antenna in converting sound into signals understood by the brain. Or as Lucchino says, how to "biologically hot-wire the inner ear" to help it regenerate itself.

The human ear is incapable of spontaneously restoring lost or damaged hair cells, making hearing loss permanent.

Jeff Karp, who co-founded Frequency Therapeutics in 2015, said "druggable tissue regeneration" has a broad platform, with hearing loss a first application.

Activating the body's progenitor cells known as descendants of stem cells that can form one or more kinds of cells in regenerating tissue also could be applied to treating skin disorders or reversing vision problems. By activating the progenitor cells, Frequency Therapeutics can prod disease modification without the complexity of genetic engineering.

Birds and amphibians, such as frogs, regenerate their hearing, which is critical for their survival. That observation prompted researchers to ask if the same can be done for humans, said Karp, an associate professor of medicine at Harvard Medical School's teaching affiliate, Brigham and Women's Hospital in Boston. "We knew the biology existed."

Lucchino said researchers looking to establish companies that will draw investment money consider ways to have the "biggest impact helping people." Finding a successful treatment for hearing loss would benefit a large market: About 36 million people in the U.S. are affected, researchers say.

The World Health Organization estimates that 1.1 billion young people are at risk for hearing loss from recreational noise. About 360 million people worldwide, or 5 percent of the global population, have disabling hearing loss. Of that, 32 million are children.

Hearing loss caused by prolonged exposure to excessive noise can be due to heavy construction or military training, but common loud noises like subways, concerts and the use of headphones can have a significant impact on hearing.

Genetic causes, complications at birth, certain infectious diseases, chronic ear infections, the use of particular drugs, exposure to excessive noise and aging also are blamed for hearing loss, according to the World Health Organization

The next step for Frequency Therapeutics is for researchers to move their work to the clinic, expected in the next year to 18 months, and "show this drug actually works," Lucchino said.

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Farmington Medical Startup Targets Hearing Loss With New Drugs - Hartford Courant

Scientists find new genetic locations for type 2 diabetes – Medical News Today

Scientists from University College London and Imperial College London in the United Kingdom have identified new genetic locations that might make some people more prone to developing type 2 diabetes.

Type 2 diabetes affects hundreds of millions of people worldwide, and the numbers have skyrocketed in recent years. According to the World Health Organization (WHO), the number of people with diabetes has almost quadrupled in the past few decades, from 108 million in 1980 to 422 million in 2014.

In the United States, 29 million people currently have diabetes, and 86 million are thought to have prediabetes.

Until now, researchers were aware of 76 chromosomal locations, or "loci," that underlie this metabolic disease. However, new research analyzed the human genome further and found an additional 111.

The new study - published in the American Journal of Human Genetics - was co-led by Dr. Nikolas Maniatis of University College London's (UCL) Genetics, Evolution, and Environment department, together with Dr. Toby Andrew of Imperial College London's Department of Genomics of Common Disease.

Using a UCL-developed method of genetic mapping, Maniatis and team examined large samples of European and African American people, summarizing 5,800 cases of type 2 diabetes and almost 9,700 healthy controls.

They found that the new loci - together with the ones previously identified - control the expression of more than 266 genes surrounding the genetic location of the disease.

Most of the newly discovered loci were found outside of the coding regions of these genes, but within so-called hotspots that change the expression of these genes in body fat.

Of the newly identified 111 loci, 93 (or 84 percent) were found in both European and African American population samples.

After identifying genetic loci, the next step was to use deep sequence analysis to try to determine the genetic mutations responsible for the disease.

Maniatis and colleagues used deep sequencing to further examine three of the cross-population loci with the aim of identifying the genetic mutations. They then investigated a different sample of 94 Europeans with type 2 diabetes, as well as 94 healthy controls.

The researches found that the three loci coincided with chromosomal regions that regulate gene expression, contain epigenetic markers, and present genetic mutations that have been suggested to cause type 2 diabetes.

Dr. Winston Lau, of UCL's Genetics, Evolution, and Environment department, explains the significance of these findings:

"Our results mean that we can now target the remaining loci on the genetic maps with deep sequencing to try and find the causal mutations within them. We are also very excited that most of the identified disease loci appear to confer risk of disease in diverse populations such as African Americans, implying our findings are likely to be universally applicable and not just confined to Europeans."

Dr. Maniatis also highlights the contribution their study brings to the research community:

"No disease with a genetic predisposition has been more intensely investigated than type 2 diabetes. We have proven the benefits of gene mapping to identify hundreds of locations where causal mutations might be across many populations, including African Americans. This provides a larger number of characterized loci for scientists to study and will allow us to build a more detailed picture of the genetic architecture of type 2 diabetes," says the lead author.

Dr. Andrew also adds, "Before we can conduct the functional studies required in order to better understand the molecular basis of this disease, we first need to identify as many plausible candidate loci as possible. Genetic maps are key to this task, by integrating the cross-platform genomic data in a biologically meaningful way."

Learn how gene discovery could yield new treatments for type 2 diabetes.

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Scientists find new genetic locations for type 2 diabetes - Medical News Today

With more light, chemistry speeds up — ScienceDaily – Science Daily


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With more light, chemistry speeds up -- ScienceDaily
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Light initiates many chemical reactions. Experiments have for the first time demonstrated that increasing the intensity of illumination some reactions can be ...
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