Rand Pauls audacious new sham: A phony religious epiphany

Evidently sensing that the Republican Party may be in some kind of crisis, Sen. Rand Paul, R-Ky., argued at a recent fundraiser that the GOP should embrace the tenets of his pet political philosophy, libertarianism. But Paul didnt just suggest a conversion from long-held Republican values to libertarian ones; rather he tried to make the case that libertarian values are already consonant with the moral systems that underpin many foundational Republican positions. One of his main rhetorical goals was, therefore, making Christianity and libertarianism seem compatible, to attract traditionally Christian GOP supporters to libertarian ideas.

Even leaving aside the bizarre gesture of pure convenience to Christianity, which seems to have been brought in here as a post-hoc rhetorical flourish to do little more than sweeten the libertarian pot, Paul didnt make a great case for the actual compatibility of Christianity and libertarianism.

Libertarian and liberty doesnt mean libertine, Paul claimed at the gala for the American Principles Project, referring to the tendency of libertarians to prefer government not intervene in various spheres of life, often including the realms of marriage, contraception and abortion. Paul was unclear as to whether he believes the state should have a role in the regulation of marriage and abortion, saying instead, rather cryptically, that Freedom needs tradition to give it its balance and its stability, its sense of family and community, but tradition needs freedom to invigorate it and give it spirit and excitement.

If what Paul intends to say here is that Christianity and libertarianism are amenable to one another because Christianity provides the moral compass libertarianism doesnt have that is, that one can protect marriage and defend against oft-objected to practices like abortion through the selective reference to Christian values by otherwise libertarian political agents the question is: Why would someone with such a commitment to Christianity ever commit themselves to a political philosophy without a similar commitment?

That libertarianism needs the moral framework of a separate philosophy imported into it to prevent it from becoming, as Paul put it, libertinism only indicates that libertarianism itself does not begin from the moral framework of Christianity. Instead, it requires that Christian ethics be tucked into it after the fact, if theres anywhere for them to fit. GOP Christians tempted by Pauls proselytizing should ask themselves this: If libertarianism arises out of a wholly separate ethical framework than Christianity, what authority underlies that framework, and why should they, Christians, respond to it? Moreover, why make oneself beholden to a philosophy that uses Christianity as a mere instrument to support itself morally, rather than one that responds to Christianity as its ultimate and final ethical authority?

When it came to the difficulties Paul had in making his Christo-libertarian case, this was only the tip of the iceberg. In arguing for his oft-cited policies of prison and sentencing reform, he said, As Christians who believe in forgiveness, noting that overly long sentences and penalties such as felon disenfranchisement violate that principle and harm those who deserve a second chance. Here, Paul seems right on the money: The reality for Christians is that the guiltiest are those most in need of mercy and forgiveness, and our current justice system promotes neither value, resulting in the unnecessary destruction of so many lives and communities.

Yet Pauls reasoning here doesnt stand up to the scrutiny of consistent application, which weakens his claim that libertarianism and Christianity are well-committed philosophies. Hes willing, for example, to have mercy on those guilty of crimes by reducing prison sentences, returning felons the right to vote, and doing away with mandatory minimum sentences. This all fits well with Christs call for service to the least of these outsiders, criminals, the poor, the hungry, the sick. But what does Paul imagine in terms of shaping the state to show mercy to people in those other categories? What provisions should the state make for, say, the sick and the poor?

In these arenas, Pauls interest in mercy and the justice of the Gospel seems to mysteriously dry up.

Consider his policy on the delivery of healthcare, as described to a group of University of Louisville medical students in 2013: I think we as physicians have an obligation. As Christians, we have an obligation I really believe that, and its a deep-held belief But I dont think you have a right to my labor. You dont have a right to anyone elses labor. Pauls gambit here was to define healthcare not as a right but as something altogether different and unenforceable. Of course, no one proposes any healthcare policy that would force doctors to labor, only those that would offer doctors money to work, a system under which they already presumably operate; in universal healthcare plans, the payment would just come from a different source than insurance companies or individuals. But Paul is clear: While physicians might have some kind of vague moral obligation to lend a hand to the poor, the state should not, in his view, legitimize that duty by expanding universal healthcare to all. Why the state should exemplify and extend Christian forgiveness and mercy to the criminal but not the ill is anyones guess.

The same curious hesitance toward outreach applies to Pauls policies on poverty. His solution for aiding the impoverished in America? Economic freedom zones, or areas targeted for tax decreases and other incentives to create jobs and generate wealth. Unfortunately for Paul, this hands-off approach to reducing poverty has been tried, tested and proven to fail, featuring no significant difference in economic growth or job creation inside the enterprise zones from the surrounding area.

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Rand Pauls audacious new sham: A phony religious epiphany

Libertarian enters mix for Pa. governor

Published: Thursday, Feb. 20, 2014, 12:33p.m. Updated 23 hours ago

HARRISBURG A Libertarian Party activist is the first third-party candidate to enter the Pennsylvania governor's race.

Ken Krawchuk, who ran unsuccessfully for governor in 1998 and 2002, said Thursday he'll seek the Libertarian Party's nomination at its convention this weekend in Bethlehem.

As a third-party candidate, Krawchuk must gather more than 16,000 voters' signatures between March 12 and Aug. 1 to be listed on the November ballot. Republican and Democratic candidates need only 2,000 signatures but must win their party's nominations in the May 20 primary in order to run in the general election.

Krawchuk, a 60-year-old information technology consultant from the Philadelphia suburb of Abington, advocates separating the roles of society and government. He favors smaller government and lower taxes and opposes laws that criminalize marijuana and outlaw same-sex marriage.

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Libertarian enters mix for Pa. governor

Cook Islands ratings affirmed at 'B+/B'

Standard & Poor's Ratings Services affirmed its 'B+/B' issuer credit ratings on the Cook Islands. The outlook is stable. The Transfer & Convertibility assessment remains 'AAA'.

"The ratings affirmation Islands reflects the Cook Islands' moderate average income level and modest government debt burden," Standard & Poor's credit analyst Craig Michaels said. "However, vulnerabilities associated with the country's weak policymaking culture and institutional settings constrain the ratings. Despite recent improvements, we believe the government can further strengthen institutional checks and balances in order to safeguard its past gains in fiscal consolidation."

In addition, the Cook Islands economy is vulnerable to the impact of cyclones and changing tourism preferences on its major revenue earner, the tourism industry. Further moderating the ratings are the country's lack of monetary policy flexibility and data deficiencies that constrain our analysis of the Cook Islands' external position.

We project Cook Islands' real per capita GDP growth to average 3.6% over 2014 to 2016, partly reflecting further expected declines in its population. Emigration is high in the Cook Islands, averaging 1.5% of the population annually during the past 17 years. Although the Cook Islands' integration with the Australian and especially New Zealand labor markets gives the Cook Islands a valuable alternative for its citizens, it does constrain prospects for the economy to diversify into higher value-added areas. However, we expect moderate further increases in tourist arrivals to support economic growth, with tourism remaining the primary economic activity in the Cook Islands. Income is high compared to that of peers, with GDP per capita estimated at US$21,000 in the year ended June 30, 2012.

In our base-case scenario, we project general government debt will rise by an average 3.3% of GDP annually over 2014 to 2016, with net debt expected to average 22% of GDP over the same period. General government interest expenditure to revenues is estimated to be a low 1.0% on average between fiscal years 2014 and 2016, reflecting the concessional and long-term nature of current borrowings. The Cook Islands' increasing debt is mainly because of water and sanitation investment, although ongoing shortfalls in infrastructure and basic services will continue to limit fiscal flexibility. And while government debt remains low, a large portion of this debt is exposed to foreign currency movements.

We equalize the local currency rating with the foreign currency rating, reflecting the Cook Islands' absence of both monetary policy flexibility and a domestic capital market, and its use of the New Zealand dollar. The transfer and convertibility assessment for the Cook Islands is 'AAA', which also reflects its use of the New Zealand dollar.

Mr. Michaels added: "The stable outlook balances the Cook Islands' sound economic growth prospects and low level of government debt, against the challenges it faces in overcoming weak political and institutional settings and infrastructure shortcomings."

We would lower the ratings if a weakening in global economic conditions reduces tourism sector receipts and, in turn, worsens the government's finances. A weakened commitment to uphold past fiscal gains through high operating spending, resulting in its debt burden rising by significantly more than we currently expect, could also bring pressure on the ratings.

Improvements in the sovereign creditworthiness could come with sustained gains in policymaking stability and effectiveness, evidenced by the reduction of sizable data deficiencies, and progress in increasing economic opportunities for residents.

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Cook Islands ratings affirmed at 'B+/B'

CHOP Researcher Co-Leads Study Finding Genes that Affect Blood Pressure

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Newswise Philadelphia, Feb. 20, 2014 A large international study analyzing genes in tens of thousands of individuals has discovered 11 new genetic signals associated with blood pressure levels. Ten of those signals are in or very near genes encoding proteins that appear to be likely targets for drugs already in existence or in development.

The fact that most of these new gene signals are druggable targets offers the possibility of expedited pharmaceutical development of therapeutics for high blood pressure, a serious risk factor for cardiovascular diseases, said geneticist Brendan J. Keating, D. Phil., of The Center for Applied Genomics at The Childrens Hospital of Philadelphia, co-senior author of the study. Some of the protein targets already are targets of existing drugs for other diseases, while others are the focus of drugs currently in early-phase clinical trials or under preclinical development.

Keating collaborated with two other senior co-authors, Folkert W. Asselbergs, M.D., Ph.D., of University Medical Center Utrecht, the Netherlands, and Patricia B. Munroe, Ph.D., of Queen Mary University, London, U.K. The study appears online today in the American Journal of Human Genetics. Study co-authors were from the U.S., the U.K., the Netherlands, Canada, Germany, Sweden and Ireland.

High blood pressure, or hypertension, a chronic medical condition, is a well-known risk factor for heart disease, stroke, peripheral artery disease and chronic kidney disease. It is a complex condition, affected by many different genes. Because not all patients respond well to current blood pressure medications and other treatments, and other patients require combinations of three or more drugs, there is a substantial unmet need for improved medicines.

In the current study, the researchers performed a discovery analysis of DNA from more than 87,000 individuals of European ancestry. They then assessed their initial findings in a replication test, using an independent set of another 68,000 individuals.

The study team confirmed 27 previously discovered gene signals associated with blood pressure, and discovered 11 novel genetic signals. When the researchers used pharmacological databases to analyze potential targets in the discovered genetic regions, they found that gene products associated with 10 of the genes were predicted to be targets for small-molecule drugs. Two genes, KCNJ11 and NQO1, in fact, are already currently targeted by existing approved drugs. If clinicians can reposition existing drugs to treat some patients with hypertension, this will save significant time in drug development, as they wont be starting development from scratch, said Keating.

Keating added that other gene signals discovered in the study are associated with candidate drugs currently under development within pharmaceutical companies, and it may be possible that they can be repositioned as blood pressure therapeutics.

He stressed that even with possible repositioning, much research remains to be done to determine which drug candidates are effective against hypertension, possibly in personalized treatments based on patients genetic makeup. Keating added that the list of genes affecting blood pressure will likely grow as research continues.

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CHOP Researcher Co-Leads Study Finding Genes that Affect Blood Pressure

Using Supercomputers To Speed Up Genome Analysis

February 20, 2014

Image Caption: Beagle, a Cray XE6 supercomputer at Argonne National Laboratory, supports computation, simulation and data analysis for the biomedical research community. Credit: Argonne National Laboratory

Lee Rannals for redOrbit.com Your Universe Online

Researchers writing in the journal Bioinformatics say that genome analysis can be radically accelerated.

Over the years, the cost of sequencing an entire human genome has dropped, but analyzing three billion base pairs of genetic information from a single genome can take months. A team from the University of Chicago is reporting that one of the worlds fastest supercomputers is able to analyze 240 full genomes in about two days.

This is a resource that can change patient management and, over time, add depth to our understanding of the genetic causes of risk and disease, study author Elizabeth McNally, the A. J. Carlson Professor of Medicine and Human Genetics and director of the Cardiovascular Genetics clinic at the University of Chicago Medicine, said in a statement.

Megan Puckelwartz, a graduate student in McNallys laboratory and the studys first author, said the Beagle supercomputer based at Argonne National Laboratory is able to process many genomes simultaneously rather than one at a time.

It converts whole genome sequencing, which has primarily been used as a research tool, into something that is immediately valuable for patient care, Puckelwartz said in a statement.

Scientists have been working on exome sequencing, which focuses on just two percent or less of the genome that codes for proteins. About 86 percent of disease-causing mutations are located in this coding region, but still about 15 percent of significant mutations come from the other coding regions.

Researchers used raw sequencing data from 61 human genomes and analyzed the data on Beagle. They used publicly available software packages and a quarter of the computers total capacity, finding that a supercomputer environment helped with accuracy and speed.

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Using Supercomputers To Speed Up Genome Analysis