DNA Genotek at ESHG 2013 - Dr. Calvin Harley, Ph.D. of Telomere Diagnostics presents at ESHG 2013
Calvin Harley, Ph.D., of Telomere Diagnostics shares his clinical research work into the impact of telemere length on health and aging at the 2013 European S...

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DNA Genotek at ESHG 2013 - Dr. Calvin Harley, Ph.D. of Telomere Diagnostics presents at ESHG 2013 - Video

Today in Science
I am Syra Mehdi, and my purpose is to provide you with the latest most interesting and fascinating research in the world of science. -Biotechnology, the comb...

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Today in Science - Video

By Dennis Thompson HealthDay Reporter

TUESDAY, Feb. 25, 2014 (HealthDay News) -- U.S. Food and Drug Administration hearings opened Tuesday on a controversial fertilization technique that uses the DNA from three people -- two women and one man -- with the goal of preventing inherited genetic diseases.

The technique involves the unfertilized eggs, or "oocytes," from two females. Parts of each egg are combined to weed out inherited genetic disorders contained in one woman's DNA, and the resulting healthy egg is then fertilized using a male's sperm.

The FDA's two-day hearing is meant to provide a forum for discussing how this technique might be tested in human clinical trials.

But the discussion is expected to veer into the ethics of manipulating human genetics to produce "perfect" babies.

"The potential benefits are huge, but the potential harms are also huge," said Dr. Michelle Huckaby Lewis, a faculty member at the Johns Hopkins Berman Institute of Bioethics and the Genetics and Public Policy Center, in Washington, D.C.

The procedure could have unintended health consequences both for newborns and for future generations, as the genetic tinkering reverberates through time, Lewis said.

In addition, she said, the technique raises troubling questions of parental rights and family structure.

"When you use a technology in a new way like this, it really challenges our notions of what it means to be a parent and what it means to be a family," Lewis said.

The hearing was prompted by the work of Shoukhrat Mitalipov, an associate scientist at Oregon Health & Science University (OHSU).

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FDA Explores '3-Person' Embryo Fertilization

Story Created: Feb 26, 2014 at 12:27 AM ECT

Story Updated: Feb 26, 2014 at 12:27 AM ECT

INFECTIONS In addition to HPV infections discussed last week, there are other infections that can increase the risk of cancers. Hepatitis B and C viruses increases the risks of liver cancers. Human T-Cell Leukemia Virus -(HTLV-1)-Increases the risk of leukemia and lymphoma. Human Immunodeficiency virus (HIV)-increases the risk of lymphoma, and a rare cancer called Kaposi Sarcoma. Epstein Barr Virus (E.B. virus) is linked to increased risk of lymphoma. Human Herpes Virus is a risk factor for Kaposi Sarcoma Helicobacter Pylori-a is bacteria that causes stomach ulcers and is thought to increase the risk of stomach cancers and lymphomas.

ALCOHOL There are clear patterns that have emerged between alcohol consumption and certain types of cancer such as head and neck cancers, oesophageal, liver, breast and colon cancers. People who consume 50 or more grammes of alcohol per day have a two or three times greater risk of developing cancer than non drinkers. When alcohol is metabolised, it forms a compound known as Acetaldehyde which is toxic and a possible human carcinogen which damages human DNA. Alcohol also generates reactive oxygen species which damages the DNA, in addition, alcohol impairs the bodys ability to break down and absorb a variety of nutrients that may be associated with cancer risks. Alcohol also increases blood levels of oestrogen, a sex hormone linked to risk of breast cancers.

FOODS AND CHEMICALS Chemicals can be found in certain foods such as potato chips, French fries and other food products which are produced by high temperature cooking. One example is Asparagine which is an amino acid, a building block of proteins found in many vegetables and foods, such as potatoes. When heated to high temperatures, Asparagine, can form Acrylamide -a possible human carcinogen which can cause oral, pharynx, larynx, breast and ovarian cancers. Heterocyclic amines (HCA) and Polycyclic aromatic hydrocarbons (PAH) have also been found to be cancer causing. These are produced when muscle meat, including beef, pork or poultry, is cooked at very high temperature. HCA and PAH can cause mutations or changes in DNA that may increase cancer risks. Artificial sweeteners: These are substances that are used instead of sucrose (table sugar) to sweeten food and beverages. They include; saccharin, aspartame, sucralose, neotame and cyclamate. Many of these chemicals are thought to be carcinogenic as they have been found to cause cancers in animal studies. Agricultural products: Researches have shown that people exposed to certain products may have an increased risk of developing one or more types of cancer. Farmers, farm workers and family members may be exposed to substances such as pesticides, herbicides, engine exhausts, solvents, dusts, animal viruses, fertilisers, fuels and certain microbes that may increase cancer risks. Chemicals such as Formaldehyde, a colorless, flammable, strong smelling chemical used in building materials and house hold products,is also carcinogenic especially in cases of long term exposures. It is used in pressed woods, particle boards, plywoods, fibre boards, glues and adhesives, and is also found in fungicides, germicides, disinfectants and in preservatives in mortuaries. People who have certain jobs like painters, construction workers and those in chemical industries have increased risk of certain cancers especially when exposed to chemicals such as Asbestos, benzene, cadmium, nickel and vinyl chloride.

RADIATION Ionising radiation can cause cell damage that leads to cancers. X rays medically used for diagnostic investigations can increase cancer risk, even though the risk is low. Radiation therapy used to treat certain cancers can also increase the risk of some other cancers. Its not uncommon to meet a patient who requests an X-ray even when it is not necessary. The fact is that x-rays are a diagnostic tool, not a treatment, and they are not always beneficial. Unnecessary demand and frequent exposure to them may not be a wise idea. Ultra Violet (UV) radiation from the sun is another risk factor. Our UV index is generally high each time you see the weather news. These rays cause the early aging of the skin and skin changes that can lead to skin cancers, especially in caucasians, albinos and people with low melanin (skin pigmentations).

HAIR DYES More than 5,000 different chemicals are used in hair dye products, some of which are reported to be carcinogenic. Over the years, some studies have found an increased risk of bladder cancers in hairdressers and barbers. Some studies also linked the personal use of hair dyes with increased risks of certain cancers of the blood and bone marrow. However some of these studies need further research to make definitive conclusions but given the widespread use of hair dye products, even a small increase in risk may have a considerable public health impact.

SMOKING The role of smoking in the development of many forms of cancers is well documented. Each cigarette consists of over 400 carcinogenic materials that causes DNA damage and increased cancer risks as well as other diseases.

AGEING Cancer risk increases as you grow older, with most cancers occuring in people during their fifties or sixties. However many other cancers do develop before then, and there are some forms of cancers that afflict children.

FAMILY HISTORY Certain cancers develop because of changes or mutations in genes and risk factors can trigger some of these changes. Several cases of the same cancer types in a family are linked to inherited gene changes. If you think you are at risk, talk to your doctor and get checked. Contact Dr Maxwell on 3631807/7575411.

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Tidal wave of cancers Part 2