Chemistry - Molecular Structure (1.5 of 45) Basic Shapes - Linear
Visit http://ilectureonline.com for more math and science lectures! In this video I will introduce the basic linear shapes of the molecular structure.
By: Michel van Biezen
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Chemistry - Molecular Structure (1.5 of 45) Basic Shapes - Linear - Video
The Newman Comets scored 22 points in each of the final three quarters Friday night in Amboy, downing the Clippers 81-52 in a Three Rivers North game.
The Comets (17-0, 5-0) led 15-12 after one quarter, then proceeded to outscore Amboy (2-13, 0-4) 66-40 the rest of the way. Newman shot almost 50 percent from the floor (28-for-57) and 40 percent from 3-point range (9-for-22), and forced 23 Clipper turnovers.
A.J. Sharp had 26 points, three assists and three steals, and Noah McCarty added 22 points and 12 rebounds for the Comets. Nate Terveer finished with 12 points and four steals, and Micah Trancoso dished five assists.
Ottawa 63, Sterling 50: The Golden Warriors led 37-34 at halftime, but were outscored 29-13 in the second half of a NIB-12 West loss at Kingman Gym.
Zach Rehmert had 15 points for Sterling (6-8, 2-2), and Joe Brouilette added eight points and four rebounds. John Carroll scored 17 points and grabbed 15 rebounds for the Pirates (14-1, 4-0), including their only 3-pointer.
Morrison 50, Erie 36: Bill Greul scored 16 points, and Kaleb Church had 10 points, as the Mustangs (8-11, 4-1 Three Rivers North) handled the Cardinals in Morrison.
Ken Cole led Erie (0-17, 0-5) with 11 points.
Bureau Valley 69, Riverdale 45: Tommy Johnston tossed in 22 points, and Parker Neuhalfen added 17 as the Storm (14-7, 5-0 Three Rivers North) routed the Rams in Manlius.
Jake Gellerstedt had 21 points for Riverdale (5-11, 1-4).
Prophetstown 61, Fulton 51, 2OT: Ethan Howard scored 24 points, and Grant Ames added 20 as the Prophets (4-10, 1-3 Three Rivers North) upset the Steamers in Prophetstown.
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January 17, 2014 - Major Indoor Soccer League (MISL) Missouri Comets INDEPENDENCE, Missouri - In front of 4,349 fans at the Independence Events Center, the Missouri Comets earn a victory over the Milwaukee Wave in the first half of the home-and-home series that is taking place this weekend. The Comets clicked all night both offensively and defensively, scoring a 22-4 victory. Aided by three long range three-point goals against Milwaukee's sixth attacker, the Comets never trailed and ran away with the victory in the fourth quarter. Lucas Rodriguez led all scorers with seven points for the night.
The first half was a strong one for the Comets. Rodriguez started off the night with a power play goal four minutes into the first quarter. Milwaukee's Ian Bennett would take credit for the Wave's only goal of the half, tapping a shot past Comets goalkeeper Danny Waltman's reach.
Leo Gibson, with the help of a Milwaukee defender, broke the tie shortly after that and Byron Alvarez tapped in a goal from the corner to end the quarter. Defender Brian Harris only needed fourteen seconds of the second quarter to blast home a three point goal and give the Comets a 9-2 lead they would take into the half.
Wary of a third quarter Wave comeback the Comets buckled down defensively. Expectedly, Coach Keith Tozer's squad came out very aggressively from the break. The Wave's Luan Oliveria would score the second, and ultimately final, goal for Milwaukee with five minutes to spare in the period. However, John Sosa worked a perfect restart pass to Lucas Rodriguez to answer.
The fourth quarter belonged to the Comets. Ramone Palmer would score midway through the period to increase the Comets lead to 13-4. Milwaukee then inserted the sixth attacker to try and climb back into the match. Fortunately for the Comets, Robert Palmer, Harris and Rodriguez each took advantage of an open net for three-point scores. Altogether, Missouri netted an eleven point final quarter and a 22-4 victory.
These same two teams square off tomorrow night in Milwaukee at 6:00pm CT. Fans can watch the match live on the Comets website, CometsIndoorSoccer.com/Live-Feed. Missouri returns home to the Independence Events Center next Friday, January 24th at 7:35pm CT to face the St. Louis Ambush in the team's annual Retro Game. For tickets or information call 855.4KC.GOAL.
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FULTON Starting with the Caston Shootout from earlier in the month, J.R. Howells Caston squad has been able to mend its early wounds from the comforts of home.
The Comets entered Friday nights game having won four of five games during the home stretch and were looking to continue the success against conference foe South Newton Friday.
Needless to say, the Rebels have had another rough start to their season, entering at 1-6 so far. In fact theyve gone just 3-68 going back to the 2010-2011 season.
In his second stint as head coach at South Newton, Michael Hall is trying to resurrect his once-found success, having led Rebel teams to 258 victories and three sectional titles.
Balanced scoring was the key Friday, as the Comets jumped on South Newton early. Caston scored 12 unanswered points to start the game and never looked back, finishing with a 55-38 victory.
Quentin Douglass got things started with a 3 followed by consecutive stickbacks by juniors Jake Kingery and Alex Howdeshell. The surge culminated with another 3 by freshman Eli Douglass. A Howdeshell jumper gave Caston a 16-4 lead, but Trever Lowe scored on a steal and layup as time expired to draw the Rebels to within 10 after one.
Junior Dustin Offenberger drilled a 3 to start the second, adding to his four first-quarter points. After a 5-0 run by South Newton junior Levi Hall, Caston proceeded to go on a 10-0 run to close out the half. Quentin Douglass and Offenberger scored on back-to-back three-point plays to give Caston a 29-13 lead at halftime.
Despite a recent slump from long-range, Offenberger has been a key part of Castons new inside threat.
Ive been trying to attack the rim more, he said. Coach Howell has been telling me to take it to the rim, and be strong with the ball.
The start of the third period saw the Rebels make their last stand and quite possibly gave them a glimpse of the future. Six-foot-5 sophomore Jarrett Hammell ignited South Newton by hitting a jumper from the wing followed by two more buckets to draw the deficit to nine with 4:22 to play. He led South Newton with 15 points in the game. Eli Douglass answered the brief run with a 3 followed by two baskets by Brayton Jellison.
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Newman's boys basketball team is facing a tall task, both literally and figuratively, on Saturday night.
The Comets (17-0) will venture out of conference play to tangle with Rockridge (16-0) in the marquee game of the Manny's Pizza Shootout. Tipoff is slated for 7 p.m., and is the last of seven games to be played that day at Mount Carroll Middle School.
The Rockets are the unanimous No. 1 team in the latest Associated Press Class 2A poll, while the Comets check in at No. 4.
"This will be a great measuring stick for us," Newman coach Ray Sharp said. "Sometimes we tend to get a little stagnant in practice, and having a game like this coming up is great motivation to keep improving. We have some lofty goals we want to accomplish, and if we are to do that, we'll see a team like Rockridge in the supersectional."
Sharp has scouted Rockridge three times this season, including Jan. 4 at the Galesburg Shootout. The Rockets knocked off Rockford East 63-60 that night.
"Their five starters are all really, really good," Sharp said. "They can all hurt you in a lot of ways."
Leading the way for the Rockets is 6-foot-8 senior center Ethan Happ, a Wisconsin recruit. He averages 31 points and 13 rebounds per game.
"He has the ball skills of a guard, but he can score down low," Sharp said. "When they feed the ball into him, we'll have to double down, and that's going to put a lot of pressure on our other players. We need to play great team defense."
Rockridge's second option is Brian Heath, a 6-4 junior wing who averages 23 points and eight boards a game.
"He's just so athletic," Sharp said. "He can dunk the ball any way you want it, but there's more to his game than that."
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Title: Practical Spirituality for Enriched Living: Author: Shri Nimishananda; Publisher: Satsangh Publications (Bangalore); Pages: 231; Price: Rs.225
Title: Chakras for Starters; Author: Savitri Simpson; Publisher: Anada Sangha Publications; Pages: 127; Prices: Rs.150
Both these easy-to-read books are for those who are on the spiritual path or want to embrace spirituality. In 46 chapters of two to three pages each, Shri Nimishananda dwells on ways to lead a balanced spiritual life in tune with nature. He writes on karmic debts, the spiritual code of conduct, and the inner enemies humans must guard against including lust, anger, attachment, greed, pride and jealousy. In what is by now globally accepted as truth, he underlines that meditation not only brings peace, contentment and happiness but also increases one's mental horizons. The book has simple tips on how meditation, prayers, watering plants and feeding birds and animals help us connect with divine energy. He insists that just 20 minutes of daily meditation can do wonders.
Savitri Simpson demystifies the 'chakras' - which form part of our spiritual anatomy and are the vortices of energy located along the central axis of our bodies. The book offers guided mediation and exercises for each chakra. Our sages have said that when the charkas are out of balance, they become the root cause for various diseases. Understanding and awakening the charkas can result in immense benefits including calmness, will power, inner peace, self control and, above all, spiritual transformation.
(M.R. Narayan Swamy is Executive Editor of IANS. He can be reached on narayan.swamy@ians.in)
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Let #39;s Play: Kerbal Space Program (career mode) 003: New Patch, New Challenges
I play KSP, the space simulator sandbox game by Squad. My personal goal for this series: To build a Kerbal space station!
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Let's Play: Kerbal Space Program (career mode) 003: New Patch, New Challenges - Video
How the Rosetta spacecraft will orbit a comet
How the Rosetta spacecraft will orbit a comet Asleep in the dark near Jupiter, a spacecraft is almost ready to make the first ever landing on a comet. Read m...
By: Jennifer Jones
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Space Science - The Future of Spaceflight K4600
To order a copy of this program visit http://www.tmwmedia.com/productlisting/details/space-science-the-future-of-spaceflight Space Science - The Future of Sp...
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Virgin Galactic's SpaceShipTwo space plane rockets through the stratosphere at 71,000 feet, its highest flight yet, during its third powered test flight on Jan. 10, 2014. The supersonic flight occurred over California's Mojave Air and Space Port. Virgin Galactic
A stunning new video lets viewers ride along on last-week's record-breaking test flight of Virgin Galactic's suborbital spaceliner SpaceShipTwo.
The newSpaceShipTwo rocket-powered test flight videodocuments the piloted vehicle's jaunt on Jan. 10, which set a company altitude record by reaching 71,000 feet (21,641 meters) in the skies aboveCalifornia'sMojave Air and Space Port.
SpaceShipTwoalso attained a top speed of Mach 1.4 1.4 times the speed of sound, which is roughly 761 mph (1,225 km/h) at sea level during the test, Virgin Galactic officials said.
The 2.5-minute video, which Virgin Galactic released earlier this week, captures highlights of theJan. 10 supersonic flight, beginning with a pre-dawn inspection of SpaceShipTwo on the tarmac. It then shows the spaceliner being lofted off the runway by its carrier aircraft, a behemoth known as WhiteKnightTwo.
WhiteKnightTwo is designed to drop SpaceShipTwo at an altitude of roughly 50,000 feet (15,240 m), at which point the spacecraft's rocket engine blasts into action. The video captures this dramatic moment from several different angles, incorporating footage shot from the ground and from cameras mounted on WhiteKnightTwo.
WhiteKnightTwo's cameras, in fact, show SpaceShipTwo dropping toward the parched desert below before the craft's engine kicks on, shooting a tail of flame behind the spaceliner and sending it streaking past and above its carrier plane.
Virgin Galactic remains on pace to launch its first customers to suborbital space sometime this year, company officials say. Tickets to ride the spaceliner cost $250,000, and more than 600 people have put deposits down to reserve a seat so far, including major celebrities like Ashton Kutcher and Justin Bieber.
A ride aboard SpaceShipTwo will let passengers experience a few minutes of weightlessness and afford them a view of Earth against the blackness of space.
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See Virgin Galactic's SpaceShipTwo space plane go supersonic
NASA Administrator Charles Bolden visited NASA's Glenn Research Center in Cleveland Jan. 17 to view progress on the advanced space propulsion technologies the center is developing to carry cargo and American astronauts further into space than ever before.
"The work going on here at Glenn is an essential part of NASA's Asteroid Redirect Mission, and by investing in this technology NASA is addressing risks that the nation's aerospace industries cannot," Bolden said. "This is a great example of a win-win for both NASA and the nation's technical capability."
Glenn Center Director Jim Free guided Bolden, U.S. Senator Sherrod Brown and U.S. Rep. Marcia Kaptur, both of Ohio, on a tour of Glenn's Electric Propulsion Laboratory, which houses a large space environment simulation chamber. The chamber is being enhanced for future testing of solar electric propulsion technologies, including those supporting NASA's proposed asteroid initiative, which involves identifying, capturing and relocating an asteroid for astronauts to explore.
"The advanced space propulsion technologies that will one day help humans land safely on an asteroid are just some of the remarkable discoveries being made at Glenn," Kaptur said. "It is my hope that this visit will give Mr. Bolden more data about the importance of Glenn's role in future missions and the agency's direction."
Solar Electric Propulsion (SEP) serves two critical functions: it provides the low thrust, long duration "push" needed to deflect an asteroid, coupled with the versatility of changing a spacecraft's trajectory after launch. SEP also is a critical technology that can be scaled up to cost effectively send cargo and astronauts to Mars.
"The agency's asteroid initiative represents an unprecedented technological challenge that will lead to new scientific discoveries and technological capabilities that will help protect our home planet and achieve the goal of sending humans to an asteroid by 2025," Bolden added. "And NASA's path to capturing and exploring an asteroid runs through Glenn Research Center."
Later this year, NASA and its commercial partners will mark another milestone in industry partnerships when it tests at Glenn the large solar array system to demonstrate the structural integrity of large array designs that one day will support advanced SEP.
"Glenn Research Center is an important reason why NASA is a global leader in advanced technology," Brown added. "Ohio has a proud history of innovation and NASA Glenn's asteroid and de-icing work continue that tradition. Not only does this research and technology make the world safer, it advances what mankind is capable of achieving."
For more information on the agency's asteroid initiative, visit:
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NASA Administrator Surveys Agency's Work in Advanced Propulsion Technologies
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January 17, 2014 02:38 PM ET
Computerworld - NASA is looking for help creating a new robotic rover that will deliver cargo to the surface of the moon.
In an effort to advance technologies needed to get astronauts to an asteroid or Mars , NASA wants to get back to the moon. The space agency needs robotic technology to help them get there.
The robotic machine NASA wants to build must be able to ferry cargo weighing 66 pounds to 1,102 pounds to various lunar sites.
The space agency is seeking proposals from the private sector and plans to create a partnership to build robotic a lunar lander..
The program is dubbed Lunar CATALYST, for Lunar Cargo Transportation and Landing by Soft Touchdown.
"As NASA pursues an ambitious plan for humans to explore an asteroid and Mars, U.S. industry will create opportunities for NASA to advance new technologies on the moon," said Greg Williams, NASA's deputy associate administrator for the Human Exploration and Operations Mission Directorate. "[This] will help us advance our goals to reach farther destinations."
NASA noted that, in a partnership, the agency would be able to contribute the technical expertise of NASA staff, access to NASA center test facilities, equipment loans, and software for lander development and testing.
NASA will host a pre-proposal teleconference on Jan. 27 to giving companies a chance to ask questions about the program.
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The Google lab known for working on unusual projects like self-driving cars is crafting a contact lens that could help diabetics manage blood sugar levels.
"We're now testing a smart contact lens that's built to measure glucose levels in tears," project co-founders Brian Otis and Babak Parviz said Thursday in a blog post.
The lens works "using a tiny wireless chip and miniaturized glucose sensor that are embedded between two layers of soft contact lens material," Otis and Parviz said.
They said prototypes have undergone clinical tests and talks were underway with the US Food and Drug Administration. The project was described as being in its early days, and partners were being sought to make the lenses marketplace reality.
"As you can imagine, tears are hard to collect and study," the Google X lab team members said.
"We wondered if miniaturized electronics -- think chips and sensors so small they look like bits of glitter, and an antenna thinner than a human hair -- might be the way to crack the mystery of tear glucose and measure it with greater accuracy."
Prototype lenses being tested at Google X can generate glucose readings about once a second. Researchers are looking into integrating tiny lights that would warn when blood sugar levels go above or below threshold levels, according to the blog post.
"We've always said that we'd seek out projects that seem a bit speculative or strange," Otis and Parviz said. "At a time when the International Diabetes Federation is declaring that the world is 'losing the battle' against diabetes, we thought this project was worth a shot."
Google cited figures indicating that diabetes affects one in every 19 people on the planet.
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Tata Motors launches Nano Twist at Rs 2.36 lakh
Tata Motors announced the launch of the new Nano Twist, a new addition to the Nano range. The new Nano Twist, will now allow hassle-free and relaxed driving in city traffic with the new first-in-class Electric Power Assisted Steering (EPAS) system, designed for easy manoeuvring in tight driving and parking situations. A new signature Damson Purple colour, with chrome accents, new sporty interiors with new fabrics and stunning in-car features, make the Nano Twist an exciting car to drive.
Unveiling the Nano Twist - Ranjit Yadav, President, Passenger Vehicle Business Unit, Tata Motors, said, Since its inception, the Nano has been a path-breaking invention and has been constantly developed to provide class-leading value, with our core philosophy of anticipating customers needs. Blending best-in-class technology and design engineering, we at Tata Motors have worked closely with our partners to take Awesomeness to a whole new level with the Nano Twist. The Nano Twist will redefine customers driving experience in city traffic with the EPAS. It comes loaded with trendy features, exciting new colour and sporty interiors, which makes it a cool, smart city car to hang-out with. We at Tata Motors will continuously innovate on the Nano platform, catering to the dynamic desires of our growing customer base of young, trendy urbanites.
Tata Motors Group global wholesales at 79,220 in December 2013
The Tata Motors Group global wholesales in December 2013, including Jaguar Land Rover, were 79,220 nos. Cumulative wholesales for the fiscal were 753,949 nos.
Global wholesales of all Tata Motors' commercial vehicles and Tata Daewoo range -- were 29,499 nos. Cumulative commercial vehicles wholesales for the fiscal were 335,926 nos.
Global wholesales of all passenger vehicles in December 2013 were 49,721 nos. Cumulative passenger vehicles wholesales for the fiscal were 418,023 nos.
Global wholesales of Tata Motors' passenger vehicles in December 2013 were 9,477 nos. Cumulative wholesales for the fiscal were109,115 nos.
Global wholesales for Jaguar Land Rover for the month were 40,244 vehicles. Jaguar wholesales for the month were 6,613 vehicles and cumulative wholesales were 57,783 vehicles, while Land Rover wholesales for the month were 33,631 vehicles and cumulative wholesales were 251,125 vehicles. Cumulative wholesales for Jaguar Land Rover for the fiscal were 308,908 vehicles.
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A meet convened by the district administration to redress farmers grievances at the Collectorate here on Friday had an unexpected visitor as T. Anitha Sironmani, Chairperson of the School of Biotechnology of Madurai Kamaraj University walked in and offered to assist the farmers with innovations achieved through nanotechnology.
Ms. Sironmani told the farmers that just one litre of nano solution, available with the Genetic Engineering Department of the university, could purify about 30,000 to 40,000 litres of dirty water. The purified water could be used for irrigation, fish culture and a host of other activities.
Each litre of the nano solution costs Rs. 200, she added.
She also said that herbal preparations of her department were capable of curing foot and mouth disease as well as rabies.
Just one dose of the preparation to be consumed orally in the form of a soup could cure the diseases in no time without any side effects. We have tried it out on animals as well as humans and they recovered completely, she said.
Collector L. Subramanian introduced her to the gathering as an expert in nano technology and urged them to make use of the innovations. Later, Ms. Sironmani said that people interested in trying out the innovations could contact her by dialling 9942146141.
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Scientists have developed a special DNA clamp to act as a diagnostic nano machine. It's capable of detecting genetic mutations responsible for causing cancers, hemophilia, sickle cell anemia and other diseases, more efficiently than existing techniques. Not only can the clamp be used to develop more advanced screening tests, but it could also help create more efficient DNA-based nano machines for targeted drug delivery.
To catch diseases at their earliest stages, researchers have begun looking into creating quick screening tests for specific genetic mutations that pose the greatest risk of developing into life-threatening illnesses. When the nucleotide sequence that makes up a DNA strand is altered, it is understood to be a mutation; specific types of cancers are understood to be caused by certain mutations. Even if one single nucelotide base has been inserted, deleted or changed, it can change the entire DNA sequence scientists call this a single point mutation.
To detect this type of mutation and others, researchers typically use molecular beacons or probes, which are DNA sequences that become fluorescent on detecting mutations in DNA strands. The team of international researchers that developed the DNA clamp state that their diagnostic nano machine allows them to more accurately differentiate between mutant and non-mutant DNA.
"Our DNA clamp probes can perform very similar applications compared to molecular beacons, which are being used in many diagnostic clinics around the world since they enable the rapid, fluorescent detection of specific DNA sequences, or mutations," Alexis Valle-Blisle, a Chemistry Professor at the Universit de Montral, Canada tells Gizmag."However, since they bind DNA using a clamp mechanism, i.e. a single DNA sequence from a patient is recognized by two DNA sequences on our clamp, they are now able to detect single point mutations with much more efficiency than molecular beacons do."
According to the team, the DNA clamp is designed to recognize complementary DNA target sequences like a clamp-switch. As soon as it recognizes them, it binds with them to form a stable triple helix structure, while fluorescing at the same time. Being able to identify single point mutations more easily this way is expected to help doctors identify different types of cancer risks, with greater sensitivity, accuracy and precision, and to inform patients about the specific cancers they are likely to develop. Diagnosing cancer at a genetic level could potentially help arrest the disease, before it even develops properly.
"Cancer is a very complex disease that is caused by many factors," explains Valle-Blisle. "However, most of these factors are written in DNA. We only envisage identifying the cancers or potential of cancer. As our understanding of the effect of mutations in various cancer will progress, early diagnosis of many forms of cancer will become more and more possible."
Currently the team has only tested the probe on artificial DNA, and plans are in the works to undertake testing on human samples. The team believes that the DNA clamp will "provide a new weapon in the toolbox of nano engineers, to help them to design more efficient and versatile DNA nano machines." For instance, to deliver drugs to only the tumor cells, and not healthy cells, scientists can make use of DNA-based nano machines, that are created by assembling many different small DNA sequences together to create a 3D structure, kind of like a box. When it encounters a disease marker, the box opens up and delivers the drug, enabling smart drug delivery. The DNA clamps are expected to help this whole process function better.
"The clamp switches that we have designed and optimized can recognize a DNA sequence with high precision and high affinity," Professor Francesco Ricci, at the University of Rome,Tor Vergata, Italy, tells us."This means that our clamp switches can be used, for example, as super-glue to assemble these nano machines and create a better and more precise 3D structure that can, for example, open in the presence of a disease marker and release a drug."
The international research project was funded by the US National Institutes of Health, the Italian Ministry of Universities and Research (MIUR), the Natural Sciences and Engineering Research Council of Canada, the Bill & Melinda Gates Foundation Grand Challenges Explorations program and the European Commission Marie Curie Actions program. Their paper describing the development was recently published in the journal ACS Nano.
Source: Universit de Montral
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Newswise ROLLA, Mo. Advanced manufacturing and advanced materials for sustainable infrastructure are the first of four best-in-class or signature areas Missouri University of Science and Technology intends to focus on in the coming years.
The two areas were chosen from among 15 proposals submitted by Missouri S&T faculty. The proposals and subsequent presentations were screened by a committee of faculty representatives from all academic areas on campus, then selected by S&T Chancellor Cheryl B. Schrader and Provost Warren K. Wray. The proposals were judged on how well they connected to long-term critical national issues, research and entrepreneurship potential, and alignment with Missouri S&Ts strategic plan.
From the beginning, we have known that to successfully implement our strategic plan, we would have to focus on signature areas of excellence, Schrader says. Our plan isnt about being everything to everyone. It is about deciding where it makes the most sense to invest, enable and grow, and providing the best return on that investment to our customers. These two areas represent a bold step in the future vitality of this university and will offer research and educational solutions to benefit Missouri, the nation and the world.
Attaining signature status in these areas means that Missouri S&T will build on their distinctive strengths in teaching and research to make the areas among the nations best, Schrader says. To better position S&T to achieve this status, last September Schrader announced new funding from campus and the University of Missouri System to support the hiring of additional faculty in signature areas, as well as in other areas of strategic importance. In all, S&T plans to add 100 new faculty positions by 2020, an increase of nearly 20 percent.
In the signature area of advanced manufacturing, S&T will emphasize instruction and research in the emerging fields of additive manufacturing; energy manufacturing; micro- and nano-scale manufacturing; network-centric and cloud manufacturing; advanced materials for manufacturing; and intelligent, sensor-enabled manufacturing.
The area will be led by a multidisciplinary team of researchers. That team includes Dr. Ming Leu, the Keith and Pat Bailey Missouri Distinguished Professor of Integrated Product Manufacturing; Dr. Wayne Huebner, professor and chair of materials science and engineering; Dr. Jag Sarangapani, the William A. Rutledge-Emerson Electric Co. Distinguished Professor of Electrical and Computer Engineering; Dr. Suzanna Long, assistant professor of engineering management and systems engineering; Dr. Frank Liu, professor of computer science; Dr. Greg Hilmas, Curators Professor of ceramic engineering; and Dr. Frank Liou, the Michael and Joyce Bytnar Professor of Product Innovation and Creativity.
This is a perfect fit for Missouri S&T because of the national importance of advanced manufacturing, the existing S&T strength in this area and our confidence in developing it to be among the best in the nation, Leu says.
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Missouri S&T Names 'Signature' Areas of Manufacturing, Infrastructure
-- Research findings enable disease molecular sub-typing to lead to more informed clinical decision-making
IRVING, Texas, Jan. 18, 2014 /PRNewswire/ --Caris Life Sciences, a leading biosciences company focused on fulfilling the promise of personalized medicine, will present a large international tumor profiling study of colorectal cancer (CRC) at the 2014 Gastrointestinal Cancers Symposium this week in San Francisco, Calif. With more than 7,000 patients comprehensively profiled by Caris Molecular Intelligence, this study represents the largest, multi-national analysis in a single laboratory setting of the main molecular anomalies in colorectal cancer. Colorectal cancer is the third most common cancer worldwide, with metastatic disease accounting for 40 to 50 percent of newly diagnosed patients.
"This comprehensive analysis of more than 7,000 patient cases illustrates that treatment of this cancer as one single disease is a flawed approach. The variety of mutations identified also point the way to new combinations of therapies and protein targets that can help direct future treatments," said Fadi Braiteh, M.D. and co-author on the study. "We are definitely moving from treating colon cancer as one disease to treating it as 20 to 30 different diseases. This research also highlights the feasibility of tumor profiling for colorectal cancer in the community setting, as well as establishes a high bar for standard of care for these patients."
This colorectal cancer study evaluated protein and DNA alterations in the EGFR pathway, including analysis of KRAS, NRAS, HRAS, BRAF, PIK3CA, ERBB4 and HER2 mutations/amplifications, as well as PTEN loss of expression and mutation in KRAS wild-type colorectal cancer patients. This dataset highlights the importance of the EGFR pathway in treating this disease by identifying a high frequency of specific and co-incident pathway alterations that have therapeutic implications.
"EGFR targeting therapies, cetuximab and panitumumab, are effective treatment for KRAS wild type CRC. Although mutations in KRAS predict resistance to EGFR Mab therapy, only 80 percent of CRC patients with KRAS wild type status respond to treatment," said Gargi Basu, Ph.D., from Caris Life Sciences and presenting author. "Testing for additional molecular alterations utilizing a multi-platform approach is critical to identifying those patients that are not likely to respond to anti-EGFR therapy alone and may respond better to a combination of targeted agents."
About Caris Molecular Intelligence
Caris Molecular Intelligence has been the leading cancer profiling service on the market since 2006, having been used for more than 60,000 cancer patients and counting by more than 6,000 oncologists in at least 59 countries to help develop individualized and actionable treatment plans that seek to improve patient care. Caris Molecular Intelligence utilizes the most comprehensive range of analytical technologies endorsed by the latest and most robust evidence immunohistochemistries, fluorescence and chromogenic in situ hybridization, polymerase chain reaction and Next-Generation sequencing to provide oncologists the most complete and clinically relevant profile of a patient's unique cancer-related biomarkers. Unlike other commercially available tumor profiling services, Caris Molecular Intelligence more completely interrogates a patient's unique tumor biology by going beyond just DNA analysis. Caris' service assesses additional important biological components like RNA and protein expression levels to establish a multi-dimensional profile of a patient's tumor that reveals more fully the complex biological processes that are driving that patient's cancer and, therefore, more, relevant targets for potential clinical action.
With a multi-dimensional profile of a patient's unique tumor, Caris Molecular Intelligence integrates insights from its proprietary and industry-leading evidence curation and bioinformatics platform to identify and report the most clinically relevant associations to drug therapies that are approved by the U.S. Food & Drug Administration or are in active clinical trials in the U.S. Managed by the Caris Evidence Design Board, a dedicated team of oncology experts that includes 5 Ph.D.s and 6 M.D.s, the Caris Molecular Intelligence evidence and bioinformatics platform curates, classifies and catalogues the findings and evidence from all relevant clinical studies in cancer and cancer biology available in the published scientific and medical literature, using a methodology adapted from the evidence review process of U.S. Preventive Services Task Force (www.uspreventiveservicestaskforce.org) of the Agency for Health Research and Quality (www.ahrq.gov). This platform incorporates the review of more than 100,000 publications and counting. Relying on the most robust evidence that meets Caris' quality standards, the Caris Molecular Intelligence evidence and bioinformatics platform can currently provide therapeutic guidance for up to 43 drug associations with Caris' multi-dimensional approach to tumor profiling, far exceeding the 12 that can be identified using next-generation sequencing alone. The Caris Molecular Intelligence bioinformatics platform electronically delivers the profile and all of these results in an easy-to-use report format that gives oncologists access to underlying evidence, enabling them to develop tailored treatment plans for each unique patient. For more information on Caris Molecular Intelligence, visit http://www.carismolecularintelligence.com.
About Caris Life Sciences
Caris Life Sciences is a leading biosciences company focused on fulfilling the promise of personalized medicine. As the first commercial mover in comprehensive molecular profiling in oncology, Caris Molecular Intelligence is an industry vanguard, with 60,000-plus patients profiled and counting. Ordered by nearly 6,000 oncologists in 59 countries, Molecular Intelligence correlates molecular data generated from a patient's tumor with biomarker/drug associations derived from clinical cancer literature. Using a variety of advanced and clinically-relevant technologies, Caris provides oncologists with the most clinically actionable information to help them personalize treatment for cancer patients. This multi-technology approach enables Caris to provide therapeutic guidance for 43 drug associations, compared to the 12 that can be found through use of next-generation sequencing alone. The company is also developing a series of blood tests based on its proprietary Carisome platform a revolutionary blood-based testing technology for diagnosis, prognosis, and theranosis of cancer and other complex diseases. Headquartered in Irving, Texas, Caris Life Sciences offers services throughout the U.S., Europe, Australia and other international markets. To learn more, please visit http://www.carislifesciences.com.
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