Monthly Archives: January 2013

UCP1 Extends Longevity Via Hormesis?

Posted on by

Uncoupling proteins affect mitochondrial function, altering the balance of energy going to heat versus building ATP molecules to store it for use elsewhere. Like a range of other mitochondrial manipulations, altering levels of uncoupling proteins can extend life in laboratory animals, and here researchers suggest this works via hormesis, causing just enough damage to spur repair mechanisms to greater ongoing effects for a net overall gain:

Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria considerably increases lifespan in high fat diet fed UCP1 transgenic (TG) mice in comparison to wildtype (WT).

In order to clarify the underlying mechanisms we investigated substrate metabolism as well as oxidative stress damage and antioxidant defense in SM of low fat and high fat fed mice. TG mice [showed] elevated lipid peroxidative protein modifications with no changes in glycoxidation or direct protein oxidation. This was paralleled by an induction of catalase and superoxide dismutase activity, an increased redox signaling (MAPK signaling pathway), and increased expression of stress protective heat shock protein 25.

We conclude that increased skeletal muscle mitochondrial uncoupling in vivo does not reduce the oxidative stress status in the muscle cell. Moreover it increases lipid metabolism and reactive lipid-derived carbonyls. This stress induction in turn increases the endogenous antioxidant defense system and redox signaling. All together our data argue for an adaptive role of reactive species as essential signaling molecules for health and longevity.

Link: http://www.ncbi.nlm.nih.gov/pubmed/23277187

Source:
http://www.fightaging.org/archives/2013/01/ucp1-extends-longevity-via-hormesis.php

Why Not Infuse a Person With Many, Many, Many Immune Cells?

Posted on by

One of the many things that can be accomplished today, but largely isn't due to regulation, is infusion of a large number of immune cells grown from a patient's own cells. Existing immune cells - or even skin cells - can be reprogrammed to form induced pluripotent stem cells, which can then be then expanded in number and redifferentiated into the hunter killer cells that rove the body in search of things to destroy.

So why not look ahead to a range of treatments that involve temporarily endowing a person with twice as many immune cells as he or she normally possesses? Or five times as many, or ten times as many, or more? There may well be a why not, at least one that lies beyond the concern shared with all stem cell treatments, which is controlling these cells well enough to avoid the risk of pluripotent cells slipping through and generating some form of cancer. That why not hasn't surfaced yet, however, and the fastest way to see whether or not it exists is more research, more clinical trials, and more responsible medical tourism.

The potential benefits are enormous, and much of the caution forced upon research and development in the US and Europe is both unnecessary and in place for reasons that have little to do with ensuring good outcomes.

In any case, researchers here demonstrate some of the basic methodologies needed to give someone a temporarily superhuman immune system:

Stem Cell Technology Could Help Harness Patients' Own Immune Cells to Fight Disease

The techniques the groups employed involved using known factors to revert mature immune T cells into induced pluripotent stem cells (iPSCs), which can differentiate into virtually any of the body's different cell types. The researchers then expanded these iPSCs and later coaxed them to redifferentiate back into T cells. Importantly, the newly made T cells were "rejuvenated" with increased growth potential and lifespan, while retaining their original ability to target cancer and HIV-infected cells. These findings suggest that manipulating T cells using iPSC techniques could be useful for future development of more effective immune therapies.

In one study, investigators used T cells from an HIV-infected patient. The redifferentiated cells they generated had an unlimited lifespan and contained long telomeres, or caps, on the ends of their chromosomes, which protect cells from aging. This is significant because normal aging of T cells limits their expansion, making them inefficient as therapies. "The system we established provides 'young and active' T cells for adoptive immunotherapy against viral infection or cancers."

It is worth noting that this isn't the first time researchers have shown that reprogramming cells to become pluripotent and then recreating their original lineage from those pluripotent cells has the effect of rejuvenating aspects of their biology. You might recall that researchers demonstrated mitochondrial rejuvenation via this methodology a few years back.

Source:
http://www.fightaging.org/archives/2013/01/why-not-infuse-a-person-with-many-many-many-immune-cells.php

TFP5 Shows Promise for Treating Alzheimer’s Disease

Posted on by

A new candidate for building an Alzheimer's therapy shows promise in mice:

When a molecule called TFP5 is injected into mice with disease that is the equivalent of human Alzheimer's, symptoms are reversed and memory is restored - without obvious toxic side effects. "We hope that clinical trial studies in AD patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment. Therefore, we suggest that TFP5 should be an effective therapeutic compound."

To make this discovery, [researchers] used mice with a disease considered the equivalent of Alzheimer's. One set of these mice were injected with the small molecule TFP5, while the other was injected with saline as placebo. The mice, after a series of intraperitoneal injections of TFP5, displayed a substantial reduction in the various disease symptoms along with restoration of memory loss. In addition, the mice receiving TFP5 injections experienced no weight loss, neurological stress (anxiety) or signs of toxicity. The disease in the placebo mice, however, progressed normally as expected. TFP5 was derived from the regulator of a key brain enzyme, called Cdk5. The over activation of Cdk5 is implicated in the formation of plaques and tangles, the major hallmark of Alzheimer's disease.

Link: http://www.eurekalert.org/pub_releases/2013-01/foas-pcr010213.php

Source:
http://www.fightaging.org/archives/2013/01/tfp5-shows-promise-for-treating-alzheimers-disease.php

TFP5 Shows Promise for Treating Alzheimer's Disease

Posted on by

A new candidate for building an Alzheimer's therapy shows promise in mice:

When a molecule called TFP5 is injected into mice with disease that is the equivalent of human Alzheimer's, symptoms are reversed and memory is restored - without obvious toxic side effects. "We hope that clinical trial studies in AD patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment. Therefore, we suggest that TFP5 should be an effective therapeutic compound."

To make this discovery, [researchers] used mice with a disease considered the equivalent of Alzheimer's. One set of these mice were injected with the small molecule TFP5, while the other was injected with saline as placebo. The mice, after a series of intraperitoneal injections of TFP5, displayed a substantial reduction in the various disease symptoms along with restoration of memory loss. In addition, the mice receiving TFP5 injections experienced no weight loss, neurological stress (anxiety) or signs of toxicity. The disease in the placebo mice, however, progressed normally as expected. TFP5 was derived from the regulator of a key brain enzyme, called Cdk5. The over activation of Cdk5 is implicated in the formation of plaques and tangles, the major hallmark of Alzheimer's disease.

Link: http://www.eurekalert.org/pub_releases/2013-01/foas-pcr010213.php

Source:
http://www.fightaging.org/archives/2013/01/tfp5-shows-promise-for-treating-alzheimers-disease.php

Cell Therapy Blog welcomes 2013

Posted on by

Happy new year to all our readers.  We look forward to our interactions throughout 2013. This month watch for:
We look forward to seeing you on the 2013 conference circuit.  For a complete and current list of 2013 cell therapy industry conferences, click here.

We will be in San Francisco next week during EBD Biotech Showcase and JP Morgan as well as at the Phacilitate Cell and Gene Therapy Forum in Washington, DC at the end of the month.

As always we welcome your comments, feedback, criticisms, and questions.

Thank you for all for everything to contributed to and did to support this blog and our efforts this past year.  Let's have a great 2013!


p.s.  Don't forget to follow Cell Therapy Blog on Twitter @celltherapyblog 

Source:
http://feedproxy.google.com/~r/CellTherapyBlog/~3/ABphTtPOrwo/cell-therapy-blog-welcomes-2013.html

Summer Undergraduate Research Fellowships in Molecular & Integrative Physiology

Posted on by

The Department of Molecular & Integrative Physiology at the University of Michigan offers summer fellowship programs to support undergraduate students that are interested in research in physiology and/or biomedical sciences. Any student who is currently enrolled at any degree granting University or College is invited to apply, with preference given to those students interested in a career in research. In general: 1) Biological science students will join our traditional Summer Undergraduate Research Fellowship (SURF) 2) Students from quantitative science majors (e.g. engineering, math, computer science) will join our Short Term Educational Program (STEP) towards Digestive and Metabolic Physiology 3) Underrepresented groups and those from economically disadvantaged backgrounds will join out Summer Undergraduate Research In Physiology (SURP) program. Each student will be matched, based on his or her interests, to a laboratory that is led by a faculty member of the Department of Molecular & Integrative Physiology or of the University of Michigan Medical School. The selected laboratories are involved in nationally recognized research, in topics such as hormones and signal transduction, obesity and diabetes, reproduction and circadian rhythms including sleep, gastrointestinal physiology including digestive diseases, and many aspects of cardiovascular disease. There will be a research forum at the end of the summer in which fellows will present their work, as well as opportunities to attend research seminars throughout the summer. Further details and application materials are available from the fellowship website: https://www.physiology.med.umich.edu/programs/undergraduate/undergradsindex.html The deadline for applications is February 1, 2013.

Source:
http://physiologynews.blogspot.com/2013/01/summer-undergraduate-research.html

Are you interested in the health sciences? Want to travel to Italy this summer?

Posted on by

Dr. Donato Romagnolo, Professor in Nutritional Sciences, will be leading a new program on Mediterranean Diet and Health that will be offered part in Tucson (1 week) and part in Verona (Italy, 3 weeks) in Summer 2013. The program will be offered through UA’s Study Abroad Office and has been approved to grant students 6 credits (NSC455SA). Students will learn about the biology, molecular biology and biochemistry of Mediterranean foods and diet and impact in the prevention and treatment of chronic diseases. There is also an opportunity to gain hands-on experience in food preparation with the help of Italian instructors. If of interest, the syllabus can be adapted to offer a writing emphasis option through additional assignments. Students will need to get approval of major advisors to gain credit hours from this class. Students must meet the following requirements in order to be eligible for this experience: • 2.75 minimum GPA • Completed NSC 170C1 (formerly NATS 104), NSC 101, or have an equivalent background in health, biological, or biomedical sciences • Junior or senior standing If interested, please refer to the attached brochure or to this website for more information: http://global.arizona.edu/study-abroad/program/mediterranean-diet-and-health. Questions? Please contact Dr. Donato Romagnolo, Professor of Nutritional Sciences and Cancer Biology (donato@email.arizona.edu), or Kendra Corey in the Office of Study Abroad (kcorey@email.arizona.edu) if you have any questions or need additional information.Source:
http://physiologynews.blogspot.com/2013/01/study-abroad-program-on-mediterranean.html

Sundance Channel to Hold Discussions in The Writers Room

Posted on by

Simply put, count us in for The Writers Room.

The Sundance Channel announced today that it has ordered this unscripted program to series, explaining in a press release:

“We know that much of today’s best entertainment is on television, but Sundance Channel and Entertainment Weekly want to know - who, what, when, where and why?! Social media has given us a lot of information about what our audience is craving - and we are listening. They want insider knowledge and a deeper perspective - this show will deliver that.”

Sundance Channel

None of the show's participants have been announced, but the six half-hour episodes will “spotlight an array of scripted television shows - from today’s pioneering cable dramas to the most critically acclaimed and popular network sitcoms," according to the statement.

In other words: Breaking Bad, Mad Men, Homeland and more.

In other words, to reiterate: count us in.

Source:
http://www.tvfanatic.com/2013/01/sundance-channel-to-hold-discussions-in-the-writers-room/

Spectropia – Mirage and Ghost Stories at the Morbid Anatomy Library: Guest Post by Laetitia Barbier

Posted on by
I am very pleased to introduce the first of what I hope will be many guest posts by Morbid Anatomy Library intern Laetitia Barbier; she has been working with us on and off over the past few years, and has just returned to America to finish her dissertation for The Sorbonne on painter Joe Coleman.
Laeti will be writing a series of short articles for this blog based on her favorite books in the Morbid Anatomy Library; following is her first:

While helping Joanna with the post-Hurricane Sandy library unpacking, I recently stumbled upon this incredible book. Squeezed between larger volumes of the vast “Death and Art” section, this amethyst-colored booklet was so thin that its title was almost impossible to read. “Spectropia or the Surprising Spectral Illusions Showing Ghosts Everywhere and of any Colors” - A rather theatrical headline, rendered on the front cover in a multiple typography layout evoking 19thcentury entertainment posters. The pamphlet cover is also illustrated with a silver, almost invisible hooked nose ghoul, pointing an accusative finger at an even more invisible target. In good condition, the book is in fact a recent facsimile of a Victorian era manual. Its author, J.H. Brown, a complete stranger to me, published it 1864 both in England and in America.

Spetropia- What does it mean? I was both amused by this obscure neologism, and by the idea that the ghosts mentioned in the title did, apparently, not suffer any constraints of space, time or even hue - 'everywhere and of any colors. ' If omnipresence could be a common aspect of spirit's nature, the concept of their polychromatic manifestations was obviously something very new to me and so far incredibly bizarre. It is only by reading the texts and shuffling through the pages of this book that the magical aspect of this treasure item revealed itself to me. 

Spetropia is no necromancy handbook, neither an history of Phantasmagoria spectacles as its macabre iconography might have suggested. It is, instead, an optical illusion manual, a toy book, a pure product of rational amusement. Spectropia in fact suggests that there is no need for a magic lantern operator to create frightening apparitions; your own eyes can serve as a substitute.

Dividing his book in several sections, Mr. Brown explains in his introduction a few simple facts about eye anatomy and their physiological specificities, and also on optic and chromatic learning, so that even young readers could understand that the experiment he proposes is not a metaphysical one, but truly rooted in science.

As he explains, the first step in this intriguing visual path is to pick out your own ghost from the sixteen large lithography plates--a pretty complex dilemma, as those Santa Muerte-like figures vie with each other in terms of amiable whimsicality, reflecting the minimal, almost naïve aesthetic preferred by Brown himself for practical purposes; at one point in the book, he apologies profusely for “the apparent disregard of taste and fine art” of his illustrations. Once your spooky companion is chosen, stare at it for about “a quarter of minute” and then move your eyes to a neutral, preferably white surface: a wall, a sheet of paper or, in my case, the ceiling of the Morbid Anatomy Library. Subsequently, the monochromatic monsters will appear, floating in the air like phosphorescent silhouette, an afterimage produced by the persistence of vision for only few seconds on the retina. As Brown explains it, the illusion will be produced in the complementary color of its original paper doppelganger. For instance, if you were to select the purple hand image (5th down), you will be haunted by a yellow ghost whereas an extended focus on a green one (3rd down) will manifest into a flamingo pink apparition… Spectres, or so it would seem, are true dandies.

But beyond this fantastic imagery, Spectropia has another quite surprising particularity. Brown's main interest was, in fact, not to amuse a young audience; instead, very alarmed by what he called a “mental epidemic” and the superstitious zeitgeist of his era, Mr. Brown was an anti-spiritualist crusader, and his aim was to bring belief in communication with the deceased to an end. By showing through playful optical experiments how ghosts could be seeneverywhere and of any colors, and according to demonstrable scientific principles, Brown's object was to demonstrate how the human mind could so easily and predictably be tricked by deceiving the senses.

A true scientific mind himself, who denies legitimacy to ''the follies of spiritualism,” Brown eventually offers a quiet poetic vision of the limits of his own rationalism when, in his anatomical expose, he describe the eye as “the most wonderful example of the infinite skill of the Creator.”

You can find out more about Laetitia Barbier by clicking here; you can read some of her articles about Parisian curiosities for Atlas Obscura by clicking here. You can find out more about this book--and order a copy of your own!--by clicking here. Very big thanks, also, to my sister Donna Ebenstein for gifting this book to me a number of years back.

All images are scanned from the book; click on image to see larger, more detailed versions.

Source:
http://morbidanatomy.blogspot.com/2013/01/spectropia-mirage-and-ghost-stories-at.html

Skeleton Anatomy and Physiology Review Bones 01 – Video

Posted on by


Skeleton Anatomy and Physiology Review Bones 01
ICI "School of Nursing" in Illinois is here to provide you with another training video of the skeleton. Here we have one of our Nursing Students go over various parts of the skeleton. Learn about our bodies and find out more with ICI! If you #39;re interested in enrolling in our Nursing Program, please feel free to call us anytime at 847-929-6129 for m ore information.

By: ICINURSING

Original post:
Skeleton Anatomy and Physiology Review Bones 01 - Video

Champion joins ranks of full spectrum sports nutrition providers

Posted on by

Another player has entered the arena of companies offering full-spectrum sports nutrition lines with the launch of Champion Nutritions newambition basedline of powdered protein products and supporting supplements.

Champion has been around for about 30 years and they were really primarily body builder focused and performance focused, Forrest Haag, brand manager for Champion, told NutraIngrdients-USA.

They had done some research and realized they needed solutions for everybody and not just body builders.

Champions new line is based on four different protein formulations, dubbed Fit, Endurance, Strength and Sport, each with different types of protein based on the application. With the new launches, Champion joins other sports nutrition players who have recently lintroduced integrated product lines such as Douglas Labs and Thorne Research.

The beauty of this line is we are ambition focused. Its all about where you want to go, Haag said.Its really focused on everybody and on the everyday athlete. Do you want to go further, do you want to lift more?

Plant based proteins

A key facet of the line is the different suit of proteins in each product. While the old workout standbywhey protein isolateforms a key component of two of the lines, proteins from pea, brown rice and potato are also employed, and two of the lines are entirely plant based.

Champion saw an opportunity to tap into an underserved market made up of the 7.5 million vegetarians in the US, 1.8 million of whom are vegans. But, Haag said, the trend toward plant-derived ingredients extends beyond that market base.

If you go to Whole Foods and you look at the protein aisle you are going to see 80-85% whey, 10% soy and the rest is other. And that other is where the market is going to all that other, all the plant-based ingredients. he said.

Link:
Champion joins ranks of full spectrum sports nutrition providers

Latest Progress in Nutrition Will be Discussed at Nutrition and Science 2013

Posted on by

MUMBAI, January 4, 2013 /PRNewswire/ --

The Indian nutrition market is forecasted to grow at a healthy clip for some time. Nutrition and eating habits play key roles in addressing growing health concerns related to obesity, chronic diseases, malnutrition and aging. Fortunately, nutrition and eating habits being key health drivers thus provide a good chance of being able to drive growth. The Nutrition Business Journal (NBJ) forecasted the global nutrition market would exceed $400 billion by 2014 in its 2010 Global Nutrition Report. Thus, this industry in India is expected to grow from INR 44 billion in FY11 to INR 56 billion in FY15.

(Logo: http://photos.prnewswire.com/prnh/20130104/586465)

Functional foods and beverages are a core segment of the nutrition market for packaged nutrition products. Functional foods and beverages refer to products that have been fortified to achieve specific health benefits. Prominent examples of functional foods and beverages include sports and energy drinks, vitamin and antioxidant-enriched milk and juices, whole grains and other products fortified with omega-3 fatty acids (fish oil) and probiotic yogurt products (which contain microorganisms that aid digestion). The market for global clinical nutrition products is expected to reach $34.5 billion by 2015, according to a GIA study. Infant nutrition is the largest and fastest growing segment in the global clinical nutrition products market. Clinical nutrition products include infant formula with protein, antioxidants, probiotics, prebiotics, enriched and omega-3 fatty acids such as ARA, EPA and DHA. However, unclear regulatory guidelines for labelling and nutritional claims and lack of consumer awareness act as a barrier in this sensitive industry.

To delve deeper into latest nutrition-related regulatory aspects, novel nutritional ingredients, science behind various nutritional categories, Fi Conferences is organising Nutrition and Science 2013 from 13-15 February in Mumbai, India. The main objective of this conference is to gain in-depth guidance on nutritional and labelling claims and achieve technical brilliance to develop consumer specific world class nutritional products. The two-day conference will be initiated with a series of invited lectures by our esteem panel of speakers including Pradip Chakraborty, Director - Zonal (Product Approval), FSSAI; DP Attrey, Convener of the Sub Group, Scientific Panel on Labelling and Claims, FSSAI; Anoop Misra, Director and Head, Department of Diabetes and Metabolic Diseases, Fortis Group of Hospitals; Sanjeev Ganguly, Medical Director - South Asia, Nestle Nutrition; Peter McConville, Vice President - R&D Nutrition Category, GlaxoSmithKline Consumer Healthcare; Eline M van der Beek, Research Director, Danone Research Centre for Specialised Nutrition and many more. Workshop on Food Clinical Trials will be conducted on 15 February by Sadanand Kulkarni, Vice President Medical Affairs and Clinical Research, Fresenius Kabi and Brijesh Regal, CEO, Apothecaries Clinical Research.

This unique three-day strategic conference will bring together 100+ Vice Presidents, Directors, Heads of Nutrition, R&D, Production Development professionals from food, beverage and pharmaceutical companies all under one roof. For more information, visit http://www.food-nutritionscience.com/pr [http://www.food-nutritionscience.com/pr ].

About UBM India:

UBM India is a subsidiary of UBM plc, which is the second largest independent exhibition organiser in the world. It is the largest trade exhibition organiser in India, responsible for 26 exhibitions in different locations across the country. The company is also involved in the organisation of conference programmes throughout India and in the publications of trade journals and magazines. For further details please visit the UBM India website, http://www.ubmindia.in [http://www.ubmindia.in ]

About Food Ingredients India (Fi India):

Launched in 2006, Fi India has been known as a driving force to Indias processed food sector and has a fundamental role as facilitating the industrys only meeting place. Both regional and global food professionals use this opportunity to learn about the latest industry developments, meet new business prospects and launch new products to gain competitor advantage in the fastest growing food marketplace in the world.

Continue reading here:
Latest Progress in Nutrition Will be Discussed at Nutrition and Science 2013

Collaboration through the IRCSET Enterprise Partnership Scheme – Video

Posted on by


Collaboration through the IRCSET Enterprise Partnership Scheme
Teagasc have been working with OGT (Oilean Glas Teo) for 7 months on assessing the effect of seaweed extracts on the quality of Horticultural produce and also the effect the addition of seaweed extracts has on soil microbiology. The video above features Dr. Theodora Lola-Luz, a Post Doctoral Researcher working at Teagasc.

By: TeagascMedia

Read this article:
Collaboration through the IRCSET Enterprise Partnership Scheme - Video

Hamilton County denies longevity pay for magistrate

Posted on by

Larry Ables, Hamilton County's chief magistrate. Photo by Dan Henry /Chattanooga Times Free Press.

Hamilton County magistrates' pay and benefits once again came under the County Commission's microscope this week as commissioners questioned what benefits are appropriate for the position.

The Hamilton County Commission voted unanimously to deny longevity pay for Magistrate Larry Ables, who has been trying since last fall to resolve a number of pay and benefits issues in his contract.

Longevity pay is granted to Hamilton County employees after their first five years of service. But the magistrate position does not fall under the county's employee handbook guidelines, argued Commissioner Joe Graham.

"We have to re-elect these positions every year. So I don't personally see how anyone can build longevity pay since it's just a one-year job," Graham said. Magistrates' contracts need to be clarified, he said.

Ables has been a magistrate -- setting bonds and signing warrants at the Hamilton County Jail -- since 2007, and has been chief magistrate since 2008. The commission voted last October to keep Ables as magistrate for another year, but also chose Magistrate Randy Russell to replace Ables in the supervisory position, prompting a number of questions about how benefits carried over in the position.

The commission has had to take on the awkward task of resolving recent specific benefits dilemmas because of the complicated magistrates structure.

Magistrates hold their contracts solely with the County Commission and do not fall under the purview of general county government.

But the magistrates technically are supervised by the state, and the commission handles no day-to-day oversight of the magistrates office beyond appointing new ones each year. There has been no real precedent for how to deal with the questions involving magistrates' benefits.

The commission has already debated pay issues for Ables. In October, they mulled over whether to pay Ables about $2,000 in paid leave that he said he earned at the salaried rate he had as chief magistrate, which makes a higher salary than magistrate.

More here:
Hamilton County denies longevity pay for magistrate

Genetic link to longevity identified

Posted on by

Washington, January 4 (ANI): Researchers have uncovered a link between a certain genetic variation - associated with active personality traits in humans - and longer life.

This derivative of a dopamine-receptor gene - called the DRD4 7R allele - appears in significantly higher rates in people more than 90 years old and is linked to lifespan increases in mouse studies.

Robert Moyzis, professor of biological chemistry at UC Irvine, and Dr. Nora Volkow, a psychiatrist who conducts research at the Brookhaven National Laboratory and also directs the National Institute on Drug Abuse, led a research effort that included data from the UC Irvine-led 90+ Study in Laguna Woods, Calif.

The variant gene is part of the dopamine system, which facilitates the transmission of signals among neurons and plays a major role in the brain network responsible for attention and reward-driven learning. The DRD4 7R allele blunts dopamine signaling, which enhances individuals' reactivity to their environment.

People who carry this variant gene, Moyzis said, seem to be more motivated to pursue social, intellectual and physical activities. The variant is also linked to attention-deficit/hyperactivity disorder and addictive and risky behaviors.

"While the genetic variant may not directly influence longevity," Moyzis said, "it is associated with personality traits that have been shown to be important for living a longer, healthier life. It's been well documented that the more you're involved with social and physical activities, the more likely you'll live longer. It could be as simple as that."

Numerous studies - including a number from the 90+ Study - have confirmed that being active is important for successful aging, and it may deter the advancement of neurodegenerative diseases, such as Alzheimer's.

Prior molecular evolutionary research led by Moyzis and Chuansheng Chen, UC Irvine professor of psychology and social behavior, indicated that this "longevity allele" was selected for during the nomadic out-of-Africa human exodus more than 30,000 years ago.

In the new study, the UC Irvine team analyzed genetic samples from 310 participants in the 90+ Study. This "oldest-old" population had a 66 percent increase in individuals carrying the variant relative to a control group of 2,902 people between the ages of 7 and 45. The presence of the variant also was strongly correlated with higher levels of physical activity.

Next, Volkow, neuroscientist Panayotis Thanos and their colleagues at the Brookhaven National Laboratory found that mice without the variant had a 7 percent to 9.7 percent decrease in lifespan compared with those possessing the gene, even when raised in an enriched environment.

See the rest here:
Genetic link to longevity identified

Longevity Global Inc Announces a New Range of Welder Equipment for DIY

Posted on by

Catering the requirement for durable and high-end welder equipment for DIY, Longevity Global Inc has become a reliable name.

Hayward, Ca (PRWEB) January 04, 2013

Innovation is the Mantra here for more than a decade now. The company provides durable and higher performance welder machines to users designed and developed through innovation, customer satisfaction, and industry leading production. It also brings welders for sale wherein it sells them at attractively lower prices to meet the requirements from the clients who have shoe-string budget.

Talking about the intrinsically designed welders, a company representative says, Through innovation, experience, and engineering, we provide customer with affordable and reliable welding machines in all ranges of production from the garage users, to pipe welders, and ship builders. He further assures that the warranty is tailored to the end users for enhanced user-experience.

Longevity Global Inc is known for offering prime quality welding equipment and even encourages potential customers to check out the products in person at its premises. Customers need to schedule their visit in advance for it is time consuming. They can visit production center at 23591 Foley St, Hayward CA 94545 to see what we are up to.

The company has global partners and distributors in the countries such as Brazil, Australia, UK, Mexico, Canada and others from where customers can buy prime quality durable welding equipment at affordable costs.

About the company:

LONGEVITY Global Inc is recognized worldwide for providing reliable welding, and power generating equipment. Since its inception 2001, LONGEVITY Global Inc has earned the slogan, "The Power to Last" through innovation, customer satisfaction, and industry leading production. Welding, cutting, and power generating equipment from the company have exceptional quality and durability achieved through R &D department. It has no excuse DOA policy, and samples products to the top welders in the United States to receive crucial feedback, which drives innovation.

For more information please visit http://www.longevity-inc.com

Simon Katz Longevity, Inc. 1.877.566.4462 Email Information

Visit link:
Longevity Global Inc Announces a New Range of Welder Equipment for DIY

Longevity Global Inc Has Put All Its TIG Welders for Sale

Posted on by

Longevity Global Inc has announced cost cuts on all its TIG Welders. The discount is valid on all the TIG welding machines including one welding machine, DC TIG Weld 200(ARC output 5-160 AMP) at 60% duty cycle.

Hayward, Ca (PRWEB) January 05, 2013

The AC/DC TIG Welding is meant for all metals including Aluminum. TIG Welder for sale is for limited time period only.

The benefit of using TIG welding equipment is its ability to be ambidextrous. When the welder begins to use the left and right hand simultaneously in any process, there is more stress involved. TIG welders dont feel the same stress as that of other welders. More discussion and threads over TIG Welding can be seen at the companys TIG welding forum.

Longevity Global Inc ensures quality examination of each and every product, before it reaches its true owners. The company also offers a hassle free 5 year warranty on parts and label. Through their innovative and smart engineering methods, Longevity Global Inc ensures reliable and affordable welding machines in all ranges of production.

With its international distributors in Canada, UK, Mexico, Brazil, Australia, and many other countries, Longevity Global Inc global manufacturing facilities are making its mark with its outstanding and effective services of distributing products on time, even before time. With its excellent support and services, Longevity Global Inc believes in structuring an immense ethical and professional relationship with its customers. That is why Longevity Global Inc has the power to last.

About the company:

LONGEVITY Global Inc is recognized worldwide for providing reliable Welding, and power generating equipment. Since its inception 2001, LONGEVITY Global Inc has earned the slogan, "The Power to Last" through innovation, customer satisfaction, and industry leading production. LONGEVITY welding, cutting, and power generating equipment has exceptional quality and durability achieved through our R and D department, our no excuse DOA policy, and our rigorous testing procedures led by our engineers. LONGEVITY Global Inc also samples products to the top welders in the United States to receive crucial feedback, which drives our innovation.

For more information, visit http://www.longevity-inc.com

Simon Katz Longevity, Inc. 1.877.566.4462 Email Information

Read more here:
Longevity Global Inc Has Put All Its TIG Welders for Sale