Copper Thermal Link Flexibility Demonstration- Technology Applications, Inc. – Video


Copper Thermal Link Flexibility Demonstration- Technology Applications, Inc.
TAI manufactures the world #39;s highest quality copper thermal straps (thermal links) for cryogenics and aerospace applications. Our straps offer superior flexibility and thermal conductivity over all other thermal links. Call TAI today to get an assessment of and find a solution to your cryogenics or aerospace thermal management problems. 303.867.8145From:TechAppsIncViews:0 0ratingsTime:00:12More inGaming

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Copper Thermal Link Flexibility Demonstration- Technology Applications, Inc. - Video

Doom 3 BFG – Alpha Labs – Sector 1: Union Aerospace Science Division – Video


Doom 3 BFG - Alpha Labs - Sector 1: Union Aerospace Science Division
Doom 3 BFG - Alpha Labs - Sector 1: Union Aerospace Science Division Players: MooMoo 24 Alpha Labs - Sector 1: Union Aerospace Science Division is the fifth level of Doom 3. Built in 2095 and located on Site 2, Alpha is the UAC #39;s center research lab. Sector 1 houses the EPD (Elemental Phase Deconstructor) and the Hydrocon. Maggots are introduced midway through the level in a cutscene.From:PartyCow2000Views:2 0ratingsTime:16:28More inGaming

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Doom 3 BFG - Alpha Labs - Sector 1: Union Aerospace Science Division - Video

Kerbal Space Program Episode 6: Successful Flights are Successful – Video


Kerbal Space Program Episode 6: Successful Flights are Successful
Hey Kids! Uncle DragonWyrm is back with another venture into the world of Aerospace engineering! Today we test our mettle with 3 different plane/rocket designs. RSI Aurora Download link: forum.kerbalspaceprogram.comFrom:DragonWyrmViews:2 0ratingsTime:26:14More inGaming

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Kerbal Space Program Episode 6: Successful Flights are Successful - Video

Ball Aerospace OMPS Instrument Delivers 2012 Ozone Measurements

BOULDER, Colo., Oct. 24, 2012 /PRNewswire/ -- Ball Aerospace & Technologies Corp.'s Ozone and Mapping Profiler Suite (OMPS) has made its first ozone measurements of the Antarctic ozone hole since launching aboard NASA's Suomi National Polar-orbiting Partnership (NPP) satellite on Oct. 28, 2011.

(Photo: http://photos.prnewswire.com/prnh/20121024/LA98688)

According to NASA and NOAA, the 2012 satellite measurement map of the Antarctic ozone hole shows that it is the second-smallest in 20 years since it appeared in the early 1980s.This is the first year Ball's OMPS instrument is providing the ozone data, continuing a satellite record dating from the early 1970s.

Under contract to NASA, Ball Aerospace designed and built OMPS and the Suomi NPP satellite, and integrated all five of the satellite's instruments. Suomi NPP orbits Earth every 102 minutes, and to date has completed 5,000 orbits capturing data from the Earth's land, oceans and atmosphere. Currently Ball is building Suomi NPP's successor, the Joint Polar Satellite System-1 (JPSS-1) satellite and its OMPS instrument, to maintain continuity of weather and environmental observations into the 2030s by providing a daily map of the entire globe's ozone.

"Science and society are greatly benefitting from the successful delivery of data from the new set of instruments aboard Suomi NPP as it prepares our nation for the next-generation of polar-orbiting weather satellites," said David L. Taylor, Ball Aerospace president and CEO. "Suomi NPP and JPSS-1 allow more accurate global environmental predictions and improve weather forecasts for millions of people."

Ball's OMPS instrument measures atmospheric ozone and how ozone concentration varies with altitude. The three-part instrument includes a nadir profiler, to help scientists better understand ozone destruction in the middle and upper stratosphere; a limb profiler, to discern lower stratospheric ozone variations; and a nadir mapper to analyze daily global total ozone maps. Ball's OMPS is based on its previous instrument, the Solar Backscatter Ultraviolet instrument (SBUV/2).

This year's Antarctic ozone hole size reduction is attributed to warmer conditions over that continent. The average size of the 2012 ozone hole was 6.9 million square miles, compared to 11.5 million square miles in 2000. Even though it is smaller than in years past, the ozone layer above Antarctica is not expected to return to its early 1980s state until about 2065. The NASA/NOAA collection of ozone data contributes to fulfilling the monitoring requirements of the Montreal Protocol, a 1989 international treaty.

Ball Aerospace & Technologies Corp. supports critical missions for national agencies such as the Department of Defense, NASA, NOAA and other U.S. government and commercial entities. The company develops and manufactures spacecraft, advanced instruments and sensors, components, data exploitation systems and RF solutions for strategic, tactical and scientific applications. For more information visit http://www.ballaerospace.com.

Ball Corporation (BLL) is a supplier of high quality packaging for beverage, food and household products customers, and of aerospace and other technologies and services, primarily for the U.S. government. Ball Corporation and its subsidiaries employ more than 14,500 people worldwide and reported 2011 sales of more than $8.6 billion. For the latest Ball news and for other company information, please visit http://www.ball.com.

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Ball Aerospace OMPS Instrument Delivers 2012 Ozone Measurements

Aerospace industry raises funds for Habitat home

Bay Area-Houston and Habitat for Humanity held its second annual Aerospace Games last week.

Ten companies participated in the event along with volunteers from the community to raise funds to build a home for a family in need.

Aerospace Project Build was created by companies within the aerospace industry to take part in the funding of Habitat homes throughout the Bay Area and other surrounding cities.

The companies represented teams that participated in a variety of round robin events with the winning team designated to raise the walls at a Habitat home.

This year, that honor will go to the employees at UTC Aerospace Systems, who raised $7,000 from their own volunteer fundraising efforts.

Each team that participated at last weeks event will spend every weekend throughout the building process of a new Habitat home.

United Space Alliance, Boeing, NASA, Bastion Technologies and JSC Federal Credit Union were just a few of the companies participating in this years games.

Organizers set their goal at increasing the participation and money raise, said Rachel Ward, resource development coordinator for Bay Area Habitat for Humanity-Houston.

This years Aerospace Games raised between 45-$50,000 compared to last years $30,000.

Our goal was to increase the event by 50 percent and we were able to do that exactly financially and by the number of people that participate, said Ward.

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Aerospace industry raises funds for Habitat home

B/E Aerospace Reports Third Quarter 2012 Financial Results; EPS $0.74 Excluding Debt Prepayment Costs; Raises 2012 …

WELLINGTON, Fla.--(BUSINESS WIRE)--

B/E Aerospace, Inc. (BEAV), the worlds leading manufacturer of aircraft cabin interior products and the worlds leading distributor of aerospace fasteners and consumables, today announced third quarter 2012 financial results.

THIRD QUARTER 2012 HIGHLIGHTS VERSUS THIRD QUARTER PRIOR YEAR

THIRD QUARTER CONSOLIDATED RESULTS

Third quarter 2012 revenues of $766.7 million increased $130.7 million, or 20.6 percent, as compared with the same period of the prior year. Organic revenue growth, excluding 2012 acquisitions, was 10.5 percent.

Operating earnings, adjusted to exclude $4.6 million of AIT costs, were $138.9 million, an increase of 23.9 percent, and operating margin of 18.1 percent increased 50 basis points as compared to the prior year period. The growth in operating earnings and the improvement in operating margin occurred primarily as a result of operating leverage at the higher sales volume and ongoing operational efficiency initiatives. Operating earnings, on a GAAP basis to include AIT costs, were $134.3 million or 17.5 percent of sales.

Net earnings and earnings per diluted share, adjusted to exclude both one-time debt prepayment costs and AIT costs, were $79.2 million and $0.77 per diluted share, increases of 21.1 percent and 20.3 percent, respectively, as compared to the prior year period. Net earnings and net earnings per diluted share, adjusted to exclude the one-time debt prepayment costs, were $76.0 million and $0.74 per diluted share.

Commenting on the Companys third quarter 2012 performance, Amin J. Khoury, Chairman and Chief Executive Officer of B/E Aerospace said, Our revenue growth continues to be driven primarily by the robust new aircraft delivery cycle. Approximately 61 percent of third quarter revenues were driven by demand for products for new-buy aircraft reflecting both robust new aircraft deliveries and weaker aftermarket demand. In addition, as a result of our operational outperformance which has resulted in record operating earnings for the nine-month year-to-date period, and successfully executed tax planning initiatives we have been able to raise our 2012 earnings guidance to $2.82 per share. The $2.82 per share guidance represents a $0.17 per share increase as compared to our original guidance of $2.65 per share.

For 2013, we are expecting top line growth of approximately 10 percent driven primarily by the demand for our products for new-buy aircraft. Our initial 2013 guidance of approximately 10 percent revenue growth and approximately 20 percent earnings per share growth is based primarily on our high quality backlog and the expectation of strong wide-body deliveries that are expected to continue for the next several years. We believe we are well positioned to generate double-digit revenue growth for the next several years, based on our total backlog of $8.25 billion, both booked and awarded but unbooked, rapidly growing revenues from our supplier furnished equipment (SFE) program deliveries, our expectation for a 14 percent CAGR in wide-body aircraft deliveries over the next three years, the expectation for continued growth in global passenger travel, and the attendant increases in capacity.

THIRD QUARTER SEGMENT RESULTS

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B/E Aerospace Reports Third Quarter 2012 Financial Results; EPS $0.74 Excluding Debt Prepayment Costs; Raises 2012 ...

ST Aerospace's VIP Completion Business Signs Major Contract for Boeing 767-200ER VIP aircraft

Singapore, 29 October 2012 ST Aerospaces VIP completion business, AERIA Luxury Interiors (AERIA) has been selected by an unnamed customer for the interior modification of a Boeing 767-200ER VIP aircraft. AERIAs scope of work for the modification is all-inclusive, and extends from design, engineering and installation to project management. This is AERIAs second contract, following its successful redelivery of a Boeing Business Jet in August. AERIA was first unveiled at the Singapore Airshow in February this year.

Notably, the contract includes heavy maintenance of the aircraft, bearing testament to ST Aerospaces integrated solutions for customers. In an arrangement that will minimise aircraft downtime for the customer, AERIA will perform the interior modification when the aircraft is stripped of its cabin fittings during heavy maintenance. The heavy maintenance will be undertaken by ST Aerospaces US affiliate STA San Antonio, which AERIA is a division of. Both are located in the same facility at San Antonio, Texas. The aircraft is expected to be inducted next month and redelivered in April 2013.

We are privileged to be selected as our customers preferred VIP completion centre. This contract is a vote of confidence in AERIAs capabilities and we are committed to surpassing our customers expectations with an exceptional design, flawless execution and timely delivery. ~ Ron SORET, General Manager of Completions, AERIA Luxury Interiors, STA San Antonio

We are looking forward to providing our customer with a seamless experience. The integration of AERIAs interior expertise with STA San Antonios maintenance resources will allow the customer to enjoy the highest quality of service in the best lead time." ~ Stephen LIM, President, STA San Antonio

AERIA will undertake the modification of the aircrafts in-flight entertainment setup to include a new surround sound speaker system and high definition monitors; engineering of interior door locks; installation of a trash compartment and refrigerator/freezer; as well as design of a new interior soft goods palette, including leathers, divan fabrics, deco panels and headliners.

AERIA is backed by a team with well established expertise in VIP completions, engineering and all related support activities. The management team collectively has nearly 150 years of experience and has performed completions on more than 50 aircraft. Being part of the global network of ST Aerospace, which is the worlds leading aircraft engineering and maintenance service provider, AERIA is able to offer customers unparalleled support.

AERIA is strategically located in San Antonio for its highly trained engineering talent pool and cluster of supporting businesses for VIP completions. San Antonio is well regarded as the birthplace of VIP completions for large aircraft, with roots from the 1980s.

ST Aerospace (Singapore Technologies Aerospace Ltd) is the aerospace arm of ST Engineering. Operating a global MRO network with facilities and affiliates in the Americas, Asia Pacific and Europe, it is the worlds largest commercial airframe MRO provider with a global customer base that includes leading airlines, airfreight and military operators. ST Aerospace is an integrated service provider that offers a spectrum of maintenance and engineering services that include airframe, engine and component maintenance, repair and overhaul; engineering design and technical services; and aviation materials and management services, including Total Aviation Support. ST Aerospace has a global staff strength of more than 8,000 engineers and technical specialists. Please visit http://www.staero.aero.

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ST Aerospace's VIP Completion Business Signs Major Contract for Boeing 767-200ER VIP aircraft

Sikorsky Aerospace Services Announces Selection of Altus, Oklahoma, as Site for Full Service Flight and Maintenance …

SHELTON, Conn., Oct. 26, 2012 /PRNewswire/ --Sikorsky Aerospace Services (SAS) today announced the signing of a Memorandum of Understanding (MOU) with Aviation Training Consulting (ATC) to establish an advanced flight and maintenance training academy, the Sikorsky Training Academy (STA), in Altus, Okla. SAS is the worldwide aftermarket business of Sikorsky Aircraft Corp., a subsidiary of United Technologies Corp. (UTX).

(Logo:http://photos.prnewswire.com/prnh/20060403/SIKORSKYLOGO )

"Many of our customers, particularly U.S. Government agencies and foreign militaries, have difficulty obtaining thorough standardized training for their flight crews and maintenance teams. In particular, there is a lack of advanced mission training beyond basic conversion courses and currency training. Many customers rely on training companies that are neither U.S. military nor Sikorsky qualified," said David Adler, President of Sikorsky Aerospace Services. "Establishing this center is a significant step in enabling us to deliver a comprehensive, tailored OEM training curriculum of the highest standards, capable of preparing our students for a wide variety of missions."

Projected to launch in 2013, the academy will initially focus on meeting the needs of foreign militaries using the BLACK HAWK helicopter as the training platform. Altus, Okla., located near Fort Sill, provides the training academy with access to several hundred square miles of operating space, certified landing areas, and certified night vision routes. Additionally, Altus weather conditions are well suited to flight training schedules.

SAS is proposing to team in the development of the STA with Aviation Training Consulting, an Altus-based firm and an industry leader in designing and providing advanced training solutions. Sikorsky has entered into an MOU with ATC and is in the process of final discussions for establishing the academy. ATC has existing relationships with Sikorsky's customers.

"The creation of the STA is a natural progression of our relationship with Sikorsky and will not only benefit Sikorsky and ATC, it would make Altus a key global destination of choice for advanced military aircraft training," said Robert Cox, CEO of ATC. "Oklahoma is proud of its rich aerospace and defense industry, which represents approximately 10 percent of its economy. We look forward to the development of the training academy and our association with Sikorsky, an internationally respected company."

SAS provides comprehensive support to rotary and fixed wing aircraft throughout the world. It offers its military and commercial operators a full portfolio of support services, including material distribution, maintenance, overhaul & repair, aircraft modifications and life-cycle support. Sikorsky, based in Stratford, Conn., is a world leader in helicopter design, manufacture, and service. United Technologies Corp., based in Hartford, Conn., provides a broad range of high technology products and support services to the aerospace and building systems industries.

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Sikorsky Aerospace Services Announces Selection of Altus, Oklahoma, as Site for Full Service Flight and Maintenance ...

LMI Aerospace Announces Conference Call to Discuss 2012 Third Quarter Results

ST. LOUIS, Oct. 24, 2012 (GLOBE NEWSWIRE) -- LMI Aerospace, Inc. (LMIA), a leading provider of design engineering services, structural assemblies, kits and components to the aerospace, defense and technology markets, today announced that it will host a conference call to discuss the company's third quarter 2012 results.

The conference call will be Thursday, November 8, 2012, at 9:00 A.M., CST. LMI Chief Executive Officer Ronald S. Saks, Chief Operating Officer Ryan P. Bogan and Chief Financial Officer Lawrence E. Dickinson will host the call. LMI plans to release the company's third quarter 2012 results just prior to market open on November 8.

To participate in the call, please dial 866.307.3343 approximately five minutes before the conference call time stated above. A live webcast of the call can be accessed directly from the LMI Aerospace web site at http://ir.lmiaerospace.com/events.cfm and by clicking on the appropriate link. A recording of the call will be available on the LMI web site upon completion of the call.

LMI Aerospace, Inc. is a leading provider of design engineering services, structural assemblies, kits and components to the aerospace, defense and technology markets. Through its Aerostructures segment, the company primarily fabricates machines, finishes, integrates, assembles and kits formed close tolerance aluminum and specialty alloy and composite components and higher level assemblies for use by the aerospace, defense and technology industries. It manufactures more than 30,000 products for integration into a variety of aircraft platforms manufactured by leading original equipment manufacturers and Tier 1 aerospace suppliers. Through its Engineering Services segment, operated by its D3 Technologies, Inc. subsidiary, the company provides a complete range of design, engineering and program management services, supporting aircraft product lifecycles from conceptual design, analysis and certification through production support, fleet support and service life extensions via a complete turnkey engineering solution. Additional information can be found at http://www.lmiaerospace.com

The LMI Aerospace, Inc. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=4971

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LMI Aerospace Announces Conference Call to Discuss 2012 Third Quarter Results

New Company, R2 Aerospace, Established By Former Yankee Pacific Aerospace VP

A new company, R2 Aerospace, has been established by former Yankee Pacific Aerospace (YPA), Inc., vice-president of business development and founding shareholder, Rick Richardson. R2 Aerospace will pursue new opportunities in aircraft industry manufacturing and MRO in Tulsa, Oklahoma. Richardson has extensive experience over his 26-year career across all aspects of large aircraft interior completions.

Richardson will continue to provide technical and marketing support for YPA under a consulting agreement. R2 Aerospace president, Rick Richardson, said, The establishment of R2 Aerospace is an exciting venture which will provide many opportunities for aircraft industry growth within manufacturing and MRO across the Tulsa region.

My past experience in managing and forming aviation companies, in addition to my extensive knowledge and contact base within the industry, places me in good stead to provide R2 Aerospace clients with outstanding customer service.

YPA, LLC, managing director, Ken Goldsmith, said, Rick made a major contribution to the growth of Yankee Pacific Aerospace during his tenure with the company. We look forward to continuing our consulting relationship and wish him equal success as he pursues his new venture.

Richardson and Goldsmith teamed up in 2002 at Lufthansa Technik AG in Hamburg, Germany, to form Lufthansa Technik Completion Engineering, LLC, in Tulsa. After acquiring Lufthansas stake in 2004 and forming Executive Aircraft Completions, LLC (EAC), Richardson and Yankee Pacific went on to merge EAC into Yankee Pacific Aerospace, Inc., a company formed by Yankee Pacific and Richardson in 2006 with private equity firm, Hancock Park Associates. YPA subsequently acquired Jormac Aerospace in 2006 and Cabin Innovations in 2007, before going on to form Aircraft Systems Division in 2011. Starting in 2002, Richardson rose from vp of engineering at LTCE to vp-general manager at EAC, then to president of Cabin Innovations and finally to vp of business development at YPA.

From 1985 to 1993, Richardson was an avionics & electrical design engineer at Dassault Falcon Jet and an electrical design engineer at Arkansas Aerospace. From 1993 until 2002, he held positions as project engineer, DAS administrator and director of engineering & certification at Bombardier, where he led the completions engineering group in Tucson, Arizona, and Montreal, Canada. He studied engineering at the University of Arkansas at Little Rock and holds a delegation from the FAA as a Delegated Engineering Representative (DER) in mechanical systems and equipment.

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New Company, R2 Aerospace, Established By Former Yankee Pacific Aerospace VP

Parker Aerospace’s Advanced Flight Controls Certified on Gulfstream G650 Business Jet

IRVINE, Calif.--(BUSINESS WIRE)--

The fly-by-wire actuation system developed by Parker Aerospace, a business segment of Parker Hannifin Corporation (PH), the global leader in motion and control technologies, has been certified as part of the type certificate Gulfstream received from the Federal Aviation Administration (FAA) for its Gulfstream G650 business jet.

Gulfstream Aerospace Corporations ultra-large-cabin, ultra-long-range G650 received FAA certification on September 7, 2012. Gulfstream and the Parker Aerospace Control Systems Division have been working together since the program's launch to design and certify the G650s fully digital, fly-by-wire flight control system, which includes the worlds first three-axis business aircraft electric backup hydrostatic actuation (EBHA) subsystem.

EBHAs are electrically controlled actuators that are primarily hydraulically powered by one of the G650s two hydraulic systems, with electric power as a backup. The EBHA subsystem is self-contained, operating in the event of certain failure conditions, essentially eliminating the need for a third hydraulic system found in traditional aircraft system architectures. These actuators provide enhanced aircraft safety and flight control availability because of the different power sources.

Parker provides EBHAs for all the G650s primary control surfaces, including the elevator, rudder, aileron, and outboard multi-function spoiler. In addition, Parker provides electrohydraulic servoactuators (EHSAs) for all of the G650s primary control surfaces as well as remote electronics units, motor control electronics, and tubing assemblies. The flight control actuators are manufactured at the Parker Aerospace Control Systems Division facility in Ogden, Utah, with the electronics manufactured at the divisions headquarters in Irvine, California.

The G650s fly-by-wire flight control system delivers many benefits, including flight-envelope protection, passenger comfort, increased redundancy, and reduced maintenance. As noted by Gulfstream in a recent statement, the system is the result of extensive testing, leading to a redundant fly-by-wire system that exceeds certification requirements.

Parker Aerospace helped make business aviation history when the G650 completed flight with EBHA mode on December 21, 2010. It became the first business aircraft to control flight using an electrically powered, fly-by-wire, EBHA backup flight control actuation system.

Parker is thrilled to have its components on the now-certified Gulfstream G650, said Parker Aerospace Vice President of Operations Greg Crowe. We are proud to be a part of this game-changing aircraft and showing what our advanced, fly-by-wire flight controls can achieve.

When flight with EBHA mode was completed, Gulfstream Senior Vice President of Programs, Engineering, and Test Pres Henne said, "The system performed flawlessly. There was no difference in handling qualities between the electrically and hydraulically powered modes.

About Parker Aerospace. Parker Aerospace is a global leader in the research, design, manufacture, and service of flight control, hydraulic, fuel and inerting, fluid conveyance, thermal management, and engine systems and components for aerospace and other high-technology markets. It is an operating segment of Parker Hannifin Corporation.

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Parker Aerospace’s Advanced Flight Controls Certified on Gulfstream G650 Business Jet

Nextant Aerospace Displays Its 400XT Business Jet at the 65th NBAA Annual Meeting in Orlando

CLEVELAND & ORLANDO, Fla.--(BUSINESS WIRE)--

Nextant Aerospace, maker of the 400XT, the worlds only remanufactured business jet, today announced that it will display the 400XT at the 65th National Business Aviation Association (NBAA) Annual Meeting and Convention, taking place October 30 to November 1, 2012, at the Orange County Convention Center in Orlando, Florida. The companys indoor exhibit will be located at booth number 4423 in the convention center; the aircrafts static display position at Orlando Executive Airport is #625.

Nextant will hold a press briefing at the Orange County Convention Center:

Time and location:

The press conference will be led by Nextant Aerospace founder and chief executive officer Kenneth C. Ricci, and will be followed by an open Q&A session for members of the media.

Nextants static display at Orlando Executive Airport will also serve as the setting for a reception to celebrate the one-year anniversary of the planes certification by the FAA:

Time and location:

When we displayed at last years NBAA in Las Vegas, the 400XT had just received final FAA certification, said Kenneth C. Ricci, CEO of Nextant Aerospace. Since then, the markets reception of the 400XT has been incredible. By the end of this year, we anticipate delivery of 25 aircraft, and will enter next year with a sales backlog valued in excess of $175 million. The current order book includes firm orders from six different countries, with 40 percent of our total sales occurring internationally. We are looking forward to showcasing an even more advanced 400XT at this years event.

Among the developments being showcased at this years NBAA will be Nextants new raked winglet, which provides improved performance, both while climbing and during high-speed cruising at altitude. The winglets, the first of their kind on a business jet, are expected to be certified by the end of the first quarter of 2013.

The winglets unique design and carbon fiber construction minimize additional wing loading, while maximizing the overall aerodynamic efficiency of the aircraft. They also feature all-new, low maintenance LED lighting, replacing a heavier strobe lighting system, which further decreases weight. The winglets will be a standard feature on the 400XT going forward, and all 400XTs that have been delivered to date will be retrofitted.

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Nextant Aerospace Displays Its 400XT Business Jet at the 65th NBAA Annual Meeting in Orlando

Broadening Study of Mitochondrially Targeted Compounds

Mitochondria, the cell's herd of bacteria-like power plants, occupy an important position in processes of aging, metabolism, and many age-related conditions. Mitochondria produce damaging reactive oxidative molecules as a side-effect of their operation, and these can cause all sorts of havoc - such as by damaging mitochondrial DNA in ways that can propagate throughout the mitochondrial population of a cell, causing it to run awry and harm surrounding tissue. This happens ever more often as we age, and is one of the principle contributions to degenerative aging.

It is worth noting that a greater ability of mitochondria to resist this sort of self-inflicted oxidative damage is theorized to explain much of the longevity of many species that are unusually long-lived for their size - such as bats, naked mole-rats, and so forth.

Thus the researcher community is increasingly interested in finding ways to target therapies to mitochondria: to slow oxidative damage, fix that damage, repair other issues such as genetic disorders in mitochondrial DNA, or alter mitochondrial operation as a way of manipulating cellular behavior and metabolic processes. Building such a therapy usually means attaching a payload molecule to a delivery molecule or particle that will be (a) taken up by a cell, passing through the cell membrane, and then (b) swallowed by a mitochondrion within the cell, passing through that mitochondrion's membranes.

A range of different research groups are working on varied forms of delivery technology. Compare, for example, the repurposed protein machinery of rhTFAM with various plastinquione compounds or polymer nanoparticles. Or, more deviously, genetic engineering that makes a cell nucleus produce and export proteins to that cell's mitochondria. There are many others.

Diversity is a good thing - though of course not all of these strategies are equal in the sort of interventions that they can support. There is a world of difference between introducing more antioxidants into the mitochondria so as to blunt their creation of damaging, reactive byproducts and introducing new genes to repair damage to mitochondrial DNA. The former only gently slows the inevitable, while the latter reverses and repairs the harm done.

In any case, here is a paper representative of work taking place in the targeted antioxidant camp, much of which is taking place in Moscow research centers. Given a few years of promising studies, they are going on to explore the space of possible related compounds, in search of drug candidates that might do as well or better as those discovered to date.

Novel penetrating cations for targeting mitochondria

Novel penetrating cations were used for a design of mitochondria-targeted compounds and tested in model lipid membranes, in isolated mitochondria and in living human cells in culture. Rhodamine-19, berberine and palmatine were conjugated by aliphatic linkers with plastoquinone possessing antioxidant activity. These conjugates (SkQR1,SkQBerb, SkQPalm) and their analogs lacking plastoquinol moiety (C12R1,C10Berb and C10Palm) penetrated bilayer phospholipid membrane in their cationic forms and accumulated in isolated mitochondria or in mitochondria of living cells due to membrane potential negative inside.

Reduced forms of SkQR1, SkQBerb and SkQPalm inhibited lipid peroxidation in isolated mitochondria at nanomolar concentrations. In human fibroblasts SkQR1, SkQBerb and SkQPalm prevented fragmentation of mitochondria and apoptosis induced by hydrogen peroxide.

The novel cationic conjugates described here are promising candidates for drugs against various pathologies and aging as mitochondria-targeted antioxidants and selective mild uncouplers.

As a footnote I should remind folk that everyday antioxidant supplements do nothing for long-term health, and certainly don't end up in your mitochondria when you ingest them.

Source:
http://www.fightaging.org/archives/2012/10/broadening-study-of-mitochondrially-targeted-compounds.php

Gut Microbes in Aging

Microbes in the digestive system seem to have some influence on aging, insofar as they interact with the immune system, epigenetic regulation of nearby tissues, and so forth. In effect they act almost like an additional organ or biological system. Researchers are very much in the early stages of trying to understand how microbial life in the body fits in to the bigger picture of metabolism and aging - which is already very complex, and likely to become more so:

The ageing process affects the human gut microbiota phylogenetic composition and its interaction with the immune system. Age-related gut microbiota modifications are associated with immunosenescence and inflamm-ageing in a sort of self-sustaining loop, which allows the placement of gut microbiota unbalances among both the causes and the effects of the inflamm-ageing process.

Even if, up to now, the link between gut microbiota and the ageing process is only partially understood, the gut ecosystem shows the potential to become a promising target for strategies able to contribute to the health status of older people. In this context, the consumption of pro/prebiotics may be useful in both prevention and treatment of age-related pathophysiological conditions, such as recovery and promotion of immune functions ... Moreover, being involved in different mechanisms which concur in counteracting inflammation, such as down-regulation of inflammation-associated genes and improvement of colonic mucosa conditions, probiotics have the potentiality to be involved in the promotion of longevity.

Link: http://www.ncbi.nlm.nih.gov/pubmed/23079287

Source:
http://www.fightaging.org/archives/2012/10/gut-microbes-in-aging.php

The Cost of Smoking

There are numerous ways in which lifestyle choices can damage long-term health and lower life expectancy, but smoking remains one of the more effective, on a par with becoming obese:

The Life Span Study (LSS) was initiated in 1950 to investigate the effects of radiation, tracking over 100,000 people. However, most received minimal radiation exposure, and can therefore provide useful information about other risk factors. Surveys carried out later obtained smoking information for 68,000 men and women, who have now been followed for an average of 23 years to relate smoking habits to survival.

The younger a person was when they started smoking the higher the risk in later life. Older generations did not usually start to smoke until well into adult life, and usually smoked only a few cigarettes per day. In contrast, Japanese born more recently (1920-45) usually started to smoke in early adult life, much as smokers in Britain and the USA.

These differences in smoking habits are reflected in the mortality patterns. Smokers born before 1920 lost just a few years. In contrast, men born later (1920-45) who started to smoke before age 20 lost nearly a decade of life expectancy, and had more than double the death rate of lifelong non-smokers, suggesting that more than half of these smokers will eventually die from their habit. Results on the few women who had smoked since before age 20 were similar.

In addition to studying the risk of smoking, the researchers were able to examine the benefits of stopping. As elsewhere, those who stopped smoking before age 35 avoided almost all the excess risk among continuing smokers, and even those who stopped around age 40 avoided most of it.

Link: http://www.eurekalert.org/pub_releases/2012-10/bmj-st1102412.php

Source:
http://www.fightaging.org/archives/2012/10/the-cost-of-smoking.php

Metformin Still Dubious as a Calorie Restriction Memetic

One of the many ways in which FDA regulation corrupts research and development in medicine is the creation of a strong financial incentive to reuse existing drugs. It's much less expensive to obtain regulatory approval for a new marginal use of a drug already approved for other uses than it is to obtain regulatory approval for a completely new drug or other medical technology that might be far better. This discourages real progress in favor of something that only looks a little like progress: many of the existing stable of drugs are decades old, yet resources that might otherwise go to breaking new ground are instead poured into shoving these old square pegs into as many round holes as possible.

Given this it should be no great surprise to see that as work on the biology of calorie restriction has progressed, an increasing amount of time and money has been devoted to attempts to reuse existing drugs as calorie restriction mimetics - i.e. to find approved drugs that produce at least some of the same changes in metabolism, and with as few side-effects as possible. One of these drugs is metformin, but as I noted in a post earlier this year, it really isn't much to write home about, given that results from a range of studies are all over the map. It may or may not be useful or beneficial, and certainly doesn't show the clear benefits to health and life expectancy produced by calorie restriction itself:

Studies of the potential antiaging effects of antidiabetic biguanides, such as metformin, are still experimental for obvious reasons and their results are currently ambiguous.

Today I thought I'd direct your attention to a recent paper that shows metformin failing to do much for fly life spans:

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1.

We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis.

Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Nonetheless, money continues to flow for this and similar work.

Source:
http://www.fightaging.org/archives/2012/10/metformin-still-dubious-as-a-calorie-restriction-memetic.php

Reporting on the 2012 Singularity Summit

Videos of the presentations given at this year's Singularity Summit have yet to emerge online, but while we're waiting here is a report on the event:

Kurzweil took the stage on Saturday afternoon to deliver the summit's keynote address. "The singularity is near," he began quietly, a grin slowly spreading across his face. "No, it isn't here yet, but it's getting nearer," he said to laughs and applause. He spoke extemporaneously for over an hour, his presentation a mix of statistics, time series graphs, personal anecdotes, and predictions.

Computing ability and technological innovation have been increasing exponentially over the past few decades, he argued, alongside similar increases in life expectancy and income. "All progress stems from the law of accelerating returns," he proclaimed. He discussed his latest project - an attempt to reverse-engineer the human brain. "Intelligence is at the root of our greatest innovations: genetics, nanotechnology, and robotics. Once we master artificial intelligence, unimaginable new frontiers will open up."

After his talk, a man stood up and looked Kurzweil in the eye. "I'm in my 60s like you," he said, his voice faltering. "Do you think we'll make it?" It took me a few seconds to realize they were talking about immortality and I felt chills in that moment. "Life expectancy tables are based on what happened in the past," responded Kurzweil without skipping a beat. "In 25 years, we'll be able to add one year of life for every year that passes. We have a very good chance of making it through."

I should note that I believe Kurzweil's timelines for rejuvenation biotechnology are only possible if $300 million or more in dedicated research funding turns up at the SENS Foundation's front door tomorrow, thereby ensuring a good shot at demonstrating rejuvenation in old laboratory mice by the mid-2020s. As things stand progress towards the necessary technologies is far slower - not because it cannot be done, but because there is comparatively little interest in doing it, and therefore little funding.

One of the deep puzzles of our age is how a multi-billion-dollar "anti-aging" industry, full of enthusiasm but providing nothing that significantly impacts aging, can exist alongside the near absence of interest in funding research that will produce therapies capable of reversing the progression of aging. There are strange tides at work in the psychology surrounding aging and longevity.

Link: http://www.policymic.com/articles/16546/human-immortality-singularity-summit-looks-forward-to-the-day-that-humans-can-live-forever

Source:
http://www.fightaging.org/archives/2012/10/reporting-on-the-2012-singularity-summit.php

California Stem Cell Agency First: Big Pharma Hook Up


BURLINGAME, Ca. – For the first
time, a Big Pharma company has hooked into the $3 billion California
stem cell agency, a move that the agency described as a “watershed”
in its efforts to commercialize stem cell research.

The involvement of GlaxoSmithKline
comes via a partnership with ViaCyte, Inc., of San Diego, Ca., in a
clinical trial, partially financed with a $10.1 million grant today
from the stem cell agency. The trial involves a human embryonic stem
cell product that has “the potential to essentially cure patients
with type 1 diabetes and provide a powerful new treatment for those
with type 2 disease,” ViaCyte said. Scientific reviewers for the agency, formally known as the California Institute for Regenerative Medicine(CIRM),  “characterized the goal of the proposed therapy as as the 'holy grail' of diabetes treatments.”
CIRM Director Jeff Sheehy, who is co
vice chair of the agency's grant review group, said the ViaCyte product
could be manufactured on a large scale and basically involves “taking
(small) pouches and popping them into patients.”
The stem cell agency's award triggered
arrangements between ViaCyte and Glaxo that will bring in financial
and other support from Glaxo. The exact amount of cash was not
disclosed. CIRM said Glaxo will “co-fund and, assuming success,
conduct the pivotal trial and commercialize the product.” Under the terms of the grant, Glaxo and ViaCyte will have to meet CIRM milestones in order to secure continued funding. 
Following board approval, Jason
Gardner
, head of the Glaxo stem cell unit, characterized the
arrangement as a partnership. He told the board that the company
intends to develop a “sustainable pipeline.”
Gardner credited CIRM President Alan
Trounson
with being instrumental in helping to put the arrangement
together, beginning with their first meeting three years ago.
Trounson said the deal will resonate not only in California but
throughout the world.
Paul Laikind, president of ViaCyte,
also addressed the board, stressing the importance of CIRM's
financial support for his company over past years. It has received
$26.3 million (not including the latest grant) from California taxpayers at a time when stem cell
funding was nearly dried up. He noted that small companies such as ViaCyte do not have the resources to carry a product through the
final stages of clinical trials and subsequent production. Gardner also said,

“When the commercial funding avenues
have become much more risk averse, CIRM support (has ensured) that
promising, innovative cell therapy technologies are fully explored.”

In comments to the California Stem Cell
Report,
Elona Baum, CIRM's general counsel and vice president for
business development, described the award as a “watershed” for
the eight-year-old agency, linking the agency with Big Phama for the
first time. Much of CIRM's current efforts are aimed at stimulating
financial commitments from large companies, which are necessary to
commercialize stem cell research.
Arrangements between Big Pharma and
small companies are not unusual and can vanish quickly. However, the
CIRM-ViaCyte-Glaxo deal sends a message to other Big Pharma companies
and smaller ones, perhaps clearing away concerns that have hindered
other deals that could involve the stem cell agency.
The stem cell agency is pushing hard to
fulfill the promises of the 2004 ballot campaign that created CIRM.
Voters were led to believe that stem cell cures were virtually around
the corner. None have been developed to date.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/Jt1JalGURys/california-stem-cell-agency-first-big.html