Study Sheds Light on Bone Marrow Stem Cell Therapy for Pancreatic Recovery

Newswise LOS ANGELES (Oct. 2, 2012) Researchers at Cedars-Sinais Maxine Dunitz Neurosurgical Institute have found that a blood vessel-building gene boosts the ability of human bone marrow stem cells to sustain pancreatic recovery in a laboratory mouse model of insulin-dependent diabetes.

The findings, published in a PLoS ONE article of the Public Library of Science, offer new insights on mechanisms involved in regeneration of insulin-producing cells and provide new evidence that a diabetics own bone marrow one day may be a source of treatment.

Scientists began studying bone marrow-derived stem cells for pancreatic regeneration a decade ago. Recent studies involving several pancreas-related genes and delivery methods transplantation into the organ or injection into the blood have shown that bone marrow stem cell therapy could reverse or improve diabetes in some laboratory mice. But little has been known about how stem cells affect beta cells pancreas cells that produce insulin or how scientists could promote sustained beta cell renewal and insulin production.

When the Cedars-Sinai researchers modified bone marrow stem cells to express a certain gene (vascular endothelial growth factor, or VEGF), pancreatic recovery was sustained as mouse pancreases were able to generate new beta cells. The VEGF-modified stem cells promoted growth of needed blood vessels and supported activation of genes involved in insulin production. Bone marrow stem cells modified with a different gene, PDX1, which is important in the development and maintenance of beta cells, resulted in temporary but not sustained beta cell recovery.

Our study is the first to show that VEGF contributes to revascularization and recovery after pancreatic injury. It demonstrates the possible clinical benefits of using bone marrow-derived stem cells, modified to express that gene, for the treatment of insulin-dependent diabetes, said John S. Yu, MD, professor and vice chair of the Department of Neurosurgery at Cedars-Sinai, senior author of the journal article.

Diabetes was reversed in five of nine mice treated with the injection of VEGF-modified cells, and near-normal blood sugar levels were maintained through the remainder of the six-week study period. The other four mice survived and gained weight, suggesting treatment was beneficial even when it did not prompt complete reversal. Lab studies later confirmed that genetically-modified cells survived and grew in the pancreas and supported the repopulation of blood vessels and beta cells.

Anna Milanesi, MD, PhD, working in Yus lab as an endocrinology fellow, is the articles first author. The researchers cautioned that although this and other related studies help scientists gain a better understanding of the processes and pathways involved in pancreatic regeneration, more research is needed before human clinical trials can begin.

Insulin-dependent diabetes occurs when beta cells of the pancreas fail to produce insulin, a hormone that regulates sugar in the blood. Patients must take insulin injections or consider transplantation of a whole pancreas or parts of the pancreas that make insulin, but transplantation carries the risk of cell rejection.

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PLoS ONE: Beta-cell Regeneration Mediated by Human Bone Marrow Mesenchymal Stem Cells.

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New stem cell research could bring choices to heart patients

Contributed photo

Dr. Nabil Dib

They're called "no-option patients."

They've endured angioplasty, stent procedures, bypasses and a long line of medications. None of the treatments has fixed the plaque-plugged coronary arteries that trigger angina, starve the heart of blood and force people to hunch in pain after walking twoblocks.

Adult stem cell research at an Oxnard hospital is aimed at giving themchoices.

"A patient who has no hope will have some hope," said Dr. Nabil Dib, a world-renowned researcher partnering with St. John's Regional Medical Center. "It's a hope for potential therapy that will revise the way we treat cardiovasculardisease."

Stem cells are blank cells that function as the body's building blocks. They are able to grow into many different kinds of cells, including blood, muscle and tissue. Dib's work involves adult stem cells harvested from his patients, as opposed to stem cells that come from embryos and trigger ethicaldebates.

In a clinical trial starting at St. John's and 49 other hospitals across the country, the adult stem cells will be isolated and used to create new blood vessels. It's a way of manipulating the body into building new pathways for blood flow impeded by barricadedarteries.

"We're doing like a bypass a biological bypass," Dibsaid.

The trial is part of a genre of research aimed at using the body's own resources to repair the heart. It could reduce consequences ranging from heart transplants and hospitalizations to heart failure anddeath.

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New stem cell research could bring choices to heart patients

Sofia University Highlights Community Art Exhibit as Part of Inauguration Events

Acclaimed poet, performing artist and Womens Spirituality professor Judy Grahn to headline Performing Arts segment

Palo Alto, CA (PRWEB) October 03, 2012

Judy Grahn is an internationally acclaimed poet, writer, social theorist and LGBTQ activist, as well as professor and program chair of the Womens Spirituality program at Sofia University. Her work, which includes, "Edward the Dyke and Other Poems" and "Blood, Bread, and Roses: How Menstruation Created the World" underpins several movements including gay, lesbian and queer; feminist/woman-centered; and womens spirituality. Grahn also collaborates with other artists such as singer-songwriter Anne Carol Mitchell and dancer and choreographer Anne Blethenthal. She has been a recipient of the Lambda Literary Award, American Book Award, American Library Award and Founding Foremothers of Womens Spirituality Award.

The theme of the Community Art Exhibit will be diversity in all forms. Artwork submitted by Sofia University students, staff, faculty, alumni, and other members of the community will be on display and the public is invited to attend. Artwork will include visual art (sculpture, paintings, drawings, photography, mixed media) and performing art such as music and dance. The Community Art Exhibit is part of a series of events open to the public over a three-day period. Inauguration events will start on Wednesday, October 17th and lead up to the official Inauguration Ceremony on Friday, October 19th.

Neal King, Ph.D., is the first president of Sofia University. King also currently serves as President of the International Association of University Presidents (IAUP) and is a founding member of LGBTQ Presidents in Higher Education. He also serves on the Executive Board of California Campus Compact.

For a full schedule of inauguration events and times, please visit: http://www.sofia.edu/inauguration

About Sofia University

Founded in 1975, Sofia University (formerly the Institute of Transpersonal Psychology) is a private, non-sectarian university accredited by the Western Association of Schools and Colleges. For over 35 years, within the context of scholarship and research, the school has offered transformative education for the whole person, probing the mind, body, spirit connection. As Sofia University, the school is broadening its mission, reaching into multiple disciplines and adding undergraduate study. For more information, visit http://www.sofia.edu.

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Kristen Sato Sofia University (650) 493-4430 249 Email Information

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Sofia University Highlights Community Art Exhibit as Part of Inauguration Events

1st Year-Long Space Station Mission May Launch in 2015: Reports

The first 12-month mission to the International Space Station may launch in 2015, according to Russian media reports.

Under the plan, two astronauts one Russian and one American would blast off in March 2015 on an experimental endurance mission that's twice as long as current space station stays, officials with Russia's Federal Space Agency (known as Roscosmos) said Tuesday (Oct. 3).

"The principal decision has been made, and we just have to coordinate the formalities," said Alexei Krasnov, head of manned space missions at Roscosmos, according to Russian news agency Ria Novosti. "If the mission proves to be effective, we will discuss sending year-long missions to ISS on a permanent basis."

Krasnov added that the space station's partner agencies have already devised a scientific program for the long-duration mission, Ria Novosti reported. [Most Extreme Human Spaceflight Records]

Krasnov did not name the two astronauts who will launch on the marathon mission in the Ria Novosti report. Russia's Interfax news agency reported in August, however, that the NASA crewmember will likely be Peggy Whitson, who stepped down recently as the agency's chief astronaut in order to rejoin its active spaceflying ranks.

Would You Sign Up for a Years-Long Space Mission?

A year-long stay aboard the orbiting lab could help lay the groundwork for manned missions beyond low-Earth orbit, by allowing scientists to study how long-term spaceflight affects the human body.

That objective may be of great interest to NASA, which is currently working to send astronauts to destinations in deep space. In 2010, President Barack Obama directed the agency to get people to a near-Earth asteroid by 2025, then on to the vicinity of Mars by the mid-2030s.

According to some mission concepts, a manned roundtrip journey to Mars would take about two years to complete.

While nobody has yet resided aboard the International Space Station for a complete year, such a long orbital stay is not unprecedented. Cosmonaut Valery Polyakov, a medical doctor, lived aboard Russia's Mir space station for 438 consecutive days during a mission that began in January 1994 and ended in March 1995.

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1st Year-Long Space Station Mission May Launch in 2015: Reports

Space station in no need to move to avoid debris

MOSCOW (AP) Russia's Mission Control Center said Wednesday it dropped an earlier plan to move the International Space Station into a different orbit to avoid possible collision with space debris after additional calculations showed that there was no such threat.

Mission Control Center said in a statement carried by Russian news agencies that a fragment of space debris would fly by too far to pose any danger to the space outpost, so a plan to fire booster rockets to carry out the maneuver on Thursday at 07:22 a.m. Moscow time (0322 GMT) was canceled.

The space station performs evasive maneuvers when the likelihood of a collision exceeds one in 10,000.

NASA estimates that more than 21,000 fragments of orbital debris larger than 10 centimeters (3.9 inches) are stuck in earth's orbit, and experts worry that orbiting junk is becoming a growing problem for the space industry.

There are six astronauts three Russians, two Americans and one from Japan onboard the orbiting laboratory.

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Space station in no need to move to avoid debris

Space Tourist Outbids NASA for Flight

What's a rich space tourist to do? If you want to fly in space, seats are harder to find than a flight out of Chicago's O'Hare airport during a blizzard. So your only option is to bump an astronaut from a seat on a Russian Soyuz spacecraft going to the International Space Station.

ABC News has learned that singer Sarah Brightman, of "Phantom of the Opera" fame, will be the next tourist in space, sometime in 2014 or 2015. To get her seat she had to pay the Russian space agency more than the $51 million NASA budgets on average to send its astronauts to the station.

To maintain its presence in orbit when Soyuz seats are limited, NASA had to agree to commit at least one of its astronauts to spend a year in space, instead of the six months they currently stay. Brightman's trip will be announced in Moscow on Oct. 10.

NASA says a year in space has great medical research benefits. Astronauts spending just six months on the space station in the past have suffered from radiation exposure, muscle mass loss, decreased bone density, and vision problems. The research from a year on the space station will help NASA plan for long flights to Mars or an asteroid. It does mean an astronaut will get booted from a flight to adjust for one less seat.

When the space shuttle quit flying last year, it created a conundrum for companies like Space Adventures, whose business -- sending rich tourists into space -- depended upon the resources of Roscosmos, the Russian space agency. Roscosmos is the only space agency willing to send tourists to space. NASA won't do it, and now they don't have a spacecraft anyway so it's a moot point.

Don't have $50 million to spare? There is a budget option: $200,000 for a suborbital flight on Virgin Galactic' s SpaceshipTwo, which should start commercial flights in a couple of years. SpaceShipTwo is designed to be a six-passenger, two-pilot craft, flying to the edge of space. The flight will be short -- just six minutes of weightlessness, but passengers will be able to unbuckle and float around the cabin. If you have $1 million to spare, you can book one trip for yourself and a few friends.

Boeing would like to get into the space tourism business as well, partnering with Space Adventures at some point to launch from Florida.

Space Adventures offers ten days on the International Space Station, in low Earth orbit, with great views and not-so-great accommodations. But there is zero gravity, which means you get to do somersaults and float as much as you want. For a singer like Sarah Brightman, who thrilled the world when she starred in "Phantom of the Opera," the inspiration should be out of this world.

Rumors flew earlier this week when author J.K. Rowling told an audience in England she had once been offered a seat on a space shuttle for a couple of million dollars. NASA quickly scotched that story.

Space Adventures has flown seven tourists into space since 2001. Clients have paid from $22 million to $35 million in the past, but the limited number of Soyuz seats drove the price to more than $50 million. After all, if NASA is willing to pay $51 million, Russia doesn't need to sell the seat at half price.

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Space Tourist Outbids NASA for Flight

Men shaved bald perceived to be better leaders

Chrome domes, take note: New research from one of the premier business schools in the U.S. suggests men who shave their heads are perceived to be more dominant, more athletic and better leaders.

Research by information management lecturer Albert Mannes at the University of Pennsylvania's Wharton School of Business suggests that while men with male-pattern baldness tend to view themselve as having poor self-esteem, those who take the pre-emptive step of shaving a thinning head of hair enjoy numerous benefits in terms of how they are perceived by others.

In the paper, published in the journal Social Psychological and Personality Science, Mannes outlines the results of three recent experiments involving men with shorn heads:

Two of the experiments showed that shaved men were perceived as being as much as an inch taller, on average, and stronger: the survey showed shaved men were estimated to be able to bench press 13 per cent more, on average.

In all three, they were also perceived to have better leadership qualities.

Mannes, who has shaved his head since he started going bald in his thirties, said the idea for the experiments came from his own experience.

"After fighting it for a while, one day I just decided to shave it off," he said in an interview published on the Wharton school's website.

While he received positive reviews from those who knew him, he noticed that new interactions with strangers were different. Others seemed "stand-offish and even deferential" to him, where they hadn't been before.

The experiments also showed a downside, however.

Men with shaved heads were rated lower in attractiveness and also seen as being older. But they nonetheless scored higher than men with thinning hair, who were ranked lower in almost all categories.

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Men shaved bald perceived to be better leaders

NASA Tournament Lab & TopCoder Launch Big Data Challenge Series for U.S. Government Agencies

ORLANDO, Fla., Oct. 3, 2012 /PRNewswire/ --TopCoder, Inc., the world's largest competitive Community of digital creators today announced the launch of the Big Data Challenge a series of ideation competitions hosted through the NASA Tournament Lab (NTL) to create mobile applications that integrate across multiple United States agencies data repositories related to the field of health, energy and earth sciences. Competitors will be tasked with imagining tools and techniques that find new value hidden in discrete government information domains and then describing how they may be shared as universal, cross-agency solutions that transcend the limitations of individual silos. Registration is open today through 10/13/2012 for the Ideation Challenge phase, the first of four idea generation competitions in the series. For full competition details and registration visit: http://community.topcoder.com/coeci/nitrd

(Logo: http://photos.prnewswire.com/prnh/20080820/NYW078LOGO )

Sponsored by the Networking and Information Technology Research and Development program, (NITRD), the Big Data Challenge series is a partnership between NASA, the National Science Foundation (NSF), the Department of Energy (DoE), TopCoder and Harvard Business School. The goal of the series is to apply the process of Open Innovation (OI) to conceptualizing novel approaches to extracting value from the huge information sets residing in various agency silos and delivering impactful value while remaining consistent with individual agency missions.

The opportunity to contribute to a matter of national importance draws many individuals and teams from diverse fields within the general public, so beyond cash prizes are the rewards of peer recognition and the satisfaction that comes with making a real impact on a significant challenge.

The TopCoder Open Innovation platform and process allows U.S. government agencies to conduct high risk/high reward challenges in an open and transparent environment with predictable cost, measurable outcomes-based results and the potential to move quickly into unanticipated directions and new areas of software technology. Big data is a term applied to data sets whose size is beyond the ability of commonly used software tools to capture, manage and process the data within a tolerable elapsed time. Big data sizes are a constantly moving target currently ranging from a few dozen terabytes to many petabytes of data in a single data set.

"The TopCoder platform for Open Innovation is the most sophisticated platform of its kind available today in the digital space," said Rob Hughes, President and COO of TopCoder, Inc. "Matched with the power and talent of the TopCoder Community, we look forward to seeing new value created out of existing government big data that will manifest itself in new tools and services for both American consumers and industry."

The TopCoder platform supports the entire end-to-end digital creation lifecycle from idea conception to implementation and support through a true collaborative open innovation model. Almost any type of content, application, algorithm or digital asset can be built entirely through the platform whether a standalone mobile app through to enhancements or additions to large, existing enterprise systems to the development of entirely new cloud based offerings for customers to testing and support through small enhancements and bug fixes. All areas of digital creation are covered through one easy to use cloud based Innovation as a Platform (IaaP) offering accessing TopCoder's renowned community of over 425,000 members from business analysis to creative asset creation, analytics and sophisticated processes for API, software design and development as well as digital content.

About NASA Tournament Lab NASA and Harvard University have established the NASA Tournament Lab (NTL), which with the enabling capabilities of the TopCoder community allow for competitions to create the most innovative, most efficient, and most optimized solutions for specific, real-world challenges being faced by NASA researchers. The NTL provides an online virtual facility for NASA researchers with a computational or complex data processing challenge to "order" a solution, just like they would order laboratory tests or supplies. Learn more at the official NTL Website.

About NITRD The Networking and Information Technology Research and Development (NITRD) Program is the Nation's primary source of Federally funded revolutionary breakthroughs in advanced information technologies such as computing, networking, and software. A unique collaboration of Federal research and development agencies, the NITRD Program seeks to:

The NITRD Program stems from the High-Performance Computing (HPC) Act of 1991 (Public Law 102-194) as amended by the Next Generation Internet Research Act of 1998 (Public Law 105-305). These laws authorize Federal agencies to set goals, prioritize their investments, and coordinate their activities in networking and information technology research and development.

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NASA Tournament Lab & TopCoder Launch Big Data Challenge Series for U.S. Government Agencies

NASA's Radiation Belt Storm Probes record electromagnetic "Earthsong"

NASAs twin Radiation Belt Storm Probes (RBSP) took a musical interlude and listened to the Earth singing to itself. This Earthsong, as NASA calls it, was recorded by the two spacecraft as they orbited inside the highly radioactive Van Allen Belts that surround the Earth. The song is in the form of radio waves generated by the belts and the study of it may provide a clue toward answering the question of how to protect satellites and astronauts from deadly radiation storms.

The Earthsong is better known to ham radio operators as the chorus. They've been listening to it from the ground for years and its rising and falling tones sound like a dawn chorus of chirping birds, from which it derives its name.

"This is what the radiation belts would sound like to a human being if we had radio antennas for ears," said Craig Kletzing of the University of Iowa, whose team built the RBSPs Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) receivers used to pick up the signals.

The chorus isn't acoustic, but rather electromagnetic in nature. Its made up of radio waves in the 0 to 10 kHz range and is caused by intense plasma waves, called chorus waves, in the Van Allen Belt. However, they are more than just a pretty sound. One of the most important waves in the Van Allen Belts, they may be the cause of killer electrons electrons that are caught up in the chorus wave and boosted to a high enough energy to damage electronic equipment or even astronauts.

This fits in very well with the brief of the Radiation Belt Storm Probes. Theyre designed to detect these waves by means of the EMFISIS antennae, which are tuned to detect very low frequency (VLF) emissions. The transmissions they send back are 16-bit, which is the same quality as a CD. Furthermore, with these two spacecraft, stereo is possible. That isn't just to make the music sound richer, it also helps to build up a complete picture of the phenomenon, where exactly it occurs and how.

Launched August 30, 2012, the RBSPs mission is to study the highly radioactive Van Allen Belts and the part they play in space weather. This goes beyond pure science because severe space weather, such as a massive solar flare could imperil astronauts or even threaten to knock out the power grid on half the Earth in an instant. Given that the chorus wave may contribute to such severe events, it may be that the Earthsong is more like the song of the mythical Sirens that were a prelude to disaster.

An MP3 recording of the Earthsong is available here.

The NASA video below discusses the chorus wave.

Source: NASA

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NASA's Radiation Belt Storm Probes record electromagnetic "Earthsong"

NASA's infrared observatory measures expansion of universe

ScienceDaily (Oct. 3, 2012) Astronomers using NASA's Spitzer Space Telescope have announced the most precise measurement yet of the Hubble constant, or the rate at which our universe is stretching apart.

The Hubble constant is named after the astronomer Edwin P. Hubble, who astonished the world in the 1920s by confirming our universe has been expanding since it exploded into being 13.7 billion years ago. In the late 1990s, astronomers discovered the expansion is accelerating, or speeding up over time. Determining the expansion rate is critical for understanding the age and size of the universe.

Unlike NASA's Hubble Space Telescope, which views the cosmos in visible light, Spitzer took advantage of long-wavelength infrared light to make its new measurement. It improves by a factor of 3 on a similar, seminal study from the Hubble telescope and brings the uncertainty down to 3 percent, a giant leap in accuracy for cosmological measurements. The newly refined value for the Hubble constant is 74.3 plus or minus 2.1 kilometers per second per megaparsec. A megaparsec is roughly 3 million light-years.

"Spitzer is yet again doing science beyond what it was designed to do," said project scientist Michael Werner at NASA's Jet Propulsion Laboratory in Pasadena, Calif. Werner has worked on the mission since its early concept phase more than 30 years ago. "First, Spitzer surprised us with its pioneering ability to study exoplanet atmospheres," said Werner, "and now, in the mission's later years, it has become a valuable cosmology tool."

In addition, the findings were combined with published data from NASA's Wilkinson Microwave Anisotropy Probe to obtain an independent measurement of dark energy, one of the greatest mysteries of our cosmos. Dark energy is thought to be winning a battle against gravity, pulling the fabric of the universe apart. Research based on this acceleration garnered researchers the 2011 Nobel Prize in physics.

"This is a huge puzzle," said the lead author of the new study, Wendy Freedman of the Observatories of the Carnegie Institution for Science in Pasadena. "It's exciting that we were able to use Spitzer to tackle fundamental problems in cosmology: the precise rate at which the universe is expanding at the current time, as well as measuring the amount of dark energy in the universe from another angle." Freedman led the groundbreaking Hubble Space Telescope study that earlier had measured the Hubble constant.

Glenn Wahlgren, Spitzer program scientist at NASA Headquarters in Washington, said infrared vision, which sees through dust to provide better views of variable stars called cepheids, enabled Spitzer to improve on past measurements of the Hubble constant.

"These pulsating stars are vital rungs in what astronomers call the cosmic distance ladder: a set of objects with known distances that, when combined with the speeds at which the objects are moving away from us, reveal the expansion rate of the universe," said Wahlgren.

Cepheids are crucial to the calculations because their distances from Earth can be measured readily. In 1908, Henrietta Leavitt discovered these stars pulse at a rate directly related to their intrinsic brightness.

To visualize why this is important, imagine someone walking away from you while carrying a candle. The farther the candle traveled, the more it would dim. Its apparent brightness would reveal the distance. The same principle applies to cepheids, standard candles in our cosmos. By measuring how bright they appear on the sky, and comparing this to their known brightness as if they were close up, astronomers can calculate their distance from Earth.

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NASA considering deep-space station on moon

There appears to be support within NASA to position astronauts at an Earth-moon libration point to bolster the space agency's plans of pushing beyond low-Earth orbit with its Orion spacecraft design.

Anchoring hardware and a crew at the Earth-moon L2 "gateway" would offer many benefits, advocates say. One of them is building on multinational cooperation honed at the International Space Station (ISS).

Under review is use of Russian-supplied hardware at the L2 point, according to insiders contacted by SPACE.com. Surplus space shuttle gear and ISS-flight-ready spares are also in the mix.

Regarding the use of Russian space hardware, both the Multipurpose Laboratory Module and the Scientific-Power Module are new modules being developed in Russia. Both will add new capabilities to the ISS. A proposal on the table seeks to use a similar Russian-provided Scientific-Power Module in cislunar space as a base of operations for exploration missions. [Gallery: Visions of Deep-Space Station Missions]

NASA space planners have been sketching out an exploration strategy that would make use of the Lagrange points. For one, by exploring and working beyond the Earth's radiation belts, more can be learned about space radiation protection. Additionally, the Lagrange points provide unique perspectives of the moon, sun and Earth. Sojourns to the Earth-moon L2 would take humans farther than they have ever been from Earth.

Done deal?

A recent Orlando Sentinel newspaper story kick-started the perception that NASA officials have picked a leading candidate for the agency's next major mission: creation of a "gateway spacecraft" parked at the Earth-moon libration point 2, also known as EML-2.

Indeed, NASA has spotlighted the fact that, as crewed missions extend farther from Earth and for longer periods of time, they will require new capabilities to enable safe and sustainable habitation and exploration.

As reported by SPACE.com earlier this year, a Feb. 3 memo from William Gerstenmaier, NASA's associate administrator for human exploration and operations, noted that a team would be formed to develop a cohesive plan for exploring the EML-2 spot in space.

Libration points, also known as Lagrangian points, are places in space where the combined gravitational pull of two large masses roughly balance each other out, allowing spacecraft to essentially "park" there.

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NASA airborne radar to study volcanoes in Alaska and Japan

ScienceDaily (Oct. 3, 2012) NASA scientists periodically monitor subtle changes in volcanic activity with the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) carried by a modified NASA C-20A (G-III) aircraft. This month the specialized NASA Airborne Science aircraft, with the UAVSAR installed in a pod under the plane's fuselage, deploys to Alaska and Japan to continue a study of active volcanoes.

Developed by NASA's Jet Propulsion Laboratory in Pasadena, Calif., the UAVSAR uses a technique called interferometry to detect and measure very subtle deformations in Earth's surface.

This study builds on UAVSAR research of U.S. West Coast and Hawaiian volcanoes acquired from 2009 through 2011 and additional observations of Central and South American volcanoes gathered in 2010 and 2011.

The deployment of NASA's C-20A (G-III) began Oct. 2 when the aircraft departed NASA's Dryden Aircraft Operations Facility in Palmdale, Calif., imaging volcanoes in the Western United States en route to Joint Base Lewis-McChord in Tacoma, Wash. After refueling, the aircraft will travel on to Joint Base Elmendorf-Richardson near Anchorage, Alaska.

The sensor will image volcanoes in Alaska, including those in the Aleutian Islands, before arriving at Yokota Air Force Base near Tokyo, Japan. Yokota is the staging location for science missions to collect data about volcanoes on several islands in Japan that pose a hazard to nearby populations. On its return, the aircraft will repeat the route, acquiring data from the opposite viewing direction, before arriving back at its base in Palmdale Oct. 11.

The aircraft features a high-precision autopilot designed and developed by engineers at NASA's Dryden Flight Research Center. The Precision Platform Autopilot guides the aircraft using a kinematic differential Global Positioning System developed by JPL and the aircraft's inertial navigation system to enable it to fly repeat paths to an accuracy of 15 feet or less. With the precision autopilot engaged, the synthetic aperture radar is able to acquire repeat-pass data that can measure land-surface changes within millimeters.

UAVSAR provides a measurement system that complements satellite-based observations by providing rapid revisits and imaging of active volcanoes to better understand their deformation prior to, during or after an eruption.

In addition to the NASA study of volcanoes, the UAVSAR team is working with Japan Aerospace Exploration Agency scientists to define cross-calibration sites, including flight lines over disaster and forested areas, between the UAVSAR and the PISAR-L2 airborne radars.

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NASA airborne radar to study volcanoes in Alaska and Japan

NASA's Curiosity Rover Checks-In on Mars Using Foursquare

NASA's Curiosity Mars rover checked in on Mars Wednesday using the mobile application Foursquare. This marks the first check-in on another planet. Users on Foursquare can keep up with Curiosity as the rover checks in at key locations and posts photos and tips, all while exploring the Red Planet.

"NASA is using Foursquare as a tool to share the rover's new locations while exploring Mars," said David Weaver, associate administrator for communications at NASA Headquarters in Washington. "This will help to involve the public with the mission and give them a sense of the rover's travels through Gale Crater."

After landing in Gale Crater last month, Curiosity began a planned 23-month mission that includes some of Mars' most intriguing scientific destinations. Curiosity is roving toward Mount Sharp, a mountain about 3 miles (5 kilometers) tall. The rover is conducting experiments along the way, seeking clues in the rocks and soil that would indicate whether Mars ever was capable of supporting microbial life. It is taking and sharing pictures of the trip.

Back here on Earth, Foursquare users will be able to earn a Curiosity-themed badge on the social media platform for check-ins at locations that generate an interest in science, technology, engineering and mathematics. Available late this year, this new badge will encourage Foursquare users to explore science centers, laboratories and museums that pique scientific curiosity.

NASA has been on Foursquare since 2010 through a strategic partnership with the platform. This partnership, launched with astronaut Doug Wheelock's first-ever check-in from the International Space Station, has allowed users to connect with NASA and enabled them to explore the universe and re-discover Earth.

The partnership launched the NASA Explorer badge for Foursquare users, encouraging them to explore NASA-related locations across the country. It also included the launch of a NASA Foursquare page, where the agency provides official tips and information about the nation's space program.

The Jet Propulsion Laboratory (JPL) manages the Mars Science Laboratory mission and its Curiosity rover for NASA's Science Mission Directorate in Washington. The rover was designed, developed and assembled at JPL, a division of the California Institute of Technology in Pasadena, Calif.

To find out more about Mars Curiosity and NASA on Foursquare, visit: http://www.foursquare.com/MarsCuriosity and http://www.foursquare.com/NASA

For information about NASA's partnership with Foursquare, visit: http://www.nasa.gov/connect/foursquare.html

For more information about NASA's Curiosity mission, visit: http://www.nasa.gov/msl and http://mars.jpl.nasa.gov/msl

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NASA's Curiosity Rover Checks-In on Mars Using Foursquare

NASA rover checks in online from Mars

NASA's Mars rover took the post-PC revolution into space on Wednesday by using location-sharing mobile application Foursquare to "check-in" on the Red Planet.

"NASA is using Foursquare as a tool to share the rover's new locations while exploring Mars," said NASA spokesman David Weaver.

"This will help to involve the public with the mission and give them a sense of the rover's travels through Gale Crater," where the Curiosity rover landed in August.

People using social network Foursquare can keep up with Curiosity as the rover explores Mars, checking in at key locations and posting photos and tips, according to NASA.

Details were available online at foursquare.com/MarsCuriosity or foursquare.com/NASA.

NASA announced last week that the Mars rover has discovered gravel once carried by the waters of an ancient stream that "ran vigorously" through the area.

Scientists had previously found other evidence that water once was present on the Red Planet, but this is the first time stream bed gravel has been discovered.

Curiosity is on a two-year mission to investigate whether it is possible to live on Mars and to learn whether conditions there might have been able to support life in the past.

The $2.5 billion craft landed in Gale Crater on August 6, opening a new chapter in the history of interplanetary exploration.

Earth-bound Foursquare users will be able to earn Curiosity-themed virtual badges at the social network for check-ins at labs, science centers or other locations that inspire interest in technology, math or engineering.

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NASA rover checks in online from Mars

Singer Sarah Brightman Outbids NASA for Space Tourist's Seat

What's a rich space tourist to do? If you want to fly in space, seats are harder to find than a flight out of Chicago's O'Hare airport during a blizzard. So your only option is to bump an astronaut from a seat on a Russian Soyuz spacecraft going to the International Space Station.

ABC News has learned that singer Sarah Brightman, of "Phantom of the Opera" fame, will be the next tourist in space, sometime in 2014 or 2015. To get her seat she had to pay the Russian space agency more than the $51 million NASA budgets on average to send its astronauts to the station.

To maintain its presence in orbit when Soyuz seats are limited, NASA had to agree to commit at least one of its astronauts to spend a year in space, instead of the six months they currently stay. Brightman's trip will be announced in Moscow on Oct. 10.

NASA says a year in space has great medical research benefits. Astronauts spending just six months on the space station in the past have suffered from radiation exposure, muscle mass loss, decreased bone density, and vision problems. The research from a year on the space station will help NASA plan for long flights to Mars or an asteroid. It does mean an astronaut will get booted from a flight to adjust for one less seat.

When the space shuttle quit flying last year, it created a conundrum for companies like Space Adventures, whose business -- sending rich tourists into space -- depended upon the resources of Roscosmos, the Russian space agency. Roscosmos is the only space agency willing to send tourists to space. NASA won't do it, and now they don't have a spacecraft anyway so it's a moot point.

Don't have $50 million to spare? There is a budget option: $200,000 for a suborbital flight on Virgin Galactic' s SpaceshipTwo, which should start commercial flights in a couple of years. SpaceShipTwo is designed to be a six-passenger, two-pilot craft, flying to the edge of space. The flight will be short -- just six minutes of weightlessness, but passengers will be able to unbuckle and float around the cabin. If you have $1 million to spare, you can book one trip for yourself and a few friends.

Boeing would like to get into the space tourism business as well, partnering with Space Adventures at some point to launch from Florida.

Space Adventures offers ten days on the International Space Station, in low Earth orbit, with great views and not-so-great accommodations. But there is zero gravity, which means you get to do somersaults and float as much as you want. For a singer like Sarah Brightman, who thrilled the world when she starred in "Phantom of the Opera," the inspiration should be out of this world.

Rumors flew earlier this week when author J.K. Rowling told an audience in England she had once been offered a seat on a space shuttle for a couple of million dollars. NASA quickly scotched that story.

Space Adventures has flown seven tourists into space since 2000. Clients have paid from $22 million to $35 million in the past, but the limited number of Soyuz seats drove the price to more than $50 million. After all, if NASA is willing to pay $51 million, Russia doesn't need to sell the seat at half price.

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Singer Sarah Brightman Outbids NASA for Space Tourist's Seat

Scientists Invited To Submit Proposals For Biological Research In Space

October 3, 2012

Image Caption: Japan Aerospace Exploration Agency astronaut Aki Hoshide, Expedition 33 flight engineer, services the Nano Step payload in the Kibo laboratory of the International Space Station. Credit: NASA

Lee Rannals for redOrbit.com Your Universe Online

NASA announced it is inviting scientists from all over the world to submit proposals to perform biological research aboard the International Space Station.

NASAs Research Opportunities in Space Biology opened up for proposals on Sunday, challenging scientists to submit their experiments that could provide answers to questions about how life adapts and responds to microgravity.

Investigators will have the opportunity to take advantage of new cell, plant and animal research facilities being developed for the space station.

NASA said proposals submitted by the scientists should demonstrate benefits to astronauts living and working in the harsh environment of space during long-duration missions. The space agency also said they should improve medicine and health care for humans on Earth as well.

NASAs Research Announcement (NRA) focuses on ground-based research designed to lead to new space biology investigations aboard the space station.

The space agency said the investigations should use microgravity and other characteristics of the space environment effectively to enhance our understanding of basic biological processes and develop the scientific and technological foundations for a safe, productive human presence in space.

The investigations should also be able to be applied to help improve the United States competitiveness, education and quality of life, according to NASA.

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Scientists Invited To Submit Proposals For Biological Research In Space

Genia Technologies Collaborates with Professors Jingyue Ju at Columbia and George Church at Harvard to Develop a …

MOUNTAIN VIEW, Calif., Oct. 3, 2012 /PRNewswire/ -- Genia Technologies, Inc. today announced a collaboration with investigators at Columbia University and Harvard University to develop a nanopore-based sequencing system that will accelerate the use of DNA sequencing in the clinic. The three-way collaboration focuses on the development of a single molecule sequencing system combining Genia's standard complementary metal-oxide semiconductor (CMOS) integrated circuit, Professor George Church's novel protein constructs with Columbia's unique Tag-based sequencing chemistry approach. Genia has recently entered into an exclusive license agreement with Columbia University for use of its Tag-based sequencing technology. By combining standard protein nanopores with the tag sequencing chemistry (NanoTag) and semiconductor technology, the Genia chip will be more accurate, faster, and affordable than current commercially available technologies. This integrated circuit platform is designed for decentralized deployment, ease of use, and less upfront sample preparation, at a size and price ideal for diagnostics in the clinical setting.

"We believe DNA sequencing will dominate molecular diagnostics in the future," said Stefan Roever, CEO of Genia. "We have been working to fully operationalize a nanopore-based sequencing approach, and this chemistry will be the catalyst that helps us finally bring affordable, easy-to-use genomic diagnostics into everyday medical care."

"The Genia platform combines the single molecule detection capabilities seen in nanopore-based platforms with true semiconductor scalability," Roever continued. "We are thrilled to collaborate with Professor Jingyue Ju, Professor George Church, and their teams to develop the NanoTag sequencing chemistry on our platform and believe this Tag-based approach overcomes the inherent accuracy issues you have with trying to pull native DNA through the pore. We believe this will be the winning chemistry for nanopore-based sequencing."

This transformational platform, based on the innovative electronic Nano-SBS system developed by Dr. Ju and his team at Columbia's Engineering School in an academic collaboration with Dr. John Kasianowicz and his group at the National Institute of Standards and Technology, uses a robust sequencing-by-synthesis approach to determine DNA sequences electronically at the single molecule level, without requiring amplification or optical detection. The technology identifies DNA sequences not by detecting the nucleotides themselves with the nanopore, but by measuring the current changes caused by the passage of each of four different tags that are released from the incorporated nucleotide during the polymerase reaction. On September 21, 2012, Dr. Ju, Dr. Kasianowicz, and their groups published an article in the peer-reviewed journal, Scientific Reports (Nature Publication group), "PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis" (2, 684;DOI:10.1038/srep00684), that successfully demonstrates proof of principle of the Nano-SBS system.

"We are very fortunate to have partnered with Genia Technologies. We are very impressed with their chip capabilities and are excited to work with them and take our novel tag sequencing chemistry to commercialization. Our published research with Dr. Kasianowicz represents the first step in further development of this novel sequencing technology. By scaling with a nanopore integrated circuit, the commercial implications and the impact on biomedical research and clinical diagnostics are very exciting," said Dr. Ju, Professor of Chemical Engineering and Pharmacology at Columbia University.

Genia's technology combines a nanopore array integrated on a standard CMOS chip. Software on the chip controls the insertion of the nanopores into the lipid bilayers and allows for active control of individual sensors on the array. Genia has strong IP around their analog electronic circuitry, which at the heart, controls each sensor of the array and allows for operationalizing the overall nanopore-based platform. In addition, Genia's patented protein construct and methodology solve the diffusion, capture rate, and translocation speed issues faced by alternative exonuclease-based approaches.

To make NanoTag sequencing a reality, a fusion protein is needed to position the polymerase near the nanopore's vestibule, so that the tags can be easily captured and detected in the barrel of the pore. As part of the Genia collaboration, George Church and his group will provide the protein constructs which are integral to the overall Tag-based approach.

"DNA sequencing is the future of molecular diagnostics and finding a platform that can be deployed straight into the clinic and enable rapid, easy to interpret results will be the way to truly achieve personal genomes worthy of precision medicine," said George Church, Professor of Genetics, at Harvard University. "The Genia integrated circuit combined with the NanoTag sequencing chemistry, seems to have a winning formula that makes it ideal for clinical care and may be the platform that finally moves DNA sequencing into the doctor's office to ensure earlier diagnostics, treatment, and better patient outcomes.

The first version of Genia's CMOS chip is in-house and is currently being used to further develop and test the NanoTag sequencing chemistry. The company expects to ship its first devices to customers for beta testing by the end of 2013 and expects to have a commercial product, on the market in 2014.

About Genia Technologies:

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Genia Technologies Collaborates with Professors Jingyue Ju at Columbia and George Church at Harvard to Develop a ...

Hardide appoints a Business Development Manager

LONDON (ShareCast) - Hardide Coatings, a surface engineering technology company, has reported a rise in its turnover in the oil and gas sector by 40 per cent in the past 12 months.

In order to further develop sales in the sector, the company has appointed Martin Wainwright as the dedicated Business Development Manager, whose role will be to increase sales of Hardide (Munich: A0EQ0T - news) 's patented, nano-structured, tungsten carbide component coatings to new and existing oil and gas customers worldwide.

Wainwright is experienced in the highly-technical process of selling of industrial surface coatings for use in extremely challenging environments. Most recently Martin was with CTW (Hardfacing) / Celcoat, where he built a successful track record in identifying and selling into new markets worldwide. Previously, he held sales and technical positions with Mayflower Engineering, Star Precision and Devol Engineering.

The company also said that it has recently added one of the largest global providers of oilfield services and products to its customer list and is developing several new applications for five blue chip oilfield services companies. New orders have been secured from two downhole drilling tool manufacturers and an oil and gas valve manufacturer. In addition, tests are underway with several smaller drilling-related companies.

Philip Kirkham, Chief Executive Officer of Hardide Coatings said: "Hardide has enjoyed success with a mix of the leading international oilfield service companies and smaller, innovative downhole tool developers but the recruitment of Martin will take us to the next level in an industry where Hardide can offer operators and service companies significant cost savings through reduced downtime and extended tool and valve life."

The share price rose 3.64% to 0.85p by 13:11.

NR

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Hardide appoints a Business Development Manager

NANO Connect Offers International Perspective With South Korean Nanotechnology Education Leader

SKOKIE, IL--(Marketwire - Oct 3, 2012) - Wheeling High School, a recognized Blue Ribbon School by the U.S. Department of Education, announced today that Dr. WeonBae Ko, a Professor in the Department of Chemistry at Sahmyook University in Seoul, South Korea, and the leader of the Korean Nanotechnology Researchers Society's Nanotechnology Education Committee, will give a presentation on the state of nanotechnology education in South Korea at its upcoming NANO Connect forum.

NANO Connect is a forum aimed at demystifying the rapidly emerging field of nanotechnology and demonstrating how nanotechnology education can be integrated into traditional high school science curriculums.It is sponsored by NanoProfessor, the global leader in hands-on undergraduate nanotechnology education, which has been chosen to serve as the foundation for undergraduate hands-on nanotechnology education by over twenty institutions in five countries.

"We are honored to have Dr. Ko speak at our inaugural NANO Connect forum and enlighten us on the state of nanotechnology education in South Korea," said Dr. Lazaro Lopez, Principal of Wheeling High School."Dr. Ko's presence at NANO Connect speaks to the growing importance of nanotechnology education both locally and internationally."

"I want to thank Dr. Lopez for inviting me to speak at NANO Connect, which will be a great opportunity to exchange ideas about nanoscience education," said Dr. Ko."South Korea is aiming to become one of the world's top three nations in global nanotechnology competitiveness by 2015.To do this, we are focusing on research and development, research infrastructure, and manpower cultivation, all of which start with education."

The NANO Connect forum will be held at Wheeling High School on Tuesday, October 9 from 8 a.m. to noon and will also feature keynote addresses from Illinois Congressman Bob Dold; Gayle E. Woloschak, Ph.D., Professor at Northwestern University; and Ted Fetters, Director of Program Management for the Illinois Science and Technology Coalition.The NANO Connect forum is open to students, educators, and those working in the nanotechnology field.In addition to the keynote addresses, graduate students from Northwestern University's International Institute for Nanotechnology will give hands-on demonstrations to Wheeling High School students, showcasing nanotechnology and its applications.

The event will also feature a display of the state-of-the-art, nano-focused instrumentation contained within the NanoProfessor Nanoscience Education Program, including NanoInk's NLP 2000 Desktop Nanofabrication System, the first desktop nanofabrication system allowing students to quickly and easily build custom-engineered nanoscale structures with a wide variety of materials from metal nanoparticles to biomolecules using NanoInk's proprietary Dip Pen Nanolithography (DPN).Local companies working in the nanotechnology industry will be in attendance, as well.More information about NANO Connect, including registration, is available at: http://whs.d214.org/academics/nano_conference.aspx

Nanotechnology is the understanding and control of matter at dimensions between approximately one and 100 nanometers (nm), where unique phenomena enable novel applications which are not feasible when working with bulk materials.A nanometer is one-billionth of a meter.Encompassing nanoscale science, engineering, and technology, nanotechnology involves imaging, measuring, modeling, and manipulating matter at the nanoscale.A study funded by the National Science Foundation projects that six million nanotechnology workers will be needed worldwide by 2020, with two million of those jobs in the United States.However, as of 2008, there were only 400,000 estimated workers worldwide in the field of nanotechnology, with an estimated 150,000 of those in the United States.

Wheeling High School is a public, four-year comprehensive high school with a STEM focus that opened in 1964 and graduated its first class in 1966.It serves Wheeling and sections of Arlington Heights, Buffalo Grove, Mount Prospect, Northbrook, and Prospect Heights and is one of the six schools in Township High School District 214.In the fall of 2010, Wheeling High School was officially rededicated as a STEM school and admitted as an institutional member of the National Consortium for Specialized Secondary Schools of Mathematics, Science, and Technology -- one of only three in Illinois.More information is available at: http://whs.d214.org.

About the NanoProfessor Nanoscience Education Program The NanoProfessor Nanoscience Education Program aims to advance undergraduate nanotechnology education and address the growing need for a skilled, nano-savvy workforce.The NanoProfessor Program, including instruments, an expert-driven curriculum, and student/teacher support materials, is available for high schools, community colleges, technical institutes, and universities worldwide.More information is available at: http://www.NanoProfessor.net or (847)679-NANO (6266).You can also like NanoProfessor on Facebook at http://www.facebook.com/NanoProfessor1 and follow on Twitter at http://www.twitter.com/nanoprofessor1.

NanoInk, NanoProfessor, Dip Pen Nanolithography, DPN, and the NanoProfessor logo are trademarks or registered trademarks of NanoInk, Inc.

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NANO Connect Offers International Perspective With South Korean Nanotechnology Education Leader

CollabRx Partners with Life Technologies in Molecular Diagnostics

SAN FRANCISCO--(BUSINESS WIRE)--

CollabRx, Inc. (CLRX) today announced a multi-year partnership agreement with Life Technologies Corporation for development and commercialization of CollabRx technology and content resources to be used in conjunction with Life Technologiesglobal cancer diagnostics development and its laboratory developed test services business. The agreement represents a major step forward by CollabRx in providing laboratories and next-generation sequencing (NGS) companies with meaningful insights into cancer.

Molecular analysis, including genetic sequencing, is increasingly becoming an important part of the clinical management of cancer patients, said James Karis, Co-CEO of CollabRx. However, the sheer volume and complexity of genetic data that is being produced, particularly in the course of therapy development, is outpacing the ability of practicing physicians to stay current, and more importantly understand how to apply this genetic data in treating their patients.

CollabRx, Inc., a data analytics company focused on genomics, bridges this knowledge gap using cloud-based expert systems to inform healthcare decision-making by aggregating and contextualizing the worlds knowledge on molecular medicine with specific insights from the nations top clinical experts.

Life Technologies will use CollabRx proprietary content and technology to pair the results of broad molecular profiling panels developed by Life Technologies with associated clinically relevant and dynamically updated knowledge on clinical trials, drugs, biologics and other information relevant for cancer treatment planning. This knowledge is supported by CollabRxs large and growing network of over 50 leading clinical practitioners in the United States. While CollabRx and its advisors do not provide specific treatment recommendations, this clinically relevant knowledge is a key part of the context engine for informing healthcare decision-making.

Its critical to contextualize the results of complex cancer panels to make them useful for interpreting and treating physicians, saidRonnie Andrews, president of Medical Sciences atLife Technologies. CollabRx has pioneered the development of a scalable platform and process to provide actionable, accessible, and credible knowledge at the point of care to aid physicians in developing a cancer treatment plan based on tumor molecular profiles. We are excited to include this key capability with our molecular diagnostic tests.

As the genomics revolution continues to unfold, successful cancer diagnostic companies will need cutting-edge technologies as well as deep, personalized analytics, said Thomas Mika, Co-CEO of CollabRx. We are thrilled to be a part of Life Technologies strategy to establish a leadership position in the clinical diagnostics market by providing ordering physicians with clinically relevant interpretation of test results, personalized for each patient, as a seamless part of the reporting process via Web-based and mobile technologies.

About CollabRx

CollabRx, Inc. (CLRX) is a recognized leader in cloud-based expert systems to inform health care decision-making. CollabRx uses information technology to aggregate and contextualize the worlds knowledge on genomics-based medicine with specific insights from the nations top cancer experts starting with the area of greatest need: advanced cancers in patients who have effectively exhausted the standard of care. More information may be obtained at http://www.collabrx.com.

CollabRx Safe Harbor Statement

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CollabRx Partners with Life Technologies in Molecular Diagnostics