Libertarian candidates plead not guilty to marijuana charges

Two Libertarian candidates for the Montana Legislature pleaded not guilty on Wednesday to charges stemming from an incident in which marijuana-infused candy was distributed on a Hamilton school bus.

Karen Renae Fisher, 27, pleaded not guilty to criminal possession of dangerous drugs and criminal production of dangerous drugs, both felonies.

Fisher is a Libertarian candidate running for House District 87. Ravalli County District Court Judge Jeffrey Langton lifted the no contact order for Fisher and her alleged co-conspirators, but they were told not to discuss the case. Fishers omnibus hearing is set for Oct. 24 at 9 a.m.

Robert Wayne McCoy, 38, also pleaded not guilty to operation of an unlawful clandestine laboratory, criminal possession of dangerous drugs with intent to distribute, criminal distribution of dangerous drugs, each felonies, and endangering the welfare of children, criminal possession of drug paraphernalia, unlawful conduct by a cardholder, all misdemeanors.

McCoy is a Libertarian candidate running for Senate District 45. Conditions set in Ravalli County Justice Court stated that McCoy was to not possess marijuana or his medical marijuana card.

McCoy told Langton that he was innocent and Langton told McCoy that he must enter guilty, not guilty or no contest. McCoy said, Your honor, I am innocent. Langton then entered a not guilty plea on McCoys behalf.

Langton looked at McCoys medical marijuana card that expires soon. McCoy said that he has not renewed the card due to the conditions set in justice court.

Langton did place an order that McCoys residence can have an unannounced inspection by sheriffs deputies without a warrant at anytime.

Finally, Fishers husband, Jeffery Allen Fisher, 30, pleaded not guilty to criminal possession of dangerous drugs and criminal production or manufacture of dangerous drugs, both felonies. His omnibus hearing is set for Oct. 24 at 9 a.m.

McCoys wife, Andrea Michelle McCoy, 35, is charged with operation of unlawful clandestine laboratory, criminal possession of dangerous drugs, both felonies and endangering the welfare of children, a misdemeanor. Her initial appearance was postponed to Oct. 17 at 9 a.m.

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Libertarian candidates plead not guilty to marijuana charges

Libertarian Gary Johnson pans debate

Republican Presidential nominee Mitt Romney speaks while President Barack Obama makes notes at the first Presidential debate at the University of Denver's Ritchie Center on October 3, 2012 in Denver. UPI/Gary C. Caskey

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Published: Oct. 4, 2012 at 12:28 AM

DENVER, Oct. 4 (UPI) -- Libertarian presidential nominee Gary Johnson said Wednesday's debate between U.S. President Obama and Republican rival Mitt Romney wasn't really a debate.

The former New Mexico governor said in a statement Romney and Obama's debate in Denver provided "two slightly differing versions of defending the Republican and Democrat status quo that has given us war after war after war, a $16 trillion debt, and a government that is the answer to everything."

"Nowhere was there a real plan for reducing government, balancing the budget any time in the foreseeable future, or a path that will actually put Americans back to work," Johnson said. "We heard two politicians arguing over which of their plans for government-run health care is less bad. We heard fantasies about balancing the budget while not reducing Medicare costs."

Johnson said the two candidates were merely "nibbling around the edges of the nation's problems."

"We don't have time to nibble -- we need to devour them," he said. "Americans deserve real debates and a voice who will actually tell the truth about what it will take to put this great nation back on track."

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Libertarian Gary Johnson pans debate

South Korea makes a point about its claim on islands disputed with Japan

DOKDO/TAKESHIMA ISLANDS These two tiny volcanic islands, poking up from the sea like rabbit ears, can be scaled only by wooden steps that ascend almost vertically. A pulley system hauls food to a cafeteria built 300 feet above the waves. The only mailbox on the islands has a notice stenciled on the front, reminding that service will be slow because mail is picked up every two months.

The postal box is a symbolic object, the sign reads, implying South Koreas control.

These islands, administered by South Korea but claimed by Japan, provide a window into Asias fastest-growing problem, the fight over small bits of land that have oversize and symbolic importance.

In the case of these islands, known as Dokdo in Korea and Takeshima in Japan, the show of Korean control is pushed to extremes: Only two civilians live here, a fisherman and his wife, but three South Korean telecommunications companies provide the islands with 3G cellphone service.

The notion of symbolic control has grown increasingly important in recent months amid a region-wide surge of nationalism and upcoming political leadership changes in South Korea, Japan and China. As a result, countries that once downplayed territorial disputes now use them to foment national pride. These small islands have become dangerous friction points between Asias most economically linked countries, with all sides calling their claims irrefutable and just, and brushing aside the idea of compromise.

The fierce dispute between Japan and China over islands in the East China Sea has sparked greater fears about potential armed conflict, but the dispute over Dokdo has already levied a toll of its own. It has stalled military cooperation between Washingtons two closest Asian allies and reignited historical animosities that date back to Japans brutal, region-wide land-grab before World War II.

The South Korean central government took a dozen foreign journalists to the island Thursday to underscore its claims. The journalists started their day in Seoul at a just-opened downtown Dokdo museum and later took the three-hour flight to the islands, in time for lunch at the cafeteria, which normally serves the national police who live here on two-month rotations.

Dokdo consists of two main islands and a handful of rocky droplets, which do little more than break waves. The taller of the two, with a razor-sharp backbone, has two residents, the fisherman and his wife, who catch octopus and live in a three-story home paid for by the provincial government along the shore.

Its not as big as it looks, the fisherman, Kim Sung-do, said. The top floor is all water tanks for storing drinkable water.

The stouter of the main islands has a helicopter pad, a lighthouse, a weight room, a small branch of the South Korean national library and a dormitory. Forty-five police live here, as do two civil servants and three lighthouse attendants. There are no women. There is one dog, named Seodo.

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South Korea makes a point about its claim on islands disputed with Japan

ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research

REYKJAVIK, Iceland, October 4, 2012 /PRNewswire/ --

ORF Genetics announced today that the company has added endotoxin- and animal-free human Fibroblast Growth Factor Basic (FGF basic) and mouse Leukemia Inhibitory Factor (mouse LIF) to its portfolio of growth factors for stem cell research.

Most growth factors applied in stem cell research today are made in E. coli bacteria, which produce endotoxins that can have adverse effect on stem cell cultures. Other manufacturers of growth factors have various methods to remove these endotoxins, but traces inevitably remain, which can lead to increased death rate of cells and other suboptimal effects in cell cultures. Other growth factors on the market today are made by animal cells. However, most stem cell researchers prefer to use growth factors of non-animal origin to exclude risks of viral contamination and the inclusion of growth factor homologs.

This has led to a market demand for alternative sources of animal-free growth factors, void of endotoxins. ORF Genetics' unique growth factors are produced in the seeds of the barley plant, which does not produce any endotoxins or other substances toxic to mammalian cells.

FGF basic and mouse LIF are key growth factors for the cultivation of their respective stem cells, i.e. FGF basic for human stem cells and mouse LIF for mouse stem cells. Each protein is used to expand the stem cells' populations before researchers make them differentiate into various cell types, such as heart, liver or neural cells.

"ORF Genetics has built a reputation for offering the first plant-made, endotoxin-free and animal-free growth factor portfolio for stem cell researchers. As we are producing these growth factors in our novel plant expression system ORFEUS, we are very happy to be able to offer these high quality growth factors at more efficient prices than market leaders," said Bjrn rvar, CEO of ORF Genetics.

ORF Genetics is a world leader of plant made growth factors and offers a portfolio of endotoxin- and animal-free growth factors for human stem cell research. The company's production takes place in a biorisk-free production system in barley, bypassing conventional bacteria and animal cell production systems. The cultivation of barley takes place in greenhouses in inert volcanic pumice, using renewable geothermal energy.

For more information please contact:

Dr. Hakon Birgisson, Director of Global Market Development Tel: +354-821-1585 email:hakon.birgisson@orfgenetics.com

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ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research

Why US Health Care Costs More Than Canada’s: "A Mercedes Costs More than a Corolla" – Video

04-10-2012 10:14 "The American [health care] system is more expensive than the Canadian system," says Michel Kelly-Gagnon, president of the Montreal Economic Institute. "To that, I answer that a Mercedes is indeed more expensive than a Toyota Corolla." "Thank god for that," he says, explaining that innovation depends on early adopters who are far more likely to be well-off and pay high rates for new and better options. That doesn't mean only the rich benefit, though. "Certain treatments that are only available to the richest people," he says, "will eventually become more economical and the whole world will benefit." Kelly-Gagnon says that some variation on universal coverage is already a "political reality" in most developed countries, where citizens don't let large numbers of people die from curable diseases. But the focus on coverage rates obscures the problems created by single-payer systems such as Canada's, where costs are kept down via rationing and long wait times for services taken for granted in the United States. "Once you've established that [universal coverage] is how it's going to be," says Kelly-Gagnon, the real question is "how do you find more private solutions" that will serve more people at better rates. About 3.20 minutes. Produced by Anthony L. Fisher. Camera by Josh Swain. Visit for downloadable versions and visit to subscribe to our videos.

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Why US Health Care Costs More Than Canada's: "A Mercedes Costs More than a Corolla" - Video

Philippine Business News | Online News Philippines

Details Published on Thursday, 04 October 2012 00:00 Written by AMADO P. MACASAET

It is becoming clear that health care is being used by the supporters of heavy taxes on smoke as a ploy or cover to collect more money from the tobacco industry.

The authors and supporters of HB 5727, the new excise tax proposal, are making us look like fools by making us believe the rates in the bill must be applied for the sake of the health of smokers.

The truth is there is money P50 billion of it, according to Senator Ralph Recto which should be remitted to PhilHealth and to the Department of Health for one single purpose health care.

Recto, chairman of the Senate ways and means committee yesterday repeated his charge that there is at least P12.5 billion from cigarette excise tax that should have been remitted to the Department of Health to fight smoking-related diseases notably lung cancer.

Obviously, the Department of Budget and Management which unconditionally support heavier taxes on cigarettes, never remitted the tax money to the Department of Health. But some lawmakers ably aided by the Department of Finance want more money from the cigarette makers.

It is becoming clear that health care is being used by the supporters of heavy taxes on smoke as a ploy or cover to collect more money from the tobacco industry. They have raised enough but the money is not used for the purpose they say it will be used for, that is to fight smoking-related diseases.

The refusal of the DBM to release the money to the Department of Health is a clear violation of RA 9334 which states that two and a half percent of the incremental revenue from excise on alcohol and tobacco products starting January 2005 shall be credited to the account of the Department of Health and constituted as a trust fund for its disease prevention program.

Another 2.5 percent from the same sources shall be remitted directly to the Philippine Health Insurance Corp. for the purpose of meeting and sustaining the goal of universal coverage of the National Health Insurance Program.

In other words, 5 percent of excise tax collected from sin products is clearly intended for health care.

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Philippine Business News | Online News Philippines

Independence Blue Cross Executive to Speak on the Changing Health Care Market

PHILADELPHIA, Oct. 4, 2012 (GLOBE NEWSWIRE) -- Independence Blue Cross (IBC) is proud to announce that Christopher Cashman, executive vice president and president of commercial markets, will join other health care leaders at an annual industry conference this afternoon hosted by the Greater Philadelphia Association of Health Underwriters (GPAHU). Cashman will speak at the conference on how IBC is embracing change and investing in new ways to enhance its customers' health and wellness, lower costs, and improve the quality of care.

"This is a time of remarkable transformation in health care. We are committed to exceeding our customers' expectations through innovative health and wellness solutions, and that means embracing change," said Cashman. "It's a privilege to have the opportunity to speak today at the annual GPAHU conference. At Independence Blue Cross, we value our strong relationship with brokers, agents, and consultants and the guidance they provide our customers."

The conference began at 9 a.m. today in Drexel Hill, Pennsylvania, with keynote speaker Pennsylvania State Insurance Commissioner Michael F. Consedine. Cashman is co-presenting with regional leaders from the health insurance industry on embracing change now that the health care reform law has been upheld by the U.S. Supreme Court.

During the conference, Cashman will discuss how IBC is boldly leading the transformation of health care in the region. IBC is pioneering innovative ways to partner with hospitals and physicians to reward them for higher--quality, more coordinated care. IBC also offers innovative programs to help its members take an active role in making healthier choices

About Independence Blue Cross

Independence Blue Cross is a leading health insurer in southeastern Pennsylvania. With our affiliates, we have 3.1 million members nationwide. For nearly 75 years, we have been enhancing the health and wellness of the people and communities we serve by delivering innovative and competitively priced health care products and services; pioneering new ways to reward doctors, hospitals, and other health care providers for coordinated, quality care; and supporting programs and events that promote wellness. To learn more about how we're changing the game, visit http://www.ibx.com. Connect with us on Facebook at ibx.com/facebook and on Twitter at @ibx. Independence Blue Cross is an independent licensee of the Blue Cross and Blue Shield Association.

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Independence Blue Cross Executive to Speak on the Changing Health Care Market

OPINION: Flaws that will unravel Obama’s health plan

The debate over President Barack Obamas health-care law has taken another twist. Now conservatives and libertarians are defending it, while the administration tries to toss part of the legislation out.

The reason for this role reversal is that the drafters of the law outsmarted themselves and handed their opponents a weapon. Now they would like to pretend the law doesnt say what it does.

Obamas plan makes tax credits available to people who get health insurance from exchanges set up by state governments. If states dont establish those exchanges, the federal government will do so for them. The federal exchanges, however, dont come with tax credits: The law authorizes credits only for people who get insurance from state-established exchanges. And that creates some problems the administration didnt foresee, and now hopes to wish away.

Legislative debate over the law didnt go into great detail about these provisions. We can surmise what happened, though. Supporters of the legislation wanted to encourage states to set up the exchanges. So they offered the states a deal: If they did so, they would get to write their own rules, and their citizens would be able to get the tax credit. The states would also gain extra flexibility on Medicaid spending. The laws supporters also expected the health-care law to become more popular over time.

That hasnt happened. Many states are determined in their opposition, and few of them have set up exchanges. If they dont do so, the tax credits dont go into effect and the federally established exchanges wont work: People wont be able to afford the insurance available on them without the subsidy.

States have another incentive to refrain from setting up exchanges under the health-care law: It protects companies and individuals in the state from tax increases. The law introduces penalties of as much as $3,000 per employee for firms that dont provide insurance but only if an employee is getting coverage with the help of a tax credit. No state exchanges means no tax credits and thus no employer penalties. The law also notoriously penalizes many people for not buying insurance. In some cases, being eligible for a tax credit and still not buying insurance subjects you to the penalty. So, again, no state exchange means no tax credit and thus fewer people hit by the penalty.

The administrations response to the impending failure of its signature legislation a failure resulting entirely from its flawed design has been to ignore the inconvenient portion of the law. In May, the Internal Revenue Service decided it would issue tax credits to people who get insurance from exchanges established by the federal government. It has thus exposed firms and individuals to taxes and penalties without any legal authorization. Obviously, that situation sets the stage for lawsuits.

The plaintiffs will have a strong case. Jonathan Adler and Michael Cannon two libertarians, the first a law professor at Case Western Reserve University and the second a health-care analyst at the Cato Institute have done more than anyone to bring attention to this issue. They point out that every health bill advanced by Senate Democrats clearly made tax credits conditional on states establishment of exchanges. They have also uncovered that during the debate over the bill, Sen. Max Baucus, a Democrat from Montana, explicitly said the same thing.

Supporters of the health-care law may be tempted to dismiss the challenge to the IRS. That would be to repeat a mistake. They were contemptuous of the constitutional case against the law, too. Timothy Jost, a Washington and Lee University law professor, even wrote that the attorneys who brought the suits should face professional sanctions for filing frivolous cases. In the end, the Supreme Court sided with the plaintiffs on their constitutional claims, in one case by a 7-2 margin, upholding the law only by removing parts of it.

There will be many more court battles over the health-care law, because it involves so many legally dubious expansions of bureaucratic power. In addition to the IRS move, there are lawsuits against the administrations ruling that almost all employers must provide coverage for contraception and sterilization, a decision that conflicts with the Religious Freedom Restoration Act. The law also creates a board of experts to control health-care costs, a move that is sure to bring legal action on separation-of- powers grounds.

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OPINION: Flaws that will unravel Obama’s health plan

Henry Schein and Henry Schein Cares Foundation Partner with National Association of Community Health Centers to …

MELVILLE, N.Y., Oct. 4, 2012 /PRNewswire/ --Henry Schein, Inc. (HSIC), the world's largest provider of health care products and services to office-based dental, medical and animal health practitioners, today announced a new five-year agreement with the Henry Schein Cares Foundation, Inc. and the National Association of Community Health Centers (NACHC) to increase access to care for underserved communities. Under the new agreement, NACHC will participate in two Henry Schein Cares flagship initiatives: Henry Schein's Global Product Donation Program and the Healthy Lifestyles, Healthy Communities initiative.

(Photo: http://photos.prnewswire.com/prnh/20121004/NY86519 )

Under the agreement, every two years 10 new NACHC member health centers will participate in Henry Schein's Global Product Donation Program and each receive donated dental and medical products for a term of two years, valued at between $5,000 and $25,000. To learn more about the Global Product Donation Program, please visit: http://www.hscaresfoundation.org/globalproductDonation.asp.

In addition, approximately 10 NACHC member health centers will each annually receive Healthy Lifestyles, Healthy Communities grants. The Henry Schein Healthy Lifestyles, Healthy Communities initiative promotes access to health care, prevention, and wellness for at-risk and underserved communities by providing free medical and oral health screenings for thousands of children and their caregivers at events around the country.To learn more about the Healthy Lifestyles, Healthy Communities Program, please visit: http://www.hscaresfoundation.org/healthylifestyles.asp.

"The new partnership between Henry Schein and NACHC underscores our shared strong commitment to helping America's community health centers deliver excellent quality care to all," said Stanley M. Bergman, Chairman and Chief Executive Officer of Henry Schein, Inc. "Through Henry Schein's expertise and our comprehensive range of offerings covering the full spectrum of medical, oral health, and technology solutions, we are proud to support the role of community health centers as health homes to tens of millions of patients around the country. And through this new partnership, we are gratified to further enhance the ability of community health centers to 'help health happen' for those in need through their participation in our Global Product Donation and Healthy Lifestyles, Healthy Communities programs."

Henry Schein's program, "HealthHome: Solutions for Coordinating Prevention and Wellness" provides full spectrum medical and oral health support to the nation's community health care centers, including supplies and equipment; electronic health care records software; health center design and planning; and 340B, diagnostic, and influenza vaccine programs. As part of Henry Schein's strong support of community health centers across the country, the Company also recently provided financial sponsorship, on-site volunteers, executive speakers, and other support for National Health Center Week 2012 events in California, North Carolina, Colorado and Missouri.

"We are pleased to enter into this partnership with Henry Schein and Henry Schein Cares Foundation," said Tom Van Coverden, President and CEO of the National Association of Community Health Centers. "The partnership represents the commitment of the parties to improve health care for the most vulnerable people in America. The two signature programs that will be made available to a number of community health centers over the period of the partnership will result in increased resources for health centers as well as improved access to care for patients in underserved communities."

About the National Association of Health CentersThe National Association of Community Health Centers was founded in 1971. Its mission is to promote the provision of high quality, comprehensive and affordable health care that is coordinated, culturally and linguistically competent, and community directed for all medically underserved populations. NACHC represents over 1,200 health centers that serve more than 20 million patients at over 8,000 sites in the United States and its territories.

About Henry Schein Cares and the Henry Schein Cares Foundation, Inc.Henry Schein Cares, Henry Schein's global corporate social responsibility program, stands on four pillars: engaging Team Schein Members to reach their potential, ensuring accountability by extending ethical business practices to all levels within Henry Schein, promoting environmental sustainability, and expanding access to health care for underserved and at-risk communities around the world. Health care activities supported by Henry Schein Cares focus on three main areas: advancing wellness, building capacity in the delivery of health care services, and assisting in emergency preparedness and relief. Firmly rooted in a deep commitment to social responsibility and the concept of enlightened self-interest championed by Benjamin Franklin, the philosophy behind Henry Schein Cares is a vision of "doing well by doing good." Through the work of Henry Schein Cares to enhance access to care for those in need, the Company believes that it is furthering its long-term success.

Established in 2008, Henry Schein Cares Foundation, Inc., a 501(c)(3) organization, works to foster, support, and promote dental, medical, and animal health by helping to increase access to care for communities around the world.

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Henry Schein and Henry Schein Cares Foundation Partner with National Association of Community Health Centers to ...

Analyzing health-care statements

President Barack Obama and Mitt Romney had at it out over health care Wednesday night providing some of the toughest, and wonkiest, moments of the night.

Both candidates also showed they had done their research, citing studies to back their claims about Obama's health care law and how the other would cut Medicare spending but they both managed to stretch the truth.

Here are the highlights of their claims in Wednesday nights debate:

Romney claim: On Medicare, for current retirees, hes cutting $716 billion from the program.

Misleading. If Romney had worded his statement more narrowly for example, by saying only that Obama is cutting Medicare spending by $716 billion it would have been true. That is the amount of spending the health reform law will save by reducing payments to Medicare providers and private Medicare Advantage plans. But Romney said it in a way that suggests that the cuts will come out of current retirees pockets, by slicing their benefits, and that framing stretches the truth.

Obama claim: The Republican Medicare plan would cost the average senior about $6,000 a year.

Questionable. Obama covered himself by pointing out that this estimate applied to Paul Ryans original Medicare plan. At the time, the Center on Budget and Policy Priorities, a liberal think tank, estimated that the plan would shift nearly $6,400 in costs to seniors. But that plan had a hard limit on how much could be spent on Medicare each year and Romneys campaign insists that his plan has no such limit.

Obama doesnt buy Romneys argument that competition among private plans alone will bring down costs. He argued that Medicare has lower administrative costs than private insurance does, and that if you are going to save any money through what Gov. Romney's proposing is that the money has to come from somewhere. But he did acknowledge that Romneys plan is different from the Ryan plan and that in fairness, what Gov. Romney has now said is he'll maintain traditional Medicare alongside it.

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Analyzing health-care statements

Toward Health for All

How can a compassionate humanity meet the health care needs of the more than 2 billion people who live on less than $2 per day? As chairman of the Novartis Foundation for Sustainable Development, Klaus M. Leisinger works to alleviate poverty-related health problems in the developing world at three levels: on-the-ground assistance with health care services and medicine; connecting global health ...

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Toward Health for All

Health-care Stocks: After debate, hospital investors head for exits

By Russ Britt, MarketWatch

LOS ANGELES (MarketWatch) Investors in hospitals started heading for the exits in the wake of President Barack Obamas lackluster debate performance by selling off shares in virtually all companies in the sector early Thursday.

With the prospect that Obama who spearheaded the health-care overhaul bill that gives aid to hospital balance sheets could be vulnerable in his re-election bid against Republican Mitt Romney, shares plunged even though the broader market enjoyed substantial gains.

The Dow Jones Industrial Average /quotes/zigman/627449 DJIA +0.68% was up more than half a percent, as was the S&P 500. /quotes/zigman/3870025 SPX +0.67%

A review of Wednesday night's debate between Mitt Romney and President Barack Obama, and a look at how to get a handle on health-care spending.

Most analysts agreed that Romneys aggressive tack in Wednesdays debate gave him the edge over the incumbent Democrat. Romney has vowed to repeal the health-care bill, which would force hospitals to return to the practice of writing down large chunks of revenue due to those unable to pay for medical care.

Thats making investors nervous, since the debate raised the prospect that Romney could unseat Obama.

By requiring more people to get coverage, the health-care overhaul bill is expected to cut back on the bad debt that virtually all hospitals record on their balance sheets, since they cant turn away patients in emergencies.

In a morning note to clients, CRT Capital Group analyst Sheryl Skolnick said: After an at-best lackluster and at-worst pitiful performance by President Obama in last nights debate, health care investors have to be wondering this morning whether the reform-on play of the last several weeks is the right one going into the Nov. 6 election.

She added: Investors who are long hospital stocks this morning should be thinking, Thanks a lot, Mr. President, at least in our view.

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Health-care Stocks: After debate, hospital investors head for exits

New Screening System Diagnoses Genetic Diseases In Two Days

Connie K. Ho for redOrbit.com – Your Universe Online Technology is changing faster than ever. With the click of a button you can send messages to friends, share photos and watch videos. This rapid speed is also being seen in medical technology. A new study found that doctors can quickly diagnose genetic diseases in babies with a simple blood test, allowing doctors to decode the baby’s complete ...

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New Screening System Diagnoses Genetic Diseases In Two Days

Rapid gene-mapping test may diagnose disease in newborns

WASHINGTONToo often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit -- and may offer testing for babies elsewhere, too -- while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

"For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," he added.

More than 20 percent of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases -- from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes - all of a person's DNA - can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours -- half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

That's an estimate: The study counted only the time the blood was being decoded or analyzed, not the days needed to ship the blood to Essex, England, home of a speedy new DNA decoding machine made by Illumina, Inc. -- or to ship back the results for Children's Mercy's computer program to analyze. Kingsmore said the hospital is awaiting arrival of its own decoder, when 50 hours should become the true start-to-finish time.

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Rapid gene-mapping test may diagnose disease in newborns

BWH researchers discover genetic risk for uterine fibroids

Public release date: 4-Oct-2012 [ | E-mail | Share ]

Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-2208 Brigham and Women's Hospital

BOSTON, MAUterine fibroids are the most common type of pelvic tumors in women and are the leading cause of hysterectomy in the United States. Researchers from Brigham and Women's Hospital (BWH) are the first to discover a genetic risk allele (an alternative form of a gene) for uterine fibroids in white women using an unbiased, genome-wide approach. This discovery will pave the way for new screening strategies and treatments for uterine fibroids.

The study will be published online on October 4, 2012 in The American Journal of Human Genetics.

The research team, led by Cynthia Morton, PhD, BWH director of the Center for Uterine Fibroids and senior study author, analyzed genetic data from over 7,000 white women. The researchers detected genetic variants that are significantly associated with uterine fibroid status in a span of three genes including FASN which encodes a protein called FAS (fatty acid synthase).

Moreover, additional studies revealed that FAS protein expression was three times higher in uterine fibroid samples compared to normal myometrial tissue (muscle tissue that forms the uterine wall). Over-expression of FAS protein is found in various types of tumors and is thought to be important for tumor cell survival.

"Our discovery foretells a path to personalized medicine for women who have a genetic basis for development of uterine fibroids," said Morton. "Identification of genetic risk factors may provide valuable insight into medical management."

Study samples used were from various cohort studies, such as the Finding Genes for Fibroids study and the Women's Genome Health Study at BWH.

Uterine fibroids may lead to abnormal vaginal bleeding, infertility, pelvic pain and pregnancy complications. Uterine fibroids are found in more than 75 percent of women of reproductive age.

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BWH researchers discover genetic risk for uterine fibroids

No on Proposition 37

There's a growing gap between what grocery shoppers think they know about their food and the reality. Those tomatoes with the evenly rich red color that look ripened to perfection? They were bred to avoid showing streaks of green, a result of genetic prodding that also stole away most of their flavor. Unless the carton says otherwise, the eggs didn't come from chickens that scratched around in barnyards but rather spent their lives in cramped battery cages that offered no room to move around. There's a good chance the meat came from animals that were given antibiotics from their youngest days, both to promote growth and to prevent disease from sweeping through their crowded pens. Pesticides were almost certainly used on the fruits and vegetables. And the sweetener in the soda, or the golden corn on the cob, probably was a product of genetic engineering.

In most cases, there is no requirement to inform consumers, via labels, about the use of pesticides, hormones or antibiotics, or about the inhumane conditions in which animals are often kept. But Proposition 37 would make an exception for genetically engineered food, requiring that it be labeled before being sold in California. Although we generally endorse people's right to know what goes into their food, this initiative is problematic on a number of levels and should be rejected.

Genetic engineering tinkering with genes in a laboratory to produce desirable qualities has dominated the production of certain crops for years. Today, somewhere between 85% and 95% of the corn and soybeans grown in this country, for example, have altered genes. Often, the alteration renders the crops "Roundup ready," which means they're able to withstand the herbicide glyphosate, marketed by Monsanto under the trade name Roundup. That allows farms to spray against weeds without killing the food plants. And because corn and soy appear in so many products in the form of high-fructose corn syrup, as just one example genetically engineered ingredients are common in processed foods.

ENDORSEMENTS: The Times' recommendations for Nov. 6

Unfortunately, the initiative to require labeling of those ingredients is sloppily written. It contains language that, according to the nonpartisan Legislative Analyst's Office, could be construed by the courts to imply that processed foods could not be labeled as "natural" even if they weren't genetically engineered. Most of the burden for ensuring that foods are properly labeled would fall not on producers but on retailers, which would have to get written statements from their suppliers verifying that there were no bioengineered ingredients a paperwork mandate that could make it hard for mom-and-pop groceries to stay in business. Enforcement would largely occur through lawsuits brought by members of the public who suspect grocers of selling unlabeled food, a messy and potentially expensive way to bring about compliance.

These are all valid arguments for rejecting Proposition 37, but a more important reason is that there is no rationale for singling out genetic engineering, of all the agricultural practices listed above, as the only one for which labeling should be required. So far, there is little if any evidence that changing a plant's or animal's genes through bioengineering, rather than through selective breeding, is dangerous to the people who consume it. In fact, some foods have been engineered specifically to remove allergens from the original version. By contrast, there is obvious reason to be worried about the fact that three-fourths of the antibiotics in this country are used to fatten and prevent disease in livestock, not to treat disease in people. The rise of antibiotic-resistant bacteria from overuse of pharmaceuticals poses a real threat to public health. So why label only the bioengineered foods? Because the group that wrote Proposition 37 happened to target them. What's needed is a consistent, rational food policy, not a piecemeal approach based on individual groups' pet concerns.

That's not to belittle consumer doubts about genetically engineered foods. The nation rushed headlong into producing them with lax federal oversight, and although many studies have been conducted over the last couple of decades, a 2009 editorial in Scientific American complained that too much of the research has been controlled by the companies that create the engineered products. The solution, though, is more independent study and, if necessary, stronger federal oversight and legislation, not a label that would almost certainly raise alarm about products that haven't been shown to cause harm.

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The more substantiated issue with genetically engineered foods is their effect on the environment and possibly on other crops. The over-reliance they've encouraged on a single herbicide has contributed to the emergence of Roundup-resistant weeds. The industry is now seeking federal permission to grow corn that can withstand a different, more problematic herbicide. The Obama administration should withhold permission until agribusiness comes up with a better long-term solution than creating ever-tougher weeds.

Meanwhile, the marketplace already provides ways to inform consumers about their food. Just as some meats are labeled antibiotic-free or hormone-free, and some eggs are labeled cage-free, food producers are welcome to label their foods as GE-free. The Trader Joe's grocery chain has helped market itself to concerned consumers by announcing that its private-label foods do not contain genetically engineered ingredients. Organic foods are never genetically engineered. There are no genetically engineered versions of most fruits sold in markets.

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No on Proposition 37