Dr. Arnold Levine Joins GeneCentric Board of Directors

DURHAM, N.C., Sept. 26, 2012 /PRNewswire/ -- GeneCentric, a molecular diagnostics company focused on personalized oncology today announced the appointment of Dr. Arnold Levine to the company's board of directors. Dr. Levine brings to GeneCentric a wealth of experience related to the life sciences, and status as a prominent inventor in the field of molecular biology.

"I am pleased to join the GeneCentric Board at this important time for both the company and personalized oncology," said Dr. Levine. "GeneCentric has brought together world leaders in cancer research and diagnostics. They have made tremendous progress in a very short amount of time to advance the development of novel, targeted assays that enable oncologists make more informed, individualized, therapy decisions."

Dr. Levine is a widely acclaimed leader in cancer research. In 1979, Levine and others discovered the p53 tumor suppressor protein, a molecule that inhibits tumor development. Dr. Levine previously served as President and Chief Executive Officer of Rockefeller University from 1998 to 2002 and was the Harry C. Weiss Professor of the Life Sciences and Chairman of the Molecular Biology Department at Princeton University from 1984 to 1998. He established the Simons Center for Systems Biology at the Institute for Advanced Study, which concentrates on research at the interface of molecular biology and the physical sciences: on genetics and genomics, polymorphisms and molecular aspects of evolution, signal transduction pathways and networks, stress responses, and pharmacogenomics in cancer biology.

"We are excited to have Dr. Levine join the GeneCentric board. HIs vast experience will help drive the GeneCentric scientific vision and strategy," said Clay Thorp, General Partner at Hatteras Venture Partners and Chairman of GeneCentric. "The addition of Dr. Levine further validates both the company's scientific and development strategies."

GeneCentric was co-founded in 2011 by two pioneers in cancer research, Drs. Charles Perou and Neil Hayes, who discovered molecular signatures critical in distinguishing clinically relevant subtypes of lung cancer. GeneCentric in-licensed from UNC-CH these technologies, known as the Lung Subtype Platform (LSP), and the Hypoxia Signature for diagnosing risk of cancer metastasis, and Hatteras Venture Partners provided the founding Series I financing. GeneCentric is led by Dr. Myla Lai-Goldman, former CMO & CSO of Laboratory Corporation of America, Holdings (LabCorp) and current Venture Partner at Hatteras Venture Partners.

About GeneCentric

GeneCentric Diagnostics, Inc, based in Durham, NC, is a molecular diagnostic company which develops and commercializes novel assays that enable oncologists and their patients make more informed treatment decisions. For more information, please visit: http://www.genecentric.com

Contact:

Myla Lai-Goldman myla@genecentric.com

Read more here:
Dr. Arnold Levine Joins GeneCentric Board of Directors

With topics like Transvaginal Mesh, ADHD, Asthma, Irritable Bowel, Diabetes, DVT, and GERD, Audio-Digest Foundation …

Audio-Digest Foundation, the largest independent publisher of Continuing Medical Education in the world, is releasing free written summaries of its anesthesiology, emergency medicine, family practice, gastroenterology, general surgery, internal medicine, neurology, obstetrics/gynecology, oncology, ophthalmology, orthopaedics, otolaryngology, pediatrics, psychology, and urology programs via Amazon Kindle.

Glendale, CA (PRWEB) September 27, 2012

Anesthesiology Continuing Medical Education: What's Old And What's New In Pediatric Anesthesiology to improve the management of anesthesia for children with sleep disorders and sickle cell disease.

Emergency Medicine Continuing Medical Education: Malpractice Prophylaxis to prevent malpractice and related lawsuits.

Family Medicine Continuing Medical Education: Common Concerns In Women to improve management of asthma in children.

Family Practice Continuing Medical Education: Treating Gi Disease: Minimizing Risks And Enhancing Benefits to improve management of acute and chronic kidney disease.

Gastroenterology Continuing Medical Education: Endoscopy Review to improve the medical, surgical, and nutritional management of inflammatory bowel disease (IBD).

General Surgery Continuing Medical Education: Medical Errors/The Future Of Surgery to improve management of conditions affecting the gastrointestinal tract, including perforated and nonperforated peptic ulcers, nonerosive reflux disease, and disorders of gastric empyting.

Audio-Digest Internal Medicine Continuing Medical Education: Current Concepts In Infectious Disease Management to improve the diagnosis and management of ophthalmic conditions and the prevention of microvascular complications in patients with diabetes mellitus (DM).

Internal Medicine Continuing Medical Education: Update On Asthma to improve prevention, diagnosis, and treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE).

Follow this link:
With topics like Transvaginal Mesh, ADHD, Asthma, Irritable Bowel, Diabetes, DVT, and GERD, Audio-Digest Foundation ...

With topics like Trauma, Asthma, COPD, Vitamin D, PXF, Kidney Cancer, and Meniere's Disease, Audio-Digest Foundation …

Audio-Digest Foundation, the largest independent publisher of Continuing Medical Education in the world, is releasing free written summaries of its anesthesiology, emergency medicine, family practice, gastroenterology, general surgery, internal medicine, neurology, obstetrics/gynecology, oncology, ophthalmology, orthopaedics, otolaryngology, pediatrics, psychology, and urology programs via Amazon Kindle.

Glendale, CA (PRWEB) September 28, 2012

Anesthesiology Continuing Medical Education: Trauma, Urgent Care, And Patient Safety to improve perioperative management of cardiac surgery patients, to review procedures for ensuring patient saftey, and to raise awareness of issues of cost containment in trauma and critical care.

Emergency Medicine Continuing Medical Education: Geriatric Emergencies to recognize and improve the management of altered mental states in the elderly and the unique risks that elderly patients present in the emergency department (ED).

Family Medicine Continuing Medical Education: What's New In Pediatric Asthma to reduce the incidence of healthcare-associated infections (HCAIs).

Family Practice Continuing Medical Education: Essentials Of Nephrology to improve the outcomes of smoking cessation therapies and the management of chronic obstructive pulmonary disease (COPD).

Audio-Digest Gastroenterology Continuing Medical Education: Sources Of Gastrointestinal Pain to improve the management of gastroparesis and postinfectious gastrointestinal disease.

Audio-Digest General Surgery Continuing Medical Education: Bread And Butter Surgery to improve clinical practice by providing clinicians with information about the functioning of corporate boards, accredited medical staff, and pay-for-performance programs.

Audio-Digest Internal Medicine Continuing Medical Education: Expert Advice: Vitamin D/Dermatology to improve the diagnosis and management of somatization and the assessment of depression and anxiety in the primary care setting.

Internal Medicine Continuing Medical Education: Topics In Gastroenterology to improve the diagnosis and management of nontuberculous mycobacterial (NTM) diseases and interstitial lung diseases (ILDs).

Visit link:
With topics like Trauma, Asthma, COPD, Vitamin D, PXF, Kidney Cancer, and Meniere's Disease, Audio-Digest Foundation ...

With topics like hemorrahe, neonatal disorders, atrial fibrillation, IBS, and dyspepsia, Audio-Digest Foundation …

Audio-Digest Foundation, the largest independent publisher of Continuing Medical Education in the world, is releasing free written summaries of its anesthesiology, emergency medicine, family practice, gastroenterology, general surgery, internal medicine, neurology, obstetrics/gynecology, oncology, ophthalmology, orthopaedics, otolaryngology, pediatrics, psychology, and urology programs via Amazon Kindle.

Glendale, CA (PRWEB) September 29, 2012

Anesthesiology Continuing Medical Education: Forthcoming Issues In Clinical Anesthesia to improve judicious use of anesthesia by reviewing the evidence about neurotoxicity and predictions of future trends in anesthesia care.

Emergency Medicine Continuing Medical Education: Trauma In 2009 to improve the management of simple wounds, resuscitation and management of victims of combat trauma, and hemorrhage control.

Family Medicine Continuing Medical Education: Improving Control Of Health Care-Associated Infections to improve the diagnosis and management of neonatal disorders and developmental delay in children.

Family Practice Continuing Medical Education: Threats To Lung Function: What Can We Do About Them? to improve management of coronary artery disease and atrial fibrillation (AF).

Gastroenterology Continuing Medical Education: Recurrence And Nutrition In Ibd to improve the management of Helicobacter pylori infection and irritable bowel syndrome.

General Surgery Continuing Medical Education: Issues In Endocrine Surgery to improve the management of patients requiring trauma resuscitation.

Audio-Digest Internal Medicine Continuing Medical Education: Issues In Cardiorenal Medicine to improve management of cancer through personalization of treatment, and to improve care of breast cancer survivors.

Internal Medicine Continuing Medical Education: From Awareness To Prevention to improve the diagnosis and management of diverticular disease, dyspepsia, and Clostridium difficile colitis.

Read more:
With topics like hemorrahe, neonatal disorders, atrial fibrillation, IBS, and dyspepsia, Audio-Digest Foundation ...

With topics like Anorexia, Bulimia, Immunizaion, Malpractice, Scoliosis, Melanoma, Psychosis, Audio-Digest Foundation …

Audio-Digest Foundation, the largest independent publisher of Continuing Medical Education in the world, is releasing free written summaries of its anesthesiology, emergency medicine, family practice, gastroenterology, general surgery, internal medicine, neurology, obstetrics/gynecology, oncology, ophthalmology, orthopaedics, otolaryngology, pediatrics, psychology, and urology programs via Amazon Kindle.

Glendale, CA (PRWEB) September 30, 2012

Anesthesiology Continuing Medical Education: Preoperative Evaluation: Who Should Do It? to improve preoperative evaluations.

Emergency Medicine Continuing Medical Education: Drug Review 2009 to improve management of patients treated in the emergency department (ED).

Family Medicine Continuing Medical Education: Less Than Perfect: Diseases And Disorders Of Early Life to improve management of patients after gastric bypass surgery and those with anorexia or bulimia.

Family Practice Continuing Medical Education: Cardiovascular Disease: Concepts In Management to improve immunization practice in primary care medicine.

Audio-Digest Gastroenterology Continuing Medical Education: Stomach And Intestinal Issues to improve the management of liver disease in children.

Audio-Digest General Surgery Continuing Medical Education: Advances In The Treatment Of Colorectal Disease to improve management of scoliosis and cranial deformities.

Audio-Digest Internal Medicine Continuing Medical Education: Thromboembolism to promote practices that decrease the likelihood of malpractice litigation and improve management of disruptive or eccentric behavior in health care personnel.

Internal Medicine Continuing Medical Education: Topics In Mental Health to improve the diagnostic work-up of the patient with syncope and the identification and management of uncommon headache syndromes.

See the article here:
With topics like Anorexia, Bulimia, Immunizaion, Malpractice, Scoliosis, Melanoma, Psychosis, Audio-Digest Foundation ...

BIONOVA Skincare: Customization and Life Science Nanotechnology.

NEW YORK, Sept. 24, 2012 /PRNewswire/ --

Importance of Age Groups BIONOVA, a pioneer brand based on Life Science Nanotechnology, offers customization based on Human physiology. As a result, there are no more same skincare products for Mothers and Daughters, Fathers and Sons even if they have identical skin concerns. Age is a very important criterion that affects general metabolism, speed of biochemical processes on a cellular level, hormonal balance, self-healing ability and much more.

(Logo: http://photos.prnewswire.com/prnh/20120229/NY59364LOGO )

(Photo: http://photos.prnewswire.com/prnh/20110207/NY43170-b )

Power of Nanotechnological approachToday, personal trainer, personal diet became a common feature in our daily life. BIONOVA brought the same personal approach to the skin care by offering the N1-CUSTOM line. This line covers all criteria that effect skin function such as: Gender, Age, Ethnic background, Weight, and even the Weather condition. The technological ability composing NANO-COMPLEXES depending on a customer's Personal profile offers a solution to practically any skin concern.

The efficacy of BIONOVA products is determined by using NANO-COMPLEXES. Each NANO-COMPLEXES contains from 80 to 100 bioactive ingredients. It is remarkable that all these ingredients come in the same tiny quantities (Nano and Pico) as found in a human body. Due to this fact, the skin easily recognizes and absorbs what it needs to restore its normal functioning.

Unique business modelThe doctor's designed questionnaire is so precise that chances of formula repetition are 1 in 60 million! The unique proprietary database and software translate all answers into a formula. BIONOVA's lab technicians make a product from scratch as soon as it appears on the lab monitor. After making a product, it takes 12 hrs to reach equilibrium of NANO-COMPLEXES and after that the product is ready for shipment to any place in the world.

Future of Life Science NanotechnologyEach Century brings its new spin on any aspect of our lives. Life Science Nanotechnology is the next step in Skin Care and other Life Science disciplines: pharmaceutical and nutrition. Very soon, we will be able to customize our own medication and nutrition supplements. The ability to compose NANO-COMPLEXES allows gently, without interrupting the natural processes to assist the body to restore broken informational links. Life Science Nanotechnology is the future of life science disciplines for it's most logical, harmonious and healthy to the human body way.

Available Topic Expert(s): For information on the listed expert(s), click appropriate link. Dr. Michael Danielov http://www.profnetconnect.com/bionovalab.com

More:
BIONOVA Skincare: Customization and Life Science Nanotechnology.

On medical school entrance exam, students get early start to stay ahead

Amy Li 14 had two summer jobs, but her work did not end when she went home for the day. She spent half of her summer at a clinical internship in Alabama and the other half on campus doing molecular biology research.

Li was also registered to take the Medical College Admissions Test in September, so she spent her nights self-studying biology, chemistry, biochemistry and anatomy.

I wanted to study for the MCAT, but at the same time I didnt want to lose a valuable summer for clinical work or research, Li said. So I decided to just work really hard and try to do both.

Li is among a group of students who choose to take the MCAT the summer before their junior years. To these students, that summer is the perfect time to study for and take the five-hour test, which covers diverse topics including biology, organic and general chemistry, physics and anatomy and is a critical part of a students application to medical school.

Premedical students often factor studying for the test into their workloads and extracurricular options, according to Health Professions Advising director Kate Fukawa-Connelly.

You always have to take into account what youre going to be doing when you take the MCAT, Fukawa-Connelly says. If youre taking it your senior year, you have to plan your two-course semester and your thesis work with preparation for the MCAT in mind.

Li said that for students who want to go straight to medical school, the summer before junior year is an ideal time to devote to studying for the test. These students then spend their junior years focusing on schoolwork before beginning their application processes in the summer and fall of their senior years.

Its good to get it out of the way at a time thats most convenient, because you can dedicate an entire summer to studying and then focus on schoolwork during the year, Li said. It makes the most sense.

Patricia Yeh 14 also studied for and took the test this summer. Matriculating at medical school immediately after graduation was her biggest priority, she said, so in the course of planning activities for her summer, she made sure she had time to study.

I knew studying would be the most time-consuming activity I had, so I was volunteering a fair amount, but not enough to deter me from studying, she said.

Visit link:
On medical school entrance exam, students get early start to stay ahead

A Community Success Story: Combining Public and Private Sectors for Health Care and Education

How a local government, university, hospital, medical school, non-profit, and corporation in Bethlehem, Pennslyvania are working together in an approach to education that encompasses health and well-being.

Just getting to school each day, for the students of Broughal Middle School in the south side of Bethlehem, PA, was a strike against their ability to achieve in the classroom.

When undergrads from Lehigh University spent a week following students to and from school with hand-held devices that measure air pollutants, they found that the kids' daily walks could be contributing to the high rates of asthma that were keeping them out of the classroom.

Redirecting their path through the major intersections of downtown Bethlehem, the city joined forces with community partners to repurpose an old railroad line into a safer path to school. It's lined with trees, ends half a block away from Broughal's front doors, and, if those hand-held monitors are to be believed, contains significantly cleaner air.

Such are the small changes that the national community school initiative aims to bring about, aided by mutually beneficial partnerships. "We think that health and education go together," said Martin Blank, President of Institute for Educational Leadership and Director of the Coalition for Community Schools. "While some people in the education reform business don't want to acknowledge the linkage -- they think it's all academic -- the reality is that kids who are sick miss school time." Among other initiatives, the Coalition works closely with the National Assembly for School-Based Health Care to address the high rates of chronic absence that often occur in areas where diseases like asthma are common among students and good primary care is unavailable to them.

In Bethlehem, the government (the department of Parks and Recreation), the university (Lehigh), the hospital (St. Luke's), the medical school (the St. Luke's campus of Temple University), a non-profit (the United Way of Greater Lehigh Valley), and a locally-owned corporate sponsor (Just Born, Inc) work together on goals tailored to the community's unique needs, and to the willingness of its partners to help meet them. With the public school as its hub, the partnership focuses everyone's efforts on common goals.

"If kids are growing up in an environment where they are healthy and eating well, and where their parents are committed to their own growth and development, and have opportunities for good jobs, the chances of our students being able to learn better go up significantly," said Dr. George White, Iacocca Professor of Educational Leadership and Director of Center for Developing Urban Educational Leaders (CDUEL) at Lehigh University.

The community health initiative is only one part of the larger project, which also emphasizes literacy and numeracy and adult education and job training. And the Greenway, as they're calling the new route to school, arose from the simple realization that students can't thrive if their basic health needs aren't met. The students, 94 percent of whom qualify for free or reduced lunch and many of whom are at a high risk of diabetes, are also benefiting from healthier meals. Their breakfasts and lunches -- along with the community's two new farmer's markets -- include items grown in the after-school organic gardening club's greenhouse, which itself will soon be supporting by a composting program via Lehigh's engineering department. A fitness center is open both before and after school. According to Blank, schools often work to integrate such practical health education into their classroom curriculum.

There's also a dental office right in the school building -- twice a month, St. Luke's sends a dentist to perform fillings and extractions. The community college, for its part, sends over people from its dental hygienist program for cleanings. Once a month on Saturdays (and soon to be twice a month) for the past year and a half, the Temple University medical students have run a free clinic for un- and under-insured families. The school provides the space, physicians volunteer their time, and undergraduates at Lehigh who are just starting to explore the field of medicine are trained to work as "health coaches." The students follow-up with patients by giving them rides to pick up their medication, for example, or showing them how to use blood pressure cuffs.

"It's not just do-gooder work," said White. "In each of these cases, the partners gain as much as they give." The medical students, for example, get valuable real-world experience from their work at the clinic. In the long-term, the hope is that the wellness initiative's focus on prevention and healthy lifestyles will strengthen the health of the overall community. The potential benefits for all of Bethlehem are wide-ranging.

Read more from the original source:
A Community Success Story: Combining Public and Private Sectors for Health Care and Education

WC medical school training doctors of osteopathy

COURTESY WILLIAM CAREY UNIVERSITYThird-year medical students Shanique Jarrett of Gainesville, Fla., and Alaukik Bhasin of Columbia study the structures of the human face at the William Carey University College of Osteopathic Medicine.

HATTIESBURG -- Brent Arnold was planning to get his doctorate in biomedical engineering from Louisiana Tech University in Ruston, La., but in his senior year he decided he wanted to be a doctor and work directly with patients rather than doing research.

Arnold enrolled in the first class at William Carey University's College of Osteopathic Medicine and this year will begin his clinical rotations. After that, he will do an internship and residency before he begins practicing as a doctor of osteopathy, or a DO.

"William Carey is close to home and close to family," said Arnold, a native of Alexandria, La. "I want to practice in the South."

The medical school, or COM as it's known, was supposed to open in 2005, but Hurricane Katrina interrupted those plans.

"We were first contacted by the state osteopathic medical association about opening a school, but we didn't know a lot about osteopathic medicine," said Tommy King, president of William Carey. "The more we learned, the more it fit in with the mission of the university."

Osteopathic doctors are known for their "whole person" approach to medicine, rather than just treating symptoms. They focus on preventive health care and natural treatment rather than medicine, although they can prescribe medication.

"It's the osteopathic emphasis on the holistic approach that we liked," said Darrell Lovins, dean of the medical school. "We treat the whole person."

King said that 76 of Mississippi's 82 counties are considered medically underserved, and the university wanted to provide more medical care to areas of the state that need it.

"We had investors ready to put up the money, but then Katrina hit," he said. "We were preoccupied with recovery from Katrina, but when we got on our feet, we started thinking about it again."

Go here to read the rest:
WC medical school training doctors of osteopathy

UMass Med professors are sleuths of the genome

WORCESTER Two professors at the University of Massachusetts Medical School are playing a role in a global effort to unlock the mysteries of the human genome, which is the complete set of genetic instructions for humans.

Medical school professors Job Dekker and Zhiping Weng participated in an international consortium of scientists from 32 institutions that made headlines this month with its findings. The scientists involved in the Encyclopedia of DNA Elements project, or ENCODE, announced that parts of the genome often dismissed in the past as junk DNA actually play an important role in regulating what genes do.

Through the projects research, scientists have gained an understanding of 80.4 percent of the human genome, the UMass Medical School professors said.

That is a tremendous improvement in our understanding of the genome, said Mr. Dekker, who holds a doctorate and is professor of biochemistry and molecular pharmacology and co-director of the schools Systems Biology program.

Researchers involved in the project used a range of experimental approaches to understand what pieces of DNA are regulating genes. The research labs of Mr. Dekker and Ms. Weng, who holds a doctorate and is the director of the medical schools program in bioinformatics and integrative biology, worked on separate projects that contributed to the effort.

The findings of the international project appeared in 30 papers published in the journals Nature, Genome Research and Genome Biology. Mr. Dekker was the lead author of one of the Nature papers. The results of Ms. Wengs efforts were published in Genome Research. The consortiums work received funding from the National Human Genome Research Institute, part of the National Institutes of Health.

The professors touted the data produced by ENCODE which built upon the Human Genome Project completed in 2003 as the basis for further study in the genetic causes of human disease and a potential boon for pharmaceutical and other medical research.

For the past decade, Mr. Dekker has helped develop methods to create three-dimensional models of folded chromosomes. Those models can be used to determine which parts of the genome touch each other, according to the medical school.

Scientists have believed for a number of years that a regulatory element could control a gene by physically interacting with that gene, Mr. Dekker said. His goal is to measure the three-dimensional structure to see which regulatory elements physically touch what genes, he said.

We have gone from this view of the genome where we have here and there a gene and then large sections of unknown of territory, Mr. Dekker said. We now have a much richer picture of the genome, where we can see genes, and we can set lots and lots of these regulatory elements.

Go here to see the original:
UMass Med professors are sleuths of the genome

Joslin Scientists Identify Molecular Process in Fat Cells That Influences Stress and Longevity

Newswise BOSTON September 16, 2012 As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor microRNA processing in fat tissue which plays a major role in aging and stress resistance. This finding may lead to the development of treatments that increase stress resistance and longevity and improve metabolism. The findings appear in the September 5 online edition of Cell Metabolism.

Over the past several years, it has become clear that fat cells (adipocytes) are more than just repositories to store fat. Indeed, fat cells secrete a number of substances that actively influence metabolism and systemic inflammation. Previous studies have found that reducing fat mass by caloric restriction (CR) or surgical or genetic means can promote longevity and stress resistance in species from yeast to primates. However, little is known about how CR and fat reduction produce these beneficial effects. This study investigated one type of molecular mediator change in microRNAs (miRNAs) and the processing enzymes required to make them that is influenced by aging and reversed by caloric restriction. miRNAs are involved in the formation of mature RNA.

Based on studies conducted using human cells, mice and C. elegans (a microscopic worm used as a model organism for aging studies), the researchers demonstrated that levels of multiple miRNAs, decrease in fat tissue (adipose) with age in all three species. This is due to a decrease in the critical enzyme required from converted pre-miRNAs to mature miRNAs, Dicer. In the human study, which compared the miRNA levels in preadipocytes (fat cell precusors) of young, middle-aged and older people, people aged 70 and older had the lowest miRNA levels. The fact that this change occurs in humans, mice and worms points to its significance as a general and important process, says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

Caloric restriction, which has been shown to prolong lifespan and improve stress resistance in both mice and worms, prevents this decline of Dicer, and in the case of the mice, restore miRNAs to levels observed in young mice. Conversely, exposure of adipocytes to major stressors associated with aging and metabolic diseases, including toxic agents, Dicer levels decreased. Mice and worms engineered to have decreased Dicer expression in fat showed increased sensitivity to stress, a sign of premature aging. By contrast, worms engineered to overexpress Dicer in the intestine (the adipose tissue equivalent in worms) had greater stress resistance and lived longer.

Overall, these studies showed that regulation of miRNA processing in adipose-related tissues plays an important role in longevity and an organisms ability to respond to age-related and environmental stress. This study points to a completely new mechanism by which fat might affect lifespan and is the first time that anyone has looked at fat and miRNAs as factors in longevity, according to co-author T. Keith Blackwell, MD, PhD, co-head of Joslin's Section on Islet Cell and Regenerative Biology and Professor of Pathology at Harvard Medical School.

Based on this study, Blackwell suggests that finding ways to improve miRNA processing to keep miRNA levels up during aging might have a role in protecting against the stresses of everyday life and the development of age- and stress-related disease.

Dr. Kahn and the study investigators are currently working on ways to genetically control Dicer levels in the fat tissues of mice, to create mouse models that are more or less resistant to stress. We would love to find drugs that would mimic this genetic manipulation to produce a beneficial effect, says Dr. Kahn. If we can better understand the biology of aging, we might also understand how age impacts diabetes, says Kahn.

Study co-authors include Marcelo A. Mori, Prashant Raghavan, Jeremie Boucher, Stacey Robida-Stubbs, Yazmin Macotela, Steven J. Russell, and T. Keith Blackwell of Joslin; and James L. Kirkland and Thomas Thomou of the Mayo Clinic.

About Joslin Diabetes Center

Joslin Diabetes Center, located in Boston, Massachusetts, is the world's largest diabetes research and clinical care organization. Joslin is dedicated to ensuring that people with diabetes live long, healthy lives and offers real hope and progress toward diabetes prevention and a cure. Joslin is an independent, nonprofit institution affiliated with Harvard Medical School.

Go here to read the rest:
Joslin Scientists Identify Molecular Process in Fat Cells That Influences Stress and Longevity

Natures Elements Releases New Product: Reishi Mushroom – This Chinese Longevity Mushroom Has Miraculous Health Benefits

Natures Elements, an online vitamin and herbal supplement retailer, has just released Reishi Mushroom (also know as Ling Zhi or Ganoderma Lucidum). This powerful Red Reishi Mushroom is often referred to as the mushroom of immortality because of all its amazing benefits.

Lindenhurst, NY (PRWEB) September 29, 2012

Reishi mushroom has been used in Traditional Chinese Medicine for over 2,000 years making it one of the oldest mushrooms used medicinally as well as one of the most scientifically researched herbs on the planet. Because of all the presumed health benefits and apparent absence of side effects, Reishi Mushroom has attained the reputation of being the ultimate longevity herb.

Not all Reishi Mushroom products are created equal. As with any new product, Natures Elements strives to offer the best and most potent supplements for the consumers maximum results. This is of course true with the new Reishi Mushroom. Natures Elements continues to stress the importance of reading and understanding the supplement facts. Any product can be labeled Reishi Mushroom, but there are at least 3 things to know when buying Reishi Mushroom.

First and foremost, observe the label. Now that the benefits of what Reishi Mushroom provides is clear, it is important to check that the Reishi Mushroom being offered contains a powerful enough dosage to ensure real results. A concentrated 10:1 extract of Reishi Mushroom offers the purest and most potent form.

Secondly, make sure there is enough 10:1 extract of Reishi Mushroom in each dose. The dosage should be at least 1,000 mg, which is usually split between two 500 mg tablets. Lastly the product should have enough supply to last one month, this is important when comparing price.

Natures Elements is one of the few companies around that makes is easy for customers to feel safe and securing by knowing what they are getting. They also offer the convenience of Auto-Ship, which provides automatic monthly shipping with the advantage of receiving 20% off.

Natures Elements is committed to delivering high quality vitamin and herbal supplements and providing real results through dedicated research and superior formulas.

Marketing Department Natures Elements, Inc. 877-223-2626 Email Information

See the rest here:
Natures Elements Releases New Product: Reishi Mushroom - This Chinese Longevity Mushroom Has Miraculous Health Benefits

Mind as Medicine: Retreat Brings Healing, Growth

TEL AVIV, Israel, Sept.25, 2012 /PRNewswire/ -- More than 100 people attended a recent meditation retreat in Tel Aviv, Israel: Physicians, journalists, holistic practitioners, cancer patients and meditation enthusiasts. They came to learn holistic, mind-body approaches to healing and find avenues to spiritual growth. The retreat was led by integrative medicine pioneer and meditation expert Isaac Eliaz, M.D., L.Ac. and was coordinated by Taatsumot, a non-profit organization. The in-depth, two-day retreat program focused on the mind's innate healing power.

Open Heart Healing "The theme of my retreat is connectivity and having an open heart," says Dr. Eliaz. "The heart has no concepts. It's our mind, our negative emotions, our thought patterns that put up barriers and don't allow our heart to just open. Real healing begins, continues and ends with an open heart."

One of the exercises that the group practiced was a form of meditation called Tonglin, during which participants "take in" suffering and generate love and compassion in return. The process allowed people to step outside their natural barriers, such as reluctance to interact with "negative" energy. However, as people overcame their fears, they embraced the practice and found it transformative.

During the retreat, Dr. Eliaz offered hands-on healing to participants while they were meditating, and taught them how to use meditation to heal themselves and others. Throughout the retreat, he answered questions and discussed related topics such as nutrition, natural cancer treatments, mind-body exercises, lifestyle approaches and other subjects.

Mind-Body Connections Dr. Eliaz's diverse background in Western and Eastern medicine, meditation, biomedical research and other disciplines gives him the ability to draw important connections between seemingly unrelated areas -- such as cellular biology, cancer metabolism and meditation. The results were palpable.

"For many people, this retreat was remarkable," says Dr. Eliaz. "There was a person with cancer who had trouble sitting and walking. During the retreat he was able to sit for a long time, and by the end of the program, he had less trouble walking. It's not that everyone heals completely from their physical ailments, but with these practices, everyone can have the potential to heal which translates into a deeper healing on all levels."

The Ripple Effect Though the retreat is over, Dr. Eliaz hopes the healing extends beyond this workshop. "Many practitioners have emailed saying that they are already practicing what they learned at the retreat," says Dr. Eliaz. "When you affect a doctor, you're affecting everybody they work with."

This retreat was so successful, Dr. Eliaz will be going back to facilitate a second three day retreat in Israel from November 1-3, 2012.

"Meditation retreats are my passion. It's an offering, especially in Israel. I feel both obligated and privileged to be able to reach people in this way."

Meditation Retreats and Classes Dr. Eliaz spent his formative years in Israel before moving to Northern California, where he founded the holistic clinic, Amitabha Medical Clinic and Healing Center. He specializes in the integrative treatment of cancer and chronic illness, drawing on his extensive training across a diverse range of medical disciplines. As a meditation practitioner with over 30 years of experience, Dr. Eliaz holds regular meditation and healing retreats and classes for patients, practitioners and anyone interested in mind-body medicine. Visit http://www.BetterHealthPublishing.comto learn more about Dr. Eliaz's upcoming retreat scheduled April, 2013 in California.

View post:
Mind as Medicine: Retreat Brings Healing, Growth

MILITARY: PTSD reduced with integrative medicine, Scripps Health study finds

Camp Pendleton Marines returning from overseas assignments with the psychological scars of combat have been helped with treatment by Scripps Healthresearchers, according to a new study.

The researchers treated active-duty Marines who had post-traumatic stress disorder with what is calledcomplementary and integrative medicine. Marines treated with the complementary methods, called "guided imagery" and "healing touch," showed significantly more recovery than a control group who didn't receive the treatment.

Results were published in the journalMilitary Medicine.

Those with PTSD can experience flashbacks to combat situations, nightmares, depression, feelings of hopelessness and emotional numbness.

A total of 123 active-duty Marines were studied, including 68 who received the complementary approaches along with treatment as usual. The other 55 received only the regular treatment.

Symptoms of those treated with the complementary methods dropped by more than 13 points on an 85-point scale that measures PTSD. The difference was enough to drop the average score of those treated below the level indicating PTSD.

Symptoms of the control group dropped by fewer than 5 points, with the average score remaining above the level indicating PTSD.

Study researchers wereMimi Guarneri, M.D., andRauni King, founders of the Scripps Center for Integrative Medicine.

Guarneri said the study demonstrated very strong statistical significance. The study reported that results had a probabilityof being due to chance of less than 1/20 of 1 percent. A value of 5 percent or less is generally considered statistically significant.

Although the methods may be useful for quickly reducing the suffering of returning soldiers, the study's authors said further research on their long-term effects is needed.

View original post here:
MILITARY: PTSD reduced with integrative medicine, Scripps Health study finds

What nightmares may come, when we shuffle onto an immortal coil

Sunday, Sep. 30, 2012

"In 20 years human beings will neither die nor age."

That's Shukan Gendai magazine's headline. Is it possible? Is the age-old dream about to come true? Are homo sapiens, who have been dying for 190,000-odd years, on the cusp at last of immortality?

Myriad champions down the millennia have waged their battles against Death. The first known one is Gilgamesh, of the 4,000-year-old Mesopotamian epic that bears his name. Gilgamesh, King of Uruk, journeys to a distant land where dwells the world's only immortal man who is willing to help, on one condition: Gilgamesh must stay awake for a week. He fails, and earns a stinging rebuke: "Behold this fellow who seeks eternal life! Sleep swirls over him like a mist."

So much for that. Gilgamesh died but his quest lives on. His successors are legion. Among them is the Chinese Taoist sage Xu Fu, who in the 3rd century BC led an armada of 60 ships crewed, it was said, by 3,000 virgins across the eastern seas in search of the elixir of eternal life. What he found instead, says legend, is Japan, where, legendarily, he settled and introduced the Japanese to rice farming.

There's no end of marvelous tales. Some, to the modern sensibility, are plain crazy, like that of the 16th-century Hungarian noblewoman who pursued deathless eternal youth by bathing in her young daughter's blood. They all have the same ending, which the Biblical Book of Genesis sums up very well: "Dust thou art, and unto dust shalt thou return."

So what is Shukan Gendai telling us that our death sentence has been revoked?

If it has, the hero of this story is not a warrior-king or a mystic or a quack but a scientist. His thesis arouses more skepticism among his peers than support, but over the years the support has been growing, if slowly. He's a 49-year-old British biogerontologist named Aubrey de Grey. He has a doctorate from Cambridge, is editor in chief of the academic journal Rejuvenation Research, has authored numerous books on aging, and is chief science officer of the SENS Foundation. SENS stands for Strategies for Engineered Negligible Senescence. The last two words are, to all practical purposes, synonymous with immortality.

De Grey works at the cellular level. His famous "seven causes" of aging and death all have to do with cell damage and cell deterioration, and amounts to this: We age because our cells do. Cell deterioration, he believes, can be retarded; cell damage can be repaired. The SENS Foundation has been pursuing this modern elixir of youth for 20 years. De Grey figures another 20 years should do it. We're almost there. Think of the implications: many people now living will never die.

When he started, the consensus was that de Grey was a crank. Support even now is cautious and qualified. Shukan Gendai quotes several Japanese experts who agree that cellular rejuvenation is theoretically possible, though they question whether that will necessarily lead to immortality or even to a much extended youthfulness. De Grey, undaunted, invites us to imagine a world transformed. We'll get old without it mattering. The young will look up to us for our experience and wisdom, instead of down on us for our infirmity and dementia and the drain we are on the economy. We'll need neither nursing homes nor final resting places, since there'll be no final rest. Death, shadow on our lives since our species emerged into consciousness, will shadow it no longer.

Follow this link:
What nightmares may come, when we shuffle onto an immortal coil

John Silber and Immortality

Today is a day for John Silbers detractors to put their pens down. John Silber is dead, and he was a great man in the sense of how human beings long were measuredby their accomplishments.

In many ways he was the exact opposite of the famously self-referential Milan Kundera, whose own thinking was summed up nicely in his novel Immortality:

While hypnotic, that obsession with self-reference is a recipe for hyper-sensitivity, resentments, and all-too-much navel-gazing, the kind that we require of our students all too often as they learn to write. We have them write about their feelings, their observations, their observations about their feelings, and maybe even their observations about others observations about their feelings.

For John Silber that was a disasterin some ways the disaster of American education.

Some may think that Silbers brusqueness was all about shunning peoples feelings. Back in 2008, when the Massachusetts Board of Education spent successive meetings seeking nicer ways to speak about school failure, hoping to soften even the already fluffy underperforming by calling them a Commonwealth priority, Silber thundered:

The newspapers delighted in such quotes. But the fact is that Silber was interested in attaching the right word to the right object or the right idea. He is called the architect of the MCAS in todays Globe, but the fact is that he thought that any useful test was good even the Stanford 9. (He was wrong on that, BTW.) What he really is the architect of is the broader set of education reforms that set this state on a path focused on academics rather than simple skills or self-esteem. He believed in knowledge acquisition and thereafter the formulation of an individuals judgment.

Tests were a vehicle to inject this into a system that was failing spectacularly. Like so many in the state, when Silber started as Chairman of the Board of Education in Massachusetts, he was not a fan of charter schools. He thought he would by dint of personality and force of will turn around the state's entire network of district schools. And he aimed to do it by focusing on academics, higher-quality teaching (ensured through subject/contentbased tests rather than the usual PRAXIS tests employed in other states) and an accountability/audit office for the public schools that was to mirror the British system.

Those were difficult times for such an argument. After all, the Board of Education was, prior to his arrival, a place where debates about whether to include Ebonics in the states content standards took considerable air time. He was appointed in 1996 by his former rival for Governor, William Weld, to chair the states Board of Education. That appointment had the support of both the Senate President and the Speaker of the House, because they were disappointed with the pace of reform after the Commonwealths 1993 landmark Education Reform law.

All three of these elected leaders got what they were looking for: An energetic, focused educational leader who was willing to do what it took to shake up the education establishment and bureaucracy.

More:
John Silber and Immortality

Mass. health official says West Nile virus all over the state

State health officials are warning residents to protect themselves from mosquito bites as more cases of West Nile virus crop up across the state.

On Wednesday, a Newton woman was recovering from West Nile the fourth confirmed human infection in Massachusetts. While mosquitoes detected with eastern equine encephalitis (EEE) have fallen off slightly, detection of West Nile is on the rise, according to an official at the Department of Public Health.

So far this season, four people have been infected with West Nile, and one with EEE, according to state health officials.

West Nile cases are also on the rise nationally, according to a Department of Public Health official. In Massachusetts, state health officials have found infected mosquitoes in 93 communities.

"Over the last three weeks or so, West Nile has been dramatically increasing," said Dr. Catherine Brown, state public health veterinarian. "It is very high."

Brown said the "bad news" is the number of communities with West Nile-infected mosquitoes could be much higher some communities are not tested. Only communities that are a part of one of the nine mosquito control projects test.

"What this tells us is there is a lot of West Nile everywhere," Brown said. "At this point, people should consider that West Nile virus is present throughout the state."

West Nile virus was first found in Massachusetts in 2000. There were bad outbreaks in 2002-2003, with 22 and 18 human infection cases respectively. Since then, the number of cases hasnt hit those levels, according to Brown.

The summers high temperatures and dry conditions created ideal conditions for mosquito-borne infections.

"The heat, not only does it speed up mosquito reproduction, it also speeds up the virus multiplication. The mosquitoes infect the birds; the birds infect more mosquitoes," Brown said. "That whole cycle between the birds and the mosquitoes is called virus amplification."

Read more:
Mass. health official says West Nile virus all over the state

Researchers develop editing toolkit for customizing zebrafish genomes

ScienceDaily (Sep. 23, 2012) Mayo Clinic researchers and an international team of scientists have developed a highly-efficient means of editing zebrafish genomes for research purposes, eliminating a bottleneck that has stymied biomedical scientists from using the fish as a model for human disease.

The details appear online today in the journal Nature.

For many researchers, zebrafish are becoming the model of choice for genetic studies. However, the inability to efficiently target genetic modifications has delayed their use by some. The Mayo team used an improved variant of artificial transcription activator-like effector nucleases, or TALENs, to provide a new approach.

"By using genetic engineering tools called TALENs and synthetic DNA to make defined changes in the genomes of our fish, we are able to make small changes (just a few nucleotides) as well as add a specific sequence for biological gene switch applications," says Stephen Ekker, Ph.D., senior author and head of Mayo's zebrafish core facility. "This is the first time we've been able to make custom changes to the zebrafish genome."

Dr. Ekker says this toolkit opens the door to a range of new experiments in zebrafish, including modeling of human disease by introducing small point mutations, designing regulated gene alleles, and developing classical structure/function experiments using an animal model system.

This new approach has implications for other model systems, including mice, rats, flies and worms, and possible applications in stem cell research.

"To our knowledge, this TALEN toolkit also is the most active described to date," says Dr. Ekker. "This has important implications for the growing TALEN field, whether used in fish or any other cells. We used this higher activity for genome editing applications. We also used it to conduct a series of somatic gene function assessments, opening the door to an array of non-germline experiments in zebrafish."

Other authors include Victoria Bedell, Jarryd Campbell, Tanya Poshusta, Randall Krug, Sumedha Penheiter, Ph.D., Alvin Ma, Ph.D., and Karl Clark, Ph.D., all of Mayo Clinic; Ying Wang, Ph.D., and Jeffrey Essner, Ph.D., of Iowa State University; Colby Starker, Ph.D., Wenfang Tan, Ph.D., Scott Fahrenkrug, Ph.D., Daniel Carlson, Ph.D., and Daniel Voytas, Ph.D., all of the University of Minnesota; and Anskar Y. H. Leung, M.D., Ph.D., of Queen Mary Hospital, Hong Kong.

Support for the research came from the State of Minnesota, the National Institutes of Health, the National Science Foundation, the Research Grant Council of the University of Hong Kong and the Tang King Yin Research Fund.

Share this story on Facebook, Twitter, and Google:

Continued here:
Researchers develop editing toolkit for customizing zebrafish genomes

Gene clues offer new hope for treating breast cancer

NEW YORK Scientists reported Sunday that they have completed a major analysis of the genetics of breast cancer, finding four major classes of the disease. They hope their work will lead to more effective treatments, perhaps with some drugs already in use.

Don't miss these Health stories

Trampolines are too dangerous for children to use, the American Academy of Pediatrics warned Monday. There were nearly 100,000 trampoline injuries in 2009 -- and safety nets don't offer much protection, doctors say.

The new finding offers hints that one type of breast cancer might be vulnerable to drugs that already work against ovarian cancer.

The study, published online Sunday by the journal Nature, is the latest example of research into the biological details of tumors, rather than focusing primarily on where cancer arises in the body.

The hope is that such research can reveal cancer's genetic weaknesses for better drug targeting.

"With this study, we're one giant step closer to understanding the genetic origins of the four major subtypes of breast cancer," Dr. Matthew Ellis of the Washington University School of Medicine said in a statement. He is a co-leader of the research.

"Now we can investigate which drugs work best for patients based on the genetic profiles of their tumors," he said.

The researchers analyzed DNA of breast cancer tumors from 825 patients, looking for abnormalities. Altogether, they reported, breast cancers appear to fall into four main classes when viewed in this way.

One class showed similarities to ovarian cancers, suggesting it may be driven by similar biological developments.

Read the rest here:
Gene clues offer new hope for treating breast cancer

Researchers discover gene that causes deafness

Public release date: 30-Sep-2012 [ | E-mail | Share ]

Contact: Katie Pence katie.pence@uc.edu 513-558-4561 University of Cincinnati Academic Health Center

CINCINNATIResearchers at the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center have found a new genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1.

These findings, published in the Sept. 30 advance online edition of the journal Nature Genetics, could help researchers develop new therapeutic targets for those at risk for this syndrome.

Partners in the study included the National Institute on Deafness and other Communication Disorders (NIDCD), Baylor College of Medicine and the University of Kentucky.

Usher syndrome is a genetic defect that causes deafness, night-blindness and a loss of peripheral vision through the progressive degeneration of the retina.

"In this study, researchers were able to pinpoint the gene which caused deafness in Usher syndrome type 1 as well as deafness that is not associated with the syndrome through the genetic analysis of 57 humans from Pakistan and Turkey," says Zubair Ahmed, PhD, assistant professor of ophthalmology who conducts research at Cincinnati Children's and is the lead investigator on this study.

Ahmed says that a protein, called CIB2, which binds to calcium within a cell, is associated with deafness in Usher syndrome type 1 and non-syndromic hearing loss.

"To date, mutations affecting CIB2 are the most common and prevalent genetic cause of non-syndromic hearing loss in Pakistan," he says. "However, we have also found another mutation of the protein that contributes to deafness in Turkish populations.

"In animal models, CIB2 is found in the mechanosensory stereocilia of the inner earhair cells, which respond to fluid motion and allow hearing and balance, and in retinal photoreceptor cells, which convert light into electrical signals in the eye, making it possible to see," says Saima Riazuddin, PhD, assistant professor in UC's department of otolaryngology who conducts research at Cincinnati Children's and is co-lead investigator on the study.

See original here:
Researchers discover gene that causes deafness