New medical school student sees chance to serve El Paso

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First year Medical Students Travis Corgan, left, and Christine Dahlhausen wait to don their white coats during the Texas Tech Paul L. Foster School of Medicine White Coat Ceremony at the Plaza Theatre.

El Pasoan Victoria Nuez smiled after putting on her white medical coat for the first time during a ceremony Saturday for the newest class of students at El Paso's medical school.

Nuez is one of the 80 students in the fourth class to enter the Texas Tech University Health Sciences Center Paul L. Foster School of Medicine. Nuez is among 12 El Pasoans in the medical school's Class of 2016.

The new students were given the coats, which are symbolic of the medical profession, during a White Coat Ceremony at the Plaza Theatre. The White Coat Ceremony is a milestone that marks entering the medical field and signifies the responsibility to take care of patients.

Nuez, a graduate of Americas High School and the University of Texas at Austin, said she was happy to attend medical school in her hometown.

"It means so much," Nuez said. "I still have family here. I have that support network from my family. I can give back to my community."

Nuez said she was inspired to become a doctor by her grandfather, Dr. Germinal Nuez, who was a doctor in El Paso before he retired, and her aunt, Dr. Lourdes Nuez of Miami.

Medical school leaders said the new group of students were selected from 2,900 applicants. The school now has 260 students, including the newest class.

The school's first class will graduate next May in what will be a milestone for the medical school, which for decades was only a dream for El Paso, said Dr. J. Manuel de la Rosa, the medical school's founding

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New medical school student sees chance to serve El Paso

Liberty try to move closer to playoff spot

The Liberty have been here before and flopped.

It was June 10 when they hosted the Chicago Sky at the Prudential Center.

The Liberty, after opening the season with five straight losses, had won three straight, the Sky six in a row.

It was a showdown of two of the hottest teams in the WNBA. Chicago won 73-64 with a dominating defensive effort.

Today, its deja vu all over again.

The Liberty (6-9) have won two straight to pull within a game of the Atlanta Dream for the final playoff spot in the Eastern Conference.

Their opponent today is the San Antonio Silver Spurs (10-5), who have won six straight to move into second place in the Western Conference, 2 1/2 games behind the Minnesota Lynx.

The Silver Spurs are led by former Liberty star Becky Hammon. Her return always ratchets up the emotion for Liberty fans.

Hammon is one of the most popular players in team history.

But Hammons return merely is a subplot. The story is whether or not the Liberty can build momentum heading into the second half of the season.

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Liberty try to move closer to playoff spot

Tax man set to police Americans on health insurance

WASHINGTON -- The Supreme Court's decision to uphold most of President Barack Obama's health care law will come home to roost for most taxpayers in about 2 1/2 years, when they'll have to start providing proof on their tax returns that they have health insurance.

That scenario puts the Internal Revenue Service at the center of the debate, renewing questions about whether the agency is capable of policing the health care decisions of millions of people in the United States while also collecting the taxes needed to run the federal government.

Under the law, the IRS will provide tax breaks and incentives to help pay for health insurance and impose penalties on some people who don't buy coverage and on some businesses that don't offer it to employees.

The changes will require new regulations, forms and publications, new computer programs and a big new outreach program to explain it all to taxpayers and tax professionals. Businesses that don't claim an exemption will have to prove they offer health insurance to employees.

The health care law "includes the largest set of tax law changes in more than 20 years," according to the Treasury inspector general who oversees the IRS. The agency will have to hire thousands of workers to manage it, requiring significant budget increases that already are being targeted by congressional Republicans determined to dismantle the president's signature initiative.

"Knowing the complexity of the health law, there's no question

Treasury spokeswoman Sabrina Siddiqui said, "The overwhelming majority of funds used by the agency to implement the Affordable Care Act go to administer the premium tax credits, which will be a tax cut averaging about $4,000 for more than 20 million middle-class people and families."

The Supreme Court, in its 5-4 ruling, upheld the mandate that most Americans get health insurance. The majority said Congress has the power to enforce the mandate under its taxing authority. The decision labeled the penalties a tax, noting that they will be collected by the IRS.

Those who don't get qualified health insurance will be required to pay the penalty -- or tax -- starting for the 2014 tax year, unless they are exempt because of low income, religious beliefs, or because they are members of American Indian tribes.

The penalty will be fully phased in by 2016, when it will be $695 for each uninsured adult or 2.5 percent of family income, whichever is greater, up to $12,500. The nonpartisan Congressional Budget Office estimates that 4 million people will pay the penalty that year.

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Tax man set to police Americans on health insurance

Trenton health care program gives a home to former inmates and patients with mental illnesses

TRENTON At 61 years old, K Ka had spent most of his life in prison.

His decades behind bars kept him from learning about life on the outside, including matters of mental health. Diagnosed with schizophrenia and suffering from bouts of paranoia, Ka didnt understand what was going wrong with him.

I had a mental illness and I didnt know it, he said. Its like youve got something wrong with you, but you dont know what it is. They say, This is your diagnosis, but you dont know what it is. Youre paranoid. Okay, what does that mean? Youre schizophrenic. Okay, whats that?

As he was approaching his release date three years ago, Ka connected with the counselors of Greater Trenton Behavioral Health Care, an agency that coaches people with histories of serious mental illness to live more independently.

The agencys supportive housing program helps clients to make doctors appointments, attend therapy sessions and track medications. Started in 2006 with just 12 clients, the program is now helping Ka and more than 200 others to gain what might be the greatest of medical benefits a home.

Greater Trenton is working with the two-year-old Trenton Health Team, a collaboration among the city, local hospitals, clinics and social service organizations that is trying to stem the high rates of emergency room visits in the city. What the team and its cohorts are repeatedly finding is that the sickest, most expensive patients are often also homeless.

Closely integrating housing and medical care is a growing trend, said Ruth Perry, executive director of the health team. The Trenton Health Team is working very hard to understand the health needs of our homeless residents, and looks forward to collaborating with our community partners to end the scourge of homelessness so that the homeless residents of Trenton can have better health and a better quality of life.

Greater Trentons supportive housing program helps former inmates, rehabilitated patients from state hospitals and other individuals with serious mental illnesses who are at risk of homelessness.

A NORMAL LIFE

I had been in prison for 35 years of my life, Ka said. This is the longest I have ever been out of prison, since I was like 10 years old.

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Trenton health care program gives a home to former inmates and patients with mental illnesses

John Roberts Health Care Switch Sparks 'Deep' Supreme Court 'Discord': CBS News (VIDEO)

Nancy Pelosi Speaker John Boehner Jerrold Nadler

"Today, in upholding the Affordable Care Act, the Supreme Court has shown that, even at a time when Washington seems to have reached a new level of dysfunction, there remains a respect for the rule of law, for precedent, and for the ability of Congress to legislate on matters that affect the American people," Rep. Jerrold Nadler (D-N.Y.) said in a statement. "By not caving in to the most craven political calls, it appears the Court has stood by more than 70 years of legal precedent to ensure that: some 32 million Americans will have access to health insurance; we stop the unnecessary deaths of 42,000 Americans annually who die simply because they lack health insurance; insurers can no longer deny a child health care because of pre-existing conditions; millions of young adults receive coverage on their parents' plans until age 26; insurers can no longer impose lifetime limits on coverage; millions of Americans receive free preventive care; and, seniors save billions of dollars on prescription drugs. "The Affordable Care Act will now assume its rightful place, along with Social Security and Medicare, as powerful testimony to what our nation can achieve to benefit the lives of all Americans. Today's decision will, I truly hope, put to rest the partisan attacks from the Right against the law and many of its provisions. Republicans have threatened to continue their attempts to repeal these provisions, but let us all hope that they will respect the Court's ruling and put the health and wellbeing of the American people ahead of insurance companies."

"Today's decision makes one thing clear: Congress must act to repeal this misguided law," said Sen. Republican Leader Mitch McConnell. "Obamacare has not only limited choices and increased health care costs for American families, it has made it harder for American businesses to hire. Today's decision does nothing to diminish the fact that Obamacare's mandates, tax hikes, and Medicare cuts should be repealed and replaced with common sense reforms that lower costs and that the American people actually want. It is my hope that with new leadership in the White House and Senate, we can enact these step-by-step solutions and prevent further damage from this terrible law."

Republican Governors Association Chairman Bob McDonnell issued the following statement regarding the Supreme Court's decision to uphold the Patient Protection and Affordable Care Act: "Today's ruling crystallizes all that's at stake in November's election. The only way to stop Barack Obama's budget-busting health care takeover is by electing a new president. Barack Obama's health care takeover encapsulates his Presidency: Obamacare increases taxes, grows the size of government and puts bureaucrats over patients while doing nothing to improve the economy. It's never been more important that we elect a President who understands the marketplace and will make job creation his top priority. By replacing Barack Obama with Mitt Romney, we will not only stop the federal government's healthcare takeover, but will also take a giant step towards a full economic recovery."

"Dr. Coburn will be reviewing the ruling and will respond with an updated plan to repeal and replace this unworkable law. The Court affirmed Congress' power to tax people if they don't eat their broccoli. Now it's up to the American people to decide whether they will tolerate this obscene abuse of individual liberty," said John Hart, a spokesman for Sen. Coburn.

"Today's Supreme Court decision sets the stakes for the November election. Now, the only way to save the country from ObamaCare's budget-busting government takeover of health care is to elect a new president," said RNC Chairman Reince Priebus. "Under President Obama's signature legislation, health care costs continue to skyrocket, and up to 20 million Americans could lose their employer-based coverage. A panel of unelected bureaucrats now has the unprecedented authority to come between elderly patients and their doctors. Meanwhile, the rules and regulations placed on job creators and small businesses make it nearly impossible to hire new workers at a time when Americans desperately need jobs. "We need market-based solutions that give patients more choice, not less. The answer to rising health care costs is not, and will never be, Big Government. "We must elect a president who understands the economy, respects free enterprise, and can provide the leadership we now so desperately need. On Election Day, we must elect Mitt Romney and put America on the path toward a brighter economic future and successful health care reform."

Today, House Majority Leader Eric Cantor (R-VA) released the following statement on the Supreme Court ruling on the President's health care law: "The Supreme Court's decision to uphold ObamaCare is a crushing blow to patients throughout the country. ObamaCare has failed to keep the President's basic promise of allowing those who like their health care to keep it, while increasing costs and reducing access to quality care for patients. In this tough economy, jobs and economic growth are on the minds of most Americans, but ObamaCare has increased uncertainty for small businessmen and women and forced them to put their hiring decisions on hold. "During the week of July 9th, the House will once again repeal ObamaCare, clearing the way for patient-centered reforms that lower costs and increase choice. We support an approach that offers simpler, more affordable and more accessible health care that allows people to keep the health care that they like. "The Court's decision brings into focus the choice the American people have about the direction of our country. The President and his party believe in massive government intrusions that increase costs and take decisions away from patients. In contrast, Republicans believe in patient-centered, affordable care where health care decisions are made by patients, their families and their doctors, not by the federal government."

House Democratic Whip Steny H. Hoyer (MD) released the following statement today after the Supreme Court's decision on the Affordable Care Act: "Our highest court has weighed in, and its decision to uphold the Patient Protection and Affordable Care Act is a victory for all Americans who have ever worried about being able to access or afford the care they need. Democrats are proud to have worked hard to pass this landmark legislation in 2010 and of our efforts to make sure it is implemented in a way that continues to yield new benefits for patients, employers, and care providers. "The Affordable Care Act made it illegal for insurance companies to discriminate against patients on the basis of pre-existing conditions, allowed young people to remain on their parents' plans until age 26, and prohibited insurance companies from charging women higher premiums than men. The Medicare Part D 'donut hole' is closing, and seniors on Medicare now have access to free preventive services like mammograms and colonoscopies. Moreover, the Affordable Care Act provides deficit savings of more than $1 trillion over the next two decades. The Affordable Care Act further brought peace of mind to the 30 million uninsured Americans who will finally be able to access affordable coverage once the law is fully implemented. "Republicans have been trying to repeal the Affordable Care Act since the day it was enacted, and they have been eagerly awaiting today's ruling. But they must now accept that the Affordable Care Act will remain in place and that the time for litigation and partisan posturing on this issue ought to come to an end. Republicans now have a responsibility to work with Democrats to implement the Affordable Care Act, and I call on them to do so in order to make care affordable and accessible to Americans."

Following the Supreme Court's decision affirming the constitutionality of the Affordable Care Act, former Governor and U.S. Senate candidate Tim Kaine today released the following statement: "The Affordable Care Act is an important first step in curbing discriminatory insurance company practices and increasing access to health care, but more needs to be done to bring down costs. Our government, businesses, and citizens cannot continue to spend more than any other nation on health care while getting second-rate results. As Senator, I am committed to working with all stakeholders to find additional improvements to the Affordable Care Act that give all Americans affordable access to high quality services. "While there is more work to do, it is worth noting what has already been accomplished under the Affordable Care Act. Nearly 63,000 more young people in Virginia have health coverage, more than 800,000 Virginia seniors have received free preventive care, millions of small businesses are now eligible for tax credits, and twenty million American women have access to cancer screenings and contraception without co-pays. And we've put an end to the egregious abuses by insurance companies that denied coverage to children with preexisting conditions, charged women higher premiums for the same coverage, and dropped folks when they got sick. "My opponent regularly calls for a full repeal of this law, despite the positive results it's already delivering for Virginia. In the decade encompassing George Allen's six years as a U.S. Senator, the average insurance premium for families more than doubled and over 12 million more Americans were uninsured. Clearly, inaction was not a solution, and neither are continued calls for repeal. Instead we must work together to strengthen this existing program and improve cost controls."

"In passing health reform, we made history for our nation and progress for the American people. We completed the unfinished business of our society and strengthened the character of our country. We ensured health care would be a right for all, not a privilege for the few. Today, the Supreme Court affirmed our progress and protected that right, securing a future of health and economic security for the middle class and for every American."

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John Roberts Health Care Switch Sparks 'Deep' Supreme Court 'Discord': CBS News (VIDEO)

On health care: The tax man cometh

July 8, 2012

By STEPHEN OHLEMACHER, Associated Press

WASHINGTON (AP) -- The Supreme Court's decision to uphold most of President Barack Obama's health care law will come home to roost for most taxpayers in about two-and-a-half years, when they'll have to start providing proof on their tax returns that they have health insurance.

That scenario puts the Internal Revenue Service at the center of the debate, renewing questions about whether the agency is capable of policing the health care decisions of millions of people in the United States while also collecting the taxes needed to run the federal government.

Under the law, the IRS will provide tax breaks and incentives to help pay for health insurance and impose penalties on some people who don't buy coverage and on some businesses that don't offer it to employees.

The changes will require new regulations, forms and publications, new computer programs and a big new outreach program to explain it all to taxpayers and tax professionals. Businesses that don't claim an exemption will have to prove they offer health insurance to employees.

The health care law "includes the largest set of tax law changes in more than 20 years," according to the Treasury inspector general who oversees the IRS. The agency will have to hire thousands of workers to manage it, requiring significant budget increases that already are being targeted by congressional Republicans determined to dismantle the president's signature initiative.

"Knowing the complexity of the health law, there's no question that the IRS is going to struggle with this," said Rep. Charles Boustany Jr., R-La., chairman of the House Ways and Means oversight subcommittee. "The IRS wants more resources. Well, we need to start digging down into what are they doing with the resources and personnel."

Treasury spokeswoman Sabrina Siddiqui said, "The overwhelming majority of funds used by the agency to implement the Affordable Care Act go to administer the premium tax credits, which will be a tax cut averaging about $4,000 for more than 20 million middle-class people and families."

The Supreme Court, in its 5-4 ruling, upheld the mandate that most Americans get health insurance. The majority said Congress has the power to enforce the mandate under its taxing authority. The decision labeled the penalties a tax, noting that they will be collected by the IRS.

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On health care: The tax man cometh

Freedom Steel’s June Tablet Giveaway a Huge Success

During the month of June 2012, Freedom Steel gave away 21 tablets to its Steel Building customers. Everyday, the first building sold meant a brand new tablet. Spreading the word through newsletters and social media outlets, customers began competing to be the first call of the day to ensure they would receive a tablet.Delray Beach, Florida (PRWEB) July 08, 2012 During the month of June 2012 ...

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Freedom Steel’s June Tablet Giveaway a Huge Success

Man-animal conflict on the rise

The rapid changes taking place in the forest eco system, mainly owing to excessive human intervention and climate change, has been leading tofrequent straying of wild animals into human habitation in the forest areas of Konni and Ranni in recent times.

The sad fate of a male leopard that had strayed into the small hamlet of Iyravon nestling on the borders of the Kummannoor forests in Konni Forest division on Sunday was the latest in the series of man-animal conflicts taking place in this part of the State during the past six months.

The leopard that strayed into the bordering village had sent panic waves among the hapless villagers. The spontaneous reaction of the panicky people to ensure their protection from the wild beast had resulted in the death of the leopard, later. Meanwhile, the violent animal had also attacked a few people in a stressful mood.

This is the second leopard that had met with a similar fate along the forest fringes in the district during the past five months. A ferocious female leopard that had strayed into the village of Angamoozhy in the adjoining Ranni Forest division was killed by an unruly mob, earlier, in February.

According to villagers, instances of leopards, king cobras, wild elephants, etc, straying into the villages along the forest fringes have become more frequent in recent times. They attribute this to the growing menace of poaching, illicit brewing in the forest areas of Konni, especially Kummannoor and surrounding areas.

Excessive human intervention in the forests have led to depletion of green cover in many areas.

The mushrooming of granite quarries along the forest borders has also been leading to drastic changes in the forest eco system, forcing the wild fauna to stray out from their natural habitats, say experts. Unscrupulous quarrying of rocks has reportedly resulted in drastic depletion of the ground water table in the region and this amply justifies the straying out of wild animals from the forests, they added.

The Rapid Response Team constituted by the Ranni Divisional Forest Officer, R.Kamalahar, has already rescued as many as 133 wild animals belonging to 18 species from the villages adjoining the forests during

the past eight months.

However, sources attached to Forest department confided that the department was yet to be made properly equipped to face the challenges posed by ferocious wild animals straying out into human habitation.

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Man-animal conflict on the rise

Swimming Prohibited Sunday at Two Area Beaches

Two beaches in Monroe County are closed on what is the last day of a long holiday weekend for many people.

Despite warm temperatures, the county closed the beach for swimming at Ontario Beach Park. The water testing done this morning showed high bacteria levels at the beach in Charlotte.

Swimming is prohibited as a precaution at Hamlin Beach State Park today as well. The state said the beach is closed as a precautionary step due to results from water quality tests.

Additional samples will be taken Sunday and Monday to try and determine when the beach at Hamlin can reopen for swimming.

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Swimming Prohibited Sunday at Two Area Beaches

Top 10 beaches in Hong Kong

Hong Kong isn't all banks and skyscrapers. There are plenty of great beaches to swim, sunbathe, surf and windsurf on, says Vaudine England – and don't be put off by the shark nets • As featured in our Hong Kong city guide Cheung Sha Beaches, Lantau Most visitors to Lantau Island aim for the orderly sands of Silvermine Bay, the closest beach to the ferry port at Mui Wo, but better swimming can be ...

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Top 10 beaches in Hong Kong

A First for MUN

It's entitled "The Ligher Side of Black Holes." For the first time in the university's history, Memorial will host the Canadian Conference on General Relativity and Astro Physics. The Biennial event will feature more than three dozen delegates from across the country, discussing such 'light' topics as gravity and string theory. The conference runs from July 9 to 12 at MUN's St. John's campus. A public lecture on black holes will take place Tuesday at the university's Bruneau Center.

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A First for MUN

New University Team To Build On Southamptons Reputation For Aerospace

Sun, Jul 08, 2012

The University of Southampton will launch its new aerospace sector team at the 2012 Farnborough International Air Show on Tuesday. Aerospace Southampton will expand the Universitys involvement in the sector and broaden research collaborations with key players, such as BAE Systems, EADS and the Ministry of Defence.

Southampton has established a world-leading reputation for research and education in all areas of the aerospace industry ranging from aerodynamics and aero acoustics to aircraft noise and vibration as well as computational engineering and agent-based systems. The University is also pushing the boundaries and applying its expertise in new areas, such as unmanned aerial vehicles (UAVs) and space debris.

A number of world-renowned research groups and facilities which support aerospace-related projects are based at the University of Southampton including the RJ Mitchell Wind Tunnel, the Institute of Sound and Vibration Research, the Airbus Aircraft Noise Technology Centre and the Rolls-Royce University Technology Centres at Southampton.

The aerospace industry faces a number of major engineering and environmental challenges in the years ahead and the University of Southampton is perfectly positioned to continue its world-changing impact on the sector, said Don Spalinger, the Universitys Director of Research and Innovation Services . The creation of Aerospace Southampton will build on our global reputation and excellent links with industry will help us to maximise future opportunities for our research.

Aerospace Southampton also has the potential to equip our graduates for leadership in the sector and it will consult with alumni and external stakeholders to identify how to enhance the Universitys contribution to the industry, Spalinger continued.

Professor Mark Spearing, Southamptons Pro-Chancellor (International), will Chair Aerospace Southampton which encompasses staff, students and representatives from major research groups across the University. Industry executives from leading commercial and industry organisations will support Aerospace Southampton through a new advisory board.

(Image provided by University of Southampton)

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New University Team To Build On Southamptons Reputation For Aerospace

The All or Nothing Progress of Longevity Science

Competition drives progress, but put enough humans into any field and the successful groups will start to form cartels in order to keep their leading position without having to compete as hard for it. It is inherent in the human condition that we self-sabotage very well and very aggressively just as soon as we achieve enough success to feel somewhat elevated over our less fortunate peers. Who can even begin to guess how many opportunities have been wasted, how much potential technological progress has been lost thanks to these urges?

The world of technology is now remarkably flat. The majority of the amenities of modern technology are available to the majority of the world: the descendants of peasants can fly for the same cost as the bloodlines of kings, cars and mobile phones are ubiquitous, and holding vast wealth doesn't in fact give a person any great and massive advantage over the middle class - or even the poor in wealthier regions - when it comes to the variety of available medical technology. Every new advance moves rapidly from being comparatively expensive, faulty, and scarce to being comparatively cheap, reliable, and widespread - whether we are talking about air conditioning or heart surgery, though the pernicious effects of regulation slow down the applications of biotechnology to a crawl in comparison to other lines of technological progress.

One of the defining features of our age is the degree to which the very wealthy and the very connected use the same technologies as the rest of us. When new technology is developed we all win - it doesn't matter which research or development group got there first, because we will all have access soon enough. What does matter is how soon that new technology arrives, and that is a function of the size and level of competition in the research and development communities. Michael Batin has this to say, machine translated from the Russian:

In most types of social interactions, people want to be the first. In sport, business, politics, the most coveted, the most honorable place - this place is number 1. This behavior is due to our neurophysiology, our genetics. Often, the winner takes all. During the war, or fight a duel to win - means to survive.

But, in the fight against aging is a totally different situation. We will survive, if any other scientist, institution or fund wins [in the fight against] aging. Yes, these [strangers get] the glory, money and women. At the same time everyone else interested in the victory over the aging gets a chance to live. No amount of money can [be] compared with the value of life. When you're alive, you have the opportunity to achieve whatever you want. When a person is dead, for him [nothing] is possible.

When we see someone [doing better than us to] extend the life of an animal model [and struggle] with aging, [he benefits us] because he can give us life. The more people who are trying to find a cure for old age, the greater our chances of survival, [and] for the return of youth to radical life extension.

The larger the community, the more healthy competition, the better the outcome and the faster the progress towards the end goal. When it comes to the biotechnology of rejuvenation we will either all win together or we all lose together - there is little in the way of middle ground in technological progress. That result is entirely determined by how fast we can create this sort of future medicine, such as that outlined in the SENS proposals.

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Considering Mitochondrial Dynamics in the Context of Aging

A herd of mitochondria exists in every cell, producing the ATP necessary to power that cell. Damage to mitochondria is important in aging, but how damage progresses in a cell's mitochondrial population is complicated by the fact that these are not completely discrete and static entities. They multiply like bacteria (fission), can merge with one another (fusion), and can also exchange individual components of their molecular machinery - so damage can be both passed around or mitigated depending on circumstances. Here researchers build models to better understand this dynamic: "Mitochondria are organelles that play a central role as 'cellular power plants'. The cellular organization of these organelles involves a dynamic spatial network where mitochondria constantly undergo fusion and fission associated with the mixing of their molecular content. ... Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial function and quality control during aging ... We demonstrate that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present. Prompted by earlier observations that mitochondrial fission itself can cause a partial drop in mitochondrial membrane potential, we tested the consequences of mitochondrial dynamics being harmful on its own. Next to directly impairing mitochondrial function, pre-existing molecular damage may be propagated and enhanced across the mitochondrial population by content mixing. In this situation, such an infection-like phenomenon impairs mitochondrial quality control progressively. However, when imposing an age-dependent deceleration of cycles of fusion and fission, we observe a delay in the loss of average quality of mitochondria. This provides a rational why fusion and fission rates are reduced during aging and why loss of a mitochondrial fission factor can extend life span in fungi. We propose the 'mitochondrial infectious damage adaptation' (MIDA) model according to which a deceleration of fusion-fission cycles reflects a systemic adaptation increasing life span."

Link: http://dx.doi.org/10.1371/journal.pcbi.1002576

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Stem Cell Transplant Explored as Alzheimer's Disease Therapy

Work on stem cell transplants in rats is outlined here: "Alzheimer's disease (AD) has been called the disease of the century with significant clinical and socioeconomic impacts. Epidemiological studies point out that AD affects 5% of the population over 65, and, parallel with increasing lifespan, the incidence of disease will rise dramatically. Clinically AD is characterized by a progressive learning capacity impairment and memory loss, especially memories of recent events ... Adult neural tissues have limited sources of stem cells, which makes neurogenesis in the brain less likely. Stem cells transplantation seems to be a promising strategy for treatment of several central nervous system (CNS) degenerative diseases such as AD, amyotrophic lateral sclerosis (ALS), and Parkinson's disease ... The present study aims to evaluate the effect of bone marrow mesenchymal stem cells (MSCs) grafts on cognition deficit in chemically and age-induced Alzheimer's models of rats. ... Two months after the treatments, cognitive recovery was assessed ... Results showed that MSCs treatment significantly increased learning ability and memory in both age- and [chemical]-induced memory impairment. Adult bone marrow mesenchymal stem cells show promise in treating cognitive decline associated with aging and [nucleus basalis magnocellularis] lesions."

Link: http://dx.doi.org/10.1155/2012/369417

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Stem Cell Transplant Explored as Alzheimer’s Disease Therapy

Work on stem cell transplants in rats is outlined here: "Alzheimer's disease (AD) has been called the disease of the century with significant clinical and socioeconomic impacts. Epidemiological studies point out that AD affects 5% of the population over 65, and, parallel with increasing lifespan, the incidence of disease will rise dramatically. Clinically AD is characterized by a progressive learning capacity impairment and memory loss, especially memories of recent events ... Adult neural tissues have limited sources of stem cells, which makes neurogenesis in the brain less likely. Stem cells transplantation seems to be a promising strategy for treatment of several central nervous system (CNS) degenerative diseases such as AD, amyotrophic lateral sclerosis (ALS), and Parkinson's disease ... The present study aims to evaluate the effect of bone marrow mesenchymal stem cells (MSCs) grafts on cognition deficit in chemically and age-induced Alzheimer's models of rats. ... Two months after the treatments, cognitive recovery was assessed ... Results showed that MSCs treatment significantly increased learning ability and memory in both age- and [chemical]-induced memory impairment. Adult bone marrow mesenchymal stem cells show promise in treating cognitive decline associated with aging and [nucleus basalis magnocellularis] lesions."

Link: http://dx.doi.org/10.1155/2012/369417

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

A Lack of Biotechnology is the Only Limit on Human Longevity

Are there limits on human longevity? Sure. Few people will make it past a hundred years of age in the environment of today's medical technology - but today is today, and the technology of tomorrow will be a different story. If you want to talk about longevity and mortality rates, you have to qualify your position by stating what sort of applied biotechnologies are available. Longevity is a function of the quality and type of medicine that is available across a life span.

It so happens that most of the advances in medicine achieved over the course of human history, the vast majority of which have occurred in the past fifty years, have solved problems that killed people early in life. Infectious disease, for example, is controlled to a degree that would have been thought utopian in the squalor of Victorian England. The things that kill older people are a harder set of challenges: great progress has been made in reducing mortality from heart disease in the past few decades, for example, but that is just one late stage consequence of the complex array of biochemical processes that we call aging.

The point of this discussion? It is that tremendous progress in medicine, including the defeat or taming of many varied causes of death and disability, has not greatly lengthened the maximum human life span as experienced in practice. The research community hasn't really started in earnest on the work on rejuvenation biotechnology that will achieve that end - the story of medicine to date has been work on other line items, or largely futile attempts to patch over the failure modes that lie at the end of aging.

There are things that need to be fixed that currently limit human life span. Since aging is only an accumulation of damage, there is in fact a gentle trend towards extended life as a result of general improvements across the board in medicine - perhaps one year of additional life with every five years of technological progress at the present time. On average, people with access to the modern environment of technology and support are suffering biological damage at the level of cells and molecular machinery more slowly across their lives. But this incidental life extension is slow going indeed.

Given this history of medical progress you will find many life science researchers and advocates who view the human life span as bounded - they look to past progress and extrapolate to assume that future progress can only carry on improving things within the existing human maximum life span. In other words that more and more people will live in good health closer to that maximum, but that the maximum is set in stone. There's even a name for this goal, "compression of morbidity".

This is a ridiculous view when considered in the light of reliability theory and aging, but it is widely held and therefore something that advocates for rejuvenation biotechnology must work to dismiss. The future of medicine in the next few decades is not about gaining a decade of life with no hope of pushing out human life span beyond 120 years - it is about building the alpha versions of medical technologies that can provide indefinite healthy life spans through periodic repair of the known forms of cellular and molecular damage that cause aging. But unless many more people come to understand this point, there will continue to be the same lack of support for research that will lead to radical change in the relationship of medicine and aging. Advocate and gerontologist Aubrey de Grey touches on these issues in a recent editorial:

Is there a biological limit to longevity?

Gerontologists and demographers have argued about this for a long time, with the balance of opinion heavily influenced by the changes seen in the wealthiest nations' "survival curves" - graphs showing, broadly speaking, the proportion of an initial population that survived to a given age. Until a couple of centuries ago, these curves looked very much like radioactive decay curves, because one's chance of dying at any given age was pretty much the same. As medicine emerged and we became protected from most infectious diseases, the curve became more rectangular, implying a biological limit that most people were getting fairly close to.

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So, why am I exercised about this? Simply because the belief in a biological limit to longevity is very often elided into a belief in a medical limit. And unfortunately, this inference is being taken seriously by influential observers and commentators, with all that that entails for public policy going forward.

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Technology is about transcending what nature has created. To say that the biological limits to longevity are any kind of evidence of what we can do with medicine is a mixing of apples with oranges of the most egregious nature. And the reason it matters, of course, is that those who have not the time or intellect to see through it have the power to dissipate society's enthusiasm for attacking aging, by reinforcing the age-old belief that it is as immutable as the heat death of the universe. The result is a delay in the defeat of aging with medicine, the unnecessary loss of life and the unnecessary perpetuation of the untold suffering caused by aging. This cannot be allowed.

We must clarify, loud and clear, that medicine is about transcending biology.

Just so.

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Nitric Oxide and Aging Blood Vessels

Nitric oxide levels are a possible target for therapies aimed at some of the signs of aging in blood vessels: "Many disorders emerge with advancing aging, and cardiovascular diseases (CVD) are a major cause of morbidity and mortality in the elderly. The term vascular aging encompasses all the structural and functional alterations in the blood vessels with progressive aging. Both smooth muscle cells and intima layers are affected. These vascular changes lead to endothelial dysfunction, arterial stiffness in consequence of intense remodeling and calcification, impaired angiogenesis, greater susceptibility to vascular injury and atherosclerotic lesions. The mechanisms underlying vascular aging are complex and involve multiple pathways and factors ... In this complex scenario, vascular function depends on the balanced production/bioavailability of nitric oxide (NO), which is maintained by the normal activity of endothelial nitric oxide synthase (eNOS). On the other hand, excessive amount of NO produced by inducible nitric oxide synthase (iNOS) up-regulation contributes to vascular dysfunction. Evidence obtained from experimental models indicates that decreased NO bioavailability as well as increased reactive nitrogen species (RNS) production contributes to aging-associated vascular dysfunction. ... Pharmacological modulation of NO generation and expression/activity of NOS isoforms may represent a therapeutic alternative to prevent the progression of cardiovascular diseases."

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382417/

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm